naratriptan


SMILES CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C
InChIKey AMKVXSZCKVJAGH-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 5
Molecular weight (Da) 335.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.1 7.35 7.6 Guide to Pharmacology
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 8.1 8.1 8.1 Guide to Pharmacology
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.4 8.7 9.0 Guide to Pharmacology
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 7.7 7.7 7.7 Guide to Pharmacology
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 8.2 8.2 8.2 Guide to Pharmacology
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 8.48 8.48 8.48 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.64 8.64 8.64 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 8.03 8.16 8.29 PDSP Ki database
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.82 8.82 8.82 PDSP Ki database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 8.07 8.07 8.07 Drug Central
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 8.11 8.11 8.11 Drug Central
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 8.09 8.09 8.09 Drug Central
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.13 8.13 8.13 Drug Central
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.35 7.35 7.35 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pEC50 8.8 8.8 8.8 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pEC50 8.06 8.06 8.06 Drug Central