clozapine


SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2
InChIKey QZUDBNBUXVUHMW-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 0
Molecular weight (Da) 326.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Structure pdb 8JXV
Ligand site mutations 5-HT2A 5-HT2C 5-HT6 5-HT7 D1 D2 D4 H4 M1

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.8 6.85 6.9 Guide to Pharmacology
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 6.2 6.2 6.2 Guide to Pharmacology
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 6.4 6.4 6.4 Guide to Pharmacology
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 6.4 6.4 6.4 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.0 8.4 8.8 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.4 8.05 8.7 Guide to Pharmacology
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 6.0 6.25 6.5 Guide to Pharmacology
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 7.8 7.95 8.1 Guide to Pharmacology
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.2 7.5 7.8 Guide to Pharmacology
α1B ADA1B Human Adrenoceptors A pKi 7.4 7.8 8.2 Guide to Pharmacology
α1D ADA1D Human Adrenoceptors A pKi 7.7 7.7 7.7 Guide to Pharmacology
D1 DRD1 Human Dopamine A pKi 6.9 6.9 6.9 Guide to Pharmacology
D2 DRD2 Human Dopamine A pKi 5.8 6.35 6.9 Guide to Pharmacology
D3 DRD3 Human Dopamine A pKi 5.2 5.75 6.3 Guide to Pharmacology
D4 DRD4 Human Dopamine A pKi 7.5 7.5 7.5 Guide to Pharmacology
H1 HRH1 Human Histamine A pKi 8.8 9.2 9.6 Guide to Pharmacology
H4 HRH4 Human Histamine A pKi 6.2 6.45 6.7 Guide to Pharmacology
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 7.5 7.95 8.4 Guide to Pharmacology
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 8.9 8.9 8.9 Guide to Pharmacology
D3 DRD3 Rat Dopamine A pKi 5.7 5.7 5.7 Guide to Pharmacology
H4 HRH4 Mouse Histamine A pKi 5.5 5.5 5.5 Guide to Pharmacology
H4 HRH4 Rat Histamine A pKi 5.7 5.7 5.7 Guide to Pharmacology
H3 HRH3 Rat Histamine A pKi 5.8 5.8 5.8 Guide to Pharmacology
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 7.2 7.7 8.2 Guide to Pharmacology
D2 DRD2 Rat Dopamine A pKi 6.2 6.2 6.2 Guide to Pharmacology
5-HT5A 5HT5A Mouse 5-Hydroxytryptamine A pKi 5.3 5.3 5.3 Guide to Pharmacology
α2A ADA2A Rat Adrenoceptors A pKi 7.0 7.36 7.72 ChEMBL
H1 HRH1 Rat Histamine A pKi 7.85 8.23 8.54 ChEMBL
D4 DRD4 Rat Dopamine A pKi 7.5 7.7 8.05 ChEMBL
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKd 6.77 6.83 6.9 ChEMBL
D1 DRD1 Bovine Dopamine A pKi 6.38 6.38 6.38 ChEMBL
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 ChEMBL
D2 DRD2 Bovine Dopamine A pKi 6.16 6.16 6.16 ChEMBL
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 7.2 7.77 8.2 ChEMBL
D3 DRD3 Rat Dopamine A pKi 6.3 6.56 6.79 ChEMBL
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 7.38 7.75 8.1 ChEMBL
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 ChEMBL
D5 DRD5 Human Dopamine A pKi 6.0 6.36 6.7 ChEMBL
D1 DRD1 Rat Dopamine A pKi 6.27 6.65 7.37 ChEMBL
H1 HRH1 Guinea pig Histamine A pKi 7.91 8.14 8.42 ChEMBL
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 6.02 6.02 6.02 ChEMBL
α1B ADA1B Rat Adrenoceptors A pKi 7.54 7.88 8.45 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 8.0 8.0 8.0 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKi 7.66 7.74 7.82 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 7.26 7.74 8.68 ChEMBL
H4 HRH4 Human Histamine A pKi 6.3 6.58 6.75 ChEMBL
H4 HRH4 Human Histamine A pKd 7.15 7.65 7.92 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 7.77 7.77 7.77 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 7.0 7.48 7.96 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 7.0 7.51 8.02 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 7.0 8.16 8.94 ChEMBL
