CHEMBL246852


SMILES COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4C(F)(F)F)cc13)CC2
InChIKey RDAVKEYAUFGPDX-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 6
Molecular weight (Da) 497.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2B ADA2B Human Adrenoceptors A pKi 6.02 6.02 6.02 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 7.75 7.75 7.75 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 6.52 6.52 6.52 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 6.02 6.02 6.02 PDSP Ki database
α2C ADA2C Human Adrenoceptors A pKi 7.74 7.74 7.74 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 6.52 6.52 6.52 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database