CHEMBL226636


SMILES COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C/c4ccc(F)cc4)CC3)C1CO2
InChIKey CVKQUGPVDVFRAT-ONEGZZNKSA-N

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 0
Rotatable bonds 7
Molecular weight (Da) 467.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2B ADA2B Human Adrenoceptors A pKi 6.79 7.41 7.85 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 7.14 7.71 8.35 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 6.93 7.42 8.05 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database