H2 HRH2 Human Histamine A pKi 5.45 5.45 5.45 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.0 7.64 8.26 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 7.0 7.7 8.2 ChEMBL
H1 HRH1 Human Histamine A pKi 7.77 8.68 9.24 ChEMBL
H1 HRH1 Human Histamine A pKd 8.51 8.51 8.51 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 7.0 7.38 7.77 ChEMBL
D2 DRD2 Rat Dopamine A pKi 6.1 6.89 7.47 ChEMBL
D4 DRD4 Human Dopamine A pKi 5.05 7.58 8.0 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 7.72 7.81 8.0 ChEMBL
α1A ADA1A Human Adrenoceptors A pKd 7.43 7.43 7.43 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.19 6.79 7.42 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 6.0 6.96 7.62 ChEMBL
D1 DRD1 Human Dopamine A pKi 6.0 7.04 8.12 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 7.0 8.1 8.4 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.14 8.32 8.5 ChEMBL
H3 HRH3 Human Histamine A pKi 6.2 6.2 6.2 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 6.77 6.88 7.0 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.0 7.91 8.54 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 7.0 8.38 9.01 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.0 6.4 7.06 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.64 8.06 8.92 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.0 6.87 8.2 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.0 7.01 8.15 ChEMBL
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 7.41 7.89 8.3 PDSP Ki database
α1D ADA1D Human Adrenoceptors A pKi 8.11 8.11 8.11 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.07 8.07 8.07 Drug Central
β1 ADRB1 Human Adrenoceptors A pKi 8.28 8.28 8.28 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.09 8.17 9.26 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 7.21 8.09 8.59 PDSP Ki database
5-HT2A 5HT2A Bovine 5-Hydroxytryptamine A pKi 7.79 7.79 7.79 PDSP Ki database
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 7.51 8.02 8.4 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 7.21 7.68 8.2 PDSP Ki database
D1 DRD1 Rat Dopamine A pKi 6.06 6.61 7.28 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 5.83 6.84 8.06 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.16 7.88 8.88 PDSP Ki database
D1 DRD1 Human Dopamine A pKi 6.27 6.67 7.05 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 6.37 6.89 7.55 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 6.02 6.61 7.57 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 7.26 7.77 8.8 PDSP Ki database
D5 DRD5 Human Dopamine A pKi 6.55 6.62 6.7 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 7.77 8.0 8.4 PDSP Ki database
D4 DRD4 Rat Dopamine A pKi 7.49 7.68 8.02 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.99 8.2 8.46 PDSP Ki database
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKi 7.5 7.5 7.5 PDSP Ki database
α2C ADA2C Human Adrenoceptors A pKi 7.47 7.89 8.54 PDSP Ki database
α2B ADA2B Rat Adrenoceptors A pKi 7.08 7.62 8.16 PDSP Ki database
5-HT7 5HT7R Guinea pig 5-Hydroxytryptamine A pKi 6.83 7.08 7.32 PDSP Ki database
5-HT6 5HT6R Mouse 5-Hydroxytryptamine A pKi 7.4 7.7 8.19 PDSP Ki database
D2 A0A287B0Q7 Pig Dopamine A pKi 5.92 6.58 7.01 PDSP Ki database
D3 DRD3 Rat Dopamine A pKi 6.19 6.55 7.08 PDSP Ki database
H3 HRH3 Human Histamine A pKi 5.0 5.25 6.0 PDSP Ki database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.77 6.42 6.82 PDSP Ki database
H3 HRH3 Rat Histamine A pKi 5.52 5.64 5.76 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.48 5.72 5.92 PDSP Ki database
5-HT7 5HT7R Mouse 5-Hydroxytryptamine A pKi 7.4 7.59 7.68 PDSP Ki database
5-HT2C K7GSR7 Pig 5-Hydroxytryptamine A pKi 7.89 8.16 8.54 PDSP Ki database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 5.68 6.17 6.41 PDSP Ki database
