Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
AssayType |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
| 10696930 | 36088 | 0 | None | - | 1 | Human | 10.1 | pEC50 | = | 10.1 | Functional | ChEMBL | 506 | 14 | 6 | 6 | 1.7 | NCCc1c[nH]c2ccc(OCC(=O)NCCCNC(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | ||
| CHEMBL144397 | 36088 | 0 | None | - | 1 | Human | 10.1 | pEC50 | = | 10.1 | Functional | ChEMBL | 506 | 14 | 6 | 6 | 1.7 | NCCc1c[nH]c2ccc(OCC(=O)NCCCNC(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | ||
| 9897637 | 118932 | 0 | None | - | 1 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 828 | 25 | 6 | 8 | 7.2 | NCCc1c[nH]c2ccc(OCCCCCCNS(=O)(=O)c3ccc(-c4ccc(S(=O)(=O)NCCCCCCOc5ccc6[nH]cc(CCN)c6c5)cc4)cc3)cc12 | 10.1021/jm960552l | ||
| CHEMBL342323 | 118932 | 0 | None | - | 1 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 828 | 25 | 6 | 8 | 7.2 | NCCc1c[nH]c2ccc(OCCCCCCNS(=O)(=O)c3ccc(-c4ccc(S(=O)(=O)NCCCCCCOc5ccc6[nH]cc(CCN)c6c5)cc4)cc3)cc12 | 10.1021/jm960552l | ||
| 10791244 | 35797 | 0 | None | - | 1 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 490 | 12 | 4 | 6 | 2.7 | NCCc1c[nH]c2ccc(OCCN3CCN(CCOc4ccc5[nH]cc(CCN)c5c4)CC3)cc12 | 10.1021/jm960552l | ||
| CHEMBL144128 | 35797 | 0 | None | - | 1 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 490 | 12 | 4 | 6 | 2.7 | NCCc1c[nH]c2ccc(OCCN3CCN(CCOc4ccc5[nH]cc(CCN)c5c4)CC3)cc12 | 10.1021/jm960552l | ||
| 10720301 | 39984 | 0 | None | - | 1 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 504 | 11 | 4 | 6 | 2.3 | NCCc1c[nH]c2ccc(OCCN3CCN(C(=O)COc4ccc5[nH]cc(CCN)c5c4)CC3)cc12 | 10.1021/jm960552l | ||
| CHEMBL147851 | 39984 | 0 | None | - | 1 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 504 | 11 | 4 | 6 | 2.3 | NCCc1c[nH]c2ccc(OCCN3CCN(C(=O)COc4ccc5[nH]cc(CCN)c5c4)CC3)cc12 | 10.1021/jm960552l | ||
| 10531639 | 121272 | 0 | None | - | 1 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 600 | 11 | 4 | 6 | 3.6 | NCCc1c[nH]c2ccc(OCC(=O)N3CCC(C4CCN(C(=O)COc5ccc6[nH]cc(CCN)c6c5)CC4)CC3)cc12 | 10.1021/jm960552l | ||
| CHEMBL357830 | 121272 | 0 | None | - | 1 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 600 | 11 | 4 | 6 | 3.6 | NCCc1c[nH]c2ccc(OCC(=O)N3CCC(C4CCN(C(=O)COc5ccc6[nH]cc(CCN)c6c5)CC4)CC3)cc12 | 10.1021/jm960552l | ||
| 9984109 | 38877 | 0 | None | - | 1 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 518 | 10 | 4 | 6 | 1.8 | NCCc1c[nH]c2ccc(OCC(=O)N3CCN(C(=O)COc4ccc5[nH]cc(CCN)c5c4)CC3)cc12 | 10.1021/jm960552l | ||
| CHEMBL146720 | 38877 | 0 | None | - | 1 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 518 | 10 | 4 | 6 | 1.8 | NCCc1c[nH]c2ccc(OCC(=O)N3CCN(C(=O)COc4ccc5[nH]cc(CCN)c5c4)CC3)cc12 | 10.1021/jm960552l | ||
| 11800592 | 120985 | 0 | None | - | 1 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 540 | 12 | 6 | 6 | 3.7 | NCCc1c[nH]c2ccc(OCC(=O)Nc3ccc(NC(=O)COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12 | 10.1021/jm960552l | ||
| CHEMBL356277 | 120985 | 0 | None | - | 1 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 540 | 12 | 6 | 6 | 3.7 | NCCc1c[nH]c2ccc(OCC(=O)Nc3ccc(NC(=O)COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12 | 10.1021/jm960552l | ||
| 10008868 | 121125 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 609 | 12 | 5 | 7 | 3.4 | NCCc1c[nH]c2ccc(OCC(=O)Nc3ccc(N4CCN(C(=O)COc5ccc6[nH]cc(CCN)c6c5)CC4)cc3)cc12 | 10.1021/jm960552l | ||
| CHEMBL357478 | 121125 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 609 | 12 | 5 | 7 | 3.4 | NCCc1c[nH]c2ccc(OCC(=O)Nc3ccc(N4CCN(C(=O)COc5ccc6[nH]cc(CCN)c6c5)CC4)cc3)cc12 | 10.1021/jm960552l | ||
| 11797158 | 40040 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 435 | 11 | 5 | 5 | 2.2 | NCCc1c[nH]c2ccc(OCCNC(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | ||
| CHEMBL147901 | 40040 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 435 | 11 | 5 | 5 | 2.2 | NCCc1c[nH]c2ccc(OCCNC(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | ||
| 9832057 | 52315 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 692 | 16 | 2 | 6 | 4.8 | CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N(C)Cc3ccc(CN(C)S(=O)(=O)Cc4ccc5[nH]cc(CCN(C)C)c5c4)cc3)cc12 | 10.1016/s0960-894x(98)00090-0 | ||
| CHEMBL158941 | 52315 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 692 | 16 | 2 | 6 | 4.8 | CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N(C)Cc3ccc(CN(C)S(=O)(=O)Cc4ccc5[nH]cc(CCN(C)C)c5c4)cc3)cc12 | 10.1016/s0960-894x(98)00090-0 | ||
| 10836606 | 165533 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 434 | 13 | 4 | 4 | 4.7 | NCCc1c[nH]c2ccc(OCCCCCCOc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | ||
| CHEMBL424128 | 165533 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 434 | 13 | 4 | 4 | 4.7 | NCCc1c[nH]c2ccc(OCCCCCCOc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | ||
| 10647387 | 40191 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3cccc(COc4ccc5[nH]cc(CCN)c5c4)c3)cc12 | 10.1021/jm960552l | ||
| CHEMBL148022 | 40191 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3cccc(COc4ccc5[nH]cc(CCN)c5c4)c3)cc12 | 10.1021/jm960552l | ||
| 10837858 | 39806 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 464 | 12 | 6 | 5 | 2.4 | NCCc1c[nH]c2ccc(OCCNC(=O)NCCOc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | ||
| CHEMBL147677 | 39806 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 464 | 12 | 6 | 5 | 2.4 | NCCc1c[nH]c2ccc(OCCNC(=O)NCCOc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | ||
| 10671315 | 203011 | 0 | None | -186 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 451 | 8 | 1 | 5 | 4.6 | FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(OCc2ccccc2)CC1 | 10.1021/jm981133m | ||
| CHEMBL63258 | 203011 | 0 | None | -186 | 2 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 451 | 8 | 1 | 5 | 4.6 | FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(OCc2ccccc2)CC1 | 10.1021/jm981133m | ||
| 40 | 1547 | 58 | None | 1 | 8 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | 10.1016/j.ejmech.2021.114045 | ||
| 77993 | 1547 | 58 | None | 1 | 8 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | 10.1016/j.ejmech.2021.114045 | ||
| 995 | 1547 | 58 | None | 1 | 8 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | 10.1016/j.ejmech.2021.114045 | ||
| CHEMBL1510 | 1547 | 58 | None | 1 | 8 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | 10.1016/j.ejmech.2021.114045 | ||
| DB00216 | 1547 | 58 | None | 1 | 8 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | 10.1016/j.ejmech.2021.114045 | ||
| 18975369 | 101029 | 0 | None | -120 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 399 | 7 | 1 | 4 | 4.6 | c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm981133m | ||
| CHEMBL294547 | 101029 | 0 | None | -120 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 399 | 7 | 1 | 4 | 4.6 | c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm981133m | ||
| 4806 | 4008 | 88 | None | 1 | 3 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | ||
| 7351 | 4008 | 88 | None | 1 | 3 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | ||
| 9966051 | 4008 | 88 | None | 1 | 3 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | ||
| CHEMBL2104993 | 4008 | 88 | None | 1 | 3 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | ||
| DB09068 | 4008 | 88 | None | 1 | 3 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | ||
| 11796806 | 102717 | 0 | None | -169 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 428 | 8 | 1 | 5 | 4.3 | CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | ||
| CHEMBL304857 | 102717 | 0 | None | -169 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 428 | 8 | 1 | 5 | 4.3 | CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | ||
| 2869 | 4152 | 89 | None | -3 | 5 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1016/s0960-894x(98)00090-0 | ||
| 60 | 4152 | 89 | None | -3 | 5 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1016/s0960-894x(98)00090-0 | ||
| 60857 | 4152 | 89 | None | -3 | 5 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1016/s0960-894x(98)00090-0 | ||
| CHEMBL1185 | 4152 | 89 | None | -3 | 5 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1016/s0960-894x(98)00090-0 | ||
| DB00315 | 4152 | 89 | None | -3 | 5 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1016/s0960-894x(98)00090-0 | ||
| 44592371 | 178994 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 416 | 5 | 1 | 5 | 3.6 | Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| CHEMBL470849 | 178994 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 416 | 5 | 1 | 5 | 3.6 | Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| 10766570 | 203380 | 0 | None | -501 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 464 | 8 | 1 | 5 | 4.2 | CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1cccc(F)c1 | 10.1021/jm981133m | ||
| CHEMBL65321 | 203380 | 0 | None | -501 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 464 | 8 | 1 | 5 | 4.2 | CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1cccc(F)c1 | 10.1021/jm981133m | ||
| 10600213 | 203109 | 0 | None | -575 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 464 | 8 | 1 | 5 | 4.2 | CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1 | 10.1021/jm981133m | ||
| CHEMBL64004 | 203109 | 0 | None | -575 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 464 | 8 | 1 | 5 | 4.2 | CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1 | 10.1021/jm981133m | ||
| 145975946 | 163920 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 307 | 8 | 1 | 4 | 3.9 | CCCCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1 | 10.1021/acs.jnatprod.7b00317 | ||
| CHEMBL4207355 | 163920 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 307 | 8 | 1 | 4 | 3.9 | CCCCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1 | 10.1021/acs.jnatprod.7b00317 | ||
| 24762221 | 19319 | 0 | None | -39 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 414 | 4 | 1 | 4 | 4.1 | Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4CCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| CHEMBL1290596 | 19319 | 0 | None | -39 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 414 | 4 | 1 | 4 | 4.1 | Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4CCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| 11797999 | 40525 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3ccccc3COc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | ||
| CHEMBL148314 | 40525 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3ccccc3COc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | ||
| 10385855 | 14425 | 0 | None | -3 | 3 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 392 | 6 | 2 | 4 | 2.7 | Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1 | 10.1016/S0960-894X(97)10164-0 | ||
| CHEMBL120055 | 14425 | 0 | None | -3 | 3 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 392 | 6 | 2 | 4 | 2.7 | Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1 | 10.1016/S0960-894X(97)10164-0 | ||
| CHEMBL321818 | 14425 | 0 | None | -3 | 3 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 392 | 6 | 2 | 4 | 2.7 | Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1 | 10.1016/S0960-894X(97)10164-0 | ||
| 10791125 | 18961 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 486 | 5 | 0 | 5 | 4.2 | Cc1cc(C)c(N2CCN(C(=O)COc3ccc4cccc(N5CCN(C)CC5)c4c3)CC2)c(C)c1 | 10.1021/jm9703552 | ||
| CHEMBL128699 | 18961 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 486 | 5 | 0 | 5 | 4.2 | Cc1cc(C)c(N2CCN(C(=O)COc3ccc4cccc(N5CCN(C)CC5)c4c3)CC2)c(C)c1 | 10.1021/jm9703552 | ||
| 10649124 | 19470 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 502 | 5 | 0 | 7 | 3.1 | CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(c5cccc6c5OCCO6)CC4)cc23)CC1 | 10.1021/jm9703552 | ||
| CHEMBL129813 | 19470 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 502 | 5 | 0 | 7 | 3.1 | CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(c5cccc6c5OCCO6)CC4)cc23)CC1 | 10.1021/jm9703552 | ||
| 44592333 | 178838 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 444 | 5 | 0 | 5 | 4.0 | Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| CHEMBL469376 | 178838 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 444 | 5 | 0 | 5 | 4.0 | Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| 1220 | 187 | 55 | None | -109 | 9 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1016/s0960-894x(98)00222-4 | ||
| 31 | 187 | 55 | None | -109 | 9 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1016/s0960-894x(98)00222-4 | ||
| 7 | 187 | 55 | None | -109 | 9 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1016/s0960-894x(98)00222-4 | ||
| CHEMBL56 | 187 | 55 | None | -109 | 9 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1016/s0960-894x(98)00222-4 | ||
| 10838063 | 78776 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 469 | 5 | 0 | 6 | 3.2 | CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(c5ccccc5C#N)CC4)cc23)CC1 | 10.1021/jm9703552 | ||
| CHEMBL2112660 | 78776 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 469 | 5 | 0 | 6 | 3.2 | CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(c5ccccc5C#N)CC4)cc23)CC1 | 10.1021/jm9703552 | ||
| 145964150 | 164306 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 279 | 6 | 1 | 4 | 3.1 | CCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1 | 10.1021/acs.jnatprod.7b00317 | ||
| CHEMBL4212246 | 164306 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 279 | 6 | 1 | 4 | 3.1 | CCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1 | 10.1021/acs.jnatprod.7b00317 | ||
| 10719687 | 202999 | 0 | None | -257 | 2 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 485 | 7 | 1 | 4 | 5.7 | FC1(Cc2ccccc2C(F)(F)F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | ||
| CHEMBL63167 | 202999 | 0 | None | -257 | 2 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 485 | 7 | 1 | 4 | 5.7 | FC1(Cc2ccccc2C(F)(F)F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | ||
| 11797998 | 35692 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3ccc(COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12 | 10.1021/jm960552l | ||
| CHEMBL144030 | 35692 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3ccc(COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12 | 10.1021/jm960552l | ||
| 10601619 | 116836 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 504 | 7 | 0 | 7 | 3.3 | COc1cccc(N2CCN(C(=O)COc3ccc4cccc(N5CCN(C)CC5)c4c3)CC2)c1OC | 10.1021/jm9703552 | ||
| CHEMBL338015 | 116836 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 504 | 7 | 0 | 7 | 3.3 | COc1cccc(N2CCN(C(=O)COc3ccc4cccc(N5CCN(C)CC5)c4c3)CC2)c1OC | 10.1021/jm9703552 | ||
| 52946290 | 19102 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 446 | 4 | 0 | 5 | 4.4 | Cc1ccc2c(N3CCN(CCc4c(Cl)ccc5c4ccc(=O)n5C)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| CHEMBL1289164 | 19102 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 446 | 4 | 0 | 5 | 4.4 | Cc1ccc2c(N3CCN(CCc4c(Cl)ccc5c4ccc(=O)n5C)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| 2543 | 3707 | 68 | None | 2 | 14 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(98)00090-0 | ||
| 5358 | 3707 | 68 | None | 2 | 14 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(98)00090-0 | ||
| 54 | 3707 | 68 | None | 2 | 14 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(98)00090-0 | ||
| CHEMBL128 | 3707 | 68 | None | 2 | 14 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(98)00090-0 | ||
| DB00669 | 3707 | 68 | None | 2 | 14 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(98)00090-0 | ||
| 24804774 | 19320 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 428 | 4 | 0 | 4 | 4.1 | Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4CCC(=O)N5C)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| CHEMBL1290597 | 19320 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 428 | 4 | 0 | 4 | 4.1 | Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4CCC(=O)N5C)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| 10809674 | 119196 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 378 | 9 | 4 | 4 | 3.1 | NCCc1c[nH]c2ccc(OCCOc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | ||
| CHEMBL343196 | 119196 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 378 | 9 | 4 | 4 | 3.1 | NCCc1c[nH]c2ccc(OCCOc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | ||
| 5 | 139 | 72 | None | -19 | 26 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(98)00222-4 | ||
| 5202 | 139 | 72 | None | -19 | 26 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(98)00222-4 | ||
| CHEMBL39 | 139 | 72 | None | -19 | 26 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(98)00222-4 | ||
| DB08839 | 139 | 72 | None | -19 | 26 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(98)00222-4 | ||
| 5 | 139 | 72 | None | -19 | 26 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm960552l | ||
| 5202 | 139 | 72 | None | -19 | 26 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm960552l | ||
| CHEMBL39 | 139 | 72 | None | -19 | 26 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm960552l | ||
| DB08839 | 139 | 72 | None | -19 | 26 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm960552l | ||
| 114 | 2254 | 14 | None | -169 | 6 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm981133m | ||
| 6426760 | 2254 | 14 | None | -169 | 6 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm981133m | ||
| CHEMBL292779 | 2254 | 14 | None | -169 | 6 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm981133m | ||
| 10503687 | 203077 | 0 | None | -50 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 449 | 8 | 1 | 4 | 5.3 | Fc1cccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | ||
| CHEMBL63799 | 203077 | 0 | None | -50 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 449 | 8 | 1 | 4 | 5.3 | Fc1cccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | ||
| 10341917 | 168049 | 0 | None | -97 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 417 | 7 | 1 | 4 | 4.6 | FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm981133m | ||
| CHEMBL432332 | 168049 | 0 | None | -97 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 417 | 7 | 1 | 4 | 4.6 | FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm981133m | ||
| 10076876 | 101712 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 576 | 19 | 0 | 4 | 8.7 | CCCN(CCC)C1CCc2cccc(OCCCCCCOc3cccc4c3CC(N(CCC)CCC)CC4)c2C1 | 10.1016/s0960-894x(98)00222-4 | ||
| CHEMBL29951 | 101712 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 576 | 19 | 0 | 4 | 8.7 | CCCN(CCC)C1CCc2cccc(OCCCCCCOc3cccc4c3CC(N(CCC)CCC)CC4)c2C1 | 10.1016/s0960-894x(98)00222-4 | ||
| 52943811 | 19082 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 412 | 4 | 1 | 4 | 4.1 | Cc1ccc2c(N3CCN(CCc4c(C)ccc5[nH]c(=O)ccc45)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| CHEMBL1289047 | 19082 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 412 | 4 | 1 | 4 | 4.1 | Cc1ccc2c(N3CCN(CCc4c(C)ccc5[nH]c(=O)ccc45)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| 10551328 | 203721 | 0 | None | -97 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 445 | 8 | 1 | 4 | 5.7 | CC(CC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm981133m | ||
| CHEMBL67684 | 203721 | 0 | None | -97 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 445 | 8 | 1 | 4 | 5.7 | CC(CC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm981133m | ||
| 10837853 | 168158 | 0 | None | -309 | 2 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 464 | 8 | 1 | 5 | 4.3 | CC(CN1CCN(CC(F)(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm981133m | ||
| CHEMBL433108 | 168158 | 0 | None | -309 | 2 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 464 | 8 | 1 | 5 | 4.3 | CC(CN1CCN(CC(F)(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm981133m | ||
| 11 | 1187 | 19 | None | 75 | 4 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 215 | 1 | 3 | 2 | 1.2 | O=c1ccc2c([nH]1)c(c[nH]2)C1=CCNCC1 | 10.1021/jm00170a007 | ||
| 124007 | 1187 | 19 | None | 75 | 4 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 215 | 1 | 3 | 2 | 1.2 | O=c1ccc2c([nH]1)c(c[nH]2)C1=CCNCC1 | 10.1021/jm00170a007 | ||
| CHEMBL304008 | 1187 | 19 | None | 75 | 4 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 215 | 1 | 3 | 2 | 1.2 | O=c1ccc2c([nH]1)c(c[nH]2)C1=CCNCC1 | 10.1021/jm00170a007 | ||
| 44592208 | 179179 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 416 | 4 | 0 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)OCC(=O)N5C)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| CHEMBL472289 | 179179 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 416 | 4 | 0 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)OCC(=O)N5C)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| 52948697 | 19083 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 426 | 4 | 0 | 5 | 4.1 | Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4ccc(=O)n5C)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| CHEMBL1289048 | 19083 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 426 | 4 | 0 | 5 | 4.1 | Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4ccc(=O)n5C)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| 44592332 | 178837 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 430 | 5 | 0 | 5 | 3.7 | Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| CHEMBL469375 | 178837 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 430 | 5 | 0 | 5 | 3.7 | Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| 9844873 | 101058 | 0 | None | -48 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 417 | 7 | 1 | 4 | 4.7 | FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | ||
| CHEMBL294732 | 101058 | 0 | None | -48 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 417 | 7 | 1 | 4 | 4.7 | FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | ||
| 2543 | 3707 | 68 | None | 2 | 14 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm960552l | ||
| 5358 | 3707 | 68 | None | 2 | 14 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm960552l | ||
| 54 | 3707 | 68 | None | 2 | 14 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm960552l | ||
| CHEMBL128 | 3707 | 68 | None | 2 | 14 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm960552l | ||
| DB00669 | 3707 | 68 | None | 2 | 14 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm960552l | ||
| 10575553 | 203039 | 0 | None | -245 | 2 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 450 | 8 | 1 | 5 | 3.6 | Fc1cccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | ||
| CHEMBL63432 | 203039 | 0 | None | -245 | 2 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 450 | 8 | 1 | 5 | 3.6 | Fc1cccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | ||
| 10621021 | 203384 | 0 | None | -66 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 400 | 7 | 1 | 5 | 3.5 | c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/acs.jmedchem.7b01788 | ||
| CHEMBL65367 | 203384 | 0 | None | -66 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 400 | 7 | 1 | 5 | 3.5 | c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/acs.jmedchem.7b01788 | ||
| 9844873 | 101058 | 0 | None | -48 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 417 | 7 | 1 | 4 | 4.7 | FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/acs.jmedchem.7b01788 | ||
| CHEMBL294732 | 101058 | 0 | None | -48 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 417 | 7 | 1 | 4 | 4.7 | FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/acs.jmedchem.7b01788 | ||
| 18975369 | 101029 | 0 | None | -120 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 399 | 7 | 1 | 4 | 4.6 | c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/acs.jmedchem.7b01788 | ||
| CHEMBL294547 | 101029 | 0 | None | -120 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 399 | 7 | 1 | 4 | 4.6 | c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/acs.jmedchem.7b01788 | ||
| 145975946 | 163920 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 307 | 8 | 1 | 4 | 3.9 | CCCCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1 | 10.1021/acs.jnatprod.7b00317 | ||
| CHEMBL4207355 | 163920 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 307 | 8 | 1 | 4 | 3.9 | CCCCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1 | 10.1021/acs.jnatprod.7b00317 | ||
| 145964150 | 164306 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 279 | 6 | 1 | 4 | 3.1 | CCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1 | 10.1021/acs.jnatprod.7b00317 | ||
| CHEMBL4212246 | 164306 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 279 | 6 | 1 | 4 | 3.1 | CCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1 | 10.1021/acs.jnatprod.7b00317 | ||
| 146395245 | 189057 | 15 | None | 4 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 400 | 3 | 2 | 3 | 2.8 | CC(=O)N1CCN([C@H]2CCC[C@@H](NC(=O)c3cc4c(F)ccc(C)c4[nH]3)C2)CC1 | 10.1021/acsmedchemlett.2c00167 | ||
| CHEMBL5095235 | 189057 | 15 | None | 4 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 400 | 3 | 2 | 3 | 2.8 | CC(=O)N1CCN([C@H]2CCC[C@@H](NC(=O)c3cc4c(F)ccc(C)c4[nH]3)C2)CC1 | 10.1021/acsmedchemlett.2c00167 | ||
| 11568826 | 132798 | 0 | None | 9 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5cncc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL370110 | 132798 | 0 | None | 9 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5cncc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| 11662592 | 72344 | 0 | None | 15 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccnc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL198463 | 72344 | 0 | None | 15 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccnc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| 11655728 | 16644 | 8 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 468 | 5 | 1 | 7 | 3.1 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| CHEMBL1241913 | 16644 | 8 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 468 | 5 | 1 | 7 | 3.1 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| 10447834 | 1933 | 4 | None | - | 3 | Human | 4.9 | pKd | = | 4.9 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 4026 | 1933 | 4 | None | - | 3 | Human | 4.9 | pKd | = | 4.9 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| CHEMBL275507 | 1933 | 4 | None | - | 3 | Human | 4.9 | pKd | = | 4.9 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 44373817 | 11718 | 0 | None | - | 0 | Human | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 298 | 2 | 1 | 3 | 3.2 | CC(C)n1cc2c3c(cccc31)[C@H]1C[C@@H](CO)CN(C)[C@@H]1C2 | 10.1021/jm981092u | ||
| CHEMBL1181270 | 11718 | 0 | None | - | 0 | Human | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 298 | 2 | 1 | 3 | 3.2 | CC(C)n1cc2c3c(cccc31)[C@H]1C[C@@H](CO)CN(C)[C@@H]1C2 | 10.1021/jm981092u | ||
| CHEMBL161046 | 11718 | 0 | None | - | 0 | Human | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 298 | 2 | 1 | 3 | 3.2 | CC(C)n1cc2c3c(cccc31)[C@H]1C[C@@H](CO)CN(C)[C@@H]1C2 | 10.1021/jm981092u | ||
| 44373789 | 11721 | 0 | None | - | 0 | Human | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 296 | 2 | 1 | 3 | 3.1 | CC(C)n1cc2c3c(cccc31)C1=C[C@@H](CO)CN(C)[C@@H]1C2 | 10.1021/jm981092u | ||
| CHEMBL1181275 | 11721 | 0 | None | - | 0 | Human | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 296 | 2 | 1 | 3 | 3.1 | CC(C)n1cc2c3c(cccc31)C1=C[C@@H](CO)CN(C)[C@@H]1C2 | 10.1021/jm981092u | ||
| CHEMBL161368 | 11721 | 0 | None | - | 0 | Human | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 296 | 2 | 1 | 3 | 3.1 | CC(C)n1cc2c3c(cccc31)C1=C[C@@H](CO)CN(C)[C@@H]1C2 | 10.1021/jm981092u | ||
| 10403687 | 2511 | 3 | None | - | 2 | Human | 5.1 | pKd | = | 5.1 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 1205 | 2511 | 3 | None | - | 2 | Human | 5.1 | pKd | = | 5.1 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| CHEMBL275035 | 2511 | 3 | None | - | 2 | Human | 5.1 | pKd | = | 5.1 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 44373791 | 12233 | 0 | None | - | 0 | Human | 6.1 | pKd | = | 6.1 | Functional | ChEMBL | 296 | 2 | 1 | 3 | 3.1 | CC(C)n1cc2c3c(cccc31)[C@H]1C=C(CO)CN(C)[C@@H]1C2 | 10.1021/jm981092u | ||
| CHEMBL1184450 | 12233 | 0 | None | - | 0 | Human | 6.1 | pKd | = | 6.1 | Functional | ChEMBL | 296 | 2 | 1 | 3 | 3.1 | CC(C)n1cc2c3c(cccc31)[C@H]1C=C(CO)CN(C)[C@@H]1C2 | 10.1021/jm981092u | ||
| CHEMBL349405 | 12233 | 0 | None | - | 0 | Human | 6.1 | pKd | = | 6.1 | Functional | ChEMBL | 296 | 2 | 1 | 3 | 3.1 | CC(C)n1cc2c3c(cccc31)[C@H]1C=C(CO)CN(C)[C@@H]1C2 | 10.1021/jm981092u | ||
| 11797998 | 35692 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Functional | ChEMBL | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3ccc(COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12 | 10.1021/jm960552l | ||
| CHEMBL144030 | 35692 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Functional | ChEMBL | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3ccc(COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12 | 10.1021/jm960552l | ||
| 44405730 | 168919 | 0 | None | - | 0 | Human | 10.0 | pKi | = | 10 | Functional | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6ccncc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL438619 | 168919 | 0 | None | - | 0 | Human | 10.0 | pKi | = | 10 | Functional | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6ccncc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| 10720301 | 39984 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10.0 | Functional | ChEMBL | 504 | 11 | 4 | 6 | 2.3 | NCCc1c[nH]c2ccc(OCCN3CCN(C(=O)COc4ccc5[nH]cc(CCN)c5c4)CC3)cc12 | 10.1021/jm960552l | ||
| CHEMBL147851 | 39984 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10.0 | Functional | ChEMBL | 504 | 11 | 4 | 6 | 2.3 | NCCc1c[nH]c2ccc(OCCN3CCN(C(=O)COc4ccc5[nH]cc(CCN)c5c4)CC3)cc12 | 10.1021/jm960552l | ||
| 10008868 | 121125 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Functional | ChEMBL | 609 | 12 | 5 | 7 | 3.4 | NCCc1c[nH]c2ccc(OCC(=O)Nc3ccc(N4CCN(C(=O)COc5ccc6[nH]cc(CCN)c6c5)CC4)cc3)cc12 | 10.1021/jm960552l | ||
| CHEMBL357478 | 121125 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Functional | ChEMBL | 609 | 12 | 5 | 7 | 3.4 | NCCc1c[nH]c2ccc(OCC(=O)Nc3ccc(N4CCN(C(=O)COc5ccc6[nH]cc(CCN)c6c5)CC4)cc3)cc12 | 10.1021/jm960552l | ||
| 11797158 | 40040 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Functional | ChEMBL | 435 | 11 | 5 | 5 | 2.2 | NCCc1c[nH]c2ccc(OCCNC(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | ||
| CHEMBL147901 | 40040 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Functional | ChEMBL | 435 | 11 | 5 | 5 | 2.2 | NCCc1c[nH]c2ccc(OCCNC(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | ||
| 10837858 | 39806 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Functional | ChEMBL | 464 | 12 | 6 | 5 | 2.4 | NCCc1c[nH]c2ccc(OCCNC(=O)NCCOc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | ||
| CHEMBL147677 | 39806 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Functional | ChEMBL | 464 | 12 | 6 | 5 | 2.4 | NCCc1c[nH]c2ccc(OCCNC(=O)NCCOc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | ||
| 10531639 | 121272 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Functional | ChEMBL | 600 | 11 | 4 | 6 | 3.6 | NCCc1c[nH]c2ccc(OCC(=O)N3CCC(C4CCN(C(=O)COc5ccc6[nH]cc(CCN)c6c5)CC4)CC3)cc12 | 10.1021/jm960552l | ||
| CHEMBL357830 | 121272 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Functional | ChEMBL | 600 | 11 | 4 | 6 | 3.6 | NCCc1c[nH]c2ccc(OCC(=O)N3CCC(C4CCN(C(=O)COc5ccc6[nH]cc(CCN)c6c5)CC4)CC3)cc12 | 10.1021/jm960552l | ||
| 10791244 | 35797 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Functional | ChEMBL | 490 | 12 | 4 | 6 | 2.7 | NCCc1c[nH]c2ccc(OCCN3CCN(CCOc4ccc5[nH]cc(CCN)c5c4)CC3)cc12 | 10.1021/jm960552l | ||
| CHEMBL144128 | 35797 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Functional | ChEMBL | 490 | 12 | 4 | 6 | 2.7 | NCCc1c[nH]c2ccc(OCCN3CCN(CCOc4ccc5[nH]cc(CCN)c5c4)CC3)cc12 | 10.1021/jm960552l | ||
| 11800592 | 120985 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Functional | ChEMBL | 540 | 12 | 6 | 6 | 3.7 | NCCc1c[nH]c2ccc(OCC(=O)Nc3ccc(NC(=O)COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12 | 10.1021/jm960552l | ||
| CHEMBL356277 | 120985 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Functional | ChEMBL | 540 | 12 | 6 | 6 | 3.7 | NCCc1c[nH]c2ccc(OCC(=O)Nc3ccc(NC(=O)COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12 | 10.1021/jm960552l | ||
| 10696930 | 36088 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 506 | 14 | 6 | 6 | 1.7 | NCCc1c[nH]c2ccc(OCC(=O)NCCCNC(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | ||
| CHEMBL144397 | 36088 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 506 | 14 | 6 | 6 | 1.7 | NCCc1c[nH]c2ccc(OCC(=O)NCCCNC(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | ||
| 9868889 | 72629 | 0 | None | - | 0 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6cccnc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL199443 | 72629 | 0 | None | - | 0 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6cccnc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| 10647387 | 40191 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3cccc(COc4ccc5[nH]cc(CCN)c5c4)c3)cc12 | 10.1021/jm960552l | ||
| CHEMBL148022 | 40191 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3cccc(COc4ccc5[nH]cc(CCN)c5c4)c3)cc12 | 10.1021/jm960552l | ||
| 9984109 | 38877 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Functional | ChEMBL | 518 | 10 | 4 | 6 | 1.8 | NCCc1c[nH]c2ccc(OCC(=O)N3CCN(C(=O)COc4ccc5[nH]cc(CCN)c5c4)CC3)cc12 | 10.1021/jm960552l | ||
| CHEMBL146720 | 38877 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Functional | ChEMBL | 518 | 10 | 4 | 6 | 1.8 | NCCc1c[nH]c2ccc(OCC(=O)N3CCN(C(=O)COc4ccc5[nH]cc(CCN)c5c4)CC3)cc12 | 10.1021/jm960552l | ||
| 9897637 | 118932 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Functional | ChEMBL | 828 | 25 | 6 | 8 | 7.2 | NCCc1c[nH]c2ccc(OCCCCCCNS(=O)(=O)c3ccc(-c4ccc(S(=O)(=O)NCCCCCCOc5ccc6[nH]cc(CCN)c6c5)cc4)cc3)cc12 | 10.1021/jm960552l | ||
| CHEMBL342323 | 118932 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Functional | ChEMBL | 828 | 25 | 6 | 8 | 7.2 | NCCc1c[nH]c2ccc(OCCCCCCNS(=O)(=O)c3ccc(-c4ccc(S(=O)(=O)NCCCCCCOc5ccc6[nH]cc(CCN)c6c5)cc4)cc3)cc12 | 10.1021/jm960552l | ||
| 44405669 | 71971 | 0 | None | - | 0 | Human | 9.4 | pKi | = | 9.4 | Functional | ChEMBL | 465 | 4 | 0 | 8 | 3.5 | CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6ccsc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL197344 | 71971 | 0 | None | - | 0 | Human | 9.4 | pKi | = | 9.4 | Functional | ChEMBL | 465 | 4 | 0 | 8 | 3.5 | CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6ccsc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| 10836606 | 165533 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 434 | 13 | 4 | 4 | 4.7 | NCCc1c[nH]c2ccc(OCCCCCCOc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | ||
| CHEMBL424128 | 165533 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 434 | 13 | 4 | 4 | 4.7 | NCCc1c[nH]c2ccc(OCCCCCCOc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | ||
| 44405725 | 71835 | 0 | None | - | 0 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 473 | 5 | 0 | 8 | 2.9 | COc1c(Cl)cccc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL196914 | 71835 | 0 | None | - | 0 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 473 | 5 | 0 | 8 | 2.9 | COc1c(Cl)cccc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | ||
| 22464649 | 72449 | 0 | None | - | 0 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 459 | 4 | 0 | 7 | 3.4 | CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL198836 | 72449 | 0 | None | - | 0 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 459 | 4 | 0 | 7 | 3.4 | CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| 44405666 | 72873 | 0 | None | - | 0 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 451 | 4 | 0 | 8 | 2.2 | CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6c5OCC6)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL200315 | 72873 | 0 | None | - | 0 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 451 | 4 | 0 | 8 | 2.2 | CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6c5OCC6)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| 9933975 | 133587 | 0 | None | - | 0 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5nccc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL371221 | 133587 | 0 | None | - | 0 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5nccc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| 46900954 | 16652 | 0 | None | - | 0 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 508 | 6 | 1 | 7 | 3.9 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC6CC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| CHEMBL1242081 | 16652 | 0 | None | - | 0 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 508 | 6 | 1 | 7 | 3.9 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC6CC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| 46900776 | 16639 | 0 | None | - | 0 | Human | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 496 | 5 | 0 | 7 | 3.7 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N(C)C)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| CHEMBL1241824 | 16639 | 0 | None | - | 0 | Human | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 496 | 5 | 0 | 7 | 3.7 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N(C)C)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| 46900956 | 16654 | 0 | None | - | 0 | Human | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 522 | 6 | 1 | 7 | 4.3 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC6CCC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| CHEMBL1242167 | 16654 | 0 | None | - | 0 | Human | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 522 | 6 | 1 | 7 | 4.3 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC6CCC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| 52942551 | 19300 | 0 | None | - | 0 | Human | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 400 | 4 | 1 | 4 | 3.8 | Cc1ccc2c(N3CCN(CCc4cccc5c4CCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| CHEMBL1290486 | 19300 | 0 | None | - | 0 | Human | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 400 | 4 | 1 | 4 | 3.8 | Cc1ccc2c(N3CCN(CCc4cccc5c4CCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| 46900459 | 16638 | 0 | None | - | 0 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 440 | 4 | 0 | 7 | 3.7 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nnc(C)n4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| CHEMBL1241738 | 16638 | 0 | None | - | 0 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 440 | 4 | 0 | 7 | 3.7 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nnc(C)n4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| 52947615 | 19136 | 0 | None | - | 0 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 444 | 4 | 0 | 5 | 4.3 | Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)[C@H](C)C3)cc(F)cc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| CHEMBL1289394 | 19136 | 0 | None | - | 0 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 444 | 4 | 0 | 5 | 4.3 | Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)[C@H](C)C3)cc(F)cc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| 52947414 | 19301 | 0 | None | - | 0 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 414 | 4 | 0 | 4 | 3.8 | Cc1ccc2c(N3CCN(CCc4cccc5c4CCC(=O)N5C)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| CHEMBL1290487 | 19301 | 0 | None | - | 0 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 414 | 4 | 0 | 4 | 3.8 | Cc1ccc2c(N3CCN(CCc4cccc5c4CCC(=O)N5C)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| 24804775 | 19343 | 0 | None | - | 2 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 412 | 4 | 0 | 5 | 3.8 | Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| CHEMBL1290716 | 19343 | 0 | None | - | 2 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 412 | 4 | 0 | 5 | 3.8 | Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| 44405702 | 72580 | 0 | None | - | 0 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6cnccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL199269 | 72580 | 0 | None | - | 0 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6cnccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| 46900455 | 16633 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 493 | 4 | 0 | 6 | 5.0 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nc(C(F)(F)F)cn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| CHEMBL1241641 | 16633 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 493 | 4 | 0 | 6 | 5.0 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nc(C(F)(F)F)cn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| 46900457 | 16634 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 425 | 4 | 0 | 6 | 4.0 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4cncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| CHEMBL1241642 | 16634 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 425 | 4 | 0 | 6 | 4.0 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4cncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| 46900612 | 16636 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 467 | 5 | 0 | 7 | 4.2 | CC(=O)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2 | 10.1021/jm100482n | ||
| CHEMBL1241736 | 16636 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 467 | 5 | 0 | 7 | 4.2 | CC(=O)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2 | 10.1021/jm100482n | ||
| 46899639 | 16669 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 522 | 5 | 0 | 7 | 4.2 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCCC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| CHEMBL1242533 | 16669 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 522 | 5 | 0 | 7 | 4.2 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCCC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| 11720815 | 16684 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 538 | 5 | 0 | 8 | 3.5 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCOCC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| CHEMBL1242717 | 16684 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 538 | 5 | 0 | 8 | 3.5 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCOCC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| 44138098 | 189472 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| CHEMBL513715 | 189472 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| 44138098 | 189472 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| CHEMBL513715 | 189472 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| 44138098 | 189472 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| CHEMBL513715 | 189472 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| 44405573 | 71857 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9.0 | Functional | ChEMBL | 485 | 5 | 0 | 7 | 3.9 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccccc5-c5ccccc5)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL197007 | 71857 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9.0 | Functional | ChEMBL | 485 | 5 | 0 | 7 | 3.9 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccccc5-c5ccccc5)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| 44405574 | 72435 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9.0 | Functional | ChEMBL | 501 | 6 | 0 | 8 | 4.1 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccccc5Oc5ccccc5)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL198792 | 72435 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9.0 | Functional | ChEMBL | 501 | 6 | 0 | 8 | 4.1 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccccc5Oc5ccccc5)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| 44405575 | 72494 | 0 | None | - | 0 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 515 | 7 | 0 | 8 | 3.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccccc5OCc5ccccc5)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL198999 | 72494 | 0 | None | - | 0 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 515 | 7 | 0 | 8 | 3.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccccc5OCc5ccccc5)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| 46900610 | 16632 | 0 | None | - | 0 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 497 | 6 | 0 | 8 | 4.2 | CCOC(=O)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2 | 10.1021/jm100482n | ||
| CHEMBL1241640 | 16632 | 0 | None | - | 0 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 497 | 6 | 0 | 8 | 4.2 | CCOC(=O)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2 | 10.1021/jm100482n | ||
| 11712756 | 16643 | 0 | None | - | 0 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 482 | 5 | 1 | 7 | 3.3 | CNC(=O)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2 | 10.1021/jm100482n | ||
| CHEMBL1241912 | 16643 | 0 | None | - | 0 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 482 | 5 | 1 | 7 | 3.3 | CNC(=O)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2 | 10.1021/jm100482n | ||
| 22464842 | 71817 | 0 | None | - | 0 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 434 | 4 | 0 | 8 | 2.1 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccccc5C#N)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL196862 | 71817 | 0 | None | - | 0 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 434 | 4 | 0 | 8 | 2.1 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccccc5C#N)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| 9872238 | 72514 | 0 | None | - | 0 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 439 | 5 | 0 | 8 | 2.3 | COc1ccccc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL199049 | 72514 | 0 | None | - | 0 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 439 | 5 | 0 | 8 | 2.3 | COc1ccccc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | ||
| 46900451 | 16626 | 0 | None | - | 0 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 439 | 4 | 0 | 6 | 4.3 | Cc1cn2c(n1)COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2 | 10.1021/jm100482n | ||
| CHEMBL1241547 | 16626 | 0 | None | - | 0 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 439 | 4 | 0 | 6 | 4.3 | Cc1cn2c(n1)COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2 | 10.1021/jm100482n | ||
| 46900778 | 16640 | 0 | None | - | 0 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 450 | 4 | 0 | 7 | 3.9 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C#N)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| CHEMBL1241825 | 16640 | 0 | None | - | 0 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 450 | 4 | 0 | 7 | 3.9 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C#N)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| 11655728 | 16644 | 8 | None | - | 0 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 468 | 5 | 1 | 7 | 3.1 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| CHEMBL1241913 | 16644 | 8 | None | - | 0 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 468 | 5 | 1 | 7 | 3.1 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| 46899637 | 16660 | 0 | None | - | 0 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 522 | 7 | 1 | 7 | 4.1 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NCC6CC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| CHEMBL1242345 | 16660 | 0 | None | - | 0 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 522 | 7 | 1 | 7 | 4.1 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NCC6CC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| 46899638 | 16664 | 0 | None | - | 0 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 508 | 5 | 0 | 7 | 3.8 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| CHEMBL1242436 | 16664 | 0 | None | - | 0 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 508 | 5 | 0 | 7 | 3.8 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| 46899640 | 16676 | 0 | None | - | 0 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 536 | 5 | 0 | 7 | 4.6 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCCCC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| CHEMBL1242623 | 16676 | 0 | None | - | 0 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 536 | 5 | 0 | 7 | 4.6 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCCCC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| 46900150 | 16696 | 0 | None | - | 0 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 425 | 4 | 0 | 6 | 4.0 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nccn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| CHEMBL1242904 | 16696 | 0 | None | - | 0 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 425 | 4 | 0 | 6 | 4.0 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nccn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| 44138104 | 178833 | 0 | None | - | 0 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 416 | 4 | 0 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| CHEMBL469345 | 178833 | 0 | None | - | 0 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 416 | 4 | 0 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| 11797999 | 40525 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3ccccc3COc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | ||
| CHEMBL148314 | 40525 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3ccccc3COc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | ||
| 44405701 | 71931 | 0 | None | - | 0 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6ncccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL197240 | 71931 | 0 | None | - | 0 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6ncccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| 22464720 | 72401 | 0 | None | - | 0 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 443 | 4 | 0 | 7 | 2.9 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccccc5Cl)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL198696 | 72401 | 0 | None | - | 0 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 443 | 4 | 0 | 7 | 2.9 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccccc5Cl)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| 46900453 | 16627 | 0 | None | - | 0 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 453 | 4 | 0 | 6 | 4.6 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nc(C)c(C)n4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| CHEMBL1241548 | 16627 | 0 | None | - | 0 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 453 | 4 | 0 | 6 | 4.6 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nc(C)c(C)n4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| 46900958 | 16659 | 0 | None | - | 0 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 536 | 6 | 1 | 7 | 4.7 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC6CCCC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| CHEMBL1242257 | 16659 | 0 | None | - | 0 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 536 | 6 | 1 | 7 | 4.7 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC6CCCC6)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| 9979309 | 192982 | 0 | None | - | 0 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 416 | 4 | 0 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| CHEMBL522257 | 192982 | 0 | None | - | 0 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 416 | 4 | 0 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| 52942644 | 19342 | 0 | None | - | 0 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 398 | 4 | 1 | 4 | 3.7 | Cc1ccc2c(N3CCN(CCc4cccc5[nH]c(=O)ccc45)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| CHEMBL1290715 | 19342 | 0 | None | - | 0 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 398 | 4 | 1 | 4 | 3.7 | Cc1ccc2c(N3CCN(CCc4cccc5[nH]c(=O)ccc45)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| 44592297 | 189490 | 0 | None | - | 0 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 448 | 4 | 0 | 5 | 3.8 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cc(F)cc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| CHEMBL513875 | 189490 | 0 | None | - | 0 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 448 | 4 | 0 | 5 | 3.8 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cc(F)cc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| 9979309 | 192982 | 0 | None | - | 0 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 416 | 4 | 0 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| CHEMBL522257 | 192982 | 0 | None | - | 0 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 416 | 4 | 0 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| 14519851 | 116748 | 39 | None | - | 0 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 187 | 3 | 1 | 2 | 2.2 | NCCOc1cccc2ccccc12 | 10.1021/jm970507t | ||
| CHEMBL337539 | 116748 | 39 | None | - | 0 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 187 | 3 | 1 | 2 | 2.2 | NCCOc1cccc2ccccc12 | 10.1021/jm970507t | ||
| 2261792 | 116447 | 6 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 231 | 6 | 2 | 3 | 1.8 | OCCNCCOc1cccc2ccccc12 | 10.1021/jm970507t | ||
| CHEMBL336092 | 116447 | 6 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 231 | 6 | 2 | 3 | 1.8 | OCCNCCOc1cccc2ccccc12 | 10.1021/jm970507t | ||
| 44405655 | 71878 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 453 | 5 | 0 | 8 | 2.6 | COc1ccc(C)cc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL197064 | 71878 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 453 | 5 | 0 | 8 | 2.6 | COc1ccc(C)cc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | ||
| 10584924 | 30410 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6.0 | Functional | ChEMBL | 218 | 5 | 2 | 2 | 2.5 | CC(C)NCCOc1cccc2[nH]ccc12 | 10.1021/jm970507t | ||
| CHEMBL139230 | 30410 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6.0 | Functional | ChEMBL | 218 | 5 | 2 | 2 | 2.5 | CC(C)NCCOc1cccc2[nH]ccc12 | 10.1021/jm970507t | ||
| 22464806 | 71844 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 515 | 6 | 0 | 8 | 3.9 | COc1ccc(-c2ccccc2)cc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL196961 | 71844 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 515 | 6 | 0 | 8 | 3.9 | COc1ccc(-c2ccccc2)cc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | ||
| 10775772 | 30107 | 2 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 229 | 5 | 1 | 2 | 3.2 | CC(C)NCCOc1cccc2ccccc12 | 10.1021/jm970507t | ||
| CHEMBL138963 | 30107 | 2 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 229 | 5 | 1 | 2 | 3.2 | CC(C)NCCOc1cccc2ccccc12 | 10.1021/jm970507t | ||
| 10588458 | 27611 | 0 | None | - | 0 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 275 | 8 | 0 | 2 | 4.5 | CCCN(C)CCCOc1ccccc1C1CCCC1 | 10.1021/jm970507t | ||
| CHEMBL136962 | 27611 | 0 | None | - | 0 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 275 | 8 | 0 | 2 | 4.5 | CCCN(C)CCCOc1ccccc1C1CCCC1 | 10.1021/jm970507t | ||
| 6422277 | 30036 | 5 | None | - | 0 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 271 | 8 | 0 | 2 | 4.3 | CCCCN(CC)CCOc1cccc2ccccc12 | 10.1021/jm970507t | ||
| CHEMBL138907 | 30036 | 5 | None | - | 0 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 271 | 8 | 0 | 2 | 4.3 | CCCCN(CC)CCOc1cccc2ccccc12 | 10.1021/jm970507t | ||
| 44592295 | 179009 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 430 | 4 | 0 | 5 | 3.7 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)[C@@H](C)C3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| CHEMBL471047 | 179009 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 430 | 4 | 0 | 5 | 3.7 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)[C@@H](C)C3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| 44592252 | 189194 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 466 | 6 | 0 | 5 | 3.9 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5CC(F)F)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| CHEMBL511279 | 189194 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 466 | 6 | 0 | 5 | 3.9 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5CC(F)F)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| 44592335 | 178925 | 0 | None | - | 0 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 462 | 5 | 0 | 5 | 4.2 | Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cc(F)cc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| CHEMBL470217 | 178925 | 0 | None | - | 0 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 462 | 5 | 0 | 5 | 4.2 | Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cc(F)cc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| 10518850 | 35193 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 308 | 4 | 2 | 4 | 1.9 | NCCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | ||
| CHEMBL143512 | 35193 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 308 | 4 | 2 | 4 | 1.9 | NCCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | ||
| 10809674 | 119196 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 378 | 9 | 4 | 4 | 3.1 | NCCc1c[nH]c2ccc(OCCOc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | ||
| CHEMBL343196 | 119196 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 378 | 9 | 4 | 4 | 3.1 | NCCc1c[nH]c2ccc(OCCOc3ccc4[nH]cc(CCN)c4c3)cc12 | 10.1021/jm960552l | ||
| 44405586 | 71842 | 0 | None | - | 0 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 467 | 6 | 0 | 8 | 3.1 | CC(C)Oc1ccccc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL196958 | 71842 | 0 | None | - | 0 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 467 | 6 | 0 | 8 | 3.1 | CC(C)Oc1ccccc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | ||
| 11568826 | 132798 | 0 | None | 9 | 2 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5cncc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL370110 | 132798 | 0 | None | 9 | 2 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5cncc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| 46900606 | 16625 | 0 | None | - | 0 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 440 | 4 | 0 | 7 | 3.7 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C)nnn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| CHEMBL1241546 | 16625 | 0 | None | - | 0 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 440 | 4 | 0 | 7 | 3.7 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C)nnn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| 46900614 | 16637 | 0 | None | - | 0 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 496 | 6 | 0 | 8 | 4.4 | CO/N=C(\C)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2 | 10.1021/jm100482n | ||
| CHEMBL1241737 | 16637 | 0 | None | - | 0 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 496 | 6 | 0 | 8 | 4.4 | CO/N=C(\C)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2 | 10.1021/jm100482n | ||
| 46900782 | 16648 | 0 | None | - | 0 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 510 | 6 | 1 | 7 | 4.1 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC(C)C)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| CHEMBL1241998 | 16648 | 0 | None | - | 0 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 510 | 6 | 1 | 7 | 4.1 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC(C)C)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| 44592296 | 178836 | 0 | None | - | 0 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 434 | 4 | 0 | 5 | 3.4 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cc(F)cc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| CHEMBL469374 | 178836 | 0 | None | - | 0 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 434 | 4 | 0 | 5 | 3.4 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cc(F)cc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| 44592294 | 189263 | 0 | None | - | 0 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 430 | 4 | 0 | 5 | 3.7 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| CHEMBL511815 | 189263 | 0 | None | - | 0 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 430 | 4 | 0 | 5 | 3.7 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| 10585509 | 29753 | 2 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 229 | 6 | 1 | 2 | 3.2 | CCCNCCOc1cccc2ccccc12 | 10.1021/jm970507t | ||
| CHEMBL138683 | 29753 | 2 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 229 | 6 | 1 | 2 | 3.2 | CCCNCCOc1cccc2ccccc12 | 10.1021/jm970507t | ||
| 2543 | 3707 | 68 | None | 2 | 14 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm960552l | ||
| 5358 | 3707 | 68 | None | 2 | 14 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm960552l | ||
| 54 | 3707 | 68 | None | 2 | 14 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm960552l | ||
| CHEMBL128 | 3707 | 68 | None | 2 | 14 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm960552l | ||
| DB00669 | 3707 | 68 | None | 2 | 14 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm960552l | ||
| 2543 | 3707 | 68 | None | 2 | 14 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9604890 | ||
| 5358 | 3707 | 68 | None | 2 | 14 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9604890 | ||
| 54 | 3707 | 68 | None | 2 | 14 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9604890 | ||
| CHEMBL128 | 3707 | 68 | None | 2 | 14 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9604890 | ||
| DB00669 | 3707 | 68 | None | 2 | 14 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9604890 | ||
| 9909089 | 186968 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| CHEMBL490417 | 186968 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| 9909089 | 186968 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| CHEMBL490417 | 186968 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| 23274477 | 29121 | 1 | None | - | 0 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 229 | 5 | 0 | 2 | 3.2 | CN(C)CCCOc1cccc2ccccc12 | 10.1021/jm970507t | ||
| CHEMBL138136 | 29121 | 1 | None | - | 0 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 229 | 5 | 0 | 2 | 3.2 | CN(C)CCCOc1cccc2ccccc12 | 10.1021/jm970507t | ||
| 2199302 | 30099 | 25 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 201 | 4 | 1 | 2 | 2.4 | CNCCOc1cccc2ccccc12 | 10.1021/jm970507t | ||
| CHEMBL138958 | 30099 | 25 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 201 | 4 | 1 | 2 | 2.4 | CNCCOc1cccc2ccccc12 | 10.1021/jm970507t | ||
| 1328538 | 31584 | 8 | None | - | 0 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 291 | 6 | 0 | 2 | 4.4 | CN(CCOc1cccc2ccccc12)Cc1ccccc1 | 10.1021/jm970507t | ||
| CHEMBL140416 | 31584 | 8 | None | - | 0 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 291 | 6 | 0 | 2 | 4.4 | CN(CCOc1cccc2ccccc12)Cc1ccccc1 | 10.1021/jm970507t | ||
| 2176 | 3127 | 68 | None | - | 8 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | 10.1021/jm970507t | ||
| 4828 | 3127 | 68 | None | - | 8 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | 10.1021/jm970507t | ||
| 91 | 3127 | 68 | None | - | 8 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | 10.1021/jm970507t | ||
| CHEMBL500 | 3127 | 68 | None | - | 8 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | 10.1021/jm970507t | ||
| DB00960 | 3127 | 68 | None | - | 8 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | 10.1021/jm970507t | ||
| 14519863 | 115201 | 1 | None | - | 0 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 299 | 10 | 0 | 2 | 5.1 | CCCCN(CCCC)CCOc1cccc2ccccc12 | 10.1021/jm970507t | ||
| CHEMBL334465 | 115201 | 1 | None | - | 0 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 299 | 10 | 0 | 2 | 5.1 | CCCCN(CCCC)CCOc1cccc2ccccc12 | 10.1021/jm970507t | ||
| 9802530 | 35386 | 1 | None | -11 | 2 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 336 | 5 | 1 | 4 | 2.5 | CN(C)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | ||
| CHEMBL143767 | 35386 | 1 | None | -11 | 2 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 336 | 5 | 1 | 4 | 2.5 | CN(C)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | ||
| 14566707 | 119091 | 42 | None | - | 0 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 201 | 4 | 1 | 2 | 2.6 | NCCCOc1cccc2ccccc12 | 10.1021/jm970507t | ||
| CHEMBL342704 | 119091 | 42 | None | - | 0 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 201 | 4 | 1 | 2 | 2.6 | NCCCOc1cccc2ccccc12 | 10.1021/jm970507t | ||
| 10365683 | 113078 | 0 | None | - | 0 | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 435 | 7 | 3 | 5 | 2.4 | CC(=O)Nc1ccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)cc1 | 10.1021/jm960552l | ||
| CHEMBL331240 | 113078 | 0 | None | - | 0 | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 435 | 7 | 3 | 5 | 2.4 | CC(=O)Nc1ccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)cc1 | 10.1021/jm960552l | ||
| 44405677 | 71845 | 0 | None | - | 0 | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 473 | 5 | 0 | 8 | 2.9 | COc1cc(Cl)ccc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL196962 | 71845 | 0 | None | - | 0 | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 473 | 5 | 0 | 8 | 2.9 | COc1cc(Cl)ccc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | ||
| 22464831 | 71883 | 0 | None | - | 0 | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 423 | 4 | 0 | 7 | 2.6 | Cc1ccccc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL197078 | 71883 | 0 | None | - | 0 | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 423 | 4 | 0 | 7 | 2.6 | Cc1ccccc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | ||
| 22464606 | 72007 | 0 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 507 | 5 | 0 | 8 | 3.6 | COc1c(Cl)cc(Cl)cc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL197445 | 72007 | 0 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 507 | 5 | 0 | 8 | 3.6 | COc1c(Cl)cc(Cl)cc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | ||
| 44138104 | 178833 | 0 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 416 | 4 | 0 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1 | 10.1021/jm100482n | ||
| CHEMBL469345 | 178833 | 0 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 416 | 4 | 0 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1 | 10.1021/jm100482n | ||
| 44138104 | 178833 | 0 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 416 | 4 | 0 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| CHEMBL469345 | 178833 | 0 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 416 | 4 | 0 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| 44592209 | 179180 | 0 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 430 | 5 | 0 | 5 | 3.7 | CCN1C(=O)COc2c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc21 | 10.1016/j.bmcl.2009.02.056 | ||
| CHEMBL472290 | 179180 | 0 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 430 | 5 | 0 | 5 | 3.7 | CCN1C(=O)COc2c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc21 | 10.1016/j.bmcl.2009.02.056 | ||
| 52943861 | 19101 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 430 | 4 | 0 | 5 | 3.9 | Cc1ccc2c(N3CCN(CCc4c(F)ccc5c4ccc(=O)n5C)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| CHEMBL1289163 | 19101 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 430 | 4 | 0 | 5 | 3.9 | Cc1ccc2c(N3CCN(CCc4c(F)ccc5c4ccc(=O)n5C)CC3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| 44592207 | 189363 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)OCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| CHEMBL512724 | 189363 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)OCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| 10654938 | 78818 | 11 | None | - | 0 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 179 | 4 | 1 | 2 | 1.9 | CNCCOc1cccc(C)c1C | 10.1021/jm970507t | ||
| CHEMBL2112766 | 78818 | 11 | None | - | 0 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 179 | 4 | 1 | 2 | 1.9 | CNCCOc1cccc(C)c1C | 10.1021/jm970507t | ||
| 52947622 | 19153 | 0 | None | - | 0 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 444 | 4 | 0 | 5 | 4.3 | Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)[C@@H](C)C3)cc(F)cc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| CHEMBL1289510 | 19153 | 0 | None | - | 0 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 444 | 4 | 0 | 5 | 4.3 | Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)[C@@H](C)C3)cc(F)cc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| 22464564 | 71832 | 0 | None | - | 0 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 461 | 4 | 0 | 9 | 2.2 | CN1CCc2c(sc3ncn(CCN4CCN(c5ncnc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL196907 | 71832 | 0 | None | - | 0 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 461 | 4 | 0 | 9 | 2.2 | CN1CCc2c(sc3ncn(CCN4CCN(c5ncnc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| 22067856 | 29540 | 52 | None | - | 0 | Human | 5.5 | pKi | = | 5.5 | Functional | ChEMBL | 165 | 5 | 1 | 2 | 1.7 | CNCCCOc1ccccc1 | 10.1021/jm970507t | ||
| CHEMBL138509 | 29540 | 52 | None | - | 0 | Human | 5.5 | pKi | = | 5.5 | Functional | ChEMBL | 165 | 5 | 1 | 2 | 1.7 | CNCCCOc1ccccc1 | 10.1021/jm970507t | ||
| 22464634 | 73023 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccc6ccccc6n5)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL200951 | 73023 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccc6ccccc6n5)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| 10618751 | 35190 | 0 | None | -25 | 2 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 364 | 7 | 1 | 4 | 3.3 | CCN(CC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | ||
| CHEMBL143510 | 35190 | 0 | None | -25 | 2 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 364 | 7 | 1 | 4 | 3.3 | CCN(CC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | ||
| 52944840 | 18978 | 0 | None | - | 0 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 426 | 4 | 0 | 5 | 4.1 | Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)[C@@H](C)C3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| CHEMBL1287827 | 18978 | 0 | None | - | 0 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 426 | 4 | 0 | 5 | 4.1 | Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)[C@@H](C)C3)cccc2n1 | 10.1016/j.bmcl.2010.09.085 | ||
| 44405726 | 71965 | 0 | None | - | 0 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 507 | 5 | 0 | 8 | 3.6 | COc1cc(Cl)c(Cl)cc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL197338 | 71965 | 0 | None | - | 0 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 507 | 5 | 0 | 8 | 3.6 | COc1cc(Cl)c(Cl)cc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | ||
| 2303 | 3187 | 68 | None | - | 20 | Human | 5.4 | pKi | = | 5.4 | Functional | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm970507t | ||
| 4946 | 3187 | 68 | None | - | 20 | Human | 5.4 | pKi | = | 5.4 | Functional | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm970507t | ||
| 564 | 3187 | 68 | None | - | 20 | Human | 5.4 | pKi | = | 5.4 | Functional | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm970507t | ||
| 63 | 3187 | 68 | None | - | 20 | Human | 5.4 | pKi | = | 5.4 | Functional | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm970507t | ||
| 91536 | 3187 | 68 | None | - | 20 | Human | 5.4 | pKi | = | 5.4 | Functional | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm970507t | ||
| CHEMBL27 | 3187 | 68 | None | - | 20 | Human | 5.4 | pKi | = | 5.4 | Functional | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm970507t | ||
| CHEMBL452861 | 3187 | 68 | None | - | 20 | Human | 5.4 | pKi | = | 5.4 | Functional | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm970507t | ||
| DB00571 | 3187 | 68 | None | - | 20 | Human | 5.4 | pKi | = | 5.4 | Functional | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm970507t | ||
| 44405665 | 73021 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 507 | 5 | 0 | 8 | 3.3 | COc1ccc(C(F)(F)F)cc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL200949 | 73021 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 507 | 5 | 0 | 8 | 3.3 | COc1ccc(C(F)(F)F)cc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | ||
| 10635169 | 31582 | 0 | None | - | 0 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 261 | 7 | 0 | 2 | 4.1 | CCCN(C)CCOc1ccccc1C1CCCC1 | 10.1021/jm970507t | ||
| CHEMBL140415 | 31582 | 0 | None | - | 0 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 261 | 7 | 0 | 2 | 4.1 | CCCN(C)CCOc1ccccc1C1CCCC1 | 10.1021/jm970507t | ||
| 13520547 | 27004 | 1 | None | - | 0 | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 243 | 6 | 0 | 2 | 3.6 | CN(C)CCCCOc1cccc2ccccc12 | 10.1021/jm970507t | ||
| CHEMBL136470 | 27004 | 1 | None | - | 0 | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 243 | 6 | 0 | 2 | 3.6 | CN(C)CCCCOc1cccc2ccccc12 | 10.1021/jm970507t | ||
| 44592249 | 178851 | 0 | None | - | 0 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 444 | 5 | 0 | 5 | 4.0 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C(C)C)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| CHEMBL469567 | 178851 | 0 | None | - | 0 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 444 | 5 | 0 | 5 | 4.0 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C(C)C)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| 44592250 | 178852 | 0 | None | - | 0 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 442 | 5 | 0 | 5 | 3.8 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C4CC4)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| CHEMBL469568 | 178852 | 0 | None | - | 0 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 442 | 5 | 0 | 5 | 3.8 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C4CC4)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| 22464804 | 73022 | 0 | None | - | 0 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 489 | 5 | 0 | 8 | 3.4 | COc1ccc2ccccc2c1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL200950 | 73022 | 0 | None | - | 0 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 489 | 5 | 0 | 8 | 3.4 | COc1ccc2ccccc2c1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | ||
| 44405587 | 133565 | 0 | None | - | 0 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 495 | 6 | 0 | 8 | 3.7 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccccc5OCC(C)(C)C)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL371094 | 133565 | 0 | None | - | 0 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 495 | 6 | 0 | 8 | 3.7 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccccc5OCC(C)(C)C)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| 22464614 | 71858 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 469 | 6 | 0 | 9 | 2.3 | COc1ccc(OC)c(N2CCN(CCn3cnc4sc5c(c4c3=O)CCN(C)C5)CC2)c1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL197011 | 71858 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 469 | 6 | 0 | 9 | 2.3 | COc1ccc(OC)c(N2CCN(CCn3cnc4sc5c(c4c3=O)CCN(C)C5)CC2)c1 | 10.1016/j.bmcl.2005.04.077 | ||
| 37732 | 26823 | 73 | None | - | 0 | Human | 5.2 | pKi | = | 5.2 | Functional | ChEMBL | 151 | 4 | 1 | 2 | 1.3 | CNCCOc1ccccc1 | 10.1021/jm970507t | ||
| CHEMBL136311 | 26823 | 73 | None | - | 0 | Human | 5.2 | pKi | = | 5.2 | Functional | ChEMBL | 151 | 4 | 1 | 2 | 1.3 | CNCCOc1ccccc1 | 10.1021/jm970507t | ||
| 44592251 | 178907 | 0 | None | - | 0 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 456 | 6 | 0 | 5 | 4.0 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5CC4CC4)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| CHEMBL469995 | 178907 | 0 | None | - | 0 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 456 | 6 | 0 | 5 | 4.0 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5CC4CC4)CC3)cccc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| 5 | 139 | 72 | None | -19 | 26 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm960552l | ||
| 5202 | 139 | 72 | None | -19 | 26 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm960552l | ||
| CHEMBL39 | 139 | 72 | None | -19 | 26 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm960552l | ||
| DB08839 | 139 | 72 | None | -19 | 26 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm960552l | ||
| 10560632 | 26732 | 1 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 215 | 5 | 1 | 2 | 2.8 | CCNCCOc1cccc2ccccc12 | 10.1021/jm970507t | ||
| CHEMBL136236 | 26732 | 1 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 215 | 5 | 1 | 2 | 2.8 | CCNCCOc1cccc2ccccc12 | 10.1021/jm970507t | ||
| 46900608 | 16631 | 0 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 427 | 4 | 0 | 8 | 2.8 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nnnn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| CHEMBL1241639 | 16631 | 0 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 427 | 4 | 0 | 8 | 2.8 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nnnn4-5)CC3)cccc2n1 | 10.1021/jm100482n | ||
| 22002244 | 72343 | 0 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 473 | 5 | 0 | 8 | 2.9 | COc1ccc(Cl)cc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL198462 | 72343 | 0 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 473 | 5 | 0 | 8 | 2.9 | COc1ccc(Cl)cc1N1CCN(CCn2cnc3sc4c(c3c2=O)CCN(C)C4)CC1 | 10.1016/j.bmcl.2005.04.077 | ||
| 14519865 | 31587 | 1 | None | - | 0 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 243 | 6 | 0 | 2 | 3.6 | CCCN(C)CCOc1cccc2ccccc12 | 10.1021/jm970507t | ||
| CHEMBL140417 | 31587 | 1 | None | - | 0 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 243 | 6 | 0 | 2 | 3.6 | CCCN(C)CCOc1cccc2ccccc12 | 10.1021/jm970507t | ||
| 10263828 | 30873 | 17 | None | - | 0 | Human | 5.1 | pKi | = | 5.1 | Functional | ChEMBL | 243 | 6 | 1 | 2 | 3.6 | CC(C)NCCCOc1cccc2ccccc12 | 10.1021/jm970507t | ||
| CHEMBL139737 | 30873 | 17 | None | - | 0 | Human | 5.1 | pKi | = | 5.1 | Functional | ChEMBL | 243 | 6 | 1 | 2 | 3.6 | CC(C)NCCCOc1cccc2ccccc12 | 10.1021/jm970507t | ||
| 44592334 | 178857 | 0 | None | - | 0 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 448 | 5 | 0 | 5 | 3.8 | Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5C)CC3)cc(F)cc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| CHEMBL469589 | 178857 | 0 | None | - | 0 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 448 | 5 | 0 | 5 | 3.8 | Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5C)CC3)cc(F)cc2n1 | 10.1016/j.bmcl.2009.02.056 | ||
| 10691904 | 35620 | 0 | None | -3 | 2 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 392 | 9 | 1 | 4 | 4.1 | CCCN(CCC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | ||
| CHEMBL143967 | 35620 | 0 | None | -3 | 2 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 392 | 9 | 1 | 4 | 4.1 | CCCN(CCC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | ||
| 11662592 | 72344 | 0 | None | 15 | 2 | Human | 8.0 | pKi | = | 8.0 | Functional | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccnc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| CHEMBL198463 | 72344 | 0 | None | 15 | 2 | Human | 8.0 | pKi | = | 8.0 | Functional | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccnc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | ||
| 3604129 | 30264 | 5 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 215 | 4 | 0 | 2 | 2.8 | CN(C)CCOc1cccc2ccccc12 | 10.1021/jm970507t | ||
| CHEMBL139103 | 30264 | 5 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 215 | 4 | 0 | 2 | 2.8 | CN(C)CCOc1cccc2ccccc12 | 10.1021/jm970507t | ||
| 2105 | 3054 | 37 | None | -1 | 25 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | ||
| 47811 | 3054 | 37 | None | -1 | 25 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | ||
| 48 | 3054 | 37 | None | -1 | 25 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | ||
| CHEMBL531 | 3054 | 37 | None | -1 | 25 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | ||
| DB01186 | 3054 | 37 | None | -1 | 25 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | ||
| 4223 | 3992 | 94 | None | -707 | 16 | Rat | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| 6918314 | 3992 | 94 | None | -707 | 16 | Rat | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| 7427 | 3992 | 94 | None | -707 | 16 | Rat | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| CHEMBL439849 | 3992 | 94 | None | -707 | 16 | Rat | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| DB06684 | 3992 | 94 | None | -707 | 16 | Rat | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| 1220 | 187 | 55 | None | -109 | 9 | Human | 6.2 | pIC50 | = | 6.2 | Functional | Guide to Pharmacology | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 9303569 | ||
| 31 | 187 | 55 | None | -109 | 9 | Human | 6.2 | pIC50 | = | 6.2 | Functional | Guide to Pharmacology | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 9303569 | ||
| 7 | 187 | 55 | None | -109 | 9 | Human | 6.2 | pIC50 | = | 6.2 | Functional | Guide to Pharmacology | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 9303569 | ||
| CHEMBL56 | 187 | 55 | None | -109 | 9 | Human | 6.2 | pIC50 | = | 6.2 | Functional | Guide to Pharmacology | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 9303569 | ||
| 137 | 138 | 0 | None | -1 | 2 | Human | 11.9 | pIC50 | None | 11.9 | Functional | Guide to Pharmacology | None | None | None | None | 9774213 | ||||
| 7048565 | 138 | 0 | None | -1 | 2 | Human | 11.9 | pIC50 | None | 11.9 | Functional | Guide to Pharmacology | None | None | None | None | 9774213 | ||||
| 7048566 | 138 | 0 | None | -1 | 2 | Human | 11.9 | pIC50 | None | 11.9 | Functional | Guide to Pharmacology | None | None | None | None | 9774213 | ||||
| 1524 | 2181 | 96 | None | -125 | 18 | Human | 5.3 | pIC50 | None | 5.3 | Functional | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 9303569 | ||
| 1524 | 2181 | 96 | None | -125 | 18 | Human | 5.3 | pIC50 | None | 5.3 | Functional | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 9605573 | ||
| 197 | 2181 | 96 | None | -125 | 18 | Human | 5.3 | pIC50 | None | 5.3 | Functional | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 9303569 | ||
| 197 | 2181 | 96 | None | -125 | 18 | Human | 5.3 | pIC50 | None | 5.3 | Functional | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 9605573 | ||
| 3822 | 2181 | 96 | None | -125 | 18 | Human | 5.3 | pIC50 | None | 5.3 | Functional | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 9303569 | ||
| 3822 | 2181 | 96 | None | -125 | 18 | Human | 5.3 | pIC50 | None | 5.3 | Functional | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 9605573 | ||
| 88 | 2181 | 96 | None | -125 | 18 | Human | 5.3 | pIC50 | None | 5.3 | Functional | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 9303569 | ||
| 88 | 2181 | 96 | None | -125 | 18 | Human | 5.3 | pIC50 | None | 5.3 | Functional | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 9605573 | ||
| CHEMBL51 | 2181 | 96 | None | -125 | 18 | Human | 5.3 | pIC50 | None | 5.3 | Functional | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 9303569 | ||
| CHEMBL51 | 2181 | 96 | None | -125 | 18 | Human | 5.3 | pIC50 | None | 5.3 | Functional | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 9605573 | ||
| DB12465 | 2181 | 96 | None | -125 | 18 | Human | 5.3 | pIC50 | None | 5.3 | Functional | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 9303569 | ||
| DB12465 | 2181 | 96 | None | -125 | 18 | Human | 5.3 | pIC50 | None | 5.3 | Functional | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 9605573 | ||
| 5074 | 3332 | 80 | None | -33 | 8 | Human | 6.3 | pIC50 | None | 6.3 | Functional | Guide to Pharmacology | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | 9303569 | ||
| 5074 | 3332 | 80 | None | -33 | 8 | Human | 6.3 | pIC50 | None | 6.3 | Functional | Guide to Pharmacology | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | 9605573 | ||
| 97 | 3332 | 80 | None | -33 | 8 | Human | 6.3 | pIC50 | None | 6.3 | Functional | Guide to Pharmacology | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | 9303569 | ||
| 97 | 3332 | 80 | None | -33 | 8 | Human | 6.3 | pIC50 | None | 6.3 | Functional | Guide to Pharmacology | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | 9605573 | ||
| CHEMBL267777 | 3332 | 80 | None | -33 | 8 | Human | 6.3 | pIC50 | None | 6.3 | Functional | Guide to Pharmacology | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | 9303569 | ||
| CHEMBL267777 | 3332 | 80 | None | -33 | 8 | Human | 6.3 | pIC50 | None | 6.3 | Functional | Guide to Pharmacology | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | 9605573 | ||
| DB12693 | 3332 | 80 | None | -33 | 8 | Human | 6.3 | pIC50 | None | 6.3 | Functional | Guide to Pharmacology | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | 9303569 | ||
| DB12693 | 3332 | 80 | None | -33 | 8 | Human | 6.3 | pIC50 | None | 6.3 | Functional | Guide to Pharmacology | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | 9605573 | ||
| 16 | 2253 | 8 | None | -177 | 5 | Human | 6.8 | pIC50 | None | 6.8 | Functional | Guide to Pharmacology | 462 | 9 | 3 | 6 | 3.6 | OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10585208 | ||
| 9847194 | 2253 | 8 | None | -177 | 5 | Human | 6.8 | pIC50 | None | 6.8 | Functional | Guide to Pharmacology | 462 | 9 | 3 | 6 | 3.6 | OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10585208 | ||
| CHEMBL313714 | 2253 | 8 | None | -177 | 5 | Human | 6.8 | pIC50 | None | 6.8 | Functional | Guide to Pharmacology | 462 | 9 | 3 | 6 | 3.6 | OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10585208 | ||
| 46 | 2905 | 0 | None | - | 1 | Human | 7.1 | pIC50 | None | 7.1 | Functional | Guide to Pharmacology | 420 | 4 | 0 | 6 | 4.0 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2C | 9605573 | ||
| 71351 | 2905 | 0 | None | - | 1 | Human | 7.1 | pIC50 | None | 7.1 | Functional | Guide to Pharmacology | 420 | 4 | 0 | 6 | 4.0 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2C | 9605573 | ||
| CHEMBL2104619 | 2905 | 0 | None | - | 1 | Human | 7.1 | pIC50 | None | 7.1 | Functional | Guide to Pharmacology | 420 | 4 | 0 | 6 | 4.0 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2C | 9605573 | ||
| DB06229 | 2905 | 0 | None | - | 1 | Human | 7.1 | pIC50 | None | 7.1 | Functional | Guide to Pharmacology | 420 | 4 | 0 | 6 | 4.0 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2C | 9605573 | ||
| 110 | 1174 | 18 | None | -1 | 2 | Human | 7.6 | pIC50 | None | 7.6 | Functional | Guide to Pharmacology | 321 | 5 | 2 | 3 | 1.9 | CNS(=O)(=O)Cc1ccc2c(c1)c(c[nH]2)C[C@H]1CCCN1C | 9303569 | ||
| 132552 | 1174 | 18 | None | -1 | 2 | Human | 7.6 | pIC50 | None | 7.6 | Functional | Guide to Pharmacology | 321 | 5 | 2 | 3 | 1.9 | CNS(=O)(=O)Cc1ccc2c(c1)c(c[nH]2)C[C@H]1CCCN1C | 9303569 | ||
| CHEMBL159332 | 1174 | 18 | None | -1 | 2 | Human | 7.6 | pIC50 | None | 7.6 | Functional | Guide to Pharmacology | 321 | 5 | 2 | 3 | 1.9 | CNS(=O)(=O)Cc1ccc2c(c1)c(c[nH]2)C[C@H]1CCCN1C | 9303569 | ||
| 113 | 1852 | 14 | None | - | 1 | Human | 7.4 | pKB | = | 7.4 | Functional | Guide to Pharmacology | 375 | 7 | 2 | 4 | 4.2 | CN(CCCc1cc(ccc1O)C(=O)Nc1ccc(cc1)c1ccncc1)C | 11888546 | ||
| 128018 | 1852 | 14 | None | - | 1 | Human | 7.4 | pKB | = | 7.4 | Functional | Guide to Pharmacology | 375 | 7 | 2 | 4 | 4.2 | CN(CCCc1cc(ccc1O)C(=O)Nc1ccc(cc1)c1ccncc1)C | 11888546 | ||
| CHEMBL119264 | 1852 | 14 | None | - | 1 | Human | 7.4 | pKB | = | 7.4 | Functional | Guide to Pharmacology | 375 | 7 | 2 | 4 | 4.2 | CN(CCCc1cc(ccc1O)C(=O)Nc1ccc(cc1)c1ccncc1)C | 11888546 | ||
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Similar- ity |
Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
Assay Type |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
| 19066203 | 12089 | 0 | None | 47 | 3 | Human | 8.7 | pEC50 | = | 8.7 | Binding | ChEMBL | 437 | 4 | 1 | 5 | 3.4 | COc1ccc(NC(=O)N2CCN(c3ccc(C)cc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL1183904 | 12089 | 0 | None | 47 | 3 | Human | 8.7 | pEC50 | = | 8.7 | Binding | ChEMBL | 437 | 4 | 1 | 5 | 3.4 | COc1ccc(NC(=O)N2CCN(c3ccc(C)cc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL323986 | 12089 | 0 | None | 47 | 3 | Human | 8.7 | pEC50 | = | 8.7 | Binding | ChEMBL | 437 | 4 | 1 | 5 | 3.4 | COc1ccc(NC(=O)N2CCN(c3ccc(C)cc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| 19066163 | 11386 | 0 | None | 28 | 3 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 437 | 4 | 1 | 5 | 3.4 | COc1ccc(NC(=O)N2CCN(c3c(C)cccc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL111302 | 11386 | 0 | None | 28 | 3 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 437 | 4 | 1 | 5 | 3.4 | COc1ccc(NC(=O)N2CCN(c3c(C)cccc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL1180017 | 11386 | 0 | None | 28 | 3 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 437 | 4 | 1 | 5 | 3.4 | COc1ccc(NC(=O)N2CCN(c3c(C)cccc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| 5 | 139 | 72 | None | -13 | 54 | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00170a007 | |||
| 5202 | 139 | 72 | None | -13 | 54 | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00170a007 | |||
| CHEMBL39 | 139 | 72 | None | -13 | 54 | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00170a007 | |||
| DB08839 | 139 | 72 | None | -13 | 54 | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00170a007 | |||
| CHEMBL5078078 | 214535 | 7 | None | - | 0 | Human | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | None | None | None | CC(C)(O)c1ccc(N2Cc3c(ccnc3-c3ccc(F)cc3OCC(F)(F)F)C2=O)cc1 | 10.6019/CHEMBL5303768 | |||||
| 5 | 139 | 72 | None | -11 | 54 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00170a007 | |||
| 5202 | 139 | 72 | None | -11 | 54 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00170a007 | |||
| CHEMBL39 | 139 | 72 | None | -11 | 54 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00170a007 | |||
| DB08839 | 139 | 72 | None | -11 | 54 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00170a007 | |||
| 137634921 | 156250 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 586 | 3 | 2 | 9 | 4.5 | O=C1CCc2cc3cc(c2N1Cc1ccccc1)OC/C=C/CO[C@H]1C[C@@H](CO)N(C1)c1cc(n2ncc(Cl)c2n1)N3 | 10.1021/acs.jmedchem.7b00359 | |||
| CHEMBL4064865 | 156250 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 586 | 3 | 2 | 9 | 4.5 | O=C1CCc2cc3cc(c2N1Cc1ccccc1)OC/C=C/CO[C@H]1C[C@@H](CO)N(C1)c1cc(n2ncc(Cl)c2n1)N3 | 10.1021/acs.jmedchem.7b00359 | |||
| 11539632 | 70561 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 447 | 8 | 1 | 5 | 4.8 | Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12 | 10.1021/jm050103y | |||
| CHEMBL194837 | 70561 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 447 | 8 | 1 | 5 | 4.8 | Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12 | 10.1021/jm050103y | |||
| 1043 | 1582 | 14 | None | 4 | 28 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
| 149 | 1582 | 14 | None | 4 | 28 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
| 8223 | 1582 | 14 | None | 4 | 28 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
| CHEMBL442 | 1582 | 14 | None | 4 | 28 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
| DB00696 | 1582 | 14 | None | 4 | 28 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
| 9952249 | 52672 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 388 | 6 | 1 | 7 | 2.3 | c1cnc(N2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1 | 10.1021/jm980569z | |||
| CHEMBL159396 | 52672 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 388 | 6 | 1 | 7 | 2.3 | c1cnc(N2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1 | 10.1021/jm980569z | |||
| 9846928 | 39679 | 15 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 457 | 6 | 3 | 5 | 4.0 | COc1ccc(NC(=O)c2ccc(-c3ccc(C(=N)N)cc3C)cc2)cc1N1CCN(C)CC1 | 10.1021/jm990397l | |||
| CHEMBL147503 | 39679 | 15 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 457 | 6 | 3 | 5 | 4.0 | COc1ccc(NC(=O)c2ccc(-c3ccc(C(=N)N)cc3C)cc2)cc1N1CCN(C)CC1 | 10.1021/jm990397l | |||
| 2543 | 3707 | 68 | None | -3 | 32 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm000956k | |||
| 5358 | 3707 | 68 | None | -3 | 32 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm000956k | |||
| 54 | 3707 | 68 | None | -3 | 32 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm000956k | |||
| CHEMBL128 | 3707 | 68 | None | -3 | 32 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm000956k | |||
| DB00669 | 3707 | 68 | None | -3 | 32 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm000956k | |||
| 11333554 | 96661 | 22 | None | - | 1 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 223 | 1 | 2 | 2 | 2.4 | N#Cc1ccc2[nH]cc(C3=CCNCC3)c2c1 | 10.1021/jm00170a007 | |||
| CHEMBL26379 | 96661 | 22 | None | - | 1 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 223 | 1 | 2 | 2 | 2.4 | N#Cc1ccc2[nH]cc(C3=CCNCC3)c2c1 | 10.1021/jm00170a007 | |||
| 10531 | 1420 | 21 | None | -5 | 23 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
| 121 | 1420 | 21 | None | -5 | 23 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
| 888 | 1420 | 21 | None | -5 | 23 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
| CHEMBL1732 | 1420 | 21 | None | -5 | 23 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
| DB00320 | 1420 | 21 | None | -5 | 23 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
| 10323598 | 38899 | 21 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(NC(=O)c2ccc(-c3ccc(-c4nnc(C)o4)cc3C)cc2)cc1N1CCN(C)CC1 | 10.1021/jm990397l | |||
| CHEMBL146735 | 38899 | 21 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(NC(=O)c2ccc(-c3ccc(-c4nnc(C)o4)cc3C)cc2)cc1N1CCN(C)CC1 | 10.1021/jm990397l | |||
| 15646678 | 96659 | 27 | None | - | 1 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 214 | 1 | 3 | 2 | 2.3 | Oc1ccc2[nH]cc(C3=CCNCC3)c2c1 | 10.1021/jm00170a007 | |||
| CHEMBL26378 | 96659 | 27 | None | - | 1 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 214 | 1 | 3 | 2 | 2.3 | Oc1ccc2[nH]cc(C3=CCNCC3)c2c1 | 10.1021/jm00170a007 | |||
| 9881526 | 101248 | 1 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 255 | 4 | 1 | 4 | 1.9 | CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12 | 10.1021/jm980569z | |||
| CHEMBL296161 | 101248 | 1 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 255 | 4 | 1 | 4 | 1.9 | CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12 | 10.1021/jm980569z | |||
| 9881526 | 101248 | 1 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 255 | 4 | 1 | 4 | 1.9 | CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12 | 10.1021/jm9805687 | |||
| CHEMBL296161 | 101248 | 1 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 255 | 4 | 1 | 4 | 1.9 | CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12 | 10.1021/jm9805687 | |||
| 10718709 | 39284 | 19 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 458 | 6 | 2 | 5 | 3.8 | COc1ccc(NC(=O)c2ccc(-c3ccc(C(N)=O)cc3C)cc2)cc1N1CCN(C)CC1 | 10.1021/jm990397l | |||
| CHEMBL147071 | 39284 | 19 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 458 | 6 | 2 | 5 | 3.8 | COc1ccc(NC(=O)c2ccc(-c3ccc(C(N)=O)cc3C)cc2)cc1N1CCN(C)CC1 | 10.1021/jm990397l | |||
| 9881526 | 101248 | 1 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 255 | 4 | 1 | 4 | 1.9 | CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12 | 10.1021/jm9704558 | |||
| CHEMBL296161 | 101248 | 1 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 255 | 4 | 1 | 4 | 1.9 | CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12 | 10.1021/jm9704558 | |||
| 107780 | 1844 | 54 | None | -4 | 17 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm9811054 | |||
| 14 | 1844 | 54 | None | -4 | 17 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm9811054 | |||
| CHEMBL15928 | 1844 | 54 | None | -4 | 17 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm9811054 | |||
| 107780 | 1844 | 54 | None | -4 | 17 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm990397l | |||
| 14 | 1844 | 54 | None | -4 | 17 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm990397l | |||
| CHEMBL15928 | 1844 | 54 | None | -4 | 17 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm990397l | |||
| 11344959 | 97293 | 38 | None | - | 1 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 216 | 1 | 2 | 1 | 2.7 | Fc1ccc2[nH]cc(C3=CCNCC3)c2c1 | 10.1021/jm00170a007 | |||
| CHEMBL26906 | 97293 | 38 | None | - | 1 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 216 | 1 | 2 | 1 | 2.7 | Fc1ccc2[nH]cc(C3=CCNCC3)c2c1 | 10.1021/jm00170a007 | |||
| 2543 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9910021 | |||
| 5358 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9910021 | |||
| 54 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9910021 | |||
| CHEMBL128 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9910021 | |||
| DB00669 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9910021 | |||
| 1588 | 2325 | 27 | None | -58 | 44 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | nan | |||
| 28864 | 2325 | 27 | None | -58 | 44 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | nan | |||
| 43 | 2325 | 27 | None | -58 | 44 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | nan | |||
| CHEMBL157138 | 2325 | 27 | None | -58 | 44 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | nan | |||
| DB00589 | 2325 | 27 | None | -58 | 44 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | nan | |||
| 10552663 | 121139 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 478 | 8 | 1 | 6 | 3.5 | CN(C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)S(=O)(=O)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL357634 | 121139 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 478 | 8 | 1 | 6 | 3.5 | CN(C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)S(=O)(=O)c1ccccc1 | 10.1021/jm9910021 | |||
| 10578117 | 44041 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 529 | 8 | 1 | 7 | 5.4 | Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc(OCCF)c(N5CCN(C)CC5)c4)cc3)c(C)c2)no1 | 10.1021/jm990397l | |||
| CHEMBL151420 | 44041 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 529 | 8 | 1 | 7 | 5.4 | Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc(OCCF)c(N5CCN(C)CC5)c4)cc3)c(C)c2)no1 | 10.1021/jm990397l | |||
| 10790076 | 39988 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 458 | 10 | 3 | 6 | 3.3 | OC[C@@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| CHEMBL147853 | 39988 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 458 | 10 | 3 | 6 | 3.3 | OC[C@@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| 10076176 | 106435 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 547 | 18 | 4 | 7 | 4.8 | O=S(=O)(c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)C1CCCC1 | 10.1021/jm401532g | |||
| CHEMBL3126382 | 106435 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 547 | 18 | 4 | 7 | 4.8 | O=S(=O)(c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)C1CCCC1 | 10.1021/jm401532g | |||
| CHEMBL3139683 | 106435 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 547 | 18 | 4 | 7 | 4.8 | O=S(=O)(c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)C1CCCC1 | 10.1021/jm401532g | |||
| 10576874 | 41976 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 485 | 9 | 2 | 6 | 4.2 | CC(=O)Nc1ccc(CN(C)C2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
| CHEMBL149488 | 41976 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 485 | 9 | 2 | 6 | 4.2 | CC(=O)Nc1ccc(CN(C)C2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
| 10836986 | 168307 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 443 | 9 | 3 | 5 | 4.1 | OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4ccnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL434125 | 168307 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 443 | 9 | 3 | 5 | 4.1 | OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4ccnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| 10526736 | 10222 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1ccccc1CCN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9704560 | |||
| CHEMBL116031 | 10222 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1ccccc1CCN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9704560 | |||
| 10671211 | 202727 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 449 | 6 | 0 | 5 | 4.8 | Cn1c(=O)sc2cc(CCCCN3CCN(c4cccc(C(F)(F)F)c4)CC3)ccc21 | 10.1021/jm970298c | |||
| CHEMBL61818 | 202727 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 449 | 6 | 0 | 5 | 4.8 | Cn1c(=O)sc2cc(CCCCN3CCN(c4cccc(C(F)(F)F)c4)CC3)ccc21 | 10.1021/jm970298c | |||
| 122186880 | 122980 | 0 | None | - | 5 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 415 | 3 | 0 | 5 | 4.8 | COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4 | 10.1016/j.bmcl.2015.07.012 | |||
| CHEMBL3608450 | 122980 | 0 | None | - | 5 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 415 | 3 | 0 | 5 | 4.8 | COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4 | 10.1016/j.bmcl.2015.07.012 | |||
| 2470 | 3653 | 50 | None | -43651 | 59 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm00401a007 | |||
| 3300 | 3653 | 50 | None | -43651 | 59 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm00401a007 | |||
| 5265 | 3653 | 50 | None | -43651 | 59 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm00401a007 | |||
| 99 | 3653 | 50 | None | -43651 | 59 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm00401a007 | |||
| CHEMBL267930 | 3653 | 50 | None | -43651 | 59 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm00401a007 | |||
| 10476735 | 13731 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 411 | 9 | 0 | 7 | 3.5 | CCCN(CCCCn1c(=O)oc2cccnc21)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL1195096 | 13731 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 411 | 9 | 0 | 7 | 3.5 | CCCN(CCCCn1c(=O)oc2cccnc21)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL553833 | 13731 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 411 | 9 | 0 | 7 | 3.5 | CCCN(CCCCn1c(=O)oc2cccnc21)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| 10342423 | 99469 | 0 | None | - | 1 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 426 | 11 | 1 | 5 | 3.9 | CCCN(CCCCNC(=O)c1ccccc1OC)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL28312 | 99469 | 0 | None | - | 1 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 426 | 11 | 1 | 5 | 3.9 | CCCN(CCCCNC(=O)c1ccccc1OC)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL48925 | 99469 | 0 | None | - | 1 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 426 | 11 | 1 | 5 | 3.9 | CCCN(CCCCNC(=O)c1ccccc1OC)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| 3082597 | 99559 | 8 | None | - | 1 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 263 | 6 | 0 | 3 | 3.1 | CCCN(CCC)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL283606 | 99559 | 8 | None | - | 1 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 263 | 6 | 0 | 3 | 3.1 | CCCN(CCC)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| 10072866 | 197475 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 458 | 9 | 0 | 6 | 3.3 | CCCN(CCCCN1C(=O)c2ccccc2S1(=O)=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL51561 | 197475 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 458 | 9 | 0 | 6 | 3.3 | CCCN(CCCCN1C(=O)c2ccccc2S1(=O)=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL56990 | 197475 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 458 | 9 | 0 | 6 | 3.3 | CCCN(CCCCN1C(=O)c2ccccc2S1(=O)=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| 10671315 | 203011 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 451 | 8 | 1 | 5 | 4.6 | FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(OCc2ccccc2)CC1 | 10.1021/jm981133m | |||
| CHEMBL63258 | 203011 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 451 | 8 | 1 | 5 | 4.6 | FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(OCc2ccccc2)CC1 | 10.1021/jm981133m | |||
| 10575553 | 203039 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 450 | 8 | 1 | 5 | 3.6 | Fc1cccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | |||
| CHEMBL63432 | 203039 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 450 | 8 | 1 | 5 | 3.6 | Fc1cccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | |||
| 10767140 | 203370 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 482 | 8 | 1 | 5 | 4.5 | CC(CN1CCN(CC(F)(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1 | 10.1021/jm981133m | |||
| CHEMBL65215 | 203370 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 482 | 8 | 1 | 5 | 4.5 | CC(CN1CCN(CC(F)(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1 | 10.1021/jm981133m | |||
| 121852 | 10166 | 7 | None | - | 1 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL11592 | 10166 | 7 | None | - | 1 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL301060 | 10166 | 7 | None | - | 1 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| 10251234 | 11245 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 414 | 9 | 0 | 5 | 3.3 | CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL1178932 | 11245 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 414 | 9 | 0 | 5 | 3.3 | CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL50530 | 11245 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 414 | 9 | 0 | 5 | 3.3 | CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| 10024943 | 97390 | 0 | None | - | 1 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 416 | 9 | 0 | 5 | 3.7 | CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL26975 | 97390 | 0 | None | - | 1 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 416 | 9 | 0 | 5 | 3.7 | CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL52485 | 97390 | 0 | None | - | 1 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 416 | 9 | 0 | 5 | 3.7 | CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| 121852 | 10166 | 7 | None | - | 1 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm950861w | |||
