ketanserin


SMILES Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2
InChIKey FPCCSQOGAWCVBH-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight (Da) 395.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Ligand site mutations α1B 5-HT1D 5-HT2A 5-HT2C

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 Guide to Pharmacology
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 7.4 7.45 7.5 Guide to Pharmacology
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.1 8.9 9.7 Guide to Pharmacology
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKd 8.6 9.15 9.7 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.1 6.4 6.7 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.8 7.15 7.5 Guide to Pharmacology
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 4.7 4.7 4.7 Guide to Pharmacology
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 5.9 6.2 6.5 Guide to Pharmacology
α1A ADA1A Human Adrenoceptors A pKi 8.2 8.2 8.2 Guide to Pharmacology
α1B ADA1B Human Adrenoceptors A pKi 8.2 8.2 8.2 Guide to Pharmacology
α1D ADA1D Human Adrenoceptors A pKi 7.8 7.8 7.8 Guide to Pharmacology
D1 DRD1 Human Dopamine A pKi 6.7 6.7 6.7 Guide to Pharmacology
D5 DRD5 Human Dopamine A pKi 5.6 5.6 5.6 Guide to Pharmacology
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 8.6 8.8 9.0 Guide to Pharmacology
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKd 8.8 8.8 8.8 Guide to Pharmacology
5-HT7 5HT7R Mouse 5-Hydroxytryptamine A pKi 6.4 6.4 6.4 Guide to Pharmacology
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 6.6 6.65 6.7 Guide to Pharmacology
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKi 5.4 5.4 5.4 Guide to Pharmacology
5-HT2A 5HT2A Pig 5-Hydroxytryptamine A pKd 8.88 8.88 8.88 ChEMBL
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 7.3 7.3 7.3 ChEMBL
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 4.7 4.7 4.7 ChEMBL
H1 HRH1 Guinea pig Histamine A pKi 8.0 8.0 8.0 ChEMBL
H1 HRH1 Guinea pig Histamine A pKd 8.85 8.85 8.85 ChEMBL
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.72 5.72 5.72 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKi 8.0 8.0 8.0 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 5.88 5.89 5.9 ChEMBL
H1 HRH1 Human Histamine A pKi 8.7 8.7 8.7 ChEMBL
D2 DRD2 Rat Dopamine A pKi 6.31 6.47 6.66 ChEMBL
D4 DRD4 Human Dopamine A pKi 8.46 8.46 8.46 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.71 5.72 5.74 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.55 5.55 5.55 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.75 6.75 6.75 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.0 7.18 7.36 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKd 8.57 8.62 8.66 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.97 9.12 9.64 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKd 6.1 6.1 6.1 ChEMBL
5-HT2C K7GSR7 Pig 5-Hydroxytryptamine A pKi 5.5 6.92 7.31 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 6.62 6.62 6.62 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.0 5.65 6.95 PDSP Ki database
5-HT1D 5HT1D Rat 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1D F1MMU1 Bovine 5-Hydroxytryptamine A pKi 5.0 5.7 6.0 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.0 5.36 5.72 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.0 5.43 5.98 PDSP Ki database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.0 5.33 5.71 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.01 8.7 9.41 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 8.3 8.93 9.52 PDSP Ki database
5-HT2A 5HT2A Bovine 5-Hydroxytryptamine A pKi 8.66 8.66 8.66 PDSP Ki database
5-HT2A 5HT2A Pig 5-Hydroxytryptamine A pKi 8.37 8.37 8.37 PDSP Ki database
5-HT2B F6QI78 Bovine 5-Hydroxytryptamine A pKi 8.62 8.62 8.62 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 6.99 7.32 7.68 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 5.12 6.27 6.7 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.55 5.55 5.55 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.49 6.3 6.66 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.7 7.06 7.77 PDSP Ki database
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKi 5.4 5.46 5.5 PDSP Ki database
5-HT4 5HT4R Rat 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 6.43 6.43 6.43 PDSP Ki database
