mepyramine
| SMILES | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C |
| InChIKey | YECBIJXISLIIDS-UHFFFAOYSA-N |
Chemical properties
| Hydrogen bond acceptors | 4 |
| Hydrogen bond donors | 0 |
| Rotatable bonds | 7 |
| Molecular weight (Da) | 285.2 |
Drug properties
| Molecular type | Small molecule |
| Physiological/Surrogate | Surrogate |
| Approved drug | Yes |
Database connections
| Ligand site mutations | H1 |
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| H1 | HRH1 | Human | Histamine | A | pKi | 8.7 | 8.85 | 9.0 | Guide to Pharmacology |
| H1 | HRH1 | Guinea pig | Histamine | A | pKd | 8.84 | 9.12 | 9.5 | ChEMBL |
| H1 | HRH1 | Human | Histamine | A | pKi | 8.35 | 8.85 | 9.37 | ChEMBL |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 5.95 | 5.95 | 5.95 | ChEMBL |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 5.75 | 5.75 | 5.75 | ChEMBL |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 6.23 | 6.23 | 6.23 | ChEMBL |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 6.54 | 6.54 | 6.54 | ChEMBL |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 5.7 | 5.7 | 5.7 | PDSP Ki database |
| 5-HT2A | 5HT2A | Rat | 5-Hydroxytryptamine | A | pKi | 5.97 | 6.12 | 6.48 | PDSP Ki database |
| H1 | HRH1 | Human | Histamine | A | pKi | 5.0 | 8.43 | 9.28 | PDSP Ki database |
| H1 | HRH1 | Guinea pig | Histamine | A | pKi | 8.9 | 9.14 | 9.3 | PDSP Ki database |
| H3 | HRH3 | Rat | Histamine | A | pKi | 5.0 | 5.03 | 5.1 | PDSP Ki database |
| H1 | HRH1 | Rat | Histamine | A | pKi | 8.35 | 8.35 | 8.35 | PDSP Ki database |
| H3 | HRH3 | Human | Histamine | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| H1 | HRH1 | Mouse | Histamine | A | pKi | 8.49 | 8.49 | 8.49 | PDSP Ki database |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 8.21 | 8.21 | 8.21 | Drug Central |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 8.23 | 8.23 | 8.23 | Drug Central |
| H1 | HRH1 | Human | Histamine | A | pKi | 8.04 | 8.04 | 8.04 | Drug Central |
| H1 | HRH1 | Guinea pig | Histamine | A | pKd | 8.02 | 8.02 | 8.02 | Drug Central |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 8.24 | 8.24 | 8.24 | Drug Central |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 8.24 | 8.24 | 8.24 | Drug Central |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| H1 | HRH1 | Rat | Histamine | A | pIC50 | 8.24 | 8.24 | 8.24 | ChEMBL |
| H1 | HRH1 | Guinea pig | Histamine | A | pIC50 | 7.47 | 8.14 | 8.82 | ChEMBL |
| M1 | ACM1 | Rat | Acetylcholine (muscarinic) | A | Potency | 4.8 | 4.88 | 4.95 | ChEMBL |
| H1 | HRH1 | Human | Histamine | A | pIC50 | 6.8 | 8.51 | 10.85 | ChEMBL |
| H1 | HRH1 | Human | Histamine | A | pEC50 | 8.59 | 8.59 | 8.59 | ChEMBL |
| α2A | ADA2A | Human | Adrenoceptors | A | pIC50 | 5.53 | 5.53 | 5.53 | ChEMBL |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pIC50 | 5.55 | 5.55 | 5.55 | ChEMBL |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pIC50 | 5.95 | 5.95 | 5.95 | ChEMBL |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pIC50 | 6.0 | 6.0 | 6.0 | ChEMBL |
| TSH | TSHR | Human | Glycoprotein hormone | A | Potency | 4.4 | 4.83 | 5.3 | ChEMBL |
| A3 | AA3R | Human | Adenosine | A | pIC50 | 8.05 | 8.05 | 8.05 | Drug Central |
| H1 | HRH1 | Rat | Histamine | A | pIC50 | 8.08 | 8.08 | 8.08 | Drug Central |