CHEMBL2376801


SMILES CCc1cnc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1
InChIKey QEDDBMMRWNQKSG-SNVBAGLBSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 3
Molecular weight (Da) 272.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Mouse Histamine A pKi 7.07 7.07 7.07 ChEMBL
H4 HRH4 Rat Histamine A pKi 6.86 6.86 6.86 ChEMBL
H4 HRH4 Human Histamine A pKi 8.04 8.04 8.04 ChEMBL
H4 HRH4 Human Histamine A pKd 7.67 7.67 7.67 ChEMBL
H2 HRH2 Human Histamine A pKi 5.5 5.5 5.5 ChEMBL
H1 HRH1 Human Histamine A pKi 4.95 4.95 4.95 ChEMBL
H3 HRH3 Human Histamine A pKi 5.82 5.82 5.82 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Human Histamine A pIC50 6.9 6.9 6.9 ChEMBL