lofexidine


SMILES CC(C1=NCCN1)Oc1c(Cl)cccc1Cl
InChIKey KSMAGQUYOIHWFS-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 3
Molecular weight (Da) 258.0

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2A ADA2A Human Adrenoceptors A pKi 8.36 8.36 8.36 Guide to Pharmacology
α2B ADA2B Human Adrenoceptors A pKi 7.17 7.17 7.17 Guide to Pharmacology
α2C ADA2C Human Adrenoceptors A pKi 7.16 7.16 7.16 Guide to Pharmacology
α2B ADA2B Human Adrenoceptors A pKi 7.17 7.17 7.17 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 7.16 7.16 7.16 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 8.36 8.36 8.36 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.9 6.9 6.9 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.16 8.16 8.16 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.08 8.08 8.08 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.15 8.15 8.15 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.14 8.14 8.14 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2B ADA2B Human Adrenoceptors A pEC50 6.9 6.9 6.9 ChEMBL
α2C ADA2C Human Adrenoceptors A pEC50 8.86 8.86 8.86 ChEMBL
α2A ADA2A Human Adrenoceptors A pEC50 8.2 8.2 8.2 ChEMBL