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 5.0 5.8 6.37 PDSP Ki database
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 6.89 6.89 6.89 PDSP Ki database
α2B ADA2B Human Adrenoceptors A pKi 7.57 7.6 7.66 PDSP Ki database
β1 ADRB1 Human Adrenoceptors A pKi 5.0 5.15 5.3 PDSP Ki database
H1 HRH1 Human Histamine A pKi 6.7 8.73 9.64 PDSP Ki database
H4 HRH4 Human Histamine A pKi 6.07 6.34 6.7 PDSP Ki database
D1 DRD1 Bovine Dopamine A pKi 5.55 5.67 5.72 PDSP Ki database
H1 HRH1 Rat Histamine A pKi 7.39 7.79 8.54 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 7.51 8.36 8.85 PDSP Ki database
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 6.96 7.59 8.15 PDSP Ki database
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 7.54 7.85 8.22 PDSP Ki database
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 7.03 7.79 8.3 PDSP Ki database
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 6.69 7.16 7.85 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.59 6.86 6.98 PDSP Ki database
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.67 6.28 6.89 PDSP Ki database
α1A Q9TSW7 Pig Adrenoceptors A pKi 6.2 7.63 8.5 PDSP Ki database
β2 ADRB2 Rat Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
H1 HRH1 Guinea pig Histamine A pKi 7.64 8.46 8.91 PDSP Ki database
D2 DRD2 Bovine Dopamine A pKi 6.92 7.06 7.19 PDSP Ki database
AT1 AGTR1 Human Angiotensin A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT4 5HT4R Guinea pig 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
A1 AA1R Rat Adenosine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1D F1MMU1 Bovine 5-Hydroxytryptamine A pKi 5.8 5.99 6.15 PDSP Ki database
α1D ADA1D Rat Adrenoceptors A pKi 8.11 8.11 8.11 PDSP Ki database
α1B ADA1B Rat Adrenoceptors A pKi 8.51 8.51 8.51 PDSP Ki database
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 5.41 5.71 6.0 PDSP Ki database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 5.0 7.28 7.75 PDSP Ki database
α1B ADA1B Human Adrenoceptors A pKi 8.15 8.15 8.15 PDSP Ki database
α1D ADA1D Human Adrenoceptors A pKi 7.72 8.58 8.8 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 6.85 7.17 7.62 PDSP Ki database
β2 ADRB2 Human Adrenoceptors A pKi 5.0 5.39 5.78 PDSP Ki database
H2 HRH2 Human Histamine A pKi 6.82 6.82 6.82 PDSP Ki database
EP3 PE2R3 Human Prostanoid A pKi 5.0 5.0 5.0 PDSP Ki database
EP4 PE2R4 Human Prostanoid A pKi 5.0 5.0 5.0 PDSP Ki database
CB1 CNR1 Rat Cannabinoid A pKi 5.0 5.0 5.0 PDSP Ki database
H3 HRH3 Guinea pig Histamine A pKi 5.2 5.2 5.2 PDSP Ki database
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 7.26 8.0 8.72 PDSP Ki database
M4 ACM4 Rat Acetylcholine (muscarinic) A pKi 7.74 7.74 7.74 PDSP Ki database
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 8.0 8.0 8.0 PDSP Ki database
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 7.59 7.76 7.85 PDSP Ki database
D1 DRD1 Mouse Dopamine A pKi 7.26 7.26 7.26 PDSP Ki database
TP TA2R Human Prostanoid A pKi 6.0 6.0 6.0 PDSP Ki database
δ OPRD Mouse Opioid A pKi 6.0 6.0 6.0 PDSP Ki database
CCK2 GASR Rat Cholecystokinin A pKi 6.0 6.0 6.0 PDSP Ki database
κ OPRK Guinea pig Opioid A pKi 6.0 6.0 6.0 PDSP Ki database
D3 F1N454 Bovine Dopamine A pKi 6.06 6.23 6.4 PDSP Ki database
D1 DRD1 Pig Dopamine A pKi 6.58 6.58 6.58 PDSP Ki database
D1 DRD1 Rhesus macaque Dopamine A pKi 6.39 6.39 6.39 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 8.15 8.15 8.15 Drug Central
β2 ADRB2 Human Adrenoceptors A pKi 8.24 8.24 8.24 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.13 8.13 8.13 Drug Central
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 8.21 8.21 8.21 Drug Central