| CHEMBL11592 | 10166 | 7 | None | - | 1 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm950861w | |||
| CHEMBL301060 | 10166 | 7 | None | - | 1 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm950861w | |||
| 10571450 | 101871 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 374 | 3 | 0 | 4 | 4.3 | Cc1ccc2c(c1)nc(N1CCN(Cc3ccc(F)cc3)CC1)c1cccn12 | 10.1021/jm960501o | |||
| CHEMBL300692 | 101871 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 374 | 3 | 0 | 4 | 4.3 | Cc1ccc2c(c1)nc(N1CCN(Cc3ccc(F)cc3)CC1)c1cccn12 | 10.1021/jm960501o | |||
| 57397383 | 67952 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 374 | 2 | 2 | 4 | 3.8 | Cc1nnc(-c2ccc(C)c(-c3ccc4c(c3)NC(=O)C43CCOCC3)c2)[nH]1 | 10.1016/j.bmcl.2011.09.006 | |||
| CHEMBL1911194 | 67952 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 374 | 2 | 2 | 4 | 3.8 | Cc1nnc(-c2ccc(C)c(-c3ccc4c(c3)NC(=O)C43CCOCC3)c2)[nH]1 | 10.1016/j.bmcl.2011.09.006 | |||
| 10014217 | 99748 | 0 | None | - | 1 | Rat | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 233 | 2 | 0 | 3 | 2.1 | COc1cccc2c1CC(N1CCCC1)CO2 | 10.1021/jm00038a007 | |||
| CHEMBL285010 | 99748 | 0 | None | - | 1 | Rat | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 233 | 2 | 0 | 3 | 2.1 | COc1cccc2c1CC(N1CCCC1)CO2 | 10.1021/jm00038a007 | |||
| 10719202 | 56557 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 471 | 8 | 1 | 6 | 3.1 | CN(C)C(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
| CHEMBL164035 | 56557 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 471 | 8 | 1 | 6 | 3.1 | CN(C)C(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
| 9863146 | 194992 | 1 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 348 | 3 | 0 | 5 | 3.9 | c1ccc(CN2CCN(c3nc4ccsc4n4cccc34)CC2)cc1 | 10.1021/jm950543x | |||
| CHEMBL54720 | 194992 | 1 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 348 | 3 | 0 | 5 | 3.9 | c1ccc(CN2CCN(c3nc4ccsc4n4cccc34)CC2)cc1 | 10.1021/jm950543x | |||
| 9863146 | 194992 | 1 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 348 | 3 | 0 | 5 | 3.9 | c1ccc(CN2CCN(c3nc4ccsc4n4cccc34)CC2)cc1 | 10.1021/jm960501o | |||
| CHEMBL54720 | 194992 | 1 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 348 | 3 | 0 | 5 | 3.9 | c1ccc(CN2CCN(c3nc4ccsc4n4cccc34)CC2)cc1 | 10.1021/jm960501o | |||
| 10852612 | 203432 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 312 | 3 | 0 | 5 | 3.1 | c1cc2c(N3CCN(CC4CC4)CC3)nc3ccsc3n2c1 | 10.1021/jm950543x | |||
| CHEMBL65736 | 203432 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 312 | 3 | 0 | 5 | 3.1 | c1cc2c(N3CCN(CC4CC4)CC3)nc3ccsc3n2c1 | 10.1021/jm950543x | |||
| 31101 | 729 | 40 | None | -48 | 36 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | nan | |||
| 35 | 729 | 40 | None | -48 | 36 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | nan | |||
| 403 | 729 | 40 | None | -48 | 36 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | nan | |||
| CHEMBL493 | 729 | 40 | None | -48 | 36 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | nan | |||
| DB01200 | 729 | 40 | None | -48 | 36 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | nan | |||
| 10849641 | 113090 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 270 | 1 | 1 | 4 | 2.0 | Fc1cccc2nc(N3CCNCC3)c3cccn3c12 | 10.1021/jm970376w | |||
| CHEMBL331304 | 113090 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 270 | 1 | 1 | 4 | 2.0 | Fc1cccc2nc(N3CCNCC3)c3cccn3c12 | 10.1021/jm970376w | |||
| 10590360 | 203336 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 300 | 3 | 0 | 5 | 3.1 | CCCN1CCN(c2nc3ccsc3n3cccc23)CC1 | 10.1021/jm950543x | |||
| CHEMBL64948 | 203336 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 300 | 3 | 0 | 5 | 3.1 | CCCN1CCN(c2nc3ccsc3n3cccc23)CC1 | 10.1021/jm950543x | |||
| 10621021 | 203384 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 400 | 7 | 1 | 5 | 3.5 | c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/acs.jmedchem.5b00258 | |||
| CHEMBL65367 | 203384 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 400 | 7 | 1 | 5 | 3.5 | c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/acs.jmedchem.5b00258 | |||
| 2543 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm980569z | |||
| 5358 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm980569z | |||
| 54 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm980569z | |||
| CHEMBL128 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm980569z | |||
| DB00669 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm980569z | |||
| 10621021 | 203384 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 400 | 7 | 1 | 5 | 3.5 | c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
| CHEMBL65367 | 203384 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 400 | 7 | 1 | 5 | 3.5 | c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
| 2543 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9805687 | |||
| 5358 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9805687 | |||
| 54 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9805687 | |||
| CHEMBL128 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9805687 | |||
| DB00669 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9805687 | |||
| 10789334 | 165341 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 442 | 8 | 1 | 5 | 3.7 | CC(=O)N(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9805687 | |||
| CHEMBL423599 | 165341 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 442 | 8 | 1 | 5 | 3.7 | CC(=O)N(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9805687 | |||
| 10621021 | 203384 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 400 | 7 | 1 | 5 | 3.5 | c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm981133m | |||
| CHEMBL65367 | 203384 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 400 | 7 | 1 | 5 | 3.5 | c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm981133m | |||
| 2543 | 3707 | 68 | None | -17 | 32 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | nan | |||
| 5358 | 3707 | 68 | None | -17 | 32 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | nan | |||
| 54 | 3707 | 68 | None | -17 | 32 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | nan | |||
| CHEMBL128 | 3707 | 68 | None | -17 | 32 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | nan | |||
| DB00669 | 3707 | 68 | None | -17 | 32 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | nan | |||
| 10646958 | 11407 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 444 | 9 | 3 | 6 | 3.5 | OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL118012 | 11407 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 444 | 9 | 3 | 6 | 3.5 | OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| 10787241 | 54592 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 401 | 8 | 2 | 6 | 2.8 | c1cc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)ccn1 | 10.1021/jm9805687 | |||
| CHEMBL161066 | 54592 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 401 | 8 | 2 | 6 | 2.8 | c1cc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)ccn1 | 10.1021/jm9805687 | |||
| 10788620 | 40047 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 427 | 8 | 2 | 4 | 5.1 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4ccnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL147907 | 40047 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 427 | 8 | 2 | 4 | 5.1 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4ccnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| 10131112 | 1552 | 25 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 246 | 1 | 2 | 1 | 3.5 | Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C | 10.1016/j.bmcl.2005.06.067 | |||
| 8428 | 1552 | 25 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 246 | 1 | 2 | 1 | 3.5 | Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C | 10.1016/j.bmcl.2005.06.067 | |||
| CHEMBL364005 | 1552 | 25 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 246 | 1 | 2 | 1 | 3.5 | Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C | 10.1016/j.bmcl.2005.06.067 | |||
| 15951404 | 125389 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 308 | 3 | 2 | 3 | 3.2 | CN1CCC(c2c[nH]c3ccc(/N=C(\N)c4ccco4)cc23)C1 | nan | |||
| CHEMBL3645480 | 125389 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 308 | 3 | 2 | 3 | 3.2 | CN1CCC(c2c[nH]c3ccc(/N=C(\N)c4ccco4)cc23)C1 | nan | |||
| 10635163 | 164927 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 261 | 3 | 0 | 3 | 2.9 | CCCN1CCCC12COc1cccc(OC)c1C2 | 10.1021/jm950861w | |||
| CHEMBL422453 | 164927 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 261 | 3 | 0 | 3 | 2.9 | CCCN1CCCC12COc1cccc(OC)c1C2 | 10.1021/jm950861w | |||
| 18366015 | 78372 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 313 | 4 | 2 | 3 | 2.6 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1 | 10.1021/jm000956k | |||
| CHEMBL2110300 | 78372 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 313 | 4 | 2 | 3 | 2.6 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1 | 10.1021/jm000956k | |||
| 10550367 | 115207 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 4.2 | COc1cccc2c1CC1(CCCCN1CCCCNC(=O)c1ccc(F)cc1)CO2 | 10.1021/jm950861w | |||
| CHEMBL334498 | 115207 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 4.2 | COc1cccc2c1CC1(CCCCN1CCCCNC(=O)c1ccc(F)cc1)CO2 | 10.1021/jm950861w | |||
| 10664878 | 89270 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 340 | 4 | 3 | 3 | 2.2 | CC1(C)NC(=O)N(CCc2ccc3[nH]cc([C@H]4C[C@H](N)C4)c3c2)C1=O | 10.1021/jm000956k | |||
| CHEMBL2368255 | 89270 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 340 | 4 | 3 | 3 | 2.2 | CC1(C)NC(=O)N(CCc2ccc3[nH]cc([C@H]4C[C@H](N)C4)c3c2)C1=O | 10.1021/jm000956k | |||
| 10516340 | 203466 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 272 | 1 | 0 | 5 | 2.3 | CN1CCN(c2nc3ccsc3n3cccc23)CC1 | 10.1021/jm950543x | |||
| CHEMBL65974 | 203466 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 272 | 1 | 0 | 5 | 2.3 | CN1CCN(c2nc3ccsc3n3cccc23)CC1 | 10.1021/jm950543x | |||
| 10529106 | 98314 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 490 | 5 | 3 | 5 | 3.4 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(C(N)=O)cc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
| CHEMBL274922 | 98314 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 490 | 5 | 3 | 5 | 3.4 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(C(N)=O)cc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
| 10646958 | 11407 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 444 | 9 | 3 | 6 | 3.5 | OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9704558 | |||
| CHEMBL118012 | 11407 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 444 | 9 | 3 | 6 | 3.5 | OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9704558 | |||
| 5 | 139 | 72 | None | -11 | 54 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2013.03.016 | |||
| 5202 | 139 | 72 | None | -11 | 54 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2013.03.016 | |||
| CHEMBL39 | 139 | 72 | None | -11 | 54 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2013.03.016 | |||
| DB08839 | 139 | 72 | None | -11 | 54 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2013.03.016 | |||
| 73356443 | 89701 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 294 | 2 | 2 | 2 | 4.6 | Cc1[nH]c2ccc(-c3ccsc3)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
| CHEMBL2376490 | 89701 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 294 | 2 | 2 | 2 | 4.6 | Cc1[nH]c2ccc(-c3ccsc3)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
| 11794750 | 119904 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 390 | 8 | 2 | 6 | 3.0 | c1cc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)co1 | 10.1021/jm9805687 | |||
| CHEMBL349185 | 119904 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 390 | 8 | 2 | 6 | 3.0 | c1cc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)co1 | 10.1021/jm9805687 | |||
| 10838684 | 119140 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 487 | 10 | 3 | 7 | 3.6 | NC(=O)OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL342805 | 119140 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 487 | 10 | 3 | 7 | 3.6 | NC(=O)OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| 10814424 | 99004 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 475 | 6 | 2 | 4 | 4.8 | COc1ccc(NC(=O)N2CCC(CCc3c[nH]c4ccccc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
| CHEMBL280000 | 99004 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 475 | 6 | 2 | 4 | 4.8 | COc1ccc(NC(=O)N2CCC(CCc3c[nH]c4ccccc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
| 10574762 | 10143 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
| CHEMBL115750 | 10143 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
| 10597901 | 10653 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 414 | 8 | 2 | 5 | 3.9 | c1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
| CHEMBL117046 | 10653 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 414 | 8 | 2 | 5 | 3.9 | c1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
| 10574762 | 10143 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9704560 | |||
| CHEMBL115750 | 10143 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9704560 | |||
| 10601144 | 119388 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 490 | 11 | 2 | 6 | 4.3 | COC[C@H](NC1CCN(CCCc2c[nH]c3ccc(Cn4cncn4)cc23)CC1)c1ccc(F)cc1 | 10.1021/jm9910021 | |||
| CHEMBL344537 | 119388 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 490 | 11 | 2 | 6 | 4.3 | COC[C@H](NC1CCN(CCCc2c[nH]c3ccc(Cn4cncn4)cc23)CC1)c1ccc(F)cc1 | 10.1021/jm9910021 | |||
| 9803620 | 162460 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 446 | 8 | 1 | 5 | 4.2 | CN(Cc1ccccc1)C1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
| CHEMBL416688 | 162460 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 446 | 8 | 1 | 5 | 4.2 | CN(Cc1ccccc1)C1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
| 10575553 | 203039 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 450 | 8 | 1 | 5 | 3.6 | Fc1cccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | |||
| CHEMBL63432 | 203039 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 450 | 8 | 1 | 5 | 3.6 | Fc1cccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | |||
| 10714071 | 89277 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 368 | 5 | 2 | 3 | 2.8 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CCN4C(=O)NC(C)(C)C4=O)cc32)C1 | 10.1021/jm000956k | |||
| CHEMBL2368262 | 89277 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 368 | 5 | 2 | 3 | 2.8 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CCN4C(=O)NC(C)(C)C4=O)cc32)C1 | 10.1021/jm000956k | |||
| 10597901 | 10653 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 414 | 8 | 2 | 5 | 3.9 | c1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9704558 | |||
| CHEMBL117046 | 10653 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 414 | 8 | 2 | 5 | 3.9 | c1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9704558 | |||
| 10740531 | 119866 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 414 | 9 | 2 | 5 | 3.4 | c1ccc(CCNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
| CHEMBL348815 | 119866 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 414 | 9 | 2 | 5 | 3.4 | c1ccc(CCNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
| 2477 | 745 | 59 | None | -16 | 29 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00401a007 | |||
| 36 | 745 | 59 | None | -16 | 29 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00401a007 | |||
| 437 | 745 | 59 | None | -16 | 29 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00401a007 | |||
| CHEMBL49 | 745 | 59 | None | -16 | 29 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00401a007 | |||
| DB00490 | 745 | 59 | None | -16 | 29 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00401a007 | |||
| 10617292 | 194709 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 342 | 3 | 0 | 4 | 3.8 | c1ccc(CN2CCN(c3nc4ccccc4n4cccc34)CC2)cc1 | 10.1021/jm960501o | |||
| CHEMBL53416 | 194709 | 0 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 342 | 3 | 0 | 4 | 3.8 | c1ccc(CN2CCN(c3nc4ccccc4n4cccc34)CC2)cc1 | 10.1021/jm960501o | |||
| 2585 | 803 | 103 | None | -100 | 21 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | nan | |||
| 522 | 803 | 103 | None | -100 | 21 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | nan | |||
| 551 | 803 | 103 | None | -100 | 21 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | nan | |||
| CHEMBL723 | 803 | 103 | None | -100 | 21 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | nan | |||
| DB01136 | 803 | 103 | None | -100 | 21 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | nan | |||
| 10667886 | 56015 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 386 | 6 | 1 | 5 | 3.5 | c1ccc(N2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
| CHEMBL162463 | 56015 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 386 | 6 | 1 | 5 | 3.5 | c1ccc(N2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
| 44214559 | 56498 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 443 | 8 | 2 | 6 | 2.5 | NC(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
| CHEMBL163462 | 56498 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 443 | 8 | 2 | 6 | 2.5 | NC(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
| 10573843 | 120147 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 414 | 7 | 1 | 5 | 4.1 | CC(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
| CHEMBL351346 | 120147 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 414 | 7 | 1 | 5 | 4.1 | CC(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
| 10504600 | 39948 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 471 | 10 | 2 | 6 | 4.0 | CN(C)C[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL147818 | 39948 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 471 | 10 | 2 | 6 | 4.0 | CN(C)C[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| 71459969 | 79530 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 446 | 8 | 1 | 5 | 4.2 | CN(Cc1ccccc1)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]1F | 10.1021/jm981133m | |||
| CHEMBL2114040 | 79530 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 446 | 8 | 1 | 5 | 4.2 | CN(Cc1ccccc1)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]1F | 10.1021/jm981133m | |||
| 15226949 | 102027 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 258 | 1 | 1 | 5 | 2.0 | c1cc2c(N3CCNCC3)nc3ccsc3n2c1 | 10.1021/jm950543x | |||
| CHEMBL301765 | 102027 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 258 | 1 | 1 | 5 | 2.0 | c1cc2c(N3CCNCC3)nc3ccsc3n2c1 | 10.1021/jm950543x | |||
| 15226949 | 102027 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 258 | 1 | 1 | 5 | 2.0 | c1cc2c(N3CCNCC3)nc3ccsc3n2c1 | 10.1021/jm960501o | |||
| CHEMBL301765 | 102027 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 258 | 1 | 1 | 5 | 2.0 | c1cc2c(N3CCNCC3)nc3ccsc3n2c1 | 10.1021/jm960501o | |||
| 10764869 | 119737 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 425 | 7 | 1 | 6 | 3.4 | N#Cc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
| CHEMBL347665 | 119737 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 425 | 7 | 1 | 6 | 3.4 | N#Cc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
| 9911120 | 9623 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 440 | 6 | 0 | 5 | 4.0 | COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1021/jm950861w | |||
| CHEMBL11265 | 9623 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 440 | 6 | 0 | 5 | 4.0 | COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1021/jm950861w | |||
| 10837591 | 118761 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 458 | 10 | 3 | 6 | 3.5 | OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(Cn4cncn4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL341854 | 118761 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 458 | 10 | 3 | 6 | 3.5 | OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(Cn4cncn4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| 10694177 | 203108 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 435 | 7 | 1 | 4 | 4.9 | FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm981133m | |||
| CHEMBL64003 | 203108 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 435 | 7 | 1 | 4 | 4.9 | FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm981133m | |||
| 9841032 | 194737 | 1 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 343 | 3 | 0 | 5 | 3.2 | c1ccc(CN2CCN(c3nc4cccnc4n4cccc34)CC2)cc1 | 10.1021/jm960501o | |||
| CHEMBL53573 | 194737 | 1 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 343 | 3 | 0 | 5 | 3.2 | c1ccc(CN2CCN(c3nc4cccnc4n4cccc34)CC2)cc1 | 10.1021/jm960501o | |||
| 14450355 | 119968 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 259 | 3 | 0 | 3 | 3.0 | CCCN1CCC=C2c3c(OC)cccc3OCC21 | 10.1021/jm00123a039 | |||
| CHEMBL349824 | 119968 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 259 | 3 | 0 | 3 | 3.0 | CCCN1CCC=C2c3c(OC)cccc3OCC21 | 10.1021/jm00123a039 | |||
| 10696635 | 98909 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 497 | 10 | 3 | 5 | 4.3 | COc1ccc(NC(=O)NCCN2CCC(c3c[nH]c4cc(F)ccc34)CC2)cc1OCCN(C)C | 10.1021/jm9811054 | |||
| CHEMBL279320 | 98909 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 497 | 10 | 3 | 5 | 4.3 | COc1ccc(NC(=O)NCCN2CCC(c3c[nH]c4cc(F)ccc34)CC2)cc1OCCN(C)C | 10.1021/jm9811054 | |||
| 10612178 | 119865 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 271 | 4 | 2 | 2 | 2.0 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC(N)=O)cc32)C1 | 10.1021/jm000956k | |||
| CHEMBL348811 | 119865 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 271 | 4 | 2 | 2 | 2.0 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC(N)=O)cc32)C1 | 10.1021/jm000956k | |||
| 3823 | 50221 | 42 | None | -38 | 10 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 530 | 7 | 0 | 7 | 4.2 | CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | nan | |||
| 76973198 | 50221 | 42 | None | -38 | 10 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 530 | 7 | 0 | 7 | 4.2 | CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | nan | |||
| CHEMBL157101 | 50221 | 42 | None | -38 | 10 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 530 | 7 | 0 | 7 | 4.2 | CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | nan | |||
| 213 | 3853 | 55 | None | -6 | 44 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | nan | |||
| 2717 | 3853 | 55 | None | -6 | 44 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | nan | |||
| 5533 | 3853 | 55 | None | -6 | 44 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | nan | |||
| CHEMBL621 | 3853 | 55 | None | -6 | 44 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | nan | |||
| DB00656 | 3853 | 55 | None | -6 | 44 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | nan | |||
| 2247 | 505 | 81 | None | -35 | 42 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | |||
| 249 | 505 | 81 | None | -35 | 42 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | |||
| 2603 | 505 | 81 | None | -35 | 42 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | |||
| CHEMBL296419 | 505 | 81 | None | -35 | 42 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | |||
| DB00637 | 505 | 81 | None | -35 | 42 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | |||
| 72548703 | 161567 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 583 | 8 | 3 | 6 | 5.8 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2018.03.093 | |||
| CHEMBL4128926 | 161567 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 583 | 8 | 3 | 6 | 5.8 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2018.03.093 | |||
| 10551206 | 119258 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 442 | 9 | 2 | 5 | 4.7 | C[C@@H](NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL343648 | 119258 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 442 | 9 | 2 | 5 | 4.7 | C[C@@H](NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| 10719687 | 202999 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 485 | 7 | 1 | 4 | 5.7 | FC1(Cc2ccccc2C(F)(F)F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
| CHEMBL63167 | 202999 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 485 | 7 | 1 | 4 | 5.7 | FC1(Cc2ccccc2C(F)(F)F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
| 110 | 1174 | 18 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 321 | 5 | 2 | 3 | 1.9 | CNS(=O)(=O)Cc1ccc2c(c1)c(c[nH]2)C[C@H]1CCCN1C | 10.1021/jm000956k | |||
| 132552 | 1174 | 18 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 321 | 5 | 2 | 3 | 1.9 | CNS(=O)(=O)Cc1ccc2c(c1)c(c[nH]2)C[C@H]1CCCN1C | 10.1021/jm000956k | |||
| CHEMBL159332 | 1174 | 18 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 321 | 5 | 2 | 3 | 1.9 | CNS(=O)(=O)Cc1ccc2c(c1)c(c[nH]2)C[C@H]1CCCN1C | 10.1021/jm000956k | |||
| 10718714 | 38142 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 458 | 10 | 3 | 6 | 3.3 | OC[C@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| CHEMBL146131 | 38142 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 458 | 10 | 3 | 6 | 3.3 | OC[C@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| 73351905 | 89702 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 288 | 2 | 2 | 1 | 4.5 | Cc1[nH]c2ccc(-c3ccccc3)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
| CHEMBL2376491 | 89702 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 288 | 2 | 2 | 1 | 4.5 | Cc1[nH]c2ccc(-c3ccccc3)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
| 10835665 | 38891 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 415 | 8 | 2 | 6 | 3.3 | c1cc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)ccn1 | 10.1021/jm9910021 | |||
| CHEMBL146729 | 38891 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 415 | 8 | 2 | 6 | 3.3 | c1cc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)ccn1 | 10.1021/jm9910021 | |||
| 10549785 | 39085 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 415 | 8 | 2 | 6 | 3.3 | c1cncc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm9910021 | |||
| CHEMBL146891 | 39085 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 415 | 8 | 2 | 6 | 3.3 | c1cncc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm9910021 | |||
| 10625408 | 39720 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 506 | 9 | 1 | 7 | 3.7 | CN(Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| CHEMBL147555 | 39720 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 506 | 9 | 1 | 7 | 3.7 | CN(Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| 10766277 | 40537 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 457 | 7 | 2 | 5 | 4.3 | CN(C(=O)Nc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| CHEMBL148325 | 40537 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 457 | 7 | 2 | 5 | 4.3 | CN(C(=O)Nc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| 11796806 | 102717 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 428 | 8 | 1 | 5 | 4.3 | CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| CHEMBL304857 | 102717 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 428 | 8 | 1 | 5 | 4.3 | CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| 10717709 | 165282 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 434 | 8 | 1 | 6 | 4.3 | CN(Cc1cccs1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| CHEMBL423212 | 165282 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 434 | 8 | 1 | 6 | 4.3 | CN(Cc1cccs1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| 11796806 | 102717 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 428 | 8 | 1 | 5 | 4.3 | CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
| CHEMBL304857 | 102717 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 428 | 8 | 1 | 5 | 4.3 | CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
| 10504100 | 47740 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 458 | 7 | 1 | 8 | 4.2 | COc1ccccc1C1CCN(CCCSc2nc3sc(C)c(C)c3c(=O)n2N)CC1 | 10.1021/jm950866t | |||
| CHEMBL154787 | 47740 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 458 | 7 | 1 | 8 | 4.2 | COc1ccccc1C1CCN(CCCSc2nc3sc(C)c(C)c3c(=O)n2N)CC1 | 10.1021/jm950866t | |||
| 10592324 | 103462 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 327 | 5 | 2 | 3 | 2.7 | CN(C)[C@H]1C[C@H](Cc2c[nH]c3ccc(C[C@H]4COC(=O)N4)cc23)C1 | 10.1021/jm000956k | |||
| CHEMBL3084967 | 103462 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 327 | 5 | 2 | 3 | 2.7 | CN(C)[C@H]1C[C@H](Cc2c[nH]c3ccc(C[C@H]4COC(=O)N4)cc23)C1 | 10.1021/jm000956k | |||
| 11793287 | 163277 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 366 | 3 | 0 | 5 | 4.0 | Fc1ccc(CN2CCN(c3nc4ccsc4n4cccc34)CC2)cc1 | 10.1021/jm950543x | |||
| CHEMBL418678 | 163277 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 366 | 3 | 0 | 5 | 4.0 | Fc1ccc(CN2CCN(c3nc4ccsc4n4cccc34)CC2)cc1 | 10.1021/jm950543x | |||
| 19978059 | 162447 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 420 | 3 | 0 | 6 | 4.2 | Clc1ccc2c(c1)nc(N1CCN(Cc3ccc4c(c3)OCO4)CC1)c1cccn12 | 10.1021/jm960501o | |||
| CHEMBL416662 | 162447 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 420 | 3 | 0 | 6 | 4.2 | Clc1ccc2c(c1)nc(N1CCN(Cc3ccc4c(c3)OCO4)CC1)c1cccn12 | 10.1021/jm960501o | |||
| 11796806 | 102717 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 428 | 8 | 1 | 5 | 4.3 | CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9704558 | |||
| CHEMBL304857 | 102717 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 428 | 8 | 1 | 5 | 4.3 | CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9704558 | |||
| 10614907 | 98185 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 310 | 5 | 2 | 5 | 1.6 | c1cc2[nH]cc(CCCN3CCNCC3)c2cc1-n1cnnc1 | 10.1021/jm980569z | |||
| CHEMBL274001 | 98185 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 310 | 5 | 2 | 5 | 1.6 | c1cc2[nH]cc(CCCN3CCNCC3)c2cc1-n1cnnc1 | 10.1021/jm980569z | |||
| 9930155 | 164032 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 387 | 7 | 1 | 5 | 3.6 | c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
| CHEMBL420874 | 164032 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 387 | 7 | 1 | 5 | 3.6 | c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
| 9930155 | 164032 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 387 | 7 | 1 | 5 | 3.6 | c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9704558 | |||
| CHEMBL420874 | 164032 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 387 | 7 | 1 | 5 | 3.6 | c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9704558 | |||
| 11792032 | 202821 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 348 | 2 | 0 | 5 | 4.0 | CN1CCN(c2nc3cc(-c4ccccc4)sc3n3cccc23)CC1 | 10.1021/jm950543x | |||
| CHEMBL62366 | 202821 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 348 | 2 | 0 | 5 | 4.0 | CN1CCN(c2nc3cc(-c4ccccc4)sc3n3cccc23)CC1 | 10.1021/jm950543x | |||
| 10733696 | 113328 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 309 | 5 | 1 | 4 | 3.2 | c1cc2[nH]cc(CCCN3CCCCC3)c2cc1-n1cnnc1 | 10.1021/jm9704558 | |||
| CHEMBL331612 | 113328 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 309 | 5 | 1 | 4 | 3.2 | c1cc2[nH]cc(CCCN3CCCCC3)c2cc1-n1cnnc1 | 10.1021/jm9704558 | |||
| 150 | 2509 | 21 | None | -6 | 16 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | nan | |||
| 1764 | 2509 | 21 | None | -6 | 16 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | nan | |||
| 8226 | 2509 | 21 | None | -6 | 16 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | nan | |||
| CHEMBL1201356 | 2509 | 21 | None | -6 | 16 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | nan | |||
| DB00353 | 2509 | 21 | None | -6 | 16 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | nan | |||
| 9844873 | 101058 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 417 | 7 | 1 | 4 | 4.7 | FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/acs.jmedchem.5b00258 | |||
| CHEMBL294732 | 101058 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 417 | 7 | 1 | 4 | 4.7 | FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/acs.jmedchem.5b00258 | |||
| 10733696 | 113328 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 309 | 5 | 1 | 4 | 3.2 | c1cc2[nH]cc(CCCN3CCCCC3)c2cc1-n1cnnc1 | 10.1021/jm980569z | |||
| CHEMBL331612 | 113328 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 309 | 5 | 1 | 4 | 3.2 | c1cc2[nH]cc(CCCN3CCCCC3)c2cc1-n1cnnc1 | 10.1021/jm980569z | |||
| 10597902 | 53000 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 414 | 8 | 1 | 5 | 3.9 | CN(Cc1ccccc1)C[C@@H]1CCCN1CCc1c[nH]c2ccc(-n3cnnc3)cc12 | 10.1021/jm9805687 | |||
| CHEMBL159683 | 53000 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 414 | 8 | 1 | 5 | 3.9 | CN(Cc1ccccc1)C[C@@H]1CCCN1CCc1c[nH]c2ccc(-n3cnnc3)cc12 | 10.1021/jm9805687 | |||
| 9844873 | 101058 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 417 | 7 | 1 | 4 | 4.7 | FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
| CHEMBL294732 | 101058 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 417 | 7 | 1 | 4 | 4.7 | FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
| 11 | 1187 | 19 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 215 | 1 | 3 | 2 | 1.2 | O=c1ccc2c([nH]1)c(c[nH]2)C1=CCNCC1 | 10.1021/jm00170a007 | |||
| 124007 | 1187 | 19 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 215 | 1 | 3 | 2 | 1.2 | O=c1ccc2c([nH]1)c(c[nH]2)C1=CCNCC1 | 10.1021/jm00170a007 | |||
| CHEMBL304008 | 1187 | 19 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 215 | 1 | 3 | 2 | 1.2 | O=c1ccc2c([nH]1)c(c[nH]2)C1=CCNCC1 | 10.1021/jm00170a007 | |||
| 10766319 | 38758 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 458 | 10 | 3 | 6 | 3.9 | OCCC(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL146628 | 38758 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 458 | 10 | 3 | 6 | 3.9 | OCCC(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| 16 | 2253 | 8 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 462 | 9 | 3 | 6 | 3.6 | OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9910021 | |||
| 9847194 | 2253 | 8 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 462 | 9 | 3 | 6 | 3.6 | OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9910021 | |||
| CHEMBL313714 | 2253 | 8 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 462 | 9 | 3 | 6 | 3.6 | OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9910021 | |||
| 10813769 | 120989 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 458 | 9 | 3 | 6 | 3.9 | C[C@H](O)[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL356315 | 120989 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 458 | 9 | 3 | 6 | 3.9 | C[C@H](O)[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| 109 | 902 | 31 | None | - | 7 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 334 | 1 | 0 | 4 | 3.3 | CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F | 10.1021/jm00170a007 | |||
| 2689 | 902 | 31 | None | - | 7 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 334 | 1 | 0 | 4 | 3.3 | CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F | 10.1021/jm00170a007 | |||
| CHEMBL27403 | 902 | 31 | None | - | 7 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 334 | 1 | 0 | 4 | 3.3 | CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F | 10.1021/jm00170a007 | |||
| 10753377 | 194723 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 253 | 1 | 1 | 5 | 1.3 | c1cnc2c(c1)nc(N1CCNCC1)c1cccn12 | 10.1021/jm960501o | |||
| CHEMBL53490 | 194723 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 253 | 1 | 1 | 5 | 1.3 | c1cnc2c(c1)nc(N1CCNCC1)c1cccn12 | 10.1021/jm960501o | |||
| 10757342 | 55107 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 310 | 4 | 1 | 4 | 3.3 | Cc1noc(Cc2ccc3[nH]cc([C@H]4C[C@H](N(C)C)C4)c3c2)n1 | 10.1021/jm000956k | |||
| CHEMBL161694 | 55107 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 310 | 4 | 1 | 4 | 3.3 | Cc1noc(Cc2ccc3[nH]cc([C@H]4C[C@H](N(C)C)C4)c3c2)n1 | 10.1021/jm000956k | |||
| 44267168 | 9855 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 497 | 8 | 0 | 6 | 3.9 | CCCN1CCN(CCCCN2C(=O)CC3(CCCC3)CC2=O)CC12COc1cccc(OC)c1C2 | 10.1016/0960-894X(96)00174-6 | |||
| CHEMBL11409 | 9855 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 497 | 8 | 0 | 6 | 3.9 | CCCN1CCN(CCCCN2C(=O)CC3(CCCC3)CC2=O)CC12COc1cccc(OC)c1C2 | 10.1016/0960-894X(96)00174-6 | |||
| 2543 | 3707 | 68 | None | -3 | 32 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704558 | |||
| 5358 | 3707 | 68 | None | -3 | 32 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704558 | |||
| 54 | 3707 | 68 | None | -3 | 32 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704558 | |||
| CHEMBL128 | 3707 | 68 | None | -3 | 32 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704558 | |||
| DB00669 | 3707 | 68 | None | -3 | 32 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704558 | |||
| 2543 | 3707 | 68 | None | -3 | 32 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704560 | |||
| 5358 | 3707 | 68 | None | -3 | 32 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704560 | |||
| 54 | 3707 | 68 | None | -3 | 32 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704560 | |||
| CHEMBL128 | 3707 | 68 | None | -3 | 32 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704560 | |||
| DB00669 | 3707 | 68 | None | -3 | 32 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704560 | |||
| 10813413 | 203681 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 449 | 8 | 1 | 4 | 5.3 | Fc1ccccc1CCC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
| CHEMBL67460 | 203681 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 449 | 8 | 1 | 4 | 5.3 | Fc1ccccc1CCC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
| 5 | 139 | 72 | None | -11 | 54 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm701575k | |||
| 5202 | 139 | 72 | None | -11 | 54 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm701575k | |||
| CHEMBL39 | 139 | 72 | None | -11 | 54 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm701575k | |||
| DB08839 | 139 | 72 | None | -11 | 54 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm701575k | |||
| 15951194 | 71638 | 12 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 336 | 3 | 2 | 3 | 4.0 | CN1CC=C(c2c[nH]c3ccc(/N=C(\N)c4cccs4)cc23)CC1 | nan | |||
| CHEMBL1963527 | 71638 | 12 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 336 | 3 | 2 | 3 | 4.0 | CN1CC=C(c2c[nH]c3ccc(/N=C(\N)c4cccs4)cc23)CC1 | nan | |||
| 11797562 | 38143 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 444 | 9 | 3 | 6 | 3.5 | OC[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL146132 | 38143 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 444 | 9 | 3 | 6 | 3.5 | OC[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| 10695596 | 102793 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 468 | 8 | 1 | 5 | 3.9 | Fc1cccc(CCN2CCN(CC(F)(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | |||
| CHEMBL305301 | 102793 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 468 | 8 | 1 | 5 | 3.9 | Fc1cccc(CCN2CCN(CC(F)(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | |||
| 18366015 | 78372 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 313 | 4 | 2 | 3 | 2.6 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1 | 10.1021/jm000956k | |||
| CHEMBL2110300 | 78372 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 313 | 4 | 2 | 3 | 2.6 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1 | 10.1021/jm000956k | |||
| 10718668 | 119919 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 457 | 9 | 3 | 6 | 3.4 | CC(=O)Nc1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
| CHEMBL349390 | 119919 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 457 | 9 | 3 | 6 | 3.4 | CC(=O)Nc1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
| 10502763 | 120142 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 430 | 9 | 3 | 6 | 2.9 | OC[C@@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
| CHEMBL351303 | 120142 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 430 | 9 | 3 | 6 | 2.9 | OC[C@@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
| 10645471 | 11042 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 414 | 8 | 1 | 5 | 3.5 | c1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
| CHEMBL117633 | 11042 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 414 | 8 | 1 | 5 | 3.5 | c1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
| 10516184 | 14529 | 4 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 270 | 1 | 1 | 4 | 2.0 | Fc1ccc2c(c1)nc(N1CCNCC1)c1cccn12 | 10.1021/jm970376w | |||
| CHEMBL120216 | 14529 | 4 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 270 | 1 | 1 | 4 | 2.0 | Fc1ccc2c(c1)nc(N1CCNCC1)c1cccn12 | 10.1021/jm970376w | |||
| 10789399 | 119874 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 443 | 9 | 2 | 6 | 3.3 | CNCC(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
| CHEMBL348962 | 119874 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 443 | 9 | 2 | 6 | 3.3 | CNCC(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
| 10551207 | 38598 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 442 | 9 | 2 | 5 | 4.4 | C[C@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| CHEMBL146502 | 38598 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 442 | 9 | 2 | 5 | 4.4 | C[C@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| 10696275 | 38009 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 485 | 10 | 3 | 6 | 3.9 | CC(=O)Nc1ccc(CCNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
| CHEMBL146023 | 38009 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 485 | 10 | 3 | 6 | 3.9 | CC(=O)Nc1ccc(CCNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
| 10645471 | 11042 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 414 | 8 | 1 | 5 | 3.5 | c1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9704560 | |||
| CHEMBL117633 | 11042 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 414 | 8 | 1 | 5 | 3.5 | c1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9704560 | |||
| 10814273 | 114352 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 471 | 9 | 2 | 6 | 3.5 | CC(=O)Nc1cccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm9704560 | |||
| CHEMBL333089 | 114352 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 471 | 9 | 2 | 6 | 3.5 | CC(=O)Nc1cccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm9704560 | |||
| 67650695 | 79527 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 500 | 8 | 2 | 5 | 4.9 | F[C@H]1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC[C@@H]1NCc1ccccc1C(F)(F)F | 10.1021/jm981133m | |||
| CHEMBL2114038 | 79527 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 500 | 8 | 2 | 5 | 4.9 | F[C@H]1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC[C@@H]1NCc1ccccc1C(F)(F)F | 10.1021/jm981133m | |||
| 134 | 2514 | 24 | None | -251 | 67 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | nan | |||
| 1775 | 2514 | 24 | None | -251 | 67 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | nan | |||
| 9681 | 2514 | 24 | None | -251 | 67 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | nan | |||
| CHEMBL1065 | 2514 | 24 | None | -251 | 67 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | nan | |||
| DB00247 | 2514 | 24 | None | -251 | 67 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | nan | |||
| 2543 | 3707 | 68 | None | -17 | 32 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | nan | |||
| 5358 | 3707 | 68 | None | -17 | 32 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | nan | |||
| 54 | 3707 | 68 | None | -17 | 32 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | nan | |||
| CHEMBL128 | 3707 | 68 | None | -17 | 32 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | nan | |||
| DB00669 | 3707 | 68 | None | -17 | 32 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | nan | |||
| 10620429 | 56264 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 390 | 7 | 1 | 6 | 3.1 | c1coc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm980569z | |||
| CHEMBL162805 | 56264 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 390 | 7 | 1 | 6 | 3.1 | c1coc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm980569z | |||
| 10644750 | 56512 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 401 | 7 | 1 | 6 | 2.9 | c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1 | 10.1021/jm980569z | |||
| CHEMBL163573 | 56512 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 401 | 7 | 1 | 6 | 2.9 | c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1 | 10.1021/jm980569z | |||
| 10574671 | 120225 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 430 | 7 | 1 | 5 | 3.8 | S=C1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CCN1Cc1ccccc1 | 10.1021/jm980569z | |||
| CHEMBL352159 | 120225 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 430 | 7 | 1 | 5 | 3.8 | S=C1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CCN1Cc1ccccc1 | 10.1021/jm980569z | |||
| 10719938 | 37960 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 492 | 9 | 1 | 6 | 3.7 | CN(CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)S(=O)(=O)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL145982 | 37960 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 492 | 9 | 1 | 6 | 3.7 | CN(CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)S(=O)(=O)c1ccccc1 | 10.1021/jm9910021 | |||
| 18691541 | 78371 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 285 | 3 | 3 | 3 | 2.0 | N[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1 | 10.1021/jm000956k | |||
| CHEMBL2110299 | 78371 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 285 | 3 | 3 | 3 | 2.0 | N[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1 | 10.1021/jm000956k | |||
| 10809876 | 102653 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 381 | 5 | 0 | 5 | 2.4 | COc1ccccc1N1CCN(CCc2ccc3c(c2)OCC(=O)N3C)CC1 | 10.1021/jm970298c | |||
| CHEMBL304438 | 102653 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 381 | 5 | 0 | 5 | 2.4 | COc1ccccc1N1CCN(CCc2ccc3c(c2)OCC(=O)N3C)CC1 | 10.1021/jm970298c | |||
| 10131112 | 1552 | 25 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 246 | 1 | 2 | 1 | 3.5 | Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C | 10.1016/j.bmcl.2005.06.067 | |||
| 8428 | 1552 | 25 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 246 | 1 | 2 | 1 | 3.5 | Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C | 10.1016/j.bmcl.2005.06.067 | |||
| CHEMBL364005 | 1552 | 25 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 246 | 1 | 2 | 1 | 3.5 | Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C | 10.1016/j.bmcl.2005.06.067 | |||
| 10837853 | 168158 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 464 | 8 | 1 | 5 | 4.3 | CC(CN1CCN(CC(F)(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm981133m | |||
| CHEMBL433108 | 168158 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 464 | 8 | 1 | 5 | 4.3 | CC(CN1CCN(CC(F)(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm981133m | |||
| 7059581 | 167045 | 3 | None | - | 2 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2 | 10.1021/jm00401a007 | |||
| CHEMBL428892 | 167045 | 3 | None | - | 2 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2 | 10.1021/jm00401a007 | |||
| 16 | 2253 | 8 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 462 | 9 | 3 | 6 | 3.6 | OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9704558 | |||
| 9847194 | 2253 | 8 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 462 | 9 | 3 | 6 | 3.6 | OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9704558 | |||
| CHEMBL313714 | 2253 | 8 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 462 | 9 | 3 | 6 | 3.6 | OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9704558 | |||
| 2351 | 3286 | 64 | None | -10 | 21 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 473 | 7 | 2 | 6 | 6.1 | Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O | nan | |||
| 2820 | 3286 | 64 | None | -10 | 21 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 473 | 7 | 2 | 6 | 6.1 | Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O | nan | |||
| 5035 | 3286 | 64 | None | -10 | 21 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 473 | 7 | 2 | 6 | 6.1 | Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O | nan | |||
| CHEMBL81 | 3286 | 64 | None | -10 | 21 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 473 | 7 | 2 | 6 | 6.1 | Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O | nan | |||
| DB00481 | 3286 | 64 | None | -10 | 21 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 473 | 7 | 2 | 6 | 6.1 | Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O | nan | |||
| 10717512 | 203068 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 430 | 4 | 0 | 5 | 4.9 | FC(F)(F)c1ccccc1CCN1CCN(c2nc3ccsc3n3cccc23)CC1 | 10.1021/jm950543x | |||
| CHEMBL63713 | 203068 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 430 | 4 | 0 | 5 | 4.9 | FC(F)(F)c1ccccc1CCN1CCN(c2nc3ccsc3n3cccc23)CC1 | 10.1021/jm950543x | |||
| 15516682 | 10290 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 450 | 7 | 2 | 6 | 3.6 | CC1(C)CCCN(CC2(O)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)C1 | 10.1016/s0960-894x(99)00614-9 | |||
| CHEMBL116161 | 10290 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 450 | 7 | 2 | 6 | 3.6 | CC1(C)CCCN(CC2(O)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)C1 | 10.1016/s0960-894x(99)00614-9 | |||
| 133 | 2496 | 52 | None | -40 | 42 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | |||
| 1723 | 2496 | 52 | None | -40 | 42 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | |||
| 28693 | 2496 | 52 | None | -40 | 42 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | |||
| CHEMBL19215 | 2496 | 52 | None | -40 | 42 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | |||
| DB13520 | 2496 | 52 | None | -40 | 42 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | |||
| 18975369 | 101029 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 399 | 7 | 1 | 4 | 4.6 | c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/acs.jmedchem.5b00258 | |||
| CHEMBL294547 | 101029 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 399 | 7 | 1 | 4 | 4.6 | c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/acs.jmedchem.5b00258 | |||
| 18975369 | 101029 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 399 | 7 | 1 | 4 | 4.6 | c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm981133m | |||
| CHEMBL294547 | 101029 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 399 | 7 | 1 | 4 | 4.6 | c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm981133m | |||
| 10576618 | 202940 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 478 | 3 | 0 | 5 | 6.6 | FC(F)(F)c1cccc(N2CCN(c3nc4scc(-c5ccccc5)c4n4cccc34)CC2)c1 | 10.1021/jm950543x | |||
| CHEMBL62902 | 202940 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 478 | 3 | 0 | 5 | 6.6 | FC(F)(F)c1cccc(N2CCN(c3nc4scc(-c5ccccc5)c4n4cccc34)CC2)c1 | 10.1021/jm950543x | |||
| 10738329 | 101734 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 376 | 3 | 0 | 4 | 4.5 | Clc1ccc2c(c1)nc(N1CCN(Cc3ccccc3)CC1)c1cccn12 | 10.1021/jm960501o | |||
| CHEMBL299634 | 101734 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 376 | 3 | 0 | 4 | 4.5 | Clc1ccc2c(c1)nc(N1CCN(Cc3ccccc3)CC1)c1cccn12 | 10.1021/jm960501o | |||
| 1212 | 1662 | 50 | None | -144 | 65 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | |||
| 204 | 1662 | 50 | None | -144 | 65 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | |||
| 3372 | 1662 | 50 | None | -144 | 65 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | |||
| CHEMBL726 | 1662 | 50 | None | -144 | 65 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | |||
| DB00623 | 1662 | 50 | None | -144 | 65 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | |||
| 44305547 | 203330 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 380 | 4 | 0 | 5 | 4.0 | Fc1ccc(CN2CCN(Cc3nc4ccsc4n4cccc34)CC2)cc1 | 10.1021/jm950543x | |||
| CHEMBL64903 | 203330 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 380 | 4 | 0 | 5 | 4.0 | Fc1ccc(CN2CCN(Cc3nc4ccsc4n4cccc34)CC2)cc1 | 10.1021/jm950543x | |||
| 10569395 | 101648 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 343 | 3 | 0 | 5 | 3.3 | C=CCN1CCN(c2nc3ccc4ncccc4c3n3cccc23)CC1 | 10.1021/jm960501o | |||
| CHEMBL299097 | 101648 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 343 | 3 | 0 | 5 | 3.3 | C=CCN1CCN(c2nc3ccc4ncccc4c3n3cccc23)CC1 | 10.1021/jm960501o | |||
| 124 | 2981 | 47 | None | -2 | 33 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | nan | |||
| 2032 | 2981 | 47 | None | -2 | 33 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | nan | |||
| 4636 | 2981 | 47 | None | -2 | 33 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | nan | |||
| CHEMBL762 | 2981 | 47 | None | -2 | 33 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | nan | |||
| DB00935 | 2981 | 47 | None | -2 | 33 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | nan | |||
| 130 | 3500 | 47 | None | -8 | 13 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm990397l | |||
| 3378093 | 3500 | 47 | None | -8 | 13 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm990397l | |||
| CHEMBL281350 | 3500 | 47 | None | -8 | 13 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm990397l | |||
| 108029 | 3414 | 57 | None | -3 | 13 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 228 | 2 | 2 | 2 | 2.6 | COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1 | 10.1021/jm00170a007 | |||
| 23 | 3414 | 57 | None | -3 | 13 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 228 | 2 | 2 | 2 | 2.6 | COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1 | 10.1021/jm00170a007 | |||
| CHEMBL18785 | 3414 | 57 | None | -3 | 13 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 228 | 2 | 2 | 2 | 2.6 | COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1 | 10.1021/jm00170a007 | |||
| 10838923 | 52635 | 0 | None | - | 3 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 494 | 4 | 1 | 6 | 5.6 | Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc5c(c4)C4(CCN(C)CC4)CO5)cc3)c(C)c2)no1 | 10.1021/jm9811054 | |||
| CHEMBL15933 | 52635 | 0 | None | - | 3 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 494 | 4 | 1 | 6 | 5.6 | Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc5c(c4)C4(CCN(C)CC4)CO5)cc3)c(C)c2)no1 | 10.1021/jm9811054 | |||
| 11798094 | 54719 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 457 | 8 | 2 | 6 | 3.5 | CC(=O)Nc1cccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm980569z | |||
| CHEMBL161176 | 54719 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 457 | 8 | 2 | 6 | 3.5 | CC(=O)Nc1cccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm980569z | |||
| 10787240 | 119806 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 401 | 8 | 1 | 5 | 4.0 | c1ccc(COC[C@@H]2CCCN2CCc2c[nH]c3ccc(-n4cnnc4)cc23)cc1 | 10.1021/jm9805687 | |||
| CHEMBL348304 | 119806 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 401 | 8 | 1 | 5 | 4.0 | c1ccc(COC[C@@H]2CCCN2CCc2c[nH]c3ccc(-n4cnnc4)cc23)cc1 | 10.1021/jm9805687 | |||
| 1042 | 1581 | 23 | None | -5 | 17 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | nan | |||
| 148 | 1581 | 23 | None | -5 | 17 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | nan | |||
| 443884 | 1581 | 23 | None | -5 | 17 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | nan | |||
| CHEMBL119443 | 1581 | 23 | None | -5 | 17 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | nan | |||
| DB01253 | 1581 | 23 | None | -5 | 17 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | nan | |||
| 196129 | 67798 | 17 | None | -1 | 15 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 917 | 13 | 4 | 16 | 4.3 | CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC | nan | |||
| CHEMBL1909065 | 67798 | 17 | None | -1 | 15 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 917 | 13 | 4 | 16 | 4.3 | CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC | nan | |||
| 10547091 | 202098 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 369 | 5 | 1 | 6 | 3.4 | COc1ccccc1N1CCN(CCc2ccc3nc(O)sc3c2)CC1 | 10.1021/jm970298c | |||
| CHEMBL60885 | 202098 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 369 | 5 | 1 | 6 | 3.4 | COc1ccccc1N1CCN(CCc2ccc3nc(O)sc3c2)CC1 | 10.1021/jm970298c | |||
| 10716915 | 55145 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 418 | 7 | 1 | 5 | 3.6 | Fc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
| CHEMBL161723 | 55145 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 418 | 7 | 1 | 5 | 3.6 | Fc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
| 10572483 | 119887 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 390 | 8 | 2 | 6 | 3.0 | c1coc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)c1 | 10.1021/jm9805687 | |||
| CHEMBL349041 | 119887 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 390 | 8 | 2 | 6 | 3.0 | c1coc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)c1 | 10.1021/jm9805687 | |||
| 10522029 | 203149 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 353 | 4 | 0 | 5 | 3.0 | Cn1c(=O)sc2cc(CCN3CCN(c4ccccc4)CC3)ccc21 | 10.1021/jm970298c | |||
| CHEMBL64167 | 203149 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 353 | 4 | 0 | 5 | 3.0 | Cn1c(=O)sc2cc(CCN3CCN(c4ccccc4)CC3)ccc21 | 10.1021/jm970298c | |||
| 10524876 | 203325 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 397 | 7 | 1 | 6 | 4.2 | COc1ccccc1N1CCN(CCCCc2ccc3nc(O)sc3c2)CC1 | 10.1021/jm970298c | |||
| CHEMBL64878 | 203325 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 397 | 7 | 1 | 6 | 4.2 | COc1ccccc1N1CCN(CCCCc2ccc3nc(O)sc3c2)CC1 | 10.1021/jm970298c | |||
| 10504095 | 165261 | 1 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 458 | 9 | 3 | 6 | 3.9 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@H](O)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL423022 | 165261 | 1 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 458 | 9 | 3 | 6 | 3.9 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@H](O)c1ccccc1 | 10.1021/jm9910021 | |||
| 73347306 | 89694 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 230 | 1 | 2 | 1 | 3.0 | Cc1[nH]c2ccc(F)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
| CHEMBL2376483 | 89694 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 230 | 1 | 2 | 1 | 3.0 | Cc1[nH]c2ccc(F)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
| 10645715 | 40263 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 418 | 8 | 1 | 6 | 3.9 | CN(Cc1ccoc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| CHEMBL148085 | 40263 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 418 | 8 | 1 | 6 | 3.9 | CN(Cc1ccoc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| 9980269 | 99083 | 0 | None | - | 1 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 432 | 10 | 1 | 5 | 3.4 | CCCN(CCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL280586 | 99083 | 0 | None | - | 1 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 432 | 10 | 1 | 5 | 3.4 | CCCN(CCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL54266 | 99083 | 0 | None | - | 1 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 432 | 10 | 1 | 5 | 3.4 | CCCN(CCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| 10251234 | 11245 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 414 | 9 | 0 | 5 | 3.3 | CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL1178932 | 11245 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 414 | 9 | 0 | 5 | 3.3 | CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL50530 | 11245 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 414 | 9 | 0 | 5 | 3.3 | CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| 9978353 | 11253 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 400 | 7 | 1 | 5 | 3.1 | COc1cccc2c1CC(NCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1021/jm00038a007 | |||
| CHEMBL1178987 | 11253 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 400 | 7 | 1 | 5 | 3.1 | COc1cccc2c1CC(NCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1021/jm00038a007 | |||
| CHEMBL52785 | 11253 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 400 | 7 | 1 | 5 | 3.1 | COc1cccc2c1CC(NCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1021/jm00038a007 | |||
| 10095594 | 12368 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 456 | 10 | 0 | 5 | 4.6 | CCCN(CCCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL1185501 | 12368 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 456 | 10 | 0 | 5 | 4.6 | CCCN(CCCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL417550 | 12368 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 456 | 10 | 0 | 5 | 4.6 | CCCN(CCCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| 9981024 | 96097 | 0 | None | - | 1 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 446 | 11 | 1 | 5 | 3.8 | CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL26018 | 96097 | 0 | None | - | 1 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 446 | 11 | 1 | 5 | 3.8 | CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL300735 | 96097 | 0 | None | - | 1 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 446 | 11 | 1 | 5 | 3.8 | CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| 10252000 | 98547 | 0 | None | - | 1 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 428 | 8 | 0 | 5 | 3.8 | CCCN(CCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL27650 | 98547 | 0 | None | - | 1 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 428 | 8 | 0 | 5 | 3.8 | CCCN(CCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL50188 | 98547 | 0 | None | - | 1 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 428 | 8 | 0 | 5 | 3.8 | CCCN(CCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| 3082597 | 99559 | 8 | None | - | 1 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 263 | 6 | 0 | 3 | 3.1 | CCCN(CCC)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL283606 | 99559 | 8 | None | - | 1 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 263 | 6 | 0 | 3 | 3.1 | CCCN(CCC)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| 3082597 | 99559 | 8 | None | - | 1 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 263 | 6 | 0 | 3 | 3.1 | CCCN(CCC)C1COc2cccc(OC)c2C1 | 10.1021/jm950861w | |||
| CHEMBL283606 | 99559 | 8 | None | - | 1 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 263 | 6 | 0 | 3 | 3.1 | CCCN(CCC)C1COc2cccc(OC)c2C1 | 10.1021/jm950861w | |||
| 18691565 | 89272 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 327 | 4 | 1 | 3 | 3.0 | CN1C(=O)OCC1Cc1ccc2[nH]cc([C@H]3C[C@H](N(C)C)C3)c2c1 | 10.1021/jm000956k | |||
| CHEMBL2368257 | 89272 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 327 | 4 | 1 | 3 | 3.0 | CN1C(=O)OCC1Cc1ccc2[nH]cc([C@H]3C[C@H](N(C)C)C3)c2c1 | 10.1021/jm000956k | |||
| 10643940 | 89276 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 387 | 5 | 1 | 3 | 3.8 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CCN4C(=O)c5ccccc5C4=O)cc32)C1 | 10.1021/jm000956k | |||
| CHEMBL2368261 | 89276 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 387 | 5 | 1 | 3 | 3.8 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CCN4C(=O)c5ccccc5C4=O)cc32)C1 | 10.1021/jm000956k | |||
| 10637485 | 101665 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 293 | 3 | 0 | 5 | 2.2 | C=CCN1CCN(c2nc3cccnc3n3cccc23)CC1 | 10.1021/jm960501o | |||
| CHEMBL299231 | 101665 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 293 | 3 | 0 | 5 | 2.2 | C=CCN1CCN(c2nc3cccnc3n3cccc23)CC1 | 10.1021/jm960501o | |||
| 4189 | 206922 | 96 | None | -41 | 34 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | |||
| CHEMBL1559 | 206922 | 96 | None | -41 | 34 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | |||
| CHEMBL91 | 206922 | 96 | None | -41 | 34 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | |||
| 10621020 | 110385 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 400 | 7 | 1 | 5 | 3.5 | CN(Cc1ccccc1)[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9805687 | |||
| CHEMBL324287 | 110385 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 400 | 7 | 1 | 5 | 3.5 | CN(Cc1ccccc1)[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9805687 | |||
| 10805623 | 99252 | 0 | None | - | 1 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 320 | 1 | 1 | 4 | 2.9 | FC(F)(F)c1ccc2c(c1)nc(N1CCNCC1)c1cccn12 | 10.1021/jm00170a007 | |||
| CHEMBL28178 | 99252 | 0 | None | - | 1 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 320 | 1 | 1 | 4 | 2.9 | FC(F)(F)c1ccc2c(c1)nc(N1CCNCC1)c1cccn12 | 10.1021/jm00170a007 | |||
| 10575878 | 35528 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 458 | 9 | 3 | 6 | 3.9 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@@H](O)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL143890 | 35528 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 458 | 9 | 3 | 6 | 3.9 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@@H](O)c1ccccc1 | 10.1021/jm9910021 | |||
| 10766318 | 37773 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 458 | 10 | 2 | 6 | 4.1 | COC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL145815 | 37773 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 458 | 10 | 2 | 6 | 4.1 | COC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| 10551857 | 165372 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 458 | 9 | 2 | 6 | 3.8 | CN(C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@@H](CO)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL423749 | 165372 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 458 | 9 | 2 | 6 | 3.8 | CN(C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@@H](CO)c1ccccc1 | 10.1021/jm9910021 | |||
| 10621020 | 110385 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 400 | 7 | 1 | 5 | 3.5 | CN(Cc1ccccc1)[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9704558 | |||
| CHEMBL324287 | 110385 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 400 | 7 | 1 | 5 | 3.5 | CN(Cc1ccccc1)[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9704558 | |||
| 10766235 | 78860 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 456 | 7 | 3 | 6 | 3.4 | O[C@@H]1Cc2ccccc2[C@H]1NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| CHEMBL2112862 | 78860 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 456 | 7 | 3 | 6 | 3.4 | O[C@@H]1Cc2ccccc2[C@H]1NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| 10624003 | 203663 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 464 | 8 | 1 | 5 | 4.5 | CN(Cc1ccccc1)C1CCN(CC(F)(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
| CHEMBL67367 | 203663 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 464 | 8 | 1 | 5 | 4.5 | CN(Cc1ccccc1)C1CCN(CC(F)(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
| 135398737 | 958 | 93 | None | -691 | 89 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | |||
| 38 | 958 | 93 | None | -691 | 89 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | |||
| 722 | 958 | 93 | None | -691 | 89 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | |||
| CHEMBL42 | 958 | 93 | None | -691 | 89 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | |||
| DB00363 | 958 | 93 | None | -691 | 89 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | |||
| 146420029 | 184762 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 379 | 3 | 1 | 3 | 4.2 | CN1CCC(=C(F)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1 | 10.1016/j.ejmech.2021.113782 | |||
| CHEMBL4851044 | 184762 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 379 | 3 | 1 | 3 | 4.2 | CN1CCC(=C(F)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1 | 10.1016/j.ejmech.2021.113782 | |||
| 10834909 | 164920 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 401 | 7 | 1 | 6 | 2.9 | c1cncc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm980569z | |||
| CHEMBL422366 | 164920 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 401 | 7 | 1 | 6 | 2.9 | c1cncc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm980569z | |||
| 10503687 | 203077 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 449 | 8 | 1 | 4 | 5.3 | Fc1cccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | |||
| CHEMBL63799 | 203077 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 449 | 8 | 1 | 4 | 5.3 | Fc1cccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | |||
| 67650716 | 79528 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 514 | 8 | 1 | 5 | 5.2 | CN(Cc1ccccc1C(F)(F)F)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]1F | 10.1021/jm981133m | |||
| CHEMBL2114039 | 79528 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 514 | 8 | 1 | 5 | 5.2 | CN(Cc1ccccc1C(F)(F)F)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]1F | 10.1021/jm981133m | |||
| 71450983 | 79649 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 514 | 8 | 1 | 5 | 5.2 | CN(Cc1ccccc1C(F)(F)F)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@H]1F | 10.1021/jm981133m | |||
| CHEMBL2115112 | 79649 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 514 | 8 | 1 | 5 | 5.2 | CN(Cc1ccccc1C(F)(F)F)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@H]1F | 10.1021/jm981133m | |||
| 44323506 | 207022 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 446 | 8 | 1 | 5 | 4.2 | CN(Cc1ccccc1)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@H]1F | 10.1021/jm981133m | |||
| CHEMBL91534 | 207022 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 446 | 8 | 1 | 5 | 4.2 | CN(Cc1ccccc1)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@H]1F | 10.1021/jm981133m | |||
| 25014630 | 83539 | 1 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 326 | 3 | 3 | 4 | 3.3 | N=C(Nc1ccc2c(c1)CCN2C1CCNCC1)c1cccs1 | 10.1016/j.ejmech.2012.07.006 | |||
| CHEMBL2203713 | 83539 | 1 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 326 | 3 | 3 | 4 | 3.3 | N=C(Nc1ccc2c(c1)CCN2C1CCNCC1)c1cccs1 | 10.1016/j.ejmech.2012.07.006 | |||
| 3198 | 205513 | 76 | None | -44 | 34 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | nan | |||
| CHEMBL1201049 | 205513 | 76 | None | -44 | 34 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | nan | |||
| CHEMBL808 | 205513 | 76 | None | -44 | 34 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | nan | |||
| 11744707 | 164909 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 454 | 6 | 0 | 5 | 4.3 | COc1cccc2c1CC1(CCCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1021/jm950861w | |||
| CHEMBL422283 | 164909 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 454 | 6 | 0 | 5 | 4.3 | COc1cccc2c1CC1(CCCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1021/jm950861w | |||
| 10696986 | 52963 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 508 | 7 | 3 | 5 | 4.1 | COc1ccc(NC(=O)NCCN2CCC(c3c[nH]c4cc(F)ccc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
| CHEMBL15965 | 52963 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 508 | 7 | 3 | 5 | 4.1 | COc1ccc(NC(=O)NCCN2CCC(c3c[nH]c4cc(F)ccc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
| 44267181 | 9611 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 277 | 7 | 0 | 3 | 3.4 | CCCN(CCC)CC1COc2cccc(OC)c2C1 | 10.1016/0960-894X(96)00174-6 | |||
| CHEMBL11262 | 9611 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 277 | 7 | 0 | 3 | 3.4 | CCCN(CCC)CC1COc2cccc(OC)c2C1 | 10.1016/0960-894X(96)00174-6 | |||
| 10552023 | 98603 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 462 | 2 | 2 | 3 | 5.1 | CN1CCC2(CC1)COc1ccc(NC(=O)N3CCC(c4c[nH]c5ccc(F)cc45)CC3)cc12 | 10.1021/jm9811054 | |||
| CHEMBL276928 | 98603 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 462 | 2 | 2 | 3 | 5.1 | CN1CCC2(CC1)COc1ccc(NC(=O)N3CCC(c4c[nH]c5ccc(F)cc45)CC3)cc12 | 10.1021/jm9811054 | |||
| 11795333 | 56271 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 401 | 7 | 1 | 6 | 2.9 | c1cc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)ccn1 | 10.1021/jm980569z | |||
| CHEMBL162858 | 56271 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 401 | 7 | 1 | 6 | 2.9 | c1cc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)ccn1 | 10.1021/jm980569z | |||
| 10813272 | 38319 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 446 | 8 | 2 | 5 | 4.6 | CC(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1 | 10.1021/jm9910021 | |||
| CHEMBL146285 | 38319 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 446 | 8 | 2 | 5 | 4.6 | CC(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1 | 10.1021/jm9910021 | |||
| 3191 | 102858 | 97 | None | -17 | 25 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | nan | |||
| CHEMBL305660 | 102858 | 97 | None | -17 | 25 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | nan | |||
| 10378253 | 111397 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 266 | 1 | 0 | 4 | 2.2 | CN1CCN(c2nc3ccccc3n3cccc23)CC1 | 10.1021/jm970376w | |||
| CHEMBL327197 | 111397 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 266 | 1 | 0 | 4 | 2.2 | CN1CCN(c2nc3ccccc3n3cccc23)CC1 | 10.1021/jm970376w | |||
| 10647243 | 98949 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 451 | 4 | 2 | 4 | 4.1 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(F)cc34)C2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
| CHEMBL279646 | 98949 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 451 | 4 | 2 | 4 | 4.1 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(F)cc34)C2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
| 10622257 | 102132 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 424 | 4 | 0 | 5 | 5.5 | c1ccc(CN2CCN(c3nc4scc(-c5ccccc5)c4n4cccc34)CC2)cc1 | 10.1021/jm950543x | |||
| CHEMBL302447 | 102132 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 424 | 4 | 0 | 5 | 5.5 | c1ccc(CN2CCN(c3nc4scc(-c5ccccc5)c4n4cccc34)CC2)cc1 | 10.1021/jm950543x | |||
| 107715 | 200945 | 22 | None | -22 | 19 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 611 | 5 | 3 | 6 | 2.7 | CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O | nan | |||
| CHEMBL1255837 | 200945 | 22 | None | -22 | 19 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 611 | 5 | 3 | 6 | 2.7 | CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O | nan | |||
| CHEMBL601773 | 200945 | 22 | None | -22 | 19 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 611 | 5 | 3 | 6 | 2.7 | CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O | nan | |||
| 10577311 | 39792 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 499 | 10 | 2 | 6 | 4.5 | CC(=O)Nc1ccc(CN(C)CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
| CHEMBL147660 | 39792 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 499 | 10 | 2 | 6 | 4.5 | CC(=O)Nc1ccc(CN(C)CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
| 10835928 | 121071 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 420 | 9 | 1 | 5 | 4.4 | CC(C)=CCCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| CHEMBL357007 | 121071 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 420 | 9 | 1 | 5 | 4.4 | CC(C)=CCCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| 25060119 | 104315 | 0 | None | -32359 | 7 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 493 | 7 | 1 | 5 | 6.1 | COc1ccc(CNC(=O)c2cc(-c3cc(Cl)cc(Cl)c3)cnc2-c2cccnc2)cc1OC | 10.1016/j.bmcl.2013.10.045 | |||
| CHEMBL3099899 | 104315 | 0 | None | -32359 | 7 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 493 | 7 | 1 | 5 | 6.1 | COc1ccc(CNC(=O)c2cc(-c3cc(Cl)cc(Cl)c3)cnc2-c2cccnc2)cc1OC | 10.1016/j.bmcl.2013.10.045 | |||
| 19978038 | 195019 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 267 | 1 | 0 | 5 | 1.6 | CN1CCN(c2nc3cccnc3n3cccc23)CC1 | 10.1021/jm960501o | |||
| CHEMBL54914 | 195019 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 267 | 1 | 0 | 5 | 1.6 | CN1CCN(c2nc3cccnc3n3cccc23)CC1 | 10.1021/jm960501o | |||
| 10623614 | 121050 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 454 | 8 | 2 | 5 | 4.7 | c1ccc2c(c1)CCC2NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| CHEMBL356808 | 121050 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 454 | 8 | 2 | 5 | 4.7 | c1ccc2c(c1)CCC2NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| 10647181 | 100866 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 449 | 8 | 1 | 4 | 5.3 | Fc1ccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm981133m | |||
| CHEMBL293614 | 100866 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 449 | 8 | 1 | 4 | 5.3 | Fc1ccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm981133m | |||
| 135398737 | 958 | 93 | None | -691 | 89 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm970298c | |||
| 38 | 958 | 93 | None | -691 | 89 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm970298c | |||
| 722 | 958 | 93 | None | -691 | 89 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm970298c | |||
| CHEMBL42 | 958 | 93 | None | -691 | 89 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm970298c | |||
| DB00363 | 958 | 93 | None | -691 | 89 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm970298c | |||
| 10838153 | 14101 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 471 | 9 | 2 | 6 | 3.5 | CC(=O)Nc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9704560 | |||
| CHEMBL119785 | 14101 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 471 | 9 | 2 | 6 | 3.5 | CC(=O)Nc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9704560 | |||
| 10832055 | 202734 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 355 | 4 | 2 | 6 | 3.1 | Oc1nc2ccc(CCN3CCN(c4ccccc4O)CC3)cc2s1 | 10.1021/jm970298c | |||
| CHEMBL61869 | 202734 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 355 | 4 | 2 | 6 | 3.1 | Oc1nc2ccc(CCN3CCN(c4ccccc4O)CC3)cc2s1 | 10.1021/jm970298c | |||
| 10838153 | 14101 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 471 | 9 | 2 | 6 | 3.5 | CC(=O)Nc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
| CHEMBL119785 | 14101 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 471 | 9 | 2 | 6 | 3.5 | CC(=O)Nc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
| 11796081 | 54737 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 414 | 9 | 2 | 5 | 3.5 | c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(Cn5cncn5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
| CHEMBL161192 | 54737 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 414 | 9 | 2 | 5 | 3.5 | c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(Cn5cncn5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
| 10691928 | 39924 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 392 | 8 | 1 | 5 | 3.5 | CN(CC1CC1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| CHEMBL147786 | 39924 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 392 | 8 | 1 | 5 | 3.5 | CN(CC1CC1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| 10671996 | 118766 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 468 | 10 | 3 | 4 | 4.0 | CNS(=O)(=O)Cc1ccc2[nH]cc(CCCN3CCC(N[C@H](C)c4ccccc4)CC3)c2c1 | 10.1021/jm9910021 | |||
| CHEMBL341897 | 118766 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 468 | 10 | 3 | 4 | 4.0 | CNS(=O)(=O)Cc1ccc2[nH]cc(CCCN3CCC(N[C@H](C)c4ccccc4)CC3)c2c1 | 10.1021/jm9910021 | |||
| 2477 | 745 | 59 | None | -16 | 29 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00384a001 | |||
| 36 | 745 | 59 | None | -16 | 29 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00384a001 | |||
| 437 | 745 | 59 | None | -16 | 29 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00384a001 | |||
| CHEMBL49 | 745 | 59 | None | -16 | 29 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00384a001 | |||
| DB00490 | 745 | 59 | None | -16 | 29 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00384a001 | |||
| 42 | 2063 | 57 | None | -1778 | 18 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00384a001 | |||
| 56971 | 2063 | 57 | None | -1778 | 18 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00384a001 | |||
| CHEMBL8412 | 2063 | 57 | None | -1778 | 18 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00384a001 | |||
| 10546537 | 120026 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 361 | 6 | 2 | 2 | 3.8 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC(=O)NCc4ccccc4)cc32)C1 | 10.1021/jm000956k | |||
| CHEMBL350277 | 120026 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 361 | 6 | 2 | 2 | 3.8 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC(=O)NCc4ccccc4)cc32)C1 | 10.1021/jm000956k | |||
| 10519608 | 193428 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 318 | 4 | 0 | 4 | 3.2 | c1ccc(CN2CCN(c3ncccc3-n3cccc3)CC2)cc1 | 10.1021/jm960501o | |||
| CHEMBL52612 | 193428 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 318 | 4 | 0 | 4 | 3.2 | c1ccc(CN2CCN(c3ncccc3-n3cccc3)CC2)cc1 | 10.1021/jm960501o | |||
| 2274 | 3173 | 58 | None | -39 | 31 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | |||
| 4917 | 3173 | 58 | None | -39 | 31 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | |||
| 7279 | 3173 | 58 | None | -39 | 31 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | |||
| CHEMBL728 | 3173 | 58 | None | -39 | 31 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | |||
| DB00433 | 3173 | 58 | None | -39 | 31 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | |||
| 10838188 | 167617 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 472 | 4 | 2 | 5 | 4.2 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(C#N)cc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
| CHEMBL430122 | 167617 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 472 | 4 | 2 | 5 | 4.2 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(C#N)cc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
| 10781299 | 11676 | 7 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 194 | 1 | 1 | 2 | 2.1 | Clc1ccc(C2=CCNCC2)cn1 | 10.1016/s0960-894x(99)00575-2 | |||
| CHEMBL1181152 | 11676 | 7 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 194 | 1 | 1 | 2 | 2.1 | Clc1ccc(C2=CCNCC2)cn1 | 10.1016/s0960-894x(99)00575-2 | |||
| CHEMBL157110 | 11676 | 7 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 194 | 1 | 1 | 2 | 2.1 | Clc1ccc(C2=CCNCC2)cn1 | 10.1016/s0960-894x(99)00575-2 | |||
| 19956256 | 115298 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 275 | 4 | 0 | 5 | 2.5 | Cc1csc2c1-n1cccc1/C2=N/OCCN(C)C | 10.1016/s0960-894x(00)00691-0 | |||
| CHEMBL334923 | 115298 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 275 | 4 | 0 | 5 | 2.5 | Cc1csc2c1-n1cccc1/C2=N/OCCN(C)C | 10.1016/s0960-894x(00)00691-0 | |||
| 44341707 | 9464 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 464 | 9 | 2 | 6 | 4.0 | CN(CC1CCCCC1)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
| CHEMBL111899 | 9464 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 464 | 9 | 2 | 6 | 4.0 | CN(CC1CCCCC1)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
| 15516681 | 10202 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 9 | 2 | 6 | 2.9 | CN(CC1CC1)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
| CHEMBL115989 | 10202 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 9 | 2 | 6 | 2.9 | CN(CC1CC1)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
| 2543 | 3707 | 68 | None | -3 | 32 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704560 | |||
| 5358 | 3707 | 68 | None | -3 | 32 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704560 | |||
| 54 | 3707 | 68 | None | -3 | 32 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704560 | |||
| CHEMBL128 | 3707 | 68 | None | -3 | 32 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704560 | |||
| DB00669 | 3707 | 68 | None | -3 | 32 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704560 | |||
| 10596566 | 56569 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 390 | 7 | 1 | 6 | 3.1 | c1cc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)co1 | 10.1021/jm980569z | |||
| CHEMBL164111 | 56569 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 390 | 7 | 1 | 6 | 3.1 | c1cc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)co1 | 10.1021/jm980569z | |||
| 10765655 | 114446 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 442 | 9 | 1 | 5 | 4.5 | CN(Cc1ccccc1)CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| CHEMBL333341 | 114446 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 442 | 9 | 1 | 5 | 4.5 | CN(Cc1ccccc1)CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| 115 | 3791 | 80 | None | 1 | 27 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 10.1021/jm00170a007 | |||
| 4296 | 3791 | 80 | None | 1 | 27 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 10.1021/jm00170a007 | |||
| CHEMBL274866 | 3791 | 80 | None | 1 | 27 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 10.1021/jm00170a007 | |||
| 10526642 | 169273 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 430 | 9 | 3 | 6 | 2.9 | OC[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
| CHEMBL441296 | 169273 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 430 | 9 | 3 | 6 | 2.9 | OC[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
| 10838030 | 23507 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 468 | 8 | 0 | 5 | 4.7 | CCCN1CCCC12COc1cccc(OCCCCN3C(=O)CC4(CCCC4)CC3=O)c1C2 | 10.1021/jm950861w | |||
| CHEMBL133375 | 23507 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 468 | 8 | 0 | 5 | 4.7 | CCCN1CCCC12COc1cccc(OCCCCN3C(=O)CC4(CCCC4)CC3=O)c1C2 | 10.1021/jm950861w | |||
| 2812 | 4779 | 101 | None | -51 | 34 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | |||
| CHEMBL104 | 4779 | 101 | None | -51 | 34 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | |||
| 10596387 | 168459 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 387 | 7 | 1 | 5 | 3.6 | c1ccc(CO[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
| CHEMBL435060 | 168459 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 387 | 7 | 1 | 5 | 3.6 | c1ccc(CO[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
| 10805740 | 89274 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 321 | 5 | 2 | 3 | 2.0 | CNS(=O)(=O)Cc1ccc2[nH]cc([C@H]3C[C@H](N(C)C)C3)c2c1 | 10.1021/jm000956k | |||
| CHEMBL2368259 | 89274 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 321 | 5 | 2 | 3 | 2.0 | CNS(=O)(=O)Cc1ccc2[nH]cc([C@H]3C[C@H](N(C)C)C3)c2c1 | 10.1021/jm000956k | |||
| 277 | 1301 | 62 | None | -501 | 50 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | |||
| 2913 | 1301 | 62 | None | -501 | 50 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | |||
| 765 | 1301 | 62 | None | -501 | 50 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | |||
| CHEMBL516 | 1301 | 62 | None | -501 | 50 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | |||
| DB00434 | 1301 | 62 | None | -501 | 50 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | |||
| 10765655 | 114446 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 442 | 9 | 1 | 5 | 4.5 | CN(Cc1ccccc1)CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9704558 | |||
| CHEMBL333341 | 114446 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 442 | 9 | 1 | 5 | 4.5 | CN(Cc1ccccc1)CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9704558 | |||
| 10468938 | 10244 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 281 | 4 | 1 | 4 | 2.4 | c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1 | 10.1021/jm980569z | |||
| CHEMBL116092 | 10244 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 281 | 4 | 1 | 4 | 2.4 | c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1 | 10.1021/jm980569z | |||
| 10468938 | 10244 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 281 | 4 | 1 | 4 | 2.4 | c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1 | 10.1021/jm9805687 | |||
| CHEMBL116092 | 10244 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 281 | 4 | 1 | 4 | 2.4 | c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1 | 10.1021/jm9805687 | |||
| 10468938 | 10244 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 281 | 4 | 1 | 4 | 2.4 | c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1 | 10.1021/jm9910021 | |||
| CHEMBL116092 | 10244 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 281 | 4 | 1 | 4 | 2.4 | c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1 | 10.1021/jm9910021 | |||
| 10812465 | 35531 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 428 | 9 | 2 | 5 | 4.2 | c1ccc(CNCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
| CHEMBL143893 | 35531 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 428 | 9 | 2 | 5 | 4.2 | c1ccc(CNCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
| 10551328 | 203721 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 445 | 8 | 1 | 4 | 5.7 | CC(CC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm981133m | |||
| CHEMBL67684 | 203721 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 445 | 8 | 1 | 4 | 5.7 | CC(CC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm981133m | |||
| 10718277 | 203262 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 447 | 6 | 0 | 4 | 4.2 | CN1C(=O)COc2cc(CCCCN3CCN(c4cccc(C(F)(F)F)c4)CC3)ccc21 | 10.1021/jm970298c | |||
| CHEMBL64610 | 203262 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 447 | 6 | 0 | 4 | 4.2 | CN1C(=O)COc2cc(CCCCN3CCN(c4cccc(C(F)(F)F)c4)CC3)ccc21 | 10.1021/jm970298c | |||
| 9930155 | 164032 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 387 | 7 | 1 | 5 | 3.6 | c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9704558 | |||
| CHEMBL420874 | 164032 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 387 | 7 | 1 | 5 | 3.6 | c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9704558 | |||
| 10836850 | 40277 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 440 | 7 | 2 | 5 | 4.4 | c1ccc2c(c1)CCC2NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| CHEMBL148095 | 40277 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 440 | 7 | 2 | 5 | 4.4 | c1ccc2c(c1)CCC2NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| 10766570 | 203380 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 464 | 8 | 1 | 5 | 4.2 | CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1cccc(F)c1 | 10.1021/jm981133m | |||
| CHEMBL65321 | 203380 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 464 | 8 | 1 | 5 | 4.2 | CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1cccc(F)c1 | 10.1021/jm981133m | |||
| 9866484 | 56278 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 414 | 7 | 1 | 5 | 3.0 | O=C1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CCN1Cc1ccccc1 | 10.1021/jm980569z | |||
| CHEMBL162899 | 56278 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 414 | 7 | 1 | 5 | 3.0 | O=C1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CCN1Cc1ccccc1 | 10.1021/jm980569z | |||
| 11798502 | 56493 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 468 | 7 | 1 | 5 | 4.5 | FC(F)(F)c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
| CHEMBL163376 | 56493 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 468 | 7 | 1 | 5 | 4.5 | FC(F)(F)c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
| 73351903 | 89695 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 360 | 3 | 2 | 4 | 3.1 | Cc1[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
| CHEMBL2376484 | 89695 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 360 | 3 | 2 | 4 | 3.1 | Cc1[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
| 5 | 139 | 72 | None | -11 | 54 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm8007618 | |||
| 5202 | 139 | 72 | None | -11 | 54 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm8007618 | |||
| CHEMBL39 | 139 | 72 | None | -11 | 54 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm8007618 | |||
| DB08839 | 139 | 72 | None | -11 | 54 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm8007618 | |||
| 15951337 | 125387 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 338 | 4 | 2 | 3 | 3.9 | CN1CCC[C@H]1Cc1c[nH]c2ccc(/N=C(\N)c3cccs3)cc12 | nan | |||
| CHEMBL3645476 | 125387 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 338 | 4 | 2 | 3 | 3.9 | CN1CCC[C@H]1Cc1c[nH]c2ccc(/N=C(\N)c3cccs3)cc12 | nan | |||
| CHEMBL1200558 | 208599 | 21 | None | - | 1 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](N)C1=N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H]2CCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H](CCCN)NC2=O)[C@@H](C)CC)CS1 | nan | |||||
| 10550857 | 203446 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 435 | 7 | 1 | 4 | 4.9 | Fc1ccccc1CC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
| CHEMBL65824 | 203446 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 435 | 7 | 1 | 4 | 4.9 | Fc1ccccc1CC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
| 2763724 | 98477 | 64 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 276 | 1 | 2 | 1 | 3.3 | Brc1ccc2[nH]cc(C3=CCNCC3)c2c1 | 10.1021/jm00170a007 | |||
| CHEMBL27592 | 98477 | 64 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 276 | 1 | 2 | 1 | 3.3 | Brc1ccc2[nH]cc(C3=CCNCC3)c2c1 | 10.1021/jm00170a007 | |||
| 10573904 | 121308 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 415 | 8 | 2 | 6 | 3.9 | c1ccc(NCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1 | 10.1021/jm9910021 | |||
| CHEMBL358072 | 121308 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 415 | 8 | 2 | 6 | 3.9 | c1ccc(NCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1 | 10.1021/jm9910021 | |||
| 3050532 | 99447 | 7 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 232 | 1 | 2 | 1 | 3.2 | Clc1ccc2[nH]cc(C3=CCNCC3)c2c1 | 10.1021/jm00170a007 | |||
| CHEMBL282994 | 99447 | 7 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 232 | 1 | 2 | 1 | 3.2 | Clc1ccc2[nH]cc(C3=CCNCC3)c2c1 | 10.1021/jm00170a007 | |||
| 53263 | 99495 | 17 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 243 | 2 | 2 | 3 | 2.5 | O=[N+]([O-])c1ccc2[nH]cc(C3=CCNCC3)c2c1 | 10.1021/jm00170a007 | |||
| CHEMBL283257 | 99495 | 17 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 243 | 2 | 2 | 3 | 2.5 | O=[N+]([O-])c1ccc2[nH]cc(C3=CCNCC3)c2c1 | 10.1021/jm00170a007 | |||
| 2761023 | 98766 | 71 | None | - | 3 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 198 | 1 | 2 | 1 | 2.5 | C1=C(c2c[nH]c3ccccc23)CCNC1 | 10.1021/jm00170a007 | |||
| CHEMBL2011570 | 98766 | 71 | None | - | 3 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 198 | 1 | 2 | 1 | 2.5 | C1=C(c2c[nH]c3ccccc23)CCNC1 | 10.1021/jm00170a007 | |||
| CHEMBL27811 | 98766 | 71 | None | - | 3 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 198 | 1 | 2 | 1 | 2.5 | C1=C(c2c[nH]c3ccccc23)CCNC1 | 10.1021/jm00170a007 | |||
| 44341625 | 111317 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 501 | 10 | 4 | 7 | 3.3 | CC(=O)Nc1ccc(CNCC2(O)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1016/s0960-894x(99)00614-9 | |||
| CHEMBL326723 | 111317 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 501 | 10 | 4 | 7 | 3.3 | CC(=O)Nc1ccc(CNCC2(O)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1016/s0960-894x(99)00614-9 | |||
| 10477461 | 113393 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 424 | 9 | 2 | 6 | 3.1 | CC(C)CN(C)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
| CHEMBL331819 | 113393 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 424 | 9 | 2 | 6 | 3.1 | CC(C)CN(C)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
| 73453 | 29616 | 24 | None | -26 | 17 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 561 | 4 | 3 | 6 | 2.0 | CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 | nan | |||
| CHEMBL1385840 | 29616 | 24 | None | -26 | 17 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 561 | 4 | 3 | 6 | 2.0 | CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 | nan | |||
| 10468938 | 10244 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 281 | 4 | 1 | 4 | 2.4 | c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1 | 10.1021/jm9704558 | |||
| CHEMBL116092 | 10244 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 281 | 4 | 1 | 4 | 2.4 | c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1 | 10.1021/jm9704558 | |||
| 10468938 | 10244 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 281 | 4 | 1 | 4 | 2.4 | c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1 | 10.1021/jm9704560 | |||
| CHEMBL116092 | 10244 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 281 | 4 | 1 | 4 | 2.4 | c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1 | 10.1021/jm9704560 | |||
| 9821397 | 100921 | 21 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 383 | 5 | 0 | 6 | 3.0 | COc1ccccc1N1CCN(CCc2ccc3c(c2)sc(=O)n3C)CC1 | 10.1021/jm970298c | |||
| CHEMBL293923 | 100921 | 21 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 383 | 5 | 0 | 6 | 3.0 | COc1ccccc1N1CCN(CCc2ccc3c(c2)sc(=O)n3C)CC1 | 10.1021/jm970298c | |||
| 10759541 | 200154 | 1 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 339 | 4 | 1 | 5 | 3.4 | Oc1nc2ccc(CCN3CCN(c4ccccc4)CC3)cc2s1 | 10.1021/jm970298c | |||
| CHEMBL59637 | 200154 | 1 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 339 | 4 | 1 | 5 | 3.4 | Oc1nc2ccc(CCN3CCN(c4ccccc4)CC3)cc2s1 | 10.1021/jm970298c | |||
| 10501785 | 202728 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 411 | 7 | 0 | 6 | 3.8 | COc1ccccc1N1CCN(CCCCc2ccc3c(c2)sc(=O)n3C)CC1 | 10.1021/jm970298c | |||
| CHEMBL61819 | 202728 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 411 | 7 | 0 | 6 | 3.8 | COc1ccccc1N1CCN(CCCCc2ccc3c(c2)sc(=O)n3C)CC1 | 10.1021/jm970298c | |||
| 10625376 | 52451 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 505 | 5 | 3 | 4 | 4.7 | CN1CCC2(CC1)COc1ccc(NC(=O)NCCN3CCC(c4c[nH]c5cc(F)ccc45)CC3)cc12 | 10.1021/jm9811054 | |||
| CHEMBL15909 | 52451 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 505 | 5 | 3 | 4 | 4.7 | CN1CCC2(CC1)COc1ccc(NC(=O)NCCN3CCC(c4c[nH]c5cc(F)ccc45)CC3)cc12 | 10.1021/jm9811054 | |||
| 44364110 | 35535 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 456 | 7 | 3 | 6 | 3.4 | O[C@H]1Cc2ccccc2C1NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| CHEMBL143894 | 35535 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 456 | 7 | 3 | 6 | 3.4 | O[C@H]1Cc2ccccc2C1NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| 71461714 | 79648 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 500 | 8 | 2 | 5 | 4.9 | F[C@@H]1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC[C@@H]1NCc1ccccc1C(F)(F)F | 10.1021/jm981133m | |||
| CHEMBL2115111 | 79648 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 500 | 8 | 2 | 5 | 4.9 | F[C@@H]1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC[C@@H]1NCc1ccccc1C(F)(F)F | 10.1021/jm981133m | |||
| 10809238 | 201141 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 371 | 4 | 0 | 5 | 3.1 | Cn1c(=O)sc2cc(CCN3CCN(c4ccc(F)cc4)CC3)ccc21 | 10.1021/jm970298c | |||
| CHEMBL60318 | 201141 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 371 | 4 | 0 | 5 | 3.1 | Cn1c(=O)sc2cc(CCN3CCN(c4ccc(F)cc4)CC3)ccc21 | 10.1021/jm970298c | |||
| 10319624 | 98987 | 0 | None | - | 1 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 414 | 10 | 1 | 4 | 4.1 | CCCN(CCCCNC(=O)c1ccc(F)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL27991 | 98987 | 0 | None | - | 1 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 414 | 10 | 1 | 4 | 4.1 | CCCN(CCCCNC(=O)c1ccc(F)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL298534 | 98987 | 0 | None | - | 1 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 414 | 10 | 1 | 4 | 4.1 | CCCN(CCCCNC(=O)c1ccc(F)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| 10070029 | 165417 | 0 | None | - | 1 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 408 | 8 | 0 | 5 | 3.4 | CCCN(CCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL423841 | 165417 | 0 | None | - | 1 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 408 | 8 | 0 | 5 | 3.4 | CCCN(CCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL54089 | 165417 | 0 | None | - | 1 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 408 | 8 | 0 | 5 | 3.4 | CCCN(CCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| 10812693 | 102753 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 433 | 8 | 1 | 5 | 4.3 | FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(OCc2ccccc2)CC1 | 10.1021/jm981133m | |||
| CHEMBL305062 | 102753 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 433 | 8 | 1 | 5 | 4.3 | FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(OCc2ccccc2)CC1 | 10.1021/jm981133m | |||
| 10251234 | 11245 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 414 | 9 | 0 | 5 | 3.3 | CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL1178932 | 11245 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 414 | 9 | 0 | 5 | 3.3 | CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL50530 | 11245 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 414 | 9 | 0 | 5 | 3.3 | CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| 10092409 | 12046 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 400 | 9 | 0 | 4 | 3.7 | CCCN(CCCCN1CC2CCCC2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL1183479 | 12046 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 400 | 9 | 0 | 4 | 3.7 | CCCN(CCCCN1CC2CCCC2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL299561 | 12046 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 400 | 9 | 0 | 4 | 3.7 | CCCN(CCCCN1CC2CCCC2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| 10047322 | 97140 | 0 | None | - | 1 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 412 | 8 | 0 | 4 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2ccccc2C1 | 10.1021/jm00038a007 | |||
| CHEMBL26783 | 97140 | 0 | None | - | 1 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 412 | 8 | 0 | 4 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2ccccc2C1 | 10.1021/jm00038a007 | |||
| CHEMBL50993 | 97140 | 0 | None | - | 1 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 412 | 8 | 0 | 4 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2ccccc2C1 | 10.1021/jm00038a007 | |||
| 11743327 | 98702 | 0 | None | - | 1 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 428 | 8 | 1 | 5 | 3.9 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(O)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL27763 | 98702 | 0 | None | - | 1 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 428 | 8 | 1 | 5 | 3.9 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(O)c2C1 | 10.1021/jm00038a007 | |||
| 10265863 | 193324 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 283 | 5 | 0 | 2 | 4.3 | CCCN(CCC)C1COc2ccc3ccccc3c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL52438 | 193324 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 283 | 5 | 0 | 2 | 4.3 | CCCN(CCC)C1COc2ccc3ccccc3c2C1 | 10.1021/jm00038a007 | |||
| 6761 | 67799 | 19 | None | -43 | 18 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 401 | 5 | 1 | 4 | 4.5 | NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 | nan | |||
| CHEMBL1909072 | 67799 | 19 | None | -43 | 18 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 401 | 5 | 1 | 4 | 4.5 | NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 | nan | |||
| 10409556 | 162372 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 414 | 8 | 1 | 5 | 3.3 | COc1cccc2c1CC(CNCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1016/0960-894X(96)00174-6 | |||
| CHEMBL416523 | 162372 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 414 | 8 | 1 | 5 | 3.3 | COc1cccc2c1CC(CNCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1016/0960-894X(96)00174-6 | |||
| 10614906 | 110505 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 310 | 4 | 1 | 5 | 1.5 | CN1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
| CHEMBL324931 | 110505 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 310 | 4 | 1 | 5 | 1.5 | CN1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
| 11796807 | 165543 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 428 | 9 | 2 | 5 | 4.0 | C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
| CHEMBL424154 | 165543 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 428 | 9 | 2 | 5 | 4.0 | C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
| 9949172 | 10873 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 324 | 5 | 1 | 5 | 1.9 | CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
| CHEMBL117249 | 10873 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 324 | 5 | 1 | 5 | 1.9 | CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
| 11794853 | 203075 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 392 | 3 | 0 | 7 | 3.6 | c1cc2c(N3CCN(Cc4ccc5c(c4)OCO5)CC3)nc3ccsc3n2c1 | 10.1021/jm950543x | |||
| CHEMBL63790 | 203075 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 392 | 3 | 0 | 7 | 3.6 | c1cc2c(N3CCN(Cc4ccc5c(c4)OCO5)CC3)nc3ccsc3n2c1 | 10.1021/jm950543x | |||
| 10499348 | 201364 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 369 | 4 | 1 | 6 | 2.7 | Cn1c(=O)sc2cc(CCN3CCN(c4ccccc4O)CC3)ccc21 | 10.1021/jm970298c | |||
| CHEMBL60447 | 201364 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 369 | 4 | 1 | 6 | 2.7 | Cn1c(=O)sc2cc(CCN3CCN(c4ccccc4O)CC3)ccc21 | 10.1021/jm970298c | |||
| 15951272 | 125386 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 338 | 4 | 2 | 3 | 3.9 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(/N=C(\N)c3cccs3)cc12 | nan | |||
| CHEMBL3645475 | 125386 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 338 | 4 | 2 | 3 | 3.9 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(/N=C(\N)c3cccs3)cc12 | nan | |||
