prazosin


SMILES COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1
InChIKey IENZQIKPVFGBNW-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 383.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Ligand site mutations α1A α1B α2A

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1A ADA1A Human Adrenoceptors A pKi 9.0 9.45 9.9 Guide to Pharmacology
α1A ADA1A Human Adrenoceptors A pKd 9.1 9.1 9.1 Guide to Pharmacology
α1B ADA1B Human Adrenoceptors A pKi 8.7 9.3 9.9 Guide to Pharmacology
α1B ADA1B Human Adrenoceptors A pKd 9.1 9.1 9.1 Guide to Pharmacology
α1D ADA1D Human Adrenoceptors A pKi 9.1 9.18 10.2 Guide to Pharmacology
α2A ADA2A Human Adrenoceptors A pKi 5.3 5.9 6.5 Guide to Pharmacology
α1A ADA1A Rat Adrenoceptors A pKi 9.5 9.5 9.5 Guide to Pharmacology
α2C ADA2C Human Adrenoceptors A pKi 6.5 7.25 8.0 Guide to Pharmacology
α2A ADA2A Pig Adrenoceptors A pKi 5.39 5.39 5.39 ChEMBL
α2A ADA2A Bovine Adrenoceptors A pKi 6.97 6.97 6.97 ChEMBL
α1B ADA1B Golden hamster Adrenoceptors A pKi 9.08 9.08 9.08 ChEMBL
α2A ADA2A Rat Adrenoceptors A pKi 5.78 5.78 5.78 ChEMBL
α1A ADA1A Rabbit Adrenoceptors A pKd 8.3 8.3 8.3 ChEMBL
α1A ADA1A Bovine Adrenoceptors A pKi 9.03 9.46 9.9 ChEMBL
α1D ADA1D Rat Adrenoceptors A pKd 8.7 9.06 9.77 ChEMBL
α1D ADA1D Rat Adrenoceptors A pKi 8.86 9.29 9.7 ChEMBL
α1B ADA1B Rat Adrenoceptors A pKi 8.53 9.59 10.0 ChEMBL
α1B ADA1B Rat Adrenoceptors A pKd 8.99 9.0 9.01 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 9.48 9.48 9.48 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 8.1 9.33 9.68 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKd 8.6 9.0 9.81 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKi 8.98 9.56 10.15 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 9.34 9.55 9.77 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 6.44 7.07 7.89 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 7.02 7.22 7.62 ChEMBL
D4 DRD4 Human Dopamine A pKi 5.08 5.08 5.08 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 8.73 9.4 10.4 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.63 5.63 5.63 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 5.67 6.12 6.68 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.58 5.58 5.58 ChEMBL
5-HT2C K7GSR7 Pig 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.1 5.82 6.54 PDSP Ki database
5-HT1D F1MMU1 Bovine 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.15 6.92 10.15 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 5.0 5.72 6.48 PDSP Ki database
5-HT2A 5HT2A Pig 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 5.65 6.16 6.52 PDSP Ki database
α2C ADA2C Human Adrenoceptors A pKi 7.24 7.7 7.97 PDSP Ki database
α2B ADA2B Human Adrenoceptors A pKi 6.94 7.4 7.84 PDSP Ki database
α2B ADA2B Rat Adrenoceptors A pKi 7.94 8.11 8.27 PDSP Ki database
α1B ADA1B Human Adrenoceptors A pKi 9.21 9.72 10.22 PDSP Ki database
α1D ADA1D Rat Adrenoceptors A pKi 9.48 9.48 9.48 PDSP Ki database
MT1 MTR1A Human Melatonin A pKi 5.0 5.0 5.0 PDSP Ki database
MT2 MTR1B Human Melatonin A pKi 5.0 5.0 5.0 PDSP Ki database
α1D ADA1D Human Adrenoceptors A pKi 9.16 9.74 10.22 PDSP Ki database
α2A ADA2A Pig Adrenoceptors A pKi 5.94 5.94 5.94 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 5.0 5.01 5.06 PDSP Ki database
α1A Q9TSW7 Pig Adrenoceptors A pKi 9.2 9.33 9.6 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.11 8.11 8.11 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.18 8.18 8.18 Drug Central
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.02 8.02 8.02 Drug Central
α1A ADA1A Human Adrenoceptors A pKi 7.98 7.98 7.98 Drug Central
α1B ADA1B Human Adrenoceptors A pKi 8.01 8.01 8.01 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.1 8.1 8.1 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.12 8.12 8.12 Drug Central
D4 DRD4 Human Dopamine A pKi 8.29 8.29 8.29 Drug Central
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 8.24 8.24 8.24 Drug Central
α1D ADA1D Rat Adrenoceptors A pKi 8.01 8.01 8.01 Drug Central
μ OPRM Rat Opioid A pKi 8.01 8.01 8.01 Drug Central
α1B ADA1B Rat Adrenoceptors A pKi 8.0 8.0 8.0 Drug Central
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 8.25 8.25 8.25 Drug Central
α1A ADA1A Rat Adrenoceptors A pKi 7.99 7.99 7.99 Drug Central
α2A ADA2A Pig Adrenoceptors A pKi 8.27 8.27 8.27 Drug Central
α2A ADA2A Bovine Adrenoceptors A pKi 8.16 8.16 8.16 Drug Central
α2A ADA2A Rat Adrenoceptors A pKi 8.24 8.24 8.24 Drug Central
α1B ADA1B Golden hamster Adrenoceptors A pKi 8.04 8.04 8.04 Drug Central
α1A ADA1A Bovine Adrenoceptors A pKi 8.01 8.01 8.01 Drug Central
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.0 5.61 6.31 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.25 8.25 8.25 Drug Central
α1D ADA1D Human Adrenoceptors A pKi 8.01 8.01 8.01 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 6.2 6.85 7.5 Guide to Pharmacology
α1B ADA1B Rat Adrenoceptors A pKi 9.25 9.25 9.25 PDSP Ki database
α2C ADA2C North American opossum Adrenoceptors A pKi 7.44 7.44 7.44 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1B ADA1B Rat Adrenoceptors A pIC50 9.07 9.53 9.75 ChEMBL
α1A ADA1A Rat Adrenoceptors A pIC50 9.16 9.47 9.66 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.55 4.7 4.85 ChEMBL
α1D ADA1D Human Adrenoceptors A pIC50 9.06 9.12 9.18 ChEMBL
α2B ADA2B Human Adrenoceptors A pIC50 6.54 6.54 6.54 ChEMBL
α2C ADA2C Human Adrenoceptors A pIC50 6.19 6.19 6.19 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 4.96 4.96 4.96 ChEMBL
α2A ADA2A Human Adrenoceptors A pIC50 5.58 5.58 5.58 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 5.38 5.38 5.38 ChEMBL
A3 AA3R Human Adenosine A pIC50 8.04 8.04 8.04 Drug Central
D2 DRD2 Rat Dopamine A pIC50 8.3 8.3 8.3 Drug Central