DROPERIDOL


SMILES O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1
InChIKey RMEDXOLNCUSCGS-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Molecular weight (Da) 379.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1B ADA1B Rat Adrenoceptors A pKi 8.01 8.01 8.01 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKi 9.18 9.18 9.18 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 7.39 7.39 7.39 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 7.0 7.0 7.0 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 5.78 5.78 5.78 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 6.59 6.59 6.59 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 6.27 6.27 6.27 ChEMBL
H1 HRH1 Human Histamine A pKi 6.28 6.28 6.28 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.86 6.86 6.86 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 5.95 5.95 5.95 ChEMBL
D1 DRD1 Human Dopamine A pKi 6.26 6.26 6.26 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.07 6.07 6.07 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.62 6.62 6.62 ChEMBL
D3 DRD3 Human Dopamine A pKi 9.03 9.03 9.03 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 9.13 9.13 9.13 ChEMBL
D2 DRD2 Human Dopamine A pKi 9.1 9.1 9.1 ChEMBL
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 8.34 8.48 8.62 PDSP Ki database
D2 DRD2 Bovine Dopamine A pKi 9.0 9.0 9.0 PDSP Ki database
D1 DRD1 Bovine Dopamine A pKi 6.06 6.06 6.06 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 9.6 9.6 9.6 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 9.08 9.08 9.08 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.04 8.04 8.04 Drug Central
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.22 8.22 8.22 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.18 8.18 8.18 Drug Central
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.2 8.2 8.2 Drug Central
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.24 8.24 8.24 Drug Central
α1D ADA1D Human Adrenoceptors A pKi 8.04 8.04 8.04 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.23 8.23 8.23 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.16 8.16 8.16 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.18 8.18 8.18 Drug Central
D2 DRD2 Human Dopamine A pKi 8.02 8.02 8.02 Drug Central
D3 DRD3 Human Dopamine A pKi 8.04 8.04 8.04 Drug Central
D4 DRD4 Human Dopamine A pKi 8.04 8.04 8.04 Drug Central
H1 HRH1 Human Histamine A pKi 8.2 8.2 8.2 Drug Central
α1B ADA1B Rat Adrenoceptors A pKi 8.1 8.1 8.1 Drug Central
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.16 8.16 8.16 Drug Central
D1 DRD1 Human Dopamine A pKi 8.2 8.2 8.2 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1B ADA1B Rat Adrenoceptors A pIC50 7.75 7.75 7.75 ChEMBL
α1A ADA1A Rat Adrenoceptors A pIC50 8.78 8.78 8.78 ChEMBL
α1D ADA1D Human Adrenoceptors A pIC50 7.08 7.08 7.08 ChEMBL
α2B ADA2B Human Adrenoceptors A pIC50 6.66 6.66 6.66 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pIC50 5.64 5.64 5.64 ChEMBL
α2C ADA2C Human Adrenoceptors A pIC50 5.75 5.75 5.75 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pIC50 5.42 5.42 5.42 ChEMBL
H1 HRH1 Human Histamine A pIC50 5.34 5.34 5.34 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 6.62 6.62 6.62 ChEMBL
α2A ADA2A Human Adrenoceptors A pIC50 5.53 5.53 5.53 ChEMBL
D1 DRD1 Human Dopamine A pIC50 5.96 5.96 5.96 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 5.87 5.87 5.87 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 6.34 6.34 6.34 ChEMBL
D3 DRD3 Human Dopamine A pIC50 8.56 8.56 8.56 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 8.59 8.59 8.59 ChEMBL
D2 DRD2 Human Dopamine A pIC50 8.62 8.62 8.62 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 8.18 8.18 8.18 Drug Central
α1A ADA1A Rat Adrenoceptors A pIC50 8.06 8.06 8.06 Drug Central