α2B ADA2B Human Adrenoceptors A pKi 6.7 6.7 6.7 PDSP Ki database
α2B ADA2B Rat Adrenoceptors A pKi 6.65 6.65 6.65 PDSP Ki database
5-HT7 5HT7R Guinea pig 5-Hydroxytryptamine A pKi 5.54 5.87 6.2 PDSP Ki database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 5.12 5.74 6.1 PDSP Ki database
5-HT6 5HT6R Mouse 5-Hydroxytryptamine A pKi 6.0 6.2 6.4 PDSP Ki database
5-HT5A 5HT5A Mouse 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 5.0 6.95 8.9 PDSP Ki database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 5.36 5.48 5.6 PDSP Ki database
D1 DRD1 Rat Dopamine A pKi 6.0 6.35 6.7 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 5.74 6.27 6.52 PDSP Ki database
D1 DRD1 Bovine Dopamine A pKi 6.4 6.4 6.4 PDSP Ki database
5-HT2B 5HT2B Mouse 5-Hydroxytryptamine A pKi 6.69 6.69 6.69 PDSP Ki database
D5 DRD5 Human Dopamine A pKi 5.6 5.6 5.6 PDSP Ki database
D1 DRD1 Human Dopamine A pKi 6.33 6.53 6.72 PDSP Ki database
5-HT1B 5HT1B Guinea pig 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
D2 DRD2 Dog Dopamine A pKi 6.72 6.72 6.72 PDSP Ki database
H1 HRH1 Human Histamine A pKi 8.75 8.75 8.75 PDSP Ki database
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 4.7 4.7 4.7 PDSP Ki database
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 8.05 8.05 8.05 Drug Central
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.3 8.3 8.3 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.01 8.01 8.01 Drug Central
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.17 8.17 8.17 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.12 8.12 8.12 Drug Central
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 8.33 8.33 8.33 Drug Central
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.26 8.26 8.26 Drug Central
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.19 8.19 8.19 Drug Central
α1A ADA1A Human Adrenoceptors A pKi 8.09 8.09 8.09 Drug Central
α1B ADA1B Human Adrenoceptors A pKi 8.09 8.09 8.09 Drug Central
α1D ADA1D Human Adrenoceptors A pKi 8.11 8.11 8.11 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.17 8.17 8.17 Drug Central
D1 DRD1 Human Dopamine A pKi 8.17 8.17 8.17 Drug Central
D4 DRD4 Human Dopamine A pKi 8.07 8.07 8.07 Drug Central
D5 DRD5 Human Dopamine A pKi 8.25 8.25 8.25 Drug Central
H1 HRH1 Human Histamine A pKi 8.06 8.06 8.06 Drug Central
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 8.14 8.14 8.14 Drug Central
5-HT7 5HT7R Mouse 5-Hydroxytryptamine A pKi 8.19 8.19 8.19 Drug Central
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 8.24 8.24 8.24 Drug Central
5-HT1B 5HT1B Mouse 5-Hydroxytryptamine A pKi 8.08 8.08 8.08 Drug Central
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 8.17 8.17 8.17 Drug Central
D2 DRD2 Rat Dopamine A pKi 8.19 8.19 8.19 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 6.8 6.8 6.8 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 8.18 8.18 8.18 Drug Central
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 8.03 8.03 8.03 Drug Central
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 8.24 8.24 8.24 Drug Central
5-HT1B 5HT1B Mouse 5-Hydroxytryptamine A pKi 8.3 8.3 8.3 Guide to Pharmacology
5-HT2C 5HT2C Mouse 5-Hydroxytryptamine A pKi 7.55 7.55 7.55 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pIC50 5.2 5.3 5.4 Guide to Pharmacology
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.8 4.8 4.8 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 5.75 5.75 5.75 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 6.54 6.54 6.54 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 8.57 8.57 8.57 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 7.08 8.33 9.46 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pEC50 8.98 8.98 8.98 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pIC50 8.28 8.28 8.28 Drug Central
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pIC50 8.18 8.18 8.18 Drug Central
A3 AA3R Human Adenosine A pIC50 8.07 8.07 8.07 Drug Central
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pIC50 5.19 5.19 5.19 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pIC50 6.57 6.58 6.58 ChEMBL
NPS NPSR1 Human Neuropeptide S A Potency 5.8 5.8 5.8 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 4.5 4.5 4.5 ChEMBL