| 10614906 | 110505 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 310 | 4 | 1 | 5 | 1.5 | CN1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9704560 | |||
| CHEMBL324931 | 110505 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 310 | 4 | 1 | 5 | 1.5 | CN1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9704560 | |||
| 10600213 | 203109 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 464 | 8 | 1 | 5 | 4.2 | CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1 | 10.1021/jm981133m | |||
| CHEMBL64004 | 203109 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 464 | 8 | 1 | 5 | 4.2 | CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1 | 10.1021/jm981133m | |||
| 3066250 | 70286 | 2 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 242 | 2 | 2 | 2 | 2.9 | COc1ccc2[nH]c(C)c(C3=CCNCC3)c2c1 | 10.1016/j.bmcl.2005.06.067 | |||
| CHEMBL194305 | 70286 | 2 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 242 | 2 | 2 | 2 | 2.9 | COc1ccc2[nH]c(C)c(C3=CCNCC3)c2c1 | 10.1016/j.bmcl.2005.06.067 | |||
| 9911120 | 9623 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 440 | 6 | 0 | 5 | 4.0 | COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1021/jm950861w | |||
| CHEMBL11265 | 9623 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 440 | 6 | 0 | 5 | 4.0 | COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1021/jm950861w | |||
| 10617665 | 52762 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 347 | 5 | 2 | 2 | 3.9 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(C(=O)NCc4ccccc4)cc32)C1 | 10.1021/jm000956k | |||
| CHEMBL159470 | 52762 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 347 | 5 | 2 | 2 | 3.9 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(C(=O)NCc4ccccc4)cc32)C1 | 10.1021/jm000956k | |||
| 44267852 | 11195 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 436 | 7 | 1 | 5 | 4.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COc2c(ccc3ccccc23)O1 | 10.1021/jm00401a007 | |||
| CHEMBL11787 | 11195 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 436 | 7 | 1 | 5 | 4.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COc2c(ccc3ccccc23)O1 | 10.1021/jm00401a007 | |||
| 10714457 | 101716 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 374 | 4 | 0 | 4 | 3.9 | Fc1ccc(CN2CCN(Cc3nc4ccccc4n4cccc34)CC2)cc1 | 10.1021/jm960501o | |||
| CHEMBL299524 | 101716 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 374 | 4 | 0 | 4 | 3.9 | Fc1ccc(CN2CCN(Cc3nc4ccccc4n4cccc34)CC2)cc1 | 10.1021/jm960501o | |||
| 1971 | 2866 | 38 | None | -18 | 30 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | nan | |||
| 2404 | 2866 | 38 | None | -18 | 30 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | nan | |||
| 4543 | 2866 | 38 | None | -18 | 30 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | nan | |||
| CHEMBL445 | 2866 | 38 | None | -18 | 30 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | nan | |||
| DB00540 | 2866 | 38 | None | -18 | 30 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | nan | |||
| 11668825 | 9591 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 415 | 7 | 2 | 5 | 3.8 | OC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
| CHEMBL112507 | 9591 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 415 | 7 | 2 | 5 | 3.8 | OC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
| 10501944 | 11037 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 414 | 8 | 1 | 5 | 3.7 | CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9805687 | |||
| CHEMBL117579 | 11037 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 414 | 8 | 1 | 5 | 3.7 | CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9805687 | |||
| 18691566 | 89271 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 299 | 4 | 3 | 3 | 2.3 | CN[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1 | 10.1021/jm000956k | |||
| CHEMBL2368256 | 89271 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 299 | 4 | 3 | 3 | 2.3 | CN[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1 | 10.1021/jm000956k | |||
| 10571716 | 40494 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 378 | 8 | 1 | 5 | 3.3 | C=CCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| CHEMBL148286 | 40494 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 378 | 8 | 1 | 5 | 3.3 | C=CCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| 969502 | 98111 | 4 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)[C@H](N1CCN(C)CC1)Cc1ccccc1S2 | 10.1021/jm00401a007 | |||
| CHEMBL1314789 | 98111 | 4 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)[C@H](N1CCN(C)CC1)Cc1ccccc1S2 | 10.1021/jm00401a007 | |||
| CHEMBL273490 | 98111 | 4 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)[C@H](N1CCN(C)CC1)Cc1ccccc1S2 | 10.1021/jm00401a007 | |||
| 10689227 | 55817 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 350 | 8 | 2 | 5 | 2.4 | C=CCNC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9805687 | |||
| CHEMBL162296 | 55817 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 350 | 8 | 2 | 5 | 2.4 | C=CCNC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9805687 | |||
| 10501944 | 11037 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 414 | 8 | 1 | 5 | 3.7 | CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9704558 | |||
| CHEMBL117579 | 11037 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 414 | 8 | 1 | 5 | 3.7 | CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9704558 | |||
| 10693206 | 55162 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 415 | 9 | 1 | 5 | 4.2 | c1ccc(COC[C@@H]2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
| CHEMBL161735 | 55162 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 415 | 9 | 1 | 5 | 4.2 | c1ccc(COC[C@@H]2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
| 109 | 902 | 31 | None | - | 7 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 334 | 1 | 0 | 4 | 3.3 | CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F | 10.1021/jm950543x | |||
| 2689 | 902 | 31 | None | - | 7 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 334 | 1 | 0 | 4 | 3.3 | CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F | 10.1021/jm950543x | |||
| CHEMBL27403 | 902 | 31 | None | - | 7 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 334 | 1 | 0 | 4 | 3.3 | CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F | 10.1021/jm950543x | |||
| 109 | 902 | 31 | None | - | 7 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 334 | 1 | 0 | 4 | 3.3 | CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F | 10.1021/jm960501o | |||
| 2689 | 902 | 31 | None | - | 7 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 334 | 1 | 0 | 4 | 3.3 | CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F | 10.1021/jm960501o | |||
| CHEMBL27403 | 902 | 31 | None | - | 7 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 334 | 1 | 0 | 4 | 3.3 | CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F | 10.1021/jm960501o | |||
| 11796209 | 203388 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 416 | 3 | 0 | 5 | 5.2 | Clc1ccc(CN2CCN(c3nc4sccc4n4cccc34)CC2)cc1Cl | 10.1021/jm950543x | |||
| CHEMBL65413 | 203388 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 416 | 3 | 0 | 5 | 5.2 | Clc1ccc(CN2CCN(c3nc4sccc4n4cccc34)CC2)cc1Cl | 10.1021/jm950543x | |||
| 10766320 | 38293 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 458 | 10 | 3 | 6 | 3.7 | OC[C@@H](NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL146265 | 38293 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 458 | 10 | 3 | 6 | 3.7 | OC[C@@H](NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| 44341783 | 10099 | 1 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 454 | 7 | 3 | 7 | 3.0 | CC(C)(C)OC(=O)NCC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
| CHEMBL115496 | 10099 | 1 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 454 | 7 | 3 | 7 | 3.0 | CC(C)(C)OC(=O)NCC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
| 49836386 | 18550 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 253 | 2 | 1 | 2 | 3.2 | CN(C)[C@@H]1CC[C@H](c2c[nH]c3ccc(C#N)cc23)C1 | 10.1021/jm100515z | |||
| CHEMBL1275709 | 18550 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 253 | 2 | 1 | 2 | 3.2 | CN(C)[C@@H]1CC[C@H](c2c[nH]c3ccc(C#N)cc23)C1 | 10.1021/jm100515z | |||
| 31703 | 194717 | 63 | None | -1 | 2 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | nan | |||
| CHEMBL359744 | 194717 | 63 | None | -1 | 2 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | nan | |||
| CHEMBL53463 | 194717 | 63 | None | -1 | 2 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | nan | |||
| 10764998 | 113489 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 428 | 8 | 2 | 5 | 4.5 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9704558 | |||
| CHEMBL331970 | 113489 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 428 | 8 | 2 | 5 | 4.5 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9704558 | |||
| 10502988 | 38012 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 434 | 8 | 1 | 6 | 4.3 | CN(Cc1ccsc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| CHEMBL146024 | 38012 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 434 | 8 | 1 | 6 | 4.3 | CN(Cc1ccsc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| 10764998 | 113489 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 428 | 8 | 2 | 5 | 4.5 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL331970 | 113489 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 428 | 8 | 2 | 5 | 4.5 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| 10838622 | 38164 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 485 | 9 | 3 | 6 | 4.5 | CC(=O)Nc1ccc([C@@H](C)NC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
| CHEMBL146150 | 38164 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 485 | 9 | 3 | 6 | 4.5 | CC(=O)Nc1ccc([C@@H](C)NC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
| 44296810 | 161994 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 404 | 7 | 0 | 7 | 3.3 | COc1ccc2c(c1)nc(N1CCN(CCCCn3cccn3)CC1)c1cccn12 | 10.1021/jm960501o | |||
| CHEMBL415933 | 161994 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 404 | 7 | 0 | 7 | 3.3 | COc1ccc2c(c1)nc(N1CCN(CCCCn3cccn3)CC1)c1cccn12 | 10.1021/jm960501o | |||
| 44267205 | 98409 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 366 | 5 | 0 | 4 | 3.6 | CCCN1CCN(Cc2ccccc2)CC12COc1cccc(OC)c1C2 | 10.1016/0960-894X(96)00174-6 | |||
| CHEMBL275481 | 98409 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 366 | 5 | 0 | 4 | 3.6 | CCCN1CCN(Cc2ccccc2)CC12COc1cccc(OC)c1C2 | 10.1016/0960-894X(96)00174-6 | |||
| 11005810 | 10466 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 517 | 10 | 1 | 4 | 6.2 | N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm010878g | |||
| CHEMBL116463 | 10466 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 517 | 10 | 1 | 4 | 6.2 | N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm010878g | |||
| 26987 | 949 | 33 | None | -138 | 21 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | nan | |||
| 6063 | 949 | 33 | None | -138 | 21 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | nan | |||
| 671 | 949 | 33 | None | -138 | 21 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | nan | |||
| CHEMBL1626 | 949 | 33 | None | -138 | 21 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | nan | |||
| DB00283 | 949 | 33 | None | -138 | 21 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | nan | |||
| 10548444 | 56913 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 390 | 7 | 2 | 6 | 2.2 | c1c[nH]c(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)n1 | 10.1021/jm980569z | |||
| CHEMBL164413 | 56913 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 390 | 7 | 2 | 6 | 2.2 | c1c[nH]c(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)n1 | 10.1021/jm980569z | |||
| 10644514 | 101057 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 397 | 6 | 0 | 6 | 3.4 | COc1ccccc1N1CCN(CCCc2ccc3c(c2)sc(=O)n3C)CC1 | 10.1021/jm970298c | |||
| CHEMBL294730 | 101057 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 397 | 6 | 0 | 6 | 3.4 | COc1ccccc1N1CCN(CCCc2ccc3c(c2)sc(=O)n3C)CC1 | 10.1021/jm970298c | |||
| 18975338 | 102617 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 416 | 7 | 2 | 6 | 2.5 | OC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCN(Cc2ccccc2)CC1 | 10.1021/jm981133m | |||
| CHEMBL304197 | 102617 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 416 | 7 | 2 | 6 | 2.5 | OC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCN(Cc2ccccc2)CC1 | 10.1021/jm981133m | |||
| 10386282 | 164100 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 400 | 8 | 2 | 5 | 3.4 | c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm980569z | |||
| CHEMBL420965 | 164100 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 400 | 8 | 2 | 5 | 3.4 | c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm980569z | |||
| 376254 | 118504 | 2 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 284 | 1 | 0 | 4 | 2.4 | CN1CCN(c2nc3cc(F)ccc3n3cccc23)CC1 | 10.1021/jm970376w | |||
| CHEMBL341474 | 118504 | 2 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 284 | 1 | 0 | 4 | 2.4 | CN1CCN(c2nc3cc(F)ccc3n3cccc23)CC1 | 10.1021/jm970376w | |||
| 180 | 401 | 56 | None | -389 | 40 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | |||
| 200 | 401 | 56 | None | -389 | 40 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | |||
| 2160 | 401 | 56 | None | -389 | 40 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | |||
| CHEMBL629 | 401 | 56 | None | -389 | 40 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | |||
| DB00321 | 401 | 56 | None | -389 | 40 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | |||
| 10600212 | 102713 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 464 | 8 | 1 | 5 | 4.2 | CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1F | 10.1021/jm981133m | |||
| CHEMBL304833 | 102713 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 464 | 8 | 1 | 5 | 4.2 | CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1F | 10.1021/jm981133m | |||
| 173 | 3262 | 95 | None | -2 | 23 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm970376w | |||
| 5011 | 3262 | 95 | None | -2 | 23 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm970376w | |||
| CHEMBL18772 | 3262 | 95 | None | -2 | 23 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm970376w | |||
| 9911120 | 9623 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 440 | 6 | 0 | 5 | 4.0 | COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1021/jm950861w | |||
| CHEMBL11265 | 9623 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 440 | 6 | 0 | 5 | 4.0 | COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1021/jm950861w | |||
| 10835403 | 26416 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 410 | 5 | 0 | 4 | 3.9 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCCC12COc1ccccc1C2 | 10.1021/jm950861w | |||
| CHEMBL135952 | 26416 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 410 | 5 | 0 | 4 | 3.9 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCCC12COc1ccccc1C2 | 10.1021/jm950861w | |||
| 1220 | 187 | 55 | None | -7413 | 44 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1021/jm00401a007 | |||
| 31 | 187 | 55 | None | -7413 | 44 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1021/jm00401a007 | |||
| 7 | 187 | 55 | None | -7413 | 44 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1021/jm00401a007 | |||
| CHEMBL56 | 187 | 55 | None | -7413 | 44 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1021/jm00401a007 | |||
| 10665840 | 89275 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 354 | 4 | 2 | 3 | 2.8 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CN4C(=O)NC(C)(C)C4=O)cc32)C1 | 10.1021/jm000956k | |||
| CHEMBL2368260 | 89275 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 354 | 4 | 2 | 3 | 2.8 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CN4C(=O)NC(C)(C)C4=O)cc32)C1 | 10.1021/jm000956k | |||
| 9911120 | 9623 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 440 | 6 | 0 | 5 | 4.0 | COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1016/0960-894X(96)00174-6 | |||
| CHEMBL11265 | 9623 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 440 | 6 | 0 | 5 | 4.0 | COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1016/0960-894X(96)00174-6 | |||
| 10546440 | 194915 | 0 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 360 | 3 | 0 | 4 | 3.9 | Fc1ccc(CN2CCN(c3nc4ccccc4n4cccc34)CC2)cc1 | 10.1021/jm960501o | |||
| CHEMBL54125 | 194915 | 0 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 360 | 3 | 0 | 4 | 3.9 | Fc1ccc(CN2CCN(c3nc4ccccc4n4cccc34)CC2)cc1 | 10.1021/jm960501o | |||
| 10852406 | 52840 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 309 | 4 | 2 | 3 | 3.0 | Cc1nc(Cc2ccc3[nH]cc([C@H]4C[C@H](N(C)C)C4)c3c2)n[nH]1 | 10.1021/jm000956k | |||
| CHEMBL159536 | 52840 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 309 | 4 | 2 | 3 | 3.0 | Cc1nc(Cc2ccc3[nH]cc([C@H]4C[C@H](N(C)C)C4)c3c2)n[nH]1 | 10.1021/jm000956k | |||
| 10502669 | 56561 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 428 | 8 | 2 | 5 | 4.1 | CC(C)(NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
| CHEMBL164046 | 56561 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 428 | 8 | 2 | 5 | 4.1 | CC(C)(NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
| 10764284 | 55434 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 414 | 7 | 1 | 5 | 3.0 | O=C1CN(Cc2ccccc2)CCN1CCCc1c[nH]c2ccc(-n3cnnc3)cc12 | 10.1021/jm980569z | |||
| CHEMBL161969 | 55434 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 414 | 7 | 1 | 5 | 3.0 | O=C1CN(Cc2ccccc2)CCN1CCCc1c[nH]c2ccc(-n3cnnc3)cc12 | 10.1021/jm980569z | |||
| 13673326 | 16414 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 436 | 7 | 1 | 5 | 4.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COc2ccc3ccccc3c2O1 | 10.1021/jm00401a007 | |||
| CHEMBL12311 | 16414 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 436 | 7 | 1 | 5 | 4.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COc2ccc3ccccc3c2O1 | 10.1021/jm00401a007 | |||
| 23374587 | 54572 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 267 | 4 | 1 | 4 | 2.0 | c1cc2[nH]cc(CCN3CCC3)c2cc1-n1cnnc1 | 10.1021/jm9805687 | |||
| CHEMBL161045 | 54572 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 267 | 4 | 1 | 4 | 2.0 | c1cc2[nH]cc(CCN3CCC3)c2cc1-n1cnnc1 | 10.1021/jm9805687 | |||
| 5 | 139 | 72 | None | -13 | 54 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm970376w | |||
| 5202 | 139 | 72 | None | -13 | 54 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm970376w | |||
| CHEMBL39 | 139 | 72 | None | -13 | 54 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm970376w | |||
| DB08839 | 139 | 72 | None | -13 | 54 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm970376w | |||
| 5 | 139 | 72 | None | -13 | 54 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2016.03.006 | |||
| 5202 | 139 | 72 | None | -13 | 54 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2016.03.006 | |||
| CHEMBL39 | 139 | 72 | None | -13 | 54 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2016.03.006 | |||
| DB08839 | 139 | 72 | None | -13 | 54 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2016.03.006 | |||
| 5 | 139 | 72 | None | -13 | 54 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2016.11.014 | |||
| 5202 | 139 | 72 | None | -13 | 54 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2016.11.014 | |||
| CHEMBL39 | 139 | 72 | None | -13 | 54 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2016.11.014 | |||
| DB08839 | 139 | 72 | None | -13 | 54 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2016.11.014 | |||
| 10768115 | 119725 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 513 | 9 | 2 | 6 | 4.1 | CC(=O)Nc1ccc(C(=O)N(C)CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
| CHEMBL347570 | 119725 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 513 | 9 | 2 | 6 | 4.1 | CC(=O)Nc1ccc(C(=O)N(C)CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
| 10789000 | 203318 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 435 | 6 | 1 | 5 | 5.2 | Oc1nc2ccc(CCCCN3CCN(c4cccc(C(F)(F)F)c4)CC3)cc2s1 | 10.1021/jm970298c | |||
| CHEMBL64845 | 203318 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 435 | 6 | 1 | 5 | 5.2 | Oc1nc2ccc(CCCCN3CCN(c4cccc(C(F)(F)F)c4)CC3)cc2s1 | 10.1021/jm970298c | |||
| 10251673 | 99490 | 0 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 9 | 0 | 5 | 3.8 | CCCN(CCCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL283207 | 99490 | 0 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 9 | 0 | 5 | 3.8 | CCCN(CCCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL52396 | 99490 | 0 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 9 | 0 | 5 | 3.8 | CCCN(CCCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| 10646959 | 40115 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 444 | 9 | 3 | 6 | 3.5 | OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cncn4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL147961 | 40115 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 444 | 9 | 3 | 6 | 3.5 | OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cncn4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| 10321248 | 99426 | 0 | None | - | 1 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 444 | 9 | 0 | 6 | 3.7 | CCCN(CCCON1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL28287 | 99426 | 0 | None | - | 1 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 444 | 9 | 0 | 6 | 3.7 | CCCN(CCCON1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL50722 | 99426 | 0 | None | - | 1 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 444 | 9 | 0 | 6 | 3.7 | CCCN(CCCON1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| 2726 | 919 | 68 | None | -147 | 72 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | |||
| 621 | 919 | 68 | None | -147 | 72 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | |||
| 83 | 919 | 68 | None | -147 | 72 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | |||
| CHEMBL71 | 919 | 68 | None | -147 | 72 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | |||
| DB00477 | 919 | 68 | None | -147 | 72 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | |||
| 10719857 | 202943 | 0 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 363 | 3 | 0 | 4 | 4.0 | C[N+]1(Cc2ccccc2)CCN(c2nc3ccsc3n3cccc23)CC1 | 10.1021/jm950543x | |||
| CHEMBL62911 | 202943 | 0 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 363 | 3 | 0 | 4 | 4.0 | C[N+]1(Cc2ccccc2)CCN(c2nc3ccsc3n3cccc23)CC1 | 10.1021/jm950543x | |||
| 2393 | 3334 | 82 | None | -1 | 5 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10.1021/jm9704558 | |||
| 5078 | 3334 | 82 | None | -1 | 5 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10.1021/jm9704558 | |||
| 51 | 3334 | 82 | None | -1 | 5 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10.1021/jm9704558 | |||
| CHEMBL905 | 3334 | 82 | None | -1 | 5 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10.1021/jm9704558 | |||
| DB00953 | 3334 | 82 | None | -1 | 5 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10.1021/jm9704558 | |||
| 10693140 | 53079 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 414 | 8 | 2 | 5 | 4.0 | C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
| CHEMBL159759 | 53079 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 414 | 8 | 2 | 5 | 4.0 | C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
| 11795644 | 40433 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 406 | 8 | 1 | 5 | 4.0 | CC(C)=CCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| CHEMBL148233 | 40433 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 406 | 8 | 1 | 5 | 4.0 | CC(C)=CCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| 10552243 | 39969 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 468 | 7 | 1 | 5 | 5.4 | c1ccc(C2CCCCN2C2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
| CHEMBL147838 | 39969 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 468 | 7 | 1 | 5 | 5.4 | c1ccc(C2CCCCN2C2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
| 10756517 | 189173 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 298 | 3 | 0 | 5 | 2.9 | C=CCN1CCN(c2nc3sccc3n3cccc23)CC1 | 10.1021/jm950543x | |||
| CHEMBL51118 | 189173 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 298 | 3 | 0 | 5 | 2.9 | C=CCN1CCN(c2nc3sccc3n3cccc23)CC1 | 10.1021/jm950543x | |||
| 10756517 | 189173 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 298 | 3 | 0 | 5 | 2.9 | C=CCN1CCN(c2nc3sccc3n3cccc23)CC1 | 10.1021/jm960501o | |||
| CHEMBL51118 | 189173 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 298 | 3 | 0 | 5 | 2.9 | C=CCN1CCN(c2nc3sccc3n3cccc23)CC1 | 10.1021/jm960501o | |||
| 10550488 | 35655 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 428 | 8 | 2 | 5 | 4.5 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cncn4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL144002 | 35655 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 428 | 8 | 2 | 5 | 4.5 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cncn4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| 161 | 754 | 6 | None | -16 | 6 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 286 | 5 | 2 | 3 | 3.7 | CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N | nan | |||
| 4284720 | 754 | 6 | None | -16 | 6 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 286 | 5 | 2 | 3 | 3.7 | CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N | nan | |||
| CHEMBL1255834 | 754 | 6 | None | -16 | 6 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 286 | 5 | 2 | 3 | 3.7 | CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N | nan | |||
| 10811876 | 102128 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 416 | 3 | 0 | 5 | 5.2 | Clc1ccc(CN2CCN(c3nc4ccsc4n4cccc34)CC2)cc1Cl | 10.1021/jm950543x | |||
| CHEMBL302431 | 102128 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 416 | 3 | 0 | 5 | 5.2 | Clc1ccc(CN2CCN(c3nc4ccsc4n4cccc34)CC2)cc1Cl | 10.1021/jm950543x | |||
| 9949172 | 10873 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 324 | 5 | 1 | 5 | 1.9 | CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9704560 | |||
| CHEMBL117249 | 10873 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 324 | 5 | 1 | 5 | 1.9 | CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9704560 | |||
| 10498554 | 194945 | 0 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 357 | 3 | 0 | 5 | 3.5 | Cc1ccnc2c1nc(N1CCN(Cc3ccccc3)CC1)c1cccn12 | 10.1021/jm960501o | |||
| CHEMBL54246 | 194945 | 0 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 357 | 3 | 0 | 5 | 3.5 | Cc1ccnc2c1nc(N1CCN(Cc3ccccc3)CC1)c1cccn12 | 10.1021/jm960501o | |||
| 10539089 | 51958 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 257 | 3 | 2 | 2 | 2.1 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(C(N)=O)cc32)C1 | 10.1021/jm000956k | |||
| CHEMBL158638 | 51958 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 257 | 3 | 2 | 2 | 2.1 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(C(N)=O)cc32)C1 | 10.1021/jm000956k | |||
| 15222791 | 28560 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 219 | 1 | 1 | 3 | 1.8 | COc1cccc2c1CC1(CCCN1)CO2 | 10.1021/jm950861w | |||
| CHEMBL137643 | 28560 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 219 | 1 | 1 | 3 | 1.8 | COc1cccc2c1CC1(CCCN1)CO2 | 10.1021/jm950861w | |||
| 10574570 | 56232 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 428 | 8 | 1 | 5 | 4.1 | CC(CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm980569z | |||
| CHEMBL162722 | 56232 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 428 | 8 | 1 | 5 | 4.1 | CC(CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm980569z | |||
| 10719203 | 38379 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 471 | 9 | 3 | 6 | 3.9 | CC(=O)Nc1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
| CHEMBL146335 | 38379 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 471 | 9 | 3 | 6 | 3.9 | CC(=O)Nc1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
| 10505438 | 56355 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 496 | 9 | 1 | 8 | 3.9 | Cc1noc(-c2ccc(CCN3CCN(CCCc4c[nH]c5ccc(-n6cnnc6)cc45)CC3)cc2)n1 | 10.1021/jm980569z | |||
| CHEMBL163114 | 56355 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 496 | 9 | 1 | 8 | 3.9 | Cc1noc(-c2ccc(CCN3CCN(CCCc4c[nH]c5ccc(-n6cnnc6)cc45)CC3)cc2)n1 | 10.1021/jm980569z | |||
| 10788207 | 200767 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 419 | 4 | 0 | 4 | 3.4 | CN1C(=O)COc2cc(CCN3CCN(c4cccc(C(F)(F)F)c4)CC3)ccc21 | 10.1021/jm970298c | |||
| CHEMBL60047 | 200767 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 419 | 4 | 0 | 4 | 3.4 | CN1C(=O)COc2cc(CCN3CCN(c4cccc(C(F)(F)F)c4)CC3)ccc21 | 10.1021/jm970298c | |||
| 10552573 | 38141 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 476 | 10 | 4 | 5 | 3.5 | O=C1N[C@@H](Cc2ccc3[nH]cc(CCCN4CCC(N[C@@H](CO)c5ccccc5)CC4)c3c2)CO1 | 10.1021/jm9910021 | |||
| CHEMBL146129 | 38141 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 476 | 10 | 4 | 5 | 3.5 | O=C1N[C@@H](Cc2ccc3[nH]cc(CCCN4CCC(N[C@@H](CO)c5ccccc5)CC4)c3c2)CO1 | 10.1021/jm9910021 | |||
| 10764757 | 44027 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 423 | 6 | 4 | 5 | 3.0 | COc1ccc(NC(=O)NCCc2c[nH]c3ccc(O)cc23)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
| CHEMBL15139 | 44027 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 423 | 6 | 4 | 5 | 3.0 | COc1ccc(NC(=O)NCCc2c[nH]c3ccc(O)cc23)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
| 10645615 | 101001 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 416 | 3 | 0 | 5 | 5.2 | Clc1ccc(CN2CCN(c3nc4ccsc4n4cccc34)CC2)c(Cl)c1 | 10.1021/jm950543x | |||
| CHEMBL294368 | 101001 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 416 | 3 | 0 | 5 | 5.2 | Clc1ccc(CN2CCN(c3nc4ccsc4n4cccc34)CC2)c(Cl)c1 | 10.1021/jm950543x | |||
| 11647963 | 110898 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 444 | 9 | 3 | 6 | 3.3 | OC1(CNCc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
| CHEMBL326125 | 110898 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 444 | 9 | 3 | 6 | 3.3 | OC1(CNCc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
| 10386282 | 164100 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 400 | 8 | 2 | 5 | 3.4 | c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
| CHEMBL420965 | 164100 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 400 | 8 | 2 | 5 | 3.4 | c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
| 10386282 | 164100 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 400 | 8 | 2 | 5 | 3.4 | c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9704558 | |||
| CHEMBL420965 | 164100 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 400 | 8 | 2 | 5 | 3.4 | c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9704558 | |||
| 10811007 | 53145 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 400 | 8 | 2 | 5 | 3.4 | c1ccc(CNC[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
| CHEMBL159819 | 53145 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 400 | 8 | 2 | 5 | 3.4 | c1ccc(CNC[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
| 10386282 | 164100 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 400 | 8 | 2 | 5 | 3.4 | c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
| CHEMBL420965 | 164100 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 400 | 8 | 2 | 5 | 3.4 | c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
| 10503731 | 10289 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 450 | 8 | 1 | 5 | 3.8 | Fc1cc(F)cc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm9704560 | |||
| CHEMBL116153 | 10289 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 450 | 8 | 1 | 5 | 3.8 | Fc1cc(F)cc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm9704560 | |||
| 3117 | 207841 | 103 | None | -3 | 16 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 296 | 4 | 0 | 4 | 3.6 | CCN(CC)C(=S)SSC(=S)N(CC)CC | nan | |||
| CHEMBL964 | 207841 | 103 | None | -3 | 16 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 296 | 4 | 0 | 4 | 3.6 | CCN(CC)C(=S)SSC(=S)N(CC)CC | nan | |||
| 10644749 | 119984 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 401 | 8 | 2 | 6 | 2.8 | c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)nc1 | 10.1021/jm9805687 | |||
| CHEMBL349893 | 119984 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 401 | 8 | 2 | 6 | 2.8 | c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)nc1 | 10.1021/jm9805687 | |||
| 10527882 | 35593 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 458 | 9 | 3 | 6 | 3.9 | C[C@@H](O)[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL143947 | 35593 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 458 | 9 | 3 | 6 | 3.9 | C[C@@H](O)[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| 21138 | 98451 | 39 | None | -162 | 7 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | CC(C)NC[C@@H](O)COc1cccc2ccccc12 | 10.1021/jm00401a007 | |||
| CHEMBL275742 | 98451 | 39 | None | -162 | 7 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | CC(C)NC[C@@H](O)COc1cccc2ccccc12 | 10.1021/jm00401a007 | |||
| 10548259 | 188223 | 0 | None | - | 0 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 387 | 3 | 0 | 7 | 2.9 | c1cnc2c(c1)nc(N1CCN(Cc3ccc4c(c3)OCO4)CC1)c1cccn12 | 10.1021/jm960501o | |||
| CHEMBL49932 | 188223 | 0 | None | - | 0 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 387 | 3 | 0 | 7 | 2.9 | c1cnc2c(c1)nc(N1CCN(Cc3ccc4c(c3)OCO4)CC1)c1cccn12 | 10.1021/jm960501o | |||
| 10252256 | 52777 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 432 | 9 | 3 | 4 | 3.5 | O=C1N[C@@H](Cc2ccc3[nH]cc(CCN4CC[C@@H](CNCc5ccccc5)C4)c3c2)CO1 | 10.1021/jm9805687 | |||
| CHEMBL159483 | 52777 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 432 | 9 | 3 | 4 | 3.5 | O=C1N[C@@H](Cc2ccc3[nH]cc(CCN4CC[C@@H](CNCc5ccccc5)C4)c3c2)CO1 | 10.1021/jm9805687 | |||
| 10252256 | 52777 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 432 | 9 | 3 | 4 | 3.5 | O=C1N[C@@H](Cc2ccc3[nH]cc(CCN4CC[C@@H](CNCc5ccccc5)C4)c3c2)CO1 | 10.1021/jm9805687 | |||
| CHEMBL159483 | 52777 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 432 | 9 | 3 | 4 | 3.5 | O=C1N[C@@H](Cc2ccc3[nH]cc(CCN4CC[C@@H](CNCc5ccccc5)C4)c3c2)CO1 | 10.1021/jm9805687 | |||
| 11797644 | 53423 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 446 | 9 | 3 | 4 | 4.0 | C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(C[C@H]4COC(=O)N4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
| CHEMBL160070 | 53423 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 446 | 9 | 3 | 4 | 4.0 | C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(C[C@H]4COC(=O)N4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
| 10812592 | 100884 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 431 | 8 | 1 | 4 | 5.1 | FC1(CCc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
| CHEMBL293678 | 100884 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 431 | 8 | 1 | 4 | 5.1 | FC1(CCc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
| 15951342 | 125388 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 324 | 3 | 2 | 3 | 3.7 | CN1CCC(c2c[nH]c3ccc(/N=C(\N)c4cccs4)cc23)C1 | nan | |||
| CHEMBL3645479 | 125388 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 324 | 3 | 2 | 3 | 3.7 | CN1CCC(c2c[nH]c3ccc(/N=C(\N)c4cccs4)cc23)C1 | nan | |||
| 5 | 139 | 72 | None | -11 | 54 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00101a032 | |||
| 5202 | 139 | 72 | None | -11 | 54 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00101a032 | |||
| CHEMBL39 | 139 | 72 | None | -11 | 54 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00101a032 | |||
| DB08839 | 139 | 72 | None | -11 | 54 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00101a032 | |||
| 5 | 139 | 72 | None | -13 | 54 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00170a007 | |||
| 5202 | 139 | 72 | None | -13 | 54 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00170a007 | |||
| CHEMBL39 | 139 | 72 | None | -13 | 54 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00170a007 | |||
| DB08839 | 139 | 72 | None | -13 | 54 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00170a007 | |||
| 10670534 | 203436 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 435 | 7 | 1 | 4 | 4.9 | Fc1cccc(CC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | |||
| CHEMBL65765 | 203436 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 435 | 7 | 1 | 4 | 4.9 | Fc1cccc(CC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | |||
| 11797644 | 53423 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 446 | 9 | 3 | 4 | 4.0 | C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(C[C@H]4COC(=O)N4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
| CHEMBL160070 | 53423 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 446 | 9 | 3 | 4 | 4.0 | C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(C[C@H]4COC(=O)N4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
| 10811007 | 53145 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 400 | 8 | 2 | 5 | 3.4 | c1ccc(CNC[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9704558 | |||
| CHEMBL159819 | 53145 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 400 | 8 | 2 | 5 | 3.4 | c1ccc(CNC[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9704558 | |||
| 9824884 | 51859 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 447 | 4 | 2 | 4 | 4.3 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccccc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
| CHEMBL15855 | 51859 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 447 | 4 | 2 | 4 | 4.3 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccccc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
| 10412190 | 52918 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 465 | 4 | 2 | 4 | 4.5 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4cccc(F)c34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
| CHEMBL15961 | 52918 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 465 | 4 | 2 | 4 | 4.5 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4cccc(F)c34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
| 49836496 | 18555 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 246 | 2 | 1 | 1 | 3.5 | CN(C)[C@H]1CC[C@@H](c2c[nH]c3ccc(F)cc23)C1 | 10.1021/jm100515z | |||
| CHEMBL1275791 | 18555 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 246 | 2 | 1 | 1 | 3.5 | CN(C)[C@H]1CC[C@@H](c2c[nH]c3ccc(F)cc23)C1 | 10.1021/jm100515z | |||
| 121852 | 10166 | 7 | None | - | 1 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL11592 | 10166 | 7 | None | - | 1 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL301060 | 10166 | 7 | None | - | 1 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| 121852 | 10166 | 7 | None | - | 1 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm950861w | |||
| CHEMBL11592 | 10166 | 7 | None | - | 1 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm950861w | |||
| CHEMBL301060 | 10166 | 7 | None | - | 1 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm950861w | |||
| 4223 | 3992 | 94 | None | - | 3 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | |||
| 6918314 | 3992 | 94 | None | - | 3 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | |||
| 7427 | 3992 | 94 | None | - | 3 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | |||
| CHEMBL439849 | 3992 | 94 | None | - | 3 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | |||
| DB06684 | 3992 | 94 | None | - | 3 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | |||
| 42 | 2063 | 57 | None | -1778 | 18 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00038a007 | |||
| 56971 | 2063 | 57 | None | -1778 | 18 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00038a007 | |||
| CHEMBL8412 | 2063 | 57 | None | -1778 | 18 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00038a007 | |||
| 10338595 | 162499 | 0 | None | - | 1 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 360 | 9 | 0 | 4 | 4.0 | CCCN(CCCCN1CCCCC1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL416747 | 162499 | 0 | None | - | 1 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 360 | 9 | 0 | 4 | 4.0 | CCCN(CCCCN1CCCCC1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| 42 | 2063 | 57 | None | -1778 | 18 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm950861w | |||
| 56971 | 2063 | 57 | None | -1778 | 18 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm950861w | |||
| CHEMBL8412 | 2063 | 57 | None | -1778 | 18 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm950861w | |||
| 23786480 | 15263 | 2 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 386 | 7 | 1 | 5 | 2.9 | O=C1CC2(CCCC2)CC(=O)N1CCCCNC[C@@H]1COc2ccccc2O1 | 10.1021/jm00401a007 | |||
| CHEMBL12124 | 15263 | 2 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 386 | 7 | 1 | 5 | 2.9 | O=C1CC2(CCCC2)CC(=O)N1CCCCNC[C@@H]1COc2ccccc2O1 | 10.1021/jm00401a007 | |||
| 121852 | 10166 | 7 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1016/0960-894X(96)00174-6 | |||
| CHEMBL11592 | 10166 | 7 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1016/0960-894X(96)00174-6 | |||
| CHEMBL301060 | 10166 | 7 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1016/0960-894X(96)00174-6 | |||
| 115 | 3791 | 80 | None | 1 | 27 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 10.1021/jm00123a039 | |||
| 4296 | 3791 | 80 | None | 1 | 27 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 10.1021/jm00123a039 | |||
| CHEMBL274866 | 3791 | 80 | None | 1 | 27 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 10.1021/jm00123a039 | |||
| 3082597 | 99559 | 8 | None | - | 1 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 263 | 6 | 0 | 3 | 3.1 | CCCN(CCC)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL283606 | 99559 | 8 | None | - | 1 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 263 | 6 | 0 | 3 | 3.1 | CCCN(CCC)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| 10759465 | 164895 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 338 | 6 | 1 | 5 | 2.3 | CN1CCN(CCCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
| CHEMBL422191 | 164895 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 338 | 6 | 1 | 5 | 2.3 | CN1CCN(CCCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
| 10527884 | 28374 | 0 | None | - | 0 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 3.9 | COc1cccc2c1CC1(CCCCN1CCCCNS(=O)(=O)c1ccc(C)cc1)CO2 | 10.1021/jm950861w | |||
| CHEMBL137486 | 28374 | 0 | None | - | 0 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 3.9 | COc1cccc2c1CC1(CCCCN1CCCCNS(=O)(=O)c1ccc(C)cc1)CO2 | 10.1021/jm950861w | |||
| 10551525 | 100670 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 450 | 8 | 1 | 5 | 3.6 | Fc1ccccc1CCN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
| CHEMBL292262 | 100670 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 450 | 8 | 1 | 5 | 3.6 | Fc1ccccc1CCN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm981133m | |||
| 10618751 | 35190 | 0 | None | -4 | 4 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 364 | 7 | 1 | 4 | 3.3 | CCN(CC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
| CHEMBL143510 | 35190 | 0 | None | -4 | 4 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 364 | 7 | 1 | 4 | 3.3 | CCN(CC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
| 10623434 | 102312 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 450 | 8 | 1 | 5 | 3.6 | Fc1ccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm981133m | |||
| CHEMBL303514 | 102312 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 450 | 8 | 1 | 5 | 3.6 | Fc1ccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm981133m | |||
| 44341637 | 9601 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 445 | 9 | 3 | 7 | 2.7 | OC1(CNCc2ccccn2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
| CHEMBL112558 | 9601 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 445 | 9 | 3 | 7 | 2.7 | OC1(CNCc2ccccn2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
| 44214559 | 56498 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 443 | 8 | 2 | 6 | 2.5 | NC(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
| CHEMBL163462 | 56498 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 443 | 8 | 2 | 6 | 2.5 | NC(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
| 145 | 140 | 49 | None | -8 | 30 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00101a032 | |||
| 1832 | 140 | 49 | None | -8 | 30 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00101a032 | |||
| CHEMBL7257 | 140 | 49 | None | -8 | 30 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00101a032 | |||
| DB14010 | 140 | 49 | None | -8 | 30 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00101a032 | |||
| 3081681 | 98514 | 4 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 442 | 6 | 0 | 7 | 3.4 | O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(c2nsc3ccccc23)CC1 | 10.1021/jm00107a028 | |||
| CHEMBL276175 | 98514 | 4 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 442 | 6 | 0 | 7 | 3.4 | O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(c2nsc3ccccc23)CC1 | 10.1021/jm00107a028 | |||
| 9890331 | 56367 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 457 | 8 | 2 | 6 | 3.5 | CC(=O)Nc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
| CHEMBL163127 | 56367 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 457 | 8 | 2 | 6 | 3.5 | CC(=O)Nc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
| 18366015 | 78372 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 313 | 4 | 2 | 3 | 2.6 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1 | 10.1021/jm000956k | |||
| CHEMBL2110300 | 78372 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 313 | 4 | 2 | 3 | 2.6 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1 | 10.1021/jm000956k | |||
| 10666301 | 193436 | 0 | None | - | 0 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 361 | 3 | 0 | 5 | 3.3 | Fc1ccc(CN2CCN(c3nc4cccnc4n4cccc34)CC2)cc1 | 10.1021/jm960501o | |||
| CHEMBL52625 | 193436 | 0 | None | - | 0 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 361 | 3 | 0 | 5 | 3.3 | Fc1ccc(CN2CCN(c3nc4cccnc4n4cccc34)CC2)cc1 | 10.1021/jm960501o | |||
| 10646633 | 51282 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 437 | 3 | 2 | 4 | 3.7 | COc1ccc(NC(=O)N2CCc3[nH]c4ccc(F)cc4c3C2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
| CHEMBL15808 | 51282 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 437 | 3 | 2 | 4 | 3.7 | COc1ccc(NC(=O)N2CCc3[nH]c4ccc(F)cc4c3C2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
| 44344504 | 112832 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 295 | 4 | 1 | 4 | 2.8 | c1cc2[nH]cc(CCN3CCCCC3)c2cc1-n1cnnc1 | 10.1021/jm9704558 | |||
| CHEMBL330803 | 112832 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 295 | 4 | 1 | 4 | 2.8 | c1cc2[nH]cc(CCN3CCCCC3)c2cc1-n1cnnc1 | 10.1021/jm9704558 | |||
| 44341657 | 113057 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 408 | 9 | 3 | 6 | 2.5 | OC1(CNCC2CC2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
| CHEMBL331143 | 113057 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 408 | 9 | 3 | 6 | 2.5 | OC1(CNCC2CC2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
| 73347307 | 89698 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 257 | 2 | 2 | 3 | 2.8 | Cc1[nH]c2ccc([N+](=O)[O-])cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
| CHEMBL2376487 | 89698 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 257 | 2 | 2 | 3 | 2.8 | Cc1[nH]c2ccc([N+](=O)[O-])cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
| 44344504 | 112832 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 295 | 4 | 1 | 4 | 2.8 | c1cc2[nH]cc(CCN3CCCCC3)c2cc1-n1cnnc1 | 10.1021/jm9805687 | |||
| CHEMBL330803 | 112832 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 295 | 4 | 1 | 4 | 2.8 | c1cc2[nH]cc(CCN3CCCCC3)c2cc1-n1cnnc1 | 10.1021/jm9805687 | |||
| 10834908 | 52665 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 401 | 8 | 1 | 5 | 4.0 | c1ccc(COC[C@H]2CCCN2CCc2c[nH]c3ccc(-n4cnnc4)cc23)cc1 | 10.1021/jm9805687 | |||
| CHEMBL159381 | 52665 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 401 | 8 | 1 | 5 | 4.0 | c1ccc(COC[C@H]2CCCN2CCc2c[nH]c3ccc(-n4cnnc4)cc23)cc1 | 10.1021/jm9805687 | |||
| 11796808 | 53053 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 428 | 9 | 1 | 5 | 3.8 | CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1 | 10.1021/jm9805687 | |||
| CHEMBL159733 | 53053 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 428 | 9 | 1 | 5 | 3.8 | CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1 | 10.1021/jm9805687 | |||
| 10590206 | 202803 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 298 | 3 | 0 | 5 | 2.9 | C=CCN1CCN(c2nc3ccsc3n3cccc23)CC1 | 10.1021/jm950543x | |||
| CHEMBL62274 | 202803 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 298 | 3 | 0 | 5 | 2.9 | C=CCN1CCN(c2nc3ccsc3n3cccc23)CC1 | 10.1021/jm950543x | |||
| 10646873 | 38448 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 442 | 9 | 2 | 5 | 4.7 | C[C@H](NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL146391 | 38448 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 442 | 9 | 2 | 5 | 4.7 | C[C@H](NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| 10105889 | 24183 | 1 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 244 | 3 | 1 | 2 | 2.8 | COc1ccc2[nH]cc(C[C@@H]3CCCN3C)c2c1 | 10.1021/jm00101a032 | |||
| CHEMBL133939 | 24183 | 1 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 244 | 3 | 1 | 2 | 2.8 | COc1ccc2[nH]cc(C[C@@H]3CCCN3C)c2c1 | 10.1021/jm00101a032 | |||
| 10694810 | 203767 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 449 | 8 | 1 | 4 | 5.3 | FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(CCc2ccccc2)CC1 | 10.1021/jm981133m | |||
| CHEMBL68019 | 203767 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 449 | 8 | 1 | 4 | 5.3 | FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(CCc2ccccc2)CC1 | 10.1021/jm981133m | |||
| 11797241 | 194354 | 0 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 437 | 3 | 0 | 7 | 4.1 | c1cnc2ccc3nc(N4CCN(Cc5ccc6c(c5)OCO6)CC4)c4cccn4c3c2c1 | 10.1021/jm960501o | |||
| CHEMBL52867 | 194354 | 0 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 437 | 3 | 0 | 7 | 4.1 | c1cnc2ccc3nc(N4CCN(Cc5ccc6c(c5)OCO6)CC4)c4cccn4c3c2c1 | 10.1021/jm960501o | |||
| 10741528 | 55111 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 434 | 7 | 1 | 5 | 4.2 | Clc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
| CHEMBL161696 | 55111 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 434 | 7 | 1 | 5 | 4.2 | Clc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
| 10836301 | 52964 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 428 | 9 | 1 | 5 | 4.1 | CN(Cc1ccccc1)C[C@@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9805687 | |||
| CHEMBL159650 | 52964 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 428 | 9 | 1 | 5 | 4.1 | CN(Cc1ccccc1)C[C@@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9805687 | |||
| 108029 | 3414 | 57 | None | -3 | 13 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 228 | 2 | 2 | 2 | 2.6 | COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
| 23 | 3414 | 57 | None | -3 | 13 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 228 | 2 | 2 | 2 | 2.6 | COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
| CHEMBL18785 | 3414 | 57 | None | -3 | 13 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 228 | 2 | 2 | 2 | 2.6 | COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
| 2869 | 4152 | 89 | None | -8 | 7 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1021/jm000956k | |||
| 60 | 4152 | 89 | None | -8 | 7 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1021/jm000956k | |||
| 60857 | 4152 | 89 | None | -8 | 7 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1021/jm000956k | |||
| CHEMBL1185 | 4152 | 89 | None | -8 | 7 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1021/jm000956k | |||
| DB00315 | 4152 | 89 | None | -8 | 7 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1021/jm000956k | |||
| 10528410 | 39382 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 471 | 8 | 2 | 5 | 4.6 | CN(CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)C(=O)Nc1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL147148 | 39382 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 471 | 8 | 2 | 5 | 4.6 | CN(CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)C(=O)Nc1ccccc1 | 10.1021/jm9910021 | |||
| 10624680 | 122018 | 17 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 483 | 5 | 2 | 7 | 4.7 | Cc1nnc(-c2ccc(-c3ccc(C(=O)Nc4ccc(O)c(N5CCN(C)CC5)c4)cc3)c(C)c2)o1 | 10.1021/jm990397l | |||
| CHEMBL359447 | 122018 | 17 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 483 | 5 | 2 | 7 | 4.7 | Cc1nnc(-c2ccc(-c3ccc(C(=O)Nc4ccc(O)c(N5CCN(C)CC5)c4)cc3)c(C)c2)o1 | 10.1021/jm990397l | |||
| 5 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2013.01.044 | |||
| 5202 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2013.01.044 | |||
| CHEMBL39 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2013.01.044 | |||
| DB08839 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2013.01.044 | |||
| 10719448 | 35603 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 478 | 9 | 2 | 6 | 3.4 | O=S(=O)(NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL143952 | 35603 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 478 | 9 | 2 | 6 | 3.4 | O=S(=O)(NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| 10673854 | 44452 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 533 | 7 | 1 | 8 | 4.6 | COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(-c4nnc(C)o4)cc3C)cc2)cc1N1CCN(C)CC1 | 10.1021/jm990397l | |||
| CHEMBL151894 | 44452 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 533 | 7 | 1 | 8 | 4.6 | COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(-c4nnc(C)o4)cc3C)cc2)cc1N1CCN(C)CC1 | 10.1021/jm990397l | |||
| 10645076 | 200310 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 407 | 4 | 1 | 5 | 4.4 | Oc1nc2ccc(CCN3CCN(c4cccc(C(F)(F)F)c4)CC3)cc2s1 | 10.1021/jm970298c | |||
| CHEMBL59741 | 200310 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 407 | 4 | 1 | 5 | 4.4 | Oc1nc2ccc(CCN3CCN(c4cccc(C(F)(F)F)c4)CC3)cc2s1 | 10.1021/jm970298c | |||
| 121852 | 10166 | 7 | None | - | 1 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL11592 | 10166 | 7 | None | - | 1 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL301060 | 10166 | 7 | None | - | 1 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| 121852 | 10166 | 7 | None | - | 1 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm950861w | |||
| CHEMBL11592 | 10166 | 7 | None | - | 1 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm950861w | |||
| CHEMBL301060 | 10166 | 7 | None | - | 1 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 442 | 9 | 0 | 5 | 4.2 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1 | 10.1021/jm950861w | |||
| 10040815 | 97060 | 0 | None | - | 1 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 306 | 7 | 1 | 4 | 1.8 | CCCN(CCNC(C)=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL264027 | 97060 | 0 | None | - | 1 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 306 | 7 | 1 | 4 | 1.8 | CCCN(CCNC(C)=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL26715 | 97060 | 0 | None | - | 1 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 306 | 7 | 1 | 4 | 1.8 | CCCN(CCNC(C)=O)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| 15516683 | 10072 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 438 | 8 | 2 | 6 | 3.5 | CN(CC(C)(C)C)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
| CHEMBL115352 | 10072 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 438 | 8 | 2 | 6 | 3.5 | CN(CC(C)(C)C)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
| 10691383 | 100775 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 383 | 6 | 1 | 6 | 3.8 | COc1ccccc1N1CCN(CCCc2ccc3nc(O)sc3c2)CC1 | 10.1021/jm970298c | |||
| CHEMBL292935 | 100775 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 383 | 6 | 1 | 6 | 3.8 | COc1ccccc1N1CCN(CCCc2ccc3nc(O)sc3c2)CC1 | 10.1021/jm970298c | |||
| 25070577 | 111666 | 4 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 304 | 3 | 2 | 4 | 2.3 | CNc1nc(C(F)(F)c2ccccc2)nc2c1CCNCC2 | 10.1021/jm5003292 | |||
| CHEMBL3286557 | 111666 | 4 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 304 | 3 | 2 | 4 | 2.3 | CNc1nc(C(F)(F)c2ccccc2)nc2c1CCNCC2 | 10.1021/jm5003292 | |||
| 9867902 | 55219 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 440 | 10 | 3 | 4 | 2.9 | CNS(=O)(=O)Cc1ccc2[nH]cc(CCN3CC[C@@H](CNCc4ccccc4)C3)c2c1 | 10.1021/jm9805687 | |||
| CHEMBL161780 | 55219 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 440 | 10 | 3 | 4 | 2.9 | CNS(=O)(=O)Cc1ccc2[nH]cc(CCN3CC[C@@H](CNCc4ccccc4)C3)c2c1 | 10.1021/jm9805687 | |||
| 9867902 | 55219 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 440 | 10 | 3 | 4 | 2.9 | CNS(=O)(=O)Cc1ccc2[nH]cc(CCN3CC[C@@H](CNCc4ccccc4)C3)c2c1 | 10.1021/jm9805687 | |||
| CHEMBL161780 | 55219 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 440 | 10 | 3 | 4 | 2.9 | CNS(=O)(=O)Cc1ccc2[nH]cc(CCN3CC[C@@H](CNCc4ccccc4)C3)c2c1 | 10.1021/jm9805687 | |||
| 10525100 | 119521 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 401 | 8 | 2 | 6 | 2.8 | c1cncc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)c1 | 10.1021/jm9805687 | |||
| CHEMBL345657 | 119521 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 401 | 8 | 2 | 6 | 2.8 | c1cncc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)c1 | 10.1021/jm9805687 | |||
| 10341917 | 168049 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 417 | 7 | 1 | 4 | 4.6 | FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm981133m | |||
| CHEMBL432332 | 168049 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 417 | 7 | 1 | 4 | 4.6 | FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm981133m | |||
| 10502495 | 53715 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 425 | 6 | 3 | 4 | 3.4 | COc1ccc(NC(=O)NCCc2c[nH]c3ccc(F)cc23)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
| CHEMBL16035 | 53715 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 425 | 6 | 3 | 4 | 3.4 | COc1ccc(NC(=O)NCCc2c[nH]c3ccc(F)cc23)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
| 10592083 | 35601 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 324 | 5 | 2 | 5 | 2.1 | NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| CHEMBL143951 | 35601 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 324 | 5 | 2 | 5 | 2.1 | NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| 182585 | 15447 | 15 | None | -1 | 4 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 386 | 7 | 1 | 5 | 2.9 | O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COc2ccccc2O1 | 10.1021/jm00401a007 | |||
| CHEMBL12152 | 15447 | 15 | None | -1 | 4 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 386 | 7 | 1 | 5 | 2.9 | O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COc2ccccc2O1 | 10.1021/jm00401a007 | |||
| 10782381 | 89273 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 326 | 4 | 2 | 3 | 2.0 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CN4C(=O)CNC4=O)cc32)C1 | 10.1021/jm000956k | |||
| CHEMBL2368258 | 89273 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 326 | 4 | 2 | 3 | 2.0 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CN4C(=O)CNC4=O)cc32)C1 | 10.1021/jm000956k | |||
| 10598044 | 203294 | 0 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 416 | 3 | 0 | 5 | 5.2 | Clc1ccc(CN2CCN(c3nc4sccc4n4cccc34)CC2)c(Cl)c1 | 10.1021/jm950543x | |||
| CHEMBL64727 | 203294 | 0 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 416 | 3 | 0 | 5 | 5.2 | Clc1ccc(CN2CCN(c3nc4sccc4n4cccc34)CC2)c(Cl)c1 | 10.1021/jm950543x | |||
| 10551680 | 99044 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 454 | 7 | 2 | 4 | 4.7 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(F)cc34)CC2)cc1OCCN(C)C | 10.1021/jm9811054 | |||
| CHEMBL280314 | 99044 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 454 | 7 | 2 | 4 | 4.7 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(F)cc34)CC2)cc1OCCN(C)C | 10.1021/jm9811054 | |||
| 10833258 | 96418 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 374 | 4 | 0 | 5 | 4.4 | C(=C/c1ccccc1)\CN1CCN(c2nc3ccsc3n3cccc23)CC1 | 10.1021/jm950543x | |||
| CHEMBL261977 | 96418 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 374 | 4 | 0 | 5 | 4.4 | C(=C/c1ccccc1)\CN1CCN(c2nc3ccsc3n3cccc23)CC1 | 10.1021/jm950543x | |||
| 1524 | 2181 | 96 | None | -2511 | 52 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm9704558 | |||
| 197 | 2181 | 96 | None | -2511 | 52 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm9704558 | |||
| 3822 | 2181 | 96 | None | -2511 | 52 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm9704558 | |||
| 88 | 2181 | 96 | None | -2511 | 52 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm9704558 | |||
| CHEMBL51 | 2181 | 96 | None | -2511 | 52 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm9704558 | |||
| DB12465 | 2181 | 96 | None | -2511 | 52 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm9704558 | |||
| 10839082 | 39713 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 499 | 10 | 2 | 6 | 4.3 | CC(=O)Nc1ccc(CCN(C)C2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
| CHEMBL147546 | 39713 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 499 | 10 | 2 | 6 | 4.3 | CC(=O)Nc1ccc(CCN(C)C2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
| 10602052 | 119265 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 520 | 10 | 1 | 7 | 3.9 | CN(Cc1ccc(S(C)(=O)=O)cc1)CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| CHEMBL343667 | 119265 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 520 | 10 | 1 | 7 | 3.9 | CN(Cc1ccc(S(C)(=O)=O)cc1)CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| 10691904 | 35620 | 0 | None | -6 | 4 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 392 | 9 | 1 | 4 | 4.1 | CCCN(CCC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
| CHEMBL143967 | 35620 | 0 | None | -6 | 4 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 392 | 9 | 1 | 4 | 4.1 | CCCN(CCC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
| 9911120 | 9623 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 440 | 6 | 0 | 5 | 4.0 | COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1016/0960-894X(96)00174-6 | |||
| CHEMBL11265 | 9623 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 440 | 6 | 0 | 5 | 4.0 | COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2 | 10.1016/0960-894X(96)00174-6 | |||
| 10569470 | 100912 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 344 | 4 | 0 | 7 | 2.2 | CCOC(=O)CN1CCN(c2nc3ccsc3n3cccc23)CC1 | 10.1021/jm950543x | |||
| CHEMBL293879 | 100912 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 344 | 4 | 0 | 7 | 2.2 | CCOC(=O)CN1CCN(c2nc3ccsc3n3cccc23)CC1 | 10.1021/jm950543x | |||
| 10789717 | 79526 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 450 | 8 | 1 | 5 | 3.6 | Fc1cccc(CCN2CCN(C[C@@H](F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | |||
| CHEMBL2114036 | 79526 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 450 | 8 | 1 | 5 | 3.6 | Fc1cccc(CCN2CCN(C[C@@H](F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm981133m | |||
| 10600063 | 120011 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 460 | 9 | 1 | 4 | 4.2 | CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(C[C@H]4COC(=O)N4C)cc23)C1 | 10.1021/jm9805687 | |||
| CHEMBL350153 | 120011 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 460 | 9 | 1 | 4 | 4.2 | CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(C[C@H]4COC(=O)N4C)cc23)C1 | 10.1021/jm9805687 | |||
| 10707563 | 28355 | 0 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 275 | 3 | 0 | 3 | 3.3 | CCCN1CCCCC12COc1cccc(OC)c1C2 | 10.1021/jm950861w | |||
| CHEMBL137478 | 28355 | 0 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 275 | 3 | 0 | 3 | 3.3 | CCCN1CCCCC12COc1cccc(OC)c1C2 | 10.1021/jm950861w | |||
| 10091430 | 9881 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 384 | 7 | 1 | 4 | 3.3 | O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COc2ccccc2C1 | 10.1016/0960-894X(96)00174-6 | |||
| CHEMBL11425 | 9881 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 384 | 7 | 1 | 4 | 3.3 | O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COc2ccccc2C1 | 10.1016/0960-894X(96)00174-6 | |||
| 10452995 | 194746 | 0 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 390 | 4 | 0 | 5 | 4.0 | COc1ccc2c(c1)nc(N1CCN(Cc3ccc(F)cc3)CC1)c1cccn12 | 10.1021/jm960501o | |||
| CHEMBL53662 | 194746 | 0 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 390 | 4 | 0 | 5 | 4.0 | COc1ccc2c(c1)nc(N1CCN(Cc3ccc(F)cc3)CC1)c1cccn12 | 10.1021/jm960501o | |||
| 10600871 | 164950 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 483 | 5 | 2 | 7 | 4.7 | Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc(O)c(N5CCN(C)CC5)c4)cc3)c(C)c2)no1 | 10.1021/jm990397l | |||
| CHEMBL422504 | 164950 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 483 | 5 | 2 | 7 | 4.7 | Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc(O)c(N5CCN(C)CC5)c4)cc3)c(C)c2)no1 | 10.1021/jm990397l | |||
| 10733823 | 56280 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 311 | 5 | 1 | 5 | 2.0 | c1cc2[nH]cc(CCCN3CCOCC3)c2cc1-n1cnnc1 | 10.1021/jm980569z | |||
| CHEMBL162930 | 56280 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 311 | 5 | 1 | 5 | 2.0 | c1cc2[nH]cc(CCCN3CCOCC3)c2cc1-n1cnnc1 | 10.1021/jm980569z | |||
| 10717072 | 163243 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 421 | 4 | 0 | 5 | 4.0 | Cn1c(=O)sc2cc(CCN3CCN(c4cccc(C(F)(F)F)c4)CC3)ccc21 | 10.1021/jm970298c | |||
| CHEMBL418499 | 163243 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 421 | 4 | 0 | 5 | 4.0 | Cn1c(=O)sc2cc(CCN3CCN(c4cccc(C(F)(F)F)c4)CC3)ccc21 | 10.1021/jm970298c | |||
| 10530932 | 169678 | 15 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 561 | 7 | 1 | 9 | 4.4 | Cc1nnc(-c2ccc(-c3ccc(C(=O)Nc4ccc(OS(C)(=O)=O)c(N5CCN(C)CC5)c4)cc3)c(C)c2)o1 | 10.1021/jm990397l | |||
| CHEMBL443762 | 169678 | 15 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 561 | 7 | 1 | 9 | 4.4 | Cc1nnc(-c2ccc(-c3ccc(C(=O)Nc4ccc(OS(C)(=O)=O)c(N5CCN(C)CC5)c4)cc3)c(C)c2)o1 | 10.1021/jm990397l | |||
| 9981671 | 14541 | 0 | None | - | 1 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 459 | 7 | 1 | 9 | 3.1 | COc1ccccc1N1CCN(CCCSc2nc3sc(C)c(C)c3c(=O)n2N)CC1 | 10.1021/jm950866t | |||
| CHEMBL12028 | 14541 | 0 | None | - | 1 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 459 | 7 | 1 | 9 | 3.1 | COc1ccccc1N1CCN(CCCSc2nc3sc(C)c(C)c3c(=O)n2N)CC1 | 10.1021/jm950866t | |||
| 10627612 | 44245 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 615 | 7 | 1 | 9 | 5.3 | Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc(OS(=O)(=O)C(F)(F)F)c(N5CCN(C)CC5)c4)cc3)c(C)c2)no1 | 10.1021/jm990397l | |||
| CHEMBL151695 | 44245 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 615 | 7 | 1 | 9 | 5.3 | Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc(OS(=O)(=O)C(F)(F)F)c(N5CCN(C)CC5)c4)cc3)c(C)c2)no1 | 10.1021/jm990397l | |||
| 10429859 | 12042 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 380 | 7 | 1 | 5 | 2.7 | COc1cccc2c1CC(NCCCCN1C(=O)c3ccccc3C1=O)CO2 | 10.1021/jm00038a007 | |||
| CHEMBL1183429 | 12042 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 380 | 7 | 1 | 5 | 2.7 | COc1cccc2c1CC(NCCCCN1C(=O)c3ccccc3C1=O)CO2 | 10.1021/jm00038a007 | |||
| CHEMBL296395 | 12042 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 380 | 7 | 1 | 5 | 2.7 | COc1cccc2c1CC(NCCCCN1C(=O)c3ccccc3C1=O)CO2 | 10.1021/jm00038a007 | |||
| 135398745 | 2914 | 112 | None | -162 | 65 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | nan | |||
| 47 | 2914 | 112 | None | -162 | 65 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | nan | |||
| CHEMBL715 | 2914 | 112 | None | -162 | 65 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | nan | |||
| DB00334 | 2914 | 112 | None | -162 | 65 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | nan | |||
| 173 | 3262 | 95 | None | -2 | 23 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm950543x | |||
| 5011 | 3262 | 95 | None | -2 | 23 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm950543x | |||
| CHEMBL18772 | 3262 | 95 | None | -2 | 23 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm950543x | |||
| 10739272 | 100739 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 392 | 3 | 0 | 7 | 3.6 | c1cc2c(N3CCN(Cc4ccc5c(c4)OCO5)CC3)nc3sccc3n2c1 | 10.1021/jm950543x | |||
| CHEMBL292725 | 100739 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 392 | 3 | 0 | 7 | 3.6 | c1cc2c(N3CCN(Cc4ccc5c(c4)OCO5)CC3)nc3sccc3n2c1 | 10.1021/jm950543x | |||
| 173 | 3262 | 95 | None | -2 | 23 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm960501o | |||
| 5011 | 3262 | 95 | None | -2 | 23 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm960501o | |||
| CHEMBL18772 | 3262 | 95 | None | -2 | 23 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm960501o | |||
| 10689339 | 203091 | 0 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 352 | 2 | 0 | 5 | 4.0 | Fc1ccc(N2CCN(c3nc4ccsc4n4cccc34)CC2)cc1 | 10.1021/jm950543x | |||
| CHEMBL63905 | 203091 | 0 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 352 | 2 | 0 | 5 | 4.0 | Fc1ccc(N2CCN(c3nc4ccsc4n4cccc34)CC2)cc1 | 10.1021/jm950543x | |||
| 10714509 | 101589 | 0 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 375 | 3 | 0 | 5 | 3.7 | Cc1ccnc2c1nc(N1CCN(Cc3ccc(F)cc3)CC1)c1cccn12 | 10.1021/jm960501o | |||
| CHEMBL298649 | 101589 | 0 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 375 | 3 | 0 | 5 | 3.7 | Cc1ccnc2c1nc(N1CCN(Cc3ccc(F)cc3)CC1)c1cccn12 | 10.1021/jm960501o | |||
| 11059058 | 10091 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 429 | 3 | 1 | 7 | 4.1 | O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1 | 10.1021/jm010878g | |||
| CHEMBL115444 | 10091 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 429 | 3 | 1 | 7 | 4.1 | O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1 | 10.1021/jm010878g | |||
| 10504096 | 118935 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 458 | 9 | 2 | 6 | 3.8 | CN(C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@H](CO)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL342330 | 118935 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 458 | 9 | 2 | 6 | 3.8 | CN(C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@H](CO)c1ccccc1 | 10.1021/jm9910021 | |||
| 114 | 2254 | 14 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm980569z | |||
| 6426760 | 2254 | 14 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm980569z | |||
| CHEMBL292779 | 2254 | 14 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm980569z | |||
| 114 | 2254 | 14 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm981133m | |||
| 6426760 | 2254 | 14 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm981133m | |||
| CHEMBL292779 | 2254 | 14 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm981133m | |||
| 10694895 | 102445 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 451 | 8 | 1 | 5 | 4.7 | FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(COc2ccccc2)CC1 | 10.1021/jm981133m | |||
| CHEMBL303997 | 102445 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 451 | 8 | 1 | 5 | 4.7 | FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(COc2ccccc2)CC1 | 10.1021/jm981133m | |||
| 10501945 | 54934 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 414 | 8 | 2 | 5 | 4.0 | C[C@@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
| CHEMBL161410 | 54934 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 414 | 8 | 2 | 5 | 4.0 | C[C@@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1 | 10.1021/jm9805687 | |||
| 10741826 | 39199 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 441 | 6 | 2 | 7 | 4.1 | Oc1nc2ccccc2n1C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| CHEMBL146991 | 39199 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 441 | 6 | 2 | 7 | 4.1 | Oc1nc2ccccc2n1C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| 10573164 | 203084 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 402 | 2 | 0 | 5 | 4.9 | FC(F)(F)c1cccc(N2CCN(c3nc4sccc4n4cccc34)CC2)c1 | 10.1021/jm950543x | |||
| CHEMBL63845 | 203084 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 402 | 2 | 0 | 5 | 4.9 | FC(F)(F)c1cccc(N2CCN(c3nc4sccc4n4cccc34)CC2)c1 | 10.1021/jm950543x | |||
| 44267161 | 163042 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 456 | 10 | 0 | 5 | 4.4 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)CC1COc2cccc(OC)c2C1 | 10.1016/0960-894X(96)00174-6 | |||
| CHEMBL417608 | 163042 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 456 | 10 | 0 | 5 | 4.4 | CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)CC1COc2cccc(OC)c2C1 | 10.1016/0960-894X(96)00174-6 | |||
| 114 | 2254 | 14 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9704560 | |||
| 6426760 | 2254 | 14 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9704560 | |||
| CHEMBL292779 | 2254 | 14 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9704560 | |||
| 73354882 | 89693 | 1 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 290 | 1 | 2 | 1 | 3.6 | Cc1[nH]c2ccc(Br)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
| CHEMBL2376482 | 89693 | 1 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 290 | 1 | 2 | 1 | 3.6 | Cc1[nH]c2ccc(Br)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
| 114 | 2254 | 14 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9704560 | |||
| 6426760 | 2254 | 14 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9704560 | |||
| CHEMBL292779 | 2254 | 14 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9704560 | |||
| 10693207 | 37981 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 415 | 8 | 2 | 6 | 3.3 | c1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1 | 10.1021/jm9910021 | |||
| CHEMBL145997 | 37981 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 415 | 8 | 2 | 6 | 3.3 | c1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1 | 10.1021/jm9910021 | |||
| 10530035 | 51632 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 522 | 8 | 2 | 5 | 4.2 | COc1ccc(NC(=O)N2CCN(CCCCc3c[nH]c4ccc(F)cc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
| CHEMBL15837 | 51632 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 522 | 8 | 2 | 5 | 4.2 | COc1ccc(NC(=O)N2CCN(CCCCc3c[nH]c4ccc(F)cc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
| 10645335 | 188713 | 0 | None | - | 0 | Rat | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 411 | 3 | 0 | 5 | 4.5 | Clc1ccc(CN2CCN(c3nc4cccnc4n4cccc34)CC2)c(Cl)c1 | 10.1021/jm960501o | |||
| CHEMBL50456 | 188713 | 0 | None | - | 0 | Rat | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 411 | 3 | 0 | 5 | 4.5 | Clc1ccc(CN2CCN(c3nc4cccnc4n4cccc34)CC2)c(Cl)c1 | 10.1021/jm960501o | |||
| 10768329 | 40248 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 521 | 11 | 3 | 7 | 3.0 | CS(=O)(=O)NC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL148071 | 40248 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 521 | 11 | 3 | 7 | 3.0 | CS(=O)(=O)NC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| 10836290 | 55437 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 428 | 8 | 1 | 5 | 3.1 | O=C1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CCN1CCc1ccccc1 | 10.1021/jm980569z | |||
| CHEMBL161970 | 55437 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 428 | 8 | 1 | 5 | 3.1 | O=C1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CCN1CCc1ccccc1 | 10.1021/jm980569z | |||
| 11795525 | 121116 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 404 | 8 | 2 | 6 | 3.5 | c1cc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)co1 | 10.1021/jm9910021 | |||
| CHEMBL357408 | 121116 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 404 | 8 | 2 | 6 | 3.5 | c1cc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)co1 | 10.1021/jm9910021 | |||
| 10766321 | 40142 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 458 | 10 | 3 | 6 | 3.7 | OC[C@H](NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL147979 | 40142 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 458 | 10 | 3 | 6 | 3.7 | OC[C@H](NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| 6604720 | 15273 | 3 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 386 | 7 | 1 | 5 | 2.9 | O=C1CC2(CCCC2)CC(=O)N1CCCCNC[C@H]1COc2ccccc2O1 | 10.1021/jm00401a007 | |||
| CHEMBL12129 | 15273 | 3 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 386 | 7 | 1 | 5 | 2.9 | O=C1CC2(CCCC2)CC(=O)N1CCCCNC[C@H]1COc2ccccc2O1 | 10.1021/jm00401a007 | |||
| 10621021 | 203384 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 400 | 7 | 1 | 5 | 3.5 | c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9704560 | |||
| CHEMBL65367 | 203384 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 400 | 7 | 1 | 5 | 3.5 | c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9704560 | |||
| 134551 | 358 | 27 | None | -5 | 21 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 575 | 5 | 3 | 6 | 2.4 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C | nan | |||
| 271 | 358 | 27 | None | -5 | 21 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 575 | 5 | 3 | 6 | 2.4 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C | nan | |||
| 885 | 358 | 27 | None | -5 | 21 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 575 | 5 | 3 | 6 | 2.4 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C | nan | |||
| CHEMBL1403281 | 358 | 27 | None | -5 | 21 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 575 | 5 | 3 | 6 | 2.4 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C | nan | |||
| 10505525 | 38382 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 499 | 10 | 3 | 6 | 4.7 | CC(=O)Nc1ccc([C@@H](C)NCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
| CHEMBL146338 | 38382 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 499 | 10 | 3 | 6 | 4.7 | CC(=O)Nc1ccc([C@@H](C)NCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
| 10767244 | 40089 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 485 | 10 | 3 | 6 | 4.1 | CC(=O)Nc1ccc(CNCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
| CHEMBL147940 | 40089 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 485 | 10 | 3 | 6 | 4.1 | CC(=O)Nc1ccc(CNCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
| 10096048 | 98855 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 465 | 4 | 2 | 4 | 4.5 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4cc(F)ccc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
| CHEMBL278917 | 98855 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 465 | 4 | 2 | 4 | 4.5 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4cc(F)ccc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
| 9804849 | 67456 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 472 | 8 | 1 | 5 | 5.1 | Cc1cc(N(C)CCN(C)C)nc2ccc(NC(=O)/C=C/c3ccc(OC(F)(F)F)cc3)cc12 | 10.1021/jm050103y | |||
| CHEMBL189118 | 67456 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 472 | 8 | 1 | 5 | 5.1 | Cc1cc(N(C)CCN(C)C)nc2ccc(NC(=O)/C=C/c3ccc(OC(F)(F)F)cc3)cc12 | 10.1021/jm050103y | |||
| 9981024 | 96097 | 0 | None | - | 1 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 446 | 11 | 1 | 5 | 3.8 | CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL26018 | 96097 | 0 | None | - | 1 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 446 | 11 | 1 | 5 | 3.8 | CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL300735 | 96097 | 0 | None | - | 1 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 446 | 11 | 1 | 5 | 3.8 | CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| 10786628 | 38455 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 390 | 7 | 1 | 5 | 3.1 | CC#CCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| CHEMBL146396 | 38455 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 390 | 7 | 1 | 5 | 3.1 | CC#CCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| 14450364 | 56003 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 247 | 1 | 0 | 3 | 2.6 | COc1cc(C)cc2c1[C@H]1CCCN(C)[C@@H]1CO2 | 10.1021/jm00123a039 | |||
| CHEMBL162449 | 56003 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 247 | 1 | 0 | 3 | 2.6 | COc1cc(C)cc2c1[C@H]1CCCN(C)[C@@H]1CO2 | 10.1021/jm00123a039 | |||
| 11626724 | 110476 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 458 | 9 | 3 | 6 | 3.6 | Cc1ccccc1CNCC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
| CHEMBL324751 | 110476 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 458 | 9 | 3 | 6 | 3.6 | Cc1ccccc1CNCC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
| 6426761 | 13957 | 1 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 450 | 8 | 1 | 5 | 3.8 | Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1F | 10.1021/jm980569z | |||
| CHEMBL119668 | 13957 | 1 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 450 | 8 | 1 | 5 | 3.8 | Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1F | 10.1021/jm980569z | |||
| 9881324 | 28372 | 3 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 244 | 3 | 1 | 2 | 2.8 | COc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1 | 10.1021/jm00101a032 | |||
| CHEMBL137485 | 28372 | 3 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 244 | 3 | 1 | 2 | 2.8 | COc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1 | 10.1021/jm00101a032 | |||
| 10709057 | 120068 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 296 | 3 | 1 | 4 | 3.3 | Cc1noc(-c2ccc3[nH]cc([C@H]4C[C@H](N(C)C)C4)c3c2)n1 | 10.1021/jm000956k | |||
| CHEMBL350637 | 120068 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 296 | 3 | 1 | 4 | 3.3 | Cc1noc(-c2ccc3[nH]cc([C@H]4C[C@H](N(C)C)C4)c3c2)n1 | 10.1021/jm000956k | |||
| 44341798 | 9816 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 424 | 8 | 3 | 6 | 3.1 | CC(C)(C)CNCC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
| CHEMBL113831 | 9816 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 424 | 8 | 3 | 6 | 3.1 | CC(C)(C)CNCC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
| 11798621 | 40299 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 471 | 9 | 3 | 6 | 3.8 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)C(=O)Nc1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL148110 | 40299 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 471 | 9 | 3 | 6 | 3.8 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)C(=O)Nc1ccccc1 | 10.1021/jm9910021 | |||
| 10412189 | 77253 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 465 | 4 | 2 | 4 | 4.5 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(F)cc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
| CHEMBL2079627 | 77253 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 465 | 4 | 2 | 4 | 4.5 | COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(F)cc34)CC2)cc1N1CCN(C)CC1 | 10.1021/jm9811054 | |||
| 10670211 | 120220 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 428 | 9 | 1 | 5 | 3.9 | c1ccc(CCCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
| CHEMBL352123 | 120220 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 428 | 9 | 1 | 5 | 3.9 | c1ccc(CCCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm980569z | |||
| 10739818 | 111143 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 401 | 8 | 1 | 5 | 3.8 | c1ccc(COC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
| CHEMBL326371 | 111143 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 401 | 8 | 1 | 5 | 3.8 | c1ccc(COC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
| 10719245 | 37808 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 472 | 10 | 2 | 6 | 4.1 | CN(CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@@H](CO)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL145849 | 37808 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 472 | 10 | 2 | 6 | 4.1 | CN(CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@@H](CO)c1ccccc1 | 10.1021/jm9910021 | |||
| 176 | 398 | 66 | None | -10 | 31 | Rat | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
| 2157 | 398 | 66 | None | -10 | 31 | Rat | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
| 2566 | 398 | 66 | None | -10 | 31 | Rat | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
| CHEMBL633 | 398 | 66 | None | -10 | 31 | Rat | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
| DB01118 | 398 | 66 | None | -10 | 31 | Rat | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
| 2105 | 3054 | 37 | None | -27 | 33 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | nan | |||
| 47811 | 3054 | 37 | None | -27 | 33 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | nan | |||
| 48 | 3054 | 37 | None | -27 | 33 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | nan | |||
| CHEMBL531 | 3054 | 37 | None | -27 | 33 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | nan | |||
| DB01186 | 3054 | 37 | None | -27 | 33 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | nan | |||
| 10500370 | 52790 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 386 | 7 | 2 | 5 | 3.7 | c1ccc(NC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
| CHEMBL159493 | 52790 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 386 | 7 | 2 | 5 | 3.7 | c1ccc(NC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9805687 | |||
| 10670879 | 119868 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 442 | 9 | 1 | 5 | 4.4 | C[C@@H](c1ccccc1)N(C)C[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1 | 10.1021/jm9805687 | |||
| CHEMBL348864 | 119868 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 442 | 9 | 1 | 5 | 4.4 | C[C@@H](c1ccccc1)N(C)C[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1 | 10.1021/jm9805687 | |||
| 10739818 | 111143 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 401 | 8 | 1 | 5 | 3.8 | c1ccc(COC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9704558 | |||
| CHEMBL326371 | 111143 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 401 | 8 | 1 | 5 | 3.8 | c1ccc(COC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1 | 10.1021/jm9704558 | |||
| 44341609 | 9895 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 472 | 9 | 2 | 6 | 3.9 | Cc1ccccc1CN(C)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
| CHEMBL114303 | 9895 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 472 | 9 | 2 | 6 | 3.9 | Cc1ccccc1CN(C)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
| 10600678 | 119197 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 476 | 10 | 2 | 6 | 4.3 | COC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1 | 10.1021/jm9910021 | |||
| CHEMBL343217 | 119197 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 476 | 10 | 2 | 6 | 4.3 | COC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1 | 10.1021/jm9910021 | |||
| 10811964 | 168334 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 418 | 8 | 1 | 6 | 3.9 | CN(Cc1ccco1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| CHEMBL434315 | 168334 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 418 | 8 | 1 | 6 | 3.9 | CN(Cc1ccco1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm9910021 | |||
| 3245407 | 48105 | 25 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 212 | 1 | 2 | 1 | 2.9 | Cc1[nH]c2ccccc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
| CHEMBL1550957 | 48105 | 25 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 212 | 1 | 2 | 1 | 2.9 | Cc1[nH]c2ccccc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
| 441383 | 20333 | 57 | None | -19 | 16 | Rat | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 531 | 8 | 0 | 8 | 4.5 | CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | nan | |||
| CHEMBL1306 | 20333 | 57 | None | -19 | 16 | Rat | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 531 | 8 | 0 | 8 | 4.5 | CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | nan | |||
| 10720175 | 38570 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 499 | 10 | 3 | 6 | 4.7 | CC(=O)Nc1ccc([C@H](C)NCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
| CHEMBL146483 | 38570 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 499 | 10 | 3 | 6 | 4.7 | CC(=O)Nc1ccc([C@H](C)NCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | 10.1021/jm9910021 | |||
| 10788768 | 56495 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 430 | 8 | 2 | 6 | 3.0 | OCC(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
| CHEMBL163386 | 56495 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 430 | 8 | 2 | 6 | 3.0 | OCC(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
| 10588665 | 89269 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 278 | 3 | 2 | 2 | 4.2 | N[C@H]1C[C@H](c2c[nH]c3ccc(Oc4ccccc4)cc32)C1 | 10.1021/jm000956k | |||
| CHEMBL2368254 | 89269 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 278 | 3 | 2 | 2 | 4.2 | N[C@H]1C[C@H](c2c[nH]c3ccc(Oc4ccccc4)cc32)C1 | 10.1021/jm000956k | |||
| 9981024 | 96097 | 0 | None | - | 1 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 446 | 11 | 1 | 5 | 3.8 | CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL26018 | 96097 | 0 | None | - | 1 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 446 | 11 | 1 | 5 | 3.8 | CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| CHEMBL300735 | 96097 | 0 | None | - | 1 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 446 | 11 | 1 | 5 | 3.8 | CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1 | 10.1021/jm00038a007 | |||
| 10247171 | 203427 | 0 | None | - | 0 | Rat | 4.0 | pIC50 | = | 4.0 | Binding | ChEMBL | 348 | 3 | 0 | 5 | 3.9 | c1ccc(CN2CCN(c3nc4sccc4n4cccc34)CC2)cc1 | 10.1021/jm950543x | |||
| CHEMBL65710 | 203427 | 0 | None | - | 0 | Rat | 4.0 | pIC50 | = | 4.0 | Binding | ChEMBL | 348 | 3 | 0 | 5 | 3.9 | c1ccc(CN2CCN(c3nc4sccc4n4cccc34)CC2)cc1 | 10.1021/jm950543x | |||
| 10811801 | 120144 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 415 | 8 | 1 | 6 | 2.9 | c1cncc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm980569z | |||
| CHEMBL351311 | 120144 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 415 | 8 | 1 | 6 | 2.9 | c1cncc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | 10.1021/jm980569z | |||
| 10519108 | 52944 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 311 | 5 | 2 | 5 | 1.6 | OC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9805687 | |||
| CHEMBL159627 | 52944 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 311 | 5 | 2 | 5 | 1.6 | OC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9805687 | |||
| 10780344 | 119936 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 297 | 4 | 2 | 5 | 1.4 | O[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9805687 | |||
| CHEMBL349528 | 119936 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 297 | 4 | 2 | 5 | 1.4 | O[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | 10.1021/jm9805687 | |||
| 10526737 | 102742 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 432 | 8 | 1 | 5 | 3.5 | FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCN(CCc2ccccc2)CC1 | 10.1021/jm981133m | |||
| CHEMBL304993 | 102742 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 432 | 8 | 1 | 5 | 3.5 | FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCN(CCc2ccccc2)CC1 | 10.1021/jm981133m | |||
| 10526567 | 40268 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 428 | 8 | 2 | 5 | 4.5 | C[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL148087 | 40268 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 428 | 8 | 2 | 5 | 4.5 | C[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| 10456869 | 9992 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 458 | 9 | 2 | 6 | 3.6 | CN(Cc1ccccc1)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
| CHEMBL114877 | 9992 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 458 | 9 | 2 | 6 | 3.6 | CN(Cc1ccccc1)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1016/s0960-894x(99)00614-9 | |||
| 10494885 | 89268 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 306 | 4 | 1 | 2 | 4.8 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(Oc4ccccc4)cc32)C1 | 10.1021/jm000956k | |||
| CHEMBL2368253 | 89268 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 306 | 4 | 1 | 2 | 4.8 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(Oc4ccccc4)cc32)C1 | 10.1021/jm000956k | |||
| 18691565 | 89272 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 327 | 4 | 1 | 3 | 3.0 | CN1C(=O)OCC1Cc1ccc2[nH]cc([C@H]3C[C@H](N(C)C)C3)c2c1 | 10.1021/jm000956k | |||
| CHEMBL2368257 | 89272 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 327 | 4 | 1 | 3 | 3.0 | CN1C(=O)OCC1Cc1ccc2[nH]cc([C@H]3C[C@H](N(C)C)C3)c2c1 | 10.1021/jm000956k | |||
| 10834414 | 188894 | 0 | None | - | 0 | Rat | 4.0 | pIC50 | = | 4.0 | Binding | ChEMBL | 393 | 3 | 0 | 5 | 4.4 | c1ccc(CN2CCN(c3nc4ccc5ncccc5c4n4cccc34)CC2)cc1 | 10.1021/jm960501o | |||
| CHEMBL50740 | 188894 | 0 | None | - | 0 | Rat | 4.0 | pIC50 | = | 4.0 | Binding | ChEMBL | 393 | 3 | 0 | 5 | 4.4 | c1ccc(CN2CCN(c3nc4ccc5ncccc5c4n4cccc34)CC2)cc1 | 10.1021/jm960501o | |||
| 10504097 | 40393 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 458 | 9 | 3 | 6 | 3.6 | CC(CO)(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| CHEMBL148194 | 40393 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 458 | 9 | 3 | 6 | 3.6 | CC(CO)(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | 10.1021/jm9910021 | |||
| 9802530 | 35386 | 1 | None | -2 | 4 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 336 | 5 | 1 | 4 | 2.5 | CN(C)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
| CHEMBL143767 | 35386 | 1 | None | -2 | 4 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 336 | 5 | 1 | 4 | 2.5 | CN(C)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
| 10526736 | 10222 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1ccccc1CCN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
| CHEMBL116031 | 10222 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1ccccc1CCN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | 10.1021/jm980569z | |||
| 6426761 | 13957 | 1 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 450 | 8 | 1 | 5 | 3.8 | Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1F | 10.1021/jm9704560 | |||
| CHEMBL119668 | 13957 | 1 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 450 | 8 | 1 | 5 | 3.8 | Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1F | 10.1021/jm9704560 | |||
| 23533297 | 193025 | 2 | None | - | 1 | Guinea pig | 9.4 | pKd | = | 9.4 | Binding | ChEMBL | 462 | 4 | 1 | 7 | 2.9 | Cc1ccc(N2CCN(C)CC2)c2oc(C(=O)Nc3ccc(N4CCOCC4)cc3)cc(=O)c12 | 10.1021/acs.jmedchem.2c00633 | |||
| CHEMBL5209320 | 193025 | 2 | None | - | 1 | Guinea pig | 9.4 | pKd | = | 9.4 | Binding | ChEMBL | 462 | 4 | 1 | 7 | 2.9 | Cc1ccc(N2CCN(C)CC2)c2oc(C(=O)Nc3ccc(N4CCOCC4)cc3)cc(=O)c12 | 10.1021/acs.jmedchem.2c00633 | |||
| CHEMBL5222828 | 193025 | 2 | None | - | 1 | Guinea pig | 9.4 | pKd | = | 9.4 | Binding | ChEMBL | 462 | 4 | 1 | 7 | 2.9 | Cc1ccc(N2CCN(C)CC2)c2oc(C(=O)Nc3ccc(N4CCOCC4)cc3)cc(=O)c12 | 10.1021/acs.jmedchem.2c00633 | |||
| 2869 | 4152 | 89 | None | -8 | 7 | Human | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1021/jm00018a016 | |||
| 60 | 4152 | 89 | None | -8 | 7 | Human | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1021/jm00018a016 | |||
| 60857 | 4152 | 89 | None | -8 | 7 | Human | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1021/jm00018a016 | |||
| CHEMBL1185 | 4152 | 89 | None | -8 | 7 | Human | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1021/jm00018a016 | |||
| DB00315 | 4152 | 89 | None | -8 | 7 | Human | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1021/jm00018a016 | |||
| 23533297 | 193025 | 2 | None | - | 1 | Guinea pig | 11.0 | pKi | = | 11 | Binding | ChEMBL | 462 | 4 | 1 | 7 | 2.9 | Cc1ccc(N2CCN(C)CC2)c2oc(C(=O)Nc3ccc(N4CCOCC4)cc3)cc(=O)c12 | 10.1021/acs.jmedchem.2c00633 | |||
| CHEMBL5209320 | 193025 | 2 | None | - | 1 | Guinea pig | 11.0 | pKi | = | 11 | Binding | ChEMBL | 462 | 4 | 1 | 7 | 2.9 | Cc1ccc(N2CCN(C)CC2)c2oc(C(=O)Nc3ccc(N4CCOCC4)cc3)cc(=O)c12 | 10.1021/acs.jmedchem.2c00633 | |||
| CHEMBL5222828 | 193025 | 2 | None | - | 1 | Guinea pig | 11.0 | pKi | = | 11 | Binding | ChEMBL | 462 | 4 | 1 | 7 | 2.9 | Cc1ccc(N2CCN(C)CC2)c2oc(C(=O)Nc3ccc(N4CCOCC4)cc3)cc(=O)c12 | 10.1021/acs.jmedchem.2c00633 | |||
| 1043 | 1582 | 14 | None | 4 | 28 | Rat | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
| 149 | 1582 | 14 | None | 4 | 28 | Rat | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
| 8223 | 1582 | 14 | None | 4 | 28 | Rat | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
| CHEMBL442 | 1582 | 14 | None | 4 | 28 | Rat | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
| DB00696 | 1582 | 14 | None | 4 | 28 | Rat | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
| 11797998 | 35692 | 0 | None | 1 | 3 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3ccc(COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12 | 10.1021/jm7011722 | |||
| CHEMBL144030 | 35692 | 0 | None | 1 | 3 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3ccc(COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12 | 10.1021/jm7011722 | |||
| 24881753 | 137202 | 0 | None | 14 | 2 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 666 | 16 | 4 | 4 | 9.1 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
| CHEMBL374973 | 137202 | 0 | None | 14 | 2 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 666 | 16 | 4 | 4 | 9.1 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
| 107780 | 1844 | 54 | None | 1 | 17 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1016/S0960-894X(97)10164-0 | |||
| 14 | 1844 | 54 | None | 1 | 17 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL15928 | 1844 | 54 | None | 1 | 17 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1016/S0960-894X(97)10164-0 | |||
| 107780 | 1844 | 54 | None | 1 | 17 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1016/j.bmcl.2005.07.024 | |||
| 14 | 1844 | 54 | None | 1 | 17 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1016/j.bmcl.2005.07.024 | |||
| CHEMBL15928 | 1844 | 54 | None | 1 | 17 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1016/j.bmcl.2005.07.024 | |||
| 44351656 | 117098 | 0 | None | 5 | 3 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 499 | 6 | 2 | 7 | 4.3 | COc1ccc(NC(=O)c2ccc(-c3ccc(C4=NC(C)ON4)cc3C)cc2)cc1N1CCN(C)CC1 | 10.1021/jm9703552 | |||
| CHEMBL339308 | 117098 | 0 | None | 5 | 3 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 499 | 6 | 2 | 7 | 4.3 | COc1ccc(NC(=O)c2ccc(-c3ccc(C4=NC(C)ON4)cc3C)cc2)cc1N1CCN(C)CC1 | 10.1021/jm9703552 | |||
| 44443130 | 93769 | 0 | None | 1 | 3 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 464 | 6 | 0 | 6 | 3.2 | Cc1ccc2c(OCCN3CCN(Cc4cc(F)c5c(c4)N(C)C(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2007.06.078 | |||
| CHEMBL247428 | 93769 | 0 | None | 1 | 3 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 464 | 6 | 0 | 6 | 3.2 | Cc1ccc2c(OCCN3CCN(Cc4cc(F)c5c(c4)N(C)C(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2007.06.078 | |||
| 9909089 | 186968 | 0 | None | -23 | 7 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
| CHEMBL490417 | 186968 | 0 | None | -23 | 7 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
| 6160690 | 119321 | 37 | None | 6 | 3 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 377 | 8 | 2 | 3 | 3.6 | COc1ccc(CNC(=O)/C=C/c2ccc3[nH]cc(CCN(C)C)c3c2)cc1 | 10.1021/jm9604890 | |||
| CHEMBL344127 | 119321 | 37 | None | 6 | 3 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 377 | 8 | 2 | 3 | 3.6 | COc1ccc(CNC(=O)/C=C/c2ccc3[nH]cc(CCN(C)C)c3c2)cc1 | 10.1021/jm9604890 | |||
| 71461632 | 78778 | 0 | None | 2 | 3 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 472 | 6 | 0 | 5 | 3.6 | Cc1ccccc1CN1CCN(C(=O)COc2ccc3cccc(N4CCN(C)CC4)c3c2)CC1 | 10.1021/jm9703552 | |||
| CHEMBL2112662 | 78778 | 0 | None | 2 | 3 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 472 | 6 | 0 | 5 | 3.6 | Cc1ccccc1CN1CCN(C(=O)COc2ccc3cccc(N4CCN(C)CC4)c3c2)CC1 | 10.1021/jm9703552 | |||
| 44404240 | 72527 | 0 | None | 1 | 3 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 441 | 2 | 0 | 5 | 3.6 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccc(C(F)(F)F)nc2)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
| CHEMBL199088 | 72527 | 0 | None | 1 | 3 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 441 | 2 | 0 | 5 | 3.6 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccc(C(F)(F)F)nc2)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
| 59636728 | 125684 | 0 | None | - | 1 | Chinese hamster | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 544 | 7 | 1 | 7 | 4.6 | O=C(NC1CCN(c2ncccc2Cl)CC1)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| CHEMBL3647266 | 125684 | 0 | None | - | 1 | Chinese hamster | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 544 | 7 | 1 | 7 | 4.6 | O=C(NC1CCN(c2ncccc2Cl)CC1)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| 124 | 2981 | 47 | None | 1 | 33 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | 10.1021/jm970513p | |||
| 2032 | 2981 | 47 | None | 1 | 33 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | 10.1021/jm970513p | |||
| 4636 | 2981 | 47 | None | 1 | 33 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | 10.1021/jm970513p | |||
| CHEMBL762 | 2981 | 47 | None | 1 | 33 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | 10.1021/jm970513p | |||
| DB00935 | 2981 | 47 | None | 1 | 33 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | 10.1021/jm970513p | |||
| 9955819 | 118144 | 0 | None | 2 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 458 | 5 | 0 | 5 | 3.6 | Cc1ccccc1N1CCN(C(=O)COc2ccc3cccc(N4CCN(C)CC4)c3c2)CC1 | 10.1021/jm9703552 | |||
| CHEMBL340786 | 118144 | 0 | None | 2 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 458 | 5 | 0 | 5 | 3.6 | Cc1ccccc1N1CCN(C(=O)COc2ccc3cccc(N4CCN(C)CC4)c3c2)CC1 | 10.1021/jm9703552 | |||
| 188 | 3391 | 80 | None | 1 | 6 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 281 | 2 | 1 | 3 | 4.1 | Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C | 10.1016/j.bmcl.2015.07.012 | |||
| 196968 | 3391 | 80 | None | 1 | 6 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 281 | 2 | 1 | 3 | 4.1 | Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C | 10.1016/j.bmcl.2015.07.012 | |||
| CHEMBL473186 | 3391 | 80 | None | 1 | 6 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 281 | 2 | 1 | 3 | 4.1 | Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C | 10.1016/j.bmcl.2015.07.012 | |||
| 10073139 | 184296 | 0 | None | 1 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 464 | 5 | 1 | 5 | 4.6 | O=C1COc2ccc(CCN3CCN(c4cccc5nc(-c6ccccc6)ccc45)CC3)cc2N1 | 10.1016/j.bmcl.2008.08.084 | |||
| CHEMBL484059 | 184296 | 0 | None | 1 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 464 | 5 | 1 | 5 | 4.6 | O=C1COc2ccc(CCN3CCN(c4cccc5nc(-c6ccccc6)ccc45)CC3)cc2N1 | 10.1016/j.bmcl.2008.08.084 | |||
| 44404225 | 133533 | 0 | None | 1 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 406 | 2 | 0 | 4 | 3.8 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccc(Cl)cc2)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
| CHEMBL370852 | 133533 | 0 | None | 1 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 406 | 2 | 0 | 4 | 3.8 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccc(Cl)cc2)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
| 10838063 | 78776 | 0 | None | 1 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 469 | 5 | 0 | 6 | 3.2 | CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(c5ccccc5C#N)CC4)cc23)CC1 | 10.1021/jm9703552 | |||
| CHEMBL2112660 | 78776 | 0 | None | 1 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 469 | 5 | 0 | 6 | 3.2 | CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(c5ccccc5C#N)CC4)cc23)CC1 | 10.1021/jm9703552 | |||
| 10531 | 1420 | 21 | None | -5 | 23 | Rat | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
| 121 | 1420 | 21 | None | -5 | 23 | Rat | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
| 888 | 1420 | 21 | None | -5 | 23 | Rat | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
| CHEMBL1732 | 1420 | 21 | None | -5 | 23 | Rat | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
| DB00320 | 1420 | 21 | None | -5 | 23 | Rat | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | |||
| 9977716 | 170130 | 0 | None | -1 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 390 | 4 | 2 | 4 | 3.2 | Cc1cc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2008.08.084 | |||
| CHEMBL444398 | 170130 | 0 | None | -1 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 390 | 4 | 2 | 4 | 3.2 | Cc1cc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2008.08.084 | |||
| 10454806 | 187885 | 0 | None | -1 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 420 | 4 | 1 | 5 | 3.4 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4F)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
| CHEMBL496520 | 187885 | 0 | None | -1 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 420 | 4 | 1 | 5 | 3.4 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4F)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
