levorphanol


SMILES Oc1ccc2c(c1)[C@]13CCCC[C@H]3[C@@H](C2)N(CC1)C
InChIKey JAQUASYNZVUNQP-USXIJHARSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 0
Molecular weight (Da) 257.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
κ OPRK Mouse Opioid A pKi 8.0 8.0 8.0 ChEMBL
κ OPRK Guinea pig Opioid A pKi 8.64 8.64 8.64 ChEMBL
δ OPRD Human Opioid A pKi 8.38 8.38 8.38 ChEMBL
κ OPRK Human Opioid A pKi 8.64 8.64 8.64 ChEMBL
μ OPRM Human Opioid A pKi 9.68 9.68 9.68 ChEMBL
δ OPRD Human Opioid A pKi 8.08 8.08 8.08 Drug Central
κ OPRK Human Opioid A pKi 8.06 8.06 8.06 Drug Central
μ OPRM Human Opioid A pKi 8.01 8.01 8.01 Drug Central
κ OPRK Mouse Opioid A pKi 8.1 8.1 8.1 Drug Central
μ OPRM Mouse Opioid A pKi 8.02 8.02 8.02 Drug Central
κ OPRK Guinea pig Opioid A pKi 8.06 8.06 8.06 Drug Central
μ OPRM Mouse Opioid A pKi 9.52 9.52 9.52 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Human Opioid A pIC50 9.89 9.89 9.89 Guide to Pharmacology
δ OPRD Human Opioid A pIC50 8.29 8.41 8.54 ChEMBL
κ OPRK Human Opioid A pIC50 8.4 8.4 8.4 ChEMBL
μ OPRM Human Opioid A pIC50 9.89 9.89 9.89 ChEMBL
μ OPRM Mouse Opioid A pIC50 6.56 6.56 6.56 ChEMBL