pirenperone


SMILES Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2
InChIKey HXCNRYXBZNHDNE-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 5
Molecular weight (Da) 393.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.2 8.35 8.5 Guide to Pharmacology
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.18 5.18 5.18 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.22 7.22 7.22 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKd 5.6 5.6 5.6 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.11 7.2 7.28 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 7.82 7.82 7.82 PDSP Ki database
5-HT2C K7GSR7 Pig 5-Hydroxytryptamine A pKi 7.22 7.52 8.3 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.0 5.14 5.25 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.97 8.97 8.97 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.21 7.21 7.21 PDSP Ki database
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKi 6.22 6.22 6.22 PDSP Ki database
5-HT7 5HT7R Guinea pig 5-Hydroxytryptamine A pKi 7.28 7.51 7.74 PDSP Ki database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.6 5.86 6.01 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.2 6.25 6.31 PDSP Ki database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.77 5.77 5.77 ChEMBL
5-HT1A A0A4X1UTF5 Pig 5-Hydroxytryptamine A pKi 6.06 6.06 6.06 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.85 4.95 5.05 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 5.4 5.4 5.4 ChEMBL