| 45104767 | 201610 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 506 | 5 | 1 | 8 | 4.2 | COC1(c2ccc(NC(=O)c3cc(=O)c4cc(F)cc(-c5c(C)nn(C)c5C)c4o3)cn2)CCOCC1 | 10.1021/jm901200t | |||
| CHEMBL605785 | 201610 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 506 | 5 | 1 | 8 | 4.2 | COC1(c2ccc(NC(=O)c3cc(=O)c4cc(F)cc(-c5c(C)nn(C)c5C)c4o3)cn2)CCOCC1 | 10.1021/jm901200t | |||
| 45104767 | 201610 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 506 | 5 | 1 | 8 | 4.2 | COC1(c2ccc(NC(=O)c3cc(=O)c4cc(F)cc(-c5c(C)nn(C)c5C)c4o3)cn2)CCOCC1 | 10.1021/jm901200t | |||
| CHEMBL605785 | 201610 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 506 | 5 | 1 | 8 | 4.2 | COC1(c2ccc(NC(=O)c3cc(=O)c4cc(F)cc(-c5c(C)nn(C)c5C)c4o3)cn2)CCOCC1 | 10.1021/jm901200t | |||
| 10649124 | 19470 | 0 | None | 1 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 502 | 5 | 0 | 7 | 3.1 | CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(c5cccc6c5OCCO6)CC4)cc23)CC1 | 10.1021/jm9703552 | |||
| CHEMBL129813 | 19470 | 0 | None | 1 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 502 | 5 | 0 | 7 | 3.1 | CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(c5cccc6c5OCCO6)CC4)cc23)CC1 | 10.1021/jm9703552 | |||
| 10672840 | 78777 | 0 | None | 2 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 494 | 5 | 0 | 5 | 4.5 | CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(c5cccc6ccccc56)CC4)cc23)CC1 | 10.1021/jm9703552 | |||
| CHEMBL2112661 | 78777 | 0 | None | 2 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 494 | 5 | 0 | 5 | 4.5 | CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(c5cccc6ccccc56)CC4)cc23)CC1 | 10.1021/jm9703552 | |||
| 10601619 | 116836 | 0 | None | 1 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 504 | 7 | 0 | 7 | 3.3 | COc1cccc(N2CCN(C(=O)COc3ccc4cccc(N5CCN(C)CC5)c4c3)CC2)c1OC | 10.1021/jm9703552 | |||
| CHEMBL338015 | 116836 | 0 | None | 1 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 504 | 7 | 0 | 7 | 3.3 | COc1cccc(N2CCN(C(=O)COc3ccc4cccc(N5CCN(C)CC5)c4c3)CC2)c1OC | 10.1021/jm9703552 | |||
| 59636724 | 126208 | 0 | None | - | 1 | Chinese hamster | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 483 | 7 | 0 | 7 | 3.5 | O=C(c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1)N1CC(Oc2cccnc2)C1 | nan | |||
| CHEMBL3650029 | 126208 | 0 | None | - | 1 | Chinese hamster | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 483 | 7 | 0 | 7 | 3.5 | O=C(c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1)N1CC(Oc2cccnc2)C1 | nan | |||
| 10434550 | 12099 | 0 | None | 52 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 463 | 4 | 1 | 5 | 3.7 | COc1ccc(NC(=O)N2CCN(c3cccc4c3CCCC4)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL1183948 | 12099 | 0 | None | 52 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 463 | 4 | 1 | 5 | 3.7 | COc1ccc(NC(=O)N2CCN(c3cccc4c3CCCC4)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL325359 | 12099 | 0 | None | 52 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 463 | 4 | 1 | 5 | 3.7 | COc1ccc(NC(=O)N2CCN(c3cccc4c3CCCC4)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| 24881204 | 188422 | 0 | None | 3 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 680 | 17 | 4 | 4 | 9.5 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
| CHEMBL502138 | 188422 | 0 | None | 3 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 680 | 17 | 4 | 4 | 9.5 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
| 10673329 | 99332 | 0 | None | 10 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 512 | 8 | 0 | 7 | 5.2 | COc1cc2c(cc1OCCN(C)C)N(C(=O)c1ccc(-c3ccc(-c4noc(C)n4)cc3C)cc1)CC2 | 10.1021/jm970457s | |||
| CHEMBL282229 | 99332 | 0 | None | 10 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 512 | 8 | 0 | 7 | 5.2 | COc1cc2c(cc1OCCN(C)C)N(C(=O)c1ccc(-c3ccc(-c4noc(C)n4)cc3C)cc1)CC2 | 10.1021/jm970457s | |||
| 49850672 | 56386 | 0 | None | -1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 404 | 5 | 1 | 5 | 4.1 | COC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
| CHEMBL1631532 | 56386 | 0 | None | -1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 404 | 5 | 1 | 5 | 4.1 | COC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
| 49850872 | 56458 | 0 | None | -1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 388 | 5 | 1 | 4 | 3.9 | CC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
| CHEMBL1632206 | 56458 | 0 | None | -1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 388 | 5 | 1 | 4 | 3.9 | CC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
| 9909089 | 186968 | 0 | None | -23 | 7 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1021/jm100714c | |||
| CHEMBL490417 | 186968 | 0 | None | -23 | 7 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1021/jm100714c | |||
| 10478217 | 188087 | 0 | None | -2 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 436 | 4 | 1 | 5 | 3.9 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)ccc(Cl)c2n1 | 10.1016/j.bmcl.2008.08.084 | |||
| CHEMBL497980 | 188087 | 0 | None | -2 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 436 | 4 | 1 | 5 | 3.9 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)ccc(Cl)c2n1 | 10.1016/j.bmcl.2008.08.084 | |||
| 10071738 | 192599 | 0 | None | -3 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 436 | 4 | 1 | 5 | 3.9 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
| CHEMBL521506 | 192599 | 0 | None | -3 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 436 | 4 | 1 | 5 | 3.9 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
| 9979309 | 192982 | 0 | None | -5 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 416 | 4 | 0 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
| CHEMBL522257 | 192982 | 0 | None | -5 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 416 | 4 | 0 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
| 9909089 | 186968 | 0 | None | -23 | 7 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.110 | |||
| CHEMBL490417 | 186968 | 0 | None | -23 | 7 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 402 | 4 | 1 | 5 | 3.2 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.110 | |||
| 44404229 | 70486 | 0 | None | 1 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 397 | 2 | 0 | 5 | 3.1 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccc(C#N)cc2)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
| CHEMBL194647 | 70486 | 0 | None | 1 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 397 | 2 | 0 | 5 | 3.1 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccc(C#N)cc2)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
| 59636723 | 125679 | 0 | None | - | 1 | Chinese hamster | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 509 | 7 | 1 | 6 | 4.6 | O=C(NC1CCN(c2ccccc2)CC1)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| CHEMBL3647261 | 125679 | 0 | None | - | 1 | Chinese hamster | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 509 | 7 | 1 | 6 | 4.6 | O=C(NC1CCN(c2ccccc2)CC1)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| 59636782 | 125700 | 0 | None | - | 1 | Chinese hamster | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 540 | 8 | 1 | 8 | 4.0 | COc1cccnc1N1CCC(NC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)CC1 | nan | |||
| CHEMBL3647282 | 125700 | 0 | None | - | 1 | Chinese hamster | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 540 | 8 | 1 | 8 | 4.0 | COc1cccnc1N1CCC(NC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)CC1 | nan | |||
| 24881754 | 188292 | 0 | None | 3 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 694 | 18 | 4 | 4 | 9.9 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
| CHEMBL500284 | 188292 | 0 | None | 3 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 694 | 18 | 4 | 4 | 9.9 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
| 44402885 | 71814 | 0 | None | 25 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 469 | 4 | 0 | 4 | 5.4 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)c1ccc(-c3ccccc3C)cc1)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| CHEMBL196848 | 71814 | 0 | None | 25 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 469 | 4 | 0 | 4 | 5.4 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)c1ccc(-c3ccccc3C)cc1)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| 10001971 | 184324 | 0 | None | -5 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 416 | 4 | 1 | 5 | 3.5 | Cc1cc(N2CCN(CCc3ccc4c(c3)NC(=O)CO4)CC2)c2ccc(C)nc2c1 | 10.1016/j.bmcl.2008.08.084 | |||
| CHEMBL484260 | 184324 | 0 | None | -5 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 416 | 4 | 1 | 5 | 3.5 | Cc1cc(N2CCN(CCc3ccc4c(c3)NC(=O)CO4)CC2)c2ccc(C)nc2c1 | 10.1016/j.bmcl.2008.08.084 | |||
| 10341129 | 186798 | 0 | None | -1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 403 | 4 | 1 | 6 | 2.6 | Cc1ncc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
| CHEMBL489195 | 186798 | 0 | None | -1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 403 | 4 | 1 | 6 | 2.6 | Cc1ncc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
| 10319235 | 187137 | 0 | None | -3 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 407 | 4 | 1 | 5 | 3.1 | CC1(C)Cc2cccc(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)c2O1 | 10.1016/j.bmcl.2008.08.084 | |||
| CHEMBL491839 | 187137 | 0 | None | -3 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 407 | 4 | 1 | 5 | 3.1 | CC1(C)Cc2cccc(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)c2O1 | 10.1016/j.bmcl.2008.08.084 | |||
| 9955522 | 72489 | 0 | None | -1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 452 | 3 | 0 | 6 | 3.7 | Cc1c(C(=O)N2CCc3cc4ccnc(N5CCN(C)CC5)c4cc32)cnn1-c1ccccc1 | 10.1016/j.bmcl.2005.06.042 | |||
| CHEMBL198975 | 72489 | 0 | None | -1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 452 | 3 | 0 | 6 | 3.7 | Cc1c(C(=O)N2CCc3cc4ccnc(N5CCN(C)CC5)c4cc32)cnn1-c1ccccc1 | 10.1016/j.bmcl.2005.06.042 | |||
| 9832057 | 52315 | 0 | None | 1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 692 | 16 | 2 | 6 | 4.8 | CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N(C)Cc3ccc(CN(C)S(=O)(=O)Cc4ccc5[nH]cc(CCN(C)C)c5c4)cc3)cc12 | 10.1021/jm7011722 | |||
| CHEMBL158941 | 52315 | 0 | None | 1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 692 | 16 | 2 | 6 | 4.8 | CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N(C)Cc3ccc(CN(C)S(=O)(=O)Cc4ccc5[nH]cc(CCN(C)C)c5c4)cc3)cc12 | 10.1021/jm7011722 | |||
| 9832057 | 52315 | 0 | None | 1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 692 | 16 | 2 | 6 | 4.8 | CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N(C)Cc3ccc(CN(C)S(=O)(=O)Cc4ccc5[nH]cc(CCN(C)C)c5c4)cc3)cc12 | 10.1016/s0960-894x(98)00090-0 | |||
| CHEMBL158941 | 52315 | 0 | None | 1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 692 | 16 | 2 | 6 | 4.8 | CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N(C)Cc3ccc(CN(C)S(=O)(=O)Cc4ccc5[nH]cc(CCN(C)C)c5c4)cc3)cc12 | 10.1016/s0960-894x(98)00090-0 | |||
| 44279549 | 99440 | 0 | None | -1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 606 | 11 | 4 | 7 | 4.6 | CN1CCN(c2cccc3ccc(OCC(=O)Nc4ccc(NC(=O)COc5ccc6[nH]cc(CCN)c6c5)cc4)cc23)CC1 | 10.1016/s0960-894x(98)00222-4 | |||
| CHEMBL282950 | 99440 | 0 | None | -1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 606 | 11 | 4 | 7 | 4.6 | CN1CCN(c2cccc3ccc(OCC(=O)Nc4ccc(NC(=O)COc5ccc6[nH]cc(CCN)c6c5)cc4)cc23)CC1 | 10.1016/s0960-894x(98)00222-4 | |||
| 59636764 | 125694 | 0 | None | - | 1 | Chinese hamster | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 484 | 9 | 1 | 6 | 4.2 | COc1cccc(CCNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)c1 | nan | |||
| CHEMBL3647276 | 125694 | 0 | None | - | 1 | Chinese hamster | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 484 | 9 | 1 | 6 | 4.2 | COc1cccc(CCNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)c1 | nan | |||
| 44279525 | 105512 | 0 | None | -1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 444 | 8 | 2 | 5 | 4.0 | CN1CCN(c2cccc3ccc(OCCOc4ccc5[nH]cc(CCN)c5c4)cc23)CC1 | 10.1016/s0960-894x(98)00222-4 | |||
| CHEMBL31217 | 105512 | 0 | None | -1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 444 | 8 | 2 | 5 | 4.0 | CN1CCN(c2cccc3ccc(OCCOc4ccc5[nH]cc(CCN)c5c4)cc23)CC1 | 10.1016/s0960-894x(98)00222-4 | |||
| 44279525 | 105512 | 0 | None | -1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 444 | 8 | 2 | 5 | 4.0 | CN1CCN(c2cccc3ccc(OCCOc4ccc5[nH]cc(CCN)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
| CHEMBL31217 | 105512 | 0 | None | -1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 444 | 8 | 2 | 5 | 4.0 | CN1CCN(c2cccc3ccc(OCCOc4ccc5[nH]cc(CCN)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
| 24881689 | 170132 | 0 | None | 1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 554 | 8 | 4 | 4 | 6.0 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
| CHEMBL444404 | 170132 | 0 | None | 1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 554 | 8 | 4 | 4 | 6.0 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
| 24881203 | 173231 | 0 | None | 1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 624 | 13 | 4 | 4 | 8.0 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
| CHEMBL452387 | 173231 | 0 | None | 1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 624 | 13 | 4 | 4 | 8.0 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
| 11655728 | 16644 | 8 | None | -16 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 468 | 5 | 1 | 7 | 3.1 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
| CHEMBL1241913 | 16644 | 8 | None | -16 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 468 | 5 | 1 | 7 | 3.1 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
| 10275633 | 91954 | 0 | None | -1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 449 | 6 | 1 | 5 | 4.3 | Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
| CHEMBL241463 | 91954 | 0 | None | -1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 449 | 6 | 1 | 5 | 4.3 | Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
| 49850870 | 56389 | 0 | None | -6 | 9 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 424 | 6 | 1 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| CHEMBL1631535 | 56389 | 0 | None | -6 | 9 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 424 | 6 | 1 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| 10048342 | 186832 | 0 | None | -1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 430 | 5 | 0 | 5 | 3.7 | CCN1C(=O)COc2ccc(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cc21 | 10.1016/j.bmcl.2008.08.084 | |||
| CHEMBL489393 | 186832 | 0 | None | -1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 430 | 5 | 0 | 5 | 3.7 | CCN1C(=O)COc2ccc(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cc21 | 10.1016/j.bmcl.2008.08.084 | |||
| 10023176 | 186946 | 0 | None | -3 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 388 | 4 | 1 | 5 | 2.9 | O=C1COc2ccc(CCN3CCN(c4nccc5ccccc45)CC3)cc2N1 | 10.1016/j.bmcl.2008.08.084 | |||
| CHEMBL490211 | 186946 | 0 | None | -3 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 388 | 4 | 1 | 5 | 2.9 | O=C1COc2ccc(CCN3CCN(c4nccc5ccccc45)CC3)cc2N1 | 10.1016/j.bmcl.2008.08.084 | |||
| 44580783 | 193160 | 0 | None | 31 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 414 | 4 | 1 | 5 | 3.4 | Cc1ccc2c(N3C[C@H]4C[C@@H]3CN4CCc3ccc4c(c3)NC(=O)CO4)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
| CHEMBL523064 | 193160 | 0 | None | 31 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 414 | 4 | 1 | 5 | 3.4 | Cc1ccc2c(N3C[C@H]4C[C@@H]3CN4CCc3ccc4c(c3)NC(=O)CO4)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
| 44404241 | 133444 | 1 | None | 5 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 423 | 2 | 0 | 5 | 3.7 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2cccc3ncccc23)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
| CHEMBL370625 | 133444 | 1 | None | 5 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 423 | 2 | 0 | 5 | 3.7 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2cccc3ncccc23)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
| 10385855 | 14425 | 0 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 392 | 6 | 2 | 4 | 2.7 | Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL120055 | 14425 | 0 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 392 | 6 | 2 | 4 | 2.7 | Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL321818 | 14425 | 0 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 392 | 6 | 2 | 4 | 2.7 | Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| 24881264 | 188307 | 0 | None | 13 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 709 | 19 | 4 | 4 | 10.3 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
| CHEMBL500488 | 188307 | 0 | None | 13 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 709 | 19 | 4 | 4 | 10.3 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
| 59636727 | 125688 | 0 | None | - | 1 | Chinese hamster | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 364 | 5 | 1 | 5 | 2.6 | CNC(=O)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| CHEMBL3647270 | 125688 | 0 | None | - | 1 | Chinese hamster | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 364 | 5 | 1 | 5 | 2.6 | CNC(=O)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| 59636707 | 125686 | 0 | None | - | 1 | Chinese hamster | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 484 | 7 | 1 | 7 | 3.9 | O=C(NCc1ccc2c(c1)OCO2)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| CHEMBL3647268 | 125686 | 0 | None | - | 1 | Chinese hamster | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 484 | 7 | 1 | 7 | 3.9 | O=C(NCc1ccc2c(c1)OCO2)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| 22184652 | 85052 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 491 | 5 | 2 | 7 | 2.8 | COc1cc(N2CCCN(C)CC2)c2[nH]c(C(=O)Nc3ccc(N4CCOCC4)cc3)cc(=O)c2c1 | 10.1016/j.bmc.2006.10.037 | |||
| CHEMBL224195 | 85052 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 491 | 5 | 2 | 7 | 2.8 | COc1cc(N2CCCN(C)CC2)c2[nH]c(C(=O)Nc3ccc(N4CCOCC4)cc3)cc(=O)c2c1 | 10.1016/j.bmc.2006.10.037 | |||
| 124 | 2981 | 47 | None | -2 | 33 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | nan | |||
| 2032 | 2981 | 47 | None | -2 | 33 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | nan | |||
| 4636 | 2981 | 47 | None | -2 | 33 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | nan | |||
| CHEMBL762 | 2981 | 47 | None | -2 | 33 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | nan | |||
| DB00935 | 2981 | 47 | None | -2 | 33 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | nan | |||
| 45104862 | 200835 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 494 | 5 | 1 | 7 | 4.2 | COC1(c2ccc(NC(=O)C3CCc4cc(F)cc(-c5c(C)nn(C)c5C)c4O3)cn2)CCOCC1 | 10.1021/jm901200t | |||
| CHEMBL601013 | 200835 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 494 | 5 | 1 | 7 | 4.2 | COC1(c2ccc(NC(=O)C3CCc4cc(F)cc(-c5c(C)nn(C)c5C)c4O3)cn2)CCOCC1 | 10.1021/jm901200t | |||
| 45104862 | 200835 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 494 | 5 | 1 | 7 | 4.2 | COC1(c2ccc(NC(=O)C3CCc4cc(F)cc(-c5c(C)nn(C)c5C)c4O3)cn2)CCOCC1 | 10.1021/jm901200t | |||
| CHEMBL601013 | 200835 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 494 | 5 | 1 | 7 | 4.2 | COC1(c2ccc(NC(=O)C3CCc4cc(F)cc(-c5c(C)nn(C)c5C)c4O3)cn2)CCOCC1 | 10.1021/jm901200t | |||
| 107780 | 1844 | 54 | None | 1 | 17 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm970457s | |||
| 14 | 1844 | 54 | None | 1 | 17 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm970457s | |||
| CHEMBL15928 | 1844 | 54 | None | 1 | 17 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm970457s | |||
| 28 | 3496 | 46 | None | 13 | 10 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm970457s | |||
| 3292447 | 3496 | 46 | None | 13 | 10 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm970457s | |||
| CHEMBL20963 | 3496 | 46 | None | 13 | 10 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm970457s | |||
| 10802304 | 108536 | 1 | None | 4 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 274 | 9 | 2 | 2 | 4.0 | CCCCCCCOc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
| CHEMBL320079 | 108536 | 1 | None | 4 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 274 | 9 | 2 | 2 | 4.0 | CCCCCCCOc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
| 10613373 | 111305 | 1 | None | -1 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 288 | 10 | 2 | 2 | 4.4 | CCCCCCCCOc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
| CHEMBL326667 | 111305 | 1 | None | -1 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 288 | 10 | 2 | 2 | 4.4 | CCCCCCCCOc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
| 49850669 | 56387 | 0 | None | -5 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 483 | 6 | 2 | 4 | 5.7 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5ccccc5F)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| CHEMBL1631533 | 56387 | 0 | None | -5 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 483 | 6 | 2 | 4 | 5.7 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5ccccc5F)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| 10454807 | 186833 | 0 | None | -5 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 420 | 4 | 1 | 5 | 3.4 | Cc1ccc2c(N3CCN(CCc4cc(F)c5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
| CHEMBL489394 | 186833 | 0 | None | -5 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 420 | 4 | 1 | 5 | 3.4 | Cc1ccc2c(N3CCN(CCc4cc(F)c5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
| 59636767 | 125704 | 0 | None | - | 1 | Chinese hamster | 9.0 | pKi | = | 9 | Binding | ChEMBL | 470 | 8 | 1 | 6 | 4.1 | COc1ccc(CNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)cc1 | nan | |||
| CHEMBL3647286 | 125704 | 0 | None | - | 1 | Chinese hamster | 9.0 | pKi | = | 9 | Binding | ChEMBL | 470 | 8 | 1 | 6 | 4.1 | COc1ccc(CNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)cc1 | nan | |||
| 44404268 | 72153 | 0 | None | 1 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 517 | 4 | 0 | 7 | 4.3 | CCc1c(C(=O)N2CCc3cc4ccnc(N5CCN6CCC[C@@H]6C5)c4cc32)cnn1-c1ccc(C#N)cc1 | 10.1016/j.bmcl.2005.06.042 | |||
| CHEMBL197947 | 72153 | 0 | None | 1 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 517 | 4 | 0 | 7 | 4.3 | CCc1c(C(=O)N2CCc3cc4ccnc(N5CCN6CCC[C@@H]6C5)c4cc32)cnn1-c1ccc(C#N)cc1 | 10.1016/j.bmcl.2005.06.042 | |||
| 9957274 | 135301 | 0 | None | -1 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 491 | 4 | 0 | 7 | 3.8 | CCc1c(C(=O)N2CCc3cc4ccnc(N5CCN(C)CC5)c4cc32)cnn1-c1ccc(C#N)cc1 | 10.1016/j.bmcl.2005.06.042 | |||
| CHEMBL372743 | 135301 | 0 | None | -1 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 491 | 4 | 0 | 7 | 3.8 | CCc1c(C(=O)N2CCc3cc4ccnc(N5CCN(C)CC5)c4cc32)cnn1-c1ccc(C#N)cc1 | 10.1016/j.bmcl.2005.06.042 | |||
| 44404249 | 140361 | 0 | None | -3 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 412 | 2 | 0 | 6 | 2.8 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2cnn3ccccc23)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
| CHEMBL380812 | 140361 | 0 | None | -3 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 412 | 2 | 0 | 6 | 2.8 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2cnn3ccccc23)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
| 5 | 139 | 72 | None | -13 | 54 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm970645i | |||
| 5202 | 139 | 72 | None | -13 | 54 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm970645i | |||
| CHEMBL39 | 139 | 72 | None | -13 | 54 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm970645i | |||
| DB08839 | 139 | 72 | None | -13 | 54 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm970645i | |||
| 5 | 139 | 72 | None | -13 | 54 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm981112s | |||
| 5202 | 139 | 72 | None | -13 | 54 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm981112s | |||
| CHEMBL39 | 139 | 72 | None | -13 | 54 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm981112s | |||
| DB08839 | 139 | 72 | None | -13 | 54 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm981112s | |||
| 10665156 | 108979 | 0 | None | 8 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 344 | 11 | 1 | 3 | 4.9 | CCCCCCCCC(=O)Oc1ccc2[nH]cc(CCN(C)C)c2c1 | 10.1021/jm950498t | |||
| CHEMBL321190 | 108979 | 0 | None | 8 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 344 | 11 | 1 | 3 | 4.9 | CCCCCCCCC(=O)Oc1ccc2[nH]cc(CCN(C)C)c2c1 | 10.1021/jm950498t | |||
| 5 | 139 | 72 | None | -11 | 54 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm7011722 | |||
| 5202 | 139 | 72 | None | -11 | 54 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm7011722 | |||
| CHEMBL39 | 139 | 72 | None | -11 | 54 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm7011722 | |||
| DB08839 | 139 | 72 | None | -11 | 54 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm7011722 | |||
| 59636758 | 125678 | 0 | None | - | 1 | Chinese hamster | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 511 | 7 | 1 | 7 | 4.3 | O=C(Nc1ccc(N2CCOCC2)cc1)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| CHEMBL3647260 | 125678 | 0 | None | - | 1 | Chinese hamster | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 511 | 7 | 1 | 7 | 4.3 | O=C(Nc1ccc(N2CCOCC2)cc1)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| 106 | 148 | 26 | None | 4 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 302 | 11 | 2 | 2 | 4.8 | CCCCCCCCCOc1ccc2c(c1)c(CCN)c[nH]2 | 10.1021/jm00044a001 | |||
| 1797 | 148 | 26 | None | 4 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 302 | 11 | 2 | 2 | 4.8 | CCCCCCCCCOc1ccc2c(c1)c(CCN)c[nH]2 | 10.1021/jm00044a001 | |||
| CHEMBL97450 | 148 | 26 | None | 4 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 302 | 11 | 2 | 2 | 4.8 | CCCCCCCCCOc1ccc2c(c1)c(CCN)c[nH]2 | 10.1021/jm00044a001 | |||
| 1809 | 134 | 32 | None | -15 | 36 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm0341204 | |||
| 4 | 134 | 32 | None | -15 | 36 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm0341204 | |||
| CHEMBL18840 | 134 | 32 | None | -15 | 36 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm0341204 | |||
| 49850673 | 56392 | 0 | None | -10 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 418 | 6 | 1 | 5 | 4.5 | CCOC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
| CHEMBL1631538 | 56392 | 0 | None | -10 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 418 | 6 | 1 | 5 | 4.5 | CCOC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
| 49852001 | 56459 | 0 | None | -6 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 402 | 6 | 1 | 4 | 4.3 | CCC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
| CHEMBL1632207 | 56459 | 0 | None | -6 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 402 | 6 | 1 | 4 | 4.3 | CCC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
| 49850567 | 56469 | 0 | None | -6 | 9 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 452 | 6 | 1 | 6 | 4.0 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cnccn5)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| CHEMBL1632217 | 56469 | 0 | None | -6 | 9 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 452 | 6 | 1 | 6 | 4.0 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cnccn5)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| 49850570 | 56472 | 0 | None | -7 | 9 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 417 | 6 | 2 | 4 | 4.0 | CCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
| CHEMBL1632220 | 56472 | 0 | None | -7 | 9 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 417 | 6 | 2 | 4 | 4.0 | CCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
| 44580740 | 187762 | 0 | None | 1 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 416 | 4 | 1 | 5 | 3.6 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)[C@@H](C)C3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
| CHEMBL495703 | 187762 | 0 | None | 1 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 416 | 4 | 1 | 5 | 3.6 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)[C@@H](C)C3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
| 10174199 | 187693 | 0 | None | -3 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 481 | 9 | 1 | 5 | 5.0 | Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(=O)(=O)C(C)C)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
| CHEMBL495213 | 187693 | 0 | None | -3 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 481 | 9 | 1 | 5 | 5.0 | Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(=O)(=O)C(C)C)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
| 44404236 | 70556 | 0 | None | 1 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 406 | 2 | 0 | 4 | 3.8 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccccc2Cl)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
| CHEMBL194809 | 70556 | 0 | None | 1 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 406 | 2 | 0 | 4 | 3.8 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccccc2Cl)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
| 1042 | 1581 | 23 | None | -5 | 17 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | nan | |||
| 148 | 1581 | 23 | None | -5 | 17 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | nan | |||
| 443884 | 1581 | 23 | None | -5 | 17 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | nan | |||
| CHEMBL119443 | 1581 | 23 | None | -5 | 17 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | nan | |||
| DB01253 | 1581 | 23 | None | -5 | 17 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | nan | |||
| 19066163 | 11386 | 0 | None | 28 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 437 | 4 | 1 | 5 | 3.4 | COc1ccc(NC(=O)N2CCN(c3c(C)cccc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL111302 | 11386 | 0 | None | 28 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 437 | 4 | 1 | 5 | 3.4 | COc1ccc(NC(=O)N2CCN(c3c(C)cccc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL1180017 | 11386 | 0 | None | 28 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 437 | 4 | 1 | 5 | 3.4 | COc1ccc(NC(=O)N2CCN(c3c(C)cccc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| 24881752 | 171759 | 0 | None | -1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 638 | 14 | 4 | 4 | 8.4 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
| CHEMBL446745 | 171759 | 0 | None | -1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 638 | 14 | 4 | 4 | 8.4 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
| 24881202 | 172586 | 0 | None | -1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 596 | 11 | 4 | 4 | 7.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
| CHEMBL448902 | 172586 | 0 | None | -1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 596 | 11 | 4 | 4 | 7.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
| 59636755 | 126212 | 0 | None | - | 1 | Chinese hamster | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 392 | 5 | 0 | 5 | 3.2 | Cc1ccc(CCN2CCN(c3cccc4cc(C(=O)N(C)C)oc34)CC2)nc1 | nan | |||
| CHEMBL3650033 | 126212 | 0 | None | - | 1 | Chinese hamster | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 392 | 5 | 0 | 5 | 3.2 | Cc1ccc(CCN2CCN(c3cccc4cc(C(=O)N(C)C)oc34)CC2)nc1 | nan | |||
| 196129 | 67798 | 17 | None | -1 | 15 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 917 | 13 | 4 | 16 | 4.3 | CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC | nan | |||
| CHEMBL1909065 | 67798 | 17 | None | -1 | 15 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 917 | 13 | 4 | 16 | 4.3 | CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC | nan | |||
| 59636746 | 125699 | 0 | None | - | 1 | Chinese hamster | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 502 | 6 | 0 | 8 | 3.6 | O=C(c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1)N1CCN(c2nccs2)CC1 | nan | |||
| CHEMBL3647281 | 125699 | 0 | None | - | 1 | Chinese hamster | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 502 | 6 | 0 | 8 | 3.6 | O=C(c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1)N1CCN(c2nccs2)CC1 | nan | |||
| 59636781 | 126218 | 0 | None | - | 1 | Chinese hamster | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 408 | 6 | 0 | 6 | 2.9 | COc1cccc(CCN2CCN(c3cccc4cc(C(=O)N(C)C)oc34)CC2)n1 | nan | |||
| CHEMBL3650039 | 126218 | 0 | None | - | 1 | Chinese hamster | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 408 | 6 | 0 | 6 | 2.9 | COc1cccc(CCN2CCN(c3cccc4cc(C(=O)N(C)C)oc34)CC2)n1 | nan | |||
| 10791125 | 18961 | 0 | None | 1 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 486 | 5 | 0 | 5 | 4.2 | Cc1cc(C)c(N2CCN(C(=O)COc3ccc4cccc(N5CCN(C)CC5)c4c3)CC2)c(C)c1 | 10.1021/jm9703552 | |||
| CHEMBL128699 | 18961 | 0 | None | 1 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 486 | 5 | 0 | 5 | 4.2 | Cc1cc(C)c(N2CCN(C(=O)COc3ccc4cccc(N5CCN(C)CC5)c4c3)CC2)c(C)c1 | 10.1021/jm9703552 | |||
| 44342784 | 9827 | 0 | None | -3 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 444 | 4 | 2 | 2 | 5.8 | Cc1ccc(/N=C(\S)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1 | 10.1016/s0960-894x(03)00779-0 | |||
| CHEMBL113950 | 9827 | 0 | None | -3 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 444 | 4 | 2 | 2 | 5.8 | Cc1ccc(/N=C(\S)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1 | 10.1016/s0960-894x(03)00779-0 | |||
| 44342506 | 10125 | 0 | None | -2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 464 | 4 | 2 | 2 | 6.2 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(/C(S)=N/c4ccc(Cl)cc4)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
| CHEMBL115663 | 10125 | 0 | None | -2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 464 | 4 | 2 | 2 | 6.2 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(/C(S)=N/c4ccc(Cl)cc4)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
| 44402887 | 71734 | 0 | None | 79 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 479 | 4 | 0 | 4 | 4.5 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Cc1cccc(C(F)(F)F)c1F)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| CHEMBL196600 | 71734 | 0 | None | 79 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 479 | 4 | 0 | 4 | 4.5 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Cc1cccc(C(F)(F)F)c1F)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| 10577268 | 82389 | 0 | None | 15 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 498 | 8 | 1 | 7 | 5.1 | Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4cc5c(c(OCCN(C)C)c4)OCC5)cc3)c(C)c2)no1 | 10.1021/jm970457s | |||
| CHEMBL21724 | 82389 | 0 | None | 15 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 498 | 8 | 1 | 7 | 5.1 | Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4cc5c(c(OCCN(C)C)c4)OCC5)cc3)c(C)c2)no1 | 10.1021/jm970457s | |||
| 49850772 | 56399 | 0 | None | -10 | 9 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 397 | 5 | 0 | 5 | 4.1 | Cc1ccc2c(N3CCN(CCc4cccc(-n5cccn5)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| CHEMBL1631545 | 56399 | 0 | None | -10 | 9 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 397 | 5 | 0 | 5 | 4.1 | Cc1ccc2c(N3CCN(CCc4cccc(-n5cccn5)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| 49852002 | 56460 | 0 | None | -10 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 416 | 6 | 1 | 4 | 4.5 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)C(C)C)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| CHEMBL1632208 | 56460 | 0 | None | -10 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 416 | 6 | 1 | 4 | 4.5 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)C(C)C)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| 49850984 | 56467 | 0 | None | -10 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 480 | 7 | 1 | 5 | 5.2 | COc1cccc(C(=O)Nc2cccc(CCN3CCN(c4cccc5nc(C)ccc45)CC3)c2)c1 | 10.1021/jm100714c | |||
| CHEMBL1632215 | 56467 | 0 | None | -10 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 480 | 7 | 1 | 5 | 5.2 | COc1cccc(C(=O)Nc2cccc(CCN3CCN(c4cccc5nc(C)ccc45)CC3)c2)c1 | 10.1021/jm100714c | |||
| 44443131 | 93810 | 0 | None | -3 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 464 | 6 | 0 | 6 | 3.2 | Cc1ccc2c(OCCN3CCN(Cc4ccc5c(c4F)N(C)C(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2007.06.078 | |||
| CHEMBL247609 | 93810 | 0 | None | -3 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 464 | 6 | 0 | 6 | 3.2 | Cc1ccc2c(OCCN3CCN(Cc4ccc5c(c4F)N(C)C(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2007.06.078 | |||
| 44443132 | 169484 | 0 | None | -1 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 478 | 7 | 0 | 6 | 3.6 | CCN1C(=O)COc2ccc(CN3CCN(CCOc4cccc5nc(C)ccc45)CC3)c(F)c21 | 10.1016/j.bmcl.2007.06.078 | |||
| CHEMBL443060 | 169484 | 0 | None | -1 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 478 | 7 | 0 | 6 | 3.6 | CCN1C(=O)COc2ccc(CN3CCN(CCOc4cccc5nc(C)ccc45)CC3)c(F)c21 | 10.1016/j.bmcl.2007.06.078 | |||
| 10387420 | 187854 | 0 | None | -6 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 420 | 4 | 1 | 5 | 3.4 | Cc1ccc2c(N3CCN(CCc4cc5c(cc4F)OCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
| CHEMBL496317 | 187854 | 0 | None | -6 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 420 | 4 | 1 | 5 | 3.4 | Cc1ccc2c(N3CCN(CCc4cc5c(cc4F)OCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
| 44404258 | 166159 | 0 | None | 1 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 505 | 5 | 0 | 7 | 4.2 | CCc1c(C(=O)N2CCc3cc4ccnc(N5CCN(CC)CC5)c4cc32)cnn1-c1ccc(C#N)cc1 | 10.1016/j.bmcl.2005.06.042 | |||
| CHEMBL426285 | 166159 | 0 | None | 1 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 505 | 5 | 0 | 7 | 4.2 | CCc1c(C(=O)N2CCc3cc4ccnc(N5CCN(CC)CC5)c4cc32)cnn1-c1ccc(C#N)cc1 | 10.1016/j.bmcl.2005.06.042 | |||
| 10848041 | 9374 | 1 | None | -1 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 246 | 7 | 2 | 2 | 3.2 | CCCCCOc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
| CHEMBL111376 | 9374 | 1 | None | -1 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 246 | 7 | 2 | 2 | 3.2 | CCCCCOc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
| 49836002 | 126210 | 0 | None | - | 1 | Chinese hamster | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 460 | 5 | 0 | 5 | 3.4 | CC(=O)N1CCc2cc(CCN3CCN(c4cccc5cc(C(=O)N(C)C)oc45)CC3)ccc21 | nan | |||
| CHEMBL3650031 | 126210 | 0 | None | - | 1 | Chinese hamster | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 460 | 5 | 0 | 5 | 3.4 | CC(=O)N1CCc2cc(CCN3CCN(c4cccc5cc(C(=O)N(C)C)oc45)CC3)ccc21 | nan | |||
| 9830790 | 201060 | 1 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 521 | 5 | 1 | 7 | 3.0 | CCC(=O)N1CCN(c2ccc(NC(=O)c3cc(=O)c4cc(F)cc(N5CCN(C)CC5)c4o3)cc2)CC1 | 10.1021/jm901200t | |||
| CHEMBL602674 | 201060 | 1 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 521 | 5 | 1 | 7 | 3.0 | CCC(=O)N1CCN(c2ccc(NC(=O)c3cc(=O)c4cc(F)cc(N5CCN(C)CC5)c4o3)cc2)CC1 | 10.1021/jm901200t | |||
| 9830790 | 201060 | 1 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 521 | 5 | 1 | 7 | 3.0 | CCC(=O)N1CCN(c2ccc(NC(=O)c3cc(=O)c4cc(F)cc(N5CCN(C)CC5)c4o3)cc2)CC1 | 10.1021/jm901200t | |||
| CHEMBL602674 | 201060 | 1 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 521 | 5 | 1 | 7 | 3.0 | CCC(=O)N1CCN(c2ccc(NC(=O)c3cc(=O)c4cc(F)cc(N5CCN(C)CC5)c4o3)cc2)CC1 | 10.1021/jm901200t | |||
| 19066203 | 12089 | 0 | None | 47 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 437 | 4 | 1 | 5 | 3.4 | COc1ccc(NC(=O)N2CCN(c3ccc(C)cc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL1183904 | 12089 | 0 | None | 47 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 437 | 4 | 1 | 5 | 3.4 | COc1ccc(NC(=O)N2CCN(c3ccc(C)cc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL323986 | 12089 | 0 | None | 47 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 437 | 4 | 1 | 5 | 3.4 | COc1ccc(NC(=O)N2CCN(c3ccc(C)cc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| 59636750 | 125680 | 0 | None | - | 1 | Chinese hamster | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 518 | 8 | 1 | 7 | 3.5 | CS(=O)(=O)c1ccc(CNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)cc1 | nan | |||
| CHEMBL3647262 | 125680 | 0 | None | - | 1 | Chinese hamster | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 518 | 8 | 1 | 7 | 3.5 | CS(=O)(=O)c1ccc(CNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)cc1 | nan | |||
| 59636703 | 125685 | 0 | None | - | 1 | Chinese hamster | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 465 | 7 | 1 | 6 | 4.0 | N#Cc1ccc(CNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)cc1 | nan | |||
| CHEMBL3647267 | 125685 | 0 | None | - | 1 | Chinese hamster | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 465 | 7 | 1 | 6 | 4.0 | N#Cc1ccc(CNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)cc1 | nan | |||
| 44403095 | 135234 | 0 | None | 3 | 6 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 443 | 4 | 1 | 5 | 3.5 | COc1ccc(NC(=O)N2CCN(c3ccc(Cl)cc3)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
| CHEMBL372453 | 135234 | 0 | None | 3 | 6 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 443 | 4 | 1 | 5 | 3.5 | COc1ccc(NC(=O)N2CCN(c3ccc(Cl)cc3)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
| 10376578 | 121079 | 3 | None | -4 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 230 | 3 | 2 | 1 | 3.2 | CNCCc1c[nH]c2ccc(C(C)(C)C)cc12 | 10.1021/jm9805945 | |||
| CHEMBL357034 | 121079 | 3 | None | -4 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 230 | 3 | 2 | 1 | 3.2 | CNCCc1c[nH]c2ccc(C(C)(C)C)cc12 | 10.1021/jm9805945 | |||
| 44402876 | 70888 | 0 | None | 6 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 492 | 4 | 0 | 5 | 5.2 | COc1cc2c(cc1N1CCN(C)CC1)N(C(=O)c1ccc(-c3cccc(C)n3)c3ccccc13)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| CHEMBL195114 | 70888 | 0 | None | 6 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 492 | 4 | 0 | 5 | 5.2 | COc1cc2c(cc1N1CCN(C)CC1)N(C(=O)c1ccc(-c3cccc(C)n3)c3ccccc13)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| 44402879 | 71408 | 0 | None | 50 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 445 | 4 | 0 | 4 | 4.1 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Cc1cccc(Cl)c1F)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| CHEMBL195898 | 71408 | 0 | None | 50 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 445 | 4 | 0 | 4 | 4.1 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Cc1cccc(Cl)c1F)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| 11304596 | 56396 | 0 | None | -12 | 9 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 416 | 5 | 0 | 5 | 3.9 | Cc1ccc2c(N3CCN(CCc4cccc(N5CCOC5=O)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| CHEMBL1631542 | 56396 | 0 | None | -12 | 9 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 416 | 5 | 0 | 5 | 3.9 | Cc1ccc2c(N3CCN(CCc4cccc(N5CCOC5=O)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| 49852000 | 56400 | 0 | None | -3 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 452 | 8 | 1 | 5 | 4.1 | CCCS(=O)(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
| CHEMBL1631548 | 56400 | 0 | None | -3 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 452 | 8 | 1 | 5 | 4.1 | CCCS(=O)(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
| 49852003 | 56461 | 0 | None | -6 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 430 | 5 | 1 | 4 | 4.9 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)C(C)(C)C)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| CHEMBL1632209 | 56461 | 0 | None | -6 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 430 | 5 | 1 | 4 | 4.9 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)C(C)(C)C)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| 49850569 | 56471 | 0 | None | -7 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 4.9 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5scnc5C)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| CHEMBL1632219 | 56471 | 0 | None | -7 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 4.9 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5scnc5C)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| 49850571 | 56473 | 0 | None | -12 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 431 | 7 | 2 | 4 | 4.4 | CCCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
| CHEMBL1632221 | 56473 | 0 | None | -12 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 431 | 7 | 2 | 4 | 4.4 | CCCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
| 24865725 | 188084 | 0 | None | -3 | 12 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 453 | 8 | 1 | 5 | 4.2 | Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| CHEMBL497963 | 188084 | 0 | None | -3 | 12 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 453 | 8 | 1 | 5 | 4.2 | Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| 10127424 | 176055 | 0 | None | -1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 443 | 7 | 0 | 4 | 5.9 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCCC5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| CHEMBL459061 | 176055 | 0 | None | -1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 443 | 7 | 0 | 4 | 5.9 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCCC5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| 10319737 | 187763 | 0 | None | -6 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 416 | 4 | 1 | 5 | 3.6 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3C)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
| CHEMBL495705 | 187763 | 0 | None | -6 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 416 | 4 | 1 | 5 | 3.6 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3C)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
| 24865725 | 188084 | 0 | None | -3 | 12 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 453 | 8 | 1 | 5 | 4.2 | Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| CHEMBL497963 | 188084 | 0 | None | -3 | 12 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 453 | 8 | 1 | 5 | 4.2 | Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| 10238566 | 190028 | 0 | None | -3 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.7 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCN[C@H](C)C5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| CHEMBL517170 | 190028 | 0 | None | -3 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.7 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCN[C@H](C)C5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| 24865725 | 188084 | 0 | None | -3 | 12 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 453 | 8 | 1 | 5 | 4.2 | Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
| CHEMBL497963 | 188084 | 0 | None | -3 | 12 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 453 | 8 | 1 | 5 | 4.2 | Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
| 44404244 | 72551 | 0 | None | 2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 444 | 2 | 0 | 5 | 4.1 | Cc1cc(C(=O)N2CCc3cc4ccnc(N5CCN(C)CC5)c4cc32)c(C(F)(F)F)o1 | 10.1016/j.bmcl.2005.06.042 | |||
| CHEMBL199175 | 72551 | 0 | None | 2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 444 | 2 | 0 | 5 | 4.1 | Cc1cc(C(=O)N2CCc3cc4ccnc(N5CCN(C)CC5)c4cc32)c(C(F)(F)F)o1 | 10.1016/j.bmcl.2005.06.042 | |||
| 44404272 | 140891 | 0 | None | -1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 517 | 4 | 0 | 7 | 4.3 | CCc1c(C(=O)N2CCc3cc4ccnc(N5CCN6CCC[C@H]6C5)c4cc32)cnn1-c1ccc(C#N)cc1 | 10.1016/j.bmcl.2005.06.042 | |||
| CHEMBL382078 | 140891 | 0 | None | -1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 517 | 4 | 0 | 7 | 4.3 | CCc1c(C(=O)N2CCc3cc4ccnc(N5CCN6CCC[C@H]6C5)c4cc32)cnn1-c1ccc(C#N)cc1 | 10.1016/j.bmcl.2005.06.042 | |||
| 130 | 3500 | 47 | None | -1 | 13 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1016/S0960-894X(97)10164-0 | |||
| 3378093 | 3500 | 47 | None | -1 | 13 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL281350 | 3500 | 47 | None | -1 | 13 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1016/S0960-894X(97)10164-0 | |||
| 2389 | 3331 | 118 | None | -93 | 67 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | |||
| 5073 | 3331 | 118 | None | -93 | 67 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | |||
| 96 | 3331 | 118 | None | -93 | 67 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | |||
| CHEMBL85 | 3331 | 118 | None | -93 | 67 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | |||
| DB00734 | 3331 | 118 | None | -93 | 67 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | |||
| 2543 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm950498t | |||
| 5358 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm950498t | |||
| 54 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm950498t | |||
| CHEMBL128 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm950498t | |||
| DB00669 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm950498t | |||
| 127036 | 9360 | 12 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 229 | 1 | 3 | 2 | 1.1 | NC(=O)c1ccc2[nH]c3c(c2c1)CC(N)CC3 | 10.1021/jm950498t | |||
| CHEMBL111316 | 9360 | 12 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 229 | 1 | 3 | 2 | 1.1 | NC(=O)c1ccc2[nH]c3c(c2c1)CC(N)CC3 | 10.1021/jm950498t | |||
| 10296414 | 3531 | 15 | None | -7 | 9 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1021/jm049039v | |||
| 76 | 3531 | 15 | None | -7 | 9 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1021/jm049039v | |||
| CHEMBL183460 | 3531 | 15 | None | -7 | 9 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1021/jm049039v | |||
| 10296414 | 3531 | 15 | None | -7 | 9 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1016/j.bmcl.2006.11.031 | |||
| 76 | 3531 | 15 | None | -7 | 9 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1016/j.bmcl.2006.11.031 | |||
| CHEMBL183460 | 3531 | 15 | None | -7 | 9 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1016/j.bmcl.2006.11.031 | |||
| 10296414 | 3531 | 15 | None | -7 | 9 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1016/j.bmcl.2007.06.078 | |||
| 76 | 3531 | 15 | None | -7 | 9 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1016/j.bmcl.2007.06.078 | |||
| CHEMBL183460 | 3531 | 15 | None | -7 | 9 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1016/j.bmcl.2007.06.078 | |||
| 10296414 | 3531 | 15 | None | -7 | 9 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1016/j.bmcl.2008.08.110 | |||
| 76 | 3531 | 15 | None | -7 | 9 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1016/j.bmcl.2008.08.110 | |||
| CHEMBL183460 | 3531 | 15 | None | -7 | 9 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1016/j.bmcl.2008.08.110 | |||
| 10296414 | 3531 | 15 | None | -7 | 9 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1021/jm8001444 | |||
| 76 | 3531 | 15 | None | -7 | 9 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1021/jm8001444 | |||
| CHEMBL183460 | 3531 | 15 | None | -7 | 9 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 10.1021/jm8001444 | |||
| 130 | 3500 | 47 | None | -1 | 13 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1016/j.bmcl.2005.07.024 | |||
| 3378093 | 3500 | 47 | None | -1 | 13 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1016/j.bmcl.2005.07.024 | |||
| CHEMBL281350 | 3500 | 47 | None | -1 | 13 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1016/j.bmcl.2005.07.024 | |||
| 59636719 | 125695 | 0 | None | - | 1 | Chinese hamster | 8.0 | pKi | = | 8 | Binding | ChEMBL | 532 | 8 | 0 | 7 | 3.9 | CN(Cc1cccc(S(C)(=O)=O)c1)C(=O)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| CHEMBL3647277 | 125695 | 0 | None | - | 1 | Chinese hamster | 8.0 | pKi | = | 8 | Binding | ChEMBL | 532 | 8 | 0 | 7 | 3.9 | CN(Cc1cccc(S(C)(=O)=O)c1)C(=O)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| 2393 | 3334 | 82 | None | -1 | 5 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10.1021/jm9805945 | |||
| 5078 | 3334 | 82 | None | -1 | 5 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10.1021/jm9805945 | |||
| 51 | 3334 | 82 | None | -1 | 5 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10.1021/jm9805945 | |||
| CHEMBL905 | 3334 | 82 | None | -1 | 5 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10.1021/jm9805945 | |||
| DB00953 | 3334 | 82 | None | -1 | 5 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10.1021/jm9805945 | |||
| 1342 | 35 | 49 | None | -4 | 19 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 10.1021/jm9703552 | |||
| 3 | 35 | 49 | None | -4 | 19 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 10.1021/jm9703552 | |||
| CHEMBL277120 | 35 | 49 | None | -4 | 19 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 10.1021/jm9703552 | |||
| 1251 | 1692 | 30 | None | -1 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 243 | 2 | 4 | 2 | 2.1 | CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O | 10.1021/jm9805945 | |||
| 7191 | 1692 | 30 | None | -1 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 243 | 2 | 4 | 2 | 2.1 | CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O | 10.1021/jm9805945 | |||
| 77992 | 1692 | 30 | None | -1 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 243 | 2 | 4 | 2 | 2.1 | CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O | 10.1021/jm9805945 | |||
| CHEMBL1279 | 1692 | 30 | None | -1 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 243 | 2 | 4 | 2 | 2.1 | CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O | 10.1021/jm9805945 | |||
| DB00998 | 1692 | 30 | None | -1 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 243 | 2 | 4 | 2 | 2.1 | CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O | 10.1021/jm9805945 | |||
| 44292375 | 169174 | 0 | None | -36 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 256 | 3 | 1 | 1 | 3.9 | CC(C)c1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1 | 10.1016/s0960-894x(00)00322-x | |||
| CHEMBL44054 | 169174 | 0 | None | -36 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 256 | 3 | 1 | 1 | 3.9 | CC(C)c1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1 | 10.1016/s0960-894x(00)00322-x | |||
| 1342 | 35 | 49 | None | -4 | 19 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 10.1016/s0960-894x(98)00222-4 | |||
| 3 | 35 | 49 | None | -4 | 19 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 10.1016/s0960-894x(98)00222-4 | |||
| CHEMBL277120 | 35 | 49 | None | -4 | 19 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 10.1016/s0960-894x(98)00222-4 | |||
| 11071135 | 208008 | 0 | None | -45 | 7 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 500 | 6 | 0 | 6 | 4.6 | CN1CCC(CCN2CCC(c3cn(-c4ccc(F)cc4)c4ccc(-c5ncn(C)n5)cc34)CC2)C1=O | 10.1021/jm020938y | |||
| CHEMBL97333 | 208008 | 0 | None | -45 | 7 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 500 | 6 | 0 | 6 | 4.6 | CN1CCC(CCN2CCC(c3cn(-c4ccc(F)cc4)c4ccc(-c5ncn(C)n5)cc34)CC2)C1=O | 10.1021/jm020938y | |||
| 22132503 | 101980 | 0 | None | -25 | 4 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 521 | 9 | 2 | 5 | 4.4 | O=C(/C=C/c1c[nH]c2ccccc12)NCCCCN1CCc2ccc(OS(=O)(=O)C(F)(F)F)cc2C1 | 10.1021/jm000090i | |||
| CHEMBL301475 | 101980 | 0 | None | -25 | 4 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 521 | 9 | 2 | 5 | 4.4 | O=C(/C=C/c1c[nH]c2ccccc12)NCCCCN1CCc2ccc(OS(=O)(=O)C(F)(F)F)cc2C1 | 10.1021/jm000090i | |||
| CHEMBL552599 | 101980 | 0 | None | -25 | 4 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 521 | 9 | 2 | 5 | 4.4 | O=C(/C=C/c1c[nH]c2ccccc12)NCCCCN1CCc2ccc(OS(=O)(=O)C(F)(F)F)cc2C1 | 10.1021/jm000090i | |||
| 44400359 | 68685 | 0 | None | -10 | 3 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 432 | 6 | 0 | 7 | 3.0 | Cc1ccc2c(OCCN3CCN(CN4C=CC5=CC(=O)CC=C5O4)CC3)cccc2n1 | 10.1021/jm049039v | |||
| CHEMBL192176 | 68685 | 0 | None | -10 | 3 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 432 | 6 | 0 | 7 | 3.0 | Cc1ccc2c(OCCN3CCN(CN4C=CC5=CC(=O)CC=C5O4)CC3)cccc2n1 | 10.1021/jm049039v | |||
| 10159927 | 93970 | 0 | None | -10 | 3 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 432 | 6 | 1 | 6 | 3.1 | Cc1ccc2c(OCCN3CCN(Cc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2007.06.078 | |||
| CHEMBL248457 | 93970 | 0 | None | -10 | 3 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 432 | 6 | 1 | 6 | 3.1 | Cc1ccc2c(OCCN3CCN(Cc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2007.06.078 | |||
| 24881617 | 188326 | 0 | None | -165 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 756 | 13 | 4 | 4 | 10.1 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | 10.1021/jm7011722 | |||
| CHEMBL500737 | 188326 | 0 | None | -165 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 756 | 13 | 4 | 4 | 10.1 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | 10.1021/jm7011722 | |||
| 44593711 | 184323 | 0 | None | 1 | 3 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 445 | 6 | 1 | 5 | 4.6 | Cc1ccc2c(OCC(C)N3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.110 | |||
| CHEMBL484216 | 184323 | 0 | None | 1 | 3 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 445 | 6 | 1 | 5 | 4.6 | Cc1ccc2c(OCC(C)N3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.110 | |||
| 24865724 | 187964 | 0 | None | -63 | 3 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 445 | 8 | 0 | 4 | 5.3 | CCN(C(C)=O)c1cccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm8001444 | |||
| CHEMBL497127 | 187964 | 0 | None | -63 | 3 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 445 | 8 | 0 | 4 | 5.3 | CCN(C(C)=O)c1cccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm8001444 | |||
| 181743 | 178572 | 5 | None | -50 | 22 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 339 | 2 | 0 | 5 | 3.2 | COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4 | 10.1016/j.bmcl.2015.07.012 | |||
| CHEMBL467094 | 178572 | 5 | None | -50 | 22 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 339 | 2 | 0 | 5 | 3.2 | COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4 | 10.1016/j.bmcl.2015.07.012 | |||
| 181743 | 178572 | 5 | None | -50 | 22 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 339 | 2 | 0 | 5 | 3.2 | COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4 | 10.1016/j.bmcl.2009.11.053 | |||
| CHEMBL467094 | 178572 | 5 | None | -50 | 22 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 339 | 2 | 0 | 5 | 3.2 | COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4 | 10.1016/j.bmcl.2009.11.053 | |||
| 15124074 | 119697 | 0 | None | -14 | 3 | Rat | 7.0 | pKi | = | 7 | Binding | ChEMBL | 394 | 6 | 0 | 4 | 3.4 | CCc1ccccc1N1CCN(Cc2ccc(CN3CCCCC3=O)n2C)CC1 | 10.1021/jm00081a018 | |||
| CHEMBL347334 | 119697 | 0 | None | -14 | 3 | Rat | 7.0 | pKi | = | 7 | Binding | ChEMBL | 394 | 6 | 0 | 4 | 3.4 | CCc1ccccc1N1CCN(Cc2ccc(CN3CCCCC3=O)n2C)CC1 | 10.1021/jm00081a018 | |||
| 10811696 | 102482 | 0 | None | -316 | 4 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 413 | 6 | 1 | 3 | 4.7 | N#Cc1ccc2c(c1)CCN(CC[C@H]1CC[C@H](NC(=O)/C=C/c3ccccc3)CC1)C2 | 10.1021/jm000090i | |||
| CHEMBL2368612 | 102482 | 0 | None | -316 | 4 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 413 | 6 | 1 | 3 | 4.7 | N#Cc1ccc2c(c1)CCN(CC[C@H]1CC[C@H](NC(=O)/C=C/c3ccccc3)CC1)C2 | 10.1021/jm000090i | |||
| CHEMBL3040263 | 102482 | 0 | None | -316 | 4 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 413 | 6 | 1 | 3 | 4.7 | N#Cc1ccc2c(c1)CCN(CC[C@H]1CC[C@H](NC(=O)/C=C/c3ccccc3)CC1)C2 | 10.1021/jm000090i | |||
| 152 | 364 | 29 | None | -57 | 18 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 10.1021/jm00384a001 | |||
| 2107 | 364 | 29 | None | -57 | 18 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 10.1021/jm00384a001 | |||
| CHEMBL275854 | 364 | 29 | None | -57 | 18 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 10.1021/jm00384a001 | |||
| 5475158 | 67213 | 25 | None | -1023 | 14 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 340 | 8 | 1 | 3 | 4.4 | CN(C)CCCSc1ccccc1NC(=O)/C=C/c1ccccc1 | 10.1021/jm00384a001 | |||
| CHEMBL18786 | 67213 | 25 | None | -1023 | 14 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 340 | 8 | 1 | 3 | 4.4 | CN(C)CCCSc1ccccc1NC(=O)/C=C/c1ccccc1 | 10.1021/jm00384a001 | |||
| 10257042 | 204361 | 0 | None | -25 | 7 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 551 | 6 | 3 | 3 | 7.3 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@@H](CN2[C@H]3CC[C@@H]2C[C@@H](c2c[nH]c4ccc(O)cc24)C3)CC1 | 10.1016/s0960-894x(01)00397-3 | |||
| CHEMBL71707 | 204361 | 0 | None | -25 | 7 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 551 | 6 | 3 | 3 | 7.3 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@@H](CN2[C@H]3CC[C@@H]2C[C@@H](c2c[nH]c4ccc(O)cc24)C3)CC1 | 10.1016/s0960-894x(01)00397-3 | |||
| 242 | 470 | 124 | None | -380 | 51 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1039/C2MD00311B | |||
| 34 | 470 | 124 | None | -380 | 51 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1039/C2MD00311B | |||
| 60795 | 470 | 124 | None | -380 | 51 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1039/C2MD00311B | |||
| CHEMBL1112 | 470 | 124 | None | -380 | 51 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1039/C2MD00311B | |||
| DB01238 | 470 | 124 | None | -380 | 51 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1039/C2MD00311B | |||
| 135398737 | 958 | 93 | None | -151 | 89 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | |||
| 38 | 958 | 93 | None | -151 | 89 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | |||
| 722 | 958 | 93 | None | -151 | 89 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | |||
| CHEMBL42 | 958 | 93 | None | -151 | 89 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | |||
| DB00363 | 958 | 93 | None | -151 | 89 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | |||
| 135398745 | 2914 | 112 | None | -199 | 65 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C2MD00311B | |||
| 47 | 2914 | 112 | None | -199 | 65 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C2MD00311B | |||
| CHEMBL715 | 2914 | 112 | None | -199 | 65 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C2MD00311B | |||
| DB00334 | 2914 | 112 | None | -199 | 65 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C2MD00311B | |||
| 3233 | 3512 | 44 | None | -741 | 12 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm991151j | |||
| 3247 | 3512 | 44 | None | -741 | 12 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm991151j | |||
| 6604889 | 3512 | 44 | None | -741 | 12 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm991151j | |||
| CHEMBL282199 | 3512 | 44 | None | -741 | 12 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm991151j | |||
| DB13988 | 3512 | 44 | None | -741 | 12 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm991151j | |||
| 10573876 | 10462 | 0 | None | -501 | 7 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 414 | 5 | 0 | 3 | 3.7 | CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)CC1 | 10.1021/jm991151j | |||
| CHEMBL116448 | 10462 | 0 | None | -501 | 7 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 414 | 5 | 0 | 3 | 3.7 | CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)CC1 | 10.1021/jm991151j | |||
| 9934284 | 90296 | 0 | None | -2511 | 10 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 467 | 6 | 1 | 5 | 4.5 | Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(F)cc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
| CHEMBL238520 | 90296 | 0 | None | -2511 | 10 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 467 | 6 | 1 | 5 | 4.5 | Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(F)cc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
| 22326660 | 90771 | 0 | None | -50 | 3 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 456 | 6 | 1 | 6 | 4.1 | Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cc(C#N)cc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
| CHEMBL239167 | 90771 | 0 | None | -50 | 3 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 456 | 6 | 1 | 6 | 4.1 | Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cc(C#N)cc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
| 11046087 | 4947 | 0 | None | -134 | 4 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 340 | 3 | 2 | 4 | 3.7 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccsc4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL104753 | 4947 | 0 | None | -134 | 4 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 340 | 3 | 2 | 4 | 3.7 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccsc4)nc23)CC1 | 10.1021/jm030020m | |||
| 11110452 | 5130 | 0 | None | -158 | 4 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 335 | 3 | 2 | 4 | 3.0 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccn4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL105722 | 5130 | 0 | None | -158 | 4 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 335 | 3 | 2 | 4 | 3.0 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccn4)nc23)CC1 | 10.1021/jm030020m | |||
| 13520547 | 27004 | 1 | None | -2 | 3 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 243 | 6 | 0 | 2 | 3.6 | CN(C)CCCCOc1cccc2ccccc12 | 10.1021/jm00124a021 | |||
| CHEMBL136470 | 27004 | 1 | None | -2 | 3 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 243 | 6 | 0 | 2 | 3.6 | CN(C)CCCCOc1cccc2ccccc12 | 10.1021/jm00124a021 | |||
| 23274477 | 29121 | 1 | None | -3 | 3 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 229 | 5 | 0 | 2 | 3.2 | CN(C)CCCOc1cccc2ccccc12 | 10.1021/jm00124a021 | |||
| CHEMBL138136 | 29121 | 1 | None | -3 | 3 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 229 | 5 | 0 | 2 | 3.2 | CN(C)CCCOc1cccc2ccccc12 | 10.1021/jm00124a021 | |||
| 3198 | 205513 | 76 | None | -44 | 34 | Rat | 5.0 | pKi | = | 5 | Binding | ChEMBL | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | nan | |||
| CHEMBL1201049 | 205513 | 76 | None | -44 | 34 | Rat | 5.0 | pKi | = | 5 | Binding | ChEMBL | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | nan | |||
| CHEMBL808 | 205513 | 76 | None | -44 | 34 | Rat | 5.0 | pKi | = | 5 | Binding | ChEMBL | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | nan | |||
| 117209971 | 186485 | 1 | None | -20 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 258 | 3 | 2 | 4 | 1.5 | COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
| CHEMBL4877051 | 186485 | 1 | None | -20 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 258 | 3 | 2 | 4 | 1.5 | COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
| 1150 | 3878 | 121 | None | -204 | 25 | Rat | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 10.1021/jm00384a001 | |||
| 125 | 3878 | 121 | None | -204 | 25 | Rat | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 10.1021/jm00384a001 | |||
| CHEMBL6640 | 3878 | 121 | None | -204 | 25 | Rat | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 10.1021/jm00384a001 | |||
| DB08653 | 3878 | 121 | None | -204 | 25 | Rat | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 10.1021/jm00384a001 | |||
| 20255884 | 66063 | 0 | None | -30 | 2 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 234 | 2 | 2 | 5 | 1.6 | Cc1cc([N+](=O)[O-])cc(C)c1NC1=NCCN1 | 10.1016/j.bmcl.2004.06.085 | |||
| CHEMBL183704 | 66063 | 0 | None | -30 | 2 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 234 | 2 | 2 | 5 | 1.6 | Cc1cc([N+](=O)[O-])cc(C)c1NC1=NCCN1 | 10.1016/j.bmcl.2004.06.085 | |||
| 24881550 | 172746 | 0 | None | -4 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 726 | 10 | 4 | 4 | 9.0 | O=C(Nc1ccc2[nH]cc(C3CCN(C/C=C/CN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | 10.1021/jm7011722 | |||
| CHEMBL450852 | 172746 | 0 | None | -4 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 726 | 10 | 4 | 4 | 9.0 | O=C(Nc1ccc2[nH]cc(C3CCN(C/C=C/CN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | 10.1021/jm7011722 | |||
| 44431532 | 145237 | 0 | None | -14 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 447 | 5 | 1 | 4 | 4.3 | C[C@@H]1CN(c2cccc3cc(F)ccc23)CCN1CC[C@@H]1OCCc2cc(C(N)=O)ccc21 | 10.1016/j.bmcl.2007.03.101 | |||
| CHEMBL391271 | 145237 | 0 | None | -14 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 447 | 5 | 1 | 4 | 4.3 | C[C@@H]1CN(c2cccc3cc(F)ccc23)CCN1CC[C@@H]1OCCc2cc(C(N)=O)ccc21 | 10.1016/j.bmcl.2007.03.101 | |||
| 11297 | 67345 | 18 | None | -26 | 6 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2cccc(O)c12 | 10.1021/jm00384a001 | |||
| CHEMBL18855 | 67345 | 18 | None | -26 | 6 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2cccc(O)c12 | 10.1021/jm00384a001 | |||
| 44352308 | 117487 | 0 | None | -131 | 12 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 339 | 5 | 2 | 2 | 4.0 | Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C | 10.1021/jm0155190 | |||
| CHEMBL339980 | 117487 | 0 | None | -131 | 12 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 339 | 5 | 2 | 2 | 4.0 | Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C | 10.1021/jm0155190 | |||
| 44383729 | 59927 | 0 | None | -23 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 294 | 4 | 1 | 2 | 4.3 | C1=CCN(CCc2c[nH]c3ccc(-c4cccs4)cc23)C1 | 10.1016/s0960-894x(00)00133-5 | |||
| CHEMBL173162 | 59927 | 0 | None | -23 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 294 | 4 | 1 | 2 | 4.3 | C1=CCN(CCc2c[nH]c3ccc(-c4cccs4)cc23)C1 | 10.1016/s0960-894x(00)00133-5 | |||
| 4431 | 2729 | 25 | None | -3090 | 12 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 393 | 7 | 0 | 5 | 2.9 | COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 | 10.1021/jm00020a020 | |||
| 73 | 2729 | 25 | None | -3090 | 12 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 393 | 7 | 0 | 5 | 2.9 | COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 | 10.1021/jm00020a020 | |||
| CHEMBL8618 | 2729 | 25 | None | -3090 | 12 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 393 | 7 | 0 | 5 | 2.9 | COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 | 10.1021/jm00020a020 | |||
| 134 | 2514 | 24 | None | -251 | 67 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | nan | |||
| 1775 | 2514 | 24 | None | -251 | 67 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | nan | |||
| 9681 | 2514 | 24 | None | -251 | 67 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | nan | |||
| CHEMBL1065 | 2514 | 24 | None | -251 | 67 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | nan | |||
| DB00247 | 2514 | 24 | None | -251 | 67 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | nan | |||
| 10015980 | 204317 | 0 | None | -154 | 5 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 270 | 4 | 1 | 2 | 3.2 | CCCN(C)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL71469 | 204317 | 0 | None | -154 | 5 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 270 | 4 | 1 | 2 | 3.2 | CCCN(C)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| 10065919 | 103090 | 0 | None | -22 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 341 | 7 | 2 | 3 | 2.8 | CCCN(CCC)[C@H]1CCc2ccc3[nH]cc(C(=O)C(N)=O)c3c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL307521 | 103090 | 0 | None | -22 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 341 | 7 | 2 | 3 | 2.8 | CCCN(CCC)[C@H]1CCc2ccc3[nH]cc(C(=O)C(N)=O)c3c2C1 | 10.1021/jm00012a021 | |||
| 10250307 | 22607 | 0 | None | -295 | 2 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 398 | 5 | 0 | 4 | 4.4 | Clc1cccc2c1CC2CCCN1CCN(c2cccc3c2OCCO3)CC1 | 10.1021/jm00020a020 | |||
| CHEMBL132657 | 22607 | 0 | None | -295 | 2 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 398 | 5 | 0 | 4 | 4.4 | Clc1cccc2c1CC2CCCN1CCN(c2cccc3c2OCCO3)CC1 | 10.1021/jm00020a020 | |||
| 10896220 | 107530 | 0 | None | -3 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 486 | 6 | 1 | 5 | 4.4 | Cn1ccnc1-c1ccc2c(c1)c(C1CCN(CCN3CCNC3=O)CC1)cn2-c1ccc(F)cc1 | 10.1021/jm020938y | |||
| CHEMBL318735 | 107530 | 0 | None | -3 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 486 | 6 | 1 | 5 | 4.4 | Cn1ccnc1-c1ccc2c(c1)c(C1CCN(CCN3CCNC3=O)CC1)cn2-c1ccc(F)cc1 | 10.1021/jm020938y | |||
| 44337731 | 11379 | 0 | None | 21 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 442 | 5 | 0 | 5 | 3.1 | Cc1ccccc1N1CCN(C(=O)COc2ccc(Cl)c(N3CCN(C)CC3)c2)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL106807 | 11379 | 0 | None | 21 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 442 | 5 | 0 | 5 | 3.1 | Cc1ccccc1N1CCN(C(=O)COc2ccc(Cl)c(N3CCN(C)CC3)c2)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL1179968 | 11379 | 0 | None | 21 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 442 | 5 | 0 | 5 | 3.1 | Cc1ccccc1N1CCN(C(=O)COc2ccc(Cl)c(N3CCN(C)CC3)c2)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| 9862256 | 207120 | 0 | None | -7 | 9 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 328 | 5 | 0 | 4 | 3.0 | CN(C)CCc1cccc2c1ccn2S(=O)(=O)c1ccccc1 | 10.1021/jm010943m | |||
| CHEMBL92139 | 207120 | 0 | None | -7 | 9 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 328 | 5 | 0 | 4 | 3.0 | CN(C)CCc1cccc2c1ccn2S(=O)(=O)c1ccccc1 | 10.1021/jm010943m | |||
| 44342823 | 113809 | 0 | None | -2 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 472 | 4 | 2 | 2 | 5.6 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(C(=O)NC45C[C@H]6C[C@@H](C4)C[C@@H](C5)C6)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
| CHEMBL332484 | 113809 | 0 | None | -2 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 472 | 4 | 2 | 2 | 5.6 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(C(=O)NC45C[C@H]6C[C@@H](C4)C[C@@H](C5)C6)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
| 133 | 2496 | 52 | None | -40 | 42 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | |||
| 1723 | 2496 | 52 | None | -40 | 42 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | |||
| 28693 | 2496 | 52 | None | -40 | 42 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | |||
| CHEMBL19215 | 2496 | 52 | None | -40 | 42 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | |||
| DB13520 | 2496 | 52 | None | -40 | 42 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | |||
| 107715 | 200945 | 22 | None | -22 | 19 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 611 | 5 | 3 | 6 | 2.7 | CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O | nan | |||
| CHEMBL1255837 | 200945 | 22 | None | -22 | 19 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 611 | 5 | 3 | 6 | 2.7 | CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O | nan | |||
| CHEMBL601773 | 200945 | 22 | None | -22 | 19 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 611 | 5 | 3 | 6 | 2.7 | CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O | nan | |||
| 10069802 | 102878 | 0 | None | -9 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 404 | 9 | 1 | 3 | 5.2 | CCCN(CCCc1ccccc1OC)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL305837 | 102878 | 0 | None | -9 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 404 | 9 | 1 | 3 | 5.2 | CCCN(CCCc1ccccc1OC)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| 10044965 | 204168 | 0 | None | -18 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 374 | 8 | 1 | 2 | 5.2 | CCCN(CCCc1ccccc1)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL70680 | 204168 | 0 | None | -18 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 374 | 8 | 1 | 2 | 5.2 | CCCN(CCCc1ccccc1)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| 59636718 | 126226 | 0 | None | - | 1 | Chinese hamster | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 456 | 5 | 0 | 5 | 3.7 | CN(C)C(=O)c1cc2c(Br)ccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| CHEMBL3650046 | 126226 | 0 | None | - | 1 | Chinese hamster | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 456 | 5 | 0 | 5 | 3.7 | CN(C)C(=O)c1cc2c(Br)ccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| 44404394 | 132815 | 0 | None | 3 | 7 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 443 | 4 | 1 | 5 | 3.5 | COc1ccc(NC(=O)N2CCN(c3ccccc3Cl)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
| CHEMBL370128 | 132815 | 0 | None | 3 | 7 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 443 | 4 | 1 | 5 | 3.5 | COc1ccc(NC(=O)N2CCN(c3ccccc3Cl)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
| 415628 | 208192 | 95 | None | 2 | 5 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 196 | 1 | 1 | 2 | 1.8 | Clc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
| CHEMBL9841 | 208192 | 95 | None | 2 | 5 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 196 | 1 | 1 | 2 | 1.8 | Clc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
| 11049209 | 207405 | 0 | None | -223 | 8 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 486 | 6 | 1 | 5 | 4.4 | Cn1ccc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | |||
| CHEMBL93923 | 207405 | 0 | None | -223 | 8 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 486 | 6 | 1 | 5 | 4.4 | Cn1ccc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | |||
| 44376492 | 119986 | 0 | None | -11 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 469 | 6 | 1 | 3 | 4.9 | O=S(=O)(c1ccc(Cl)cc1)N1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1 | 10.1016/j.bmcl.2003.11.023 | |||
| CHEMBL349903 | 119986 | 0 | None | -11 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 469 | 6 | 1 | 3 | 4.9 | O=S(=O)(c1ccc(Cl)cc1)N1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1 | 10.1016/j.bmcl.2003.11.023 | |||
| 10198756 | 4870 | 1 | None | -4 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 245 | 2 | 1 | 3 | 2.4 | COc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| CHEMBL104374 | 4870 | 1 | None | -4 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 245 | 2 | 1 | 3 | 2.4 | COc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| 10925382 | 5016 | 0 | None | -85 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 324 | 3 | 2 | 4 | 3.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccco4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL105091 | 5016 | 0 | None | -85 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 324 | 3 | 2 | 4 | 3.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccco4)nc23)CC1 | 10.1021/jm030020m | |||
| 6422277 | 30036 | 5 | None | -28 | 4 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 271 | 8 | 0 | 2 | 4.3 | CCCCN(CC)CCOc1cccc2ccccc12 | 10.1021/jm00124a021 | |||
| CHEMBL138907 | 30036 | 5 | None | -28 | 4 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 271 | 8 | 0 | 2 | 4.3 | CCCCN(CC)CCOc1cccc2ccccc12 | 10.1021/jm00124a021 | |||
| 44383738 | 60266 | 0 | None | -13 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 326 | 5 | 2 | 3 | 3.9 | OC[C@@H]1CCCN1CCc1c[nH]c2ccc(-c3cccs3)cc12 | 10.1016/s0960-894x(00)00133-5 | |||
| CHEMBL174141 | 60266 | 0 | None | -13 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 326 | 5 | 2 | 3 | 3.9 | OC[C@@H]1CCCN1CCc1c[nH]c2ccc(-c3cccs3)cc12 | 10.1016/s0960-894x(00)00133-5 | |||
| 122197403 | 133474 | 0 | None | -8 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 433 | 5 | 1 | 4 | 4.3 | C[C@H]1CN(c2cccc3cc(F)ccc23)CCN1CC[C@@H]1OCc2cc(C(N)=O)ccc21 | 10.1016/j.bmcl.2007.03.101 | |||
| CHEMBL3706923 | 133474 | 0 | None | -8 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 433 | 5 | 1 | 4 | 4.3 | C[C@H]1CN(c2cccc3cc(F)ccc23)CCN1CC[C@@H]1OCc2cc(C(N)=O)ccc21 | 10.1016/j.bmcl.2007.03.101 | |||
| 9981270 | 165274 | 0 | None | -40 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 451 | 9 | 1 | 4 | 4.5 | CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL423127 | 165274 | 0 | None | -40 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 451 | 9 | 1 | 4 | 4.5 | CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| 115 | 3791 | 80 | None | 1 | 27 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 10.1021/jm00145a017 | |||
| 4296 | 3791 | 80 | None | 1 | 27 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 10.1021/jm00145a017 | |||
| CHEMBL274866 | 3791 | 80 | None | 1 | 27 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 10.1021/jm00145a017 | |||
| 11662592 | 72344 | 0 | None | -97 | 9 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccnc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
| CHEMBL198463 | 72344 | 0 | None | -97 | 9 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5ccnc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
| 44292367 | 101869 | 0 | None | -33 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 228 | 2 | 1 | 1 | 3.1 | Cc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1 | 10.1016/s0960-894x(00)00322-x | |||
| CHEMBL300686 | 101869 | 0 | None | -33 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 228 | 2 | 1 | 1 | 3.1 | Cc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1 | 10.1016/s0960-894x(00)00322-x | |||
| 10003971 | 63033 | 0 | None | -199 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 451 | 9 | 1 | 4 | 4.5 | CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL1788198 | 63033 | 0 | None | -199 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 451 | 9 | 1 | 4 | 4.5 | CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL5083607 | 214873 | 0 | None | 1 | 9 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | None | None | None | COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||||
| 25067561 | 201092 | 4 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 466 | 5 | 1 | 7 | 2.6 | COc1cc2c(c(N3CCN(C)CC3)c1)O[C@@H](C(=O)Nc1ccc(N3CCOCC3)cc1)CC2 | 10.1021/jm901200t | |||
| CHEMBL602875 | 201092 | 4 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 466 | 5 | 1 | 7 | 2.6 | COc1cc2c(c(N3CCN(C)CC3)c1)O[C@@H](C(=O)Nc1ccc(N3CCOCC3)cc1)CC2 | 10.1021/jm901200t | |||
| 44394222 | 127554 | 0 | None | -39 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 245 | 1 | 2 | 3 | 3.0 | Cc1cc(C(C)(C)C)cc(C)c1NC1=NCCN1 | 10.1016/j.bmcl.2004.06.085 | |||
| CHEMBL366322 | 127554 | 0 | None | -39 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 245 | 1 | 2 | 3 | 3.0 | Cc1cc(C(C)(C)C)cc(C)c1NC1=NCCN1 | 10.1016/j.bmcl.2004.06.085 | |||
| 113 | 1852 | 14 | None | 39 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 375 | 7 | 2 | 4 | 4.2 | CN(CCCc1cc(ccc1O)C(=O)Nc1ccc(cc1)c1ccncc1)C | 10.1021/jm9702948 | |||
| 128018 | 1852 | 14 | None | 39 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 375 | 7 | 2 | 4 | 4.2 | CN(CCCc1cc(ccc1O)C(=O)Nc1ccc(cc1)c1ccncc1)C | 10.1021/jm9702948 | |||
| CHEMBL119264 | 1852 | 14 | None | 39 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 375 | 7 | 2 | 4 | 4.2 | CN(CCCc1cc(ccc1O)C(=O)Nc1ccc(cc1)c1ccncc1)C | 10.1021/jm9702948 | |||
| 25067561 | 201092 | 4 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 466 | 5 | 1 | 7 | 2.6 | COc1cc2c(c(N3CCN(C)CC3)c1)O[C@@H](C(=O)Nc1ccc(N3CCOCC3)cc1)CC2 | 10.1021/jm901200t | |||
| CHEMBL602875 | 201092 | 4 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 466 | 5 | 1 | 7 | 2.6 | COc1cc2c(c(N3CCN(C)CC3)c1)O[C@@H](C(=O)Nc1ccc(N3CCOCC3)cc1)CC2 | 10.1021/jm901200t | |||
| 10478367 | 71670 | 0 | None | 19 | 7 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 439 | 5 | 1 | 6 | 2.8 | COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
| CHEMBL196370 | 71670 | 0 | None | 19 | 7 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 439 | 5 | 1 | 6 | 2.8 | COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
| CHEMBL430500 | 71670 | 0 | None | 19 | 7 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 439 | 5 | 1 | 6 | 2.8 | COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
| 44402874 | 133546 | 0 | None | 19 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 447 | 3 | 0 | 4 | 4.7 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)c1cccc(Cl)c1Cl)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| CHEMBL370896 | 133546 | 0 | None | 19 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 447 | 3 | 0 | 4 | 4.7 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)c1cccc(Cl)c1Cl)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| 44444556 | 94402 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 471 | 6 | 0 | 5 | 4.4 | CCOc1ccc(CC(=O)N2CCc3cc(OC)c(N4C[C@H](C)N(C)[C@H](C)C4)cc32)cc1Cl | 10.1016/j.bmcl.2007.09.067 | |||
| CHEMBL250973 | 94402 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 471 | 6 | 0 | 5 | 4.4 | CCOc1ccc(CC(=O)N2CCc3cc(OC)c(N4C[C@H](C)N(C)[C@H](C)C4)cc32)cc1Cl | 10.1016/j.bmcl.2007.09.067 | |||
| 10436045 | 3516 | 4 | None | -3 | 13 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(01)00397-3 | |||
| 782 | 3516 | 4 | None | -3 | 13 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(01)00397-3 | |||
| CHEMBL432713 | 3516 | 4 | None | -3 | 13 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(01)00397-3 | |||
| 10597210 | 77131 | 0 | None | 3 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 401 | 3 | 1 | 3 | 4.1 | Cc1cc(C(=O)Nc2ccc(C)c(N3CCN(C)CC3)c2)ccc1Br | 10.1021/jm970457s | |||
| CHEMBL20771 | 77131 | 0 | None | 3 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 401 | 3 | 1 | 3 | 4.1 | Cc1cc(C(=O)Nc2ccc(C)c(N3CCN(C)CC3)c2)ccc1Br | 10.1021/jm970457s | |||
| 49850768 | 56393 | 0 | None | -39 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 402 | 5 | 0 | 4 | 3.9 | CC(=O)N(C)c1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
| CHEMBL1631539 | 56393 | 0 | None | -39 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 402 | 5 | 0 | 4 | 3.9 | CC(=O)N(C)c1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
| 10310285 | 189925 | 0 | None | -6 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 437 | 7 | 0 | 4 | 5.9 | Cc1ccc2c(OCCN3CCC(Cc4cccc(-c5cccnc5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| CHEMBL516997 | 189925 | 0 | None | -6 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 437 | 7 | 0 | 4 | 5.9 | Cc1ccc2c(OCCN3CCC(Cc4cccc(-c5cccnc5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| 24865726 | 187656 | 0 | None | -7 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 467 | 8 | 0 | 5 | 4.3 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N(C)S(C)(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
| CHEMBL495046 | 187656 | 0 | None | -7 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 467 | 8 | 0 | 5 | 4.3 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N(C)S(C)(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
| 24865727 | 193113 | 0 | None | -7 | 11 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 479 | 7 | 0 | 5 | 4.4 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCS5(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
| CHEMBL522708 | 193113 | 0 | None | -7 | 11 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 479 | 7 | 0 | 5 | 4.4 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCS5(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
| 56935645 | 67917 | 0 | None | -2 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 553 | 5 | 1 | 6 | 5.1 | COc1ccc(NC(=O)c2ccc3c(c2)N(C)C(=O)CN3c2ccc(Cl)c(Cl)c2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2011.09.046 | |||
| CHEMBL1910792 | 67917 | 0 | None | -2 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 553 | 5 | 1 | 6 | 5.1 | COc1ccc(NC(=O)c2ccc3c(c2)N(C)C(=O)CN3c2ccc(Cl)c(Cl)c2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2011.09.046 | |||
| 14083218 | 63051 | 7 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 190 | 2 | 3 | 2 | 1.8 | C[C@@H](N)Cc1c[nH]c2ccc(O)cc12 | 10.1021/jm00402a026 | |||
| CHEMBL1788239 | 63051 | 7 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 190 | 2 | 3 | 2 | 1.8 | C[C@@H](N)Cc1c[nH]c2ccc(O)cc12 | 10.1021/jm00402a026 | |||
| 92042876 | 151336 | 0 | None | -229 | 10 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 261 | 4 | 1 | 2 | 3.7 | CNCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||
| CHEMBL3961059 | 151336 | 0 | None | -229 | 10 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 261 | 4 | 1 | 2 | 3.7 | CNCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||
| 10020895 | 4705 | 0 | None | -158 | 8 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL103479 | 4705 | 0 | None | -158 | 8 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| 10926112 | 172631 | 0 | None | -208 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 348 | 3 | 2 | 3 | 3.9 | Cc1cccc(C(=O)Nc2ccc3[nH]cc(C4CCN(C)CC4)c3n2)c1 | 10.1021/jm030020m | |||
| CHEMBL449406 | 172631 | 0 | None | -208 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 348 | 3 | 2 | 3 | 3.9 | Cc1cccc(C(=O)Nc2ccc3[nH]cc(C4CCN(C)CC4)c3n2)c1 | 10.1021/jm030020m | |||
| 2274 | 3173 | 58 | None | -39 | 31 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | |||
| 4917 | 3173 | 58 | None | -39 | 31 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | |||
| 7279 | 3173 | 58 | None | -39 | 31 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | |||
| CHEMBL728 | 3173 | 58 | None | -39 | 31 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | |||
| DB00433 | 3173 | 58 | None | -39 | 31 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | |||
| 145990586 | 166843 | 0 | None | -93 | 11 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 297 | 2 | 2 | 4 | 2.6 | COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2 | 10.1039/C7MD00656J | |||
| CHEMBL4285281 | 166843 | 0 | None | -93 | 11 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 297 | 2 | 2 | 4 | 2.6 | COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2 | 10.1039/C7MD00656J | |||
| 10358224 | 204320 | 0 | None | -52 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 313 | 5 | 1 | 2 | 4.2 | CCCN(CCC)C1CCc2cc(F)c3[nH]cc(C#N)c3c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL71474 | 204320 | 0 | None | -52 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 313 | 5 | 1 | 2 | 4.2 | CCCN(CCC)C1CCc2cc(F)c3[nH]cc(C#N)c3c2C1 | 10.1021/jm00012a021 | |||
| 53248361 | 62082 | 0 | None | -77 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 568 | 7 | 0 | 5 | 3.2 | COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52I)c2ccccn2)CC1 | 10.1021/jm1009956 | |||
| CHEMBL1774991 | 62082 | 0 | None | -77 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 568 | 7 | 0 | 5 | 3.2 | COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52I)c2ccccn2)CC1 | 10.1021/jm1009956 | |||
| 73213196 | 104460 | 4 | None | -11 | 13 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 288 | 0 | 0 | 2 | 3.9 | CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
| CHEMBL3104093 | 104460 | 4 | None | -11 | 13 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 288 | 0 | 0 | 2 | 3.9 | CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
| 73213196 | 104460 | 4 | None | -11 | 13 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 288 | 0 | 0 | 2 | 3.9 | CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
| CHEMBL3104093 | 104460 | 4 | None | -11 | 13 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 288 | 0 | 0 | 2 | 3.9 | CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
| 2812 | 4779 | 101 | None | -51 | 34 | Rat | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | |||
| CHEMBL104 | 4779 | 101 | None | -51 | 34 | Rat | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | |||
| 62597539 | 106212 | 2 | None | -1 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 307 | 4 | 1 | 2 | 2.8 | CNCCOc1ccc(Br)cc1Br | 10.1007/s00044-009-9164-1 | |||
| CHEMBL2260923 | 106212 | 2 | None | -1 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 307 | 4 | 1 | 2 | 2.8 | CNCCOc1ccc(Br)cc1Br | 10.1007/s00044-009-9164-1 | |||
| CHEMBL3138772 | 106212 | 2 | None | -1 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 307 | 4 | 1 | 2 | 2.8 | CNCCOc1ccc(Br)cc1Br | 10.1007/s00044-009-9164-1 | |||
| 11794624 | 80212 | 1 | None | 1 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 387 | 3 | 1 | 3 | 3.8 | Cc1cc(C(=O)Nc2cccc(N3CCN(C)CC3)c2)ccc1Br | 10.1021/jm970457s | |||
| CHEMBL21369 | 80212 | 1 | None | 1 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 387 | 3 | 1 | 3 | 3.8 | Cc1cc(C(=O)Nc2cccc(N3CCN(C)CC3)c2)ccc1Br | 10.1021/jm970457s | |||
| 10310423 | 175496 | 0 | None | -50 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 445 | 7 | 0 | 5 | 4.7 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCOCC5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| CHEMBL457765 | 175496 | 0 | None | -50 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 445 | 7 | 0 | 5 | 4.7 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCOCC5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| 10238763 | 175694 | 0 | None | -15 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 472 | 7 | 0 | 5 | 4.2 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCN(C)C(=O)C5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| CHEMBL458200 | 175694 | 0 | None | -15 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 472 | 7 | 0 | 5 | 4.2 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCN(C)C(=O)C5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| 44580784 | 188086 | 0 | None | -501 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 420 | 4 | 1 | 5 | 3.4 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)ccc(F)c2n1 | 10.1016/j.bmcl.2008.08.084 | |||
| CHEMBL497979 | 188086 | 0 | None | -501 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 420 | 4 | 1 | 5 | 3.4 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)ccc(F)c2n1 | 10.1016/j.bmcl.2008.08.084 | |||
| 9891617 | 207982 | 0 | None | -1000 | 5 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 486 | 4 | 2 | 6 | 4.9 | Cc1cc(N2CCNCC2)c2cc(NS(=O)(=O)c3sc4ccc(Cl)cc4c3C)ccc2n1 | 10.1016/s0960-894x(01)00558-3 | |||
| CHEMBL97211 | 207982 | 0 | None | -1000 | 5 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 486 | 4 | 2 | 6 | 4.9 | Cc1cc(N2CCNCC2)c2cc(NS(=O)(=O)c3sc4ccc(Cl)cc4c3C)ccc2n1 | 10.1016/s0960-894x(01)00558-3 | |||
| 10413595 | 161841 | 0 | None | -3981 | 11 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 499 | 4 | 1 | 5 | 2.5 | COc1ccc(S(=O)(=O)N2CCc3ccc(I)cc32)cc1N1CCNCC1 | 10.1016/s0960-894x(00)00597-7 | |||
| CHEMBL414628 | 161841 | 0 | None | -3981 | 11 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 499 | 4 | 1 | 5 | 2.5 | COc1ccc(S(=O)(=O)N2CCc3ccc(I)cc32)cc1N1CCNCC1 | 10.1016/s0960-894x(00)00597-7 | |||
| 10115848 | 90770 | 0 | None | -794 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 465 | 6 | 1 | 5 | 4.9 | Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
| CHEMBL239166 | 90770 | 0 | None | -794 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 465 | 6 | 1 | 5 | 4.9 | Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
| 24865540 | 187676 | 0 | None | -7 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 418 | 7 | 1 | 5 | 3.7 | CC(=O)Nc1ccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)cc1 | 10.1021/jm8001444 | |||
| CHEMBL495160 | 187676 | 0 | None | -7 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 418 | 7 | 1 | 5 | 3.7 | CC(=O)Nc1ccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)cc1 | 10.1021/jm8001444 | |||
| 24881618 | 188787 | 0 | None | -125 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 798 | 16 | 4 | 4 | 11.2 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | 10.1021/jm7011722 | |||
| CHEMBL505750 | 188787 | 0 | None | -125 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 798 | 16 | 4 | 4 | 11.2 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | 10.1021/jm7011722 | |||
| 24881619 | 189038 | 0 | None | -9 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 826 | 18 | 4 | 4 | 12.0 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | 10.1021/jm7011722 | |||
| CHEMBL509314 | 189038 | 0 | None | -9 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 826 | 18 | 4 | 4 | 12.0 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | 10.1021/jm7011722 | |||
| 277 | 1301 | 62 | None | -501 | 50 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | |||
| 2913 | 1301 | 62 | None | -501 | 50 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | |||
| 765 | 1301 | 62 | None | -501 | 50 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | |||
| CHEMBL516 | 1301 | 62 | None | -501 | 50 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | |||
| DB00434 | 1301 | 62 | None | -501 | 50 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | |||
| 50878551 | 90745 | 61 | None | -7 | 18 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 270 | 8 | 1 | 2 | 3.4 | C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 | 10.1016/j.bmcl.2013.03.066 | |||
| CHEMBL2391541 | 90745 | 61 | None | -7 | 18 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 270 | 8 | 1 | 2 | 3.4 | C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 | 10.1016/j.bmcl.2013.03.066 | |||
| 50878551 | 90745 | 61 | None | -7 | 18 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 270 | 8 | 1 | 2 | 3.4 | C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 | 10.1016/j.bmcl.2013.03.066 | |||
| CHEMBL2391541 | 90745 | 61 | None | -7 | 18 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 270 | 8 | 1 | 2 | 3.4 | C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 | 10.1016/j.bmcl.2013.03.066 | |||
| 44342783 | 9819 | 0 | None | -6 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 436 | 4 | 2 | 2 | 5.5 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(/C(S)=N/C4CCCCC4)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
| CHEMBL113868 | 9819 | 0 | None | -6 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 436 | 4 | 2 | 2 | 5.5 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(/C(S)=N/C4CCCCC4)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
| 3658 | 4107 | 53 | None | -4 | 8 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 244 | 2 | 1 | 2 | 3.1 | Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C | 10.1016/j.bmcl.2004.06.085 | |||
| 517 | 4107 | 53 | None | -4 | 8 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 244 | 2 | 1 | 2 | 3.1 | Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C | 10.1016/j.bmcl.2004.06.085 | |||
| 5709 | 4107 | 53 | None | -4 | 8 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 244 | 2 | 1 | 2 | 3.1 | Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C | 10.1016/j.bmcl.2004.06.085 | |||
| CHEMBL312448 | 4107 | 53 | None | -4 | 8 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 244 | 2 | 1 | 2 | 3.1 | Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C | 10.1016/j.bmcl.2004.06.085 | |||
| DB06694 | 4107 | 53 | None | -4 | 8 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 244 | 2 | 1 | 2 | 3.1 | Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C | 10.1016/j.bmcl.2004.06.085 | |||
| 106 | 148 | 26 | None | -4 | 6 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 302 | 11 | 2 | 2 | 4.8 | CCCCCCCCCOc1ccc2c(c1)c(CCN)c[nH]2 | 10.1021/jm00044a001 | |||
| 1797 | 148 | 26 | None | -4 | 6 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 302 | 11 | 2 | 2 | 4.8 | CCCCCCCCCOc1ccc2c(c1)c(CCN)c[nH]2 | 10.1021/jm00044a001 | |||
| CHEMBL97450 | 148 | 26 | None | -4 | 6 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 302 | 11 | 2 | 2 | 4.8 | CCCCCCCCCOc1ccc2c(c1)c(CCN)c[nH]2 | 10.1021/jm00044a001 | |||
| 52942395 | 17921 | 0 | None | -24 | 5 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 386 | 3 | 0 | 4 | 5.0 | CN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4cncnc4)cc23)CC1 | 10.1016/j.bmc.2012.10.049 | |||
| CHEMBL1259203 | 17921 | 0 | None | -24 | 5 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 386 | 3 | 0 | 4 | 5.0 | CN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4cncnc4)cc23)CC1 | 10.1016/j.bmc.2012.10.049 | |||
| 10643939 | 14111 | 0 | None | 35 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 387 | 7 | 1 | 4 | 4.6 | COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1/C=C/CN(C)C | 10.1021/jm9702948 | |||
| CHEMBL119800 | 14111 | 0 | None | 35 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 387 | 7 | 1 | 4 | 4.6 | COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1/C=C/CN(C)C | 10.1021/jm9702948 | |||
| 44403101 | 71997 | 0 | None | -2 | 6 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 485 | 5 | 1 | 5 | 4.5 | COc1ccc(NC(=O)N2CCN(c3ccc(-c4ccccc4)cc3)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
| CHEMBL197408 | 71997 | 0 | None | -2 | 6 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 485 | 5 | 1 | 5 | 4.5 | COc1ccc(NC(=O)N2CCN(c3ccc(-c4ccccc4)cc3)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
| 83357 | 98172 | 69 | None | -1 | 3 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 206 | 3 | 1 | 3 | 1.5 | CCOc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
| CHEMBL273923 | 98172 | 69 | None | -1 | 3 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 206 | 3 | 1 | 3 | 1.5 | CCOc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
| 44376494 | 56262 | 0 | None | -4 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 420 | 6 | 2 | 3 | 4.5 | O=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)C1CCCCC1 | 10.1016/j.bmcl.2003.11.023 | |||
| CHEMBL162771 | 56262 | 0 | None | -4 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 420 | 6 | 2 | 3 | 4.5 | O=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)C1CCCCC1 | 10.1016/j.bmcl.2003.11.023 | |||
| 10163458 | 85182 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 490 | 6 | 2 | 8 | 3.1 | CNc1cc(C(=O)Nc2ccc(N3CCOCC3)cc2)nc2c(N3CCN(C)CC3)cc(OC)cc12 | 10.1016/j.bmc.2006.10.037 | |||
| CHEMBL225364 | 85182 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 490 | 6 | 2 | 8 | 3.1 | CNc1cc(C(=O)Nc2ccc(N3CCOCC3)cc2)nc2c(N3CCN(C)CC3)cc(OC)cc12 | 10.1016/j.bmc.2006.10.037 | |||
| 10089261 | 102474 | 0 | None | - | 1 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 350 | 4 | 0 | 4 | 4.5 | CN(C)CCSc1nc2ccccc2c2c1CCOc1ccccc1-2 | 10.1021/jm00014a021 | |||
| CHEMBL304016 | 102474 | 0 | None | - | 1 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 350 | 4 | 0 | 4 | 4.5 | CN(C)CCSc1nc2ccccc2c2c1CCOc1ccccc1-2 | 10.1021/jm00014a021 | |||
| 206 | 2493 | 16 | None | -7585 | 25 | Rat | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | 10.1021/jm00384a001 | |||
| 68848 | 2493 | 16 | None | -7585 | 25 | Rat | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | 10.1021/jm00384a001 | |||
| CHEMBL12314 | 2493 | 16 | None | -7585 | 25 | Rat | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | 10.1021/jm00384a001 | |||
| 72550642 | 114078 | 0 | None | -15 | 8 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 491 | 10 | 1 | 4 | 5.6 | COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1 | 10.1016/j.bmc.2014.07.026 | |||
| CHEMBL3326982 | 114078 | 0 | None | -15 | 8 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 491 | 10 | 1 | 4 | 5.6 | COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1 | 10.1016/j.bmc.2014.07.026 | |||
| 44461249 | 205351 | 0 | None | -15 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 421 | 5 | 2 | 3 | 4.3 | NC(=O)c1ccc2c(c1)CCOC2CCN1CCC(c2c[nH]c3cc(F)ccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
| CHEMBL79674 | 205351 | 0 | None | -15 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 421 | 5 | 2 | 3 | 4.3 | NC(=O)c1ccc2c(c1)CCOC2CCN1CCC(c2c[nH]c3cc(F)ccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
| 44269026 | 33744 | 0 | None | -363 | 2 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 458 | 6 | 0 | 4 | 3.7 | COc1cccc2c1C1CCN(CCCCN3C(=O)C4C5C=CC(C6C=CC65)C4C3=O)CC1C2 | 10.1021/jm00027a013 | |||
| CHEMBL14224 | 33744 | 0 | None | -363 | 2 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 458 | 6 | 0 | 4 | 3.7 | COc1cccc2c1C1CCN(CCCCN3C(=O)C4C5C=CC(C6C=CC65)C4C3=O)CC1C2 | 10.1021/jm00027a013 | |||
| CHEMBL1743629 | 33744 | 0 | None | -363 | 2 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 458 | 6 | 0 | 4 | 3.7 | COc1cccc2c1C1CCN(CCCCN3C(=O)C4C5C=CC(C6C=CC65)C4C3=O)CC1C2 | 10.1021/jm00027a013 | |||
| 10016747 | 60298 | 0 | None | -40 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 284 | 4 | 1 | 2 | 4.3 | Cc1ccc(-c2ccc3[nH]cc(CCN(C)C)c3c2)s1 | 10.1016/s0960-894x(00)00133-5 | |||
| CHEMBL174355 | 60298 | 0 | None | -40 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 284 | 4 | 1 | 2 | 4.3 | Cc1ccc(-c2ccc3[nH]cc(CCN(C)C)c3c2)s1 | 10.1016/s0960-894x(00)00133-5 | |||
| 127036186 | 137414 | 0 | None | -42 | 19 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 254 | 7 | 1 | 1 | 3.7 | C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12 | 10.1016/j.bmcl.2015.12.053 | |||
| CHEMBL3753318 | 137414 | 0 | None | -42 | 19 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 254 | 7 | 1 | 1 | 3.7 | C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12 | 10.1016/j.bmcl.2015.12.053 | |||
| 21509921 | 104458 | 0 | None | -131 | 24 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 288 | 0 | 0 | 2 | 3.7 | CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
| CHEMBL3104091 | 104458 | 0 | None | -131 | 24 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 288 | 0 | 0 | 2 | 3.7 | CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
| 10498633 | 163303 | 0 | None | 1 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 358 | 15 | 2 | 2 | 6.2 | CCCCCCCCCOc1ccc2[nH]cc(CCNCCCC)c2c1 | 10.1021/jm950498t | |||
| CHEMBL418823 | 163303 | 0 | None | 1 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 358 | 15 | 2 | 2 | 6.2 | CCCCCCCCCOc1ccc2[nH]cc(CCNCCCC)c2c1 | 10.1021/jm950498t | |||
| CHEMBL1200558 | 208599 | 21 | None | - | 1 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](N)C1=N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H]2CCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H](CCCN)NC2=O)[C@@H](C)CC)CS1 | nan | |||||
| 125957 | 120160 | 8 | None | -1 | 2 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 256 | 0 | 1 | 2 | 2.4 | FC(F)(F)c1ccc2c(c1)N1CCNCC1CC2 | 10.1021/jm00145a017 | |||