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.19 8.19 8.19 Drug Central
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 8.19 8.19 8.19 Drug Central
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 8.16 8.16 8.16 Drug Central
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.08 8.08 8.08 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.09 8.09 8.09 Drug Central
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.1 8.1 8.1 Drug Central
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.11 8.11 8.11 Drug Central
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.14 8.14 8.14 Drug Central
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.12 8.12 8.12 Drug Central
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.11 8.11 8.11 Drug Central
α1A ADA1A Human Adrenoceptors A pKi 8.09 8.09 8.09 Drug Central
α1B ADA1B Human Adrenoceptors A pKi 8.1 8.1 8.1 Drug Central
D1 DRD1 Human Dopamine A pKi 8.16 8.16 8.16 Drug Central
D3 DRD3 Human Dopamine A pKi 8.18 8.18 8.18 Drug Central
D4 DRD4 Human Dopamine A pKi 8.12 8.12 8.12 Drug Central
D5 DRD5 Human Dopamine A pKi 8.18 8.18 8.18 Drug Central
H1 HRH1 Human Histamine A pKi 8.04 8.04 8.04 Drug Central
H2 HRH2 Human Histamine A pKi 8.17 8.17 8.17 Drug Central
α1B ADA1B Rat Adrenoceptors A pKi 8.07 8.07 8.07 Drug Central
D3 DRD3 Rat Dopamine A pKi 8.17 8.17 8.17 Drug Central
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 8.09 8.09 8.09 Drug Central
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 8.13 8.13 8.13 Drug Central
H4 HRH4 Mouse Histamine A pKi 8.26 8.26 8.26 Drug Central
5-HT7 5HT7R Mouse 5-Hydroxytryptamine A pKi 8.13 8.13 8.13 Drug Central
D1 DRD1 Bovine Dopamine A pKi 8.2 8.2 8.2 Drug Central
D1 DRD1 Pig Dopamine A pKi 8.2 8.2 8.2 Drug Central
α1A ADA1A Rat Adrenoceptors A pKi 8.12 8.12 8.12 Drug Central
H1 HRH1 Guinea pig Histamine A pKi 8.07 8.07 8.07 Drug Central
H4 HRH4 Rat Histamine A pKi 8.24 8.24 8.24 Drug Central
D2 DRD2 Bovine Dopamine A pKi 8.21 8.21 8.21 Drug Central
H1 HRH1 Rat Histamine A pKi 8.07 8.07 8.07 Drug Central
H3 HRH3 Rat Histamine A pKi 8.24 8.24 8.24 Drug Central
D2 DRD2 Green monkey Dopamine A pKi 8.18 8.18 8.18 Drug Central
D1 DRD1 Rat Dopamine A pKi 8.13 8.13 8.13 Drug Central
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 8.09 8.09 8.09 Drug Central
D3 DRD3 Green monkey Dopamine A pKi 8.2 8.2 8.2 Drug Central
D4 DRD4 Rat Dopamine A pKi 8.09 8.09 8.09 Drug Central
D2 DRD2 Rat Dopamine A pKi 8.13 8.13 8.13 Drug Central
5-HT5A 5HT5A Mouse 5-Hydroxytryptamine A pKi 8.28 8.28 8.28 Drug Central
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 8.06 8.06 8.06 Drug Central
β1 ADRB1 Rat Adrenoceptors A pKi 8.34 8.34 8.34 Drug Central
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.09 8.09 8.09 Drug Central
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 6.9 6.9 6.9 Guide to Pharmacology
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.6 8.3 9.0 Guide to Pharmacology
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.08 8.08 8.08 Drug Central
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 8.22 8.22 8.22 Drug Central
α1A ADA1A Human Adrenoceptors A pKi 8.1 8.2 8.3 Guide to Pharmacology
D2 DRD2 Human Dopamine A pKi 8.16 8.16 8.16 Drug Central
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 8.08 8.08 8.08 Drug Central
D5 DRD5 Human Dopamine A pKi 6.6 6.6 6.6 Guide to Pharmacology
H4 HRH4 Human Histamine A pKi 8.08 8.08 8.08 Drug Central
PAF PTAFR Human Platelet-activating factor A pKi 6.0 6.0 6.0 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 8.09 8.09 8.09 Drug Central
μ OPRM Rat Opioid A pKi 6.0 6.0 6.0 PDSP Ki database
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 7.34 7.34 7.34 ChEMBL
