REMOXIPRIDE


SMILES CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC
InChIKey GUJRSXAPGDDABA-NSHDSACASA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Molecular weight (Da) 370.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D3 DRD3 Green monkey Dopamine A pKi 5.34 5.34 5.34 ChEMBL
D4 DRD4 Human Dopamine A pKi 5.41 5.41 5.41 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKd 5.4 5.4 5.4 ChEMBL
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 5.0 5.09 5.28 PDSP Ki database
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 5.3 5.3 5.3 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 5.3 5.3 5.3 PDSP Ki database
5-HT6 5HT6R Mouse 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 6.05 7.02 7.8 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 5.43 5.62 6.0 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 5.6 6.12 7.15 PDSP Ki database
D1 DRD1 Rat Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 5.69 6.07 7.27 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 5.07 5.17 5.26 PDSP Ki database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
H1 HRH1 Rat Histamine A pKi 5.0 5.2 5.59 PDSP Ki database
β2 ADRB2 Rat Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
D4 DRD4 Rat Dopamine A pKi 5.55 5.55 5.55 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.0 5.25 5.51 PDSP Ki database
5-HT1D F1MMU1 Bovine 5-Hydroxytryptamine A pKi 5.21 5.21 5.21 PDSP Ki database
D2 DRD2 Dog Dopamine A pKi 6.52 6.52 6.52 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.16 5.16 5.16 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.3 5.3 5.3 PDSP Ki database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 4.44 4.44 4.44 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKd 8.27 8.27 8.27 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.26 8.26 8.26 Drug Central
D3 DRD3 Human Dopamine A pKi 8.15 8.15 8.15 Drug Central
D4 DRD4 Human Dopamine A pKi 8.27 8.27 8.27 Drug Central
D2 DRD2 Green monkey Dopamine A pKi 8.22 8.22 8.22 Drug Central
D3 DRD3 Green monkey Dopamine A pKi 8.27 8.27 8.27 Drug Central
D2 DRD2 Green monkey Dopamine A pKi 6.06 6.06 6.06 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Rat Dopamine A pIC50 5.8 5.82 5.85 ChEMBL
D4 DRD4 Human Dopamine A pIC50 5.41 5.41 5.41 ChEMBL
D2 DRD2 Human Dopamine A pIC50 6.06 7.49 8.92 ChEMBL
D2 DRD2 Human Dopamine A pIC50 8.22 8.22 8.22 Drug Central
D2 DRD2 Rat Dopamine A pIC50 8.23 8.23 8.23 Drug Central