| CHEMBL351530 | 120160 | 8 | None | -1 | 2 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 256 | 0 | 1 | 2 | 2.4 | FC(F)(F)c1ccc2c(c1)N1CCNCC1CC2 | 10.1021/jm00145a017 | |||
| 14975319 | 77234 | 0 | None | -245 | 2 | Rat | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 424 | 6 | 0 | 4 | 4.1 | COc1cccc2c1[C@@H]1CCN(CCCCN3C(=O)CC4(CCCC4)CC3=O)C[C@@H]1C2 | 10.1021/jm00027a013 | |||
| CHEMBL2079545 | 77234 | 0 | None | -245 | 2 | Rat | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 424 | 6 | 0 | 4 | 4.1 | COc1cccc2c1[C@@H]1CCN(CCCCN3C(=O)CC4(CCCC4)CC3=O)C[C@@H]1C2 | 10.1021/jm00027a013 | |||
| 21509921 | 104458 | 0 | None | -131 | 24 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 288 | 0 | 0 | 2 | 3.7 | CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
| CHEMBL3104091 | 104458 | 0 | None | -131 | 24 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 288 | 0 | 0 | 2 | 3.7 | CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
| 6761 | 67799 | 19 | None | -43 | 18 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 401 | 5 | 1 | 4 | 4.5 | NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 | nan | |||
| CHEMBL1909072 | 67799 | 19 | None | -43 | 18 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 401 | 5 | 1 | 4 | 4.5 | NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 | nan | |||
| 117209962 | 184869 | 1 | None | -52 | 7 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 242 | 2 | 2 | 3 | 1.8 | Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
| CHEMBL4852622 | 184869 | 1 | None | -52 | 7 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 242 | 2 | 2 | 3 | 1.8 | Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
| 448779 | 63068 | 35 | None | - | 1 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 174 | 2 | 2 | 1 | 2.1 | C[C@@H](N)Cc1c[nH]c2ccccc12 | 10.1021/jm00402a026 | |||
| CHEMBL1788285 | 63068 | 35 | None | - | 1 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 174 | 2 | 2 | 1 | 2.1 | C[C@@H](N)Cc1c[nH]c2ccccc12 | 10.1021/jm00402a026 | |||
| 10858566 | 102087 | 1 | None | -22 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 270 | 5 | 1 | 1 | 4.1 | CCCN(CCC)[C@@H]1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL302172 | 102087 | 1 | None | -22 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 270 | 5 | 1 | 1 | 4.1 | CCCN(CCC)[C@@H]1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a021 | |||
| 10858566 | 102087 | 1 | None | -22 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 270 | 5 | 1 | 1 | 4.1 | CCCN(CCC)[C@@H]1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL302172 | 102087 | 1 | None | -22 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 270 | 5 | 1 | 1 | 4.1 | CCCN(CCC)[C@@H]1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
| 11826976 | 207528 | 1 | None | -1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 483 | 6 | 1 | 4 | 5.0 | O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4cccnc4)cc23)CC1 | 10.1021/jm020938y | |||
| CHEMBL94612 | 207528 | 1 | None | -1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 483 | 6 | 1 | 4 | 5.0 | O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4cccnc4)cc23)CC1 | 10.1021/jm020938y | |||
| 113 | 1852 | 14 | None | 39 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 375 | 7 | 2 | 4 | 4.2 | CN(CCCc1cc(ccc1O)C(=O)Nc1ccc(cc1)c1ccncc1)C | 10.1021/jm9702948 | |||
| 128018 | 1852 | 14 | None | 39 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 375 | 7 | 2 | 4 | 4.2 | CN(CCCc1cc(ccc1O)C(=O)Nc1ccc(cc1)c1ccncc1)C | 10.1021/jm9702948 | |||
| CHEMBL119264 | 1852 | 14 | None | 39 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 375 | 7 | 2 | 4 | 4.2 | CN(CCCc1cc(ccc1O)C(=O)Nc1ccc(cc1)c1ccncc1)C | 10.1021/jm9702948 | |||
| 44342727 | 10171 | 0 | None | -18 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 465 | 6 | 1 | 4 | 4.3 | COc1ccc(S(=O)(=O)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1 | 10.1016/s0960-894x(03)00779-0 | |||
| CHEMBL115941 | 10171 | 0 | None | -18 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 465 | 6 | 1 | 4 | 4.3 | COc1ccc(S(=O)(=O)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1 | 10.1016/s0960-894x(03)00779-0 | |||
| 44342705 | 110114 | 0 | None | -4 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 420 | 4 | 2 | 2 | 4.9 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(C(=O)NC4CCCCC4)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
| CHEMBL323603 | 110114 | 0 | None | -4 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 420 | 4 | 2 | 2 | 4.9 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(C(=O)NC4CCCCC4)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
| 3658 | 4107 | 53 | None | -4 | 8 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 244 | 2 | 1 | 2 | 3.1 | Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C | 10.1021/jm970513p | |||
| 517 | 4107 | 53 | None | -4 | 8 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 244 | 2 | 1 | 2 | 3.1 | Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C | 10.1021/jm970513p | |||
| 5709 | 4107 | 53 | None | -4 | 8 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 244 | 2 | 1 | 2 | 3.1 | Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C | 10.1021/jm970513p | |||
| CHEMBL312448 | 4107 | 53 | None | -4 | 8 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 244 | 2 | 1 | 2 | 3.1 | Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C | 10.1021/jm970513p | |||
| DB06694 | 4107 | 53 | None | -4 | 8 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 244 | 2 | 1 | 2 | 3.1 | Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C | 10.1021/jm970513p | |||
| 10518850 | 35193 | 0 | None | -2 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 308 | 4 | 2 | 4 | 1.9 | NCCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
| CHEMBL143512 | 35193 | 0 | None | -2 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 308 | 4 | 2 | 4 | 1.9 | NCCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
| 5 | 139 | 72 | None | -11 | 54 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm2006782 | |||
| 5202 | 139 | 72 | None | -11 | 54 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm2006782 | |||
| CHEMBL39 | 139 | 72 | None | -11 | 54 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm2006782 | |||
| DB08839 | 139 | 72 | None | -11 | 54 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm2006782 | |||
| 10828231 | 9354 | 2 | None | 2 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 302 | 10 | 2 | 2 | 4.7 | CC(C)CCCCCCOc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
| CHEMBL111283 | 9354 | 2 | None | 2 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 302 | 10 | 2 | 2 | 4.7 | CC(C)CCCCCCOc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
| 11740144 | 63032 | 0 | None | -15 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 374 | 8 | 1 | 2 | 5.2 | CCCN(CCCc1ccccc1)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL1788197 | 63032 | 0 | None | -15 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 374 | 8 | 1 | 2 | 5.2 | CCCN(CCCc1ccccc1)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| 11098166 | 109787 | 0 | None | -5 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 287 | 2 | 3 | 3 | 2.1 | CNC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| CHEMBL323264 | 109787 | 0 | None | -5 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 287 | 2 | 3 | 3 | 2.1 | CNC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| 59636721 | 126222 | 0 | None | - | 1 | Chinese hamster | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 472 | 5 | 0 | 5 | 3.6 | CC(=O)N1CCc2cc(CCN3CCN(c4cccc5cc(C(=O)N6CCC6)oc45)CC3)ccc21 | nan | |||
| CHEMBL3650042 | 126222 | 0 | None | - | 1 | Chinese hamster | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 472 | 5 | 0 | 5 | 3.6 | CC(=O)N1CCc2cc(CCN3CCN(c4cccc5cc(C(=O)N6CCC6)oc45)CC3)ccc21 | nan | |||
| 2762737 | 101850 | 20 | None | -35 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 230 | 4 | 1 | 1 | 3.4 | CC(C)c1ccc2[nH]cc(CCN(C)C)c2c1 | 10.1016/s0960-894x(00)00322-x | |||
| CHEMBL300519 | 101850 | 20 | None | -35 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 230 | 4 | 1 | 1 | 3.4 | CC(C)c1ccc2[nH]cc(CCN(C)C)c2c1 | 10.1016/s0960-894x(00)00322-x | |||
| 44376280 | 119903 | 0 | None | -11 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 449 | 6 | 1 | 3 | 4.6 | Cc1ccc(S(=O)(=O)N2CC=C(c3ccc4[nH]cc(CCN5CCCC5)c4c3)CC2)cc1 | 10.1016/j.bmcl.2003.11.023 | |||
| CHEMBL349174 | 119903 | 0 | None | -11 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 449 | 6 | 1 | 3 | 4.6 | Cc1ccc(S(=O)(=O)N2CC=C(c3ccc4[nH]cc(CCN5CCCC5)c4c3)CC2)cc1 | 10.1016/j.bmcl.2003.11.023 | |||
| 44376588 | 119952 | 0 | None | -12 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 465 | 7 | 1 | 4 | 4.3 | COc1ccc(S(=O)(=O)N2CC=C(c3ccc4[nH]cc(CCN5CCCC5)c4c3)CC2)cc1 | 10.1016/j.bmcl.2003.11.023 | |||
| CHEMBL349675 | 119952 | 0 | None | -12 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 465 | 7 | 1 | 4 | 4.3 | COc1ccc(S(=O)(=O)N2CC=C(c3ccc4[nH]cc(CCN5CCCC5)c4c3)CC2)cc1 | 10.1016/j.bmcl.2003.11.023 | |||
| 59636711 | 126225 | 0 | None | - | 1 | Chinese hamster | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 408 | 6 | 0 | 6 | 2.9 | COc1cc(N2CCN(CCc3ccccn3)CC2)c2oc(C(=O)N(C)C)cc2c1 | nan | |||
| CHEMBL3650045 | 126225 | 0 | None | - | 1 | Chinese hamster | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 408 | 6 | 0 | 6 | 2.9 | COc1cc(N2CCN(CCc3ccccn3)CC2)c2oc(C(=O)N(C)C)cc2c1 | nan | |||
| 10683472 | 199387 | 0 | None | - | 1 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 270 | 3 | 1 | 4 | 2.4 | N#CC1=Cc2cccc(OCC3CCCNC3)c2OC1 | 10.1021/jm970806i | |||
| CHEMBL59102 | 199387 | 0 | None | - | 1 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 270 | 3 | 1 | 4 | 2.4 | N#CC1=Cc2cccc(OCC3CCCNC3)c2OC1 | 10.1021/jm970806i | |||
| 10066481 | 18476 | 0 | None | -371 | 3 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 350 | 2 | 0 | 4 | 3.1 | c1ccc2c(c1)CC(N1CCN(c3cccc4c3OCCCO4)CC1)C2 | 10.1021/jm00020a020 | |||
| CHEMBL127216 | 18476 | 0 | None | -371 | 3 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 350 | 2 | 0 | 4 | 3.1 | c1ccc2c(c1)CC(N1CCN(c3cccc4c3OCCCO4)CC1)C2 | 10.1021/jm00020a020 | |||
| 10247055 | 116140 | 0 | None | -501 | 2 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 346 | 5 | 0 | 3 | 4.7 | c1ccc2c(c1)CC2CCCN1CCN(c2cccc3ccoc23)CC1 | 10.1021/jm00020a020 | |||
| CHEMBL335752 | 116140 | 0 | None | -501 | 2 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 346 | 5 | 0 | 3 | 4.7 | c1ccc2c(c1)CC2CCCN1CCN(c2cccc3ccoc23)CC1 | 10.1021/jm00020a020 | |||
| 3191 | 102858 | 97 | None | -17 | 25 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | nan | |||
| CHEMBL305660 | 102858 | 97 | None | -17 | 25 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | nan | |||
| 10062659 | 204174 | 1 | None | -93 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 288 | 5 | 1 | 1 | 4.3 | CCCN(CCC)[C@@H]1CCc2cc(F)c3[nH]ccc3c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL70710 | 204174 | 1 | None | -93 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 288 | 5 | 1 | 1 | 4.3 | CCCN(CCC)[C@@H]1CCc2cc(F)c3[nH]ccc3c2C1 | 10.1021/jm00012a021 | |||
| 12406830 | 65272 | 2 | None | -26 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 267 | 1 | 2 | 1 | 2.2 | Cc1cc(Br)cc(C)c1N=C1NCCN1 | 10.1016/j.bmcl.2004.06.085 | |||
| CHEMBL182837 | 65272 | 2 | None | -26 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 267 | 1 | 2 | 1 | 2.2 | Cc1cc(Br)cc(C)c1N=C1NCCN1 | 10.1016/j.bmcl.2004.06.085 | |||
| 132060743 | 162236 | 0 | None | -5 | 13 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 351 | 3 | 0 | 4 | 3.1 | CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1 | 10.1016/j.ejmech.2018.02.024 | |||
| CHEMBL4163428 | 162236 | 0 | None | -5 | 13 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 351 | 3 | 0 | 4 | 3.1 | CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1 | 10.1016/j.ejmech.2018.02.024 | |||
| 1971 | 2866 | 38 | None | -18 | 30 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | nan | |||
| 2404 | 2866 | 38 | None | -18 | 30 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | nan | |||
| 4543 | 2866 | 38 | None | -18 | 30 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | nan | |||
| CHEMBL445 | 2866 | 38 | None | -18 | 30 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | nan | |||
| DB00540 | 2866 | 38 | None | -18 | 30 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | nan | |||
| 76326512 | 106250 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 376 | 4 | 0 | 3 | 2.8 | CN1CCN(CCOc2ccc(Br)cc2Br)CC1 | 10.1007/s00044-009-9164-1 | |||
| CHEMBL2260924 | 106250 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 376 | 4 | 0 | 3 | 2.8 | CN1CCN(CCOc2ccc(Br)cc2Br)CC1 | 10.1007/s00044-009-9164-1 | |||
| CHEMBL3138935 | 106250 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 376 | 4 | 0 | 3 | 2.8 | CN1CCN(CCOc2ccc(Br)cc2Br)CC1 | 10.1007/s00044-009-9164-1 | |||
| 44438464 | 147140 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 508 | 7 | 1 | 7 | 4.9 | OCC1(N2CCN(C3CCc4ccc(OCc5noc(-c6ccc(Cl)cc6)n5)cc43)CC2)CCCC1 | 10.1016/j.bmcl.2006.12.109 | |||
| CHEMBL392770 | 147140 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 508 | 7 | 1 | 7 | 4.9 | OCC1(N2CCN(C3CCc4ccc(OCc5noc(-c6ccc(Cl)cc6)n5)cc43)CC2)CCCC1 | 10.1016/j.bmcl.2006.12.109 | |||
| 44431537 | 145241 | 0 | None | -15 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 440 | 5 | 1 | 5 | 3.6 | N#Cc1ccc2c(N3CCN(CC[C@@H]4OCCc5cc(C(N)=O)ccc54)CC3)cccc2c1 | 10.1016/j.bmcl.2007.03.101 | |||
| CHEMBL391273 | 145241 | 0 | None | -15 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 440 | 5 | 1 | 5 | 3.6 | N#Cc1ccc2c(N3CCN(CC[C@@H]4OCCc5cc(C(N)=O)ccc54)CC3)cccc2c1 | 10.1016/j.bmcl.2007.03.101 | |||
| 11200511 | 201730 | 0 | None | -15 | 8 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 403 | 5 | 2 | 3 | 4.3 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3ccccc3Cl)cc12 | 10.1021/jm049243i | |||
| CHEMBL606547 | 201730 | 0 | None | -15 | 8 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 403 | 5 | 2 | 3 | 4.3 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3ccccc3Cl)cc12 | 10.1021/jm049243i | |||
| 10068933 | 103801 | 0 | None | -3 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 389 | 8 | 1 | 4 | 4.5 | COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1CCCN(C)C | 10.1021/jm9702948 | |||
| CHEMBL309021 | 103801 | 0 | None | -3 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 389 | 8 | 1 | 4 | 4.5 | COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1CCCN(C)C | 10.1021/jm9702948 | |||
| 44292365 | 188110 | 0 | None | -61 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 270 | 2 | 1 | 1 | 4.1 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C(C)(C)C)cc12 | 10.1016/s0960-894x(00)00322-x | |||
| CHEMBL49826 | 188110 | 0 | None | -61 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 270 | 2 | 1 | 1 | 4.1 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C(C)(C)C)cc12 | 10.1016/s0960-894x(00)00322-x | |||
| 69836292 | 79018 | 0 | None | 15 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 438 | 5 | 0 | 6 | 3.3 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Cc1cccc([N+](=O)[O-])c1)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| CHEMBL2113098 | 79018 | 0 | None | 15 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 438 | 5 | 0 | 6 | 3.3 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Cc1cccc([N+](=O)[O-])c1)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| 10238565 | 190926 | 0 | None | -15 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.7 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCN[C@@H](C)C5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| CHEMBL518545 | 190926 | 0 | None | -15 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.7 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCN[C@@H](C)C5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| 10194809 | 188126 | 0 | None | -25 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 431 | 8 | 1 | 4 | 5.2 | CCC(=O)Nc1cccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm8001444 | |||
| CHEMBL498354 | 188126 | 0 | None | -25 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 431 | 8 | 1 | 4 | 5.2 | CCC(=O)Nc1cccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm8001444 | |||
| 44404230 | 70519 | 0 | None | -1 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 440 | 2 | 0 | 4 | 4.2 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccccc2C(F)(F)F)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
| CHEMBL194701 | 70519 | 0 | None | -1 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 440 | 2 | 0 | 4 | 4.2 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2ccccc2C(F)(F)F)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
| 44404245 | 71908 | 0 | None | -6 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 391 | 2 | 0 | 6 | 2.8 | Cc1nc(C)c(C(=O)N2CCc3cc4ccnc(N5CCN(C)CC5)c4cc32)o1 | 10.1016/j.bmcl.2005.06.042 | |||
| CHEMBL197169 | 71908 | 0 | None | -6 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 391 | 2 | 0 | 6 | 2.8 | Cc1nc(C)c(C(=O)N2CCc3cc4ccnc(N5CCN(C)CC5)c4cc32)o1 | 10.1016/j.bmcl.2005.06.042 | |||
| 10774576 | 208243 | 7 | None | 1 | 3 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 204 | 3 | 1 | 2 | 2.0 | CCCc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
| CHEMBL9870 | 208243 | 7 | None | 1 | 3 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 204 | 3 | 1 | 2 | 2.0 | CCCc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
| 10048252 | 11380 | 0 | None | -41 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 428 | 3 | 0 | 5 | 3.7 | Cc1ccccc1N1CCN(C(=O)Oc2ccc(Cl)c(N3CCN(C)CC3)c2)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL107772 | 11380 | 0 | None | -41 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 428 | 3 | 0 | 5 | 3.7 | Cc1ccccc1N1CCN(C(=O)Oc2ccc(Cl)c(N3CCN(C)CC3)c2)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL1179973 | 11380 | 0 | None | -41 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 428 | 3 | 0 | 5 | 3.7 | Cc1ccccc1N1CCN(C(=O)Oc2ccc(Cl)c(N3CCN(C)CC3)c2)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| 11035452 | 5004 | 0 | None | -12 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 348 | 3 | 2 | 3 | 3.9 | Cc1ccccc1C(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| CHEMBL105025 | 5004 | 0 | None | -12 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 348 | 3 | 2 | 3 | 3.9 | Cc1ccccc1C(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| 10759257 | 100176 | 0 | None | 7 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 335 | 1 | 0 | 4 | 3.8 | CN1CCN(c2nc3ccccc3c3c2CCc2sccc2-3)CC1 | 10.1021/jm981112s | |||
| CHEMBL288069 | 100176 | 0 | None | 7 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 335 | 1 | 0 | 4 | 3.8 | CN1CCN(c2nc3ccccc3c3c2CCc2sccc2-3)CC1 | 10.1021/jm981112s | |||
| 3604129 | 30264 | 5 | None | -19 | 3 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 215 | 4 | 0 | 2 | 2.8 | CN(C)CCOc1cccc2ccccc12 | 10.1021/jm00124a021 | |||
| CHEMBL139103 | 30264 | 5 | None | -19 | 3 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 215 | 4 | 0 | 2 | 2.8 | CN(C)CCOc1cccc2ccccc12 | 10.1021/jm00124a021 | |||
| 10398118 | 102121 | 0 | None | -11 | 5 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 207 | 3 | 1 | 1 | 2.7 | CCCNC1CCc2cc(F)ccc2C1 | 10.1021/jm00012a021 | |||
| CHEMBL302373 | 102121 | 0 | None | -11 | 5 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 207 | 3 | 1 | 1 | 2.7 | CCCNC1CCc2cc(F)ccc2C1 | 10.1021/jm00012a021 | |||
| 10088157 | 22879 | 0 | None | -1071 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 332 | 4 | 0 | 3 | 4.3 | c1ccc2c(c1)CC2CCN1CCN(c2cccc3ccoc23)CC1 | 10.1021/jm00020a020 | |||
| CHEMBL132878 | 22879 | 0 | None | -1071 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 332 | 4 | 0 | 3 | 4.3 | c1ccc2c(c1)CC2CCN1CCN(c2cccc3ccoc23)CC1 | 10.1021/jm00020a020 | |||
| 854157 | 77864 | 15 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 174 | 2 | 2 | 1 | 2.1 | C[C@H](N)Cc1c[nH]c2ccccc12 | 10.1021/jm00402a026 | |||
| CHEMBL2093087 | 77864 | 15 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 174 | 2 | 2 | 1 | 2.1 | C[C@H](N)Cc1c[nH]c2ccccc12 | 10.1021/jm00402a026 | |||
| 10070281 | 205561 | 0 | None | -28 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 412 | 5 | 1 | 3 | 4.7 | NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2cccc3ccccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
| CHEMBL81191 | 205561 | 0 | None | -28 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 412 | 5 | 1 | 3 | 4.7 | NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2cccc3ccccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
| 752521 | 198737 | 8 | None | -74 | 9 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 295 | 1 | 3 | 5 | 1.9 | CC1(C)N=C(N)N=C(Nc2cccc(Br)c2)N1 | 10.1021/acs.jmedchem.5b01631 | |||
| CHEMBL582877 | 198737 | 8 | None | -74 | 9 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 295 | 1 | 3 | 5 | 1.9 | CC1(C)N=C(N)N=C(Nc2cccc(Br)c2)N1 | 10.1021/acs.jmedchem.5b01631 | |||
| 14083215 | 63067 | 2 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 190 | 2 | 3 | 2 | 1.8 | C[C@@H](N)Cc1c[nH]c2cccc(O)c12 | 10.1021/jm00402a026 | |||
| CHEMBL1788284 | 63067 | 2 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 190 | 2 | 3 | 2 | 1.8 | C[C@@H](N)Cc1c[nH]c2cccc(O)c12 | 10.1021/jm00402a026 | |||
| 44461149 | 205369 | 0 | None | -4 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 421 | 5 | 1 | 5 | 3.9 | NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2noc3cc(F)ccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
| CHEMBL79853 | 205369 | 0 | None | -4 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 421 | 5 | 1 | 5 | 3.9 | NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2noc3cc(F)ccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
| 44461298 | 205715 | 0 | None | -7 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 420 | 5 | 1 | 4 | 4.5 | NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2coc3cc(F)ccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
| CHEMBL82488 | 205715 | 0 | None | -7 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 420 | 5 | 1 | 4 | 4.5 | NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2coc3cc(F)ccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
| 31703 | 194717 | 63 | None | -1 | 2 | Rat | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | nan | |||
| CHEMBL359744 | 194717 | 63 | None | -1 | 2 | Rat | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | nan | |||
| CHEMBL53463 | 194717 | 63 | None | -1 | 2 | Rat | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | nan | |||
| 9795333 | 103075 | 0 | None | -21 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 266 | 2 | 1 | 2 | 2.6 | Cc1cc(Br)cc(C)c1CC1=NCCN1 | 10.1016/j.bmcl.2004.06.085 | |||
| CHEMBL307408 | 103075 | 0 | None | -21 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 266 | 2 | 1 | 2 | 2.6 | Cc1cc(Br)cc(C)c1CC1=NCCN1 | 10.1016/j.bmcl.2004.06.085 | |||
| 9795333 | 103075 | 0 | None | -21 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 266 | 2 | 1 | 2 | 2.6 | Cc1cc(Br)cc(C)c1CC1=NCCN1 | 10.1021/jm970513p | |||
| CHEMBL307408 | 103075 | 0 | None | -21 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 266 | 2 | 1 | 2 | 2.6 | Cc1cc(Br)cc(C)c1CC1=NCCN1 | 10.1021/jm970513p | |||
| 46945446 | 17762 | 0 | None | 5 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 408 | 9 | 0 | 5 | 4.6 | CCCCOc1ccc(-c2nn3c(C)cc(C)nc3c2CC(=O)N(CC)CC)cc1 | 10.1016/j.bmcl.2010.07.135 | |||
| CHEMBL1258723 | 17762 | 0 | None | 5 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 408 | 9 | 0 | 5 | 4.6 | CCCCOc1ccc(-c2nn3c(C)cc(C)nc3c2CC(=O)N(CC)CC)cc1 | 10.1016/j.bmcl.2010.07.135 | |||
| 22132555 | 13708 | 0 | None | -12 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 398 | 7 | 2 | 3 | 4.0 | N#Cc1ccc2c(c1)CN(CCCCNC(=O)/C=C/c1c[nH]c3ccccc13)CC2 | 10.1021/jm000090i | |||
| CHEMBL1194956 | 13708 | 0 | None | -12 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 398 | 7 | 2 | 3 | 4.0 | N#Cc1ccc2c(c1)CN(CCCCNC(=O)/C=C/c1c[nH]c3ccccc13)CC2 | 10.1021/jm000090i | |||
| CHEMBL553591 | 13708 | 0 | None | -12 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 398 | 7 | 2 | 3 | 4.0 | N#Cc1ccc2c(c1)CN(CCCCNC(=O)/C=C/c1c[nH]c3ccccc13)CC2 | 10.1021/jm000090i | |||
| 10597855 | 84389 | 0 | None | -125 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 413 | 6 | 1 | 3 | 4.7 | N#Cc1ccc2c(c1)CN(CC[C@H]1CC[C@H](NC(=O)/C=C/c3ccccc3)CC1)CC2 | 10.1021/jm000090i | |||
| CHEMBL2113350 | 84389 | 0 | None | -125 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 413 | 6 | 1 | 3 | 4.7 | N#Cc1ccc2c(c1)CN(CC[C@H]1CC[C@H](NC(=O)/C=C/c3ccccc3)CC1)CC2 | 10.1021/jm000090i | |||
| CHEMBL2219579 | 84389 | 0 | None | -125 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 413 | 6 | 1 | 3 | 4.7 | N#Cc1ccc2c(c1)CN(CC[C@H]1CC[C@H](NC(=O)/C=C/c3ccccc3)CC1)CC2 | 10.1021/jm000090i | |||
| 10194297 | 78989 | 0 | None | -50 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 400 | 6 | 1 | 4 | 4.2 | Cc1ccc2c(OCCN3CCN(Cc4ccc5[nH]ccc5c4)CC3)cccc2n1 | 10.1021/jm049039v | |||
| CHEMBL2113061 | 78989 | 0 | None | -50 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 400 | 6 | 1 | 4 | 4.2 | Cc1ccc2c(OCCN3CCN(Cc4ccc5[nH]ccc5c4)CC3)cccc2n1 | 10.1021/jm049039v | |||
| 10115847 | 91980 | 0 | None | -3 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 465 | 6 | 1 | 5 | 4.9 | Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)ccc(Cl)c2n1 | 10.1016/j.bmcl.2006.11.031 | |||
| CHEMBL241500 | 91980 | 0 | None | -3 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 465 | 6 | 1 | 5 | 4.9 | Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)ccc(Cl)c2n1 | 10.1016/j.bmcl.2006.11.031 | |||
| 44581604 | 176059 | 0 | None | -39 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 485 | 7 | 0 | 4 | 5.6 | CC(=O)N1CCC(c2cccc(CC3CCN(CCOc4cccc5nc(C)ccc45)CC3)c2)CC1 | 10.1016/j.bmcl.2008.11.052 | |||
| CHEMBL459068 | 176059 | 0 | None | -39 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 485 | 7 | 0 | 4 | 5.6 | CC(=O)N1CCC(c2cccc(CC3CCN(CCOc4cccc5nc(C)ccc45)CC3)c2)CC1 | 10.1016/j.bmcl.2008.11.052 | |||
| 10174088 | 189498 | 0 | None | -100 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 473 | 7 | 0 | 5 | 5.5 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5C[C@H](C)O[C@H](C)C5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| CHEMBL513955 | 189498 | 0 | None | -100 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 473 | 7 | 0 | 5 | 5.5 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5C[C@H](C)O[C@H](C)C5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| 10172853 | 187646 | 0 | None | -63 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 391 | 7 | 0 | 5 | 3.7 | COc1cccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm8001444 | |||
| CHEMBL494992 | 187646 | 0 | None | -63 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 391 | 7 | 0 | 5 | 3.7 | COc1cccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm8001444 | |||
| 9954121 | 96406 | 0 | None | -2511 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 424 | 4 | 2 | 5 | 3.7 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc3nccc(N4CCNCC4)c3c2)cc1 | 10.1016/s0960-894x(01)00558-3 | |||
| CHEMBL261917 | 96406 | 0 | None | -2511 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 424 | 4 | 2 | 5 | 3.7 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc3nccc(N4CCNCC4)c3c2)cc1 | 10.1016/s0960-894x(01)00558-3 | |||
| 9863250 | 17995 | 6 | None | -512 | 7 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 350 | 5 | 0 | 3 | 3.3 | Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1 | 10.1021/jm991151j | |||
| CHEMBL12624 | 17995 | 6 | None | -512 | 7 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 350 | 5 | 0 | 3 | 3.3 | Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1 | 10.1021/jm991151j | |||
| 10835110 | 114588 | 0 | None | -398 | 8 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 404 | 5 | 0 | 3 | 4.3 | CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm991151j | |||
| CHEMBL333784 | 114588 | 0 | None | -398 | 8 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 404 | 5 | 0 | 3 | 4.3 | CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm991151j | |||
| 11248705 | 90295 | 0 | None | -630 | 10 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 483 | 6 | 1 | 5 | 5.0 | Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(Cl)cc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
| CHEMBL238519 | 90295 | 0 | None | -630 | 10 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 483 | 6 | 1 | 5 | 5.0 | Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(Cl)cc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
| 24865541 | 187677 | 0 | None | -316 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 418 | 7 | 1 | 5 | 3.7 | CC(=O)Nc1ccccc1CN1CCN(CCOc2cccc3nc(C)ccc23)CC1 | 10.1021/jm8001444 | |||
| CHEMBL495161 | 187677 | 0 | None | -316 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 418 | 7 | 1 | 5 | 3.7 | CC(=O)Nc1ccccc1CN1CCN(CCOc2cccc3nc(C)ccc23)CC1 | 10.1021/jm8001444 | |||
| 10543269 | 26587 | 0 | None | -3 | 3 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 314 | 3 | 1 | 5 | 1.7 | OCCN1CCN(c2nc3cccc(F)c3n3cccc23)CC1 | 10.1021/jm990151g | |||
| CHEMBL136108 | 26587 | 0 | None | -3 | 3 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 314 | 3 | 1 | 5 | 1.7 | OCCN1CCN(c2nc3cccc(F)c3n3cccc23)CC1 | 10.1021/jm990151g | |||
| 24881201 | 186849 | 0 | None | -4 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 526 | 6 | 4 | 4 | 5.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)CC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
| CHEMBL489453 | 186849 | 0 | None | -4 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 526 | 6 | 4 | 4 | 5.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)CC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | 10.1021/jm7011722 | |||
| 59636729 | 125691 | 0 | None | - | 1 | Chinese hamster | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 390 | 5 | 0 | 5 | 3.0 | O=C(c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1)N1CCC1 | nan | |||
| CHEMBL3647273 | 125691 | 0 | None | - | 1 | Chinese hamster | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 390 | 5 | 0 | 5 | 3.0 | O=C(c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1)N1CCC1 | nan | |||
| 10786335 | 12060 | 0 | None | 63 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 385 | 5 | 1 | 4 | 3.9 | COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1C#CCN(C)C | 10.1021/jm9702948 | |||
| CHEMBL118360 | 12060 | 0 | None | 63 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 385 | 5 | 1 | 4 | 3.9 | COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1C#CCN(C)C | 10.1021/jm9702948 | |||
| 44403105 | 72108 | 0 | None | 19 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 455 | 5 | 1 | 6 | 3.5 | COc1ccc(NC(=O)N2CCN(c3ccc(SC)cc3)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
| CHEMBL197796 | 72108 | 0 | None | 19 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 455 | 5 | 1 | 6 | 3.5 | COc1ccc(NC(=O)N2CCN(c3ccc(SC)cc3)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
| CHEMBL5084249 | 214905 | 0 | None | -19 | 8 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | None | None | None | CCN(CC)CCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
| CHEMBL5094493 | 215499 | 0 | None | -7 | 7 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | None | None | None | CCCN(CCC)CCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
| 11810310 | 4718 | 0 | None | -144 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccc(F)c4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL103550 | 4718 | 0 | None | -144 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccc(F)c4)nc23)CC1 | 10.1021/jm030020m | |||
| 122187375 | 123023 | 0 | None | -5 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 443 | 5 | 0 | 5 | 5.6 | CCCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4 | 10.1016/j.bmcl.2015.07.012 | |||
| CHEMBL3609140 | 123023 | 0 | None | -5 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 443 | 5 | 0 | 5 | 5.6 | CCCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4 | 10.1016/j.bmcl.2015.07.012 | |||
| 10049500 | 77821 | 0 | None | -1071 | 5 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 451 | 9 | 1 | 4 | 4.5 | CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)[C@H]1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL2092864 | 77821 | 0 | None | -1071 | 5 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 451 | 9 | 1 | 4 | 4.5 | CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)[C@H]1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL2112317 | 77821 | 0 | None | -1071 | 5 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 451 | 9 | 1 | 4 | 4.5 | CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)[C@H]1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| 15870567 | 186973 | 0 | None | -36 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 242 | 4 | 1 | 1 | 3.4 | CCc1ccc2[nH]cc(CCN3CCCC3)c2c1 | 10.1016/s0960-894x(00)00322-x | |||
| CHEMBL49048 | 186973 | 0 | None | -36 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 242 | 4 | 1 | 1 | 3.4 | CCc1ccc2[nH]cc(CCN3CCCC3)c2c1 | 10.1016/s0960-894x(00)00322-x | |||
| 14639163 | 204198 | 4 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 190 | 3 | 1 | 3 | 1.2 | COc1cccc(CC2=NCCN2)c1 | 10.1021/jm970513p | |||
| CHEMBL70831 | 204198 | 4 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 190 | 3 | 1 | 3 | 1.2 | COc1cccc(CC2=NCCN2)c1 | 10.1021/jm970513p | |||
| 168268877 | 189970 | 0 | None | -35 | 12 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 328 | 2 | 3 | 3 | 3.8 | COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1 | 10.1021/acsmedchemlett.1c00694 | |||
| CHEMBL5170784 | 189970 | 0 | None | -35 | 12 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 328 | 2 | 3 | 3 | 3.8 | COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1 | 10.1021/acsmedchemlett.1c00694 | |||
| 10425027 | 204212 | 0 | None | -31 | 5 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 302 | 5 | 0 | 2 | 4.3 | CCCN(CCC)C1CCc2cc(F)c3c(ccn3C)c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL70882 | 204212 | 0 | None | -31 | 5 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 302 | 5 | 0 | 2 | 4.3 | CCCN(CCC)C1CCc2cc(F)c3c(ccn3C)c2C1 | 10.1021/jm00012a021 | |||
| 16117151 | 60087 | 0 | None | -1659 | 7 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 390 | 4 | 3 | 5 | 3.2 | O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12 | 10.1016/j.bmc.2010.10.033 | |||
| CHEMBL1642882 | 60087 | 0 | None | -1659 | 7 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 390 | 4 | 3 | 5 | 3.2 | O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12 | 10.1016/j.bmc.2010.10.033 | |||
| CHEMBL1739102 | 60087 | 0 | None | -1659 | 7 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 390 | 4 | 3 | 5 | 3.2 | O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12 | 10.1016/j.bmc.2010.10.033 | |||
| 14547415 | 100671 | 1 | None | -10 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 214 | 1 | 1 | 1 | 2.6 | CN(C)[C@H]1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL292274 | 100671 | 1 | None | -10 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 214 | 1 | 1 | 1 | 2.6 | CN(C)[C@H]1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
| 180 | 401 | 56 | None | -389 | 40 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | |||
| 200 | 401 | 56 | None | -389 | 40 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | |||
| 2160 | 401 | 56 | None | -389 | 40 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | |||
| CHEMBL629 | 401 | 56 | None | -389 | 40 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | |||
| DB00321 | 401 | 56 | None | -389 | 40 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | |||
| 44214329 | 59439 | 0 | None | -33 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 270 | 4 | 1 | 2 | 4.0 | CN(C)CCc1c[nH]c2ccc(-c3ccsc3)cc12 | 10.1016/s0960-894x(00)00133-5 | |||
| CHEMBL171129 | 59439 | 0 | None | -33 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 270 | 4 | 1 | 2 | 4.0 | CN(C)CCc1c[nH]c2ccc(-c3ccsc3)cc12 | 10.1016/s0960-894x(00)00133-5 | |||
| 44342969 | 10528 | 0 | None | -21 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 449 | 5 | 1 | 3 | 4.6 | Cc1ccc(S(=O)(=O)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1 | 10.1016/s0960-894x(03)00779-0 | |||
| CHEMBL116876 | 10528 | 0 | None | -21 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 449 | 5 | 1 | 3 | 4.6 | Cc1ccc(S(=O)(=O)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1 | 10.1016/s0960-894x(03)00779-0 | |||
| 59636726 | 125706 | 0 | None | - | 1 | Chinese hamster | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 458 | 8 | 1 | 7 | 2.9 | Cn1cnc(CCNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)c1 | nan | |||
| CHEMBL3647288 | 125706 | 0 | None | - | 1 | Chinese hamster | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 458 | 8 | 1 | 7 | 2.9 | Cn1cnc(CCNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)c1 | nan | |||
| 2477 | 745 | 59 | None | -16 | 29 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00027a013 | |||
| 36 | 745 | 59 | None | -16 | 29 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00027a013 | |||
| 437 | 745 | 59 | None | -16 | 29 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00027a013 | |||
| CHEMBL49 | 745 | 59 | None | -16 | 29 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00027a013 | |||
| DB00490 | 745 | 59 | None | -16 | 29 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm00027a013 | |||
| 2303 | 3187 | 68 | None | -57 | 26 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm00124a021 | |||
| 4946 | 3187 | 68 | None | -57 | 26 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm00124a021 | |||
| 564 | 3187 | 68 | None | -57 | 26 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm00124a021 | |||
| 63 | 3187 | 68 | None | -57 | 26 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm00124a021 | |||
| 91536 | 3187 | 68 | None | -57 | 26 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm00124a021 | |||
| CHEMBL27 | 3187 | 68 | None | -57 | 26 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm00124a021 | |||
| CHEMBL452861 | 3187 | 68 | None | -57 | 26 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm00124a021 | |||
| DB00571 | 3187 | 68 | None | -57 | 26 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm00124a021 | |||
| 1346 | 83 | 117 | None | -40 | 9 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 192 | 2 | 1 | 3 | 1.1 | COc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
| 280 | 83 | 117 | None | -40 | 9 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 192 | 2 | 1 | 3 | 1.1 | COc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
| 9899402 | 83 | 117 | None | -40 | 9 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 192 | 2 | 1 | 3 | 1.1 | COc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
| CHEMBL9666 | 83 | 117 | None | -40 | 9 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 192 | 2 | 1 | 3 | 1.1 | COc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
| 44376283 | 56508 | 0 | None | -5 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 488 | 6 | 2 | 3 | 5.9 | S=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)C12CC3CC(CC(C3)C1)C2 | 10.1016/j.bmcl.2003.11.023 | |||
| CHEMBL163516 | 56508 | 0 | None | -5 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 488 | 6 | 2 | 3 | 5.9 | S=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)C12CC3CC(CC(C3)C1)C2 | 10.1016/j.bmcl.2003.11.023 | |||
| 11465618 | 102398 | 23 | None | -630 | 19 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 354 | 2 | 0 | 2 | 4.9 | CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C | 10.1016/j.bmcl.2022.128879 | |||
| CHEMBL3039528 | 102398 | 23 | None | -630 | 19 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 354 | 2 | 0 | 2 | 4.9 | CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C | 10.1016/j.bmcl.2022.128879 | |||
| CHEMBL5191141 | 102398 | 23 | None | -630 | 19 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 354 | 2 | 0 | 2 | 4.9 | CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C | 10.1016/j.bmcl.2022.128879 | |||
| 22184640 | 85177 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 519 | 8 | 2 | 7 | 3.5 | CCN1CCC(N(CC)c2cc(OC)cc3c(=O)cc(C(=O)Nc4ccc(N5CCOCC5)cc4)[nH]c23)C1 | 10.1016/j.bmc.2006.10.037 | |||
| CHEMBL225310 | 85177 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 519 | 8 | 2 | 7 | 3.5 | CCN1CCC(N(CC)c2cc(OC)cc3c(=O)cc(C(=O)Nc4ccc(N5CCOCC5)cc4)[nH]c23)C1 | 10.1016/j.bmc.2006.10.037 | |||
| 11011968 | 4941 | 0 | None | -173 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 298 | 3 | 2 | 3 | 2.7 | CN1CCC(c2c[nH]c3ccc(NC(=O)C4CC4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL104720 | 4941 | 0 | None | -173 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 298 | 3 | 2 | 3 | 2.7 | CN1CCC(c2c[nH]c3ccc(NC(=O)C4CC4)nc23)CC1 | 10.1021/jm030020m | |||
| 10618751 | 35190 | 0 | None | -4 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 364 | 7 | 1 | 4 | 3.3 | CCN(CC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
| CHEMBL143510 | 35190 | 0 | None | -4 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 364 | 7 | 1 | 4 | 3.3 | CCN(CC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
| 10496545 | 9327 | 0 | None | 13 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 328 | 9 | 2 | 2 | 5.1 | CCCCCCCCCOc1ccc2[nH]c3c(c2c1)CC(N)CC3 | 10.1021/jm950498t | |||
| CHEMBL111107 | 9327 | 0 | None | 13 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 328 | 9 | 2 | 2 | 5.1 | CCCCCCCCCOc1ccc2[nH]c3c(c2c1)CC(N)CC3 | 10.1021/jm950498t | |||
| CHEMBL4520788 | 213975 | 10 | None | -83 | 25 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | None | None | None | CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1 | 10.6019/CHEMBL5212743 | |||||
| 10088038 | 204356 | 0 | None | -30 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 330 | 7 | 1 | 1 | 5.2 | CCCc1c[nH]c2c(F)cc3c(c12)CC(N(CCC)CCC)CC3 | 10.1021/jm00012a021 | |||
| CHEMBL71663 | 204356 | 0 | None | -30 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 330 | 7 | 1 | 1 | 5.2 | CCCc1c[nH]c2c(F)cc3c(c12)CC(N(CCC)CCC)CC3 | 10.1021/jm00012a021 | |||
| 132787 | 3430 | 45 | None | -1000 | 6 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 336 | 2 | 0 | 4 | 2.7 | C1COc2c(O1)cccc2N1CCN(CC1)C1Cc2c(C1)cccc2 | 10.1021/jm00020a020 | |||
| 26 | 3430 | 45 | None | -1000 | 6 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 336 | 2 | 0 | 4 | 2.7 | C1COc2c(O1)cccc2N1CCN(CC1)C1Cc2c(C1)cccc2 | 10.1021/jm00020a020 | |||
| 32 | 3430 | 45 | None | -1000 | 6 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 336 | 2 | 0 | 4 | 2.7 | C1COc2c(O1)cccc2N1CCN(CC1)C1Cc2c(C1)cccc2 | 10.1021/jm00020a020 | |||
| CHEMBL49247 | 3430 | 45 | None | -1000 | 6 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 336 | 2 | 0 | 4 | 2.7 | C1COc2c(O1)cccc2N1CCN(CC1)C1Cc2c(C1)cccc2 | 10.1021/jm00020a020 | |||
| 127026052 | 137553 | 0 | None | -107 | 19 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 258 | 7 | 1 | 1 | 3.5 | C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12 | 10.1016/j.bmcl.2015.12.053 | |||
| CHEMBL3754496 | 137553 | 0 | None | -107 | 19 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 258 | 7 | 1 | 1 | 3.5 | C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12 | 10.1016/j.bmcl.2015.12.053 | |||
| 107992 | 2553 | 49 | None | -12 | 10 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 198 | 1 | 1 | 4 | 0.5 | Clc1cncc(n1)N1CCNCC1 | 10.1021/jm00125a020 | |||
| 165 | 2553 | 49 | None | -12 | 10 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 198 | 1 | 1 | 4 | 0.5 | Clc1cncc(n1)N1CCNCC1 | 10.1021/jm00125a020 | |||
| CHEMBL269521 | 2553 | 49 | None | -12 | 10 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 198 | 1 | 1 | 4 | 0.5 | Clc1cncc(n1)N1CCNCC1 | 10.1021/jm00125a020 | |||
| DB12111 | 2553 | 49 | None | -12 | 10 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 198 | 1 | 1 | 4 | 0.5 | Clc1cncc(n1)N1CCNCC1 | 10.1021/jm00125a020 | |||
| 10064361 | 204164 | 0 | None | -223 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 316 | 6 | 1 | 2 | 4.1 | CCCN(CCC)[C@H]1CCc2cc(F)c3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL70652 | 204164 | 0 | None | -223 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 316 | 6 | 1 | 2 | 4.1 | CCCN(CCC)[C@H]1CCc2cc(F)c3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a021 | |||
| 19066188 | 12098 | 0 | None | 19 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 409 | 4 | 1 | 5 | 2.8 | COc1ccc(NC(=O)N2CCN(c3ccccc3)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL1183944 | 12098 | 0 | None | 19 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 409 | 4 | 1 | 5 | 2.8 | COc1ccc(NC(=O)N2CCN(c3ccccc3)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL325131 | 12098 | 0 | None | 19 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 409 | 4 | 1 | 5 | 2.8 | COc1ccc(NC(=O)N2CCN(c3ccccc3)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| 24882268 | 172557 | 0 | None | -11 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 788 | 15 | 4 | 6 | 8.5 | O=C(Nc1ccc2[nH]cc(C3CCN(CCOCCOCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | 10.1021/jm7011722 | |||
| CHEMBL448555 | 172557 | 0 | None | -11 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 788 | 15 | 4 | 6 | 8.5 | O=C(Nc1ccc2[nH]cc(C3CCN(CCOCCOCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | 10.1021/jm7011722 | |||
| 5 | 139 | 72 | None | -11 | 54 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm8007618 | |||
| 5202 | 139 | 72 | None | -11 | 54 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm8007618 | |||
| CHEMBL39 | 139 | 72 | None | -11 | 54 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm8007618 | |||
| DB08839 | 139 | 72 | None | -11 | 54 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm8007618 | |||
| 44404396 | 71457 | 0 | None | 5 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 427 | 4 | 1 | 5 | 2.9 | COc1ccc(NC(=O)N2CCN(c3ccccc3F)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
| CHEMBL196169 | 71457 | 0 | None | 5 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 427 | 4 | 1 | 5 | 2.9 | COc1ccc(NC(=O)N2CCN(c3ccccc3F)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
| 10643939 | 14111 | 0 | None | 35 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 387 | 7 | 1 | 4 | 4.6 | COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1/C=C/CN(C)C | 10.1021/jm9702948 | |||
| CHEMBL119800 | 14111 | 0 | None | 35 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 387 | 7 | 1 | 4 | 4.6 | COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1/C=C/CN(C)C | 10.1021/jm9702948 | |||
| 25263302 | 191984 | 0 | None | -1380 | 5 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 434 | 4 | 2 | 6 | 3.4 | O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCCNC1 | 10.1016/j.bmcl.2009.03.071 | |||
| CHEMBL520129 | 191984 | 0 | None | -1380 | 5 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 434 | 4 | 2 | 6 | 3.4 | O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCCNC1 | 10.1016/j.bmcl.2009.03.071 | |||
| 14011047 | 59029 | 22 | None | -446 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 274 | 8 | 1 | 2 | 3.8 | CCCN(CCC)CCc1c[nH]c2ccc(OC)cc12 | 10.1021/jm00399a031 | |||
| CHEMBL169328 | 59029 | 22 | None | -446 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 274 | 8 | 1 | 2 | 3.8 | CCCN(CCC)CCc1c[nH]c2ccc(OC)cc12 | 10.1021/jm00399a031 | |||
| 14519865 | 31587 | 1 | None | -39 | 4 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 243 | 6 | 0 | 2 | 3.6 | CCCN(C)CCOc1cccc2ccccc12 | 10.1021/jm00124a021 | |||
| CHEMBL140417 | 31587 | 1 | None | -39 | 4 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 243 | 6 | 0 | 2 | 3.6 | CCCN(C)CCOc1cccc2ccccc12 | 10.1021/jm00124a021 | |||
| 117209857 | 185138 | 1 | None | -43 | 8 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 246 | 2 | 2 | 3 | 1.6 | Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
| CHEMBL4856702 | 185138 | 1 | None | -43 | 8 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 246 | 2 | 2 | 3 | 1.6 | Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
| 2726 | 919 | 68 | None | -147 | 72 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | |||
| 621 | 919 | 68 | None | -147 | 72 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | |||
| 83 | 919 | 68 | None | -147 | 72 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | |||
| CHEMBL71 | 919 | 68 | None | -147 | 72 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | |||
| DB00477 | 919 | 68 | None | -147 | 72 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | |||
| 44455426 | 155149 | 0 | None | -26 | 12 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 405 | 9 | 1 | 4 | 4.2 | COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | |||
| CHEMBL402143 | 155149 | 0 | None | -26 | 12 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 405 | 9 | 1 | 4 | 4.2 | COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | |||
| 44460810 | 205623 | 0 | None | -48 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 436 | 5 | 1 | 4 | 4.9 | NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2csc3cc(F)ccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
| CHEMBL81703 | 205623 | 0 | None | -48 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 436 | 5 | 1 | 4 | 4.9 | NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2csc3cc(F)ccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
| 9949568 | 123430 | 0 | None | -61 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 334 | 4 | 0 | 2 | 5.1 | Cc1cc(C(C)(C)C)cc(C)c1CC1=NCCN1Cc1ccccc1 | 10.1016/j.bmcl.2004.06.085 | |||
| CHEMBL361729 | 123430 | 0 | None | -61 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 334 | 4 | 0 | 2 | 5.1 | Cc1cc(C(C)(C)C)cc(C)c1CC1=NCCN1Cc1ccccc1 | 10.1016/j.bmcl.2004.06.085 | |||
| 10068238 | 19719 | 0 | None | -1479 | 2 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 378 | 5 | 0 | 4 | 3.8 | c1ccc2c(c1)CC(CCCN1CCN(c3cccc4c3OCCO4)CC1)C2 | 10.1021/jm00020a020 | |||
| CHEMBL130103 | 19719 | 0 | None | -1479 | 2 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 378 | 5 | 0 | 4 | 3.8 | c1ccc2c(c1)CC(CCCN1CCN(c3cccc4c3OCCO4)CC1)C2 | 10.1021/jm00020a020 | |||
| 10432512 | 102389 | 0 | None | -234 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 424 | 9 | 1 | 3 | 5.7 | CCCN(CCCOc1cccc(Cl)c1)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL303921 | 102389 | 0 | None | -234 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 424 | 9 | 1 | 3 | 5.7 | CCCN(CCCOc1cccc(Cl)c1)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| 10517352 | 7628 | 0 | None | 5 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 286 | 6 | 2 | 2 | 3.9 | CCCCCCOc1ccc2[nH]c3c(c2c1)CC(N)CC3 | 10.1021/jm950498t | |||
| CHEMBL108818 | 7628 | 0 | None | 5 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 286 | 6 | 2 | 2 | 3.9 | CCCCCCOc1ccc2[nH]c3c(c2c1)CC(N)CC3 | 10.1021/jm950498t | |||
| 10500422 | 78475 | 0 | None | 15 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 387 | 7 | 1 | 4 | 4.6 | COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1/C=C\CN(C)C | 10.1021/jm9702948 | |||
| CHEMBL2111779 | 78475 | 0 | None | 15 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 387 | 7 | 1 | 4 | 4.6 | COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1/C=C\CN(C)C | 10.1021/jm9702948 | |||
| 73453 | 29616 | 24 | None | -26 | 17 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 561 | 4 | 3 | 6 | 2.0 | CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 | nan | |||
| CHEMBL1385840 | 29616 | 24 | None | -26 | 17 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 561 | 4 | 3 | 6 | 2.0 | CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 | nan | |||
| 59636772 | 125676 | 0 | None | - | 1 | Chinese hamster | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 441 | 7 | 1 | 6 | 3.5 | O=C(NCc1ccccn1)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| CHEMBL3647259 | 125676 | 0 | None | - | 1 | Chinese hamster | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 441 | 7 | 1 | 6 | 3.5 | O=C(NCc1ccccn1)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| 59636774 | 125705 | 0 | None | - | 1 | Chinese hamster | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 470 | 8 | 1 | 7 | 3.3 | Cc1ccnc(CCNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)n1 | nan | |||
| CHEMBL3647287 | 125705 | 0 | None | - | 1 | Chinese hamster | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 470 | 8 | 1 | 7 | 3.3 | Cc1ccnc(CCNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)n1 | nan | |||
| 59636731 | 126220 | 0 | None | - | 1 | Chinese hamster | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 396 | 5 | 0 | 5 | 3.0 | CN(C)C(=O)c1cc2cccc(N3CCN(CCc4ccc(F)cn4)CC3)c2o1 | nan | |||
| CHEMBL3650040 | 126220 | 0 | None | - | 1 | Chinese hamster | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 396 | 5 | 0 | 5 | 3.0 | CN(C)C(=O)c1cc2cccc(N3CCN(CCc4ccc(F)cn4)CC3)c2o1 | nan | |||
| 2543 | 3707 | 68 | None | -3 | 32 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(98)00090-0 | |||
| 5358 | 3707 | 68 | None | -3 | 32 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(98)00090-0 | |||
| 54 | 3707 | 68 | None | -3 | 32 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(98)00090-0 | |||
| CHEMBL128 | 3707 | 68 | None | -3 | 32 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(98)00090-0 | |||
| DB00669 | 3707 | 68 | None | -3 | 32 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(98)00090-0 | |||
| 44402875 | 70454 | 0 | None | 12 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 413 | 3 | 0 | 4 | 4.1 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)c1cccc(Cl)c1)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| CHEMBL194610 | 70454 | 0 | None | 12 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 413 | 3 | 0 | 4 | 4.1 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)c1cccc(Cl)c1)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| 10161028 | 90772 | 0 | None | -39 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 449 | 6 | 1 | 5 | 4.3 | Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
| CHEMBL239168 | 90772 | 0 | None | -39 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 449 | 6 | 1 | 5 | 4.3 | Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cccc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
| 10237964 | 187614 | 0 | None | -39 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 418 | 7 | 1 | 5 | 3.7 | CC(=O)Nc1cccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm8001444 | |||
| CHEMBL494806 | 187614 | 0 | None | -39 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 418 | 7 | 1 | 5 | 3.7 | CC(=O)Nc1cccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm8001444 | |||
| 10216873 | 187800 | 0 | None | -9 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 443 | 7 | 0 | 4 | 5.0 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCC5=O)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
| CHEMBL495895 | 187800 | 0 | None | -9 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 443 | 7 | 0 | 4 | 5.0 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCC5=O)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
| 10173263 | 193399 | 0 | None | -39 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 417 | 7 | 1 | 4 | 4.8 | CC(=O)Nc1cccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm8001444 | |||
| CHEMBL525712 | 193399 | 0 | None | -39 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 417 | 7 | 1 | 4 | 4.8 | CC(=O)Nc1cccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm8001444 | |||
| 9867475 | 18013 | 0 | None | -63 | 9 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 432 | 7 | 0 | 5 | 4.2 | CN(C)CCc1cccc2c1cc(C(=O)c1ccccc1)n2S(=O)(=O)c1ccccc1 | 10.1021/jm010943m | |||
| CHEMBL126340 | 18013 | 0 | None | -63 | 9 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 432 | 7 | 0 | 5 | 4.2 | CN(C)CCc1cccc2c1cc(C(=O)c1ccccc1)n2S(=O)(=O)c1ccccc1 | 10.1021/jm010943m | |||
| 1524 | 2181 | 96 | None | -512 | 52 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm00384a001 | |||
| 197 | 2181 | 96 | None | -512 | 52 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm00384a001 | |||
| 3822 | 2181 | 96 | None | -512 | 52 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm00384a001 | |||
| 88 | 2181 | 96 | None | -512 | 52 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm00384a001 | |||
| CHEMBL51 | 2181 | 96 | None | -512 | 52 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm00384a001 | |||
| DB12465 | 2181 | 96 | None | -512 | 52 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm00384a001 | |||
| 10016864 | 204248 | 0 | None | -17 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 286 | 5 | 1 | 2 | 3.2 | CCCN(CCC)C1CCc2ccc3c(c2C1)CC(=O)N3 | 10.1021/jm00012a021 | |||
| CHEMBL71091 | 204248 | 0 | None | -17 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 286 | 5 | 1 | 2 | 3.2 | CCCN(CCC)C1CCc2ccc3c(c2C1)CC(=O)N3 | 10.1021/jm00012a021 | |||
| 10267412 | 204352 | 0 | None | -323 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 310 | 6 | 1 | 2 | 4.0 | CCCN(CC1CC1)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL71640 | 204352 | 0 | None | -323 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 310 | 6 | 1 | 2 | 4.0 | CCCN(CC1CC1)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| 4656 | 122960 | 7 | None | -39 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 355 | 1 | 2 | 1 | 2.8 | Clc1cc(I)cc(Cl)c1N=C1NCCN1 | 10.1016/j.bmcl.2004.06.085 | |||
| CHEMBL360803 | 122960 | 7 | None | -39 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 355 | 1 | 2 | 1 | 2.8 | Clc1cc(I)cc(Cl)c1N=C1NCCN1 | 10.1016/j.bmcl.2004.06.085 | |||
| 46905266 | 10174 | 0 | None | -7 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 419 | 5 | 2 | 3 | 4.2 | NC(=O)c1ccc2c(c1)CCO[C@@H]2CCN1CC=C(c2c[nH]c3c(F)cccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
| CHEMBL1159649 | 10174 | 0 | None | -7 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 419 | 5 | 2 | 3 | 4.2 | NC(=O)c1ccc2c(c1)CCO[C@@H]2CCN1CC=C(c2c[nH]c3c(F)cccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
| 10427962 | 20828 | 0 | None | -114 | 3 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 350 | 3 | 0 | 4 | 3.3 | c1ccc2c(c1)CCC2CN1CCN(c2cccc3c2OCCO3)CC1 | 10.1021/jm00020a020 | |||
| CHEMBL131011 | 20828 | 0 | None | -114 | 3 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 350 | 3 | 0 | 4 | 3.3 | c1ccc2c(c1)CCC2CN1CCN(c2cccc3c2OCCO3)CC1 | 10.1021/jm00020a020 | |||
| 10287730 | 3536 | 40 | None | -251 | 12 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 412 | 6 | 0 | 5 | 4.3 | Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2 | 10.1021/jm049039v | |||
| 77 | 3536 | 40 | None | -251 | 12 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 412 | 6 | 0 | 5 | 4.3 | Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2 | 10.1021/jm049039v | |||
| CHEMBL425190 | 3536 | 40 | None | -251 | 12 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 412 | 6 | 0 | 5 | 4.3 | Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2 | 10.1021/jm049039v | |||
| 11259254 | 125169 | 0 | None | -39 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 440 | 7 | 0 | 6 | 4.3 | Cc1ccc2c(OCCN3CCN(Cc4ccc(Cl)c([N+](=O)[O-])c4)CC3)cccc2n1 | 10.1021/jm049039v | |||
| CHEMBL364495 | 125169 | 0 | None | -39 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 440 | 7 | 0 | 6 | 4.3 | Cc1ccc2c(OCCN3CCN(Cc4ccc(Cl)c([N+](=O)[O-])c4)CC3)cccc2n1 | 10.1021/jm049039v | |||
| 44588720 | 184345 | 0 | None | -2 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 445 | 6 | 1 | 5 | 4.6 | Cc1ccc2c(OC(C)CN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.110 | |||
| CHEMBL484386 | 184345 | 0 | None | -2 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 445 | 6 | 1 | 5 | 4.6 | Cc1ccc2c(OC(C)CN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.110 | |||
| 10287730 | 3536 | 40 | None | -251 | 12 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 412 | 6 | 0 | 5 | 4.3 | Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2 | 10.1021/jm8001444 | |||
| 77 | 3536 | 40 | None | -251 | 12 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 412 | 6 | 0 | 5 | 4.3 | Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2 | 10.1021/jm8001444 | |||
| CHEMBL425190 | 3536 | 40 | None | -251 | 12 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 412 | 6 | 0 | 5 | 4.3 | Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2 | 10.1021/jm8001444 | |||
| 173 | 3262 | 95 | None | -2 | 23 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm990151g | |||
| 5011 | 3262 | 95 | None | -2 | 23 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm990151g | |||
| CHEMBL18772 | 3262 | 95 | None | -2 | 23 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm990151g | |||
| 10655811 | 204438 | 0 | None | -1 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 204 | 2 | 2 | 3 | 1.6 | Cc1ccc(CC2=NCCN2)c(C)c1O | 10.1021/jm970513p | |||
| CHEMBL72167 | 204438 | 0 | None | -1 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 204 | 2 | 2 | 3 | 1.6 | Cc1ccc(CC2=NCCN2)c(C)c1O | 10.1021/jm970513p | |||
| 44444557 | 154686 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 493 | 4 | 0 | 5 | 3.7 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(S(=O)(=O)c1cccc(Br)c1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
| CHEMBL399704 | 154686 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 493 | 4 | 0 | 5 | 3.7 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(S(=O)(=O)c1cccc(Br)c1)CC2 | 10.1016/j.bmcl.2007.09.067 | |||
| 6918603 | 207971 | 1 | None | -999 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 472 | 4 | 2 | 6 | 4.6 | Cc1c(S(=O)(=O)Nc2ccc3nccc(N4CCNCC4)c3c2)sc2ccc(Cl)cc12 | 10.1016/s0960-894x(01)00558-3 | |||
| CHEMBL97158 | 207971 | 1 | None | -999 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 472 | 4 | 2 | 6 | 4.6 | Cc1c(S(=O)(=O)Nc2ccc3nccc(N4CCNCC4)c3c2)sc2ccc(Cl)cc12 | 10.1016/s0960-894x(01)00558-3 | |||
| 10127209 | 68658 | 0 | None | 1 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 429 | 6 | 0 | 4 | 5.0 | Cc1ccc2c(OCCN3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)cccc2n1 | 10.1021/jm049039v | |||
| CHEMBL191980 | 68658 | 0 | None | 1 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 429 | 6 | 0 | 4 | 5.0 | Cc1ccc2c(OCCN3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)cccc2n1 | 10.1021/jm049039v | |||
| 44439165 | 145753 | 0 | None | -794 | 8 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 483 | 6 | 1 | 5 | 5.0 | Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(Cl)cc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
| CHEMBL391661 | 145753 | 0 | None | -794 | 8 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 483 | 6 | 1 | 5 | 5.0 | Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(Cl)cc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
| CHEMBL4576555 | 214017 | 5 | None | -2 | 19 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | None | None | None | CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1 | 10.6019/CHEMBL4507307 | |||||
| 10478367 | 71670 | 0 | None | 19 | 7 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 439 | 5 | 1 | 6 | 2.8 | COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL196370 | 71670 | 0 | None | 19 | 7 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 439 | 5 | 1 | 6 | 2.8 | COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL430500 | 71670 | 0 | None | 19 | 7 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 439 | 5 | 1 | 6 | 2.8 | COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| 10478367 | 71670 | 0 | None | 19 | 7 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 439 | 5 | 1 | 6 | 2.8 | COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
| CHEMBL196370 | 71670 | 0 | None | 19 | 7 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 439 | 5 | 1 | 6 | 2.8 | COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
| CHEMBL430500 | 71670 | 0 | None | 19 | 7 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 439 | 5 | 1 | 6 | 2.8 | COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
| 10664203 | 5483 | 0 | None | 31 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 330 | 10 | 2 | 2 | 5.4 | CC(C)(C)CCCCCCCOc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
| CHEMBL107617 | 5483 | 0 | None | 31 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 330 | 10 | 2 | 2 | 5.4 | CC(C)(C)CCCCCCCOc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
| 59636753 | 126215 | 0 | None | - | 1 | Chinese hamster | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 420 | 6 | 0 | 6 | 3.1 | CC(=O)c1ccc(CCN2CCN(c3cccc4cc(C(=O)N(C)C)oc34)CC2)nc1 | nan | |||
| CHEMBL3650036 | 126215 | 0 | None | - | 1 | Chinese hamster | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 420 | 6 | 0 | 6 | 3.1 | CC(=O)c1ccc(CCN2CCN(c3cccc4cc(C(=O)N(C)C)oc34)CC2)nc1 | nan | |||
| 44351692 | 19456 | 6 | None | -2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 242 | 2 | 1 | 3 | 2.3 | COc1ccc2ccc(N3CCNCC3)cc2c1 | 10.1021/jm9703552 | |||
| CHEMBL129661 | 19456 | 6 | None | -2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 242 | 2 | 1 | 3 | 2.3 | COc1ccc2ccc(N3CCNCC3)cc2c1 | 10.1021/jm9703552 | |||
| 44279889 | 103194 | 0 | None | -1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 510 | 7 | 0 | 6 | 5.0 | CN1CCN(c2cccc3ccc(OCCOc4ccc5cccc(N6CCN(C)CC6)c5c4)cc23)CC1 | 10.1016/s0960-894x(98)00222-4 | |||
| CHEMBL30831 | 103194 | 0 | None | -1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 510 | 7 | 0 | 6 | 5.0 | CN1CCN(c2cccc3ccc(OCCOc4ccc5cccc(N6CCN(C)CC6)c5c4)cc23)CC1 | 10.1016/s0960-894x(98)00222-4 | |||
| 1043 | 1582 | 14 | None | -29 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/j.bmcl.2011.09.046 | |||
| 149 | 1582 | 14 | None | -29 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/j.bmcl.2011.09.046 | |||
| 8223 | 1582 | 14 | None | -29 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/j.bmcl.2011.09.046 | |||
| CHEMBL442 | 1582 | 14 | None | -29 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/j.bmcl.2011.09.046 | |||
| DB00696 | 1582 | 14 | None | -29 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/j.bmcl.2011.09.046 | |||
| 49848635 | 125687 | 3 | None | - | 1 | Chinese hamster | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 378 | 5 | 0 | 5 | 2.9 | CN(C)C(=O)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| CHEMBL3647269 | 125687 | 3 | None | - | 1 | Chinese hamster | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 378 | 5 | 0 | 5 | 2.9 | CN(C)C(=O)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| 115 | 3791 | 80 | None | 1 | 27 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 10.1021/jm00125a020 | |||
| 4296 | 3791 | 80 | None | 1 | 27 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 10.1021/jm00125a020 | |||
| CHEMBL274866 | 3791 | 80 | None | 1 | 27 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 10.1021/jm00125a020 | |||
| 10251722 | 11377 | 0 | None | 20 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 423 | 4 | 1 | 5 | 3.1 | COc1ccc(NC(=O)N2CCN(c3ccccc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL105970 | 11377 | 0 | None | 20 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 423 | 4 | 1 | 5 | 3.1 | COc1ccc(NC(=O)N2CCN(c3ccccc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL1179958 | 11377 | 0 | None | 20 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 423 | 4 | 1 | 5 | 3.1 | COc1ccc(NC(=O)N2CCN(c3ccccc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| 9928474 | 9333 | 0 | None | 6 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 316 | 9 | 2 | 2 | 5.0 | CC(C)(C)CCCCCCOc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
| CHEMBL111150 | 9333 | 0 | None | 6 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 316 | 9 | 2 | 2 | 5.0 | CC(C)(C)CCCCCCOc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
| 59636733 | 125702 | 0 | None | - | 1 | Chinese hamster | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 470 | 8 | 1 | 6 | 4.1 | COc1cccc(CNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)c1 | nan | |||
| CHEMBL3647284 | 125702 | 0 | None | - | 1 | Chinese hamster | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 470 | 8 | 1 | 6 | 4.1 | COc1cccc(CNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)c1 | nan | |||
| 44342785 | 9835 | 0 | None | -5 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 460 | 5 | 2 | 3 | 5.3 | COc1ccc(NC(=S)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1 | 10.1016/s0960-894x(03)00779-0 | |||
| CHEMBL113994 | 9835 | 0 | None | -5 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 460 | 5 | 2 | 3 | 5.3 | COc1ccc(NC(=S)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1 | 10.1016/s0960-894x(03)00779-0 | |||
| 59636730 | 126217 | 0 | None | - | 1 | Chinese hamster | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 420 | 6 | 0 | 6 | 3.0 | COc1cccc(CCN2CCN(c3cccc4cc(C(=O)N5CCC5)oc34)CC2)n1 | nan | |||
| CHEMBL3650038 | 126217 | 0 | None | - | 1 | Chinese hamster | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 420 | 6 | 0 | 6 | 3.0 | COc1cccc(CCN2CCN(c3cccc4cc(C(=O)N5CCC5)oc34)CC2)n1 | nan | |||
| 5 | 139 | 72 | None | -13 | 54 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00014a021 | |||
| 5202 | 139 | 72 | None | -13 | 54 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00014a021 | |||
| CHEMBL39 | 139 | 72 | None | -13 | 54 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00014a021 | |||
| DB08839 | 139 | 72 | None | -13 | 54 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00014a021 | |||
| 44402883 | 72017 | 0 | None | 12 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 481 | 3 | 0 | 5 | 4.9 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Oc1cccc(C(F)(F)F)c1F)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| CHEMBL197505 | 72017 | 0 | None | 12 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 481 | 3 | 0 | 5 | 4.9 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Oc1cccc(C(F)(F)F)c1F)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| 44402882 | 133009 | 0 | None | 19 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 496 | 3 | 1 | 4 | 5.5 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Nc1cccc(C(F)(F)F)c1Cl)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| CHEMBL370214 | 133009 | 0 | None | 19 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 496 | 3 | 1 | 4 | 5.5 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Nc1cccc(C(F)(F)F)c1Cl)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| 44402884 | 135292 | 0 | None | 10 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 497 | 3 | 0 | 5 | 5.5 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Oc1cccc(C(F)(F)F)c1Cl)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| CHEMBL372731 | 135292 | 0 | None | 10 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 497 | 3 | 0 | 5 | 5.5 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Oc1cccc(C(F)(F)F)c1Cl)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| 10791443 | 77194 | 0 | None | 1 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 497 | 7 | 1 | 7 | 5.0 | Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc5c(c4)N(CCN(C)C)CCO5)cc3)c(C)c2)no1 | 10.1021/jm970457s | |||
| CHEMBL20791 | 77194 | 0 | None | 1 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 497 | 7 | 1 | 7 | 5.0 | Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc5c(c4)N(CCN(C)C)CCO5)cc3)c(C)c2)no1 | 10.1021/jm970457s | |||
| 10624768 | 99398 | 0 | None | 1 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 485 | 9 | 2 | 7 | 5.3 | COc1ccc(NC(=O)c2ccc(-c3ccc(-c4noc(C)n4)cc3C)cc2)cc1NCCN(C)C | 10.1021/jm970457s | |||
| CHEMBL282693 | 99398 | 0 | None | 1 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 485 | 9 | 2 | 7 | 5.3 | COc1ccc(NC(=O)c2ccc(-c3ccc(-c4noc(C)n4)cc3C)cc2)cc1NCCN(C)C | 10.1021/jm970457s | |||
| 11328382 | 91983 | 0 | None | -3 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 449 | 6 | 1 | 5 | 4.3 | Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
| CHEMBL241503 | 91983 | 0 | None | -3 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 449 | 6 | 1 | 5 | 4.3 | Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
| 49850874 | 56462 | 0 | None | -7 | 9 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 450 | 6 | 1 | 4 | 5.2 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccccc5)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| CHEMBL1632210 | 56462 | 0 | None | -7 | 9 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 450 | 6 | 1 | 4 | 5.2 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccccc5)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| 10477223 | 185017 | 0 | None | -12 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 420 | 4 | 1 | 5 | 3.4 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cc(F)cc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
| CHEMBL485491 | 185017 | 0 | None | -12 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 420 | 4 | 1 | 5 | 3.4 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cc(F)cc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
| 44404253 | 135279 | 0 | None | -1 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 477 | 4 | 1 | 7 | 3.5 | CCc1c(C(=O)N2CCc3cc4ccnc(N5CCNCC5)c4cc32)cnn1-c1ccc(C#N)cc1 | 10.1016/j.bmcl.2005.06.042 | |||
| CHEMBL372651 | 135279 | 0 | None | -1 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 477 | 4 | 1 | 7 | 3.5 | CCc1c(C(=O)N2CCc3cc4ccnc(N5CCNCC5)c4cc32)cnn1-c1ccc(C#N)cc1 | 10.1016/j.bmcl.2005.06.042 | |||
| 5 | 139 | 72 | None | -13 | 54 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm990151g | |||
| 5202 | 139 | 72 | None | -13 | 54 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm990151g | |||
| CHEMBL39 | 139 | 72 | None | -13 | 54 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm990151g | |||
| DB08839 | 139 | 72 | None | -13 | 54 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm990151g | |||
| 44279550 | 99805 | 0 | None | -2 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 650 | 8 | 0 | 8 | 3.6 | CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(C(=O)COc5ccc6cccc(N7CCN(C)CC7)c6c5)CC4)cc23)CC1 | 10.1016/s0960-894x(98)00222-4 | |||
| CHEMBL285402 | 99805 | 0 | None | -2 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 650 | 8 | 0 | 8 | 3.6 | CN1CCN(c2cccc3ccc(OCC(=O)N4CCN(C(=O)COc5ccc6cccc(N7CCN(C)CC7)c6c5)CC4)cc23)CC1 | 10.1016/s0960-894x(98)00222-4 | |||
| 11827039 | 207976 | 1 | None | 6 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 487 | 6 | 1 | 6 | 3.8 | Cn1nncc1-c1ccc2c(c1)c(C1CCN(CCN3CCNC3=O)CC1)cn2-c1ccc(F)cc1 | 10.1021/jm020938y | |||
| CHEMBL97184 | 207976 | 1 | None | 6 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 487 | 6 | 1 | 6 | 3.8 | Cn1nncc1-c1ccc2c(c1)c(C1CCN(CCN3CCNC3=O)CC1)cn2-c1ccc(F)cc1 | 10.1021/jm020938y | |||
| 11038248 | 111475 | 0 | None | 1 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 487 | 6 | 1 | 6 | 3.8 | Cn1cnnc1-c1ccc2c(c1)c(C1CCN(CCN3CCNC3=O)CC1)cn2-c1ccc(F)cc1 | 10.1021/jm020938y | |||
| CHEMBL327662 | 111475 | 0 | None | 1 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 487 | 6 | 1 | 6 | 3.8 | Cn1cnnc1-c1ccc2c(c1)c(C1CCN(CCN3CCNC3=O)CC1)cn2-c1ccc(F)cc1 | 10.1021/jm020938y | |||
| 11038263 | 112794 | 0 | None | -1 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 488 | 6 | 1 | 7 | 3.2 | Cn1nnnc1-c1ccc2c(c1)c(C1CCN(CCN3CCNC3=O)CC1)cn2-c1ccc(F)cc1 | 10.1021/jm020938y | |||
| CHEMBL330603 | 112794 | 0 | None | -1 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 488 | 6 | 1 | 7 | 3.2 | Cn1nnnc1-c1ccc2c(c1)c(C1CCN(CCN3CCNC3=O)CC1)cn2-c1ccc(F)cc1 | 10.1021/jm020938y | |||
| 10060289 | 60315 | 1 | None | -13 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 242 | 2 | 1 | 2 | 2.4 | CN(C)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL1744040 | 60315 | 1 | None | -13 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 242 | 2 | 1 | 2 | 2.4 | CN(C)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| 59636773 | 126216 | 0 | None | - | 1 | Chinese hamster | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 435 | 6 | 1 | 6 | 2.9 | CC(=O)Nc1ccc(CCN2CCN(c3cccc4cc(C(=O)N(C)C)oc34)CC2)nc1 | nan | |||
| CHEMBL3650037 | 126216 | 0 | None | - | 1 | Chinese hamster | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 435 | 6 | 1 | 6 | 2.9 | CC(=O)Nc1ccc(CCN2CCN(c3cccc4cc(C(=O)N(C)C)oc34)CC2)nc1 | nan | |||
| 10310103 | 107312 | 0 | None | -51 | 8 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 425 | 5 | 0 | 5 | 5.3 | N#CCCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4ncccn4)cc23)CC1 | 10.1021/jm020938y | |||
| CHEMBL317333 | 107312 | 0 | None | -51 | 8 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 425 | 5 | 0 | 5 | 5.3 | N#CCCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4ncccn4)cc23)CC1 | 10.1021/jm020938y | |||
| 44460826 | 170428 | 0 | None | -5 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 439 | 5 | 1 | 5 | 4.4 | NC(=O)c1ccc2c(c1)CCOC2CCN1CCC(c2nsc3cc(F)ccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
| CHEMBL444843 | 170428 | 0 | None | -5 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 439 | 5 | 1 | 5 | 4.4 | NC(=O)c1ccc2c(c1)CCOC2CCN1CCC(c2nsc3cc(F)ccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
| 44310169 | 204357 | 0 | None | -26 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 264 | 5 | 1 | 2 | 3.4 | CCCN(CCC)C1CCc2c(ccc(F)c2N)C1 | 10.1021/jm00012a021 | |||
| CHEMBL71676 | 204357 | 0 | None | -26 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 264 | 5 | 1 | 2 | 3.4 | CCCN(CCC)C1CCc2c(ccc(F)c2N)C1 | 10.1021/jm00012a021 | |||
| 9802187 | 205848 | 0 | None | -51 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 419 | 5 | 2 | 3 | 4.2 | NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2c[nH]c3cc(F)ccc23)CC1 | 10.1016/j.bmcl.2007.03.101 | |||
| CHEMBL83617 | 205848 | 0 | None | -51 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 419 | 5 | 2 | 3 | 4.2 | NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2c[nH]c3cc(F)ccc23)CC1 | 10.1016/j.bmcl.2007.03.101 | |||
| 137646281 | 157806 | 0 | None | -4677 | 17 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 423 | 8 | 0 | 7 | 3.8 | COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1 | 10.1021/acs.jmedchem.9b00412 | |||
| CHEMBL4083252 | 157806 | 0 | None | -4677 | 17 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 423 | 8 | 0 | 7 | 3.8 | COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1 | 10.1021/acs.jmedchem.9b00412 | |||
| 10385009 | 20496 | 0 | None | -331 | 2 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 378 | 5 | 0 | 4 | 4.1 | c1ccc2c(c1)CCC2CCCN1CCN(c2cccc3c2OCCO3)CC1 | 10.1021/jm00020a020 | |||
| CHEMBL130734 | 20496 | 0 | None | -331 | 2 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 378 | 5 | 0 | 4 | 4.1 | c1ccc2c(c1)CCC2CCCN1CCN(c2cccc3c2OCCO3)CC1 | 10.1021/jm00020a020 | |||
| 164 | 1460 | 19 | None | -89 | 10 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 209 | 4 | 1 | 3 | 1.9 | COc1cc(C)c(cc1CC(N)C)OC | 10.1021/jm00399a031 | |||
| 85875 | 1460 | 19 | None | -89 | 10 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 209 | 4 | 1 | 3 | 1.9 | COc1cc(C)c(cc1CC(N)C)OC | 10.1021/jm00399a031 | |||
| CHEMBL8600 | 1460 | 19 | None | -89 | 10 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 209 | 4 | 1 | 3 | 1.9 | COc1cc(C)c(cc1CC(N)C)OC | 10.1021/jm00399a031 | |||
| DB01528 | 1460 | 19 | None | -89 | 10 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 209 | 4 | 1 | 3 | 1.9 | COc1cc(C)c(cc1CC(N)C)OC | 10.1021/jm00399a031 | |||
| 9827354 | 112590 | 0 | None | -5 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 501 | 7 | 1 | 6 | 4.3 | CCn1ncc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | |||
| CHEMBL330171 | 112590 | 0 | None | -5 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 501 | 7 | 1 | 6 | 4.3 | CCn1ncc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | |||
| 173 | 3262 | 95 | None | -2 | 23 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm00014a021 | |||
| 5011 | 3262 | 95 | None | -2 | 23 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm00014a021 | |||
| CHEMBL18772 | 3262 | 95 | None | -2 | 23 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm00014a021 | |||
| 10640199 | 8995 | 0 | None | 3 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 330 | 13 | 2 | 2 | 5.6 | CCCCCCCCCCCOc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
| CHEMBL109839 | 8995 | 0 | None | 3 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 330 | 13 | 2 | 2 | 5.6 | CCCCCCCCCCCOc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
| 44431536 | 87321 | 0 | None | -23 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 454 | 5 | 1 | 5 | 4.0 | C[C@H]1CN(c2cccc3cc(C#N)ccc23)CCN1CC[C@@H]1OCCc2cc(C(N)=O)ccc21 | 10.1016/j.bmcl.2007.03.101 | |||
| CHEMBL233210 | 87321 | 0 | None | -23 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 454 | 5 | 1 | 5 | 4.0 | C[C@H]1CN(c2cccc3cc(C#N)ccc23)CCN1CC[C@@H]1OCCc2cc(C(N)=O)ccc21 | 10.1016/j.bmcl.2007.03.101 | |||
| 2735875 | 98483 | 92 | None | 1 | 2 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 187 | 1 | 1 | 3 | 1.0 | N#Cc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
| CHEMBL275943 | 98483 | 92 | None | 1 | 2 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 187 | 1 | 1 | 3 | 1.0 | N#Cc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
| 10870264 | 204348 | 1 | None | -389 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 298 | 6 | 1 | 2 | 4.0 | CCCN(CCC)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL71625 | 204348 | 1 | None | -389 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 298 | 6 | 1 | 2 | 4.0 | CCCN(CCC)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL5074880 | 214339 | 0 | None | -21 | 9 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | None | None | None | CCNCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
| 44461297 | 169266 | 0 | None | -8 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 420 | 5 | 2 | 4 | 3.6 | NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2[nH]nc3cc(F)ccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
| CHEMBL441259 | 169266 | 0 | None | -8 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 420 | 5 | 2 | 4 | 3.6 | NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2[nH]nc3cc(F)ccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
| 44461425 | 205859 | 0 | None | -7 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 430 | 5 | 1 | 3 | 4.9 | NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2cccc3ccc(F)cc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
| CHEMBL83732 | 205859 | 0 | None | -7 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 430 | 5 | 1 | 3 | 4.9 | NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2cccc3ccc(F)cc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
| 9997154 | 21063 | 0 | None | -120 | 2 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 336 | 3 | 0 | 4 | 2.9 | c1ccc2c(c1)CC2CN1CCN(c2cccc3c2OCCO3)CC1 | 10.1021/jm00020a020 | |||
| CHEMBL131198 | 21063 | 0 | None | -120 | 2 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 336 | 3 | 0 | 4 | 2.9 | c1ccc2c(c1)CC2CN1CCN(c2cccc3c2OCCO3)CC1 | 10.1021/jm00020a020 | |||
| 899057 | 60323 | 7 | None | - | 1 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 204 | 3 | 2 | 2 | 2.1 | COc1ccc2c(C[C@@H](C)N)c[nH]c2c1 | 10.1021/jm00402a026 | |||
| CHEMBL1744073 | 60323 | 7 | None | - | 1 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 204 | 3 | 2 | 2 | 2.1 | COc1ccc2c(C[C@@H](C)N)c[nH]c2c1 | 10.1021/jm00402a026 | |||
| 3117 | 207841 | 103 | None | -3 | 16 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 296 | 4 | 0 | 4 | 3.6 | CCN(CC)C(=S)SSC(=S)N(CC)CC | nan | |||
| CHEMBL964 | 207841 | 103 | None | -3 | 16 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 296 | 4 | 0 | 4 | 3.6 | CCN(CC)C(=S)SSC(=S)N(CC)CC | nan | |||
| 10424220 | 102866 | 0 | None | -151 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 288 | 5 | 1 | 1 | 4.3 | CCCN(CCC)C1CCc2cc(F)c3[nH]ccc3c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL305743 | 102866 | 0 | None | -151 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 288 | 5 | 1 | 1 | 4.3 | CCCN(CCC)C1CCc2cc(F)c3[nH]ccc3c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL4576555 | 214017 | 5 | None | -2 | 19 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | None | None | None | CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1 | 10.6019/CHEMBL4507307 | |||||
| 44582676 | 189779 | 0 | None | -16 | 17 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 403 | 9 | 0 | 4 | 4.3 | COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | |||
| CHEMBL516088 | 189779 | 0 | None | -16 | 17 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 403 | 9 | 0 | 4 | 4.3 | COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | |||
| 11778645 | 60316 | 0 | None | -60 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 284 | 5 | 1 | 1 | 4.4 | CCCN(CC(C)C)[C@@H]1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL1744041 | 60316 | 0 | None | -60 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 284 | 5 | 1 | 1 | 4.4 | CCCN(CC(C)C)[C@@H]1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
| 2543 | 3707 | 68 | None | -3 | 32 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9604890 | |||
| 5358 | 3707 | 68 | None | -3 | 32 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9604890 | |||
| 54 | 3707 | 68 | None | -3 | 32 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9604890 | |||
| CHEMBL128 | 3707 | 68 | None | -3 | 32 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9604890 | |||
| DB00669 | 3707 | 68 | None | -3 | 32 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9604890 | |||
| 10710400 | 9186 | 0 | None | 2 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 314 | 8 | 2 | 2 | 4.8 | NCCc1c[nH]c2ccc(OCCCCC3CCCCC3)cc12 | 10.1021/jm950498t | |||
| CHEMBL110318 | 9186 | 0 | None | 2 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 314 | 8 | 2 | 2 | 4.8 | NCCc1c[nH]c2ccc(OCCCCC3CCCCC3)cc12 | 10.1021/jm950498t | |||
| 10786335 | 12060 | 0 | None | 63 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 385 | 5 | 1 | 4 | 3.9 | COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1C#CCN(C)C | 10.1021/jm9702948 | |||
| CHEMBL118360 | 12060 | 0 | None | 63 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 385 | 5 | 1 | 4 | 3.9 | COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1C#CCN(C)C | 10.1021/jm9702948 | |||
| 10917953 | 207988 | 0 | None | -630 | 9 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 489 | 6 | 0 | 8 | 3.6 | Cn1nnc(-c2ccc3c(c2)c(C2CCN(CCN4CCOC4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | |||
| CHEMBL97242 | 207988 | 0 | None | -630 | 9 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 489 | 6 | 0 | 8 | 3.6 | Cn1nnc(-c2ccc3c(c2)c(C2CCN(CCN4CCOC4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | |||
| 26987 | 949 | 33 | None | -138 | 21 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | nan | |||
| 6063 | 949 | 33 | None | -138 | 21 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | nan | |||
| 671 | 949 | 33 | None | -138 | 21 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | nan | |||
| CHEMBL1626 | 949 | 33 | None | -138 | 21 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | nan | |||
| DB00283 | 949 | 33 | None | -138 | 21 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | nan | |||
| 24841480 | 183899 | 0 | None | -1096 | 20 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 340 | 3 | 0 | 4 | 4.5 | O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21 | 10.1016/j.bmcl.2013.04.082 | |||
| CHEMBL481153 | 183899 | 0 | None | -1096 | 20 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 340 | 3 | 0 | 4 | 4.5 | O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21 | 10.1016/j.bmcl.2013.04.082 | |||
| 6918542 | 204924 | 24 | None | -2238 | 10 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 358 | 6 | 0 | 5 | 3.0 | COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1 | 10.1021/jm010943m | |||
| CHEMBL76237 | 204924 | 24 | None | -2238 | 10 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 358 | 6 | 0 | 5 | 3.0 | COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1 | 10.1021/jm010943m | |||
| 11743042 | 204050 | 0 | None | -117 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 423 | 8 | 1 | 3 | 4.7 | CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL69943 | 204050 | 0 | None | -117 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 423 | 8 | 1 | 3 | 4.7 | CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
| 10400189 | 105655 | 0 | None | -229 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 256 | 4 | 2 | 2 | 2.8 | CCCNC1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL312525 | 105655 | 0 | None | -229 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 256 | 4 | 2 | 2 | 2.8 | CCCNC1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| 10468376 | 102086 | 1 | None | -512 | 5 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 270 | 5 | 1 | 1 | 4.1 | CCCN(CCC)[C@H]1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL302171 | 102086 | 1 | None | -512 | 5 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 270 | 5 | 1 | 1 | 4.1 | CCCN(CCC)[C@H]1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a021 | |||
| 10468376 | 102086 | 1 | None | -512 | 5 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 270 | 5 | 1 | 1 | 4.1 | CCCN(CCC)[C@H]1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL302171 | 102086 | 1 | None | -512 | 5 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 270 | 5 | 1 | 1 | 4.1 | CCCN(CCC)[C@H]1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
| 11948707 | 166167 | 0 | None | -562 | 13 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 373 | 7 | 0 | 8 | 0.6 | COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1 | 10.1016/j.bmcl.2006.01.052 | |||
| CHEMBL426317 | 166167 | 0 | None | -562 | 13 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 373 | 7 | 0 | 8 | 0.6 | COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1 | 10.1016/j.bmcl.2006.01.052 | |||
| 14547414 | 102284 | 1 | None | -15 | 5 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 214 | 1 | 1 | 1 | 2.6 | CN(C)[C@@H]1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL303339 | 102284 | 1 | None | -15 | 5 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 214 | 1 | 1 | 1 | 2.6 | CN(C)[C@@H]1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
| 10245352 | 204233 | 0 | None | -67 | 5 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 318 | 6 | 2 | 1 | 4.5 | c1ccc(CCCNCC2CCc3ccc4[nH]ccc4c3C2)cc1 | 10.1021/jm00012a022 | |||
| CHEMBL70980 | 204233 | 0 | None | -67 | 5 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 318 | 6 | 2 | 1 | 4.5 | c1ccc(CCCNCC2CCc3ccc4[nH]ccc4c3C2)cc1 | 10.1021/jm00012a022 | |||
| 25060119 | 104315 | 0 | None | -32359 | 7 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 493 | 7 | 1 | 5 | 6.1 | COc1ccc(CNC(=O)c2cc(-c3cc(Cl)cc(Cl)c3)cnc2-c2cccnc2)cc1OC | 10.1016/j.bmcl.2013.10.045 | |||
| CHEMBL3099899 | 104315 | 0 | None | -32359 | 7 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 493 | 7 | 1 | 5 | 6.1 | COc1ccc(CNC(=O)c2cc(-c3cc(Cl)cc(Cl)c3)cnc2-c2cccnc2)cc1OC | 10.1016/j.bmcl.2013.10.045 | |||
| 10090960 | 21068 | 0 | None | -114 | 2 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 376 | 4 | 0 | 4 | 4.0 | C1=C(CCN2CCN(c3cccc4c3OCCO4)CC2)c2ccccc2CC1 | 10.1021/jm00020a020 | |||
| CHEMBL131200 | 21068 | 0 | None | -114 | 2 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 376 | 4 | 0 | 4 | 4.0 | C1=C(CCN2CCN(c3cccc4c3OCCO4)CC2)c2ccccc2CC1 | 10.1021/jm00020a020 | |||
| 10775682 | 203192 | 1 | None | 109 | 2 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 227 | 1 | 1 | 2 | 2.7 | COc1c2c(cc3ccccc13)CCC(N)C2 | 10.1016/S0960-894X(01)81009-X | |||
| CHEMBL64303 | 203192 | 1 | None | 109 | 2 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 227 | 1 | 1 | 2 | 2.7 | COc1c2c(cc3ccccc13)CCC(N)C2 | 10.1016/S0960-894X(01)81009-X | |||
| 11402988 | 59210 | 0 | None | -32 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 270 | 4 | 1 | 2 | 4.0 | CN(C)CCc1c[nH]c2ccc(-c3cccs3)cc12 | 10.1016/s0960-894x(00)00133-5 | |||
| CHEMBL170192 | 59210 | 0 | None | -32 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 270 | 4 | 1 | 2 | 4.0 | CN(C)CCc1c[nH]c2ccc(-c3cccs3)cc12 | 10.1016/s0960-894x(00)00133-5 | |||
| 10096890 | 110156 | 0 | None | -26 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 485 | 5 | 1 | 3 | 5.4 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(S(=O)(=O)c4cccc5ccccc45)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
| CHEMBL323666 | 110156 | 0 | None | -26 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 485 | 5 | 1 | 3 | 5.4 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(S(=O)(=O)c4cccc5ccccc45)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
| 2543 | 3707 | 68 | None | -17 | 32 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00044a001 | |||
| 5358 | 3707 | 68 | None | -17 | 32 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00044a001 | |||
| 54 | 3707 | 68 | None | -17 | 32 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00044a001 | |||
| CHEMBL128 | 3707 | 68 | None | -17 | 32 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00044a001 | |||
| DB00669 | 3707 | 68 | None | -17 | 32 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00044a001 | |||
| 2543 | 3707 | 68 | None | -3 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00018a020 | |||
| 5358 | 3707 | 68 | None | -3 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00018a020 | |||
| 54 | 3707 | 68 | None | -3 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00018a020 | |||
| CHEMBL128 | 3707 | 68 | None | -3 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00018a020 | |||
| DB00669 | 3707 | 68 | None | -3 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00018a020 | |||
| 10447948 | 100171 | 0 | None | 1 | 3 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 307 | 1 | 0 | 3 | 3.4 | CN1CCN(c2nc3ccccc3c3c2CC2CCC3C2)CC1 | 10.1021/jm970645i | |||
| CHEMBL287987 | 100171 | 0 | None | 1 | 3 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 307 | 1 | 0 | 3 | 3.4 | CN1CCN(c2nc3ccccc3c3c2CC2CCC3C2)CC1 | 10.1021/jm970645i | |||
| 9927441 | 207394 | 0 | None | -676 | 9 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 328 | 5 | 0 | 4 | 3.0 | CN(C)CCc1cn(S(=O)(=O)c2ccccc2)c2ccccc12 | 10.1021/jm010943m | |||
| CHEMBL93868 | 207394 | 0 | None | -676 | 9 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 328 | 5 | 0 | 4 | 3.0 | CN(C)CCc1cn(S(=O)(=O)c2ccccc2)c2ccccc12 | 10.1021/jm010943m | |||
| 9950390 | 66251 | 0 | None | -588 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2n[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc23)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| CHEMBL184597 | 66251 | 0 | None | -588 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2n[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc23)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| 76319310 | 106322 | 0 | None | -2 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 321 | 4 | 1 | 2 | 3.2 | CNC(C)COc1ccc(Br)cc1Br | 10.1007/s00044-009-9164-1 | |||
| CHEMBL2260928 | 106322 | 0 | None | -2 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 321 | 4 | 1 | 2 | 3.2 | CNC(C)COc1ccc(Br)cc1Br | 10.1007/s00044-009-9164-1 | |||
| CHEMBL3139131 | 106322 | 0 | None | -2 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 321 | 4 | 1 | 2 | 3.2 | CNC(C)COc1ccc(Br)cc1Br | 10.1007/s00044-009-9164-1 | |||
| 3251 | 4072 | 58 | None | -79 | 12 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 422 | 7 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 | 10.1021/jm1009956 | |||
| 5684 | 4072 | 58 | None | -79 | 12 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 422 | 7 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 | 10.1021/jm1009956 | |||
| 80 | 4072 | 58 | None | -79 | 12 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 422 | 7 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 | 10.1021/jm1009956 | |||
| CHEMBL31354 | 4072 | 58 | None | -79 | 12 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 422 | 7 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 | 10.1021/jm1009956 | |||
| 11792868 | 199187 | 0 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 360 | 4 | 1 | 6 | 0.7 | O=C(C1=Cc2cccc(OCC3CNCCO3)c2OC1)N1CCOCC1 | 10.1021/jm970806i | |||
| CHEMBL58961 | 199187 | 0 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 360 | 4 | 1 | 6 | 0.7 | O=C(C1=Cc2cccc(OCC3CNCCO3)c2OC1)N1CCOCC1 | 10.1021/jm970806i | |||
| 151 | 2416 | 44 | None | -89 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1021/jm030020m | |||
| 20 | 2416 | 44 | None | -89 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1021/jm030020m | |||
| 5311258 | 2416 | 44 | None | -89 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1021/jm030020m | |||
| CHEMBL101690 | 2416 | 44 | None | -89 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1021/jm030020m | |||
| 151 | 2416 | 44 | None | -89 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1016/j.bmcl.2004.09.079 | |||
| 20 | 2416 | 44 | None | -89 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1016/j.bmcl.2004.09.079 | |||
| 5311258 | 2416 | 44 | None | -89 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1016/j.bmcl.2004.09.079 | |||
| CHEMBL101690 | 2416 | 44 | None | -89 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1016/j.bmcl.2004.09.079 | |||
| 44395787 | 126783 | 7 | None | -588 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 352 | 3 | 1 | 4 | 3.7 | CN1CCC(n2ncc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| CHEMBL365405 | 126783 | 7 | None | -588 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 352 | 3 | 1 | 4 | 3.7 | CN1CCC(n2ncc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| 10475893 | 163931 | 0 | None | -20 | 5 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 396 | 8 | 1 | 2 | 5.9 | CCCN(CCCOc1cccc(Cl)c1)C1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL420748 | 163931 | 0 | None | -20 | 5 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 396 | 8 | 1 | 2 | 5.9 | CCCN(CCCOc1cccc(Cl)c1)C1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
| 132060770 | 162639 | 0 | None | -39 | 10 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 451 | 7 | 0 | 6 | 3.5 | CCOC(=O)CCN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1 | 10.1016/j.ejmech.2018.02.024 | |||
| CHEMBL4169689 | 162639 | 0 | None | -39 | 10 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 451 | 7 | 0 | 6 | 3.5 | CCOC(=O)CCN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1 | 10.1016/j.ejmech.2018.02.024 | |||
| 10691904 | 35620 | 0 | None | -6 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 392 | 9 | 1 | 4 | 4.1 | CCCN(CCC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
| CHEMBL143967 | 35620 | 0 | None | -6 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 392 | 9 | 1 | 4 | 4.1 | CCCN(CCC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
| 122187378 | 123026 | 0 | None | -8 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 455 | 5 | 0 | 5 | 5.6 | COc1cc2c3c(c1OCC1CC1)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4 | 10.1016/j.bmcl.2015.07.012 | |||
| CHEMBL3609143 | 123026 | 0 | None | -8 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 455 | 5 | 0 | 5 | 5.6 | COc1cc2c3c(c1OCC1CC1)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4 | 10.1016/j.bmcl.2015.07.012 | |||
| 76315631 | 106213 | 0 | None | -4 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 233 | 4 | 1 | 2 | 3.0 | CNC(C)COc1cccc(Cl)c1Cl | 10.1007/s00044-009-9164-1 | |||
| CHEMBL2260925 | 106213 | 0 | None | -4 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 233 | 4 | 1 | 2 | 3.0 | CNC(C)COc1cccc(Cl)c1Cl | 10.1007/s00044-009-9164-1 | |||
| CHEMBL3138773 | 106213 | 0 | None | -4 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 233 | 4 | 1 | 2 | 3.0 | CNC(C)COc1cccc(Cl)c1Cl | 10.1007/s00044-009-9164-1 | |||
| 10449461 | 204459 | 0 | None | -354 | 5 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 332 | 6 | 1 | 1 | 5.0 | CCCN(CCc1ccccc1)C1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL72285 | 204459 | 0 | None | -354 | 5 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 332 | 6 | 1 | 1 | 5.0 | CCCN(CCc1ccccc1)C1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
| 5 | 139 | 72 | None | -13 | 54 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00384a001 | |||
| 5202 | 139 | 72 | None | -13 | 54 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00384a001 | |||
| CHEMBL39 | 139 | 72 | None | -13 | 54 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00384a001 | |||
| DB08839 | 139 | 72 | None | -13 | 54 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00384a001 | |||
| 133 | 2496 | 52 | None | -40 | 42 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 10.1021/jm00384a001 | |||
| 1723 | 2496 | 52 | None | -40 | 42 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 10.1021/jm00384a001 | |||
| 28693 | 2496 | 52 | None | -40 | 42 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 10.1021/jm00384a001 | |||
| CHEMBL19215 | 2496 | 52 | None | -40 | 42 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 10.1021/jm00384a001 | |||
| DB13520 | 2496 | 52 | None | -40 | 42 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 10.1021/jm00384a001 | |||
| 11809037 | 5093 | 0 | None | -5 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 309 | 3 | 1 | 5 | 1.7 | CN1CCC(c2c[nH]c3ccc(OS(C)(=O)=O)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL105556 | 5093 | 0 | None | -5 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 309 | 3 | 1 | 5 | 1.7 | CN1CCC(c2c[nH]c3ccc(OS(C)(=O)=O)nc23)CC1 | 10.1021/jm030020m | |||
| 44443101 | 93959 | 0 | None | -12 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 536 | 9 | 0 | 6 | 4.7 | Cc1ccc2c(OCCN3CCN(Cc4ccc5c(c4)N(CCc4ccccc4)C(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2007.06.078 | |||
| CHEMBL248407 | 93959 | 0 | None | -12 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 536 | 9 | 0 | 6 | 4.7 | Cc1ccc2c(OCCN3CCN(Cc4ccc5c(c4)N(CCc4ccccc4)C(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2007.06.078 | |||
| 44443094 | 93971 | 0 | None | -25 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 460 | 7 | 0 | 6 | 3.5 | CCN1C(=O)COc2ccc(CN3CCN(CCOc4cccc5nc(C)ccc45)CC3)cc21 | 10.1016/j.bmcl.2007.06.078 | |||
| CHEMBL248458 | 93971 | 0 | None | -25 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 460 | 7 | 0 | 6 | 3.5 | CCN1C(=O)COc2ccc(CN3CCN(CCOc4cccc5nc(C)ccc45)CC3)cc21 | 10.1016/j.bmcl.2007.06.078 | |||
| 44588745 | 184982 | 0 | None | -3 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 417 | 5 | 1 | 5 | 4.0 | Cc1ccc2c(OC3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.110 | |||
| CHEMBL485427 | 184982 | 0 | None | -3 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 417 | 5 | 1 | 5 | 4.0 | Cc1ccc2c(OC3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.110 | |||
| 10151492 | 193382 | 0 | None | -100 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 446 | 8 | 2 | 4 | 5.0 | CCNC(=O)Nc1cccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm8001444 | |||
| CHEMBL525362 | 193382 | 0 | None | -100 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 446 | 8 | 2 | 4 | 5.0 | CCNC(=O)Nc1cccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm8001444 | |||
| 10778246 | 165440 | 0 | None | -1 | 3 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 267 | 1 | 0 | 5 | 1.6 | CN1CCN(c2nc3ncccc3n3cccc23)CC1 | 10.1021/jm990151g | |||
| CHEMBL423899 | 165440 | 0 | None | -1 | 3 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 267 | 1 | 0 | 5 | 1.6 | CN1CCN(c2nc3ncccc3n3cccc23)CC1 | 10.1021/jm990151g | |||
| 10802125 | 198071 | 1 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 272 | 3 | 1 | 5 | 1.4 | N#CC1=Cc2cccc(OCC3CNCCO3)c2OC1 | 10.1021/jm970806i | |||
| CHEMBL57423 | 198071 | 1 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 272 | 3 | 1 | 5 | 1.4 | N#CC1=Cc2cccc(OCC3CNCCO3)c2OC1 | 10.1021/jm970806i | |||
| CHEMBL5093342 | 215564 | 0 | None | -29 | 7 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | None | None | None | CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
| CHEMBL5095971 | 215564 | 0 | None | -29 | 7 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | None | None | None | CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
| 152 | 364 | 29 | None | -33 | 18 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 10.1021/jm950498t | |||