5-HT7 5HT7R Mouse 5-Hydroxytryptamine A pKi 7.4 7.4 7.4 Guide to Pharmacology
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 8.13 8.13 8.13 Drug Central
D2 DRD2 Mouse Dopamine A pKi 7.05 7.05 7.05 PDSP Ki database
D1 DRD1 Pig Dopamine A pKi 6.38 6.38 6.38 ChEMBL
D2 DRD2 Green monkey Dopamine A pKi 6.59 6.59 6.59 ChEMBL
α2A ADA2A Rat Adrenoceptors A pKi 8.11 8.11 8.11 Drug Central
D3 DRD3 Green monkey Dopamine A pKi 6.33 6.33 6.33 ChEMBL
β1 ADRB1 Rat Adrenoceptors A pKi 4.58 4.58 4.58 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Human Acetylcholine (muscarinic) A pIC50 7.9 7.9 7.9 Guide to Pharmacology
5-HT2A 5HT2A Bovine 5-Hydroxytryptamine A pIC50 8.52 8.52 8.52 ChEMBL
5-HT1A 5HT1A Mouse 5-Hydroxytryptamine A pIC50 5.7 5.7 5.7 ChEMBL
H1 HRH1 Rat Histamine A pIC50 7.64 7.78 8.05 ChEMBL
D2 DRD2 Bovine Dopamine A pIC50 6.35 6.6 6.85 ChEMBL
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pIC50 7.96 7.96 7.96 ChEMBL
D1 DRD1 Rat Dopamine A pIC50 6.72 6.82 6.89 ChEMBL
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pIC50 5.6 5.64 5.68 ChEMBL
α1B ADA1B Rat Adrenoceptors A pIC50 8.19 8.19 8.19 ChEMBL
α1A ADA1A Rat Adrenoceptors A pIC50 7.42 7.42 7.42 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 7.0 7.25 7.5 ChEMBL
α1D ADA1D Human Adrenoceptors A pIC50 7.46 7.46 7.46 ChEMBL
α2B ADA2B Human Adrenoceptors A pIC50 7.64 7.64 7.64 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pIC50 7.89 7.89 7.89 ChEMBL
α2C ADA2C Human Adrenoceptors A pIC50 8.1 8.1 8.1 ChEMBL
H2 HRH2 Human Histamine A pIC50 5.44 5.44 5.44 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pIC50 7.35 7.35 7.35 ChEMBL
H1 HRH1 Human Histamine A pIC50 8.31 8.31 8.31 ChEMBL
H1 HRH1 Human Histamine A pEC50 9.4 9.4 9.4 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pIC50 7.11 7.11 7.11 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 5.56 6.35 7.42 ChEMBL
D4 DRD4 Human Dopamine A pIC50 6.78 7.21 7.77 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 5.7 6.05 6.57 ChEMBL
α2A ADA2A Human Adrenoceptors A pIC50 7.05 7.05 7.05 ChEMBL
D1 DRD1 Human Dopamine A pIC50 6.97 6.97 6.97 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pIC50 7.69 7.78 7.96 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 7.96 7.96 7.96 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pEC50 7.7 7.7 7.7 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pIC50 6.32 6.32 6.32 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 8.0 8.11 8.22 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pEC50 6.6 6.6 6.6 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pIC50 8.0 8.02 8.03 ChEMBL
D3 DRD3 Human Dopamine A pIC50 6.35 6.47 6.59 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 7.92 8.15 8.38 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pIC50 6.82 6.82 6.82 ChEMBL
D2 DRD2 Human Dopamine A pIC50 6.41 6.86 8.05 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pIC50 8.09 8.09 8.09 Drug Central
M4 ACM4 Human Acetylcholine (muscarinic) A pEC50 8.14 8.14 8.14 Drug Central
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pIC50 8.25 8.25 8.25 Drug Central
D2 DRD2 Mouse Dopamine A pIC50 8.18 8.18 8.18 Drug Central
5-HT2A 5HT2A Bovine 5-Hydroxytryptamine A pIC50 8.07 8.07 8.07 Drug Central
5-HT1A 5HT1A Mouse 5-Hydroxytryptamine A pIC50 8.24 8.24 8.24 Drug Central
α1A ADA1A Bovine Adrenoceptors A pIC50 8.17 8.17 8.17 Drug Central
TSH TSHR Human Glycoprotein hormone A Potency 4.5 4.5 4.5 ChEMBL
A3 AA3R Human Adenosine A pIC50 8.17 8.17 8.17 Drug Central
D2 DRD2 Mouse Dopamine A pIC50 6.54 6.54 6.54 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A pIC50 7.7 7.7 7.7 Guide to Pharmacology
α1A ADA1A Bovine Adrenoceptors A pIC50 6.8 6.8 6.8 ChEMBL