| 2107 | 364 | 29 | None | -33 | 18 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 10.1021/jm950498t | |||
| CHEMBL275854 | 364 | 29 | None | -33 | 18 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 10.1021/jm950498t | |||
| 10451312 | 20671 | 0 | None | -316 | 2 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 362 | 4 | 0 | 4 | 3.6 | C1=C(CCN2CCN(c3cccc4c3OCCO4)CC2)c2ccccc2C1 | 10.1021/jm00020a020 | |||
| CHEMBL130870 | 20671 | 0 | None | -316 | 2 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 362 | 4 | 0 | 4 | 3.6 | C1=C(CCN2CCN(c3cccc4c3OCCO4)CC2)c2ccccc2C1 | 10.1021/jm00020a020 | |||
| 10150658 | 68645 | 1 | None | -158 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 392 | 6 | 2 | 6 | 3.0 | Cc1ccc2c(OCCN3CCN(Cc4ccc(O)c(N)c4)CC3)cccc2n1 | 10.1021/jm049039v | |||
| CHEMBL191895 | 68645 | 1 | None | -158 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 392 | 6 | 2 | 6 | 3.0 | Cc1ccc2c(OCCN3CCN(Cc4ccc(O)c(N)c4)CC3)cccc2n1 | 10.1021/jm049039v | |||
| 10173169 | 68651 | 0 | None | -100 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 412 | 6 | 0 | 5 | 4.3 | Cc1ccc2c(OCCN3CCN(Cc4cccc5ncccc45)CC3)cccc2n1 | 10.1021/jm049039v | |||
| CHEMBL191921 | 68651 | 0 | None | -100 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 412 | 6 | 0 | 5 | 4.3 | Cc1ccc2c(OCCN3CCN(Cc4cccc5ncccc45)CC3)cccc2n1 | 10.1021/jm049039v | |||
| 11774585 | 69173 | 0 | None | -31 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 424 | 7 | 0 | 6 | 3.8 | Cc1ccc2c(OCCN3CCN(Cc4ccc(F)c([N+](=O)[O-])c4)CC3)cccc2n1 | 10.1021/jm049039v | |||
| CHEMBL192536 | 69173 | 0 | None | -31 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 424 | 7 | 0 | 6 | 3.8 | Cc1ccc2c(OCCN3CCN(Cc4ccc(F)c([N+](=O)[O-])c4)CC3)cccc2n1 | 10.1021/jm049039v | |||
| 24865538 | 187579 | 0 | None | -251 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 361 | 6 | 0 | 4 | 3.7 | Cc1ccc2c(OCCN3CCN(Cc4ccccc4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
| CHEMBL494631 | 187579 | 0 | None | -251 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 361 | 6 | 0 | 4 | 3.7 | Cc1ccc2c(OCCN3CCN(Cc4ccccc4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
| 10683189 | 119082 | 0 | None | 3 | 2 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 266 | 1 | 1 | 4 | 2.2 | Cc1cccc2nc(N3CCNCC3)c3cccn3c12 | 10.1021/jm990151g | |||
| CHEMBL342690 | 119082 | 0 | None | 3 | 2 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 266 | 1 | 1 | 4 | 2.2 | Cc1cccc2nc(N3CCNCC3)c3cccn3c12 | 10.1021/jm990151g | |||
| 9805456 | 207746 | 0 | None | -1995 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 486 | 4 | 2 | 6 | 5.0 | Cc1c(S(=O)(=O)Nc2ccc3nccc(N4CCN[C@@H](C)C4)c3c2)sc2ccc(Cl)cc12 | 10.1016/s0960-894x(01)00558-3 | |||
| CHEMBL95823 | 207746 | 0 | None | -1995 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 486 | 4 | 2 | 6 | 5.0 | Cc1c(S(=O)(=O)Nc2ccc3nccc(N4CCN[C@@H](C)C4)c3c2)sc2ccc(Cl)cc12 | 10.1016/s0960-894x(01)00558-3 | |||
| 1220 | 187 | 55 | None | -7413 | 44 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1021/jm00027a013 | |||
| 31 | 187 | 55 | None | -7413 | 44 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1021/jm00027a013 | |||
| 7 | 187 | 55 | None | -7413 | 44 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1021/jm00027a013 | |||
| CHEMBL56 | 187 | 55 | None | -7413 | 44 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1021/jm00027a013 | |||
| 10402263 | 103199 | 1 | None | -18 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 295 | 5 | 1 | 2 | 4.0 | CCCN(CCC)[C@@H]1CCc2ccc3[nH]cc(C#N)c3c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL308347 | 103199 | 1 | None | -18 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 295 | 5 | 1 | 2 | 4.0 | CCCN(CCC)[C@@H]1CCc2ccc3[nH]cc(C#N)c3c2C1 | 10.1021/jm00012a021 | |||
| 44395832 | 123194 | 5 | None | -120 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 351 | 3 | 1 | 3 | 4.3 | CN1CCC(n2ccc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| CHEMBL361303 | 123194 | 5 | None | -120 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 351 | 3 | 1 | 3 | 4.3 | CN1CCC(n2ccc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| 10692095 | 204392 | 0 | None | -120 | 4 | Western lowland gorilla | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 395 | 6 | 1 | 5 | 2.6 | COc1ccc(N2CCN(CC[C@H]3OCCc4cc(C(N)=O)ccc43)CC2)cc1 | 10.1021/jm980137o | |||
| CHEMBL71907 | 204392 | 0 | None | -120 | 4 | Western lowland gorilla | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 395 | 6 | 1 | 5 | 2.6 | COc1ccc(N2CCN(CC[C@H]3OCCc4cc(C(N)=O)ccc43)CC2)cc1 | 10.1021/jm980137o | |||
| 10326069 | 39296 | 1 | None | -147 | 9 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 589 | 10 | 3 | 8 | 3.3 | CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 | 10.1021/jm980506g | |||
| CHEMBL147077 | 39296 | 1 | None | -147 | 9 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 589 | 10 | 3 | 8 | 3.3 | CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 | 10.1021/jm980506g | |||
| 14083209 | 63064 | 2 | None | - | 1 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 204 | 3 | 2 | 2 | 2.1 | COc1cccc2[nH]cc(C[C@H](C)N)c12 | 10.1021/jm00402a026 | |||
| CHEMBL1788280 | 63064 | 2 | None | - | 1 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 204 | 3 | 2 | 2 | 2.1 | COc1cccc2[nH]cc(C[C@H](C)N)c12 | 10.1021/jm00402a026 | |||
| 129503 | 161668 | 10 | None | -22 | 5 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 214 | 1 | 1 | 1 | 2.6 | CN(C)C1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL413105 | 161668 | 10 | None | -22 | 5 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 214 | 1 | 1 | 1 | 2.6 | CN(C)C1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
| 10872581 | 4929 | 0 | None | -34 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 379 | 4 | 2 | 5 | 3.5 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc([N+](=O)[O-])cc4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL104692 | 4929 | 0 | None | -34 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 379 | 4 | 2 | 5 | 3.5 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc([N+](=O)[O-])cc4)nc23)CC1 | 10.1021/jm030020m | |||
| 10445946 | 167863 | 4 | None | -53 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 272 | 2 | 2 | 3 | 2.3 | CC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| CHEMBL431041 | 167863 | 4 | None | -53 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 272 | 2 | 2 | 3 | 2.3 | CC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| 53248365 | 62086 | 0 | None | -281 | 7 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 554 | 6 | 1 | 5 | 2.9 | O=C(N(CCN1CCN(c2ccccc2O)CC1)c1ccccn1)C12C3C4C1C1C2C3C41I | 10.1021/jm1009956 | |||
| CHEMBL1774995 | 62086 | 0 | None | -281 | 7 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 554 | 6 | 1 | 5 | 2.9 | O=C(N(CCN1CCN(c2ccccc2O)CC1)c1ccccn1)C12C3C4C1C1C2C3C41I | 10.1021/jm1009956 | |||
| 16117279 | 60136 | 0 | None | -2754 | 7 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 398 | 5 | 3 | 5 | 3.7 | CC(C)c1ccc(S(=O)(=O)c2n[nH]c3ccc(NC4CCNCC4)cc23)cc1 | 10.1016/j.bmc.2010.10.033 | |||
| CHEMBL1642886 | 60136 | 0 | None | -2754 | 7 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 398 | 5 | 3 | 5 | 3.7 | CC(C)c1ccc(S(=O)(=O)c2n[nH]c3ccc(NC4CCNCC4)cc23)cc1 | 10.1016/j.bmc.2010.10.033 | |||
| CHEMBL1739606 | 60136 | 0 | None | -2754 | 7 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 398 | 5 | 3 | 5 | 3.7 | CC(C)c1ccc(S(=O)(=O)c2n[nH]c3ccc(NC4CCNCC4)cc23)cc1 | 10.1016/j.bmc.2010.10.033 | |||
| 28338386 | 106225 | 2 | None | -2 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 219 | 4 | 1 | 2 | 2.6 | CNCCOc1ccc(Cl)cc1Cl | 10.1007/s00044-009-9164-1 | |||
| CHEMBL2260921 | 106225 | 2 | None | -2 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 219 | 4 | 1 | 2 | 2.6 | CNCCOc1ccc(Cl)cc1Cl | 10.1007/s00044-009-9164-1 | |||
| CHEMBL3138811 | 106225 | 2 | None | -2 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 219 | 4 | 1 | 2 | 2.6 | CNCCOc1ccc(Cl)cc1Cl | 10.1007/s00044-009-9164-1 | |||
| 6604864 | 198818 | 1 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 346 | 5 | 1 | 6 | 1.2 | C1=C(CN2CCOCC2)COc2c1cccc2OC[C@@H]1CNCCO1 | 10.1021/jm970806i | |||
| CHEMBL1202783 | 198818 | 1 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 346 | 5 | 1 | 6 | 1.2 | C1=C(CN2CCOCC2)COc2c1cccc2OC[C@@H]1CNCCO1 | 10.1021/jm970806i | |||
| CHEMBL58353 | 198818 | 1 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 346 | 5 | 1 | 6 | 1.2 | C1=C(CN2CCOCC2)COc2c1cccc2OC[C@@H]1CNCCO1 | 10.1021/jm970806i | |||
| 10590370 | 161818 | 0 | None | -1 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 300 | 11 | 2 | 1 | 5.4 | CCCCCCCCCCc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
| CHEMBL414420 | 161818 | 0 | None | -1 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 300 | 11 | 2 | 1 | 5.4 | CCCCCCCCCCc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
| 9837108 | 204658 | 3 | None | -8 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 202 | 3 | 1 | 2 | 2.4 | CC(C)c1ccc(CC2=NCCN2)cc1 | 10.1021/jm970513p | |||
| CHEMBL73670 | 204658 | 3 | None | -8 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 202 | 3 | 1 | 2 | 2.4 | CC(C)c1ccc(CC2=NCCN2)cc1 | 10.1021/jm970513p | |||
| 11726413 | 102106 | 0 | None | -14 | 5 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 366 | 6 | 1 | 2 | 4.9 | CCCN(CCC)C1CCc2ccc3[nH]cc(C(=O)C(F)(F)F)c3c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL302263 | 102106 | 0 | None | -14 | 5 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 366 | 6 | 1 | 2 | 4.9 | CCCN(CCC)C1CCc2ccc3[nH]cc(C(=O)C(F)(F)F)c3c2C1 | 10.1021/jm00012a021 | |||
| 9848876 | 107445 | 0 | None | 1 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 501 | 7 | 1 | 6 | 4.3 | CCn1cc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)nn1 | 10.1021/jm020938y | |||
| CHEMBL318249 | 107445 | 0 | None | 1 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 501 | 7 | 1 | 6 | 4.3 | CCn1cc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)nn1 | 10.1021/jm020938y | |||
| 44403102 | 71732 | 0 | None | 12 | 6 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 477 | 4 | 1 | 5 | 3.8 | COc1ccc(NC(=O)N2CCN(c3ccc(C(F)(F)F)cc3)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
| CHEMBL196598 | 71732 | 0 | None | 12 | 6 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 477 | 4 | 1 | 5 | 3.8 | COc1ccc(NC(=O)N2CCN(c3ccc(C(F)(F)F)cc3)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
| 70529 | 207470 | 110 | None | 1 | 2 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 180 | 1 | 1 | 2 | 1.2 | Fc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
| CHEMBL9429 | 207470 | 110 | None | 1 | 2 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 180 | 1 | 1 | 2 | 1.2 | Fc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
| CHEMBL5090884 | 215577 | 0 | None | -4 | 7 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | None | None | None | CCCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
| CHEMBL5096072 | 215577 | 0 | None | -4 | 7 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | None | None | None | CCCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
| 59636748 | 126204 | 0 | None | - | 1 | Chinese hamster | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 458 | 7 | 1 | 7 | 3.4 | CC(NC(=O)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1)c1ccnn1C | nan | |||
| CHEMBL3650025 | 126204 | 0 | None | - | 1 | Chinese hamster | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 458 | 7 | 1 | 7 | 3.4 | CC(NC(=O)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1)c1ccnn1C | nan | |||
| 10063561 | 167801 | 1 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 303 | 1 | 1 | 4 | 3.5 | c1ccc2c(c1)nc(N1CCNCC1)c1oc3ccccc3c12 | 10.1021/jm00014a021 | |||
| CHEMBL430566 | 167801 | 1 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 303 | 1 | 1 | 4 | 3.5 | c1ccc2c(c1)nc(N1CCNCC1)c1oc3ccccc3c12 | 10.1021/jm00014a021 | |||
| 9802187 | 205848 | 0 | None | -51 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 419 | 5 | 2 | 3 | 4.2 | NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2c[nH]c3cc(F)ccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
| CHEMBL83617 | 205848 | 0 | None | -51 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 419 | 5 | 2 | 3 | 4.2 | NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2c[nH]c3cc(F)ccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
| 44431531 | 88025 | 0 | None | -60 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 447 | 5 | 1 | 4 | 4.3 | C[C@@H]1CN(c2cccc3cc(F)ccc23)CCN1CCC1OCCc2cc(C(N)=O)ccc21 | 10.1016/j.bmcl.2007.03.101 | |||
| CHEMBL234447 | 88025 | 0 | None | -60 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 447 | 5 | 1 | 4 | 4.3 | C[C@@H]1CN(c2cccc3cc(F)ccc23)CCN1CCC1OCCc2cc(C(N)=O)ccc21 | 10.1016/j.bmcl.2007.03.101 | |||
| 9802187 | 205848 | 0 | None | -51 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 419 | 5 | 2 | 3 | 4.2 | NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2c[nH]c3cc(F)ccc23)CC1 | 10.1021/jm058225d | |||
| CHEMBL83617 | 205848 | 0 | None | -51 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 419 | 5 | 2 | 3 | 4.2 | NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2c[nH]c3cc(F)ccc23)CC1 | 10.1021/jm058225d | |||
| 10775128 | 188731 | 3 | None | -2 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 216 | 4 | 1 | 1 | 2.8 | CCc1ccc2[nH]cc(CCN(C)C)c2c1 | 10.1016/s0960-894x(00)00322-x | |||
| CHEMBL50492 | 188731 | 3 | None | -2 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 216 | 4 | 1 | 1 | 2.8 | CCc1ccc2[nH]cc(CCN(C)C)c2c1 | 10.1016/s0960-894x(00)00322-x | |||
| 60820 | 4308 | 14 | None | -144543 | 13 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 421 | 6 | 0 | 4 | 4.4 | CC(C)Oc1ccccc1N1CCN(Cc2cccc(C(=O)N3CCCCC3)c2)CC1 | 10.1016/j.bmc.2008.02.091 | |||
| CHEMBL10085 | 4308 | 14 | None | -144543 | 13 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 421 | 6 | 0 | 4 | 4.4 | CC(C)Oc1ccccc1N1CCN(Cc2cccc(C(=O)N3CCCCC3)c2)CC1 | 10.1016/j.bmc.2008.02.091 | |||
| 60820 | 4308 | 14 | None | -144543 | 13 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 421 | 6 | 0 | 4 | 4.4 | CC(C)Oc1ccccc1N1CCN(Cc2cccc(C(=O)N3CCCCC3)c2)CC1 | 10.1021/jm00034a003 | |||
| CHEMBL10085 | 4308 | 14 | None | -144543 | 13 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 421 | 6 | 0 | 4 | 4.4 | CC(C)Oc1ccccc1N1CCN(Cc2cccc(C(=O)N3CCCCC3)c2)CC1 | 10.1021/jm00034a003 | |||
| 10891048 | 4811 | 0 | None | -13 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 273 | 2 | 2 | 4 | 1.7 | CC(=O)Nc1ncc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| CHEMBL104158 | 4811 | 0 | None | -13 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 273 | 2 | 2 | 4 | 1.7 | CC(=O)Nc1ncc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| 23533329 | 85113 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 493 | 9 | 2 | 7 | 3.0 | COc1cc(N(C)CCCN(C)C)c2[nH]c(C(=O)Nc3ccc(N4CCOCC4)cc3)cc(=O)c2c1 | 10.1016/j.bmc.2006.10.037 | |||
| CHEMBL224738 | 85113 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 493 | 9 | 2 | 7 | 3.0 | COc1cc(N(C)CCCN(C)C)c2[nH]c(C(=O)Nc3ccc(N4CCOCC4)cc3)cc(=O)c2c1 | 10.1016/j.bmc.2006.10.037 | |||
| 115 | 3791 | 80 | None | 1 | 27 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 10.1021/jm00145a017 | |||
| 4296 | 3791 | 80 | None | 1 | 27 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 10.1021/jm00145a017 | |||
| CHEMBL274866 | 3791 | 80 | None | 1 | 27 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 10.1021/jm00145a017 | |||
| 10342552 | 9936 | 0 | None | -9 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 428 | 4 | 2 | 2 | 5.4 | Cc1ccc(NC(=O)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1 | 10.1016/s0960-894x(03)00779-0 | |||
| CHEMBL114571 | 9936 | 0 | None | -9 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 428 | 4 | 2 | 2 | 5.4 | Cc1ccc(NC(=O)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1 | 10.1016/s0960-894x(03)00779-0 | |||
| 10613373 | 111305 | 1 | None | -1 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 288 | 10 | 2 | 2 | 4.4 | CCCCCCCCOc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
| CHEMBL326667 | 111305 | 1 | None | -1 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 288 | 10 | 2 | 2 | 4.4 | CCCCCCCCOc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
| 1043 | 1582 | 14 | None | -29 | 28 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/j.bmcl.2013.12.024 | |||
| 149 | 1582 | 14 | None | -29 | 28 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/j.bmcl.2013.12.024 | |||
| 8223 | 1582 | 14 | None | -29 | 28 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/j.bmcl.2013.12.024 | |||
| CHEMBL442 | 1582 | 14 | None | -29 | 28 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/j.bmcl.2013.12.024 | |||
| DB00696 | 1582 | 14 | None | -29 | 28 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/j.bmcl.2013.12.024 | |||
| 1043 | 1582 | 14 | None | -29 | 28 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/j.bmcl.2013.12.024 | |||
| 149 | 1582 | 14 | None | -29 | 28 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/j.bmcl.2013.12.024 | |||
| 8223 | 1582 | 14 | None | -29 | 28 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/j.bmcl.2013.12.024 | |||
| CHEMBL442 | 1582 | 14 | None | -29 | 28 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/j.bmcl.2013.12.024 | |||
| DB00696 | 1582 | 14 | None | -29 | 28 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/j.bmcl.2013.12.024 | |||
| 44402877 | 71131 | 0 | None | 31 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 520 | 4 | 0 | 5 | 6.0 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)c1ccc(-c3cccc(C)n3)c3ccccc13)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| CHEMBL195497 | 71131 | 0 | None | 31 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 520 | 4 | 0 | 5 | 6.0 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)c1ccc(-c3cccc(C)n3)c3ccccc13)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| 44402880 | 71233 | 0 | None | 63 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 479 | 4 | 0 | 4 | 4.5 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Cc1cccc(F)c1C(F)(F)F)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| CHEMBL195651 | 71233 | 0 | None | 63 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 479 | 4 | 0 | 4 | 4.5 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Cc1cccc(F)c1C(F)(F)F)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| 11591924 | 71758 | 3 | None | 79 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 537 | 5 | 1 | 7 | 5.4 | COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(C(=O)c1ccc(-c3ccc(-c4noc(C)n4)cc3C)cc1)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| CHEMBL196666 | 71758 | 3 | None | 79 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 537 | 5 | 1 | 7 | 5.4 | COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(C(=O)c1ccc(-c3ccc(-c4noc(C)n4)cc3C)cc1)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| 44402886 | 71840 | 0 | None | 125 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 497 | 5 | 1 | 5 | 5.3 | COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(C(=O)c1ccc(-c3ccc(C(C)=O)cc3C)cc1)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| CHEMBL196951 | 71840 | 0 | None | 125 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 497 | 5 | 1 | 5 | 5.3 | COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(C(=O)c1ccc(-c3ccc(C(C)=O)cc3C)cc1)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| 11307899 | 78868 | 0 | None | -50 | 7 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 597 | 6 | 4 | 6 | 2.5 | CC(C)C[C@H]1C(=O)N[C@@H](Cc2ccccc2)[C@]2(O)O[C@@](C)(NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)C(=O)N12 | 10.1021/jm0341204 | |||
| CHEMBL2112882 | 78868 | 0 | None | -50 | 7 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 597 | 6 | 4 | 6 | 2.5 | CC(C)C[C@H]1C(=O)N[C@@H](Cc2ccccc2)[C@]2(O)O[C@@](C)(NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)C(=O)N12 | 10.1021/jm0341204 | |||
| 10370874 | 82595 | 0 | None | 1 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 484 | 9 | 1 | 6 | 5.8 | COc1ccc(NC(=O)c2ccc(-c3ccc(-c4noc(C)n4)cc3C)cc2)cc1CCCN(C)C | 10.1021/jm970457s | |||
| CHEMBL21790 | 82595 | 0 | None | 1 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 484 | 9 | 1 | 6 | 5.8 | COc1ccc(NC(=O)c2ccc(-c3ccc(-c4noc(C)n4)cc3C)cc2)cc1CCCN(C)C | 10.1021/jm970457s | |||
| 49850671 | 56391 | 0 | None | -6 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 483 | 6 | 2 | 4 | 5.7 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5ccc(F)cc5)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| CHEMBL1631537 | 56391 | 0 | None | -6 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 483 | 6 | 2 | 4 | 5.7 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5ccc(F)cc5)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| 11292933 | 56394 | 45 | None | -15 | 9 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 415 | 5 | 1 | 4 | 3.4 | Cc1ccc2c(N3CCN(CCc4cccc(N5CCNC5=O)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| CHEMBL1631540 | 56394 | 45 | None | -15 | 9 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 415 | 5 | 1 | 4 | 3.4 | Cc1ccc2c(N3CCN(CCc4cccc(N5CCNC5=O)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| 11419978 | 56463 | 0 | None | -12 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 468 | 6 | 1 | 4 | 5.3 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccccc5F)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| CHEMBL1632211 | 56463 | 0 | None | -12 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 468 | 6 | 1 | 4 | 5.3 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccccc5F)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| 49850877 | 56464 | 0 | None | -10 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 468 | 6 | 1 | 4 | 5.3 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cccc(F)c5)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| CHEMBL1632212 | 56464 | 0 | None | -10 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 468 | 6 | 1 | 4 | 5.3 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cccc(F)c5)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| 49850568 | 56470 | 0 | None | -7 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 4.9 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5csc(C)n5)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| CHEMBL1632218 | 56470 | 0 | None | -7 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 4.9 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5csc(C)n5)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| 11397149 | 56475 | 0 | None | -10 | 7 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 465 | 6 | 2 | 4 | 5.6 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5ccccc5)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| CHEMBL1632223 | 56475 | 0 | None | -10 | 7 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 465 | 6 | 2 | 4 | 5.6 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5ccccc5)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| 107780 | 1844 | 54 | None | -4 | 17 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm00041a001 | |||
| 14 | 1844 | 54 | None | -4 | 17 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm00041a001 | |||
| CHEMBL15928 | 1844 | 54 | None | -4 | 17 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm00041a001 | |||
| 44342993 | 11010 | 0 | None | -4 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 480 | 4 | 2 | 2 | 6.7 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(/C(S)=N/c4cccc5ccccc45)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
| CHEMBL117397 | 11010 | 0 | None | -4 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 480 | 4 | 2 | 2 | 6.7 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(/C(S)=N/c4cccc5ccccc45)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
| 10970604 | 5063 | 0 | None | 1 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 367 | 3 | 3 | 3 | 4.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)Nc4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL105369 | 5063 | 0 | None | 1 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 367 | 3 | 3 | 3 | 4.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)Nc4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| 11655728 | 16644 | 8 | None | -46 | 6 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 468 | 5 | 1 | 7 | 3.1 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
| CHEMBL1241913 | 16644 | 8 | None | -46 | 6 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 468 | 5 | 1 | 7 | 3.1 | Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1 | 10.1021/jm100482n | |||
| 1884 | 2735 | 58 | None | -3 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 10.1021/jm9805945 | |||
| 4440 | 2735 | 58 | None | -3 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 10.1021/jm9805945 | |||
| 45 | 2735 | 58 | None | -3 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 10.1021/jm9805945 | |||
| CHEMBL1278 | 2735 | 58 | None | -3 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 10.1021/jm9805945 | |||
| DB00952 | 2735 | 58 | None | -3 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 10.1021/jm9805945 | |||
| 59636740 | 125693 | 0 | None | - | 1 | Chinese hamster | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 532 | 9 | 1 | 7 | 3.7 | CS(=O)(=O)Cc1ccc(CNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)cc1 | nan | |||
| CHEMBL3647275 | 125693 | 0 | None | - | 1 | Chinese hamster | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 532 | 9 | 1 | 7 | 3.7 | CS(=O)(=O)Cc1ccc(CNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)cc1 | nan | |||
| 5 | 139 | 72 | None | -13 | 54 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00402a026 | |||
| 5202 | 139 | 72 | None | -13 | 54 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00402a026 | |||
| CHEMBL39 | 139 | 72 | None | -13 | 54 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00402a026 | |||
| DB08839 | 139 | 72 | None | -13 | 54 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00402a026 | |||
| 107 | 141 | 121 | None | -16 | 30 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10.1021/jm950498t | |||
| 1833 | 141 | 121 | None | -16 | 30 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10.1021/jm950498t | |||
| CHEMBL8165 | 141 | 121 | None | -16 | 30 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10.1021/jm950498t | |||
| 23533322 | 85070 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 477 | 5 | 2 | 7 | 2.4 | COc1cc(N2CCN(C)CC2)c2[nH]c(C(=O)Nc3ccc(N4CCOCC4)cc3)cc(=O)c2c1 | 10.1016/j.bmc.2006.10.037 | |||
| CHEMBL224399 | 85070 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 477 | 5 | 2 | 7 | 2.4 | COc1cc(N2CCN(C)CC2)c2[nH]c(C(=O)Nc3ccc(N4CCOCC4)cc3)cc(=O)c2c1 | 10.1016/j.bmc.2006.10.037 | |||
| 59636761 | 126209 | 0 | None | - | 1 | Chinese hamster | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 456 | 7 | 2 | 6 | 3.8 | O=C(NCc1cccc(O)c1)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| CHEMBL3650030 | 126209 | 0 | None | - | 1 | Chinese hamster | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 456 | 7 | 2 | 6 | 3.8 | O=C(NCc1cccc(O)c1)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| 44342508 | 9823 | 0 | None | -8 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 464 | 4 | 2 | 2 | 6.3 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(C(=O)Nc4cccc5ccccc45)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
| CHEMBL113893 | 9823 | 0 | None | -8 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 464 | 4 | 2 | 2 | 6.3 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(C(=O)Nc4cccc5ccccc45)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
| 44342518 | 9974 | 0 | None | -10 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 448 | 4 | 2 | 2 | 5.8 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(C(=O)Nc4ccc(Cl)cc4)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
| CHEMBL114780 | 9974 | 0 | None | -10 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 448 | 4 | 2 | 2 | 5.8 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(C(=O)Nc4ccc(Cl)cc4)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
| 3608822 | 98510 | 21 | None | 3 | 3 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 204 | 2 | 1 | 2 | 2.2 | CC(C)c1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
| CHEMBL276156 | 98510 | 21 | None | 3 | 3 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 204 | 2 | 1 | 2 | 2.2 | CC(C)c1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
| 75 | 3514 | 7 | None | -3 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 497 | 3 | 1 | 4 | 5.9 | CN1CCN(CC1)c1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(c2c1cccc2)c1ccncc1 | 10.1016/j.bmcl.2005.07.085 | |||
| 9870500 | 3514 | 7 | None | -3 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 497 | 3 | 1 | 4 | 5.9 | CN1CCN(CC1)c1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(c2c1cccc2)c1ccncc1 | 10.1016/j.bmcl.2005.07.085 | |||
| CHEMBL191971 | 3514 | 7 | None | -3 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 497 | 3 | 1 | 4 | 5.9 | CN1CCN(CC1)c1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(c2c1cccc2)c1ccncc1 | 10.1016/j.bmcl.2005.07.085 | |||
| 44402870 | 71115 | 0 | None | 3 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 434 | 3 | 1 | 4 | 4.3 | COc1cc2c(cc1N1CCN(C)CC1)N(C(=O)Nc1cccc(Cl)c1Cl)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| CHEMBL195432 | 71115 | 0 | None | 3 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 434 | 3 | 1 | 4 | 4.3 | COc1cc2c(cc1N1CCN(C)CC1)N(C(=O)Nc1cccc(Cl)c1Cl)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| 44402881 | 165814 | 0 | None | 39 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 480 | 3 | 1 | 4 | 5.0 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Nc1cccc(C(F)(F)F)c1F)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| CHEMBL424837 | 165814 | 0 | None | 39 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 480 | 3 | 1 | 4 | 5.0 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Nc1cccc(C(F)(F)F)c1F)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| 44402868 | 168345 | 0 | None | 31 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 534 | 5 | 0 | 5 | 6.3 | CCN1[C@@H](C)CN(c2cc3c(cc2OC)CCN3C(=O)c2ccc(-c3cccc(C)n3)c3ccccc23)C[C@H]1C | 10.1016/j.bmcl.2005.07.085 | |||
| CHEMBL434355 | 168345 | 0 | None | 31 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 534 | 5 | 0 | 5 | 6.3 | CCN1[C@@H](C)CN(c2cc3c(cc2OC)CCN3C(=O)c2ccc(-c3cccc(C)n3)c3ccccc23)C[C@H]1C | 10.1016/j.bmcl.2005.07.085 | |||
| 49850670 | 56390 | 0 | None | -6 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 483 | 6 | 2 | 4 | 5.7 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5cccc(F)c5)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| CHEMBL1631536 | 56390 | 0 | None | -6 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 483 | 6 | 2 | 4 | 5.7 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5cccc(F)c5)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| 49850982 | 56466 | 0 | None | -6 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 480 | 7 | 1 | 5 | 5.2 | COc1ccccc1C(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
| CHEMBL1632214 | 56466 | 0 | None | -6 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 480 | 7 | 1 | 5 | 5.2 | COc1ccccc1C(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm100714c | |||
| 49850566 | 56468 | 0 | None | -7 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 480 | 7 | 1 | 5 | 5.2 | COc1ccc(C(=O)Nc2cccc(CCN3CCN(c4cccc5nc(C)ccc45)CC3)c2)cc1 | 10.1021/jm100714c | |||
| CHEMBL1632216 | 56468 | 0 | None | -7 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 480 | 7 | 1 | 5 | 5.2 | COc1ccc(C(=O)Nc2cccc(CCN3CCN(c4cccc5nc(C)ccc45)CC3)c2)cc1 | 10.1021/jm100714c | |||
| 49850668 | 56474 | 0 | None | -15 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 445 | 5 | 2 | 4 | 4.8 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)NC(C)(C)C)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| CHEMBL1632222 | 56474 | 0 | None | -15 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 445 | 5 | 2 | 4 | 4.8 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)NC(C)(C)C)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| 22326688 | 93597 | 0 | None | -4 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 459 | 7 | 0 | 5 | 4.6 | CCN1C(=O)COc2ccc(CC3CCN(CCOc4cccc5nc(C)ccc45)CC3)cc21 | 10.1016/j.bmcl.2007.06.078 | |||
| CHEMBL246598 | 93597 | 0 | None | -4 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 459 | 7 | 0 | 5 | 4.6 | CCN1C(=O)COc2ccc(CC3CCN(CCOc4cccc5nc(C)ccc45)CC3)cc21 | 10.1016/j.bmcl.2007.06.078 | |||
| 10174078 | 176894 | 0 | None | -5 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 472 | 7 | 1 | 5 | 5.1 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5C[C@H](C)N[C@H](C)C5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| CHEMBL461670 | 176894 | 0 | None | -5 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 472 | 7 | 1 | 5 | 5.1 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5C[C@H](C)N[C@H](C)C5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| 44404260 | 72352 | 0 | None | 1 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 519 | 5 | 0 | 7 | 4.6 | CCc1c(C(=O)N2CCc3cc4ccnc(N5CCN(C(C)C)CC5)c4cc32)cnn1-c1ccc(C#N)cc1 | 10.1016/j.bmcl.2005.06.042 | |||
| CHEMBL198488 | 72352 | 0 | None | 1 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 519 | 5 | 0 | 7 | 4.6 | CCc1c(C(=O)N2CCc3cc4ccnc(N5CCN(C(C)C)CC5)c4cc32)cnn1-c1ccc(C#N)cc1 | 10.1016/j.bmcl.2005.06.042 | |||
| 115 | 3791 | 80 | None | 1 | 27 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 10.1021/jm00384a001 | |||
| 4296 | 3791 | 80 | None | 1 | 27 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 10.1021/jm00384a001 | |||
| CHEMBL274866 | 3791 | 80 | None | 1 | 27 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 10.1021/jm00384a001 | |||
| 10299410 | 85057 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 479 | 5 | 1 | 7 | 3.2 | COc1cc(C(=O)Nc2ccc(N3CCOCC3)cc2)nc2c(N3CCN(C)CC3)cc(F)cc12 | 10.1016/j.bmc.2006.10.037 | |||
| CHEMBL224267 | 85057 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 479 | 5 | 1 | 7 | 3.2 | COc1cc(C(=O)Nc2ccc(N3CCOCC3)cc2)nc2c(N3CCN(C)CC3)cc(F)cc12 | 10.1016/j.bmc.2006.10.037 | |||
| 77418 | 97397 | 64 | None | 3 | 2 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 180 | 1 | 1 | 2 | 1.2 | Fc1cccc(N2CCNCC2)c1 | 10.1021/jm00125a020 | |||
| CHEMBL269784 | 97397 | 64 | None | 3 | 2 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 180 | 1 | 1 | 2 | 1.2 | Fc1cccc(N2CCNCC2)c1 | 10.1021/jm00125a020 | |||
| 10620719 | 204350 | 0 | None | -794 | 5 | Western lowland gorilla | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 395 | 6 | 1 | 5 | 2.6 | COc1ccc(N2CCN(CC[C@@H]3OCCc4cc(C(N)=O)ccc43)CC2)cc1 | 10.1021/jm980137o | |||
| CHEMBL71635 | 204350 | 0 | None | -794 | 5 | Western lowland gorilla | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 395 | 6 | 1 | 5 | 2.6 | COc1ccc(N2CCN(CC[C@@H]3OCCc4cc(C(N)=O)ccc43)CC2)cc1 | 10.1021/jm980137o | |||
| 9995233 | 165111 | 0 | None | -39 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 304 | 4 | 1 | 2 | 4.7 | CN(C)CCc1c[nH]c2ccc(-c3ccc(Cl)s3)cc12 | 10.1016/s0960-894x(00)00133-5 | |||
| CHEMBL422737 | 165111 | 0 | None | -39 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 304 | 4 | 1 | 2 | 4.7 | CN(C)CCc1c[nH]c2ccc(-c3ccc(Cl)s3)cc12 | 10.1016/s0960-894x(00)00133-5 | |||
| 10379784 | 204382 | 1 | None | -251 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 295 | 5 | 1 | 2 | 4.0 | CCCN(CCC)[C@H]1CCc2ccc3[nH]cc(C#N)c3c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL71804 | 204382 | 1 | None | -251 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 295 | 5 | 1 | 2 | 4.0 | CCCN(CCC)[C@H]1CCc2ccc3[nH]cc(C#N)c3c2C1 | 10.1021/jm00012a021 | |||
| 11123573 | 208024 | 0 | None | 1 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 473 | 6 | 2 | 5 | 3.8 | O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4c[nH]nn4)cc23)CC1 | 10.1021/jm020938y | |||
| CHEMBL97422 | 208024 | 0 | None | 1 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 473 | 6 | 2 | 5 | 3.8 | O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4c[nH]nn4)cc23)CC1 | 10.1021/jm020938y | |||
| 44438461 | 90973 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 452 | 6 | 0 | 6 | 5.0 | CC(C)N1CCN(C2CCc3ccc(OCc4noc(-c5ccc(Cl)cc5)n4)cc32)CC1 | 10.1016/j.bmcl.2006.12.109 | |||
| CHEMBL239596 | 90973 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 452 | 6 | 0 | 6 | 5.0 | CC(C)N1CCN(C2CCc3ccc(OCc4noc(-c5ccc(Cl)cc5)n4)cc32)CC1 | 10.1016/j.bmcl.2006.12.109 | |||
| 59636742 | 125701 | 0 | None | - | 1 | Chinese hamster | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 455 | 7 | 0 | 6 | 3.9 | CN(Cc1ccccn1)C(=O)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| CHEMBL3647283 | 125701 | 0 | None | - | 1 | Chinese hamster | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 455 | 7 | 0 | 6 | 3.9 | CN(Cc1ccccn1)C(=O)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| 44402869 | 134143 | 0 | None | 2 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 548 | 6 | 0 | 5 | 6.7 | CCCN1[C@@H](C)CN(c2cc3c(cc2OC)CCN3C(=O)c2ccc(-c3cccc(C)n3)c3ccccc23)C[C@H]1C | 10.1016/j.bmcl.2005.07.085 | |||
| CHEMBL371655 | 134143 | 0 | None | 2 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 548 | 6 | 0 | 5 | 6.7 | CCCN1[C@@H](C)CN(c2cc3c(cc2OC)CCN3C(=O)c2ccc(-c3cccc(C)n3)c3ccccc23)C[C@H]1C | 10.1016/j.bmcl.2005.07.085 | |||
| 10838923 | 52635 | 0 | None | 31 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 494 | 4 | 1 | 6 | 5.6 | Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc5c(c4)C4(CCN(C)CC4)CO5)cc3)c(C)c2)no1 | 10.1021/jm970457s | |||
| CHEMBL15933 | 52635 | 0 | None | 31 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 494 | 4 | 1 | 6 | 5.6 | Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc5c(c4)C4(CCN(C)CC4)CO5)cc3)c(C)c2)no1 | 10.1021/jm970457s | |||
| 22326704 | 144937 | 0 | None | -12 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 449 | 6 | 1 | 5 | 4.3 | Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)c(F)ccc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
| CHEMBL391033 | 144937 | 0 | None | -12 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 449 | 6 | 1 | 5 | 4.3 | Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)c(F)ccc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
| 49850770 | 56397 | 0 | None | -125 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 430 | 5 | 0 | 5 | 4.3 | Cc1ccc2c(N3CCN(CCc4cccc(N5CCCOC5=O)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| CHEMBL1631543 | 56397 | 0 | None | -125 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 430 | 5 | 0 | 5 | 4.3 | Cc1ccc2c(N3CCN(CCc4cccc(N5CCCOC5=O)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| 44443095 | 93598 | 0 | None | -15 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 474 | 8 | 0 | 6 | 3.9 | CCCN1C(=O)COc2ccc(CN3CCN(CCOc4cccc5nc(C)ccc45)CC3)cc21 | 10.1016/j.bmcl.2007.06.078 | |||
| CHEMBL246599 | 93598 | 0 | None | -15 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 474 | 8 | 0 | 6 | 3.9 | CCCN1C(=O)COc2ccc(CN3CCN(CCOc4cccc5nc(C)ccc45)CC3)cc21 | 10.1016/j.bmcl.2007.06.078 | |||
| 44443096 | 93927 | 0 | None | -25 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 488 | 9 | 0 | 6 | 4.3 | CCCCN1C(=O)COc2ccc(CN3CCN(CCOc4cccc5nc(C)ccc45)CC3)cc21 | 10.1016/j.bmcl.2007.06.078 | |||
| CHEMBL248229 | 93927 | 0 | None | -25 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 488 | 9 | 0 | 6 | 4.3 | CCCCN1C(=O)COc2ccc(CN3CCN(CCOc4cccc5nc(C)ccc45)CC3)cc21 | 10.1016/j.bmcl.2007.06.078 | |||
| 44443097 | 93928 | 0 | None | -15 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 488 | 8 | 0 | 6 | 4.1 | Cc1ccc2c(OCCN3CCN(Cc4ccc5c(c4)N(CC(C)C)C(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2007.06.078 | |||
| CHEMBL248230 | 93928 | 0 | None | -15 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 488 | 8 | 0 | 6 | 4.1 | Cc1ccc2c(OCCN3CCN(Cc4ccc5c(c4)N(CC(C)C)C(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2007.06.078 | |||
| 44581260 | 175592 | 0 | None | -31 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 472 | 7 | 1 | 5 | 5.1 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5C[C@@H](C)NC[C@@H]5C)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| CHEMBL457982 | 175592 | 0 | None | -31 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 472 | 7 | 1 | 5 | 5.1 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5C[C@@H](C)NC[C@@H]5C)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| 10452875 | 193165 | 0 | None | -125 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 388 | 4 | 1 | 5 | 2.9 | O=C1COc2ccc(CCN3CCN(c4cccc5cccnc45)CC3)cc2N1 | 10.1016/j.bmcl.2008.08.084 | |||
| CHEMBL523095 | 193165 | 0 | None | -125 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 388 | 4 | 1 | 5 | 2.9 | O=C1COc2ccc(CCN3CCN(c4cccc5cccnc45)CC3)cc2N1 | 10.1016/j.bmcl.2008.08.084 | |||
| 173 | 3262 | 95 | None | -2 | 23 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm970645i | |||
| 5011 | 3262 | 95 | None | -2 | 23 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm970645i | |||
| CHEMBL18772 | 3262 | 95 | None | -2 | 23 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm970645i | |||
| 173 | 3262 | 95 | None | -2 | 23 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm981112s | |||
| 5011 | 3262 | 95 | None | -2 | 23 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm981112s | |||
| CHEMBL18772 | 3262 | 95 | None | -2 | 23 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm981112s | |||
| 44461247 | 104756 | 0 | None | -43 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 422 | 5 | 2 | 4 | 3.2 | NC(=O)c1ccc2c(c1)CCOC2CCN1CCN(c2c[nH]c3cc(F)ccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
| CHEMBL310744 | 104756 | 0 | None | -43 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 422 | 5 | 2 | 4 | 3.2 | NC(=O)c1ccc2c(c1)CCOC2CCN1CCN(c2c[nH]c3cc(F)ccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
| 11824522 | 4890 | 0 | None | -42 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 359 | 3 | 2 | 4 | 3.5 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(C#N)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL104484 | 4890 | 0 | None | -42 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 359 | 3 | 2 | 4 | 3.5 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(C#N)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| 6918601 | 18523 | 0 | None | -407 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 370 | 3 | 1 | 5 | 2.7 | Cc1ccc(S(=O)(=O)n2cc3c4c(cccc42)[C@H](O)[C@@H](N(C)C)C3)cc1 | 10.1021/jm010943m | |||
| CHEMBL127411 | 18523 | 0 | None | -407 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 370 | 3 | 1 | 5 | 2.7 | Cc1ccc(S(=O)(=O)n2cc3c4c(cccc42)[C@H](O)[C@@H](N(C)C)C3)cc1 | 10.1021/jm010943m | |||
| 22067856 | 29540 | 52 | None | 1 | 3 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 165 | 5 | 1 | 2 | 1.7 | CNCCCOc1ccccc1 | 10.1021/jm00124a021 | |||
| CHEMBL138509 | 29540 | 52 | None | 1 | 3 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 165 | 5 | 1 | 2 | 1.7 | CNCCCOc1ccccc1 | 10.1021/jm00124a021 | |||
| 11777940 | 101431 | 0 | None | -123 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 270 | 3 | 1 | 1 | 4.1 | CC(C)(C)c1ccc2[nH]cc(CCN3CCCC3)c2c1 | 10.1016/s0960-894x(00)00322-x | |||
| CHEMBL297471 | 101431 | 0 | None | -123 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 270 | 3 | 1 | 1 | 4.1 | CC(C)(C)c1ccc2[nH]cc(CCN3CCCC3)c2c1 | 10.1016/s0960-894x(00)00322-x | |||
| 44461306 | 205931 | 0 | None | -12 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 431 | 6 | 2 | 4 | 4.1 | COc1ccc2[nH]cc(C3=CCN(CCC4OCCc5cc(C(N)=O)ccc54)CC3)c2c1 | 10.1016/j.bmcl.2004.03.003 | |||
| CHEMBL84171 | 205931 | 0 | None | -12 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 431 | 6 | 2 | 4 | 4.1 | COc1ccc2[nH]cc(C3=CCN(CCC4OCCc5cc(C(N)=O)ccc54)CC3)c2c1 | 10.1016/j.bmcl.2004.03.003 | |||
| 44364048 | 39139 | 0 | None | -158 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 262 | 6 | 3 | 3 | 2.3 | NCCCC1(CCCN)CCc2cccc(O)c2C1 | 10.1021/jm0341204 | |||
| CHEMBL146942 | 39139 | 0 | None | -158 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 262 | 6 | 3 | 3 | 2.3 | NCCCC1(CCCN)CCc2cccc(O)c2C1 | 10.1021/jm0341204 | |||
| 10022680 | 19522 | 0 | None | -251 | 2 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 380 | 5 | 0 | 5 | 3.3 | COc1ccc2c(c1)C(CCN1CCN(c3cccc4c3OCCO4)CC1)C2 | 10.1021/jm00020a020 | |||
| CHEMBL129947 | 19522 | 0 | None | -251 | 2 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 380 | 5 | 0 | 5 | 3.3 | COc1ccc2c(c1)C(CCN1CCN(c3cccc4c3OCCO4)CC1)C2 | 10.1021/jm00020a020 | |||
| 10066717 | 20833 | 0 | None | -177 | 2 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 354 | 3 | 0 | 4 | 3.1 | Fc1cccc2c1CC2CN1CCN(c2cccc3c2OCCO3)CC1 | 10.1021/jm00020a020 | |||
| CHEMBL131018 | 20833 | 0 | None | -177 | 2 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 354 | 3 | 0 | 4 | 3.1 | Fc1cccc2c1CC2CN1CCN(c2cccc3c2OCCO3)CC1 | 10.1021/jm00020a020 | |||
| 9889681 | 208063 | 0 | None | -630 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 444 | 5 | 2 | 5 | 4.1 | O=S(=O)(Nc1ccc2nccc(N3CCNCC3)c2c1)c1ccc(-c2ccccc2)cc1 | 10.1016/s0960-894x(01)00558-3 | |||
| CHEMBL97637 | 208063 | 0 | None | -630 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 444 | 5 | 2 | 5 | 4.1 | O=S(=O)(Nc1ccc2nccc(N3CCNCC3)c2c1)c1ccc(-c2ccccc2)cc1 | 10.1016/s0960-894x(01)00558-3 | |||
| 75306277 | 109254 | 0 | None | -158 | 23 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 308 | 0 | 0 | 3 | 4.2 | CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3 | 10.1039/C2MD00311B | |||
| CHEMBL3217984 | 109254 | 0 | None | -158 | 23 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 308 | 0 | 0 | 3 | 4.2 | CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3 | 10.1039/C2MD00311B | |||
| 11168182 | 3534 | 25 | None | -50 | 13 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 511 | 14 | 1 | 3 | 6.5 | CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C | 10.1016/j.bmcl.2005.06.024 | |||
| 264 | 3534 | 25 | None | -50 | 13 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 511 | 14 | 1 | 3 | 6.5 | CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C | 10.1016/j.bmcl.2005.06.024 | |||
| CHEMBL1181770 | 3534 | 25 | None | -50 | 13 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 511 | 14 | 1 | 3 | 6.5 | CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C | 10.1016/j.bmcl.2005.06.024 | |||
| 11476072 | 69401 | 0 | None | -15 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 436 | 8 | 0 | 7 | 3.7 | COc1ccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)cc1[N+](=O)[O-] | 10.1021/jm049039v | |||
| CHEMBL193268 | 69401 | 0 | None | -15 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 436 | 8 | 0 | 7 | 3.7 | COc1ccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)cc1[N+](=O)[O-] | 10.1021/jm049039v | |||
| 11235335 | 124025 | 0 | None | -125 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 413 | 6 | 0 | 6 | 3.7 | Cc1ccc2c(OCCN3CCN(Cc4cccc5ncncc45)CC3)cccc2n1 | 10.1021/jm049039v | |||
| CHEMBL362992 | 124025 | 0 | None | -125 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 413 | 6 | 0 | 6 | 3.7 | Cc1ccc2c(OCCN3CCN(Cc4cccc5ncncc45)CC3)cccc2n1 | 10.1021/jm049039v | |||
| 9804612 | 90535 | 0 | None | -79 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 467 | 6 | 1 | 5 | 4.5 | Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(F)cc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
| CHEMBL238730 | 90535 | 0 | None | -79 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 467 | 6 | 1 | 5 | 4.5 | Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(F)cc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
| 44588722 | 191241 | 0 | None | -3 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 433 | 8 | 1 | 6 | 3.7 | Cc1ccc2c(OCCCN3CC(COc4ccc5c(c4)NC(=O)CO5)C3)cccc2n1 | 10.1016/j.bmcl.2008.08.110 | |||
| CHEMBL519010 | 191241 | 0 | None | -3 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 433 | 8 | 1 | 6 | 3.7 | Cc1ccc2c(OCCCN3CC(COc4ccc5c(c4)NC(=O)CO5)C3)cccc2n1 | 10.1016/j.bmcl.2008.08.110 | |||
| 9870053 | 208284 | 0 | None | -2511 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 486 | 5 | 2 | 6 | 4.9 | CCc1c(S(=O)(=O)Nc2ccc3nccc(N4CCNCC4)c3c2)sc2ccc(Cl)cc12 | 10.1016/s0960-894x(01)00558-3 | |||
| CHEMBL98965 | 208284 | 0 | None | -2511 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 486 | 5 | 2 | 6 | 4.9 | CCc1c(S(=O)(=O)Nc2ccc3nccc(N4CCNCC4)c3c2)sc2ccc(Cl)cc12 | 10.1016/s0960-894x(01)00558-3 | |||
| 10198700 | 120796 | 3 | None | -18 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 242 | 3 | 2 | 2 | 3.4 | NCCc1c[nH]c2ccc(-c3cccs3)cc12 | 10.1016/s0960-894x(00)00133-5 | |||
| CHEMBL355517 | 120796 | 3 | None | -18 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 242 | 3 | 2 | 2 | 3.4 | NCCc1c[nH]c2ccc(-c3cccs3)cc12 | 10.1016/s0960-894x(00)00133-5 | |||
| 44376383 | 55539 | 0 | None | -4 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 444 | 6 | 2 | 3 | 5.1 | Cc1ccc(C(=S)NN2CC=C(c3ccc4[nH]cc(CCN5CCCC5)c4c3)CC2)cc1 | 10.1016/j.bmcl.2003.11.023 | |||
| CHEMBL162049 | 55539 | 0 | None | -4 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 444 | 6 | 2 | 3 | 5.1 | Cc1ccc(C(=S)NN2CC=C(c3ccc4[nH]cc(CCN5CCCC5)c4c3)CC2)cc1 | 10.1016/j.bmcl.2003.11.023 | |||
| 9802530 | 35386 | 1 | None | -2 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 336 | 5 | 1 | 4 | 2.5 | CN(C)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
| CHEMBL143767 | 35386 | 1 | None | -2 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 336 | 5 | 1 | 4 | 2.5 | CN(C)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12 | 10.1021/jm9604890 | |||
| 24881686 | 188389 | 0 | None | -8 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 832 | 18 | 4 | 7 | 8.5 | O=C(Nc1ccc2[nH]cc(C3CCN(CCOCCOCCOCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | 10.1021/jm7011722 | |||
| CHEMBL501645 | 188389 | 0 | None | -8 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 832 | 18 | 4 | 7 | 8.5 | O=C(Nc1ccc2[nH]cc(C3CCN(CCOCCOCCOCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | 10.1021/jm7011722 | |||
| 11728004 | 4453 | 0 | None | -1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 356 | 8 | 2 | 3 | 4.7 | CCCCCCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| CHEMBL101686 | 4453 | 0 | None | -1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 356 | 8 | 2 | 3 | 4.7 | CCCCCCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| 173 | 3262 | 95 | None | -2 | 23 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm00384a001 | |||
| 5011 | 3262 | 95 | None | -2 | 23 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm00384a001 | |||
| CHEMBL18772 | 3262 | 95 | None | -2 | 23 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | 10.1021/jm00384a001 | |||
| 44269070 | 31222 | 0 | None | -162 | 2 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 440 | 6 | 0 | 5 | 3.3 | COc1cccc2c1C1CCN(CCCCN3C(=O)c4ccccc4S3(=O)=O)CC1C2 | 10.1021/jm00027a013 | |||
| CHEMBL14010 | 31222 | 0 | None | -162 | 2 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 440 | 6 | 0 | 5 | 3.3 | COc1cccc2c1C1CCN(CCCCN3C(=O)c4ccccc4S3(=O)=O)CC1C2 | 10.1021/jm00027a013 | |||
| 4806 | 4008 | 88 | None | -2 | 13 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | |||
| 7351 | 4008 | 88 | None | -2 | 13 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | |||
| 9966051 | 4008 | 88 | None | -2 | 13 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | |||
| CHEMBL2104993 | 4008 | 88 | None | -2 | 13 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | |||
| DB09068 | 4008 | 88 | None | -2 | 13 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | |||
| 11568826 | 132798 | 0 | None | -28 | 8 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5cncc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
| CHEMBL370110 | 132798 | 0 | None | -28 | 8 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 460 | 4 | 0 | 8 | 2.8 | CN1CCc2c(sc3ncn(CCN4CCN(c5cncc6ccccc56)CC4)c(=O)c23)C1 | 10.1016/j.bmcl.2005.04.077 | |||
| 2760216 | 97061 | 81 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 207 | 2 | 1 | 4 | 1.0 | O=[N+]([O-])c1cccc(N2CCNCC2)c1 | 10.1021/jm00125a020 | |||
| CHEMBL267153 | 97061 | 81 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 207 | 2 | 1 | 4 | 1.0 | O=[N+]([O-])c1cccc(N2CCNCC2)c1 | 10.1021/jm00125a020 | |||
| 11759467 | 5169 | 0 | None | -39 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 335 | 3 | 2 | 4 | 3.0 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccncc4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL105958 | 5169 | 0 | None | -39 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 335 | 3 | 2 | 4 | 3.0 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccncc4)nc23)CC1 | 10.1021/jm030020m | |||
| 10331436 | 324 | 10 | None | -1659 | 6 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 230 | 2 | 2 | 2 | 2.4 | C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N | 10.1021/jm030205t | |||
| 160 | 324 | 10 | None | -1659 | 6 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 230 | 2 | 2 | 2 | 2.4 | C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N | 10.1021/jm030205t | |||
| CHEMBL133455 | 324 | 10 | None | -1659 | 6 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 230 | 2 | 2 | 2 | 2.4 | C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N | 10.1021/jm030205t | |||
| 44582705 | 186996 | 0 | None | -21 | 13 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 399 | 9 | 0 | 4 | 4.5 | COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | |||
| CHEMBL490632 | 186996 | 0 | None | -21 | 13 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 399 | 9 | 0 | 4 | 4.5 | COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | |||
| 59636771 | 126207 | 0 | None | - | 1 | Chinese hamster | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 441 | 7 | 1 | 6 | 3.5 | O=C(NCc1cccnc1)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| CHEMBL3650028 | 126207 | 0 | None | - | 1 | Chinese hamster | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 441 | 7 | 1 | 6 | 3.5 | O=C(NCc1cccnc1)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| 9910451 | 164130 | 0 | None | -338 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 428 | 5 | 0 | 6 | 4.7 | Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCC#N)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | |||
| CHEMBL420997 | 164130 | 0 | None | -338 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 428 | 5 | 0 | 6 | 4.7 | Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCC#N)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | |||
| 145988313 | 167235 | 0 | None | -758 | 5 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 451 | 6 | 2 | 2 | 5.0 | O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1 | 10.1039/C8MD00204E | |||
| CHEMBL4292326 | 167235 | 0 | None | -758 | 5 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 451 | 6 | 2 | 2 | 5.0 | O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1 | 10.1039/C8MD00204E | |||
| 9881478 | 6651 | 27 | None | 3 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 216 | 1 | 2 | 2 | 2.0 | COc1ccc2[nH]c3c(c2c1)CC(N)CC3 | 10.1021/jm950498t | |||
| CHEMBL108337 | 6651 | 27 | None | 3 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 216 | 1 | 2 | 2 | 2.0 | COc1ccc2[nH]c3c(c2c1)CC(N)CC3 | 10.1021/jm950498t | |||
| 3016908 | 204444 | 24 | None | -47 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 202 | 2 | 1 | 2 | 2.2 | Cc1cc(C)c(CC2=NCCN2)c(C)c1 | 10.1021/jm970513p | |||
| CHEMBL72178 | 204444 | 24 | None | -47 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 202 | 2 | 1 | 2 | 2.2 | Cc1cc(C)c(CC2=NCCN2)c(C)c1 | 10.1021/jm970513p | |||
| 13096730 | 203366 | 5 | None | -54 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 270 | 5 | 1 | 1 | 4.1 | CCCN(CCC)C1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL65196 | 203366 | 5 | None | -54 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 270 | 5 | 1 | 1 | 4.1 | CCCN(CCC)C1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a021 | |||
| 13096730 | 203366 | 5 | None | -54 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 270 | 5 | 1 | 1 | 4.1 | CCCN(CCC)C1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL65196 | 203366 | 5 | None | -54 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 270 | 5 | 1 | 1 | 4.1 | CCCN(CCC)C1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
| 10567450 | 9355 | 1 | None | 1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 316 | 12 | 2 | 2 | 5.2 | CCCCCCCCCCOc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
| CHEMBL111284 | 9355 | 1 | None | 1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 316 | 12 | 2 | 2 | 5.2 | CCCCCCCCCCOc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
| 44422352 | 138149 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 491 | 6 | 2 | 7 | 2.8 | COc1cc(N2CC[C@@H](N(C)C)C2)c2[nH]c(C(=O)Nc3ccc(N4CCOCC4)cc3)cc(=O)c2c1 | 10.1016/j.bmc.2006.10.037 | |||
| CHEMBL376813 | 138149 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 491 | 6 | 2 | 7 | 2.8 | COc1cc(N2CC[C@@H](N(C)C)C2)c2[nH]c(C(=O)Nc3ccc(N4CCOCC4)cc3)cc(=O)c2c1 | 10.1016/j.bmc.2006.10.037 | |||
| 59636769 | 125703 | 0 | None | - | 1 | Chinese hamster | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 467 | 7 | 1 | 6 | 4.0 | O=C(NC1(c2ccccn2)CC1)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| CHEMBL3647285 | 125703 | 0 | None | - | 1 | Chinese hamster | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 467 | 7 | 1 | 6 | 4.0 | O=C(NC1(c2ccccn2)CC1)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| 145 | 140 | 49 | None | -47 | 30 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00399a031 | |||
| 1832 | 140 | 49 | None | -47 | 30 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00399a031 | |||
| CHEMBL7257 | 140 | 49 | None | -47 | 30 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00399a031 | |||
| DB14010 | 140 | 49 | None | -47 | 30 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00399a031 | |||
| 11831220 | 192558 | 8 | None | -8 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 229 | 1 | 2 | 2 | 2.6 | CN1CCC(c2c[nH]c3ccc(N)cc23)CC1 | 10.1021/jm7011722 | |||
| CHEMBL521235 | 192558 | 8 | None | -8 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 229 | 1 | 2 | 2 | 2.6 | CN1CCC(c2c[nH]c3ccc(N)cc23)CC1 | 10.1021/jm7011722 | |||
| 142601343 | 185603 | 0 | None | -123 | 7 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 256 | 2 | 2 | 3 | 2.2 | Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
| CHEMBL4863868 | 185603 | 0 | None | -123 | 7 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 256 | 2 | 2 | 3 | 2.2 | Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
| 9848303 | 111580 | 0 | None | -12 | 9 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 487 | 6 | 1 | 6 | 3.8 | Cn1cc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)nn1 | 10.1021/jm020938y | |||
| CHEMBL328187 | 111580 | 0 | None | -12 | 9 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 487 | 6 | 1 | 6 | 3.8 | Cn1cc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)nn1 | 10.1021/jm020938y | |||
| 2543 | 3707 | 68 | None | -3 | 32 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(00)00133-5 | |||
| 5358 | 3707 | 68 | None | -3 | 32 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(00)00133-5 | |||
| 54 | 3707 | 68 | None | -3 | 32 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(00)00133-5 | |||
| CHEMBL128 | 3707 | 68 | None | -3 | 32 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(00)00133-5 | |||
| DB00669 | 3707 | 68 | None | -3 | 32 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(00)00133-5 | |||
| 44376282 | 120108 | 0 | None | -3 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 464 | 6 | 2 | 3 | 5.4 | S=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2003.11.023 | |||
| CHEMBL351036 | 120108 | 0 | None | -3 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 464 | 6 | 2 | 3 | 5.4 | S=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2003.11.023 | |||
| 1150 | 3878 | 121 | None | -7 | 25 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 10.1021/jm950498t | |||
| 125 | 3878 | 121 | None | -7 | 25 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 10.1021/jm950498t | |||
| CHEMBL6640 | 3878 | 121 | None | -7 | 25 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 10.1021/jm950498t | |||
| DB08653 | 3878 | 121 | None | -7 | 25 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 10.1021/jm950498t | |||
| 9859280 | 106334 | 1 | None | 56 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 219 | 4 | 1 | 2 | 2.6 | CNCCOc1cccc(Cl)c1Cl | 10.1007/s00044-009-9164-1 | |||
| CHEMBL2260920 | 106334 | 1 | None | 56 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 219 | 4 | 1 | 2 | 2.6 | CNCCOc1cccc(Cl)c1Cl | 10.1007/s00044-009-9164-1 | |||
| CHEMBL3139165 | 106334 | 1 | None | 56 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 219 | 4 | 1 | 2 | 2.6 | CNCCOc1cccc(Cl)c1Cl | 10.1007/s00044-009-9164-1 | |||
| 11092112 | 207628 | 0 | None | -645 | 8 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 485 | 6 | 0 | 6 | 4.9 | O=C1OCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4ncccn4)cc23)CC1 | 10.1021/jm020938y | |||
| CHEMBL95175 | 207628 | 0 | None | -645 | 8 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 485 | 6 | 0 | 6 | 4.9 | O=C1OCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4ncccn4)cc23)CC1 | 10.1021/jm020938y | |||
| 10850769 | 201832 | 0 | None | - | 1 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 286 | 3 | 0 | 5 | 1.7 | CN1CCOC(COc2cccc3c2OCC(C#N)=C3)C1 | 10.1021/jm970806i | |||
| CHEMBL60705 | 201832 | 0 | None | - | 1 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 286 | 3 | 0 | 5 | 1.7 | CN1CCOC(COc2cccc3c2OCC(C#N)=C3)C1 | 10.1021/jm970806i | |||
| 44554395 | 18723 | 0 | None | -2290 | 7 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 406 | 3 | 1 | 6 | 3.0 | Cn1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CCNCC3)ccc21 | 10.1021/jm1007825 | |||
| CHEMBL1277565 | 18723 | 0 | None | -2290 | 7 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 406 | 3 | 1 | 6 | 3.0 | Cn1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CCNCC3)ccc21 | 10.1021/jm1007825 | |||
| 107992 | 2553 | 49 | None | -12 | 10 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 198 | 1 | 1 | 4 | 0.5 | Clc1cncc(n1)N1CCNCC1 | 10.1021/jm00145a017 | |||
| 165 | 2553 | 49 | None | -12 | 10 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 198 | 1 | 1 | 4 | 0.5 | Clc1cncc(n1)N1CCNCC1 | 10.1021/jm00145a017 | |||
| CHEMBL269521 | 2553 | 49 | None | -12 | 10 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 198 | 1 | 1 | 4 | 0.5 | Clc1cncc(n1)N1CCNCC1 | 10.1021/jm00145a017 | |||
| DB12111 | 2553 | 49 | None | -12 | 10 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 198 | 1 | 1 | 4 | 0.5 | Clc1cncc(n1)N1CCNCC1 | 10.1021/jm00145a017 | |||
| 178081 | 102649 | 8 | None | -707 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 298 | 6 | 1 | 2 | 4.0 | CCCN(CCC)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL304426 | 102649 | 8 | None | -707 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 298 | 6 | 1 | 2 | 4.0 | CCCN(CCC)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a021 | |||
| 16614092 | 106241 | 5 | None | 1 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 219 | 4 | 1 | 2 | 2.6 | CNCCOc1cc(Cl)ccc1Cl | 10.1007/s00044-009-9164-1 | |||
| CHEMBL2260922 | 106241 | 5 | None | 1 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 219 | 4 | 1 | 2 | 2.6 | CNCCOc1cc(Cl)ccc1Cl | 10.1007/s00044-009-9164-1 | |||
| CHEMBL3138881 | 106241 | 5 | None | 1 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 219 | 4 | 1 | 2 | 2.6 | CNCCOc1cc(Cl)ccc1Cl | 10.1007/s00044-009-9164-1 | |||
| 9837525 | 103155 | 1 | None | -33 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 230 | 3 | 1 | 2 | 3.0 | Cc1cc(C(C)C)cc(C)c1CC1=NCCN1 | 10.1021/jm970513p | |||
| CHEMBL308042 | 103155 | 1 | None | -33 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 230 | 3 | 1 | 2 | 3.0 | Cc1cc(C(C)C)cc(C)c1CC1=NCCN1 | 10.1021/jm970513p | |||
| 59636775 | 125681 | 0 | None | - | 1 | Chinese hamster | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 444 | 7 | 1 | 7 | 2.9 | Cn1cnc(CNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)c1 | nan | |||
| CHEMBL3647263 | 125681 | 0 | None | - | 1 | Chinese hamster | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 444 | 7 | 1 | 7 | 2.9 | Cn1cnc(CNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)c1 | nan | |||
| 4595 | 176715 | 106 | None | -7 | 15 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 293 | 2 | 0 | 4 | 3.1 | Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O | 10.1021/jm00075a026 | |||
| CHEMBL46 | 176715 | 106 | None | -7 | 15 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 293 | 2 | 0 | 4 | 3.1 | Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O | 10.1021/jm00075a026 | |||
| 11725335 | 102270 | 0 | None | -33 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 348 | 6 | 1 | 3 | 3.6 | CCCN(CCC)C1CCc2ccc3[nH]cc(S(C)(=O)=O)c3c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL303269 | 102270 | 0 | None | -33 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 348 | 6 | 1 | 3 | 3.6 | CCCN(CCC)C1CCc2ccc3[nH]cc(S(C)(=O)=O)c3c2C1 | 10.1021/jm00012a021 | |||
| 44311908 | 172701 | 3 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 176 | 2 | 2 | 3 | 0.9 | Oc1cccc(CC2=NCCN2)c1 | 10.1021/jm970513p | |||
| CHEMBL450281 | 172701 | 3 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 176 | 2 | 2 | 3 | 0.9 | Oc1cccc(CC2=NCCN2)c1 | 10.1021/jm970513p | |||
| 122483281 | 138108 | 0 | None | -741 | 8 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 441 | 7 | 0 | 5 | 5.4 | COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1 | 10.1016/j.ejmech.2016.01.043 | |||
| CHEMBL3763779 | 138108 | 0 | None | -741 | 8 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 441 | 7 | 0 | 5 | 5.4 | COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1 | 10.1016/j.ejmech.2016.01.043 | |||
| CHEMBL3765873 | 138108 | 0 | None | -741 | 8 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 441 | 7 | 0 | 5 | 5.4 | COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1 | 10.1016/j.ejmech.2016.01.043 | |||
| 9994674 | 204156 | 0 | None | -44 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 295 | 5 | 1 | 2 | 4.0 | CCCN(CCC)C1CCc2ccc3[nH]cc(C#N)c3c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL70589 | 204156 | 0 | None | -44 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 295 | 5 | 1 | 2 | 4.0 | CCCN(CCC)C1CCc2ccc3[nH]cc(C#N)c3c2C1 | 10.1021/jm00012a021 | |||
| 44376723 | 119858 | 0 | None | -3 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 436 | 6 | 2 | 3 | 5.3 | S=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)C1CCCCC1 | 10.1016/j.bmcl.2003.11.023 | |||
| CHEMBL348756 | 119858 | 0 | None | -3 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 436 | 6 | 2 | 3 | 5.3 | S=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)C1CCCCC1 | 10.1016/j.bmcl.2003.11.023 | |||
| 24882266 | 188287 | 0 | None | -2 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 812 | 17 | 4 | 4 | 11.6 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | 10.1021/jm7011722 | |||
| CHEMBL500230 | 188287 | 0 | None | -2 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 812 | 17 | 4 | 4 | 11.6 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | 10.1021/jm7011722 | |||
| 59636732 | 126206 | 0 | None | - | 1 | Chinese hamster | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 456 | 7 | 1 | 7 | 3.2 | Cc1ncc(CNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)cn1 | nan | |||
| CHEMBL3650027 | 126206 | 0 | None | - | 1 | Chinese hamster | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 456 | 7 | 1 | 7 | 3.2 | Cc1ncc(CNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)cn1 | nan | |||
| 44403098 | 70272 | 0 | None | 4 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 427 | 4 | 1 | 5 | 2.9 | COc1ccc(NC(=O)N2CCN(c3ccc(F)cc3)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
| CHEMBL194206 | 70272 | 0 | None | 4 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 427 | 4 | 1 | 5 | 2.9 | COc1ccc(NC(=O)N2CCN(c3ccc(F)cc3)CC2)cc1N1CCN(C)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
| 10946905 | 163682 | 0 | None | -43 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 312 | 3 | 2 | 3 | 3.1 | CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCC4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL420475 | 163682 | 0 | None | -43 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 312 | 3 | 2 | 3 | 3.1 | CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCC4)nc23)CC1 | 10.1021/jm030020m | |||
| 10023301 | 18927 | 0 | None | -120 | 2 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 390 | 4 | 0 | 4 | 4.4 | C1=C(CCN2CCN(c3cccc4c3OCCO4)CC2)c2ccccc2CCC1 | 10.1021/jm00020a020 | |||
| CHEMBL128546 | 18927 | 0 | None | -120 | 2 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 390 | 4 | 0 | 4 | 4.4 | C1=C(CCN2CCN(c3cccc4c3OCCO4)CC2)c2ccccc2CCC1 | 10.1021/jm00020a020 | |||
| 14083212 | 63065 | 6 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 204 | 3 | 2 | 2 | 2.1 | COc1ccc2[nH]cc(C[C@@H](C)N)c2c1 | 10.1021/jm00402a026 | |||
| CHEMBL1788281 | 63065 | 6 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 204 | 3 | 2 | 2 | 2.1 | COc1ccc2[nH]cc(C[C@@H](C)N)c2c1 | 10.1021/jm00402a026 | |||
| 10445578 | 120219 | 1 | None | 1 | 3 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 265 | 1 | 0 | 3 | 2.4 | CN1CCN(c2ccc3c(n2)-c2ccccc2C3)CC1 | 10.1021/jm970645i | |||
| CHEMBL352107 | 120219 | 1 | None | 1 | 3 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 265 | 1 | 0 | 3 | 2.4 | CN1CCN(c2ccc3c(n2)-c2ccccc2C3)CC1 | 10.1021/jm970645i | |||
| 10541847 | 102301 | 0 | None | -3 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 294 | 5 | 1 | 3 | 3.4 | Cc1ccc(CC2=NCCN2)c(C)c1OCc1ccccc1 | 10.1021/jm970513p | |||
| CHEMBL303441 | 102301 | 0 | None | -3 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 294 | 5 | 1 | 3 | 3.4 | Cc1ccc(CC2=NCCN2)c(C)c1OCc1ccccc1 | 10.1021/jm970513p | |||
| 49799868 | 10539 | 0 | None | -54 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 419 | 5 | 2 | 3 | 4.2 | NC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CC=C(c2c[nH]c3c(F)cccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
| CHEMBL1169435 | 10539 | 0 | None | -54 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 419 | 5 | 2 | 3 | 4.2 | NC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CC=C(c2c[nH]c3c(F)cccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
| 44342507 | 110189 | 0 | None | -6 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 488 | 4 | 2 | 2 | 6.1 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(/C(S)=N/C45C[C@H]6C[C@@H](C4)C[C@@H](C5)C6)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
| CHEMBL323705 | 110189 | 0 | None | -6 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 488 | 4 | 2 | 2 | 6.1 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(/C(S)=N/C45C[C@H]6C[C@@H](C4)C[C@@H](C5)C6)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
| 49850769 | 56395 | 0 | None | -125 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 429 | 5 | 1 | 4 | 3.8 | Cc1ccc2c(N3CCN(CCc4cccc(N5CCCNC5=O)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| CHEMBL1631541 | 56395 | 0 | None | -125 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 429 | 5 | 1 | 4 | 3.8 | Cc1ccc2c(N3CCN(CCc4cccc(N5CCCNC5=O)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| 49850771 | 56398 | 0 | None | -25 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 428 | 5 | 0 | 5 | 3.6 | Cc1ccc2c(N3CCN(CCc4cccc(N5C(=O)CCC5=O)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| CHEMBL1631544 | 56398 | 0 | None | -25 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 428 | 5 | 0 | 5 | 3.6 | Cc1ccc2c(N3CCN(CCc4cccc(N5C(=O)CCC5=O)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| 10183895 | 93969 | 0 | None | -22 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 473 | 7 | 0 | 5 | 5.0 | Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)N(C(C)C)C(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2007.06.078 | |||
| CHEMBL248456 | 93969 | 0 | None | -22 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 473 | 7 | 0 | 5 | 5.0 | Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)N(C(C)C)C(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2007.06.078 | |||
| 10127149 | 174914 | 0 | None | -6 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 426 | 7 | 0 | 4 | 6.1 | Cc1ccc2c(OCCN3CCC(Cc4cccc(-c5ccoc5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| CHEMBL456460 | 174914 | 0 | None | -6 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 426 | 7 | 0 | 4 | 6.1 | Cc1ccc2c(OCCN3CCC(Cc4cccc(-c5ccoc5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| 10173443 | 175003 | 0 | None | -15 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 429 | 7 | 0 | 4 | 5.5 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCC5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| CHEMBL456684 | 175003 | 0 | None | -15 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 429 | 7 | 0 | 4 | 5.5 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCC5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| 44593711 | 184323 | 0 | None | 1 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 445 | 6 | 1 | 5 | 4.6 | Cc1ccc2c(OCC(C)N3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.110 | |||
| CHEMBL484216 | 184323 | 0 | None | 1 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 445 | 6 | 1 | 5 | 4.6 | Cc1ccc2c(OCC(C)N3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.110 | |||
| 10128059 | 187694 | 0 | None | -6 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 483 | 9 | 1 | 6 | 4.3 | COc1ccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)cc1NS(C)(=O)=O | 10.1021/jm8001444 | |||
| CHEMBL495217 | 187694 | 0 | None | -6 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 483 | 9 | 1 | 6 | 4.3 | COc1ccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)cc1NS(C)(=O)=O | 10.1021/jm8001444 | |||
| 24865543 | 188128 | 0 | None | -31 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 431 | 7 | 0 | 4 | 4.9 | CC(=O)N(C)c1cccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm8001444 | |||
| CHEMBL498356 | 188128 | 0 | None | -31 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 431 | 7 | 0 | 4 | 4.9 | CC(=O)N(C)c1cccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm8001444 | |||
| 22611622 | 4694 | 8 | None | -39 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 271 | 2 | 2 | 2 | 2.9 | CC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2c1 | 10.1021/jm030020m | |||
| CHEMBL103424 | 4694 | 8 | None | -39 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 271 | 2 | 2 | 2 | 2.9 | CC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2c1 | 10.1021/jm030020m | |||
| 11047115 | 5020 | 0 | None | -9 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 379 | 4 | 2 | 5 | 3.5 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccc([N+](=O)[O-])c4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL105118 | 5020 | 0 | None | -9 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 379 | 4 | 2 | 5 | 3.5 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccc([N+](=O)[O-])c4)nc23)CC1 | 10.1021/jm030020m | |||
| 11056946 | 108893 | 0 | None | -54 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 340 | 3 | 2 | 4 | 3.7 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccs4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL321080 | 108893 | 0 | None | -54 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 340 | 3 | 2 | 4 | 3.7 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccs4)nc23)CC1 | 10.1021/jm030020m | |||
| 142601329 | 186517 | 5 | None | -588 | 7 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 276 | 2 | 2 | 3 | 2.5 | Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
| CHEMBL4877603 | 186517 | 5 | None | -588 | 7 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 276 | 2 | 2 | 3 | 2.5 | Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
| 176 | 398 | 66 | None | -10 | 31 | Rat | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
| 2157 | 398 | 66 | None | -10 | 31 | Rat | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
| 2566 | 398 | 66 | None | -10 | 31 | Rat | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
| CHEMBL633 | 398 | 66 | None | -10 | 31 | Rat | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
| DB01118 | 398 | 66 | None | -10 | 31 | Rat | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
| 23533328 | 85176 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 479 | 8 | 2 | 7 | 2.6 | COc1cc(N(C)CCN(C)C)c2[nH]c(C(=O)Nc3ccc(N4CCOCC4)cc3)cc(=O)c2c1 | 10.1016/j.bmc.2006.10.037 | |||
| CHEMBL225308 | 85176 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 479 | 8 | 2 | 7 | 2.6 | COc1cc(N(C)CCN(C)C)c2[nH]c(C(=O)Nc3ccc(N4CCOCC4)cc3)cc(=O)c2c1 | 10.1016/j.bmc.2006.10.037 | |||
| 193381 | 11040 | 21 | None | -1258 | 4 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 261 | 6 | 0 | 2 | 3.7 | CCCN(CCC)C1CCc2cccc(OC)c2C1 | 10.1016/S0960-894X(01)81009-X | |||
| CHEMBL11760 | 11040 | 21 | None | -1258 | 4 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 261 | 6 | 0 | 2 | 3.7 | CCCN(CCC)C1CCc2cccc(OC)c2C1 | 10.1016/S0960-894X(01)81009-X | |||
| 6918647 | 100746 | 2 | None | -79 | 14 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 439 | 5 | 1 | 5 | 3.0 | COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1 | 10.1021/jm980532e | |||
| CHEMBL292759 | 100746 | 2 | None | -79 | 14 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 439 | 5 | 1 | 5 | 3.0 | COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1 | 10.1021/jm980532e | |||
| 10216160 | 67595 | 0 | None | -125 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 400 | 6 | 1 | 4 | 4.2 | Cc1ccc2c(OCCN3CCN(Cc4cccc5cc[nH]c45)CC3)cccc2n1 | 10.1021/jm049039v | |||
| CHEMBL190190 | 67595 | 0 | None | -125 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 400 | 6 | 1 | 4 | 4.2 | Cc1ccc2c(OCCN3CCN(Cc4cccc5cc[nH]c45)CC3)cccc2n1 | 10.1021/jm049039v | |||
| 11464355 | 127233 | 0 | None | -39 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 422 | 7 | 1 | 7 | 3.4 | Cc1ccc2c(OCCN3CCN(Cc4ccc(O)c([N+](=O)[O-])c4)CC3)cccc2n1 | 10.1021/jm049039v | |||
| CHEMBL365810 | 127233 | 0 | None | -39 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 422 | 7 | 1 | 7 | 3.4 | Cc1ccc2c(OCCN3CCN(Cc4ccc(O)c([N+](=O)[O-])c4)CC3)cccc2n1 | 10.1021/jm049039v | |||
| 11178830 | 148126 | 0 | None | -251 | 9 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 467 | 6 | 1 | 5 | 4.5 | Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(F)cc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
| CHEMBL393539 | 148126 | 0 | None | -251 | 9 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 467 | 6 | 1 | 5 | 4.5 | Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(F)cc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
| 44588742 | 191249 | 0 | None | -2 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 419 | 7 | 1 | 6 | 3.4 | Cc1ccc2c(OCCCN3CC(Oc4ccc5c(c4)NC(=O)CO5)C3)cccc2n1 | 10.1016/j.bmcl.2008.08.110 | |||
| CHEMBL519019 | 191249 | 0 | None | -2 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 419 | 7 | 1 | 6 | 3.4 | Cc1ccc2c(OCCCN3CC(Oc4ccc5c(c4)NC(=O)CO5)C3)cccc2n1 | 10.1016/j.bmcl.2008.08.110 | |||
| 10423801 | 27628 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 280 | 1 | 0 | 4 | 2.5 | Cc1cccc2nc(N3CCN(C)CC3)c3cccn3c12 | 10.1021/jm990151g | |||
| CHEMBL136978 | 27628 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 280 | 1 | 0 | 4 | 2.5 | Cc1cccc2nc(N3CCN(C)CC3)c3cccn3c12 | 10.1021/jm990151g | |||
| 10249573 | 207593 | 0 | None | -398 | 11 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 386 | 5 | 0 | 3 | 4.1 | CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1 | 10.1021/jm991151j | |||
| CHEMBL94984 | 207593 | 0 | None | -398 | 11 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 386 | 5 | 0 | 3 | 4.1 | CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1 | 10.1021/jm991151j | |||
| 10689158 | 116675 | 0 | None | - | 1 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 349 | 3 | 0 | 6 | 3.3 | c1csc(CN2CCN(c3nc4cccnc4n4cccc34)CC2)c1 | 10.1021/jm990151g | |||
| CHEMBL337101 | 116675 | 0 | None | - | 1 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 349 | 3 | 0 | 6 | 3.3 | c1csc(CN2CCN(c3nc4cccnc4n4cccc34)CC2)c1 | 10.1021/jm990151g | |||
| 9892409 | 100950 | 0 | None | -794 | 9 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 505 | 5 | 1 | 6 | 5.3 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCCCC2C1 | 10.1016/s0960-894x(02)00172-5 | |||
| CHEMBL29410 | 100950 | 0 | None | -794 | 9 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 505 | 5 | 1 | 6 | 5.3 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCCCC2C1 | 10.1016/s0960-894x(02)00172-5 | |||
| 108029 | 3414 | 57 | None | -3 | 13 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 228 | 2 | 2 | 2 | 2.6 | COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1 | 10.1021/jm00384a001 | |||
| 23 | 3414 | 57 | None | -3 | 13 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 228 | 2 | 2 | 2 | 2.6 | COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1 | 10.1021/jm00384a001 | |||
| CHEMBL18785 | 3414 | 57 | None | -3 | 13 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 228 | 2 | 2 | 2 | 2.6 | COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1 | 10.1021/jm00384a001 | |||
| 14479837 | 207511 | 7 | None | 2 | 3 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 234 | 5 | 1 | 3 | 2.3 | CCCCOc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
| CHEMBL9452 | 207511 | 7 | None | 2 | 3 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 234 | 5 | 1 | 3 | 2.3 | CCCCOc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
| 5 | 139 | 72 | None | -11 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2013.01.044 | |||
| 5202 | 139 | 72 | None | -11 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2013.01.044 | |||
| CHEMBL39 | 139 | 72 | None | -11 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2013.01.044 | |||
| DB08839 | 139 | 72 | None | -11 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2013.01.044 | |||
| 5 | 139 | 72 | None | -11 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm950498t | |||
| 5202 | 139 | 72 | None | -11 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm950498t | |||
| CHEMBL39 | 139 | 72 | None | -11 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm950498t | |||
| DB08839 | 139 | 72 | None | -11 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm950498t | |||
| 5 | 139 | 72 | None | -11 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00044a001 | |||
| 5202 | 139 | 72 | None | -11 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00044a001 | |||
| CHEMBL39 | 139 | 72 | None | -11 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00044a001 | |||
| DB08839 | 139 | 72 | None | -11 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00044a001 | |||
| 107 | 141 | 121 | None | -30 | 30 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10.1021/jm00399a031 | |||
| 1833 | 141 | 121 | None | -30 | 30 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10.1021/jm00399a031 | |||
| CHEMBL8165 | 141 | 121 | None | -30 | 30 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10.1021/jm00399a031 | |||
| 10972931 | 208065 | 0 | None | 8 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 484 | 6 | 1 | 5 | 4.4 | O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4cncnc4)cc23)CC1 | 10.1021/jm020938y | |||
| CHEMBL97650 | 208065 | 0 | None | 8 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 484 | 6 | 1 | 5 | 4.4 | O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4cncnc4)cc23)CC1 | 10.1021/jm020938y | |||
| 44342830 | 167981 | 0 | None | -10 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 444 | 5 | 2 | 3 | 5.1 | COc1ccc(NC(=O)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1 | 10.1016/s0960-894x(03)00779-0 | |||
| CHEMBL431866 | 167981 | 0 | None | -10 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 444 | 5 | 2 | 3 | 5.1 | COc1ccc(NC(=O)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1 | 10.1016/s0960-894x(03)00779-0 | |||
| 2869 | 4152 | 89 | None | -8 | 7 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1016/s0960-894x(98)00090-0 | |||
| 60 | 4152 | 89 | None | -8 | 7 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1016/s0960-894x(98)00090-0 | |||
| 60857 | 4152 | 89 | None | -8 | 7 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1016/s0960-894x(98)00090-0 | |||
| CHEMBL1185 | 4152 | 89 | None | -8 | 7 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1016/s0960-894x(98)00090-0 | |||
| DB00315 | 4152 | 89 | None | -8 | 7 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10.1016/s0960-894x(98)00090-0 | |||
| 11384146 | 201733 | 0 | None | -10 | 9 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 403 | 5 | 2 | 3 | 4.3 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3cccc(Cl)c3)cc12 | 10.1021/jm049243i | |||
| CHEMBL606556 | 201733 | 0 | None | -10 | 9 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 403 | 5 | 2 | 3 | 4.3 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3cccc(Cl)c3)cc12 | 10.1021/jm049243i | |||
| 107780 | 1844 | 54 | None | 1 | 17 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1016/j.bmcl.2005.07.024 | |||
| 14 | 1844 | 54 | None | 1 | 17 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1016/j.bmcl.2005.07.024 | |||
| CHEMBL15928 | 1844 | 54 | None | 1 | 17 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1016/j.bmcl.2005.07.024 | |||
| 1355 | 2011 | 88 | None | -1 | 16 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 196 | 1 | 1 | 2 | 1.8 | Clc1cccc(c1)N1CCNCC1 | 10.1021/jm00125a020 | |||
| 142 | 2011 | 88 | None | -1 | 16 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 196 | 1 | 1 | 2 | 1.8 | Clc1cccc(c1)N1CCNCC1 | 10.1021/jm00125a020 | |||
| CHEMBL478 | 2011 | 88 | None | -1 | 16 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 196 | 1 | 1 | 2 | 1.8 | Clc1cccc(c1)N1CCNCC1 | 10.1021/jm00125a020 | |||
| DB12110 | 2011 | 88 | None | -1 | 16 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 196 | 1 | 1 | 2 | 1.8 | Clc1cccc(c1)N1CCNCC1 | 10.1021/jm00125a020 | |||
| 59636780 | 125692 | 0 | None | - | 1 | Chinese hamster | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 404 | 5 | 0 | 5 | 3.4 | O=C(c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1)N1CCCC1 | nan | |||
| CHEMBL3647274 | 125692 | 0 | None | - | 1 | Chinese hamster | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 404 | 5 | 0 | 5 | 3.4 | O=C(c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1)N1CCCC1 | nan | |||
| 1588 | 2325 | 27 | None | -58 | 44 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | nan | |||
| 28864 | 2325 | 27 | None | -58 | 44 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | nan | |||
| 43 | 2325 | 27 | None | -58 | 44 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | nan | |||
| CHEMBL157138 | 2325 | 27 | None | -58 | 44 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | nan | |||
| DB00589 | 2325 | 27 | None | -58 | 44 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | nan | |||
| 10751317 | 8649 | 21 | None | 19 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 218 | 5 | 2 | 2 | 2.5 | CCCOc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
| CHEMBL109526 | 8649 | 21 | None | 19 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 218 | 5 | 2 | 2 | 2.5 | CCCOc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
| 5 | 139 | 72 | None | -11 | 54 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm020938y | |||
| 5202 | 139 | 72 | None | -11 | 54 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm020938y | |||
| CHEMBL39 | 139 | 72 | None | -11 | 54 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm020938y | |||
| DB08839 | 139 | 72 | None | -11 | 54 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm020938y | |||
| 44342722 | 110543 | 0 | None | -10 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 414 | 4 | 2 | 2 | 5.1 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(C(=O)Nc4ccccc4)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
| CHEMBL325175 | 110543 | 0 | None | -10 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 414 | 4 | 2 | 2 | 5.1 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(C(=O)Nc4ccccc4)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
| 19066235 | 11385 | 0 | None | 75 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 437 | 6 | 1 | 6 | 2.5 | COc1ccc(NCC(=O)N2CCN(c3ccccc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL110601 | 11385 | 0 | None | 75 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 437 | 6 | 1 | 6 | 2.5 | COc1ccc(NCC(=O)N2CCN(c3ccccc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL1180011 | 11385 | 0 | None | 75 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 437 | 6 | 1 | 6 | 2.5 | COc1ccc(NCC(=O)N2CCN(c3ccccc3C)CC2)cc1N1CCN(C)CC1 | 10.1016/S0960-894X(97)10164-0 | |||
| 44376516 | 56384 | 0 | None | -4 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 414 | 6 | 2 | 3 | 4.2 | O=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)c1ccccc1 | 10.1016/j.bmcl.2003.11.023 | |||
| CHEMBL163151 | 56384 | 0 | None | -4 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 414 | 6 | 2 | 3 | 4.2 | O=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)c1ccccc1 | 10.1016/j.bmcl.2003.11.023 | |||
| 2105 | 3054 | 37 | None | -27 | 33 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | nan | |||
| 47811 | 3054 | 37 | None | -27 | 33 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | nan | |||
| 48 | 3054 | 37 | None | -27 | 33 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | nan | |||
| CHEMBL531 | 3054 | 37 | None | -27 | 33 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | nan | |||
| DB01186 | 3054 | 37 | None | -27 | 33 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | nan | |||
| 10782681 | 109467 | 0 | None | 1 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 330 | 12 | 1 | 2 | 5.4 | CCCCCCCCCOc1ccc2[nH]cc(CCN(C)C)c2c1 | 10.1021/jm950498t | |||
| CHEMBL322054 | 109467 | 0 | None | 1 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 330 | 12 | 1 | 2 | 5.4 | CCCCCCCCCOc1ccc2[nH]cc(CCN(C)C)c2c1 | 10.1021/jm950498t | |||
| 11740280 | 102926 | 0 | None | -15 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 376 | 8 | 1 | 2 | 5.4 | CCCN(CCCc1ccccc1OC)C1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL306197 | 102926 | 0 | None | -15 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 376 | 8 | 1 | 2 | 5.4 | CCCN(CCCc1ccccc1OC)C1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
| 107 | 141 | 121 | None | -30 | 30 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10.1021/jm00384a001 | |||
| 1833 | 141 | 121 | None | -30 | 30 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10.1021/jm00384a001 | |||
| CHEMBL8165 | 141 | 121 | None | -30 | 30 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10.1021/jm00384a001 | |||
| 161 | 754 | 6 | None | -16 | 6 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 286 | 5 | 2 | 3 | 3.7 | CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N | nan | |||
| 4284720 | 754 | 6 | None | -16 | 6 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 286 | 5 | 2 | 3 | 3.7 | CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N | nan | |||
| CHEMBL1255834 | 754 | 6 | None | -16 | 6 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 286 | 5 | 2 | 3 | 3.7 | CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N | nan | |||
| 14083214 | 60324 | 2 | None | - | 1 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 190 | 2 | 3 | 2 | 1.8 | C[C@H](N)Cc1c[nH]c2cccc(O)c12 | 10.1021/jm00402a026 | |||
| CHEMBL1744074 | 60324 | 2 | None | - | 1 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 190 | 2 | 3 | 2 | 1.8 | C[C@H](N)Cc1c[nH]c2cccc(O)c12 | 10.1021/jm00402a026 | |||
| 441383 | 20333 | 57 | None | -19 | 16 | Rat | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 531 | 8 | 0 | 8 | 4.5 | CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | nan | |||
| CHEMBL1306 | 20333 | 57 | None | -19 | 16 | Rat | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 531 | 8 | 0 | 8 | 4.5 | CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | nan | |||
| 10247448 | 204389 | 0 | None | -7 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 352 | 6 | 1 | 1 | 5.3 | CCCN(CCC)C1CCc2ccc3[nH]cc(CC(F)(F)F)c3c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL71899 | 204389 | 0 | None | -7 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 352 | 6 | 1 | 1 | 5.3 | CCCN(CCC)C1CCc2ccc3[nH]cc(CC(F)(F)F)c3c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL5077293 | 214491 | 0 | None | -144 | 9 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | None | None | None | COc1ccccc1-c1cc(C2CCNC2)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||||
| 44376491 | 55490 | 0 | None | -15 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 485 | 6 | 1 | 3 | 5.4 | O=S(=O)(c1cccc2ccccc12)N1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1 | 10.1016/j.bmcl.2003.11.023 | |||
| CHEMBL162011 | 55490 | 0 | None | -15 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 485 | 6 | 1 | 3 | 5.4 | O=S(=O)(c1cccc2ccccc12)N1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1 | 10.1016/j.bmcl.2003.11.023 | |||
| 73346042 | 91834 | 5 | None | -4073 | 17 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 405 | 9 | 0 | 8 | 0.9 | Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O | 10.1016/j.bmc.2013.05.050 | |||
| CHEMBL2413153 | 91834 | 5 | None | -4073 | 17 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 405 | 9 | 0 | 8 | 0.9 | Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O | 10.1016/j.bmc.2013.05.050 | |||
| 44438462 | 90974 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 506 | 6 | 0 | 6 | 6.0 | CC1CC(N2CCN(C3CCc4ccc(OCc5noc(-c6ccc(Cl)cc6)n5)cc43)CC2)CC1C | 10.1016/j.bmcl.2006.12.109 | |||
| CHEMBL239598 | 90974 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 506 | 6 | 0 | 6 | 6.0 | CC1CC(N2CCN(C3CCc4ccc(OCc5noc(-c6ccc(Cl)cc6)n5)cc43)CC2)CC1C | 10.1016/j.bmcl.2006.12.109 | |||
| 182596 | 118486 | 16 | None | -269 | 3 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 364 | 4 | 0 | 4 | 3.7 | c1ccc2c(c1)CCC2CCN1CCN(c2cccc3c2OCCO3)CC1 | 10.1021/jm00020a020 | |||
| CHEMBL341391 | 118486 | 16 | None | -269 | 3 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 364 | 4 | 0 | 4 | 3.7 | c1ccc2c(c1)CCC2CCN1CCN(c2cccc3c2OCCO3)CC1 | 10.1021/jm00020a020 | |||
| 14083211 | 77865 | 6 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 204 | 3 | 2 | 2 | 2.1 | COc1ccc2[nH]cc(C[C@H](C)N)c2c1 | 10.1021/jm00402a026 | |||
| CHEMBL2093088 | 77865 | 6 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 204 | 3 | 2 | 2 | 2.1 | COc1ccc2[nH]cc(C[C@H](C)N)c2c1 | 10.1021/jm00402a026 | |||
| 76330157 | 106247 | 0 | None | -1 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 233 | 4 | 1 | 2 | 3.0 | CNC(C)COc1ccc(Cl)cc1Cl | 10.1007/s00044-009-9164-1 | |||
| CHEMBL2260926 | 106247 | 0 | None | -1 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 233 | 4 | 1 | 2 | 3.0 | CNC(C)COc1ccc(Cl)cc1Cl | 10.1007/s00044-009-9164-1 | |||
| CHEMBL3138918 | 106247 | 0 | None | -1 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 233 | 4 | 1 | 2 | 3.0 | CNC(C)COc1ccc(Cl)cc1Cl | 10.1007/s00044-009-9164-1 | |||
| 59636715 | 125690 | 0 | None | - | 1 | Chinese hamster | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 440 | 6 | 1 | 5 | 3.7 | O=C(NC1CC(F)(F)C1)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| CHEMBL3647272 | 125690 | 0 | None | - | 1 | Chinese hamster | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 440 | 6 | 1 | 5 | 3.7 | O=C(NC1CC(F)(F)C1)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| 9796627 | 96653 | 0 | None | -14 | 7 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 308 | 4 | 1 | 4 | 3.1 | CN(C)CCc1cn(C(=O)c2ccccc2)c2ccc(O)cc12 | 10.1021/jm010943m | |||
| CHEMBL263700 | 96653 | 0 | None | -14 | 7 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 308 | 4 | 1 | 4 | 3.1 | CN(C)CCc1cn(C(=O)c2ccccc2)c2ccc(O)cc12 | 10.1021/jm010943m | |||
| 10359357 | 200500 | 1 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 331 | 1 | 1 | 4 | 3.2 | c1ccc2c(c1)OCCc1c(N3CCNCC3)nc3ccccc3c1-2 | 10.1021/jm00014a021 | |||
| CHEMBL59871 | 200500 | 1 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 331 | 1 | 1 | 4 | 3.2 | c1ccc2c(c1)OCCc1c(N3CCNCC3)nc3ccccc3c1-2 | 10.1021/jm00014a021 | |||
| 169764 | 33114 | 8 | None | -602 | 2 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 260 | 7 | 2 | 2 | 3.5 | CCCN(CCC)CCc1c[nH]c2ccc(O)cc12 | 10.1021/jm00399a031 | |||
| CHEMBL141706 | 33114 | 8 | None | -602 | 2 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 260 | 7 | 2 | 2 | 3.5 | CCCN(CCC)CCc1c[nH]c2ccc(O)cc12 | 10.1021/jm00399a031 | |||
| 135398745 | 2914 | 112 | None | -162 | 65 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | nan | |||
| 47 | 2914 | 112 | None | -162 | 65 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | nan | |||
| CHEMBL715 | 2914 | 112 | None | -162 | 65 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | nan | |||
| DB00334 | 2914 | 112 | None | -162 | 65 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | nan | |||
| 10403260 | 204286 | 0 | None | -10 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 312 | 6 | 0 | 3 | 4.0 | CCCN(CCC)C1CCc2ccc3c(c(C=O)cn3C)c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL71299 | 204286 | 0 | None | -10 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 312 | 6 | 0 | 3 | 4.0 | CCCN(CCC)C1CCc2ccc3c(c(C=O)cn3C)c2C1 | 10.1021/jm00012a021 | |||
| 44376262 | 167097 | 0 | None | -5 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 444 | 7 | 2 | 4 | 4.2 | COc1ccc(C(=O)NN2CC=C(c3ccc4[nH]cc(CCN5CCCC5)c4c3)CC2)cc1 | 10.1016/j.bmcl.2003.11.023 | |||
| CHEMBL428991 | 167097 | 0 | None | -5 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 444 | 7 | 2 | 4 | 4.2 | COc1ccc(C(=O)NN2CC=C(c3ccc4[nH]cc(CCN5CCCC5)c4c3)CC2)cc1 | 10.1016/j.bmcl.2003.11.023 | |||
| 59636739 | 126205 | 0 | None | - | 1 | Chinese hamster | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 469 | 7 | 1 | 6 | 4.4 | Cc1ccc(C(C)NC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)cn1 | nan | |||
| CHEMBL3650026 | 126205 | 0 | None | - | 1 | Chinese hamster | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 469 | 7 | 1 | 6 | 4.4 | Cc1ccc(C(C)NC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)cn1 | nan | |||
| 91965 | 208030 | 96 | None | 1 | 2 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 176 | 1 | 1 | 2 | 1.4 | Cc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
| CHEMBL9746 | 208030 | 96 | None | 1 | 2 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 176 | 1 | 1 | 2 | 1.4 | Cc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
| 9954663 | 56524 | 0 | None | -20 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 435 | 6 | 1 | 3 | 4.3 | O=S(=O)(c1ccccc1)N1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1 | 10.1016/j.bmcl.2003.11.023 | |||
| CHEMBL163639 | 56524 | 0 | None | -20 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 435 | 6 | 1 | 3 | 4.3 | O=S(=O)(c1ccccc1)N1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1 | 10.1016/j.bmcl.2003.11.023 | |||
| 44395809 | 123104 | 0 | None | -91 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 353 | 3 | 1 | 3 | 3.5 | CN1CCC(N2CCc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| CHEMBL361061 | 123104 | 0 | None | -91 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 353 | 3 | 1 | 3 | 3.5 | CN1CCC(N2CCc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| 9881603 | 123296 | 0 | None | -134 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 258 | 2 | 1 | 2 | 3.5 | Cc1cc(C(C)(C)C)cc(C)c1CC1=NCCCN1 | 10.1016/j.bmcl.2004.06.085 | |||
| CHEMBL361470 | 123296 | 0 | None | -134 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 258 | 2 | 1 | 2 | 3.5 | Cc1cc(C(C)(C)C)cc(C)c1CC1=NCCCN1 | 10.1016/j.bmcl.2004.06.085 | |||
| 10563980 | 199669 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 270 | 3 | 1 | 4 | 1.9 | N#CC1=Cc2cccc(OCC3CNCCO3)c2CC1 | 10.1021/jm970806i | |||
| CHEMBL59300 | 199669 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 270 | 3 | 1 | 4 | 1.9 | N#CC1=Cc2cccc(OCC3CNCCO3)c2CC1 | 10.1021/jm970806i | |||
| 11812916 | 112327 | 0 | None | 1 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 486 | 6 | 1 | 5 | 4.4 | Cn1cc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)cn1 | 10.1021/jm020938y | |||
| CHEMBL329280 | 112327 | 0 | None | 1 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 486 | 6 | 1 | 5 | 4.4 | Cn1cc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)cn1 | 10.1021/jm020938y | |||
| 150885 | 98663 | 34 | None | -8 | 3 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 190 | 3 | 3 | 2 | 1.6 | CNCCc1c[nH]c2ccc(O)cc12 | 10.1021/jm00384a001 | |||
| CHEMBL1256286 | 98663 | 34 | None | -8 | 3 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 190 | 3 | 3 | 2 | 1.6 | CNCCc1c[nH]c2ccc(O)cc12 | 10.1021/jm00384a001 | |||
| CHEMBL277362 | 98663 | 34 | None | -8 | 3 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 190 | 3 | 3 | 2 | 1.6 | CNCCc1c[nH]c2ccc(O)cc12 | 10.1021/jm00384a001 | |||
| 15124076 | 45845 | 0 | None | -40 | 3 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 438 | 8 | 0 | 5 | 4.0 | CCC(C)Oc1ccccc1N1CCN(Cc2ccc(CN3CCCCC3=O)n2C)CC1 | 10.1021/jm00081a018 | |||
| CHEMBL153136 | 45845 | 0 | None | -40 | 3 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 438 | 8 | 0 | 5 | 4.0 | CCC(C)Oc1ccccc1N1CCN(Cc2ccc(CN3CCCCC3=O)n2C)CC1 | 10.1021/jm00081a018 | |||
| 6603907 | 33015 | 9 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 190 | 2 | 3 | 2 | 1.8 | C[C@H](N)Cc1c[nH]c2ccc(O)cc12 | 10.1021/jm00402a026 | |||
| CHEMBL1416204 | 33015 | 9 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 190 | 2 | 3 | 2 | 1.8 | C[C@H](N)Cc1c[nH]c2ccc(O)cc12 | 10.1021/jm00402a026 | |||
| 24881687 | 172814 | 0 | None | -3 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 776 | 10 | 4 | 4 | 10.2 | O=C(Nc1ccc2[nH]cc(C3CCN(Cc4cccc(CN5CCC(c6c[nH]c7ccc(NC(=O)c8ccc(F)cc8)cc67)CC5)c4)CC3)c2c1)c1ccc(F)cc1 | 10.1021/jm7011722 | |||
| CHEMBL451394 | 172814 | 0 | None | -3 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 776 | 10 | 4 | 4 | 10.2 | O=C(Nc1ccc2[nH]cc(C3CCN(Cc4cccc(CN5CCC(c6c[nH]c7ccc(NC(=O)c8ccc(F)cc8)cc67)CC5)c4)CC3)c2c1)c1ccc(F)cc1 | 10.1021/jm7011722 | |||
| 10406614 | 204416 | 0 | None | -457 | 5 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 366 | 7 | 1 | 3 | 4.9 | CCCN(CCc1cccs1)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL72062 | 204416 | 0 | None | -457 | 5 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 366 | 7 | 1 | 3 | 4.9 | CCCN(CCc1cccs1)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| 10064500 | 204159 | 0 | None | -2398 | 5 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 318 | 5 | 1 | 1 | 4.9 | CCCN(Cc1ccccc1)C1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL70606 | 204159 | 0 | None | -2398 | 5 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 318 | 5 | 1 | 1 | 4.9 | CCCN(Cc1ccccc1)C1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
| 9955015 | 63094 | 5 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 346 | 5 | 1 | 6 | 1.2 | C1=C(CN2CCOCC2)COc2c1cccc2OC[C@H]1CNCCO1 | 10.1021/jm970806i | |||
| CHEMBL1744087 | 63094 | 5 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 346 | 5 | 1 | 6 | 1.2 | C1=C(CN2CCOCC2)COc2c1cccc2OC[C@H]1CNCCO1 | 10.1021/jm970806i | |||
| CHEMBL1789131 | 63094 | 5 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 346 | 5 | 1 | 6 | 1.2 | C1=C(CN2CCOCC2)COc2c1cccc2OC[C@H]1CNCCO1 | 10.1021/jm970806i | |||
| CHEMBL5276321 | 193894 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 346 | 5 | 1 | 6 | 1.2 | C1=C(CN2CCOCC2)COc2c1cccc2OCC1COCCN1 | 10.1016/j.ejmech.2016.07.057 | |||
| 10131024 | 176161 | 16 | None | -47 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 242 | 3 | 1 | 1 | 3.4 | CCc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1 | 10.1016/s0960-894x(00)00322-x | |||
| CHEMBL45929 | 176161 | 16 | None | -47 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 242 | 3 | 1 | 1 | 3.4 | CCc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1 | 10.1016/s0960-894x(00)00322-x | |||
| 31101 | 729 | 40 | None | -48 | 36 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | nan | |||
| 35 | 729 | 40 | None | -48 | 36 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | nan | |||
| 403 | 729 | 40 | None | -48 | 36 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | nan | |||
| CHEMBL493 | 729 | 40 | None | -48 | 36 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | nan | |||
| DB01200 | 729 | 40 | None | -48 | 36 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | nan | |||
| 2543 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(00)00322-x | |||
| 5358 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(00)00322-x | |||
| 54 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(00)00322-x | |||
| CHEMBL128 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(00)00322-x | |||
| DB00669 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(00)00322-x | |||
| 135 | 2532 | 43 | None | -851 | 58 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1021/jm00384a001 | |||
| 1796 | 2532 | 43 | None | -851 | 58 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1021/jm00384a001 | |||
| 4184 | 2532 | 43 | None | -851 | 58 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1021/jm00384a001 | |||
| CHEMBL6437 | 2532 | 43 | None | -851 | 58 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1021/jm00384a001 | |||
| DB06148 | 2532 | 43 | None | -851 | 58 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1021/jm00384a001 | |||
| 10912152 | 101453 | 0 | None | -89 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 256 | 4 | 1 | 1 | 3.9 | CC(C)c1ccc2[nH]cc(CCN3CCCC3)c2c1 | 10.1016/s0960-894x(00)00322-x | |||
| CHEMBL297660 | 101453 | 0 | None | -89 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 256 | 4 | 1 | 1 | 3.9 | CC(C)c1ccc2[nH]cc(CCN3CCCC3)c2c1 | 10.1016/s0960-894x(00)00322-x | |||
| 44383728 | 165346 | 1 | None | -15 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 330 | 4 | 1 | 2 | 5.2 | Clc1ccc(-c2ccc3[nH]cc(CCN4CCCC4)c3c2)s1 | 10.1016/s0960-894x(00)00133-5 | |||
| CHEMBL423610 | 165346 | 1 | None | -15 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 330 | 4 | 1 | 2 | 5.2 | Clc1ccc(-c2ccc3[nH]cc(CCN4CCCC4)c3c2)s1 | 10.1016/s0960-894x(00)00133-5 | |||
| 9826801 | 107937 | 0 | None | -208 | 11 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 488 | 6 | 1 | 7 | 3.2 | Cn1nnc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | |||
| CHEMBL319352 | 107937 | 0 | None | -208 | 11 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 488 | 6 | 1 | 7 | 3.2 | Cn1nnc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | |||
| 11016418 | 106122 | 0 | None | -776 | 8 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 488 | 6 | 0 | 7 | 4.2 | Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCN4CCOC4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | |||
| CHEMBL313424 | 106122 | 0 | None | -776 | 8 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 488 | 6 | 0 | 7 | 4.2 | Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCN4CCOC4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | |||
| 2470 | 3653 | 50 | None | -43651 | 59 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm00384a001 | |||
| 3300 | 3653 | 50 | None | -43651 | 59 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm00384a001 | |||
| 5265 | 3653 | 50 | None | -43651 | 59 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm00384a001 | |||
| 99 | 3653 | 50 | None | -43651 | 59 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm00384a001 | |||
| CHEMBL267930 | 3653 | 50 | None | -43651 | 59 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm00384a001 | |||
| 71062768 | 143736 | 0 | None | -12 | 4 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 382 | 6 | 0 | 5 | 2.4 | COc1cccc(OC[C@@H]2CN(CC(=O)N3CCc4ccccc43)CCO2)c1 | nan | |||
| CHEMBL3900699 | 143736 | 0 | None | -12 | 4 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 382 | 6 | 0 | 5 | 2.4 | COc1cccc(OC[C@@H]2CN(CC(=O)N3CCc4ccccc43)CCO2)c1 | nan | |||
| 10376496 | 102899 | 0 | None | -147 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 228 | 3 | 2 | 1 | 3.0 | CCCNC1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL305976 | 102899 | 0 | None | -147 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 228 | 3 | 2 | 1 | 3.0 | CCCNC1CCc2ccc3[nH]ccc3c2C1 | 10.1021/jm00012a022 | |||
| 192260 | 77244 | 7 | None | -34 | 2 | Rat | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 245 | 3 | 0 | 2 | 3.1 | CCCN1CC[C@H]2c3c(cccc3OC)C[C@H]2C1 | 10.1021/jm00027a013 | |||
| CHEMBL2079597 | 77244 | 7 | None | -34 | 2 | Rat | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 245 | 3 | 0 | 2 | 3.1 | CCCN1CC[C@H]2c3c(cccc3OC)C[C@H]2C1 | 10.1021/jm00027a013 | |||
| 44582678 | 181574 | 0 | None | -33 | 10 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 401 | 9 | 1 | 4 | 4.3 | COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | |||
| CHEMBL476839 | 181574 | 0 | None | -33 | 10 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 401 | 9 | 1 | 4 | 4.3 | COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | |||
| 9998026 | 115384 | 0 | None | -173 | 2 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 350 | 3 | 0 | 4 | 3.0 | c1ccc2c(c1)CC(CN1CCN(c3cccc4c3OCCO4)CC1)C2 | 10.1021/jm00020a020 | |||
| CHEMBL335010 | 115384 | 0 | None | -173 | 2 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 350 | 3 | 0 | 4 | 3.0 | c1ccc2c(c1)CC(CN1CCN(c3cccc4c3OCCO4)CC1)C2 | 10.1021/jm00020a020 | |||
| 10379833 | 102739 | 0 | None | -162 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 296 | 6 | 1 | 2 | 3.7 | C=CCN(CCC)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL304984 | 102739 | 0 | None | -162 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 296 | 6 | 1 | 2 | 3.7 | C=CCN(CCC)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| 1809 | 134 | 32 | None | -32 | 36 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm00384a001 | |||
| 4 | 134 | 32 | None | -32 | 36 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm00384a001 | |||
| CHEMBL18840 | 134 | 32 | None | -32 | 36 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm00384a001 | |||
| 5 | 139 | 72 | None | -13 | 54 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00164a046 | |||
| 5202 | 139 | 72 | None | -13 | 54 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00164a046 | |||
| CHEMBL39 | 139 | 72 | None | -13 | 54 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00164a046 | |||
| DB08839 | 139 | 72 | None | -13 | 54 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00164a046 | |||
| 59636778 | 126224 | 0 | None | - | 1 | Chinese hamster | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 478 | 5 | 0 | 5 | 3.5 | CC(=O)N1CCc2cc(CCN3CCN(c4cc(F)cc5cc(C(=O)N(C)C)oc45)CC3)ccc21 | nan | |||
| CHEMBL3650044 | 126224 | 0 | None | - | 1 | Chinese hamster | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 478 | 5 | 0 | 5 | 3.5 | CC(=O)N1CCc2cc(CCN3CCN(c4cc(F)cc5cc(C(=O)N(C)C)oc45)CC3)ccc21 | nan | |||
| 44402894 | 98209 | 0 | None | 3 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 551 | 5 | 0 | 7 | 5.8 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)c1ccc(-c3ccc(-c4noc(C)n4)cc3C)cc1)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| CHEMBL274256 | 98209 | 0 | None | 3 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 551 | 5 | 0 | 7 | 5.8 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)c1ccc(-c3ccc(-c4noc(C)n4)cc3C)cc1)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| 44402895 | 124552 | 0 | None | 50 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 533 | 5 | 1 | 6 | 5.5 | COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(C(=O)c1ccc(-c3ccc(-c4ncccn4)cc3C)cc1)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| CHEMBL364056 | 124552 | 0 | None | 50 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 533 | 5 | 1 | 6 | 5.5 | COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(C(=O)c1ccc(-c3ccc(-c4ncccn4)cc3C)cc1)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| 9871977 | 166094 | 0 | None | 79 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 539 | 5 | 1 | 6 | 4.6 | COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(C(=O)c1ccc(-c3ccc(N4CCCC4=O)nc3C)cc1)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| CHEMBL425919 | 166094 | 0 | None | 79 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 539 | 5 | 1 | 6 | 4.6 | COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(C(=O)c1ccc(-c3ccc(N4CCCC4=O)nc3C)cc1)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| 5 | 139 | 72 | None | -11 | 54 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm0341204 | |||
| 5202 | 139 | 72 | None | -11 | 54 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm0341204 | |||
| CHEMBL39 | 139 | 72 | None | -11 | 54 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm0341204 | |||
| DB08839 | 139 | 72 | None | -11 | 54 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm0341204 | |||
| 49850980 | 56465 | 0 | None | -12 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 468 | 6 | 1 | 4 | 5.3 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccc(F)cc5)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| CHEMBL1632213 | 56465 | 0 | None | -12 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 468 | 6 | 1 | 4 | 5.3 | Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccc(F)cc5)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| 9957376 | 176157 | 0 | None | -25 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 457 | 7 | 0 | 4 | 5.7 | Cc1ccc2c(OCCN3CCC(Cc4cccc(C5CCN(C)CC5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| CHEMBL459282 | 176157 | 0 | None | -25 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 457 | 7 | 0 | 4 | 5.7 | Cc1ccc2c(OCCN3CCC(Cc4cccc(C5CCN(C)CC5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| 17947861 | 71450 | 1 | None | 1 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 444 | 2 | 0 | 6 | 2.9 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2cnn(C)c2C(F)(F)F)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
| CHEMBL196140 | 71450 | 1 | None | 1 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 444 | 2 | 0 | 6 | 2.9 | CN1CCN(c2nccc3cc4c(cc23)N(C(=O)c2cnn(C)c2C(F)(F)F)CC4)CC1 | 10.1016/j.bmcl.2005.06.042 | |||
| 134551 | 358 | 27 | None | -5 | 21 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 575 | 5 | 3 | 6 | 2.4 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C | nan | |||
| 271 | 358 | 27 | None | -5 | 21 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 575 | 5 | 3 | 6 | 2.4 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C | nan | |||
| 885 | 358 | 27 | None | -5 | 21 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 575 | 5 | 3 | 6 | 2.4 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C | nan | |||
| CHEMBL1403281 | 358 | 27 | None | -5 | 21 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 575 | 5 | 3 | 6 | 2.4 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C | nan | |||
| 5 | 139 | 72 | None | -13 | 54 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00044a001 | |||
| 5202 | 139 | 72 | None | -13 | 54 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00044a001 | |||
| CHEMBL39 | 139 | 72 | None | -13 | 54 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00044a001 | |||
| DB08839 | 139 | 72 | None | -13 | 54 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00044a001 | |||
| 5 | 139 | 72 | None | -13 | 54 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00399a031 | |||
| 5202 | 139 | 72 | None | -13 | 54 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00399a031 | |||
| CHEMBL39 | 139 | 72 | None | -13 | 54 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00399a031 | |||
| DB08839 | 139 | 72 | None | -13 | 54 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00399a031 | |||
| 2543 | 3707 | 68 | None | -3 | 32 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00044a001 | |||
| 5358 | 3707 | 68 | None | -3 | 32 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00044a001 | |||
| 54 | 3707 | 68 | None | -3 | 32 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00044a001 | |||
| CHEMBL128 | 3707 | 68 | None | -3 | 32 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00044a001 | |||
| DB00669 | 3707 | 68 | None | -3 | 32 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00044a001 | |||
| 10775128 | 188731 | 3 | None | -2 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 216 | 4 | 1 | 1 | 2.8 | CCc1ccc2[nH]cc(CCN(C)C)c2c1 | 10.1021/jm950498t | |||
| CHEMBL50492 | 188731 | 3 | None | -2 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 216 | 4 | 1 | 1 | 2.8 | CCc1ccc2[nH]cc(CCN(C)C)c2c1 | 10.1021/jm950498t | |||
| 44342767 | 114959 | 0 | None | -8 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 430 | 4 | 2 | 2 | 5.5 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(/C(S)=N/c4ccccc4)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
| CHEMBL334259 | 114959 | 0 | None | -8 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 430 | 4 | 2 | 2 | 5.5 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(/C(S)=N/c4ccccc4)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
| 11016395 | 111553 | 0 | None | -1 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 486 | 6 | 1 | 5 | 4.4 | Cn1nccc1-c1ccc2c(c1)c(C1CCN(CCN3CCNC3=O)CC1)cn2-c1ccc(F)cc1 | 10.1021/jm020938y | |||
| CHEMBL328048 | 111553 | 0 | None | -1 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 486 | 6 | 1 | 5 | 4.4 | Cn1nccc1-c1ccc2c(c1)c(C1CCN(CCN3CCNC3=O)CC1)cn2-c1ccc(F)cc1 | 10.1021/jm020938y | |||
| 2303 | 3187 | 68 | None | -57 | 26 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm00384a001 | |||
| 4946 | 3187 | 68 | None | -57 | 26 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm00384a001 | |||
| 564 | 3187 | 68 | None | -57 | 26 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm00384a001 | |||
| 63 | 3187 | 68 | None | -57 | 26 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm00384a001 | |||
| 91536 | 3187 | 68 | None | -57 | 26 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm00384a001 | |||
| CHEMBL27 | 3187 | 68 | None | -57 | 26 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm00384a001 | |||
| CHEMBL452861 | 3187 | 68 | None | -57 | 26 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm00384a001 | |||
| DB00571 | 3187 | 68 | None | -57 | 26 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm00384a001 | |||
| 59636757 | 125707 | 0 | None | - | 1 | Chinese hamster | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 448 | 7 | 1 | 6 | 3.3 | O=C(NCC1CCOCC1)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| CHEMBL3647289 | 125707 | 0 | None | - | 1 | Chinese hamster | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 448 | 7 | 1 | 6 | 3.3 | O=C(NCC1CCOCC1)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| 2303 | 3187 | 68 | None | -57 | 26 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm00124a021 | |||
| 4946 | 3187 | 68 | None | -57 | 26 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm00124a021 | |||
| 564 | 3187 | 68 | None | -57 | 26 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm00124a021 | |||
| 63 | 3187 | 68 | None | -57 | 26 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm00124a021 | |||
| 91536 | 3187 | 68 | None | -57 | 26 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm00124a021 | |||
| CHEMBL27 | 3187 | 68 | None | -57 | 26 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm00124a021 | |||
| CHEMBL452861 | 3187 | 68 | None | -57 | 26 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm00124a021 | |||
| DB00571 | 3187 | 68 | None | -57 | 26 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1021/jm00124a021 | |||
| 44402878 | 71407 | 0 | None | 2 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 506 | 4 | 1 | 5 | 5.6 | COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(C(=O)c1ccc(-c3cccc(C)n3)c3ccccc13)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| CHEMBL195897 | 71407 | 0 | None | 2 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 506 | 4 | 1 | 5 | 5.6 | COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(C(=O)c1ccc(-c3cccc(C)n3)c3ccccc13)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| 44588721 | 184346 | 0 | None | -6 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 419 | 7 | 1 | 6 | 3.3 | Cc1ccc2c(OCCN3CC(COc4ccc5c(c4)NC(=O)CO5)C3)cccc2n1 | 10.1016/j.bmcl.2008.08.110 | |||
| CHEMBL484387 | 184346 | 0 | None | -6 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 419 | 7 | 1 | 6 | 3.3 | Cc1ccc2c(OCCN3CC(COc4ccc5c(c4)NC(=O)CO5)C3)cccc2n1 | 10.1016/j.bmcl.2008.08.110 | |||
| 10024936 | 184963 | 0 | None | -19 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 416 | 5 | 1 | 5 | 3.6 | Cc1ccc2c(N3CCN(CCCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.110 | |||
| CHEMBL485395 | 184963 | 0 | None | -19 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 416 | 5 | 1 | 5 | 3.6 | Cc1ccc2c(N3CCN(CCCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.110 | |||
| 24865542 | 188127 | 0 | None | -39 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 445 | 8 | 1 | 4 | 5.5 | Cc1ccc2c(OCCN3CCC(Cc4cccc(NC(=O)C(C)C)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
| CHEMBL498355 | 188127 | 0 | None | -39 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 445 | 8 | 1 | 4 | 5.5 | Cc1ccc2c(OCCN3CCC(Cc4cccc(NC(=O)C(C)C)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
| 10194820 | 188864 | 0 | None | -158 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 432 | 7 | 0 | 5 | 3.7 | CC(=O)N(C)c1cccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm8001444 | |||
| CHEMBL506942 | 188864 | 0 | None | -158 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 432 | 7 | 0 | 5 | 3.7 | CC(=O)N(C)c1cccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1 | 10.1021/jm8001444 | |||
| 9891618 | 107124 | 0 | None | -501 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 486 | 4 | 1 | 6 | 5.0 | Cc1c(S(=O)(=O)Nc2ccc3nccc(N4CCN(C)CC4)c3c2)sc2ccc(Cl)cc12 | 10.1016/s0960-894x(01)00558-3 | |||
| CHEMBL316081 | 107124 | 0 | None | -501 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 486 | 4 | 1 | 6 | 5.0 | Cc1c(S(=O)(=O)Nc2ccc3nccc(N4CCN(C)CC4)c3c2)sc2ccc(Cl)cc12 | 10.1016/s0960-894x(01)00558-3 | |||
| 9891002 | 107408 | 0 | None | -501 | 7 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 472 | 4 | 2 | 6 | 4.6 | Cc1sc2ccc(Cl)cc2c1S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1 | 10.1016/s0960-894x(01)00558-3 | |||
| CHEMBL318018 | 107408 | 0 | None | -501 | 7 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 472 | 4 | 2 | 6 | 4.6 | Cc1sc2ccc(Cl)cc2c1S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1 | 10.1016/s0960-894x(01)00558-3 | |||
| 24865539 | 187645 | 0 | None | -39 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 391 | 7 | 0 | 5 | 3.7 | COc1ccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)cc1 | 10.1021/jm8001444 | |||
| CHEMBL494991 | 187645 | 0 | None | -39 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 391 | 7 | 0 | 5 | 3.7 | COc1ccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)cc1 | 10.1021/jm8001444 | |||
| 1534 | 103040 | 53 | None | -5 | 12 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 174 | 2 | 2 | 1 | 2.1 | CC(N)Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2013.03.066 | |||
| 9287 | 103040 | 53 | None | -5 | 12 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 174 | 2 | 2 | 1 | 2.1 | CC(N)Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2013.03.066 | |||
| CHEMBL30713 | 103040 | 53 | None | -5 | 12 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 174 | 2 | 2 | 1 | 2.1 | CC(N)Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2013.03.066 | |||
| 14975310 | 77233 | 0 | None | -66 | 2 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 245 | 3 | 0 | 2 | 3.1 | CCCN1CC[C@H]2c3c(cccc3OC)C[C@@H]2C1 | 10.1021/jm00027a013 | |||
| CHEMBL2079544 | 77233 | 0 | None | -66 | 2 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 245 | 3 | 0 | 2 | 3.1 | CCCN1CC[C@H]2c3c(cccc3OC)C[C@@H]2C1 | 10.1021/jm00027a013 | |||
| 9957068 | 51944 | 0 | None | -1000 | 5 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 486 | 8 | 1 | 5 | 4.3 | CS(=O)(=O)Oc1ccc2c(c1)CN(CC[C@H]1CC[C@H](NC(=O)/C=C/c3ccc(F)cc3)CC1)C2 | 10.1016/s0960-894x(01)00037-3 | |||
| CHEMBL158627 | 51944 | 0 | None | -1000 | 5 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 486 | 8 | 1 | 5 | 4.3 | CS(=O)(=O)Oc1ccc2c(c1)CN(CC[C@H]1CC[C@H](NC(=O)/C=C/c3ccc(F)cc3)CC1)C2 | 10.1016/s0960-894x(01)00037-3 | |||
| 10164215 | 142009 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 504 | 6 | 1 | 8 | 3.2 | COc1cc(N2CCN(C)CC2)c2nc(C(=O)Nc3ccc(N4CCOCC4)cc3)cc(N(C)C)c2c1 | 10.1016/j.bmc.2006.10.037 | |||
| CHEMBL387545 | 142009 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 504 | 6 | 1 | 8 | 3.2 | COc1cc(N2CCN(C)CC2)c2nc(C(=O)Nc3ccc(N4CCOCC4)cc3)cc(N(C)C)c2c1 | 10.1016/j.bmc.2006.10.037 | |||
| 44339072 | 111378 | 1 | None | 1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 274 | 5 | 1 | 3 | 2.8 | CC(C)C(=O)Oc1ccc2[nH]cc(CCN(C)C)c2c1 | 10.1021/jm950498t | |||
| CHEMBL327103 | 111378 | 1 | None | 1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 274 | 5 | 1 | 3 | 2.8 | CC(C)C(=O)Oc1ccc2[nH]cc(CCN(C)C)c2c1 | 10.1021/jm950498t | |||
| 4376990 | 193009 | 5 | None | -20 | 11 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 372 | 4 | 2 | 4 | 4.1 | COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC | 10.1021/acsmedchemlett.1c00694 | |||
| CHEMBL5207529 | 193009 | 5 | None | -20 | 11 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 372 | 4 | 2 | 4 | 4.1 | COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC | 10.1021/acsmedchemlett.1c00694 | |||
| CHEMBL5222754 | 193009 | 5 | None | -20 | 11 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 372 | 4 | 2 | 4 | 4.1 | COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC | 10.1021/acsmedchemlett.1c00694 | |||
| 1574 | 81 | 60 | None | -24 | 21 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | 10.1021/jm00164a046 | |||
| 218 | 81 | 60 | None | -24 | 21 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | 10.1021/jm00164a046 | |||
| CHEMBL266591 | 81 | 60 | None | -24 | 21 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | 10.1021/jm00164a046 | |||
| 44581972 | 175600 | 0 | None | -17 | 10 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 499 | 6 | 2 | 6 | 4.3 | O=C(Nc1cccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)c1)c1ccc(-c2ccccc2)cc1 | 10.1021/jm800962k | |||
| CHEMBL458001 | 175600 | 0 | None | -17 | 10 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 499 | 6 | 2 | 6 | 4.3 | O=C(Nc1cccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)c1)c1ccc(-c2ccccc2)cc1 | 10.1021/jm800962k | |||
| 10663236 | 5461 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 316 | 11 | 2 | 2 | 5.2 | CCCCCCCCCOc1ccc2[nH]cc(CC(C)N)c2c1 | 10.1021/jm950498t | |||
| CHEMBL107487 | 5461 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 316 | 11 | 2 | 2 | 5.2 | CCCCCCCCCOc1ccc2[nH]cc(CC(C)N)c2c1 | 10.1021/jm950498t | |||
| 3025067 | 99382 | 64 | None | -2 | 15 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 220 | 1 | 1 | 4 | 0.9 | c1cc2c(c(N3CCNCC3)c1)OCCO2 | 10.1021/jm00020a020 | |||
| 65853 | 99382 | 64 | None | -2 | 15 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 220 | 1 | 1 | 4 | 0.9 | c1cc2c(c(N3CCNCC3)c1)OCCO2 | 10.1021/jm00020a020 | |||
| CHEMBL282614 | 99382 | 64 | None | -2 | 15 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 220 | 1 | 1 | 4 | 0.9 | c1cc2c(c(N3CCNCC3)c1)OCCO2 | 10.1021/jm00020a020 | |||
| 10248619 | 115130 | 0 | None | -138 | 2 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 370 | 3 | 0 | 4 | 3.6 | Clc1cccc2c1CC2CN1CCN(c2cccc3c2OCCO3)CC1 | 10.1021/jm00020a020 | |||
| CHEMBL334381 | 115130 | 0 | None | -138 | 2 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 370 | 3 | 0 | 4 | 3.6 | Clc1cccc2c1CC2CN1CCN(c2cccc3c2OCCO3)CC1 | 10.1021/jm00020a020 | |||
| 9997421 | 204137 | 0 | None | -22 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 341 | 7 | 2 | 3 | 2.8 | CCCN(CCC)C1CCc2ccc3[nH]cc(C(=O)C(N)=O)c3c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL70431 | 204137 | 0 | None | -22 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 341 | 7 | 2 | 3 | 2.8 | CCCN(CCC)C1CCc2ccc3[nH]cc(C(=O)C(N)=O)c3c2C1 | 10.1021/jm00012a021 | |||
| 1220 | 187 | 55 | None | -208 | 44 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1016/s0960-894x(98)00222-4 | |||
| 31 | 187 | 55 | None | -208 | 44 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1016/s0960-894x(98)00222-4 | |||
| 7 | 187 | 55 | None | -208 | 44 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1016/s0960-894x(98)00222-4 | |||
| CHEMBL56 | 187 | 55 | None | -208 | 44 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1016/s0960-894x(98)00222-4 | |||
| 1534 | 103040 | 53 | None | -5 | 12 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 174 | 2 | 2 | 1 | 2.1 | CC(N)Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2013.03.066 | |||
| 9287 | 103040 | 53 | None | -5 | 12 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 174 | 2 | 2 | 1 | 2.1 | CC(N)Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2013.03.066 | |||
| CHEMBL30713 | 103040 | 53 | None | -5 | 12 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 174 | 2 | 2 | 1 | 2.1 | CC(N)Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2013.03.066 | |||
| 2435 | 3590 | 83 | None | -128 | 48 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1021/jm020938y | |||
| 60149 | 3590 | 83 | None | -128 | 48 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1021/jm020938y | |||
| 98 | 3590 | 83 | None | -128 | 48 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1021/jm020938y | |||
| CHEMBL12713 | 3590 | 83 | None | -128 | 48 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1021/jm020938y | |||
| DB06144 | 3590 | 83 | None | -128 | 48 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1021/jm020938y | |||
| 10021450 | 102702 | 0 | None | -1412 | 5 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 360 | 7 | 1 | 2 | 4.8 | CCCN(CCc1ccccc1)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL304767 | 102702 | 0 | None | -1412 | 5 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 360 | 7 | 1 | 2 | 4.8 | CCCN(CCc1ccccc1)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| 10973768 | 107560 | 0 | None | -1445 | 9 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 563 | 6 | 1 | 8 | 4.4 | Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCn4c(=O)[nH]c5ccccc5c4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | |||
| CHEMBL318901 | 107560 | 0 | None | -1445 | 9 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 563 | 6 | 1 | 8 | 4.4 | Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCn4c(=O)[nH]c5ccccc5c4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | |||
| 9976035 | 21050 | 0 | None | -489 | 2 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 364 | 4 | 0 | 4 | 3.7 | c1ccc2c(c1)CC2CCN1CCN(c2cccc3c2OCCCO3)CC1 | 10.1021/jm00020a020 | |||
| CHEMBL131184 | 21050 | 0 | None | -489 | 2 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 364 | 4 | 0 | 4 | 3.7 | c1ccc2c(c1)CC2CCN1CCN(c2cccc3c2OCCCO3)CC1 | 10.1021/jm00020a020 | |||
| 14519861 | 59164 | 0 | None | -25 | 2 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 313 | 11 | 0 | 2 | 5.5 | CCCCN(CCCC)CCCOc1cccc2ccccc12 | 10.1021/jm00124a021 | |||
| CHEMBL169956 | 59164 | 0 | None | -25 | 2 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 313 | 11 | 0 | 2 | 5.5 | CCCCN(CCCC)CCCOc1cccc2ccccc12 | 10.1021/jm00124a021 | |||
| 44304338 | 100580 | 0 | None | -5 | 2 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 275 | 6 | 0 | 2 | 4.0 | CCCN(CCC)C1CCc2c(C)ccc(OC)c2C1 | 10.1016/S0960-894X(01)81009-X | |||
| CHEMBL291620 | 100580 | 0 | None | -5 | 2 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 275 | 6 | 0 | 2 | 4.0 | CCCN(CCC)C1CCc2c(C)ccc(OC)c2C1 | 10.1016/S0960-894X(01)81009-X | |||
| 3228 | 3146 | 23 | None | -6456 | 7 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 409 | 6 | 1 | 5 | 2.9 | CNC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CCN(CC1)c1ccc(cc1)OC | 10.1016/j.ejmech.2020.113073 | |||
| 9909448 | 3146 | 23 | None | -6456 | 7 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 409 | 6 | 1 | 5 | 2.9 | CNC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CCN(CC1)c1ccc(cc1)OC | 10.1016/j.ejmech.2020.113073 | |||
| CHEMBL71838 | 3146 | 23 | None | -6456 | 7 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 409 | 6 | 1 | 5 | 2.9 | CNC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CCN(CC1)c1ccc(cc1)OC | 10.1016/j.ejmech.2020.113073 | |||
| 3228 | 3146 | 23 | None | -6456 | 7 | Western lowland gorilla | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 409 | 6 | 1 | 5 | 2.9 | CNC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CCN(CC1)c1ccc(cc1)OC | 10.1021/jm980137o | |||
| 9909448 | 3146 | 23 | None | -6456 | 7 | Western lowland gorilla | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 409 | 6 | 1 | 5 | 2.9 | CNC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CCN(CC1)c1ccc(cc1)OC | 10.1021/jm980137o | |||
| CHEMBL71838 | 3146 | 23 | None | -6456 | 7 | Western lowland gorilla | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 409 | 6 | 1 | 5 | 2.9 | CNC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CCN(CC1)c1ccc(cc1)OC | 10.1021/jm980137o | |||
| 10774567 | 103822 | 0 | None | -5 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 204 | 2 | 2 | 3 | 1.6 | Cc1ccc(O)c(C)c1CC1=NCCN1 | 10.1021/jm970513p | |||
| CHEMBL309162 | 103822 | 0 | None | -5 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 204 | 2 | 2 | 3 | 1.6 | Cc1ccc(O)c(C)c1CC1=NCCN1 | 10.1021/jm970513p | |||
| 44376395 | 52594 | 0 | None | -9 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 460 | 7 | 2 | 4 | 4.8 | COc1ccc(C(=S)NN2CC=C(c3ccc4[nH]cc(CCN5CCCC5)c4c3)CC2)cc1 | 10.1016/j.bmcl.2003.11.023 | |||
| CHEMBL159278 | 52594 | 0 | None | -9 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 460 | 7 | 2 | 4 | 4.8 | COc1ccc(C(=S)NN2CC=C(c3ccc4[nH]cc(CCN5CCCC5)c4c3)CC2)cc1 | 10.1016/j.bmcl.2003.11.023 | |||
| CHEMBL5094234 | 215573 | 0 | None | -275 | 8 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | None | None | None | CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
| CHEMBL5096019 | 215573 | 0 | None | -275 | 8 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | None | None | None | CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
| 23288790 | 203964 | 0 | None | -691 | 6 | Western lowland gorilla | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 395 | 6 | 1 | 5 | 2.6 | COc1ccc(N2CCN(CCC3OCCc4cc(C(N)=O)ccc43)CC2)cc1 | 10.1021/jm980137o | |||
| CHEMBL69385 | 203964 | 0 | None | -691 | 6 | Western lowland gorilla | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 395 | 6 | 1 | 5 | 2.6 | COc1ccc(N2CCN(CCC3OCCc4cc(C(N)=O)ccc43)CC2)cc1 | 10.1021/jm980137o | |||
| 9972838 | 204303 | 0 | None | -41 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 312 | 6 | 1 | 2 | 4.4 | CCCN(CCC)C1CCc2ccc3[nH]cc(C(C)=O)c3c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL71395 | 204303 | 0 | None | -41 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 312 | 6 | 1 | 2 | 4.4 | CCCN(CCC)C1CCc2ccc3[nH]cc(C(C)=O)c3c2C1 | 10.1021/jm00012a021 | |||
| 44581974 | 175704 | 0 | None | -11 | 9 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 513 | 6 | 2 | 6 | 4.6 | Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2ccccc2)cc1 | 10.1021/jm800962k | |||
| CHEMBL458220 | 175704 | 0 | None | -11 | 9 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 513 | 6 | 2 | 6 | 4.6 | Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2ccccc2)cc1 | 10.1021/jm800962k | |||
| 2585 | 803 | 103 | None | -100 | 21 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | nan | |||
| 522 | 803 | 103 | None | -100 | 21 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | nan | |||
| 551 | 803 | 103 | None | -100 | 21 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | nan | |||
| CHEMBL723 | 803 | 103 | None | -100 | 21 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | nan | |||
| DB01136 | 803 | 103 | None | -100 | 21 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | nan | |||
| 160463 | 69188 | 31 | None | -3 | 3 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2cc(O)ccc12 | 10.1021/jm00384a001 | |||
| CHEMBL19264 | 69188 | 31 | None | -3 | 3 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2cc(O)ccc12 | 10.1021/jm00384a001 | |||
| 44338900 | 109644 | 1 | None | -3 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 260 | 5 | 1 | 3 | 2.6 | CCC(=O)Oc1ccc2[nH]cc(CCN(C)C)c2c1 | 10.1021/jm950498t | |||
| CHEMBL322349 | 109644 | 1 | None | -3 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 260 | 5 | 1 | 3 | 2.6 | CCC(=O)Oc1ccc2[nH]cc(CCN(C)C)c2c1 | 10.1021/jm950498t | |||
| 10915350 | 163406 | 0 | None | -53 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 359 | 3 | 2 | 4 | 3.5 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccc(C#N)c4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL419547 | 163406 | 0 | None | -53 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 359 | 3 | 2 | 4 | 3.5 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccc(C#N)c4)nc23)CC1 | 10.1021/jm030020m | |||
| 10500422 | 78475 | 0 | None | 15 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 387 | 7 | 1 | 4 | 4.6 | COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1/C=C\CN(C)C | 10.1021/jm9702948 | |||
| CHEMBL2111779 | 78475 | 0 | None | 15 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 387 | 7 | 1 | 4 | 4.6 | COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1/C=C\CN(C)C | 10.1021/jm9702948 | |||
| 130 | 3500 | 47 | None | -1 | 13 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm970457s | |||
| 3378093 | 3500 | 47 | None | -1 | 13 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm970457s | |||
| CHEMBL281350 | 3500 | 47 | None | -1 | 13 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.1021/jm970457s | |||
| 11796257 | 98680 | 1 | None | 1 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 417 | 4 | 1 | 4 | 3.8 | COc1ccc(NC(=O)c2ccc(Br)c(C)c2)cc1N1CCN(C)CC1 | 10.1021/jm970457s | |||
| CHEMBL277467 | 98680 | 1 | None | 1 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 417 | 4 | 1 | 4 | 3.8 | COc1ccc(NC(=O)c2ccc(Br)c(C)c2)cc1N1CCN(C)CC1 | 10.1021/jm970457s | |||
| 10114480 | 93596 | 0 | None | -3 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 445 | 6 | 0 | 5 | 4.2 | Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2007.06.078 | |||
| CHEMBL246597 | 93596 | 0 | None | -3 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 445 | 6 | 0 | 5 | 4.2 | Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2007.06.078 | |||
| 10195275 | 175692 | 0 | None | -12 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 458 | 7 | 0 | 5 | 4.6 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCN(C)CC5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| CHEMBL458199 | 175692 | 0 | None | -12 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 458 | 7 | 0 | 5 | 4.6 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCN(C)CC5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| 44581603 | 176058 | 0 | None | -5 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 443 | 7 | 1 | 4 | 5.3 | Cc1ccc2c(OCCN3CCC(Cc4cccc(C5CCNCC5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| CHEMBL459067 | 176058 | 0 | None | -5 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 443 | 7 | 1 | 4 | 5.3 | Cc1ccc2c(OCCN3CCC(Cc4cccc(C5CCNCC5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| 10127673 | 187832 | 0 | None | -6 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 460 | 9 | 1 | 5 | 4.4 | Cc1ccc2c(OCCN3CCC(Cc4cccc(NC(=O)CN(C)C)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| CHEMBL496098 | 187832 | 0 | None | -6 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 460 | 9 | 1 | 5 | 4.4 | Cc1ccc2c(OCCN3CCC(Cc4cccc(NC(=O)CN(C)C)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| 10048343 | 184219 | 0 | None | -10 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 430 | 6 | 1 | 5 | 4.0 | Cc1ccc2c(N3CCN(CCCCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.110 | |||
| CHEMBL483365 | 184219 | 0 | None | -10 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 430 | 6 | 1 | 5 | 4.0 | Cc1ccc2c(N3CCN(CCCCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.110 | |||
| 10127673 | 187832 | 0 | None | -6 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 460 | 9 | 1 | 5 | 4.4 | Cc1ccc2c(OCCN3CCC(Cc4cccc(NC(=O)CN(C)C)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
| CHEMBL496098 | 187832 | 0 | None | -6 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 460 | 9 | 1 | 5 | 4.4 | Cc1ccc2c(OCCN3CCC(Cc4cccc(NC(=O)CN(C)C)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
| 10481003 | 102953 | 0 | None | -1 | 3 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(C(=O)Nc2ccc(-c3ccc(-c4noc(C)n4)cc3C)cc2)cc1N1CCN(C)CC1 | 10.1021/jm00041a001 | |||
| CHEMBL306384 | 102953 | 0 | None | -1 | 3 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(C(=O)Nc2ccc(-c3ccc(-c4noc(C)n4)cc3C)cc2)cc1N1CCN(C)CC1 | 10.1021/jm00041a001 | |||
| 9891594 | 104881 | 0 | None | -1 | 3 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 486 | 6 | 1 | 5 | 4.4 | COc1ccc(NC(=O)c2ccc(-c3ccc(C(=O)N(C)C)cc3C)cc2)cc1N1CCN(C)CC1 | 10.1021/jm00041a001 | |||
| CHEMBL311150 | 104881 | 0 | None | -1 | 3 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 486 | 6 | 1 | 5 | 4.4 | COc1ccc(NC(=O)c2ccc(-c3ccc(C(=O)N(C)C)cc3C)cc2)cc1N1CCN(C)CC1 | 10.1021/jm00041a001 | |||
| 10076876 | 101712 | 0 | None | -1 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 576 | 19 | 0 | 4 | 8.7 | CCCN(CCC)C1CCc2cccc(OCCCCCCOc3cccc4c3CC(N(CCC)CCC)CC4)c2C1 | 10.1016/s0960-894x(98)00222-4 | |||
| CHEMBL29951 | 101712 | 0 | None | -1 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 576 | 19 | 0 | 4 | 8.7 | CCCN(CCC)C1CCc2cccc(OCCCCCCOc3cccc4c3CC(N(CCC)CCC)CC4)c2C1 | 10.1016/s0960-894x(98)00222-4 | |||
| 2543 | 3707 | 68 | None | -2 | 32 | Western lowland gorilla | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm980137o | |||
| 5358 | 3707 | 68 | None | -2 | 32 | Western lowland gorilla | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm980137o | |||
| 54 | 3707 | 68 | None | -2 | 32 | Western lowland gorilla | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm980137o | |||
| CHEMBL128 | 3707 | 68 | None | -2 | 32 | Western lowland gorilla | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm980137o | |||
| DB00669 | 3707 | 68 | None | -2 | 32 | Western lowland gorilla | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm980137o | |||
| 107 | 141 | 121 | None | -30 | 30 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10.1021/jm00402a026 | |||
| 1833 | 141 | 121 | None | -30 | 30 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10.1021/jm00402a026 | |||
| CHEMBL8165 | 141 | 121 | None | -30 | 30 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10.1021/jm00402a026 | |||
| 11092142 | 208168 | 0 | None | 1 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 487 | 6 | 1 | 6 | 3.8 | Cn1ncnc1-c1ccc2c(c1)c(C1CCN(CCN3CCNC3=O)CC1)cn2-c1ccc(F)cc1 | 10.1021/jm020938y | |||
| CHEMBL98299 | 208168 | 0 | None | 1 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 487 | 6 | 1 | 6 | 3.8 | Cn1ncnc1-c1ccc2c(c1)c(C1CCN(CCN3CCNC3=O)CC1)cn2-c1ccc(F)cc1 | 10.1021/jm020938y | |||
| 9817810 | 17372 | 1 | None | -2 | 8 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 300 | 4 | 1 | 4 | 2.4 | NCCc1cccc2c1ccn2S(=O)(=O)c1ccccc1 | 10.1021/jm010943m | |||
| CHEMBL125745 | 17372 | 1 | None | -2 | 8 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 300 | 4 | 1 | 4 | 2.4 | NCCc1cccc2c1ccn2S(=O)(=O)c1ccccc1 | 10.1021/jm010943m | |||
| 59636777 | 125689 | 0 | None | - | 1 | Chinese hamster | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 390 | 6 | 1 | 5 | 3.1 | O=C(NC1CC1)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| CHEMBL3647271 | 125689 | 0 | None | - | 1 | Chinese hamster | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 390 | 6 | 1 | 5 | 3.1 | O=C(NC1CC1)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| 5 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(98)00222-4 | |||
| 5202 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(98)00222-4 | |||
| CHEMBL39 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(98)00222-4 | |||
| DB08839 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(98)00222-4 | |||
| 10944016 | 207899 | 20 | None | 1 | 3 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 220 | 3 | 1 | 3 | 1.9 | CC(C)Oc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
| CHEMBL9669 | 207899 | 20 | None | 1 | 3 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 220 | 3 | 1 | 3 | 1.9 | CC(C)Oc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
| 4233538 | 198048 | 4 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 346 | 5 | 1 | 6 | 1.2 | C1=C(CN2CCOCC2)COc2c1cccc2OCC1CNCCO1 | 10.1021/jm970806i | |||
| CHEMBL1201939 | 198048 | 4 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 346 | 5 | 1 | 6 | 1.2 | C1=C(CN2CCOCC2)COc2c1cccc2OCC1CNCCO1 | 10.1021/jm970806i | |||
| CHEMBL57406 | 198048 | 4 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 346 | 5 | 1 | 6 | 1.2 | C1=C(CN2CCOCC2)COc2c1cccc2OCC1CNCCO1 | 10.1021/jm970806i | |||
| 44560995 | 179153 | 0 | None | -109 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 498 | 5 | 2 | 5 | 4.7 | FC(F)(F)c1nc2c(N3CCN(CCOc4cccc5nc(C(F)(F)F)[nH]c45)CC3)cccc2[nH]1 | 10.1016/j.bmc.2008.05.024 | |||
| CHEMBL472117 | 179153 | 0 | None | -109 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 498 | 5 | 2 | 5 | 4.7 | FC(F)(F)c1nc2c(N3CCN(CCOc4cccc5nc(C(F)(F)F)[nH]c45)CC3)cccc2[nH]1 | 10.1016/j.bmc.2008.05.024 | |||
| 10198320 | 204610 | 1 | None | -46 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 218 | 2 | 2 | 1 | 3.1 | Cc1cc(C(C)(C)C)cc(C)c1CC(=N)N | 10.1021/jm970513p | |||
| CHEMBL73281 | 204610 | 1 | None | -46 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 218 | 2 | 2 | 1 | 3.1 | Cc1cc(C(C)(C)C)cc(C)c1CC(=N)N | 10.1021/jm970513p | |||
| 11024618 | 108553 | 0 | None | -89 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 353 | 3 | 2 | 4 | 3.2 | CN1CCC(c2c[nH]c3cnc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL320198 | 108553 | 0 | None | -89 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 353 | 3 | 2 | 4 | 3.2 | CN1CCC(c2c[nH]c3cnc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| 107992 | 2553 | 49 | None | -12 | 10 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 198 | 1 | 1 | 4 | 0.5 | Clc1cncc(n1)N1CCNCC1 | 10.1021/jm00145a017 | |||
| 165 | 2553 | 49 | None | -12 | 10 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 198 | 1 | 1 | 4 | 0.5 | Clc1cncc(n1)N1CCNCC1 | 10.1021/jm00145a017 | |||
| CHEMBL269521 | 2553 | 49 | None | -12 | 10 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 198 | 1 | 1 | 4 | 0.5 | Clc1cncc(n1)N1CCNCC1 | 10.1021/jm00145a017 | |||
| DB12111 | 2553 | 49 | None | -12 | 10 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 198 | 1 | 1 | 4 | 0.5 | Clc1cncc(n1)N1CCNCC1 | 10.1021/jm00145a017 | |||
| 182595 | 19937 | 14 | None | -1000 | 4 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 350 | 4 | 0 | 4 | 3.3 | c1ccc2c(c1)CC2CCN1CCN(c2cccc3c2OCCO3)CC1 | 10.1021/jm00020a020 | |||
| CHEMBL130276 | 19937 | 14 | None | -1000 | 4 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 350 | 4 | 0 | 4 | 3.3 | c1ccc2c(c1)CC2CCN1CCN(c2cccc3c2OCCO3)CC1 | 10.1021/jm00020a020 | |||
| 25067564 | 201300 | 0 | None | -1348 | 6 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 392 | 3 | 2 | 5 | 3.1 | N[C@@H]1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1 | 10.1021/jm901674f | |||
| CHEMBL604102 | 201300 | 0 | None | -1348 | 6 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 392 | 3 | 2 | 5 | 3.1 | N[C@@H]1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1 | 10.1021/jm901674f | |||
| 9860595 | 10085 | 2 | None | -77 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 283 | 4 | 1 | 2 | 3.0 | CN(C)CCc1c[nH]c2ccc(C3=CCN(C)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
| CHEMBL115415 | 10085 | 2 | None | -77 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 283 | 4 | 1 | 2 | 3.0 | CN(C)CCc1c[nH]c2ccc(C3=CCN(C)CC3)cc12 | 10.1016/s0960-894x(03)00779-0 | |||
| 9860595 | 10085 | 2 | None | -77 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 283 | 4 | 1 | 2 | 3.0 | CN(C)CCc1c[nH]c2ccc(C3=CCN(C)CC3)cc12 | 10.1016/j.bmcl.2003.11.023 | |||
| CHEMBL115415 | 10085 | 2 | None | -77 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 283 | 4 | 1 | 2 | 3.0 | CN(C)CCc1c[nH]c2ccc(C3=CCN(C)CC3)cc12 | 10.1016/j.bmcl.2003.11.023 | |||
| 11822996 | 5059 | 0 | None | -32 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 308 | 3 | 2 | 4 | 1.7 | CN1CCC(c2c[nH]c3ccc(NS(C)(=O)=O)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL105327 | 5059 | 0 | None | -32 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 308 | 3 | 2 | 4 | 1.7 | CN1CCC(c2c[nH]c3ccc(NS(C)(=O)=O)nc23)CC1 | 10.1021/jm030020m | |||
| 14519859 | 130209 | 2 | None | -13 | 2 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 285 | 9 | 0 | 2 | 4.7 | CCCN(CCC)CCCOc1cccc2ccccc12 | 10.1021/jm00124a021 | |||
| CHEMBL367935 | 130209 | 2 | None | -13 | 2 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 285 | 9 | 0 | 2 | 4.7 | CCCN(CCC)CCCOc1cccc2ccccc12 | 10.1021/jm00124a021 | |||
| 3823 | 50221 | 42 | None | -38 | 10 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 530 | 7 | 0 | 7 | 4.2 | CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | nan | |||
| 76973198 | 50221 | 42 | None | -38 | 10 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 530 | 7 | 0 | 7 | 4.2 | CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | nan | |||
| CHEMBL157101 | 50221 | 42 | None | -38 | 10 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 530 | 7 | 0 | 7 | 4.2 | CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | nan | |||
| 10091074 | 116666 | 0 | None | -776 | 2 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 378 | 5 | 0 | 4 | 4.1 | c1ccc2c(c1)CC2CCCN1CCN(c2cccc3c2OCCCO3)CC1 | 10.1021/jm00020a020 | |||
| CHEMBL337078 | 116666 | 0 | None | -776 | 2 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 378 | 5 | 0 | 4 | 4.1 | c1ccc2c(c1)CC2CCCN1CCN(c2cccc3c2OCCCO3)CC1 | 10.1021/jm00020a020 | |||
| 10065239 | 204289 | 0 | None | -21 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 330 | 6 | 0 | 3 | 4.1 | CCCN(CCC)C1CCc2cc(F)c3c(c(C=O)cn3C)c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL71319 | 204289 | 0 | None | -21 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 330 | 6 | 0 | 3 | 4.1 | CCCN(CCC)C1CCc2cc(F)c3c(c(C=O)cn3C)c2C1 | 10.1021/jm00012a021 | |||
| 44376722 | 55494 | 0 | None | -7 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 428 | 6 | 2 | 3 | 4.5 | Cc1ccc(C(=O)NN2CC=C(c3ccc4[nH]cc(CCN5CCCC5)c4c3)CC2)cc1 | 10.1016/j.bmcl.2003.11.023 | |||
| CHEMBL162012 | 55494 | 0 | None | -7 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 428 | 6 | 2 | 3 | 4.5 | Cc1ccc(C(=O)NN2CC=C(c3ccc4[nH]cc(CCN5CCCC5)c4c3)CC2)cc1 | 10.1016/j.bmcl.2003.11.023 | |||
| 44339071 | 8435 | 1 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 288 | 4 | 1 | 3 | 3.2 | CN(C)CCc1c[nH]c2ccc(OC(=O)C(C)(C)C)cc12 | 10.1021/jm950498t | |||
| CHEMBL109360 | 8435 | 1 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 288 | 4 | 1 | 3 | 3.2 | CN(C)CCc1c[nH]c2ccc(OC(=O)C(C)(C)C)cc12 | 10.1021/jm950498t | |||
| 59636760 | 125697 | 0 | None | - | 1 | Chinese hamster | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 455 | 7 | 0 | 6 | 3.9 | CN(Cc1cccnc1)C(=O)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| CHEMBL3647279 | 125697 | 0 | None | - | 1 | Chinese hamster | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 455 | 7 | 0 | 6 | 3.9 | CN(Cc1cccnc1)C(=O)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| 10150796 | 67608 | 0 | None | -251 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 401 | 6 | 1 | 5 | 3.6 | Cc1ccc2c(OCCN3CCN(Cc4cccc5[nH]cnc45)CC3)cccc2n1 | 10.1021/jm049039v | |||
| CHEMBL190298 | 67608 | 0 | None | -251 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 401 | 6 | 1 | 5 | 3.6 | Cc1ccc2c(OCCN3CCN(Cc4cccc5[nH]cnc45)CC3)cccc2n1 | 10.1021/jm049039v | |||
| 44443098 | 93929 | 0 | None | -15 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 522 | 8 | 0 | 6 | 4.7 | Cc1ccc2c(OCCN3CCN(Cc4ccc5c(c4)N(Cc4ccccc4)C(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2007.06.078 | |||
| CHEMBL248231 | 93929 | 0 | None | -15 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 522 | 8 | 0 | 6 | 4.7 | Cc1ccc2c(OCCN3CCN(Cc4ccc5c(c4)N(Cc4ccccc4)C(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2007.06.078 | |||
| 10238762 | 174912 | 0 | None | -15 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 472 | 7 | 0 | 5 | 4.2 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCN(C)CC5=O)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| CHEMBL456458 | 174912 | 0 | None | -15 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 472 | 7 | 0 | 5 | 4.2 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCN(C)CC5=O)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| 10216744 | 174913 | 0 | None | -7 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 436 | 7 | 0 | 3 | 6.5 | Cc1ccc2c(OCCN3CCC(Cc4cccc(-c5ccccc5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| CHEMBL456459 | 174913 | 0 | None | -7 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 436 | 7 | 0 | 3 | 6.5 | Cc1ccc2c(OCCN3CCC(Cc4cccc(-c5ccccc5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| 7096 | 207478 | 119 | None | 7 | 4 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 162 | 1 | 1 | 2 | 1.1 | c1ccc(N2CCNCC2)cc1 | 10.1021/jm00125a020 | |||
| CHEMBL9434 | 207478 | 119 | None | 7 | 4 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 162 | 1 | 1 | 2 | 1.1 | c1ccc(N2CCNCC2)cc1 | 10.1021/jm00125a020 | |||
| 2247 | 505 | 81 | None | -35 | 42 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | |||
| 249 | 505 | 81 | None | -35 | 42 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | |||
| 2603 | 505 | 81 | None | -35 | 42 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | |||
| CHEMBL296419 | 505 | 81 | None | -35 | 42 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | |||
| DB00637 | 505 | 81 | None | -35 | 42 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | |||
| 7694 | 3511 | 36 | None | -316 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 426 | 5 | 2 | 3 | 4.8 | N#Cc1ccc2c(c1)CN(CC2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1cc2c([nH]1)cccc2 | 10.1021/jm000090i | |||
| 9910352 | 3511 | 36 | None | -316 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 426 | 5 | 2 | 3 | 4.8 | N#Cc1ccc2c(c1)CN(CC2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1cc2c([nH]1)cccc2 | 10.1021/jm000090i | |||
| CHEMBL2219578 | 3511 | 36 | None | -316 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 426 | 5 | 2 | 3 | 4.8 | N#Cc1ccc2c(c1)CN(CC2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1cc2c([nH]1)cccc2 | 10.1021/jm000090i | |||
| 10045226 | 21765 | 0 | None | -489 | 3 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 378 | 6 | 0 | 4 | 4.1 | c1ccc2c(c1)CC2CCCCN1CCN(c2cccc3c2OCCO3)CC1 | 10.1021/jm00020a020 | |||
| CHEMBL131900 | 21765 | 0 | None | -489 | 3 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 378 | 6 | 0 | 4 | 4.1 | c1ccc2c(c1)CC2CCCCN1CCN(c2cccc3c2OCCO3)CC1 | 10.1021/jm00020a020 | |||
| 9890119 | 208057 | 0 | None | -630 | 7 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 452 | 4 | 2 | 5 | 4.3 | O=S(=O)(Nc1ccc2nccc(N3CCNCC3)c2c1)c1ccc2c(Cl)cccc2c1 | 10.1016/s0960-894x(01)00558-3 | |||
| CHEMBL97596 | 208057 | 0 | None | -630 | 7 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 452 | 4 | 2 | 5 | 4.3 | O=S(=O)(Nc1ccc2nccc(N3CCNCC3)c2c1)c1ccc2c(Cl)cccc2c1 | 10.1016/s0960-894x(01)00558-3 | |||
| 11191906 | 11767 | 0 | None | -12 | 12 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 537 | 12 | 1 | 3 | 7.3 | O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1 | 10.1016/j.bmcl.2005.06.024 | |||
| CHEMBL1181665 | 11767 | 0 | None | -12 | 12 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 537 | 12 | 1 | 3 | 7.3 | O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1 | 10.1016/j.bmcl.2005.06.024 | |||
| CHEMBL187928 | 11767 | 0 | None | -12 | 12 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 537 | 12 | 1 | 3 | 7.3 | O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1 | 10.1016/j.bmcl.2005.06.024 | |||
| 9827938 | 11771 | 0 | None | -25 | 12 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 517 | 13 | 1 | 3 | 6.3 | CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1 | 10.1016/j.bmcl.2005.06.024 | |||
| CHEMBL1181680 | 11771 | 0 | None | -25 | 12 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 517 | 13 | 1 | 3 | 6.3 | CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1 | 10.1016/j.bmcl.2005.06.024 | |||
| CHEMBL188486 | 11771 | 0 | None | -25 | 12 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 517 | 13 | 1 | 3 | 6.3 | CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1 | 10.1016/j.bmcl.2005.06.024 | |||
| 10028436 | 3532 | 5 | None | -316 | 12 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 487 | 7 | 1 | 4 | 4.9 | Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 | 10.1016/s0960-894x(02)00690-x | |||
| 3237 | 3532 | 5 | None | -316 | 12 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 487 | 7 | 1 | 4 | 4.9 | Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 | 10.1016/s0960-894x(02)00690-x | |||
| CHEMBL95104 | 3532 | 5 | None | -316 | 12 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 487 | 7 | 1 | 4 | 4.9 | Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 | 10.1016/s0960-894x(02)00690-x | |||
| 10238160 | 124193 | 0 | None | -158 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 429 | 6 | 0 | 4 | 5.0 | Cc1ccc2c(OCCN3CCN(Cc4cc(Cl)ccc4Cl)CC3)cccc2n1 | 10.1021/jm049039v | |||
| CHEMBL363413 | 124193 | 0 | None | -158 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 429 | 6 | 0 | 4 | 5.0 | Cc1ccc2c(OCCN3CCN(Cc4cc(Cl)ccc4Cl)CC3)cccc2n1 | 10.1021/jm049039v | |||
| 44439167 | 90557 | 0 | None | -63 | 10 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 483 | 6 | 1 | 5 | 5.0 | Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
| CHEMBL238732 | 90557 | 0 | None | -63 | 10 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 483 | 6 | 1 | 5 | 5.0 | Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1 | 10.1016/j.bmcl.2006.11.031 | |||
| 44588772 | 185120 | 0 | None | -2 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 445 | 6 | 1 | 6 | 3.8 | Cc1ccc2c(OCC3CCN(CC(=O)c4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.110 | |||
| CHEMBL485630 | 185120 | 0 | None | -2 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 445 | 6 | 1 | 6 | 3.8 | Cc1ccc2c(OCC3CCN(CC(=O)c4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2008.08.110 | |||
| 9935387 | 99442 | 0 | None | -794 | 14 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 491 | 5 | 1 | 6 | 5.0 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1 | 10.1016/s0960-894x(02)00172-5 | |||
| CHEMBL282971 | 99442 | 0 | None | -794 | 14 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 491 | 5 | 1 | 6 | 5.0 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1 | 10.1016/s0960-894x(02)00172-5 | |||
| 9913554 | 100992 | 0 | None | -794 | 14 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 491 | 5 | 1 | 6 | 5.0 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1 | 10.1016/s0960-894x(02)00172-5 | |||
| CHEMBL29433 | 100992 | 0 | None | -794 | 14 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 491 | 5 | 1 | 6 | 5.0 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1 | 10.1016/s0960-894x(02)00172-5 | |||
| 1220 | 187 | 55 | None | -7413 | 44 | Rat | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1021/jm00384a001 | |||
| 31 | 187 | 55 | None | -7413 | 44 | Rat | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1021/jm00384a001 | |||
| 7 | 187 | 55 | None | -7413 | 44 | Rat | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1021/jm00384a001 | |||
| CHEMBL56 | 187 | 55 | None | -7413 | 44 | Rat | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1021/jm00384a001 | |||
| 71459604 | 83793 | 0 | None | -11 | 14 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 309 | 4 | 1 | 3 | 2.0 | COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1 | 10.1016/j.bmcl.2012.08.046 | |||
| CHEMBL2205811 | 83793 | 0 | None | -11 | 14 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 309 | 4 | 1 | 3 | 2.0 | COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1 | 10.1016/j.bmcl.2012.08.046 | |||
| 10767427 | 84394 | 1 | None | -1258 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 491 | 7 | 1 | 5 | 4.1 | CS(=O)(=O)c1cccc(/C=C/C(=O)N[C@H]2CC[C@H](CCN3CCc4cc(C#N)ccc4C3)CC2)c1 | 10.1021/jm000090i | |||
| CHEMBL2113352 | 84394 | 1 | None | -1258 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 491 | 7 | 1 | 5 | 4.1 | CS(=O)(=O)c1cccc(/C=C/C(=O)N[C@H]2CC[C@H](CCN3CCc4cc(C#N)ccc4C3)CC2)c1 | 10.1021/jm000090i | |||
| CHEMBL2219586 | 84394 | 1 | None | -1258 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 491 | 7 | 1 | 5 | 4.1 | CS(=O)(=O)c1cccc(/C=C/C(=O)N[C@H]2CC[C@H](CCN3CCc4cc(C#N)ccc4C3)CC2)c1 | 10.1021/jm000090i | |||
| 44304328 | 202909 | 0 | None | -4 | 2 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 311 | 6 | 0 | 2 | 4.8 | CCCN(CCC)C1CCc2c(c(OC)cc3ccccc23)C1 | 10.1016/S0960-894X(01)81009-X | |||
| CHEMBL62776 | 202909 | 0 | None | -4 | 2 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 311 | 6 | 0 | 2 | 4.8 | CCCN(CCC)C1CCc2c(c(OC)cc3ccccc23)C1 | 10.1016/S0960-894X(01)81009-X | |||
| 1220 | 187 | 55 | None | -208 | 44 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1021/jm00012a021 | |||
| 31 | 187 | 55 | None | -208 | 44 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1021/jm00012a021 | |||
| 7 | 187 | 55 | None | -208 | 44 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1021/jm00012a021 | |||
| CHEMBL56 | 187 | 55 | None | -208 | 44 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10.1021/jm00012a021 | |||
| 44376278 | 169104 | 0 | None | -2 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.1 | O=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)C12CC3CC(CC(C3)C1)C2 | 10.1016/j.bmcl.2003.11.023 | |||
| CHEMBL440008 | 169104 | 0 | None | -2 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.1 | O=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)C12CC3CC(CC(C3)C1)C2 | 10.1016/j.bmcl.2003.11.023 | |||
| 10733070 | 168468 | 0 | None | 37 | 2 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 301 | 1 | 0 | 3 | 3.6 | CN1CCN(c2cc3c4c(cccc4n2)-c2ccccc2-3)CC1 | 10.1021/jm981112s | |||
| CHEMBL43512 | 168468 | 0 | None | 37 | 2 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 301 | 1 | 0 | 3 | 3.6 | CN1CCN(c2cc3c4c(cccc4n2)-c2ccccc2-3)CC1 | 10.1021/jm981112s | |||
| CHEMBL5081379 | 214746 | 0 | None | -97 | 9 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | None | None | None | CCCNCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
| 11727140 | 109393 | 0 | None | -58 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 326 | 3 | 2 | 3 | 3.5 | CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCCC4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL321967 | 109393 | 0 | None | -58 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 326 | 3 | 2 | 3 | 3.5 | CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCCC4)nc23)CC1 | 10.1021/jm030020m | |||
| 21830793 | 91835 | 10 | None | -4265 | 45 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 373 | 7 | 0 | 8 | 0.6 | COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 | 10.1016/j.bmc.2013.05.050 | |||
| CHEMBL2413154 | 91835 | 10 | None | -4265 | 45 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 373 | 7 | 0 | 8 | 0.6 | COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 | 10.1016/j.bmc.2013.05.050 | |||
| 10338821 | 20799 | 0 | None | -1445 | 2 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 364 | 5 | 0 | 4 | 3.7 | c1ccc2c(c1)CC2CCCN1CCN(c2cccc3c2OCCO3)CC1 | 10.1021/jm00020a020 | |||
| CHEMBL130976 | 20799 | 0 | None | -1445 | 2 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 364 | 5 | 0 | 4 | 3.7 | c1ccc2c(c1)CC2CCCN1CCN(c2cccc3c2OCCO3)CC1 | 10.1021/jm00020a020 | |||
| 44376541 | 165388 | 0 | None | -7 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 464 | 6 | 2 | 3 | 5.4 | O=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2003.11.023 | |||
| CHEMBL423789 | 165388 | 0 | None | -7 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 464 | 6 | 2 | 3 | 5.4 | O=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2003.11.023 | |||
| 59636738 | 126211 | 0 | None | - | 1 | Chinese hamster | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 408 | 6 | 0 | 6 | 2.9 | COc1ccnc(CCN2CCN(c3cccc4cc(C(=O)N(C)C)oc34)CC2)c1 | nan | |||
| CHEMBL3650032 | 126211 | 0 | None | - | 1 | Chinese hamster | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 408 | 6 | 0 | 6 | 2.9 | COc1ccnc(CCN2CCN(c3cccc4cc(C(=O)N(C)C)oc34)CC2)c1 | nan | |||
| 11393666 | 192986 | 0 | None | -1698 | 19 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 340 | 2 | 1 | 2 | 4.6 | CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1 | 10.1016/j.bmcl.2022.128879 | |||
| CHEMBL5201983 | 192986 | 0 | None | -1698 | 19 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 340 | 2 | 1 | 2 | 4.6 | CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1 | 10.1016/j.bmcl.2022.128879 | |||
| CHEMBL5222597 | 192986 | 0 | None | -1698 | 19 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 340 | 2 | 1 | 2 | 4.6 | CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1 | 10.1016/j.bmcl.2022.128879 | |||
| 283 | 3130 | 57 | None | -6606 | 12 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 393 | 5 | 0 | 5 | 3.3 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2 | 10.1021/jm00384a001 | |||
| 4847 | 3130 | 57 | None | -6606 | 12 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 393 | 5 | 0 | 5 | 3.3 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2 | 10.1021/jm00384a001 | |||
| CHEMBL18331 | 3130 | 57 | None | -6606 | 12 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 393 | 5 | 0 | 5 | 3.3 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2 | 10.1021/jm00384a001 | |||
| 76322956 | 106204 | 0 | None | -1 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 233 | 4 | 1 | 2 | 3.0 | CNC(C)COc1cc(Cl)ccc1Cl | 10.1007/s00044-009-9164-1 | |||
| CHEMBL2260927 | 106204 | 0 | None | -1 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 233 | 4 | 1 | 2 | 3.0 | CNC(C)COc1cc(Cl)ccc1Cl | 10.1007/s00044-009-9164-1 | |||
| CHEMBL3138744 | 106204 | 0 | None | -1 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 233 | 4 | 1 | 2 | 3.0 | CNC(C)COc1cc(Cl)ccc1Cl | 10.1007/s00044-009-9164-1 | |||
| 9826761 | 112022 | 0 | None | 1 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 487 | 6 | 1 | 6 | 3.8 | Cn1ncc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | |||
| CHEMBL328940 | 112022 | 0 | None | 1 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 487 | 6 | 1 | 6 | 3.8 | Cn1ncc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | |||
| 125957 | 120160 | 8 | None | -1 | 2 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 256 | 0 | 1 | 2 | 2.4 | FC(F)(F)c1ccc2c(c1)N1CCNCC1CC2 | 10.1021/jm00145a017 | |||
| CHEMBL351530 | 120160 | 8 | None | -1 | 2 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 256 | 0 | 1 | 2 | 2.4 | FC(F)(F)c1ccc2c(c1)N1CCNCC1CC2 | 10.1021/jm00145a017 | |||
| 10432483 | 23265 | 0 | None | -426 | 3 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 424 | 6 | 0 | 6 | 3.7 | COc1cc2c(cc1OC)C(CCN1CCN(c3cccc4c3OCCO4)CC1)CC2 | 10.1021/jm00020a020 | |||
| CHEMBL133188 | 23265 | 0 | None | -426 | 3 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 424 | 6 | 0 | 6 | 3.7 | COc1cc2c(cc1OC)C(CCN1CCN(c3cccc4c3OCCO4)CC1)CC2 | 10.1021/jm00020a020 | |||
| 10917920 | 111446 | 0 | None | -85 | 9 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 487 | 6 | 1 | 6 | 3.8 | Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | |||
| CHEMBL327527 | 111446 | 0 | None | -85 | 9 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 487 | 6 | 1 | 6 | 3.8 | Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | |||
| 44376272 | 120229 | 0 | None | -7 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 430 | 6 | 2 | 3 | 4.8 | S=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)c1ccccc1 | 10.1016/j.bmcl.2003.11.023 | |||
| CHEMBL352181 | 120229 | 0 | None | -7 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 430 | 6 | 2 | 3 | 4.8 | S=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)c1ccccc1 | 10.1016/j.bmcl.2003.11.023 | |||
| 10130620 | 103649 | 3 | None | -64 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 216 | 2 | 1 | 2 | 2.5 | CC(C)(C)c1ccc(CC2=NCCN2)cc1 | 10.1021/jm970513p | |||
| CHEMBL308727 | 103649 | 3 | None | -64 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 216 | 2 | 1 | 2 | 2.5 | CC(C)(C)c1ccc(CC2=NCCN2)cc1 | 10.1021/jm970513p | |||
| 9998873 | 19566 | 0 | None | -1047 | 2 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 364 | 4 | 0 | 4 | 3.4 | c1ccc2c(c1)CC(CCN1CCN(c3cccc4c3OCCO4)CC1)C2 | 10.1021/jm00020a020 | |||
| CHEMBL129993 | 19566 | 0 | None | -1047 | 2 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 364 | 4 | 0 | 4 | 3.4 | c1ccc2c(c1)CC(CCN1CCN(c3cccc4c3OCCO4)CC1)C2 | 10.1021/jm00020a020 | |||
| 72550645 | 114089 | 0 | None | 1 | 8 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 505 | 11 | 1 | 4 | 6.0 | COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1 | 10.1016/j.bmc.2014.07.026 | |||
| CHEMBL3326993 | 114089 | 0 | None | 1 | 8 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 505 | 11 | 1 | 4 | 6.0 | COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1 | 10.1016/j.bmc.2014.07.026 | |||
| 59636779 | 126214 | 0 | None | - | 1 | Chinese hamster | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 446 | 5 | 0 | 5 | 3.9 | CN(C)C(=O)c1cc2cccc(N3CCN(CCc4cccc(C(F)(F)F)n4)CC3)c2o1 | nan | |||
| CHEMBL3650035 | 126214 | 0 | None | - | 1 | Chinese hamster | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 446 | 5 | 0 | 5 | 3.9 | CN(C)C(=O)c1cc2cccc(N3CCN(CCc4cccc(C(F)(F)F)n4)CC3)c2o1 | nan | |||
| 5 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00018a020 | |||
| 5202 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00018a020 | |||
| CHEMBL39 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00018a020 | |||
| DB08839 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00018a020 | |||
| 20810 | 9185 | 22 | None | -5 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 202 | 3 | 2 | 2 | 1.9 | CC(=O)c1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
| CHEMBL110317 | 9185 | 22 | None | -5 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 202 | 3 | 2 | 2 | 1.9 | CC(=O)c1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
| 59636713 | 125696 | 0 | None | - | 1 | Chinese hamster | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 466 | 7 | 1 | 7 | 3.4 | N#Cc1ccc(CNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)cn1 | nan | |||
| CHEMBL3647278 | 125696 | 0 | None | - | 1 | Chinese hamster | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 466 | 7 | 1 | 7 | 3.4 | N#Cc1ccc(CNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)cn1 | nan | |||
| 2543 | 3707 | 68 | None | -3 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(03)00779-0 | |||
| 5358 | 3707 | 68 | None | -3 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(03)00779-0 | |||
| 54 | 3707 | 68 | None | -3 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(03)00779-0 | |||
| CHEMBL128 | 3707 | 68 | None | -3 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(03)00779-0 | |||
| DB00669 | 3707 | 68 | None | -3 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/s0960-894x(03)00779-0 | |||
| 2543 | 3707 | 68 | None | -3 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/j.bmcl.2003.11.023 | |||
| 5358 | 3707 | 68 | None | -3 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/j.bmcl.2003.11.023 | |||
| 54 | 3707 | 68 | None | -3 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/j.bmcl.2003.11.023 | |||
| CHEMBL128 | 3707 | 68 | None | -3 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/j.bmcl.2003.11.023 | |||
| DB00669 | 3707 | 68 | None | -3 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/j.bmcl.2003.11.023 | |||
| 59636722 | 126221 | 0 | None | - | 1 | Chinese hamster | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 408 | 6 | 0 | 6 | 2.9 | COc1cccnc1CCN1CCN(c2cccc3cc(C(=O)N(C)C)oc23)CC1 | nan | |||
| CHEMBL3650041 | 126221 | 0 | None | - | 1 | Chinese hamster | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 408 | 6 | 0 | 6 | 2.9 | COc1cccnc1CCN1CCN(c2cccc3cc(C(=O)N(C)C)oc23)CC1 | nan | |||
| 188006 | 5468 | 14 | None | -2 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 188 | 3 | 2 | 1 | 2.2 | CCc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
| CHEMBL107511 | 5468 | 14 | None | -2 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 188 | 3 | 2 | 1 | 2.2 | CCc1ccc2[nH]cc(CCN)c2c1 | 10.1021/jm950498t | |||
| 44402893 | 69809 | 0 | None | 63 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 470 | 4 | 1 | 5 | 4.8 | COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(C(=O)c1ccc(-c3cc(C)ncc3C)cc1)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| CHEMBL193616 | 69809 | 0 | None | 63 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 470 | 4 | 1 | 5 | 4.8 | COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(C(=O)c1ccc(-c3cc(C)ncc3C)cc1)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| 71458050 | 79017 | 0 | None | 3 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 410 | 5 | 0 | 6 | 2.5 | COc1cc2c(cc1N1CCN(C)CC1)N(C(=O)Cc1cccc([N+](=O)[O-])c1)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| CHEMBL2113097 | 79017 | 0 | None | 3 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 410 | 5 | 0 | 6 | 2.5 | COc1cc2c(cc1N1CCN(C)CC1)N(C(=O)Cc1cccc([N+](=O)[O-])c1)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| 44402888 | 140532 | 0 | None | 25 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 446 | 3 | 1 | 4 | 4.6 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Nc1cccc(Cl)c1F)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| CHEMBL381035 | 140532 | 0 | None | 25 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 446 | 3 | 1 | 4 | 4.6 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Nc1cccc(Cl)c1F)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| 44402871 | 168597 | 0 | None | 10 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 462 | 3 | 1 | 4 | 5.1 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Nc1cccc(Cl)c1Cl)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| CHEMBL435936 | 168597 | 0 | None | 10 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 462 | 3 | 1 | 4 | 5.1 | COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(C(=O)Nc1cccc(Cl)c1Cl)CC2 | 10.1016/j.bmcl.2005.07.085 | |||
| 49852105 | 56388 | 0 | None | -15 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 346 | 4 | 1 | 4 | 3.5 | Cc1ccc2c(N3CCN(CCc4cccc(N)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| CHEMBL1631534 | 56388 | 0 | None | -15 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 346 | 4 | 1 | 4 | 3.5 | Cc1ccc2c(N3CCN(CCc4cccc(N)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
| 44443093 | 154693 | 0 | None | -15 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 446 | 6 | 0 | 6 | 3.1 | Cc1ccc2c(OCCN3CCN(Cc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2007.06.078 | |||
| CHEMBL399719 | 154693 | 0 | None | -15 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 446 | 6 | 0 | 6 | 3.1 | Cc1ccc2c(OCCN3CCN(Cc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1 | 10.1016/j.bmcl.2007.06.078 | |||
| 10288132 | 177017 | 0 | None | -7 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 437 | 7 | 0 | 4 | 5.9 | Cc1ccc2c(OCCN3CCC(Cc4cccc(-c5ccncc5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| CHEMBL462916 | 177017 | 0 | None | -7 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 437 | 7 | 0 | 4 | 5.9 | Cc1ccc2c(OCCN3CCC(Cc4cccc(-c5ccncc5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| 10127877 | 189562 | 0 | None | -12 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 472 | 7 | 0 | 5 | 5.0 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCN(C)CC5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| CHEMBL514429 | 189562 | 0 | None | -12 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 472 | 7 | 0 | 5 | 5.0 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCN(C)CC5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| 44580741 | 192670 | 0 | None | -15 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 416 | 4 | 1 | 5 | 3.6 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)[C@H](C)C3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
| CHEMBL521873 | 192670 | 0 | None | -15 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 416 | 4 | 1 | 5 | 3.6 | Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)[C@H](C)C3)cccc2n1 | 10.1016/j.bmcl.2008.08.084 | |||
| 75 | 3514 | 7 | None | -3 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 497 | 3 | 1 | 4 | 5.9 | CN1CCN(CC1)c1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(c2c1cccc2)c1ccncc1 | 10.1016/j.bmcl.2005.06.042 | |||
| 9870500 | 3514 | 7 | None | -3 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 497 | 3 | 1 | 4 | 5.9 | CN1CCN(CC1)c1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(c2c1cccc2)c1ccncc1 | 10.1016/j.bmcl.2005.06.042 | |||
| CHEMBL191971 | 3514 | 7 | None | -3 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 497 | 3 | 1 | 4 | 5.9 | CN1CCN(CC1)c1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(c2c1cccc2)c1ccncc1 | 10.1016/j.bmcl.2005.06.042 | |||
| 44404264 | 72542 | 0 | None | 1 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 505 | 4 | 1 | 7 | 4.2 | CCc1c(C(=O)N2CCc3cc4ccnc(N5C[C@H](C)N[C@H](C)C5)c4cc32)cnn1-c1ccc(C#N)cc1 | 10.1016/j.bmcl.2005.06.042 | |||
| CHEMBL199144 | 72542 | 0 | None | 1 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 505 | 4 | 1 | 7 | 4.2 | CCc1c(C(=O)N2CCc3cc4ccnc(N5C[C@H](C)N[C@H](C)C5)c4cc32)cnn1-c1ccc(C#N)cc1 | 10.1016/j.bmcl.2005.06.042 | |||
| 10403999 | 60050 | 0 | None | -27 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 324 | 4 | 1 | 2 | 5.3 | CC1CCC(C)N1CCc1c[nH]c2ccc(-c3cccs3)cc12 | 10.1016/s0960-894x(00)00133-5 | |||
| CHEMBL173656 | 60050 | 0 | None | -27 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 324 | 4 | 1 | 2 | 5.3 | CC1CCC(C)N1CCc1c[nH]c2ccc(-c3cccs3)cc12 | 10.1016/s0960-894x(00)00133-5 | |||
| 10068933 | 103801 | 0 | None | -3 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 389 | 8 | 1 | 4 | 4.5 | COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1CCCN(C)C | 10.1021/jm9702948 | |||
| CHEMBL309021 | 103801 | 0 | None | -3 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 389 | 8 | 1 | 4 | 4.5 | COc1ccc(C(=O)Nc2ccc(-c3ccncc3)cc2)cc1CCCN(C)C | 10.1021/jm9702948 | |||
| 168293874 | 192179 | 0 | None | -16 | 11 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 312 | 2 | 3 | 3 | 3.3 | COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1 | 10.1021/acsmedchemlett.1c00694 | |||
| CHEMBL5204071 | 192179 | 0 | None | -16 | 11 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 312 | 2 | 3 | 3 | 3.3 | COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1 | 10.1021/acsmedchemlett.1c00694 | |||
| 73350823 | 102530 | 0 | None | -45 | 9 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 509 | 8 | 1 | 5 | 3.7 | O=C(Cc1ccc(OC2CCNCC2)cc1OCCF)N1CCC(N2C(=O)CCc3ccccc32)CC1 | 10.1016/j.bmcl.2013.07.045 | |||
| CHEMBL2424668 | 102530 | 0 | None | -45 | 9 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 509 | 8 | 1 | 5 | 3.7 | O=C(Cc1ccc(OC2CCNCC2)cc1OCCF)N1CCC(N2C(=O)CCc3ccccc32)CC1 | 10.1016/j.bmcl.2013.07.045 | |||
| CHEMBL3040578 | 102530 | 0 | None | -45 | 9 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 509 | 8 | 1 | 5 | 3.7 | O=C(Cc1ccc(OC2CCNCC2)cc1OCCF)N1CCC(N2C(=O)CCc3ccccc32)CC1 | 10.1016/j.bmcl.2013.07.045 | |||
| 10068239 | 22471 | 0 | None | -257 | 2 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 378 | 4 | 0 | 4 | 4.1 | c1ccc2c(c1)CCCC2CCN1CCN(c2cccc3c2OCCO3)CC1 | 10.1021/jm00020a020 | |||
| CHEMBL132514 | 22471 | 0 | None | -257 | 2 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 378 | 4 | 0 | 4 | 4.1 | c1ccc2c(c1)CCCC2CCN1CCN(c2cccc3c2OCCO3)CC1 | 10.1021/jm00020a020 | |||
| 10091445 | 118485 | 0 | None | -316 | 3 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 384 | 4 | 0 | 4 | 4.0 | Clc1cccc2c1CC2CCN1CCN(c2cccc3c2OCCO3)CC1 | 10.1021/jm00020a020 | |||
| CHEMBL341390 | 118485 | 0 | None | -316 | 3 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 384 | 4 | 0 | 4 | 4.0 | Clc1cccc2c1CC2CCN1CCN(c2cccc3c2OCCO3)CC1 | 10.1021/jm00020a020 | |||
| 73213195 | 104459 | 0 | None | -24 | 12 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 288 | 0 | 0 | 2 | 3.6 | CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
| CHEMBL3104092 | 104459 | 0 | None | -24 | 12 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 288 | 0 | 0 | 2 | 3.6 | CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
| 76312088 | 106211 | 0 | None | 3 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 321 | 4 | 1 | 2 | 3.2 | CNC(C)COc1c(Br)cccc1Br | 10.1007/s00044-009-9164-1 | |||
| CHEMBL2260929 | 106211 | 0 | None | 3 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 321 | 4 | 1 | 2 | 3.2 | CNC(C)COc1c(Br)cccc1Br | 10.1007/s00044-009-9164-1 | |||
| CHEMBL3138771 | 106211 | 0 | None | 3 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 321 | 4 | 1 | 2 | 3.2 | CNC(C)COc1c(Br)cccc1Br | 10.1007/s00044-009-9164-1 | |||
| 9816035 | 204133 | 1 | None | -104 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 230 | 2 | 1 | 2 | 2.8 | Cc1cc(C(C)(C)C)ccc1CC1=NCCN1 | 10.1021/jm970513p | |||
| CHEMBL70409 | 204133 | 1 | None | -104 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 230 | 2 | 1 | 2 | 2.8 | Cc1cc(C(C)(C)C)ccc1CC1=NCCN1 | 10.1021/jm970513p | |||
| 71457690 | 83798 | 0 | None | -6 | 5 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 280 | 3 | 1 | 3 | 1.4 | OC12C3C4CC5C6C4C1C6C(C53)N2CCc1cccnc1 | 10.1016/j.bmcl.2012.08.046 | |||
| CHEMBL2205817 | 83798 | 0 | None | -6 | 5 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 280 | 3 | 1 | 3 | 1.4 | OC12C3C4CC5C6C4C1C6C(C53)N2CCc1cccnc1 | 10.1016/j.bmcl.2012.08.046 | |||
| 10266598 | 120371 | 1 | None | -37 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 296 | 4 | 1 | 2 | 4.5 | c1csc(-c2ccc3[nH]cc(CCN4CCCC4)c3c2)c1 | 10.1016/s0960-894x(00)00133-5 | |||
| CHEMBL353256 | 120371 | 1 | None | -37 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 296 | 4 | 1 | 2 | 4.5 | c1csc(-c2ccc3[nH]cc(CCN4CCCC4)c3c2)c1 | 10.1016/s0960-894x(00)00133-5 | |||
| 73213195 | 104459 | 0 | None | -24 | 12 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 288 | 0 | 0 | 2 | 3.6 | CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
| CHEMBL3104092 | 104459 | 0 | None | -24 | 12 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 288 | 0 | 0 | 2 | 3.6 | CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
| 9947817 | 5047 | 0 | None | -131 | 9 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 286 | 3 | 2 | 3 | 2.7 | CCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| CHEMBL105261 | 5047 | 0 | None | -131 | 9 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 286 | 3 | 2 | 3 | 2.7 | CCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| 9863333 | 204365 | 0 | None | -5128 | 10 | Western lowland gorilla | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 352 | 5 | 0 | 4 | 3.5 | COc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1 | 10.1021/jm980137o | |||
| CHEMBL71724 | 204365 | 0 | None | -5128 | 10 | Western lowland gorilla | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 352 | 5 | 0 | 4 | 3.5 | COc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1 | 10.1021/jm980137o | |||
| 899056 | 63066 | 4 | None | - | 1 | Rat | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 204 | 3 | 2 | 2 | 2.1 | COc1ccc2c(C[C@H](C)N)c[nH]c2c1 | 10.1021/jm00402a026 | |||
| CHEMBL1788282 | 63066 | 4 | None | - | 1 | Rat | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 204 | 3 | 2 | 2 | 2.1 | COc1ccc2c(C[C@H](C)N)c[nH]c2c1 | 10.1021/jm00402a026 | |||
| 44461443 | 205353 | 0 | None | -5 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 414 | 5 | 1 | 3 | 4.8 | NC(=O)c1ccc2c(c1)CCOC2CCN1CCC(c2cccc3ccccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
| CHEMBL79693 | 205353 | 0 | None | -5 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 414 | 5 | 1 | 3 | 4.8 | NC(=O)c1ccc2c(c1)CCOC2CCN1CCC(c2cccc3ccccc23)CC1 | 10.1016/j.bmcl.2004.03.003 | |||
| 66847540 | 126213 | 0 | None | - | 1 | Chinese hamster | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 403 | 5 | 0 | 6 | 2.8 | CN(C)C(=O)c1cc2cccc(N3CCN(CCc4cc(C#N)ccn4)CC3)c2o1 | nan | |||
| CHEMBL3650034 | 126213 | 0 | None | - | 1 | Chinese hamster | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 403 | 5 | 0 | 6 | 2.8 | CN(C)C(=O)c1cc2cccc(N3CCN(CCc4cc(C#N)ccn4)CC3)c2o1 | nan | |||
| 14975318 | 77243 | 0 | None | -144 | 2 | Rat | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 410 | 5 | 0 | 4 | 3.8 | COc1cccc2c1[C@@H]1CCN(CCCN3C(=O)CC4(CCCC4)CC3=O)C[C@H]1C2 | 10.1021/jm00027a013 | |||
| CHEMBL2079596 | 77243 | 0 | None | -144 | 2 | Rat | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 410 | 5 | 0 | 4 | 3.8 | COc1cccc2c1[C@@H]1CCN(CCCN3C(=O)CC4(CCCC4)CC3=O)C[C@H]1C2 | 10.1021/jm00027a013 | |||
| CHEMBL5074190 | 214314 | 0 | None | -29 | 9 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | None | None | None | COc1ccccc1-c1cc(CCN(C)C)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||||
| 70530 | 96957 | 104 | None | -2 | 3 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 178 | 1 | 2 | 3 | 0.8 | Oc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
| CHEMBL266250 | 96957 | 104 | None | -2 | 3 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 178 | 1 | 2 | 3 | 0.8 | Oc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
| 50878551 | 90745 | 61 | None | -7 | 18 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 270 | 8 | 1 | 2 | 3.4 | C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 | 10.1016/j.bmcl.2015.12.053 | |||
| CHEMBL2391541 | 90745 | 61 | None | -7 | 18 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 270 | 8 | 1 | 2 | 3.4 | C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 | 10.1016/j.bmcl.2015.12.053 | |||
| 1355 | 2011 | 88 | None | -1 | 16 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 196 | 1 | 1 | 2 | 1.8 | Clc1cccc(c1)N1CCNCC1 | 10.1021/jm00384a001 | |||
| 142 | 2011 | 88 | None | -1 | 16 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 196 | 1 | 1 | 2 | 1.8 | Clc1cccc(c1)N1CCNCC1 | 10.1021/jm00384a001 | |||
| CHEMBL478 | 2011 | 88 | None | -1 | 16 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 196 | 1 | 1 | 2 | 1.8 | Clc1cccc(c1)N1CCNCC1 | 10.1021/jm00384a001 | |||
| DB12110 | 2011 | 88 | None | -1 | 16 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 196 | 1 | 1 | 2 | 1.8 | Clc1cccc(c1)N1CCNCC1 | 10.1021/jm00384a001 | |||
| 15724480 | 119579 | 0 | None | -117 | 3 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 452 | 7 | 0 | 5 | 4.4 | CC(C)Oc1ccccc1N1CCN(Cc2ccc(CN3CCCCCCC3=O)n2C)CC1 | 10.1021/jm00081a018 | |||
| CHEMBL346168 | 119579 | 0 | None | -117 | 3 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 452 | 7 | 0 | 5 | 4.4 | CC(C)Oc1ccccc1N1CCN(Cc2ccc(CN3CCCCCCC3=O)n2C)CC1 | 10.1021/jm00081a018 | |||
| 11111280 | 109198 | 0 | None | -38 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 364 | 4 | 2 | 4 | 3.6 | COc1ccccc1C(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| CHEMBL321562 | 109198 | 0 | None | -38 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 364 | 4 | 2 | 4 | 3.6 | COc1ccccc1C(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| 76322958 | 106224 | 0 | None | -1 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 257 | 6 | 1 | 3 | 3.5 | CNC(C)COc1cccc(Oc2ccccc2)c1 | 10.1007/s00044-009-9164-1 | |||
| CHEMBL2260930 | 106224 | 0 | None | -1 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 257 | 6 | 1 | 3 | 3.5 | CNC(C)COc1cccc(Oc2ccccc2)c1 | 10.1007/s00044-009-9164-1 | |||
| CHEMBL3138809 | 106224 | 0 | None | -1 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 257 | 6 | 1 | 3 | 3.5 | CNC(C)COc1cccc(Oc2ccccc2)c1 | 10.1007/s00044-009-9164-1 | |||
| 86221574 | 166687 | 2 | None | -95 | 5 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 375 | 5 | 2 | 2 | 3.4 | O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccccc2)CC1 | 10.1039/C8MD00204E | |||
| CHEMBL4282117 | 166687 | 2 | None | -95 | 5 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 375 | 5 | 2 | 2 | 3.4 | O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccccc2)CC1 | 10.1039/C8MD00204E | |||
| 11145333 | 164595 | 0 | None | -6 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 484 | 6 | 1 | 5 | 4.4 | O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4ncccn4)cc23)CC1 | 10.1021/jm020938y | |||
| CHEMBL421573 | 164595 | 0 | None | -6 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 484 | 6 | 1 | 5 | 4.4 | O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4ncccn4)cc23)CC1 | 10.1021/jm020938y | |||
| 10513501 | 102619 | 0 | None | 14 | 2 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 227 | 1 | 1 | 2 | 2.7 | COc1cc2ccccc2c2c1CC(N)CC2 | 10.1016/S0960-894X(01)81009-X | |||
| CHEMBL304210 | 102619 | 0 | None | 14 | 2 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 227 | 1 | 1 | 2 | 2.7 | COc1cc2ccccc2c2c1CC(N)CC2 | 10.1016/S0960-894X(01)81009-X | |||
| 44376362 | 164896 | 0 | None | -10 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 295 | 4 | 2 | 2 | 3.2 | C1=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CCNC1 | 10.1016/j.bmcl.2003.11.023 | |||
| CHEMBL422192 | 164896 | 0 | None | -10 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 295 | 4 | 2 | 2 | 3.2 | C1=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CCNC1 | 10.1016/j.bmcl.2003.11.023 | |||
| 44286629 | 168148 | 0 | None | -245 | 3 | Rat | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 437 | 5 | 0 | 5 | 5.0 | CN1CCN(c2nc3ccccc3c(-c3ccccc3)c2COC(=O)c2ccccc2)CC1 | 10.1021/jm981112s | |||
| CHEMBL43304 | 168148 | 0 | None | -245 | 3 | Rat | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 437 | 5 | 0 | 5 | 5.0 | CN1CCN(c2nc3ccccc3c(-c3ccccc3)c2COC(=O)c2ccccc2)CC1 | 10.1021/jm981112s | |||
| 9845181 | 208161 | 3 | None | -5495 | 13 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 423 | 4 | 0 | 4 | 3.3 | C[C@H](CN1CCN(c2cc(F)c(F)cc2F)CC1)N1C(=O)CC2(CCCC2)CC1=O | 10.1021/jm020938y | |||
| CHEMBL98241 | 208161 | 3 | None | -5495 | 13 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 423 | 4 | 0 | 4 | 3.3 | C[C@H](CN1CCN(c2cc(F)c(F)cc2F)CC1)N1C(=O)CC2(CCCC2)CC1=O | 10.1021/jm020938y | |||
| 21048816 | 75500 | 0 | None | -1096 | 5 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 385 | 7 | 0 | 3 | 4.9 | CC(C)(CCCN1CCCC(c2ccccc2)C1)S(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2005.11.067 | |||
| CHEMBL204269 | 75500 | 0 | None | -1096 | 5 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 385 | 7 | 0 | 3 | 4.9 | CC(C)(CCCN1CCCC(c2ccccc2)C1)S(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2005.11.067 | |||
| 10023444 | 116704 | 0 | None | -117 | 2 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 392 | 4 | 0 | 4 | 4.5 | c1ccc2c(c1)CCCCC2CCN1CCN(c2cccc3c2OCCO3)CC1 | 10.1021/jm00020a020 | |||
| CHEMBL337279 | 116704 | 0 | None | -117 | 2 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 392 | 4 | 0 | 4 | 4.5 | c1ccc2c(c1)CCCCC2CCN1CCN(c2cccc3c2OCCO3)CC1 | 10.1021/jm00020a020 | |||
| 14083210 | 60322 | 2 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 204 | 3 | 2 | 2 | 2.1 | COc1cccc2[nH]cc(C[C@@H](C)N)c12 | 10.1021/jm00402a026 | |||
| CHEMBL1744072 | 60322 | 2 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 204 | 3 | 2 | 2 | 2.1 | COc1cccc2[nH]cc(C[C@@H](C)N)c12 | 10.1021/jm00402a026 | |||
| 44581973 | 175601 | 0 | None | -363 | 10 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 513 | 6 | 2 | 6 | 4.6 | Cc1ccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cc1NC(=O)c1ccc(-c2ccccc2)cc1 | 10.1021/jm800962k | |||
| CHEMBL458002 | 175601 | 0 | None | -363 | 10 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 513 | 6 | 2 | 6 | 4.6 | Cc1ccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cc1NC(=O)c1ccc(-c2ccccc2)cc1 | 10.1021/jm800962k | |||
| 71061724 | 145552 | 0 | None | -7 | 5 | Mouse | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 386 | 5 | 0 | 4 | 3.0 | O=C(CN1CCO[C@H](COc2cccc(Cl)c2)C1)N1CCc2ccccc21 | nan | |||
| CHEMBL3915107 | 145552 | 0 | None | -7 | 5 | Mouse | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 386 | 5 | 0 | 4 | 3.0 | O=C(CN1CCO[C@H](COc2cccc(Cl)c2)C1)N1CCc2ccccc21 | nan | |||
| 10356544 | 203991 | 0 | None | -61 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 284 | 5 | 1 | 1 | 4.5 | CCCN(CCC)C1CCc2ccc3[nH]cc(C)c3c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL69562 | 203991 | 0 | None | -61 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 284 | 5 | 1 | 1 | 4.5 | CCCN(CCC)C1CCc2ccc3[nH]cc(C)c3c2C1 | 10.1021/jm00012a021 | |||
| 24882193 | 188649 | 0 | None | -263 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 770 | 14 | 4 | 4 | 10.4 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | 10.1021/jm7011722 | |||
| CHEMBL503468 | 188649 | 0 | None | -263 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 770 | 14 | 4 | 4 | 10.4 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | 10.1021/jm7011722 | |||
| 11270107 | 68246 | 0 | None | -39 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 420 | 7 | 0 | 6 | 4.0 | Cc1ccc2c(OCCN3CCN(Cc4ccc(C)c([N+](=O)[O-])c4)CC3)cccc2n1 | 10.1021/jm049039v | |||
| CHEMBL191605 | 68246 | 0 | None | -39 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 420 | 7 | 0 | 6 | 4.0 | Cc1ccc2c(OCCN3CCN(Cc4ccc(C)c([N+](=O)[O-])c4)CC3)cccc2n1 | 10.1021/jm049039v | |||
| 44581235 | 177016 | 0 | None | -25 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 521 | 8 | 0 | 5 | 5.0 | Cc1ccc2c(OCCN3CCC(Cc4cccc(C5CCN(S(C)(=O)=O)CC5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| CHEMBL462915 | 177016 | 0 | None | -25 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 521 | 8 | 0 | 5 | 5.0 | Cc1ccc2c(OCCN3CCC(Cc4cccc(C5CCN(S(C)(=O)=O)CC5)c4)CC3)cccc2n1 | 10.1016/j.bmcl.2008.11.052 | |||
| 10341516 | 115522 | 0 | None | -251 | 2 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 410 | 6 | 0 | 6 | 3.3 | COc1cc2c(cc1OC)C(CCN1CCN(c3cccc4c3OCCO4)CC1)C2 | 10.1021/jm00020a020 | |||
| CHEMBL335297 | 115522 | 0 | None | -251 | 2 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 410 | 6 | 0 | 6 | 3.3 | COc1cc2c(cc1OC)C(CCN1CCN(c3cccc4c3OCCO4)CC1)C2 | 10.1021/jm00020a020 | |||
| 276 | 3513 | 50 | None | -537 | 13 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 451 | 5 | 2 | 6 | 4.1 | COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl | 10.1021/jm980532e | |||
| 5312149 | 3513 | 50 | None | -537 | 13 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 451 | 5 | 2 | 6 | 4.1 | COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl | 10.1021/jm980532e | |||
| CHEMBL431298 | 3513 | 50 | None | -537 | 13 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 451 | 5 | 2 | 6 | 4.1 | COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl | 10.1021/jm980532e | |||
| 6918648 | 101559 | 1 | None | -1288 | 14 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 465 | 5 | 1 | 6 | 4.4 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 | 10.1021/jm980532e | |||
| CHEMBL29846 | 101559 | 1 | None | -1288 | 14 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 465 | 5 | 1 | 6 | 4.4 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 | 10.1021/jm980532e | |||
| 10161027 | 91976 | 0 | None | -39 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 449 | 6 | 1 | 5 | 4.3 | Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)ccc(F)c2n1 | 10.1016/j.bmcl.2006.11.031 | |||
| CHEMBL241499 | 91976 | 0 | None | -39 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 449 | 6 | 1 | 5 | 4.3 | Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)ccc(F)c2n1 | 10.1016/j.bmcl.2006.11.031 | |||
| 276 | 3513 | 50 | None | -537 | 13 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 451 | 5 | 2 | 6 | 4.1 | COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl | 10.1016/s0960-894x(02)00172-5 | |||
| 5312149 | 3513 | 50 | None | -537 | 13 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 451 | 5 | 2 | 6 | 4.1 | COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl | 10.1016/s0960-894x(02)00172-5 | |||
| CHEMBL431298 | 3513 | 50 | None | -537 | 13 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 451 | 5 | 2 | 6 | 4.1 | COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl | 10.1016/s0960-894x(02)00172-5 | |||
| 6918648 | 101559 | 1 | None | -1288 | 14 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 465 | 5 | 1 | 6 | 4.4 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 | 10.1016/s0960-894x(02)00172-5 | |||
| CHEMBL29846 | 101559 | 1 | None | -1288 | 14 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 465 | 5 | 1 | 6 | 4.4 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 | 10.1016/s0960-894x(02)00172-5 | |||
| 19066205 | 11382 | 0 | None | 8 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 439 | 5 | 1 | 6 | 2.8 | COc1cccc(N2CCN(C(=O)Nc3ccc(OC)c(N4CCN(C)CC4)c3)CC2)c1 | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL108722 | 11382 | 0 | None | 8 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 439 | 5 | 1 | 6 | 2.8 | COc1cccc(N2CCN(C(=O)Nc3ccc(OC)c(N4CCN(C)CC4)c3)CC2)c1 | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL1179986 | 11382 | 0 | None | 8 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 439 | 5 | 1 | 6 | 2.8 | COc1cccc(N2CCN(C(=O)Nc3ccc(OC)c(N4CCN(C)CC4)c3)CC2)c1 | 10.1016/S0960-894X(97)10164-0 | |||
| 2543 | 3707 | 68 | None | -17 | 32 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | nan | |||
| 5358 | 3707 | 68 | None | -17 | 32 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | nan | |||
| 54 | 3707 | 68 | None | -17 | 32 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | nan | |||
| CHEMBL128 | 3707 | 68 | None | -17 | 32 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | nan | |||
| DB00669 | 3707 | 68 | None | -17 | 32 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | nan | |||
| 2736460 | 207536 | 57 | None | 2 | 3 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 190 | 2 | 1 | 2 | 1.7 | CCc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
| CHEMBL9467 | 207536 | 57 | None | 2 | 3 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 190 | 2 | 1 | 2 | 1.7 | CCc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
| 59636734 | 126223 | 0 | None | - | 1 | Chinese hamster | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 396 | 5 | 0 | 5 | 3.0 | CN(C)C(=O)c1cc2cc(F)cc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| CHEMBL3650043 | 126223 | 0 | None | - | 1 | Chinese hamster | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 396 | 5 | 0 | 5 | 3.0 | CN(C)C(=O)c1cc2cc(F)cc(N3CCN(CCc4ccccn4)CC3)c2o1 | nan | |||
| 19066200 | 11381 | 0 | None | 27 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 439 | 5 | 1 | 6 | 2.8 | COc1ccc(N2CCN(C(=O)Nc3ccc(OC)c(N4CCN(C)CC4)c3)CC2)cc1 | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL108645 | 11381 | 0 | None | 27 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 439 | 5 | 1 | 6 | 2.8 | COc1ccc(N2CCN(C(=O)Nc3ccc(OC)c(N4CCN(C)CC4)c3)CC2)cc1 | 10.1016/S0960-894X(97)10164-0 | |||
| CHEMBL1179985 | 11381 | 0 | None | 27 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 439 | 5 | 1 | 6 | 2.8 | COc1ccc(N2CCN(C(=O)Nc3ccc(OC)c(N4CCN(C)CC4)c3)CC2)cc1 | 10.1016/S0960-894X(97)10164-0 | |||
| 14479835 | 208327 | 1 | None | 2 | 3 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 218 | 4 | 1 | 2 | 2.4 | CCCCc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
| CHEMBL9921 | 208327 | 1 | None | 2 | 3 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 218 | 4 | 1 | 2 | 2.4 | CCCCc1ccccc1N1CCNCC1 | 10.1021/jm00125a020 | |||
| 2176 | 3127 | 68 | None | -741 | 27 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | 10.1021/jm00384a001 | |||
| 4828 | 3127 | 68 | None | -741 | 27 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | 10.1021/jm00384a001 | |||
| 91 | 3127 | 68 | None | -741 | 27 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | 10.1021/jm00384a001 | |||
| CHEMBL500 | 3127 | 68 | None | -741 | 27 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | 10.1021/jm00384a001 | |||
| DB00960 | 3127 | 68 | None | -741 | 27 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | 10.1021/jm00384a001 | |||
| 10904295 | 4709 | 0 | None | -6 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2c[nH]c3cnc(NC(=O)c4ccc(F)cc4)cc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL103503 | 4709 | 0 | None | -6 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2c[nH]c3cnc(NC(=O)c4ccc(F)cc4)cc23)CC1 | 10.1021/jm030020m | |||
| 52899 | 97254 | 34 | None | -8 | 5 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 204 | 3 | 2 | 2 | 2.0 | COc1ccc2[nH]c(C)c(CCN)c2c1 | 10.1021/jm00164a046 | |||
| CHEMBL268800 | 97254 | 34 | None | -8 | 5 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 204 | 3 | 2 | 2 | 2.0 | COc1ccc2[nH]c(C)c(CCN)c2c1 | 10.1021/jm00164a046 | |||
| 10220230 | 107422 | 2 | None | -7 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 230 | 1 | 2 | 3 | 2.0 | CN1CCC(c2c[nH]c3ccc(N)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL318105 | 107422 | 2 | None | -7 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 230 | 1 | 2 | 3 | 2.0 | CN1CCC(c2c[nH]c3ccc(N)nc23)CC1 | 10.1021/jm030020m | |||
| 14975320 | 77245 | 0 | None | -478 | 2 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 424 | 6 | 0 | 4 | 4.1 | COc1cccc2c1[C@@H]1CCN(CCCCN3C(=O)CC4(CCCC4)CC3=O)C[C@H]1C2 | 10.1021/jm00027a013 | |||
| CHEMBL2079598 | 77245 | 0 | None | -478 | 2 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 424 | 6 | 0 | 4 | 4.1 | COc1cccc2c1[C@@H]1CCN(CCCCN3C(=O)CC4(CCCC4)CC3=O)C[C@H]1C2 | 10.1021/jm00027a013 | |||
| 2914436 | 162390 | 3 | None | -10 | 2 | Rat | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 301 | 9 | 1 | 3 | 3.7 | CCCN(CCC)CC(O)COc1cccc2ccccc12 | 10.1021/jm00124a021 | |||
| CHEMBL416564 | 162390 | 3 | None | -10 | 2 | Rat | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 301 | 9 | 1 | 3 | 3.7 | CCCN(CCC)CC(O)COc1cccc2ccccc12 | 10.1021/jm00124a021 | |||
| 11723305 | 169265 | 0 | None | -162 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 316 | 6 | 1 | 2 | 4.1 | CCCN(CCC)C1CCc2cc(F)c3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL441256 | 169265 | 0 | None | -162 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 316 | 6 | 1 | 2 | 4.1 | CCCN(CCC)C1CCc2cc(F)c3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a021 | |||
| 44376263 | 56233 | 0 | None | -13 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 448 | 6 | 2 | 3 | 4.9 | O=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2003.11.023 | |||
| CHEMBL162724 | 56233 | 0 | None | -13 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 448 | 6 | 2 | 3 | 4.9 | O=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2003.11.023 | |||
| 59636752 | 125682 | 0 | None | - | 1 | Chinese hamster | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 475 | 6 | 1 | 6 | 2.9 | CC(=O)N1CCC(NC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)CC1 | nan | |||
| CHEMBL3647264 | 125682 | 0 | None | - | 1 | Chinese hamster | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 475 | 6 | 1 | 6 | 2.9 | CC(=O)N1CCC(NC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)CC1 | nan | |||
| 49783209 | 17609 | 0 | None | -407 | 26 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 396 | 7 | 1 | 6 | 3.8 | CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | |||
| CHEMBL1258223 | 17609 | 0 | None | -407 | 26 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 396 | 7 | 1 | 6 | 3.8 | CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | |||
| 11067619 | 5135 | 0 | None | -112 | 4 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 334 | 3 | 2 | 3 | 3.6 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccc4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL105743 | 5135 | 0 | None | -112 | 4 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 334 | 3 | 2 | 3 | 3.6 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccc4)nc23)CC1 | 10.1021/jm030020m | |||
| 151 | 2416 | 44 | None | -89 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1021/jm7011722 | |||
| 20 | 2416 | 44 | None | -89 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1021/jm7011722 | |||
| 5311258 | 2416 | 44 | None | -89 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1021/jm7011722 | |||
| CHEMBL101690 | 2416 | 44 | None | -89 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1021/jm7011722 | |||
| 134138168 | 147691 | 0 | None | -75 | 10 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 275 | 4 | 0 | 2 | 4.1 | COc1ccccc1-c1cc(CN(C)C)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||
| CHEMBL3931889 | 147691 | 0 | None | -75 | 10 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 275 | 4 | 0 | 2 | 4.1 | COc1ccccc1-c1cc(CN(C)C)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||
| 213 | 3853 | 55 | None | -6 | 44 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | nan | |||
| 2717 | 3853 | 55 | None | -6 | 44 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | nan | |||
| 5533 | 3853 | 55 | None | -6 | 44 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | nan | |||
| CHEMBL621 | 3853 | 55 | None | -6 | 44 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | nan | |||
| DB00656 | 3853 | 55 | None | -6 | 44 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | nan | |||
| 76326516 | 106229 | 0 | None | 1 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 364 | 5 | 0 | 3 | 4.4 | CN1CCN([C@@H](COc2cccc(Cl)c2Cl)c2ccccc2)CC1 | 10.1007/s00044-009-9164-1 | |||
| CHEMBL2260933 | 106229 | 0 | None | 1 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 364 | 5 | 0 | 3 | 4.4 | CN1CCN([C@@H](COc2cccc(Cl)c2Cl)c2ccccc2)CC1 | 10.1007/s00044-009-9164-1 | |||
| CHEMBL3138820 | 106229 | 0 | None | 1 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 364 | 5 | 0 | 3 | 4.4 | CN1CCN([C@@H](COc2cccc(Cl)c2Cl)c2ccccc2)CC1 | 10.1007/s00044-009-9164-1 | |||
| CHEMBL5091373 | 215567 | 0 | None | -39 | 9 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | None | None | None | CNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
| CHEMBL5095981 | 215567 | 0 | None | -39 | 9 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | None | None | None | CNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
| 122483223 | 138109 | 0 | None | -11 | 7 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 455 | 8 | 0 | 5 | 5.8 | COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 | 10.1016/j.ejmech.2016.01.043 | |||
| CHEMBL3764650 | 138109 | 0 | None | -11 | 7 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 455 | 8 | 0 | 5 | 5.8 | COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 | 10.1016/j.ejmech.2016.01.043 | |||
| CHEMBL3765874 | 138109 | 0 | None | -11 | 7 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 455 | 8 | 0 | 5 | 5.8 | COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1 | 10.1016/j.ejmech.2016.01.043 | |||
| 44269068 | 98454 | 0 | None | -954 | 2 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 426 | 5 | 0 | 5 | 2.9 | COc1cccc2c1C1CCN(CCCN3C(=O)c4ccccc4S3(=O)=O)CC1C2 | 10.1021/jm00027a013 | |||
| CHEMBL275773 | 98454 | 0 | None | -954 | 2 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 426 | 5 | 0 | 5 | 2.9 | COc1cccc2c1C1CCN(CCCN3C(=O)c4ccccc4S3(=O)=O)CC1C2 | 10.1021/jm00027a013 | |||
| 2351 | 3286 | 64 | None | -10 | 21 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 473 | 7 | 2 | 6 | 6.1 | Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O | nan | |||
| 2820 | 3286 | 64 | None | -10 | 21 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 473 | 7 | 2 | 6 | 6.1 | Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O | nan | |||
| 5035 | 3286 | 64 | None | -10 | 21 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 473 | 7 | 2 | 6 | 6.1 | Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O | nan | |||
| CHEMBL81 | 3286 | 64 | None | -10 | 21 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 473 | 7 | 2 | 6 | 6.1 | Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O | nan | |||
| DB00481 | 3286 | 64 | None | -10 | 21 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 473 | 7 | 2 | 6 | 6.1 | Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O | nan | |||
| 152 | 364 | 29 | None | -57 | 18 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 10.1021/jm00164a046 | |||
| 2107 | 364 | 29 | None | -57 | 18 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 10.1021/jm00164a046 | |||
| CHEMBL275854 | 364 | 29 | None | -57 | 18 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 10.1021/jm00164a046 | |||
| 9910257 | 166672 | 0 | None | -87 | 3 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 424 | 7 | 0 | 5 | 3.6 | CC(C)Oc1ccccc1N1CCN(Cc2ccc(CN3CCCCC3=O)n2C)CC1 | 10.1021/jm00081a018 | |||
| CHEMBL428175 | 166672 | 0 | None | -87 | 3 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 424 | 7 | 0 | 5 | 3.6 | CC(C)Oc1ccccc1N1CCN(Cc2ccc(CN3CCCCC3=O)n2C)CC1 | 10.1021/jm00081a018 | |||
| 9997422 | 204276 | 0 | None | -50 | 4 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 341 | 7 | 2 | 3 | 2.8 | CCCN(CCC)[C@@H]1CCc2ccc3[nH]cc(C(=O)C(N)=O)c3c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL71247 | 204276 | 0 | None | -50 | 4 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 341 | 7 | 2 | 3 | 2.8 | CCCN(CCC)[C@@H]1CCc2ccc3[nH]cc(C(=O)C(N)=O)c3c2C1 | 10.1021/jm00012a021 | |||
| 41305446 | 167252 | 1 | None | -15 | 5 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | O=C(NCc1ccccc1)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1 | 10.1039/C8MD00204E | |||
| CHEMBL4292719 | 167252 | 1 | None | -15 | 5 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | O=C(NCc1ccccc1)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1 | 10.1039/C8MD00204E | |||
| 1212 | 1662 | 50 | None | -144 | 65 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | |||
| 204 | 1662 | 50 | None | -144 | 65 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | |||
| 3372 | 1662 | 50 | None | -144 | 65 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | |||
| CHEMBL726 | 1662 | 50 | None | -144 | 65 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | |||
| DB00623 | 1662 | 50 | None | -144 | 65 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | |||
| 122197405 | 133476 | 0 | None | -47 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 440 | 5 | 1 | 5 | 4.0 | C[C@H]1CN(c2cccc3cc(C#N)ccc23)CCN1CC[C@H]1OCc2cc(C(N)=O)ccc21 | 10.1016/j.bmcl.2007.03.101 | |||
| CHEMBL3706925 | 133476 | 0 | None | -47 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 440 | 5 | 1 | 5 | 4.0 | C[C@H]1CN(c2cccc3cc(C#N)ccc23)CCN1CC[C@H]1OCc2cc(C(N)=O)ccc21 | 10.1016/j.bmcl.2007.03.101 | |||
| 11223004 | 202214 | 0 | None | -28 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 389 | 5 | 3 | 3 | 3.9 | O=S(=O)(Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1)c1ccccc1Cl | 10.1021/jm049243i | |||
| CHEMBL609742 | 202214 | 0 | None | -28 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 389 | 5 | 3 | 3 | 3.9 | O=S(=O)(Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1)c1ccccc1Cl | 10.1021/jm049243i | |||
| 130442480 | 175270 | 0 | None | -107 | 24 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 410 | 3 | 0 | 6 | 5.7 | Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F | 10.1021/acs.jmedchem.9b00351 | |||
| CHEMBL4572614 | 175270 | 0 | None | -107 | 24 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 410 | 3 | 0 | 6 | 5.7 | Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F | 10.1021/acs.jmedchem.9b00351 | |||
| 44582675 | 189701 | 0 | None | -15 | 15 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 405 | 9 | 1 | 4 | 4.2 | COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | |||
| CHEMBL515472 | 189701 | 0 | None | -15 | 15 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 405 | 9 | 1 | 4 | 4.2 | COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | |||
| 9907305 | 30194 | 0 | None | -1513 | 2 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 368 | 5 | 1 | 3 | 3.2 | COc1cccc2c1C1CCN(CCNC(=O)c3ccc(F)cc3)CC1C2 | 10.1021/jm00027a013 | |||
| CHEMBL13904 | 30194 | 0 | None | -1513 | 2 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 368 | 5 | 1 | 3 | 3.2 | COc1cccc2c1C1CCN(CCNC(=O)c3ccc(F)cc3)CC1C2 | 10.1021/jm00027a013 | |||
| 90469115 | 185842 | 4 | None | -295 | 17 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 410 | 3 | 1 | 6 | 3.0 | O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21 | 10.1021/acs.jmedchem.1c00224 | |||
| CHEMBL4867565 | 185842 | 4 | None | -295 | 17 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 410 | 3 | 1 | 6 | 3.0 | O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21 | 10.1021/acs.jmedchem.1c00224 | |||
| 64622 | 96854 | 6 | None | -2238 | 5 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 425 | 8 | 1 | 4 | 3.9 | COc1ccccc1N1CCN(CCCCNC(=O)C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)CC1 | 10.1021/jm00112a043 | |||
| CHEMBL26533 | 96854 | 6 | None | -2238 | 5 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 425 | 8 | 1 | 4 | 3.9 | COc1ccccc1N1CCN(CCCCNC(=O)C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)CC1 | 10.1021/jm00112a043 | |||
| 127036932 | 137348 | 0 | None | -29 | 22 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 274 | 7 | 1 | 1 | 4.0 | C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12 | 10.1016/j.bmcl.2015.12.053 | |||
| CHEMBL3752900 | 137348 | 0 | None | -29 | 22 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 274 | 7 | 1 | 1 | 4.0 | C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12 | 10.1016/j.bmcl.2015.12.053 | |||
| 59636704 | 125683 | 0 | None | - | 1 | Chinese hamster | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 455 | 7 | 1 | 6 | 4.1 | CC(NC(=O)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1)c1ccccn1 | nan | |||
| CHEMBL3647265 | 125683 | 0 | None | - | 1 | Chinese hamster | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 455 | 7 | 1 | 6 | 4.1 | CC(NC(=O)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1)c1ccccn1 | nan | |||
| 2543 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm7011722 | |||
| 5358 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm7011722 | |||
| 54 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm7011722 | |||
| CHEMBL128 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm7011722 | |||
| DB00669 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm7011722 | |||
| 59636741 | 125698 | 0 | None | - | 1 | Chinese hamster | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 465 | 7 | 1 | 6 | 4.0 | N#Cc1cccc(CNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)c1 | nan | |||
| CHEMBL3647280 | 125698 | 0 | None | - | 1 | Chinese hamster | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 465 | 7 | 1 | 6 | 4.0 | N#Cc1cccc(CNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)c1 | nan | |||
| 150 | 2509 | 21 | None | -6 | 16 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | nan | |||
| 1764 | 2509 | 21 | None | -6 | 16 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | nan | |||
| 8226 | 2509 | 21 | None | -6 | 16 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | nan | |||
| CHEMBL1201356 | 2509 | 21 | None | -6 | 16 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | nan | |||
| DB00353 | 2509 | 21 | None | -6 | 16 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | nan | |||
| 46232642 | 200834 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 457 | 4 | 3 | 5 | 3.9 | Cc1n[nH]c(C)c1-c1ccc(C)c2c(=O)cc(C(=O)Nc3ccc(N4CCOCC4)cc3)[nH]c12 | 10.1021/jm901200t | |||
| CHEMBL601012 | 200834 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 457 | 4 | 3 | 5 | 3.9 | Cc1n[nH]c(C)c1-c1ccc(C)c2c(=O)cc(C(=O)Nc3ccc(N4CCOCC4)cc3)[nH]c12 | 10.1021/jm901200t | |||
| 23533306 | 85181 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 465 | 4 | 2 | 6 | 2.5 | CN1CCN(c2cc(F)cc3c(=O)cc(C(=O)Nc4ccc(N5CCOCC5)cc4)[nH]c23)CC1 | 10.1016/j.bmc.2006.10.037 | |||
| CHEMBL225363 | 85181 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 465 | 4 | 2 | 6 | 2.5 | CN1CCN(c2cc(F)cc3c(=O)cc(C(=O)Nc4ccc(N5CCOCC5)cc4)[nH]c23)CC1 | 10.1016/j.bmc.2006.10.037 | |||
| 71459954 | 79182 | 0 | None | -9 | 7 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 495 | 6 | 3 | 3 | 4.0 | O=S(=O)(Cc1ccccc1I)Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1 | 10.1021/jm049243i | |||
| CHEMBL2113386 | 79182 | 0 | None | -9 | 7 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 495 | 6 | 3 | 3 | 4.0 | O=S(=O)(Cc1ccccc1I)Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1 | 10.1021/jm049243i | |||
| 46232642 | 200834 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 457 | 4 | 3 | 5 | 3.9 | Cc1n[nH]c(C)c1-c1ccc(C)c2c(=O)cc(C(=O)Nc3ccc(N4CCOCC4)cc3)[nH]c12 | 10.1021/jm901200t | |||
| CHEMBL601012 | 200834 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 457 | 4 | 3 | 5 | 3.9 | Cc1n[nH]c(C)c1-c1ccc(C)c2c(=O)cc(C(=O)Nc3ccc(N4CCOCC4)cc3)[nH]c12 | 10.1021/jm901200t | |||
| 2543 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9805945 | |||
| 5358 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9805945 | |||
| 54 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9805945 | |||
| CHEMBL128 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9805945 | |||
| DB00669 | 3707 | 68 | None | -3 | 32 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9805945 | |||
| 44403106 | 71415 | 0 | None | 1 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 438 | 6 | 1 | 6 | 3.3 | COc1ccccc1N1CCC(C(=O)Nc2ccc(OC)c(N3CCN(C)CC3)c2)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
| CHEMBL195927 | 71415 | 0 | None | 1 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 438 | 6 | 1 | 6 | 3.3 | COc1ccccc1N1CCC(C(=O)Nc2ccc(OC)c(N3CCN(C)CC3)c2)CC1 | 10.1016/j.bmcl.2005.07.024 | |||
| 44383737 | 132521 | 0 | None | -5 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 340 | 6 | 1 | 3 | 4.6 | COC[C@@H]1CCCN1CCc1c[nH]c2ccc(-c3cccs3)cc12 | 10.1016/s0960-894x(00)00133-5 | |||
| CHEMBL369798 | 132521 | 0 | None | -5 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 340 | 6 | 1 | 3 | 4.6 | COC[C@@H]1CCCN1CCc1c[nH]c2ccc(-c3cccs3)cc12 | 10.1016/s0960-894x(00)00133-5 | |||
| 145 | 140 | 49 | None | -47 | 30 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00384a001 | |||
| 1832 | 140 | 49 | None | -47 | 30 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00384a001 | |||
| CHEMBL7257 | 140 | 49 | None | -47 | 30 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00384a001 | |||
| DB14010 | 140 | 49 | None | -47 | 30 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm00384a001 | |||
| 14519863 | 115201 | 1 | None | -58 | 3 | Rat | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 299 | 10 | 0 | 2 | 5.1 | CCCCN(CCCC)CCOc1cccc2ccccc12 | 10.1021/jm00124a021 | |||
| CHEMBL334465 | 115201 | 1 | None | -58 | 3 | Rat | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 299 | 10 | 0 | 2 | 5.1 | CCCCN(CCCC)CCOc1cccc2ccccc12 | 10.1021/jm00124a021 | |||
| 10197933 | 97033 | 39 | None | -7 | 2 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 177 | 1 | 1 | 2 | 1.5 | COc1cccc2c1CC(N)CC2 | 10.1016/S0960-894X(01)81009-X | |||
| CHEMBL26688 | 97033 | 39 | None | -7 | 2 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 177 | 1 | 1 | 2 | 1.5 | COc1cccc2c1CC(N)CC2 | 10.1016/S0960-894X(01)81009-X | |||
| 44431533 | 88026 | 0 | None | -1 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 447 | 5 | 1 | 4 | 4.3 | C[C@@H]1CN(c2cccc3cc(F)ccc23)CCN1CC[C@H]1OCCc2cc(C(N)=O)ccc21 | 10.1016/j.bmcl.2007.03.101 | |||
| CHEMBL234448 | 88026 | 0 | None | -1 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 447 | 5 | 1 | 4 | 4.3 | C[C@@H]1CN(c2cccc3cc(F)ccc23)CCN1CC[C@H]1OCCc2cc(C(N)=O)ccc21 | 10.1016/j.bmcl.2007.03.101 | |||
| 10257 | 738 | 31 | None | -141 | 19 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 204 | 3 | 2 | 2 | 2.0 | CN(CCc1c[nH]c2c1cc(O)cc2)C | 10.1021/jm00384a001 | |||
| 144 | 738 | 31 | None | -141 | 19 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 204 | 3 | 2 | 2 | 2.0 | CN(CCc1c[nH]c2c1cc(O)cc2)C | 10.1021/jm00384a001 | |||
| CHEMBL416526 | 738 | 31 | None | -141 | 19 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 204 | 3 | 2 | 2 | 2.0 | CN(CCc1c[nH]c2c1cc(O)cc2)C | 10.1021/jm00384a001 | |||
| DB01445 | 738 | 31 | None | -141 | 19 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 204 | 3 | 2 | 2 | 2.0 | CN(CCc1c[nH]c2c1cc(O)cc2)C | 10.1021/jm00384a001 | |||
| 11747350 | 107332 | 0 | None | -45 | 10 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 260 | 5 | 1 | 3 | 2.4 | CCOC(=O)c1[nH]c2ccccc2c1CCN(C)C | 10.1021/jm010943m | |||
| CHEMBL317535 | 107332 | 0 | None | -45 | 10 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 260 | 5 | 1 | 3 | 2.4 | CCOC(=O)c1[nH]c2ccccc2c1CCN(C)C | 10.1021/jm010943m | |||
| 76312090 | 106249 | 0 | None | 6 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 364 | 5 | 0 | 3 | 4.4 | CN1CCN([C@H](COc2cccc(Cl)c2Cl)c2ccccc2)CC1 | 10.1007/s00044-009-9164-1 | |||
| CHEMBL2260934 | 106249 | 0 | None | 6 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 364 | 5 | 0 | 3 | 4.4 | CN1CCN([C@H](COc2cccc(Cl)c2Cl)c2ccccc2)CC1 | 10.1007/s00044-009-9164-1 | |||
| CHEMBL3138934 | 106249 | 0 | None | 6 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 364 | 5 | 0 | 3 | 4.4 | CN1CCN([C@H](COc2cccc(Cl)c2Cl)c2ccccc2)CC1 | 10.1007/s00044-009-9164-1 | |||
| 9996017 | 21246 | 0 | None | -114 | 2 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 318 | 3 | 0 | 3 | 3.9 | c1ccc2c(c1)CC2CN1CCN(c2cccc3ccoc23)CC1 | 10.1021/jm00020a020 | |||
| CHEMBL131324 | 21246 | 0 | None | -114 | 2 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 318 | 3 | 0 | 3 | 3.9 | c1ccc2c(c1)CC2CN1CCN(c2cccc3ccoc23)CC1 | 10.1021/jm00020a020 | |||
| 6918542 | 204924 | 24 | None | -2238 | 10 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 358 | 6 | 0 | 5 | 3.0 | COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1 | 10.1016/s0960-894x(00)00453-4 | |||
| CHEMBL76237 | 204924 | 24 | None | -2238 | 10 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 358 | 6 | 0 | 5 | 3.0 | COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1 | 10.1016/s0960-894x(00)00453-4 | |||
| 11120893 | 4522 | 0 | None | -204 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 324 | 3 | 2 | 4 | 3.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccoc4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL102250 | 4522 | 0 | None | -204 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 324 | 3 | 2 | 4 | 3.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccoc4)nc23)CC1 | 10.1021/jm030020m | |||
| 75201901 | 166425 | 19 | None | -691 | 24 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 356 | 3 | 0 | 6 | 4.9 | Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12 | 10.1021/acs.jmedchem.9b00351 | |||
| CHEMBL4277264 | 166425 | 19 | None | -691 | 24 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 356 | 3 | 0 | 6 | 4.9 | Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12 | 10.1021/acs.jmedchem.9b00351 | |||
| 130442572 | 171908 | 0 | None | -199 | 24 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 395 | 3 | 0 | 5 | 6.0 | FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12 | 10.1021/acs.jmedchem.9b00351 | |||
| CHEMBL4469848 | 171908 | 0 | None | -199 | 24 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 395 | 3 | 0 | 5 | 6.0 | FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12 | 10.1021/acs.jmedchem.9b00351 | |||
| 10361292 | 116656 | 0 | None | -1737 | 2 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 362 | 4 | 0 | 4 | 3.6 | C1=C(CCN2CCN(c3cccc4c3OCCO4)CC2)Cc2ccccc21 | 10.1021/jm00020a020 | |||
| CHEMBL337036 | 116656 | 0 | None | -1737 | 2 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 362 | 4 | 0 | 4 | 3.6 | C1=C(CCN2CCN(c3cccc4c3OCCO4)CC2)Cc2ccccc21 | 10.1021/jm00020a020 | |||
| 4189 | 206922 | 96 | None | -41 | 34 | Rat | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | |||
| CHEMBL1559 | 206922 | 96 | None | -41 | 34 | Rat | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | |||
| CHEMBL91 | 206922 | 96 | None | -41 | 34 | Rat | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | |||
| 9948210 | 103121 | 1 | None | -1479 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 298 | 6 | 1 | 2 | 4.0 | CCCN(CCC)[C@H]1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL307786 | 103121 | 1 | None | -1479 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 298 | 6 | 1 | 2 | 4.0 | CCCN(CCC)[C@H]1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL4777443 | 214046 | 0 | None | -45 | 14 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | None | None | None | CC(C)(C)OC(=O)N1CCCC1CN[C@H]1CC[C@@](c2cc(F)ccc2F)(S(=O)(=O)c2ccc(Cl)cc2)CC1 | 10.6019/CHEMBL5212743 | |||||
| 10401862 | 102671 | 1 | None | -257 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 288 | 5 | 1 | 1 | 4.3 | CCCN(CCC)[C@H]1CCc2cc(F)c3[nH]ccc3c2C1 | 10.1021/jm00012a021 | |||
| CHEMBL304573 | 102671 | 1 | None | -257 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 288 | 5 | 1 | 1 | 4.3 | CCCN(CCC)[C@H]1CCc2cc(F)c3[nH]ccc3c2C1 | 10.1021/jm00012a021 | |||
| 44376363 | 55352 | 0 | None | -6 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 480 | 6 | 2 | 3 | 5.9 | S=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2003.11.023 | |||
| CHEMBL161894 | 55352 | 0 | None | -6 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 480 | 6 | 2 | 3 | 5.9 | S=C(NN1CC=C(c2ccc3[nH]cc(CCN4CCCC4)c3c2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2003.11.023 | |||
| 15724503 | 46197 | 0 | None | -2 | 3 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 400 | 5 | 0 | 4 | 3.5 | Cn1c(CN2CCN(c3cccc(Cl)c3)CC2)ccc1CN1CCCCC1=O | 10.1021/jm00081a018 | |||
| CHEMBL153451 | 46197 | 0 | None | -2 | 3 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 400 | 5 | 0 | 4 | 3.5 | Cn1c(CN2CCN(c3cccc(Cl)c3)CC2)ccc1CN1CCCCC1=O | 10.1021/jm00081a018 | |||
| 127036953 | 137515 | 0 | None | -95 | 22 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 318 | 7 | 1 | 1 | 4.1 | C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12 | 10.1016/j.bmcl.2015.12.053 | |||
| CHEMBL3754166 | 137515 | 0 | None | -95 | 22 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 318 | 7 | 1 | 1 | 4.1 | C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12 | 10.1016/j.bmcl.2015.12.053 | |||
| 71452384 | 83797 | 0 | None | -4 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 280 | 3 | 1 | 3 | 1.4 | OC12C3C4CC5C6C4C1C6C(C53)N2CCc1ccccn1 | 10.1016/j.bmcl.2012.08.046 | |||
| CHEMBL2205816 | 83797 | 0 | None | -4 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 280 | 3 | 1 | 3 | 1.4 | OC12C3C4CC5C6C4C1C6C(C53)N2CCc1ccccn1 | 10.1016/j.bmcl.2012.08.046 | |||
| 71452384 | 83797 | 0 | None | -4 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 280 | 3 | 1 | 3 | 1.4 | OC12C3C4CC5C6C4C1C6C(C53)N2CCc1ccccn1 | 10.1016/j.bmc.2013.07.045 | |||
| CHEMBL2205816 | 83797 | 0 | None | -4 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 280 | 3 | 1 | 3 | 1.4 | OC12C3C4CC5C6C4C1C6C(C53)N2CCc1ccccn1 | 10.1016/j.bmc.2013.07.045 | |||
| 135398737 | 958 | 93 | None | -691 | 89 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | |||
| 38 | 958 | 93 | None | -691 | 89 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | |||
| 722 | 958 | 93 | None | -691 | 89 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | |||
| CHEMBL42 | 958 | 93 | None | -691 | 89 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | |||
| DB00363 | 958 | 93 | None | -691 | 89 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | |||
| 44461248 | 205359 | 0 | None | -3 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 407 | 5 | 2 | 3 | 3.9 | NC(=O)c1ccc2c(c1)CCOC2CCN1CCC(c2c[nH]c3cc(F)ccc23)C1 | 10.1016/j.bmcl.2004.03.003 | |||
| CHEMBL79725 | 205359 | 0 | None | -3 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 407 | 5 | 2 | 3 | 3.9 | NC(=O)c1ccc2c(c1)CCOC2CCN1CCC(c2c[nH]c3cc(F)ccc23)C1 | 10.1016/j.bmcl.2004.03.003 | |||
| 14975317 | 77235 | 0 | None | -138 | 2 | Rat | 4.0 | pKi | = | 4.0 | Binding | ChEMBL | 410 | 5 | 0 | 4 | 3.8 | COc1cccc2c1[C@@H]1CCN(CCCN3C(=O)CC4(CCCC4)CC3=O)C[C@@H]1C2 | 10.1021/jm00027a013 | |||
| CHEMBL2079546 | 77235 | 0 | None | -138 | 2 | Rat | 4.0 | pKi | = | 4.0 | Binding | ChEMBL | 410 | 5 | 0 | 4 | 3.8 | COc1cccc2c1[C@@H]1CCN(CCCN3C(=O)CC4(CCCC4)CC3=O)C[C@@H]1C2 | 10.1021/jm00027a013 | |||
| 118464425 | 138309 | 0 | None | -257 | 9 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 357 | 3 | 2 | 7 | 2.8 | CCOC(=O)c1cccc(NC2=NC(N(C)C)=NC3(CCCCC3)N2)c1 | 10.1021/acs.jmedchem.5b01631 | |||
| CHEMBL3770981 | 138309 | 0 | None | -257 | 9 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 357 | 3 | 2 | 7 | 2.8 | CCOC(=O)c1cccc(NC2=NC(N(C)C)=NC3(CCCCC3)N2)c1 | 10.1021/acs.jmedchem.5b01631 | |||
| 146025727 | 171685 | 0 | None | -371 | 27 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 411 | 3 | 0 | 5 | 6.4 | FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12 | 10.1021/acs.jmedchem.9b00351 | |||
| CHEMBL4466483 | 171685 | 0 | None | -371 | 27 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 411 | 3 | 0 | 5 | 6.4 | FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12 | 10.1021/acs.jmedchem.9b00351 | |||
| 10383010 | 163499 | 0 | None | -371 | 5 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 346 | 6 | 1 | 2 | 4.8 | CCCN(Cc1ccccc1)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| CHEMBL420191 | 163499 | 0 | None | -371 | 5 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 346 | 6 | 1 | 2 | 4.8 | CCCN(Cc1ccccc1)C1CCc2ccc3[nH]cc(C=O)c3c2C1 | 10.1021/jm00012a022 | |||
| 1524 | 2181 | 96 | None | -2511 | 52 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 197 | 2181 | 96 | None | -2511 | 52 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 3822 | 2181 | 96 | None | -2511 | 52 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 88 | 2181 | 96 | None | -2511 | 52 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| CHEMBL51 | 2181 | 96 | None | -2511 | 52 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| DB12465 | 2181 | 96 | None | -2511 | 52 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 135398737 | 958 | 93 | None | -691 | 89 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 38 | 958 | 93 | None | -691 | 89 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 722 | 958 | 93 | None | -691 | 89 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| CHEMBL42 | 958 | 93 | None | -691 | 89 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| DB00363 | 958 | 93 | None | -691 | 89 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 123606 | 352 | 70 | None | -1 | 3 | Human | 7.9 | pIC50 | = | 7.9 | Binding | Guide to Pharmacology | 335 | 6 | 1 | 3 | 2.2 | CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C | 11134654 | |||
| 128 | 352 | 70 | None | -1 | 3 | Human | 7.9 | pIC50 | = | 7.9 | Binding | Guide to Pharmacology | 335 | 6 | 1 | 3 | 2.2 | CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C | 11134654 | |||
| 7110 | 352 | 70 | None | -1 | 3 | Human | 7.9 | pIC50 | = | 7.9 | Binding | Guide to Pharmacology | 335 | 6 | 1 | 3 | 2.2 | CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C | 11134654 | |||
| CHEMBL1505 | 352 | 70 | None | -1 | 3 | Human | 7.9 | pIC50 | = | 7.9 | Binding | Guide to Pharmacology | 335 | 6 | 1 | 3 | 2.2 | CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C | 11134654 | |||
| DB00918 | 352 | 70 | None | -1 | 3 | Human | 7.9 | pIC50 | = | 7.9 | Binding | Guide to Pharmacology | 335 | 6 | 1 | 3 | 2.2 | CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C | 11134654 | |||
| 40 | 1547 | 58 | None | -2 | 5 | Human | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | None | |||
| 77993 | 1547 | 58 | None | -2 | 5 | Human | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | None | |||
| 995 | 1547 | 58 | None | -2 | 5 | Human | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | None | |||
| CHEMBL1510 | 1547 | 58 | None | -2 | 5 | Human | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | None | |||
| DB00216 | 1547 | 58 | None | -2 | 5 | Human | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | None | |||
| 5 | 139 | 72 | None | -11 | 54 | Human | 8.0 | pKd | = | 8.0 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 1565658 | |||
| 5 | 139 | 72 | None | -11 | 54 | Human | 8.0 | pKd | = | 8.0 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8863519 | |||
| 5202 | 139 | 72 | None | -11 | 54 | Human | 8.0 | pKd | = | 8.0 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 1565658 | |||
| 5202 | 139 | 72 | None | -11 | 54 | Human | 8.0 | pKd | = | 8.0 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8863519 | |||
| CHEMBL39 | 139 | 72 | None | -11 | 54 | Human | 8.0 | pKd | = | 8.0 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 1565658 | |||
| CHEMBL39 | 139 | 72 | None | -11 | 54 | Human | 8.0 | pKd | = | 8.0 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8863519 | |||
| DB08839 | 139 | 72 | None | -11 | 54 | Human | 8.0 | pKd | = | 8.0 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 1565658 | |||
| DB08839 | 139 | 72 | None | -11 | 54 | Human | 8.0 | pKd | = | 8.0 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8863519 | |||
| 117 | 353 | 19 | None | -1 | 2 | Human | 8.8 | pKd | = | 8.8 | Binding | Guide to Pharmacology | 302 | 6 | 3 | 5 | 1.3 | C(NC[C@H]1CCc2c(O1)cccc2)CCNC1=NCCCN1 | 9605573 | |||
| 120 | 353 | 19 | None | -1 | 2 | Human | 8.8 | pKd | = | 8.8 | Binding | Guide to Pharmacology | 302 | 6 | 3 | 5 | 1.3 | C(NC[C@H]1CCc2c(O1)cccc2)CCNC1=NCCCN1 | 9605573 | |||
| 66004 | 353 | 19 | None | -1 | 2 | Human | 8.8 | pKd | = | 8.8 | Binding | Guide to Pharmacology | 302 | 6 | 3 | 5 | 1.3 | C(NC[C@H]1CCc2c(O1)cccc2)CCNC1=NCCCN1 | 9605573 | |||
| CHEMBL88240 | 353 | 19 | None | -1 | 2 | Human | 8.8 | pKd | = | 8.8 | Binding | Guide to Pharmacology | 302 | 6 | 3 | 5 | 1.3 | C(NC[C@H]1CCc2c(O1)cccc2)CCNC1=NCCCN1 | 9605573 | |||
| 1220 | 187 | 55 | None | -208 | 44 | Human | 8.9 | pKd | = | 8.9 | Binding | Guide to Pharmacology | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10431754 | |||
| 31 | 187 | 55 | None | -208 | 44 | Human | 8.9 | pKd | = | 8.9 | Binding | Guide to Pharmacology | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10431754 | |||
| 7 | 187 | 55 | None | -208 | 44 | Human | 8.9 | pKd | = | 8.9 | Binding | Guide to Pharmacology | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10431754 | |||
| CHEMBL56 | 187 | 55 | None | -208 | 44 | Human | 8.9 | pKd | = | 8.9 | Binding | Guide to Pharmacology | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 10431754 | |||
| None | 215938 | 0 | 3H-5HT | -3 | 21 | Human | 11.2 | pKi | = | 11.2 | Binding | PDSP KiDatabase | 583 | 4 | 3 | 6 | 2.1 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C | None | |||
| None | 215938 | 0 | 3H-5HT | -3 | 21 | Human | 11.2 | pKi | = | 11.2 | Binding | PDSP KiDatabase | 583 | 4 | 3 | 6 | 2.1 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C | None | |||
| None | 215938 | 0 | 3H-5HT | -18 | 21 | Rat | 10.7 | pKi | = | 10.7 | Binding | PDSP KiDatabase | 583 | 4 | 3 | 6 | 2.1 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C | None | |||
| 11954224 | 215953 | 0 | 3H-5HT | -12 | 58 | Rat | 10.5 | pKi | = | 10.5 | Binding | PDSP KiDatabase | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
| 71299720 | 215951 | 0 | 3H-5HT | 1 | 17 | Human | 10.4 | pKi | = | 10.4 | Binding | PDSP KiDatabase | 450 | 3 | 2 | 6 | 3.0 | CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4.C(=CC(=O)O)C(=O)O | None | |||
| 11797998 | 35692 | 0 | UNDEFINED | 1 | 3 | Human | 10.0 | pKi | = | 10 | Binding | PDSP KiDatabase | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3ccc(COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12 | None | |||
| CHEMBL144030 | 35692 | 0 | UNDEFINED | 1 | 3 | Human | 10.0 | pKi | = | 10 | Binding | PDSP KiDatabase | 454 | 10 | 4 | 4 | 4.8 | NCCc1c[nH]c2ccc(OCc3ccc(COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12 | None | |||
| 24881753 | 137202 | 0 | UNDEFINED | 14 | 2 | Human | 10.0 | pKi | = | 10 | Binding | PDSP KiDatabase | 666 | 16 | 4 | 4 | 9.1 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | None | |||
| CHEMBL374973 | 137202 | 0 | UNDEFINED | 14 | 2 | Human | 10.0 | pKi | = | 10 | Binding | PDSP KiDatabase | 666 | 16 | 4 | 4 | 9.1 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | None | |||
| 1809 | 134 | 32 | 3H-5HT | -15 | 36 | Human | 9.9 | pKi | = | 9.9 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-5HT | -15 | 36 | Human | 9.9 | pKi | = | 9.9 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-5HT | -15 | 36 | Human | 9.9 | pKi | = | 9.9 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 107780 | 1844 | 54 | 3H-5HT | 1 | 17 | Human | 9.9 | pKi | = | 9.9 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 14 | 1844 | 54 | 3H-5HT | 1 | 17 | Human | 9.9 | pKi | = | 9.9 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| CHEMBL15928 | 1844 | 54 | 3H-5HT | 1 | 17 | Human | 9.9 | pKi | = | 9.9 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 1809 | 134 | 32 | 3H-5HT | -15 | 36 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-5HT | -15 | 36 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-5HT | -15 | 36 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4106 | 2502 | 22 | 3H-5HT | -11 | 34 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 5358812 | 2502 | 22 | 3H-5HT | -11 | 34 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 89 | 2502 | 22 | 3H-5HT | -11 | 34 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| CHEMBL93240 | 2502 | 22 | 3H-5HT | -11 | 34 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 4106 | 2502 | 22 | 3H-5HT | -11 | 34 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 5358812 | 2502 | 22 | 3H-5HT | -11 | 34 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 89 | 2502 | 22 | 3H-5HT | -11 | 34 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| CHEMBL93240 | 2502 | 22 | 3H-5HT | -11 | 34 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 1809 | 134 | 32 | 3H-5HT | -15 | 36 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-5HT | -15 | 36 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-5HT | -15 | 36 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 132 | 1275 | 13 | 3H-5HT | -54 | 15 | Rat | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| 155346 | 1275 | 13 | 3H-5HT | -54 | 15 | Rat | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| CHEMBL378501 | 1275 | 13 | 3H-5HT | -54 | 15 | Rat | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| 124 | 2981 | 47 | 3H-5HT | 1 | 33 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| 2032 | 2981 | 47 | 3H-5HT | 1 | 33 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| 4636 | 2981 | 47 | 3H-5HT | 1 | 33 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| CHEMBL762 | 2981 | 47 | 3H-5HT | 1 | 33 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| DB00935 | 2981 | 47 | 3H-5HT | 1 | 33 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| 132 | 1275 | 13 | 3H-5HT | -54 | 15 | Rat | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| 155346 | 1275 | 13 | 3H-5HT | -54 | 15 | Rat | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| CHEMBL378501 | 1275 | 13 | 3H-5HT | -54 | 15 | Rat | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| 11954224 | 215953 | 0 | 3H-GR125743 | -32 | 58 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
| None | 215946 | 0 | 3H-GR-125743 | 2 | 24 | Rat | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 346 | 5 | 4 | 4 | 2.5 | COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O | None | |||
| 1809 | 134 | 32 | 3H-GR-125743 | -32 | 36 | Rat | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-GR-125743 | -32 | 36 | Rat | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-GR-125743 | -32 | 36 | Rat | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 1809 | 134 | 32 | 3H-5HT | -32 | 36 | Rat | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-5HT | -32 | 36 | Rat | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-5HT | -32 | 36 | Rat | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| None | 215946 | 0 | 3H-5HT | 2 | 24 | Rat | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 346 | 5 | 4 | 4 | 2.5 | COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O | None | |||
| None | 215946 | 0 | 3H-5HT | 2 | 24 | Rat | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 346 | 5 | 4 | 4 | 2.5 | COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O | None | |||
| 152662 | 215957 | 0 | 3H-5HT | 109 | 7 | Rat | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 276 | 5 | 3 | 3 | 2.6 | CC1=CC2=C(N1)C=CC=C2OCC(CNC(C)(C)C)O | None | |||
| 107780 | 1844 | 54 | 3H-GR-125743 | 1 | 17 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 14 | 1844 | 54 | 3H-GR-125743 | 1 | 17 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| CHEMBL15928 | 1844 | 54 | 3H-GR-125743 | 1 | 17 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 152662 | 215957 | 0 | 125I-CYP | 109 | 7 | Rat | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 276 | 5 | 3 | 3 | 2.6 | CC1=CC2=C(N1)C=CC=C2OCC(CNC(C)(C)C)O | None | |||
| 24881204 | 188422 | 0 | UNDEFINED | 3 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 680 | 17 | 4 | 4 | 9.5 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | None | |||
| CHEMBL502138 | 188422 | 0 | UNDEFINED | 3 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 680 | 17 | 4 | 4 | 9.5 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | None | |||
| None | 215938 | 0 | 3H-5HT | -3 | 21 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 583 | 4 | 3 | 6 | 2.1 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C | None | |||
| 5 | 139 | 72 | 3H-5HT | -11 | 54 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-5HT | -11 | 54 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-5HT | -11 | 54 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-5HT | -11 | 54 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 24881754 | 188292 | 0 | UNDEFINED | 3 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 694 | 18 | 4 | 4 | 9.9 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | None | |||
| CHEMBL500284 | 188292 | 0 | UNDEFINED | 3 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 694 | 18 | 4 | 4 | 9.9 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | None | |||
| 5 | 139 | 72 | 3H-5HT | -11 | 54 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-5HT | -11 | 54 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-5HT | -11 | 54 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-5HT | -11 | 54 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 12312583 | 216017 | 0 | 3H-5HT | 1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 254 | 1 | 2 | 2 | 2.0 | CN1CC(C=C2C1CC3=CNC4=CC=CC2=C34)CO | None | |||
| 9832057 | 52315 | 0 | UNDEFINED | 1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 692 | 16 | 2 | 6 | 4.8 | CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N(C)Cc3ccc(CN(C)S(=O)(=O)Cc4ccc5[nH]cc(CCN(C)C)c5c4)cc3)cc12 | None | |||
| CHEMBL158941 | 52315 | 0 | UNDEFINED | 1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 692 | 16 | 2 | 6 | 4.8 | CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N(C)Cc3ccc(CN(C)S(=O)(=O)Cc4ccc5[nH]cc(CCN(C)C)c5c4)cc3)cc12 | None | |||
| 1809 | 134 | 32 | 3H-5HT | -15 | 36 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-5HT | -15 | 36 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-5HT | -15 | 36 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| None | 215938 | 0 | 125I-CYP | -18 | 21 | Rat | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 583 | 4 | 3 | 6 | 2.1 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C | None | |||
| 107 | 141 | 121 | 3H-5HT | -16 | 30 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1833 | 141 | 121 | 3H-5HT | -16 | 30 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| CHEMBL8165 | 141 | 121 | 3H-5HT | -16 | 30 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 44279525 | 105512 | 0 | UNDEFINED | -1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 444 | 8 | 2 | 5 | 4.0 | CN1CCN(c2cccc3ccc(OCCOc4ccc5[nH]cc(CCN)c5c4)cc23)CC1 | None | |||
| CHEMBL31217 | 105512 | 0 | UNDEFINED | -1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 444 | 8 | 2 | 5 | 4.0 | CN1CCN(c2cccc3ccc(OCCOc4ccc5[nH]cc(CCN)c5c4)cc23)CC1 | None | |||
| 24881689 | 170132 | 0 | UNDEFINED | 1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 554 | 8 | 4 | 4 | 6.0 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | None | |||
| CHEMBL444404 | 170132 | 0 | UNDEFINED | 1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 554 | 8 | 4 | 4 | 6.0 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | None | |||
| 1809 | 134 | 32 | 3H-GR-125743 | -8 | 36 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-GR-125743 | -8 | 36 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-GR-125743 | -8 | 36 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 24881203 | 173231 | 0 | UNDEFINED | 1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 624 | 13 | 4 | 4 | 8.0 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | None | |||
| CHEMBL452387 | 173231 | 0 | UNDEFINED | 1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 624 | 13 | 4 | 4 | 8.0 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | None | |||
| 124 | 2981 | 47 | 3H-5HT | -2 | 33 | Rat | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| 2032 | 2981 | 47 | 3H-5HT | -2 | 33 | Rat | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| 4636 | 2981 | 47 | 3H-5HT | -2 | 33 | Rat | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| CHEMBL762 | 2981 | 47 | 3H-5HT | -2 | 33 | Rat | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| DB00935 | 2981 | 47 | 3H-5HT | -2 | 33 | Rat | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| 24881264 | 188307 | 0 | UNDEFINED | 13 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 709 | 19 | 4 | 4 | 10.3 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | None | |||
| CHEMBL500488 | 188307 | 0 | UNDEFINED | 13 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 709 | 19 | 4 | 4 | 10.3 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | None | |||
| 124 | 2981 | 47 | 3H-5HT | -2 | 33 | Rat | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| 2032 | 2981 | 47 | 3H-5HT | -2 | 33 | Rat | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| 4636 | 2981 | 47 | 3H-5HT | -2 | 33 | Rat | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| CHEMBL762 | 2981 | 47 | 3H-5HT | -2 | 33 | Rat | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| DB00935 | 2981 | 47 | 3H-5HT | -2 | 33 | Rat | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| 5 | 139 | 72 | 3H-GR-125743 | -13 | 54 | Rat | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-GR-125743 | -13 | 54 | Rat | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-GR-125743 | -13 | 54 | Rat | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-GR-125743 | -13 | 54 | Rat | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 1809 | 134 | 32 | 3H-5HT | -15 | 36 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-5HT | -15 | 36 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-5HT | -15 | 36 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 133 | 2496 | 52 | 3H-5HT | -40 | 42 | Rat | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 1723 | 2496 | 52 | 3H-5HT | -40 | 42 | Rat | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 28693 | 2496 | 52 | 3H-5HT | -40 | 42 | Rat | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| CHEMBL19215 | 2496 | 52 | 3H-5HT | -40 | 42 | Rat | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| DB13520 | 2496 | 52 | 3H-5HT | -40 | 42 | Rat | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| None | 215946 | 0 | 3H-5HT | 2 | 24 | Rat | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 346 | 5 | 4 | 4 | 2.5 | COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O | None | |||
| 107780 | 1844 | 54 | 35S-GTPGammaS | 1 | 17 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 14 | 1844 | 54 | 35S-GTPGammaS | 1 | 17 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| CHEMBL15928 | 1844 | 54 | 35S-GTPGammaS | 1 | 17 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 2865 | 4143 | 73 | 3H-Alniditan | -12 | 53 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| 59 | 4143 | 73 | 3H-Alniditan | -12 | 53 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| 60854 | 4143 | 73 | 3H-Alniditan | -12 | 53 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| CHEMBL708 | 4143 | 73 | 3H-Alniditan | -12 | 53 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| DB00246 | 4143 | 73 | 3H-Alniditan | -12 | 53 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| 107780 | 1844 | 54 | 35S-GTPGammaS | 1 | 17 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 14 | 1844 | 54 | 35S-GTPGammaS | 1 | 17 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| CHEMBL15928 | 1844 | 54 | 35S-GTPGammaS | 1 | 17 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 28 | 3496 | 46 | 35S-GTPGammaS | 13 | 10 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 3292447 | 3496 | 46 | 35S-GTPGammaS | 13 | 10 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| CHEMBL20963 | 3496 | 46 | 35S-GTPGammaS | 13 | 10 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| None | 215946 | 0 | 125I-ICYP | 2 | 24 | Rat | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 346 | 5 | 4 | 4 | 2.5 | COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O | None | |||
| 132 | 1275 | 13 | 3H-GR-125743 | -54 | 15 | Rat | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| 155346 | 1275 | 13 | 3H-GR-125743 | -54 | 15 | Rat | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| CHEMBL378501 | 1275 | 13 | 3H-GR-125743 | -54 | 15 | Rat | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| 5 | 139 | 72 | 3H-5HT | -11 | 54 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-5HT | -11 | 54 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-5HT | -11 | 54 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-5HT | -11 | 54 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5 | 139 | 72 | UNDEFINED | -11 | 54 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | UNDEFINED | -11 | 54 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | UNDEFINED | -11 | 54 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | UNDEFINED | -11 | 54 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 2543 | 3707 | 68 | 3H-Alniditan | -3 | 32 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | 3H-Alniditan | -3 | 32 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | 3H-Alniditan | -3 | 32 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | 3H-Alniditan | -3 | 32 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | 3H-Alniditan | -3 | 32 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 12312583 | 216017 | 0 | 3H-5HT | 1 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 254 | 1 | 2 | 2 | 2.0 | CN1CC(C=C2C1CC3=CNC4=CC=CC2=C34)CO | None | |||
| 107780 | 1844 | 54 | 3H-5HT | 1 | 17 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 14 | 1844 | 54 | 3H-5HT | 1 | 17 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| CHEMBL15928 | 1844 | 54 | 3H-5HT | 1 | 17 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 107780 | 1844 | 54 | 3H-GR-125743 | 1 | 17 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 14 | 1844 | 54 | 3H-GR-125743 | 1 | 17 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| CHEMBL15928 | 1844 | 54 | 3H-GR-125743 | 1 | 17 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 24881752 | 171759 | 0 | UNDEFINED | -1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 638 | 14 | 4 | 4 | 8.4 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | None | |||
| CHEMBL446745 | 171759 | 0 | UNDEFINED | -1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 638 | 14 | 4 | 4 | 8.4 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | None | |||
| 24881202 | 172586 | 0 | UNDEFINED | -1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 596 | 11 | 4 | 4 | 7.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | None | |||
| CHEMBL448902 | 172586 | 0 | UNDEFINED | -1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 596 | 11 | 4 | 4 | 7.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)CCCCCCC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | None | |||
| None | 215938 | 0 | 3H-GR-125743 | -25 | 21 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 583 | 4 | 3 | 6 | 2.1 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C | None | |||
| 1809 | 134 | 32 | 3H-5HT | -15 | 36 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-5HT | -15 | 36 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-5HT | -15 | 36 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| None | 215946 | 0 | 125I-ICYP | 2 | 24 | Rat | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 346 | 5 | 4 | 4 | 2.5 | COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O | None | |||
| 107 | 141 | 121 | 3H-5HT | -30 | 30 | Rat | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1833 | 141 | 121 | 3H-5HT | -30 | 30 | Rat | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| CHEMBL8165 | 141 | 121 | 3H-5HT | -30 | 30 | Rat | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 107 | 141 | 121 | 3H-5HT | -30 | 30 | Rat | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1833 | 141 | 121 | 3H-5HT | -30 | 30 | Rat | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| CHEMBL8165 | 141 | 121 | 3H-5HT | -30 | 30 | Rat | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 132 | 1275 | 13 | 125I-CYP | -54 | 15 | Rat | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| 155346 | 1275 | 13 | 125I-CYP | -54 | 15 | Rat | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| CHEMBL378501 | 1275 | 13 | 125I-CYP | -54 | 15 | Rat | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| 2543 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 1809 | 134 | 32 | 3H-5HT | -97 | 36 | Mouse | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-5HT | -97 | 36 | Mouse | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-5HT | -97 | 36 | Mouse | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| None | 215946 | 0 | 3H-5HT | -7 | 24 | Mouse | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 346 | 5 | 4 | 4 | 2.5 | COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O | None | |||
| 71299720 | 215951 | 0 | 3H-5HT | 1 | 17 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 450 | 3 | 2 | 6 | 3.0 | CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4.C(=CC(=O)O)C(=O)O | None | |||
| 11954224 | 215953 | 0 | None | -12 | 58 | Rat | 8.0 | pKi | = | 8 | Binding | Drug Central | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
| 1342 | 35 | 49 | 3H-5HT | -4 | 19 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| 3 | 35 | 49 | 3H-5HT | -4 | 19 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| CHEMBL277120 | 35 | 49 | 3H-5HT | -4 | 19 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| 4106 | 2502 | 22 | 3H-5HT | -102 | 34 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 5358812 | 2502 | 22 | 3H-5HT | -102 | 34 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 89 | 2502 | 22 | 3H-5HT | -102 | 34 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| CHEMBL93240 | 2502 | 22 | 3H-5HT | -102 | 34 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| None | 216343 | 0 | 3H-GR-125743 | 1 | 2 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 228 | 2 | 1 | 3 | 2.6 | C1CNCCC1SC2=NC(=CC=C2)Cl | None | |||
| 4106 | 2502 | 22 | 3H-5HT | -102 | 34 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 5358812 | 2502 | 22 | 3H-5HT | -102 | 34 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 89 | 2502 | 22 | 3H-5HT | -102 | 34 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| CHEMBL93240 | 2502 | 22 | 3H-5HT | -102 | 34 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| None | 216483 | 0 | 125I-ICYP | -58 | 3 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | None | None | None | None | None | |||||
| 4106 | 2502 | 22 | 3H-GR-125743 | -27 | 34 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 5358812 | 2502 | 22 | 3H-GR-125743 | -27 | 34 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 89 | 2502 | 22 | 3H-GR-125743 | -27 | 34 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| CHEMBL93240 | 2502 | 22 | 3H-GR-125743 | -27 | 34 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 2543 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 137 | 370 | 52 | 3H-5HT | -154 | 12 | Rat | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 249 | 8 | 2 | 3 | 2.2 | C=CCc1ccccc1OCC(CNC(C)C)O | None | |||
| 2119 | 370 | 52 | 3H-5HT | -154 | 12 | Rat | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 249 | 8 | 2 | 3 | 2.2 | C=CCc1ccccc1OCC(CNC(C)C)O | None | |||
| 563 | 370 | 52 | 3H-5HT | -154 | 12 | Rat | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 249 | 8 | 2 | 3 | 2.2 | C=CCc1ccccc1OCC(CNC(C)C)O | None | |||
| 66368 | 370 | 52 | 3H-5HT | -154 | 12 | Rat | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 249 | 8 | 2 | 3 | 2.2 | C=CCc1ccccc1OCC(CNC(C)C)O | None | |||
| CHEMBL266195 | 370 | 52 | 3H-5HT | -154 | 12 | Rat | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 249 | 8 | 2 | 3 | 2.2 | C=CCc1ccccc1OCC(CNC(C)C)O | None | |||
| DB00866 | 370 | 52 | 3H-5HT | -154 | 12 | Rat | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 249 | 8 | 2 | 3 | 2.2 | C=CCc1ccccc1OCC(CNC(C)C)O | None | |||
| 4106 | 2502 | 22 | 3H-GR-125743 | -102 | 34 | Rat | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 5358812 | 2502 | 22 | 3H-GR-125743 | -102 | 34 | Rat | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 89 | 2502 | 22 | 3H-GR-125743 | -102 | 34 | Rat | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| CHEMBL93240 | 2502 | 22 | 3H-GR-125743 | -102 | 34 | Rat | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 24881617 | 188326 | 0 | UNDEFINED | -165 | 2 | Human | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 756 | 13 | 4 | 4 | 10.1 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | None | |||
| CHEMBL500737 | 188326 | 0 | UNDEFINED | -165 | 2 | Human | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 756 | 13 | 4 | 4 | 10.1 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | None | |||
| 152 | 364 | 29 | 125I-CYP | -57 | 18 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | |||
| 2107 | 364 | 29 | 125I-CYP | -57 | 18 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | |||
| CHEMBL275854 | 364 | 29 | 125I-CYP | -57 | 18 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | |||
| 41 | 1659 | 0 | 3H-5CT | -794 | 17 | Guinea pig | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 195 | 0 | 1 | 3 | 0.9 | Fc1cccc2c1O[C@H]1CNC[C@@H]1O2 | None | |||
| 41 | 1659 | 0 | 3H-GR-125743 | -794 | 17 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 195 | 0 | 1 | 3 | 0.9 | Fc1cccc2c1O[C@H]1CNC[C@@H]1O2 | None | |||
| 72036 | 1659 | 0 | 3H-5CT | -794 | 17 | Guinea pig | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 195 | 0 | 1 | 3 | 0.9 | Fc1cccc2c1O[C@H]1CNC[C@@H]1O2 | None | |||
| 72036 | 1659 | 0 | 3H-GR-125743 | -794 | 17 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 195 | 0 | 1 | 3 | 0.9 | Fc1cccc2c1O[C@H]1CNC[C@@H]1O2 | None | |||
| CHEMBL1765294 | 1659 | 0 | 3H-5CT | -794 | 17 | Guinea pig | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 195 | 0 | 1 | 3 | 0.9 | Fc1cccc2c1O[C@H]1CNC[C@@H]1O2 | None | |||
| CHEMBL1765294 | 1659 | 0 | 3H-GR-125743 | -794 | 17 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 195 | 0 | 1 | 3 | 0.9 | Fc1cccc2c1O[C@H]1CNC[C@@H]1O2 | None | |||
| 173 | 3262 | 95 | 3H-5HT | -11 | 23 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | None | |||
| 5011 | 3262 | 95 | 3H-5HT | -11 | 23 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | None | |||
| CHEMBL18772 | 3262 | 95 | 3H-5HT | -11 | 23 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | None | |||
| 2605 | 3783 | 30 | 3H-GR-125743 | -218 | 10 | Guinea pig | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 295 | 5 | 2 | 4 | 2.9 | OC(COc1cccc2c1SCCC2)CNC(C)(C)C | None | |||
| 36920 | 3783 | 30 | 3H-GR-125743 | -218 | 10 | Guinea pig | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 295 | 5 | 2 | 4 | 2.9 | OC(COc1cccc2c1SCCC2)CNC(C)(C)C | None | |||
| 571 | 3783 | 30 | 3H-GR-125743 | -218 | 10 | Guinea pig | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 295 | 5 | 2 | 4 | 2.9 | OC(COc1cccc2c1SCCC2)CNC(C)(C)C | None | |||
| CHEMBL434200 | 3783 | 30 | 3H-GR-125743 | -218 | 10 | Guinea pig | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 295 | 5 | 2 | 4 | 2.9 | OC(COc1cccc2c1SCCC2)CNC(C)(C)C | None | |||
| DB13775 | 3783 | 30 | 3H-GR-125743 | -218 | 10 | Guinea pig | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 295 | 5 | 2 | 4 | 2.9 | OC(COc1cccc2c1SCCC2)CNC(C)(C)C | None | |||
| 18922713 | 98498 | 0 | 3H-5HT | -12882 | 9 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 298 | 6 | 1 | 2 | 4.0 | CCCN(CCC)C1Cc2c[nH]c3ccc(C(C)=O)c(c23)C1 | None | |||
| CHEMBL276031 | 98498 | 0 | 3H-5HT | -12882 | 9 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 298 | 6 | 1 | 2 | 4.0 | CCCN(CCC)C1Cc2c[nH]c3ccc(C(C)=O)c(c23)C1 | None | |||
| 24840389 | 115213 | 4 | 3H-GR-125743 | -741 | 16 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 415 | 9 | 0 | 4 | 4.6 | CCCN(CCC)C1CCc2cc(CS(=O)(=O)c3ccc(OC)cc3)ccc2C1 | None | |||
| CHEMBL334529 | 115213 | 4 | 3H-GR-125743 | -741 | 16 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 415 | 9 | 0 | 4 | 4.6 | CCCN(CCC)C1CCc2cc(CS(=O)(=O)c3ccc(OC)cc3)ccc2C1 | None | |||
| 12016890 | 190776 | 6 | 3H-CYANOPINDOLOL | -1698 | 11 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 318 | 4 | 1 | 3 | 2.6 | NC(=O)c1ccc(F)c2c1CC(N(C1CCC1)C1CCC1)CO2 | None | |||
| CHEMBL5183389 | 190776 | 6 | 3H-CYANOPINDOLOL | -1698 | 11 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 318 | 4 | 1 | 3 | 2.6 | NC(=O)c1ccc(F)c2c1CC(N(C1CCC1)C1CCC1)CO2 | None | |||
| 54841 | 203127 | 52 | 3H-5HT | 1 | 27 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 255 | 6 | 1 | 2 | 3.7 | CNCC[C@@H](Oc1ccccc1C)c1ccccc1 | None | |||
| CHEMBL641 | 203127 | 52 | 3H-5HT | 1 | 27 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 255 | 6 | 1 | 2 | 3.7 | CNCC[C@@H](Oc1ccccc1C)c1ccccc1 | None | |||
| None | 216379 | 0 | UNDEFINED | -1122 | 11 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 243 | 3 | 1 | 4 | 2.7 | CCC1=CC2=C(O1)C=CC3=C2N(N=C3)CC(C)N | None | |||
| None | 217236 | 0 | UNDEFINED | 1 | 2 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 768 | 9 | 4 | 4 | 9.4 | C1CN(CCC1C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F)CC(C(F)(F)F)N5CCC(CC5)C6=CNC7=C6C=C(C=C7)NC(=O)C8=CC=C(C=C8)F | None | |||
| None | 217237 | 0 | UNDEFINED | 1 | 2 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 507 | 13 | 3 | 3 | 6.9 | C1CN(CCC1C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F)CCCCCCCCCC(=O)O | None | |||
| None | 217238 | 0 | UNDEFINED | 1 | 2 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 422 | 7 | 2 | 3 | 4.7 | CN(C)CCCN1CCC(CC1)C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F | None | |||
| None | 217239 | 0 | UNDEFINED | 1 | 2 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 448 | 6 | 2 | 3 | 5.2 | C1CCN(CC1)CCN2CCC(CC2)C3=CNC4=C3C=C(C=C4)NC(=O)C5=CC=C(C=C5)F | None | |||
| None | 217240 | 0 | UNDEFINED | 1 | 2 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 381 | 5 | 3 | 3 | 3.7 | C1CN(CCC1C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F)CCO | None | |||
| None | 217241 | 0 | UNDEFINED | 1 | 2 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 427 | 5 | 2 | 2 | 5.9 | C1CN(CCC1C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F)CC5=CC=CC=C5 | None | |||
| None | 217242 | 0 | UNDEFINED | 1 | 2 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 449 | 10 | 2 | 2 | 7.1 | CCCCCCCCN1CCC(CC1)C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F | None | |||
| None | 217243 | 0 | UNDEFINED | 1 | 2 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 743 | 10 | 5 | 5 | 7.3 | C1CN(CCC1C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F)CC(C(=O)N)N5CCC(CC5)C6=CNC7=C6C=C(C=C7)NC(=O)C8=CC=C(C=C8)F | None | |||
| 3075702 | 217332 | 0 | 125I-CYP | -2 | 37 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 198 | 3 | 1 | 3 | 1.5 | C1CNC1COC2=CN=C(C=C2)Cl | None | |||
| 1574 | 81 | 60 | 125I-CYP | -24 | 21 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | None | |||
| 1574 | 81 | 60 | 3H-5HT | -24 | 21 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | None | |||
| 218 | 81 | 60 | 125I-CYP | -24 | 21 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | None | |||
| 218 | 81 | 60 | 3H-5HT | -24 | 21 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | None | |||
| CHEMBL266591 | 81 | 60 | 125I-CYP | -24 | 21 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | None | |||
| CHEMBL266591 | 81 | 60 | 3H-5HT | -24 | 21 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | None | |||
| 1192 | 147 | 47 | 3H-5HT | -162 | 17 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 311 | 2 | 3 | 5 | 0.5 | NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N | None | |||
| 1794 | 147 | 47 | 3H-5HT | -162 | 17 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 311 | 2 | 3 | 5 | 0.5 | NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N | None | |||
| CHEMBL501701 | 147 | 47 | 3H-5HT | -162 | 17 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 311 | 2 | 3 | 5 | 0.5 | NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N | None | |||
| 1220 | 187 | 55 | 125I-CYP | -7413 | 44 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 1220 | 187 | 55 | 125I-ICYP | -7413 | 44 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 1220 | 187 | 55 | 3H-5HT | -7413 | 44 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 31 | 187 | 55 | 125I-CYP | -7413 | 44 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 31 | 187 | 55 | 125I-ICYP | -7413 | 44 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 31 | 187 | 55 | 3H-5HT | -7413 | 44 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 7 | 187 | 55 | 125I-CYP | -7413 | 44 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 7 | 187 | 55 | 125I-ICYP | -7413 | 44 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 7 | 187 | 55 | 3H-5HT | -7413 | 44 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| CHEMBL56 | 187 | 55 | 125I-CYP | -7413 | 44 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| CHEMBL56 | 187 | 55 | 125I-ICYP | -7413 | 44 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| CHEMBL56 | 187 | 55 | 3H-5HT | -7413 | 44 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 179 | 400 | 115 | 3H-5HT | -4365 | 49 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| 2159 | 400 | 115 | 3H-5HT | -4365 | 49 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| 963 | 400 | 115 | 3H-5HT | -4365 | 49 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| CHEMBL243712 | 400 | 115 | 3H-5HT | -4365 | 49 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| DB06288 | 400 | 115 | 3H-5HT | -4365 | 49 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| 242 | 470 | 124 | 3H-5CT | -380 | 51 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| 34 | 470 | 124 | 3H-5CT | -380 | 51 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| 60795 | 470 | 124 | 3H-5CT | -380 | 51 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| CHEMBL1112 | 470 | 124 | 3H-5CT | -380 | 51 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| DB01238 | 470 | 124 | 3H-5CT | -380 | 51 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| 2249 | 512 | 111 | 125I-CYP | -295 | 12 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 266 | 8 | 3 | 4 | 0.5 | OC(COc1ccc(cc1)CC(=O)N)CNC(C)C | None | |||
| 2249 | 512 | 111 | 125I-ICYP | -295 | 12 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 266 | 8 | 3 | 4 | 0.5 | OC(COc1ccc(cc1)CC(=O)N)CNC(C)C | None | |||
| 2249 | 512 | 111 | 3H-5HT | -295 | 12 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 266 | 8 | 3 | 4 | 0.5 | OC(COc1ccc(cc1)CC(=O)N)CNC(C)C | None | |||
| 255 | 512 | 111 | 125I-CYP | -295 | 12 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 266 | 8 | 3 | 4 | 0.5 | OC(COc1ccc(cc1)CC(=O)N)CNC(C)C | None | |||
| 255 | 512 | 111 | 125I-ICYP | -295 | 12 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 266 | 8 | 3 | 4 | 0.5 | OC(COc1ccc(cc1)CC(=O)N)CNC(C)C | None | |||
| 255 | 512 | 111 | 3H-5HT | -295 | 12 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 266 | 8 | 3 | 4 | 0.5 | OC(COc1ccc(cc1)CC(=O)N)CNC(C)C | None | |||
| 548 | 512 | 111 | 125I-CYP | -295 | 12 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 266 | 8 | 3 | 4 | 0.5 | OC(COc1ccc(cc1)CC(=O)N)CNC(C)C | None | |||
| 548 | 512 | 111 | 125I-ICYP | -295 | 12 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 266 | 8 | 3 | 4 | 0.5 | OC(COc1ccc(cc1)CC(=O)N)CNC(C)C | None | |||
| 548 | 512 | 111 | 3H-5HT | -295 | 12 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 266 | 8 | 3 | 4 | 0.5 | OC(COc1ccc(cc1)CC(=O)N)CNC(C)C | None | |||
| CHEMBL24 | 512 | 111 | 125I-CYP | -295 | 12 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 266 | 8 | 3 | 4 | 0.5 | OC(COc1ccc(cc1)CC(=O)N)CNC(C)C | None | |||
| CHEMBL24 | 512 | 111 | 125I-ICYP | -295 | 12 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 266 | 8 | 3 | 4 | 0.5 | OC(COc1ccc(cc1)CC(=O)N)CNC(C)C | None | |||
| CHEMBL24 | 512 | 111 | 3H-5HT | -295 | 12 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 266 | 8 | 3 | 4 | 0.5 | OC(COc1ccc(cc1)CC(=O)N)CNC(C)C | None | |||
| DB00335 | 512 | 111 | 125I-CYP | -295 | 12 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 266 | 8 | 3 | 4 | 0.5 | OC(COc1ccc(cc1)CC(=O)N)CNC(C)C | None | |||
| DB00335 | 512 | 111 | 125I-ICYP | -295 | 12 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 266 | 8 | 3 | 4 | 0.5 | OC(COc1ccc(cc1)CC(=O)N)CNC(C)C | None | |||
| DB00335 | 512 | 111 | 3H-5HT | -295 | 12 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 266 | 8 | 3 | 4 | 0.5 | OC(COc1ccc(cc1)CC(=O)N)CNC(C)C | None | |||
| 2369 | 622 | 80 | 125I-ICYP | -3235 | 8 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 307 | 11 | 2 | 4 | 2.4 | OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C | None | |||
| 2369 | 622 | 80 | 3H-5HT | -3235 | 8 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 307 | 11 | 2 | 4 | 2.4 | OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C | None | |||
| 356 | 622 | 80 | 125I-ICYP | -3235 | 8 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 307 | 11 | 2 | 4 | 2.4 | OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C | None | |||
| 356 | 622 | 80 | 3H-5HT | -3235 | 8 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 307 | 11 | 2 | 4 | 2.4 | OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C | None | |||
| 549 | 622 | 80 | 125I-ICYP | -3235 | 8 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 307 | 11 | 2 | 4 | 2.4 | OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C | None | |||
| 549 | 622 | 80 | 3H-5HT | -3235 | 8 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 307 | 11 | 2 | 4 | 2.4 | OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C | None | |||
| CHEMBL423 | 622 | 80 | 125I-ICYP | -3235 | 8 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 307 | 11 | 2 | 4 | 2.4 | OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C | None | |||
| CHEMBL423 | 622 | 80 | 3H-5HT | -3235 | 8 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 307 | 11 | 2 | 4 | 2.4 | OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C | None | |||
| DB00195 | 622 | 80 | 125I-ICYP | -3235 | 8 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 307 | 11 | 2 | 4 | 2.4 | OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C | None | |||
| DB00195 | 622 | 80 | 3H-5HT | -3235 | 8 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 307 | 11 | 2 | 4 | 2.4 | OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C | None | |||
| 2477 | 745 | 59 | 125I-CYP | -16 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| 2477 | 745 | 59 | 125I-ICYP | -16 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| 2477 | 745 | 59 | 3H-5HT | -16 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| 36 | 745 | 59 | 125I-CYP | -16 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| 36 | 745 | 59 | 125I-ICYP | -16 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| 36 | 745 | 59 | 3H-5HT | -16 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| 437 | 745 | 59 | 125I-CYP | -16 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| 437 | 745 | 59 | 125I-ICYP | -16 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| 437 | 745 | 59 | 3H-5HT | -16 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| CHEMBL49 | 745 | 59 | 125I-CYP | -16 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| CHEMBL49 | 745 | 59 | 125I-ICYP | -16 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| CHEMBL49 | 745 | 59 | 3H-5HT | -16 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| DB00490 | 745 | 59 | 125I-CYP | -16 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| DB00490 | 745 | 59 | 125I-ICYP | -16 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| DB00490 | 745 | 59 | 3H-5HT | -16 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| 2398 | 954 | 62 | 3H-GR-125743 | -1230 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 314 | 4 | 0 | 2 | 4.5 | CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C | None | |||
| 2801 | 954 | 62 | 3H-GR-125743 | -1230 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 314 | 4 | 0 | 2 | 4.5 | CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C | None | |||
| 701 | 954 | 62 | 3H-GR-125743 | -1230 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 314 | 4 | 0 | 2 | 4.5 | CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C | None | |||
| CHEMBL415 | 954 | 62 | 3H-GR-125743 | -1230 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 314 | 4 | 0 | 2 | 4.5 | CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C | None | |||
| DB01242 | 954 | 62 | 3H-GR-125743 | -1230 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 314 | 4 | 0 | 2 | 4.5 | CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C | None | |||
| 2803 | 955 | 58 | 125I-ICYP | -602 | 19 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 229 | 1 | 2 | 3 | 2.4 | Clc1cccc(c1NC1=NCCN1)Cl | None | |||
| 516 | 955 | 58 | 125I-ICYP | -602 | 19 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 229 | 1 | 2 | 3 | 2.4 | Clc1cccc(c1NC1=NCCN1)Cl | None | |||
| 704 | 955 | 58 | 125I-ICYP | -602 | 19 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 229 | 1 | 2 | 3 | 2.4 | Clc1cccc(c1NC1=NCCN1)Cl | None | |||
| CHEMBL134 | 955 | 58 | 125I-ICYP | -602 | 19 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 229 | 1 | 2 | 3 | 2.4 | Clc1cccc(c1NC1=NCCN1)Cl | None | |||
| DB00575 | 955 | 58 | 125I-ICYP | -602 | 19 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 229 | 1 | 2 | 3 | 2.4 | Clc1cccc(c1NC1=NCCN1)Cl | None | |||
| 141 | 1427 | 35 | 3H-5-CT | -114 | 22 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | None | |||
| 6089 | 1427 | 35 | 3H-5-CT | -114 | 22 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | None | |||
| CHEMBL12420 | 1427 | 35 | 3H-5-CT | -114 | 22 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | None | |||
| DB01488 | 1427 | 35 | 3H-5-CT | -114 | 22 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | None | |||
| 681 | 1465 | 72 | 125I-CYP | -1995 | 39 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | |||
| 940 | 1465 | 72 | 125I-CYP | -1995 | 39 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | |||
| 947 | 1465 | 72 | 125I-CYP | -1995 | 39 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | |||
| CHEMBL59 | 1465 | 72 | 125I-CYP | -1995 | 39 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | |||
| DB00988 | 1465 | 72 | 125I-CYP | -1995 | 39 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | |||
| 1353 | 1911 | 93 | 3H-5HT | -5248 | 83 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 3559 | 1911 | 93 | 3H-5HT | -5248 | 83 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 86 | 1911 | 93 | 3H-5HT | -5248 | 83 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| CHEMBL54 | 1911 | 93 | 3H-5HT | -5248 | 83 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| DB00502 | 1911 | 93 | 3H-5HT | -5248 | 83 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 1204 | 1932 | 119 | 3H-5HT | -1949 | 24 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | |||
| 1247 | 1932 | 119 | 3H-5HT | -1949 | 24 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | |||
| 1375 | 1932 | 119 | 3H-5HT | -1949 | 24 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | |||
| 774 | 1932 | 119 | 3H-5HT | -1949 | 24 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | |||
| CHEMBL90 | 1932 | 119 | 3H-5HT | -1949 | 24 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | |||
| DB05381 | 1932 | 119 | 3H-5HT | -1949 | 24 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | |||
| 12575 | 1988 | 30 | 125I-CYP | -6606 | 17 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 204 | 1 | 1 | 4 | 0.8 | C1CN=C(N1)C2COC3=CC=CC=C3O2 | None | |||
| 54459 | 1988 | 30 | 125I-CYP | -6606 | 17 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 204 | 1 | 1 | 4 | 0.8 | C1CN=C(N1)C2COC3=CC=CC=C3O2 | None | |||
| CHEMBL10316 | 1988 | 30 | 125I-CYP | -6606 | 17 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 204 | 1 | 1 | 4 | 0.8 | C1CN=C(N1)C2COC3=CC=CC=C3O2 | None | |||
| 42 | 2063 | 57 | 3H-5HT | -1778 | 18 | Bovine | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| 42 | 2063 | 57 | 125I-CYP | -1778 | 18 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| 42 | 2063 | 57 | 125I-ICYP | -1778 | 18 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| 42 | 2063 | 57 | 3H-5HT | -1778 | 18 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| 56971 | 2063 | 57 | 3H-5HT | -1778 | 18 | Bovine | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| 56971 | 2063 | 57 | 125I-CYP | -1778 | 18 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| 56971 | 2063 | 57 | 125I-ICYP | -1778 | 18 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| 56971 | 2063 | 57 | 3H-5HT | -1778 | 18 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| CHEMBL8412 | 2063 | 57 | 3H-5HT | -1778 | 18 | Bovine | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| CHEMBL8412 | 2063 | 57 | 125I-CYP | -1778 | 18 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| CHEMBL8412 | 2063 | 57 | 125I-ICYP | -1778 | 18 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| CHEMBL8412 | 2063 | 57 | 3H-5HT | -1778 | 18 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| 1524 | 2181 | 96 | 3H-GR-125743 | -7585 | 52 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 1524 | 2181 | 96 | 125I-ICYP | -512 | 52 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 1524 | 2181 | 96 | 3H-5HT | -512 | 52 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 1524 | 2181 | 96 | 3H-GR-125743 | -512 | 52 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 197 | 2181 | 96 | 3H-GR-125743 | -7585 | 52 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 197 | 2181 | 96 | 125I-ICYP | -512 | 52 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 197 | 2181 | 96 | 3H-5HT | -512 | 52 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 197 | 2181 | 96 | 3H-GR-125743 | -512 | 52 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 3822 | 2181 | 96 | 3H-GR-125743 | -7585 | 52 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 3822 | 2181 | 96 | 125I-ICYP | -512 | 52 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 3822 | 2181 | 96 | 3H-5HT | -512 | 52 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 3822 | 2181 | 96 | 3H-GR-125743 | -512 | 52 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 88 | 2181 | 96 | 3H-GR-125743 | -7585 | 52 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 88 | 2181 | 96 | 125I-ICYP | -512 | 52 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 88 | 2181 | 96 | 3H-5HT | -512 | 52 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 88 | 2181 | 96 | 3H-GR-125743 | -512 | 52 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| CHEMBL51 | 2181 | 96 | 3H-GR-125743 | -7585 | 52 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| CHEMBL51 | 2181 | 96 | 125I-ICYP | -512 | 52 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| CHEMBL51 | 2181 | 96 | 3H-5HT | -512 | 52 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| CHEMBL51 | 2181 | 96 | 3H-GR-125743 | -512 | 52 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| DB12465 | 2181 | 96 | 3H-GR-125743 | -7585 | 52 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| DB12465 | 2181 | 96 | 125I-ICYP | -512 | 52 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| DB12465 | 2181 | 96 | 3H-5HT | -512 | 52 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| DB12465 | 2181 | 96 | 3H-GR-125743 | -512 | 52 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 1531 | 2266 | 69 | 125I-CYP | -676 | 16 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 328 | 8 | 5 | 4 | 2.9 | CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O | None | |||
| 3869 | 2266 | 69 | 125I-CYP | -676 | 16 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 328 | 8 | 5 | 4 | 2.9 | CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O | None | |||
| 7207 | 2266 | 69 | 125I-CYP | -676 | 16 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 328 | 8 | 5 | 4 | 2.9 | CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O | None | |||
| CHEMBL429 | 2266 | 69 | 125I-CYP | -676 | 16 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 328 | 8 | 5 | 4 | 2.9 | CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O | None | |||
| DB00598 | 2266 | 69 | 125I-CYP | -676 | 16 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 328 | 8 | 5 | 4 | 2.9 | CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O | None | |||
| 206 | 2493 | 16 | 125I-CYP | -7585 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | None | |||
| 206 | 2493 | 16 | 125I-ICYP | -7585 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | None | |||
| 206 | 2493 | 16 | 3H-5HT | -7585 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | None | |||
| 68848 | 2493 | 16 | 125I-CYP | -7585 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | None | |||
| 68848 | 2493 | 16 | 125I-ICYP | -7585 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | None | |||
| 68848 | 2493 | 16 | 3H-5HT | -7585 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | None | |||
| CHEMBL12314 | 2493 | 16 | 125I-CYP | -7585 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | None | |||
| CHEMBL12314 | 2493 | 16 | 125I-ICYP | -7585 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | None | |||
| CHEMBL12314 | 2493 | 16 | 3H-5HT | -7585 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | None | |||
| 1786 | 2520 | 85 | 3H-5-CT | -524 | 11 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 267 | 9 | 2 | 4 | 1.6 | COCCc1ccc(cc1)OCC(CNC(C)C)O | None | |||
| 1786 | 2520 | 85 | 125I-ICYP | -524 | 11 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 267 | 9 | 2 | 4 | 1.6 | COCCc1ccc(cc1)OCC(CNC(C)C)O | None | |||
| 4171 | 2520 | 85 | 3H-5-CT | -524 | 11 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 267 | 9 | 2 | 4 | 1.6 | COCCc1ccc(cc1)OCC(CNC(C)C)O | None | |||
| 4171 | 2520 | 85 | 125I-ICYP | -524 | 11 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 267 | 9 | 2 | 4 | 1.6 | COCCc1ccc(cc1)OCC(CNC(C)C)O | None | |||
| 553 | 2520 | 85 | 3H-5-CT | -524 | 11 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 267 | 9 | 2 | 4 | 1.6 | COCCc1ccc(cc1)OCC(CNC(C)C)O | None | |||
| 553 | 2520 | 85 | 125I-ICYP | -524 | 11 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 267 | 9 | 2 | 4 | 1.6 | COCCc1ccc(cc1)OCC(CNC(C)C)O | None | |||
| CHEMBL13 | 2520 | 85 | 3H-5-CT | -524 | 11 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 267 | 9 | 2 | 4 | 1.6 | COCCc1ccc(cc1)OCC(CNC(C)C)O | None | |||
| CHEMBL13 | 2520 | 85 | 125I-ICYP | -524 | 11 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 267 | 9 | 2 | 4 | 1.6 | COCCc1ccc(cc1)OCC(CNC(C)C)O | None | |||
| DB00264 | 2520 | 85 | 3H-5-CT | -524 | 11 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 267 | 9 | 2 | 4 | 1.6 | COCCc1ccc(cc1)OCC(CNC(C)C)O | None | |||
| DB00264 | 2520 | 85 | 125I-ICYP | -524 | 11 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 267 | 9 | 2 | 4 | 1.6 | COCCc1ccc(cc1)OCC(CNC(C)C)O | None | |||
| 135 | 2532 | 43 | 3H-5HT | -851 | 58 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 1796 | 2532 | 43 | 3H-5HT | -851 | 58 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 4184 | 2532 | 43 | 3H-5HT | -851 | 58 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| CHEMBL6437 | 2532 | 43 | 3H-5HT | -851 | 58 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| DB06148 | 2532 | 43 | 3H-5HT | -851 | 58 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 484 | 2858 | 51 | 125I-ICYP | -24 | 35 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 169 | 2 | 4 | 4 | 0.1 | NCC(c1ccc(c(c1)O)O)O | None | |||
| 951 | 2858 | 51 | 125I-ICYP | -24 | 35 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 169 | 2 | 4 | 4 | 0.1 | NCC(c1ccc(c(c1)O)O)O | None | |||
| CHEMBL432 | 2858 | 51 | 125I-ICYP | -24 | 35 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 169 | 2 | 4 | 4 | 0.1 | NCC(c1ccc(c(c1)O)O)O | None | |||
| 283 | 3130 | 57 | 3H-5HT | -6606 | 12 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 393 | 5 | 0 | 5 | 3.3 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2 | None | |||
| 4847 | 3130 | 57 | 3H-5HT | -6606 | 12 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 393 | 5 | 0 | 5 | 3.3 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2 | None | |||
| CHEMBL18331 | 3130 | 57 | 3H-5HT | -6606 | 12 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 393 | 5 | 0 | 5 | 3.3 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2 | None | |||
| 2202 | 3132 | 96 | 3H-GR-125743 | -316 | 21 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | None | |||
| 4850 | 3132 | 96 | 3H-GR-125743 | -316 | 21 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | None | |||
| 49 | 3132 | 96 | 3H-GR-125743 | -316 | 21 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | None | |||
| CHEMBL1371770 | 3132 | 96 | 3H-GR-125743 | -316 | 21 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | None | |||
| DB12478 | 3132 | 96 | 3H-GR-125743 | -316 | 21 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | None | |||
| 2220 | 3134 | 82 | 125I-ICYP | -1023 | 14 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 295 | 0 | 0 | 2 | 4.4 | CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 | None | |||
| 27400 | 3134 | 82 | 125I-ICYP | -1023 | 14 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 295 | 0 | 0 | 2 | 4.4 | CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 | None | |||
| 93 | 3134 | 82 | 125I-ICYP | -1023 | 14 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 295 | 0 | 0 | 2 | 4.4 | CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 | None | |||
| CHEMBL294951 | 3134 | 82 | 125I-ICYP | -1023 | 14 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 295 | 0 | 0 | 2 | 4.4 | CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 | None | |||
| DB06153 | 3134 | 82 | 125I-ICYP | -1023 | 14 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 295 | 0 | 0 | 2 | 4.4 | CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 | None | |||
| 3486 | 3157 | 56 | 125I-ICYP | -204 | 11 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 266 | 7 | 3 | 4 | 1.4 | OC(COc1ccc(cc1)NC(=O)C)CNC(C)C | None | |||
| 4883 | 3157 | 56 | 125I-ICYP | -204 | 11 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 266 | 7 | 3 | 4 | 1.4 | OC(COc1ccc(cc1)NC(=O)C)CNC(C)C | None | |||
| 555 | 3157 | 56 | 125I-ICYP | -204 | 11 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 266 | 7 | 3 | 4 | 1.4 | OC(COc1ccc(cc1)NC(=O)C)CNC(C)C | None | |||
| CHEMBL6995 | 3157 | 56 | 125I-ICYP | -204 | 11 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 266 | 7 | 3 | 4 | 1.4 | OC(COc1ccc(cc1)NC(=O)C)CNC(C)C | None | |||
| DB01297 | 3157 | 56 | 125I-ICYP | -204 | 11 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 266 | 7 | 3 | 4 | 1.4 | OC(COc1ccc(cc1)NC(=O)C)CNC(C)C | None | |||
| 2303 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 4946 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 564 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 63 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 91536 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| CHEMBL27 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| CHEMBL452861 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| DB00571 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 243 | 3202 | 91 | 3H-Alniditan | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | |||
| 3052762 | 3202 | 91 | 3H-Alniditan | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | |||
| 3502 | 3202 | 91 | 3H-Alniditan | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | |||
| CHEMBL117287 | 3202 | 91 | 3H-Alniditan | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | |||
| DB06480 | 3202 | 91 | 3H-Alniditan | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | |||
| 2 | 3261 | 23 | 3H-GR-125743 | -2089 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | None | |||
| 54562 | 3261 | 23 | 3H-GR-125743 | -2089 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | None | |||
| CHEMBL240773 | 3261 | 23 | 3H-GR-125743 | -2089 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | None | |||
| 5074 | 3332 | 80 | 125I-CYP | -4168 | 30 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | None | |||
| 5074 | 3332 | 80 | 3H-GR-125743 | -4168 | 30 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | None | |||
| 97 | 3332 | 80 | 125I-CYP | -4168 | 30 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | None | |||
| 97 | 3332 | 80 | 3H-GR-125743 | -4168 | 30 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | None | |||
| CHEMBL267777 | 3332 | 80 | 125I-CYP | -4168 | 30 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | None | |||
| CHEMBL267777 | 3332 | 80 | 3H-GR-125743 | -4168 | 30 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | None | |||
| DB12693 | 3332 | 80 | 125I-CYP | -4168 | 30 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | None | |||
| DB12693 | 3332 | 80 | 3H-GR-125743 | -4168 | 30 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | None | |||
| 2402 | 3370 | 62 | 3H-GR-125743 | -660 | 24 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | |||
| 5095 | 3370 | 62 | 3H-GR-125743 | -660 | 24 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | |||
| 7295 | 3370 | 62 | 3H-GR-125743 | -660 | 24 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | |||
| CHEMBL589 | 3370 | 62 | 3H-GR-125743 | -660 | 24 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | |||
| DB00268 | 3370 | 62 | 3H-GR-125743 | -660 | 24 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | |||
| 128563 | 3464 | 33 | 3H-5-CT | -2398 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 432 | 3 | 0 | 8 | 3.0 | COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 | None | |||
| 128563 | 3464 | 33 | 3H-GR-125743 | -2398 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 432 | 3 | 0 | 8 | 3.0 | COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 | None | |||
| 1666 | 3464 | 33 | 3H-5-CT | -2398 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 432 | 3 | 0 | 8 | 3.0 | COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 | None | |||
| 1666 | 3464 | 33 | 3H-GR-125743 | -2398 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 432 | 3 | 0 | 8 | 3.0 | COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 | None | |||
| CHEMBL445332 | 3464 | 33 | 3H-5-CT | -2398 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 432 | 3 | 0 | 8 | 3.0 | COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 | None | |||
| CHEMBL445332 | 3464 | 33 | 3H-GR-125743 | -2398 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 432 | 3 | 0 | 8 | 3.0 | COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 | None | |||
| DB12327 | 3464 | 33 | 3H-5-CT | -2398 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 432 | 3 | 0 | 8 | 3.0 | COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 | None | |||
| DB12327 | 3464 | 33 | 3H-GR-125743 | -2398 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 432 | 3 | 0 | 8 | 3.0 | COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 | None | |||
| 221 | 3491 | 71 | UNDEFINED | -478 | 14 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 286 | 2 | 2 | 4 | 3.6 | O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C | None | |||
| 3277600 | 3491 | 71 | UNDEFINED | -478 | 14 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 286 | 2 | 2 | 4 | 3.6 | O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C | None | |||
| CHEMBL323356 | 3491 | 71 | UNDEFINED | -478 | 14 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 286 | 2 | 2 | 4 | 3.6 | O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C | None | |||
| 2464 | 3640 | 58 | 125I-ICYP | -165 | 6 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 272 | 6 | 3 | 4 | 1.1 | CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C | None | |||
| 5253 | 3640 | 58 | 125I-ICYP | -165 | 6 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 272 | 6 | 3 | 4 | 1.1 | CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C | None | |||
| 7297 | 3640 | 58 | 125I-ICYP | -165 | 6 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 272 | 6 | 3 | 4 | 1.1 | CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C | None | |||
| CHEMBL471 | 3640 | 58 | 125I-ICYP | -165 | 6 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 272 | 6 | 3 | 4 | 1.1 | CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C | None | |||
| DB00489 | 3640 | 58 | 125I-ICYP | -165 | 6 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 272 | 6 | 3 | 4 | 1.1 | CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C | None | |||
| 2470 | 3653 | 50 | 3H-5HT | -95499 | 59 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 2470 | 3653 | 50 | 125I-ICYP | -43651 | 59 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 2470 | 3653 | 50 | 3H-5HT | -43651 | 59 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 3300 | 3653 | 50 | 3H-5HT | -95499 | 59 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 3300 | 3653 | 50 | 125I-ICYP | -43651 | 59 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 3300 | 3653 | 50 | 3H-5HT | -43651 | 59 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 5265 | 3653 | 50 | 3H-5HT | -95499 | 59 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 5265 | 3653 | 50 | 125I-ICYP | -43651 | 59 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 5265 | 3653 | 50 | 3H-5HT | -43651 | 59 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 99 | 3653 | 50 | 3H-5HT | -95499 | 59 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 99 | 3653 | 50 | 125I-ICYP | -43651 | 59 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 99 | 3653 | 50 | 3H-5HT | -43651 | 59 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| CHEMBL267930 | 3653 | 50 | 3H-5HT | -95499 | 59 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| CHEMBL267930 | 3653 | 50 | 125I-ICYP | -43651 | 59 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| CHEMBL267930 | 3653 | 50 | 3H-5HT | -43651 | 59 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 5268 | 3656 | 40 | 125I-CYP | -31622 | 18 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 379 | 3 | 1 | 5 | 2.3 | O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 | None | |||
| 53 | 3656 | 40 | 125I-CYP | -31622 | 18 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 379 | 3 | 1 | 5 | 2.3 | O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 | None | |||
| CHEMBL300555 | 3656 | 40 | 125I-CYP | -31622 | 18 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 379 | 3 | 1 | 5 | 2.3 | O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 | None | |||
| 1267 | 3804 | 49 | 3H-5HT | -4168 | 26 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 292 | 2 | 2 | 2 | 2.8 | S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1 | None | |||
| 3035905 | 3804 | 49 | 3H-5HT | -4168 | 26 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 292 | 2 | 2 | 2 | 2.8 | S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1 | None | |||
| CHEMBL260374 | 3804 | 49 | 3H-5HT | -4168 | 26 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 292 | 2 | 2 | 2 | 2.8 | S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1 | None | |||
| 213 | 3853 | 55 | 3H-GR-125743 | -912 | 44 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | |||
| 2717 | 3853 | 55 | 3H-GR-125743 | -912 | 44 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | |||
| 5533 | 3853 | 55 | 3H-GR-125743 | -912 | 44 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | |||
| CHEMBL621 | 3853 | 55 | 3H-GR-125743 | -912 | 44 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | |||
| DB00656 | 3853 | 55 | 3H-GR-125743 | -912 | 44 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | |||
| 1150 | 3878 | 121 | 125I-CYP | -204 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | |||
| 125 | 3878 | 121 | 125I-CYP | -204 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | |||
| CHEMBL6640 | 3878 | 121 | 125I-CYP | -204 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | |||
| DB08653 | 3878 | 121 | 125I-CYP | -204 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | |||
| 185 | 4006 | 60 | 3H-GR-125743 | -30902 | 37 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 373 | 7 | 1 | 4 | 3.8 | COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O | None | |||
| 5311271 | 4006 | 60 | 3H-GR-125743 | -30902 | 37 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 373 | 7 | 1 | 4 | 3.8 | COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O | None | |||
| CHEMBL74355 | 4006 | 60 | 3H-GR-125743 | -30902 | 37 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 373 | 7 | 1 | 4 | 3.8 | COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O | None | |||
| DB16351 | 4006 | 60 | 3H-GR-125743 | -30902 | 37 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 373 | 7 | 1 | 4 | 3.8 | COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O | None | |||
| 102 | 4127 | 48 | 3H-5HT | -186 | 49 | Mouse | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 3659 | 4127 | 48 | 3H-5HT | -186 | 49 | Mouse | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 8969 | 4127 | 48 | 3H-5HT | -186 | 49 | Mouse | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| CHEMBL15245 | 4127 | 48 | 3H-5HT | -186 | 49 | Mouse | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| DB01392 | 4127 | 48 | 3H-5HT | -186 | 49 | Mouse | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 108182 | 4131 | 22 | 3H-5HT | -32 | 16 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 245 | 4131 | 22 | 3H-5HT | -32 | 16 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| CHEMBL18041 | 4131 | 22 | 3H-5HT | -32 | 16 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 2662 | 11384 | 131 | 3H-GR-125743 | -41 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 381 | 3 | 1 | 4 | 3.5 | Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 | None | |||
| CHEMBL118 | 11384 | 131 | 3H-GR-125743 | -41 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 381 | 3 | 1 | 4 | 3.5 | Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 | None | |||
| 5090 | 15561 | 106 | 3H-GR-125743 | -1348 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 314 | 3 | 0 | 4 | 2.6 | CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1 | None | |||
| CHEMBL122 | 15561 | 106 | 3H-GR-125743 | -1348 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 314 | 3 | 0 | 4 | 2.6 | CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1 | None | |||
| 671690 | 27097 | 35 | 125I-ICYP | -10 | 10 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 313 | 2 | 0 | 3 | 3.8 | CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2 | None | |||
| CHEMBL1365455 | 27097 | 35 | 125I-ICYP | -10 | 10 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 313 | 2 | 0 | 3 | 3.8 | CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2 | None | |||
| 10297 | 27112 | 30 | 3H-GR-125743 | -38 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 151 | 2 | 2 | 2 | 1.1 | C[C@H](N)[C@H](O)c1ccccc1 | None | |||
| CHEMBL136560 | 27112 | 30 | 3H-GR-125743 | -38 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 151 | 2 | 2 | 2 | 1.1 | C[C@H](N)[C@H](O)c1ccccc1 | None | |||
| 127151 | 35330 | 18 | 3H-GR-125743 | -1584 | 10 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 313 | 6 | 1 | 4 | 3.2 | CCOc1ccccc1OC(c1ccccc1)C1CNCCO1 | None | |||
| 3022645 | 35330 | 18 | 3H-GR-125743 | -1584 | 10 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 313 | 6 | 1 | 4 | 3.2 | CCOc1ccccc1OC(c1ccccc1)C1CNCCO1 | None | |||
| CHEMBL14370 | 35330 | 18 | 3H-GR-125743 | -1584 | 10 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 313 | 6 | 1 | 4 | 3.2 | CCOc1ccccc1OC(c1ccccc1)C1CNCCO1 | None | |||
| 156391 | 46800 | 99 | 3H-GR-125743 | -1 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 230 | 3 | 1 | 2 | 3.0 | COc1ccc2cc([C@H](C)C(=O)O)ccc2c1 | None | |||
| CHEMBL1200806 | 46800 | 99 | 3H-GR-125743 | -1 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 230 | 3 | 1 | 2 | 3.0 | COc1ccc2cc([C@H](C)C(=O)O)ccc2c1 | None | |||
| CHEMBL154 | 46800 | 99 | 3H-GR-125743 | -1 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 230 | 3 | 1 | 2 | 3.0 | COc1ccc2cc([C@H](C)C(=O)O)ccc2c1 | None | |||
| 5475158 | 67213 | 25 | 3H-5HT | -1023 | 14 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 340 | 8 | 1 | 3 | 4.4 | CN(C)CCCSc1ccccc1NC(=O)/C=C/c1ccccc1 | None | |||
| CHEMBL18786 | 67213 | 25 | 3H-5HT | -1023 | 14 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 340 | 8 | 1 | 3 | 4.4 | CN(C)CCCSc1ccccc1NC(=O)/C=C/c1ccccc1 | None | |||
| 10624 | 70300 | 19 | 3H-GR-125743 | -776 | 33 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 284 | 5 | 3 | 3 | 1.7 | CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 | None | |||
| 138543650 | 70300 | 19 | 3H-GR-125743 | -776 | 33 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 284 | 5 | 3 | 3 | 1.7 | CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 | None | |||
| CHEMBL194378 | 70300 | 19 | 3H-GR-125743 | -776 | 33 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 284 | 5 | 3 | 3 | 1.7 | CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 | None | |||
| 108107 | 79944 | 38 | 3H-5HT | -15 | 16 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 319 | 3 | 4 | 5 | 0.5 | N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1 | None | |||
| 156592250 | 79944 | 38 | 3H-5HT | -15 | 16 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 319 | 3 | 4 | 5 | 0.5 | N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1 | None | |||
| CHEMBL1256878 | 79944 | 38 | 3H-5HT | -15 | 16 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 319 | 3 | 4 | 5 | 0.5 | N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1 | None | |||
| CHEMBL212579 | 79944 | 38 | 3H-5HT | -15 | 16 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 319 | 3 | 4 | 5 | 0.5 | N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1 | None | |||
| 442108 | 84636 | 6 | 3H-5-CT | -1 | 12 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 310 | 2 | 1 | 2 | 3.9 | CC[C@H]1C[C@H]2C[C@H]3c4[nH]c5ccc(OC)cc5c4CCN(C2)[C@@H]13 | None | |||
| CHEMBL222287 | 84636 | 6 | 3H-5-CT | -1 | 12 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 310 | 2 | 1 | 2 | 3.9 | CC[C@H]1C[C@H]2C[C@H]3c4[nH]c5ccc(OC)cc5c4CCN(C2)[C@@H]13 | None | |||
| 2244 | 94233 | 100 | 3H-GR-125743 | -1 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 180 | 2 | 1 | 3 | 1.3 | CC(=O)Oc1ccccc1C(=O)O | None | |||
| CHEMBL25 | 94233 | 100 | 3H-GR-125743 | -1 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 180 | 2 | 1 | 3 | 1.3 | CC(=O)Oc1ccccc1C(=O)O | None | |||
| 104870 | 98880 | 47 | 3H-GR-125743 | -549 | 21 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 209 | 2 | 1 | 4 | 1.3 | C=CCN1CCc2nc(N)sc2CC1 | None | |||
| 5374 | 98880 | 47 | 3H-GR-125743 | -549 | 21 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 209 | 2 | 1 | 4 | 1.3 | C=CCN1CCc2nc(N)sc2CC1 | None | |||
| CHEMBL279085 | 98880 | 47 | 3H-GR-125743 | -549 | 21 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 209 | 2 | 1 | 4 | 1.3 | C=CCN1CCc2nc(N)sc2CC1 | None | |||
| 55191 | 99617 | 64 | 125I-CYP | -446 | 9 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 359 | 6 | 0 | 6 | 1.6 | CC1(C)CC(=O)N(CCCCN2CCN(c3ncccn3)CC2)C(=O)C1 | None | |||
| CHEMBL284092 | 99617 | 64 | 125I-CYP | -446 | 9 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 359 | 6 | 0 | 6 | 1.6 | CC1(C)CC(=O)N(CCCCN2CCN(c3ncccn3)CC2)C(=O)C1 | None | |||
| 44208932 | 140707 | 7 | UNDEFINED | -89125 | 36 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 475 | 5 | 1 | 3 | 6.8 | Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 | None | |||
| CHEMBL381689 | 140707 | 7 | UNDEFINED | -89125 | 36 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 475 | 5 | 1 | 3 | 6.8 | Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 | None | |||
| 1615 | 167791 | 24 | 3H-GR-125743 | -26 | 44 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 193 | 3 | 1 | 3 | 1.6 | CNC(C)Cc1ccc2c(c1)OCO2 | None | |||
| CHEMBL43048 | 167791 | 24 | 3H-GR-125743 | -26 | 44 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 193 | 3 | 1 | 3 | 1.6 | CNC(C)Cc1ccc2c(c1)OCO2 | None | |||
| 43815 | 186920 | 64 | 3H-5HT | -1995 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 329 | 4 | 1 | 4 | 3.3 | Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 | None | |||
| CHEMBL1708 | 186920 | 64 | 3H-5HT | -1995 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 329 | 4 | 1 | 4 | 3.3 | Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 | None | |||
| CHEMBL490 | 186920 | 64 | 3H-5HT | -1995 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 329 | 4 | 1 | 4 | 3.3 | Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 | None | |||
| 24882267 | 188327 | 0 | UNDEFINED | -776 | 2 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 840 | 19 | 4 | 4 | 12.4 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | None | |||
| CHEMBL500749 | 188327 | 0 | UNDEFINED | -776 | 2 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 840 | 19 | 4 | 4 | 12.4 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | None | |||
| 24882192 | 188802 | 0 | UNDEFINED | -125 | 2 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 714 | 10 | 4 | 4 | 8.9 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | None | |||
| CHEMBL505954 | 188802 | 0 | UNDEFINED | -125 | 2 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 714 | 10 | 4 | 4 | 8.9 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | None | |||
| 24881552 | 189111 | 0 | UNDEFINED | -45 | 2 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 700 | 9 | 4 | 4 | 8.5 | O=C(Nc1ccc2[nH]cc(C3CCN(CCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | None | |||
| CHEMBL510280 | 189111 | 0 | UNDEFINED | -45 | 2 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 700 | 9 | 4 | 4 | 8.5 | O=C(Nc1ccc2[nH]cc(C3CCN(CCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | None | |||
| 3672 | 192533 | 136 | 3H-GR-125743 | -1 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 206 | 4 | 1 | 1 | 3.1 | CC(C)Cc1ccc(C(C)C(=O)O)cc1 | None | |||
| CHEMBL521 | 192533 | 136 | 3H-GR-125743 | -1 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 206 | 4 | 1 | 1 | 3.1 | CC(C)Cc1ccc(C(C)C(=O)O)cc1 | None | |||
| 54676228 | 193615 | 112 | 3H-GR-125743 | -1 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 331 | 2 | 2 | 5 | 1.6 | CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O | None | |||
| CHEMBL527 | 193615 | 112 | 3H-GR-125743 | -1 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 331 | 2 | 2 | 5 | 1.6 | CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O | None | |||
| 2771 | 195017 | 74 | 3H-5CT | -120 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | |||
| 2771 | 195017 | 74 | 3H-GR-125743 | -120 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | |||
| 2771 | 195017 | 74 | 3H-5HT | -120 | 27 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | |||
| CHEMBL1200781 | 195017 | 74 | 3H-5CT | -120 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | |||
| CHEMBL1200781 | 195017 | 74 | 3H-GR-125743 | -120 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | |||
| CHEMBL1200781 | 195017 | 74 | 3H-5HT | -120 | 27 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | |||
| CHEMBL549 | 195017 | 74 | 3H-5CT | -120 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | |||
| CHEMBL549 | 195017 | 74 | 3H-GR-125743 | -120 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | |||
| CHEMBL549 | 195017 | 74 | 3H-5HT | -120 | 27 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | |||
| 4495 | 196535 | 92 | 3H-GR-125743 | -1 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 308 | 5 | 1 | 5 | 2.8 | CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 | None | |||
| CHEMBL56367 | 196535 | 92 | 3H-GR-125743 | -1 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 308 | 5 | 1 | 5 | 2.8 | CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 | None | |||
| 54677470 | 200551 | 115 | 3H-GR-125743 | -1 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 351 | 2 | 2 | 6 | 2.0 | Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 | None | |||
| CHEMBL1256873 | 200551 | 115 | 3H-GR-125743 | -1 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 351 | 2 | 2 | 6 | 2.0 | Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 | None | |||
| CHEMBL599 | 200551 | 115 | 3H-GR-125743 | -1 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 351 | 2 | 2 | 6 | 2.0 | Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 | None | |||
| 162265 | 202274 | 22 | 3H-GR-125743 | -239 | 43 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 151 | 2 | 2 | 2 | 1.1 | CC(N)C(O)c1ccccc1 | None | |||
| 4786 | 202274 | 22 | 3H-GR-125743 | -239 | 43 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 151 | 2 | 2 | 2 | 1.1 | CC(N)C(O)c1ccccc1 | None | |||
| CHEMBL61006 | 202274 | 22 | 3H-GR-125743 | -239 | 43 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 151 | 2 | 2 | 2 | 1.1 | CC(N)C(O)c1ccccc1 | None | |||
| 3036864 | 202754 | 19 | 125I-CYP | -41686 | 28 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | None | |||
| CHEMBL1256645 | 202754 | 19 | 125I-CYP | -41686 | 28 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | None | |||
| CHEMBL1814790 | 202754 | 19 | 125I-CYP | -41686 | 28 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | None | |||
| CHEMBL62 | 202754 | 19 | 125I-CYP | -41686 | 28 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | None | |||
| 5281600 | 203025 | 92 | 3H-5CT | -173 | 33 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 538 | 3 | 6 | 10 | 5.1 | O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12 | None | |||
| CHEMBL63354 | 203025 | 92 | 3H-5CT | -173 | 33 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 538 | 3 | 6 | 10 | 5.1 | O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12 | None | |||
| 5656 | 203066 | 87 | 3H-5HT | -79 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 277 | 5 | 1 | 3 | 3.0 | COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 | None | |||
| 5656 | 203066 | 87 | 3H-GR-125743 | -79 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 277 | 5 | 1 | 3 | 3.0 | COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 | None | |||
| CHEMBL637 | 203066 | 87 | 3H-5HT | -79 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 277 | 5 | 1 | 3 | 3.0 | COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 | None | |||
| CHEMBL637 | 203066 | 87 | 3H-GR-125743 | -79 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 277 | 5 | 1 | 3 | 3.0 | COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 | None | |||
| 1973 | 203483 | 15 | 3H-CYANOPINDOLOL | -3 | 36 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 462 | 3 | 1 | 7 | 3.9 | Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 | None | |||
| CHEMBL1394464 | 203483 | 15 | 3H-CYANOPINDOLOL | -3 | 36 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 462 | 3 | 1 | 7 | 3.9 | Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 | None | |||
| CHEMBL66089 | 203483 | 15 | 3H-CYANOPINDOLOL | -3 | 36 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 462 | 3 | 1 | 7 | 3.9 | Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 | None | |||
| 1614 | 203655 | 24 | 3H-5HT | -81 | 10 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 179 | 2 | 1 | 3 | 1.3 | CC(N)Cc1ccc2c(c1)OCO2 | None | |||
| CHEMBL6731 | 203655 | 24 | 3H-5HT | -81 | 10 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 179 | 2 | 1 | 3 | 1.3 | CC(N)Cc1ccc2c(c1)OCO2 | None | |||
| 202478 | 204687 | 20 | 3H-GR-125743 | -97 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 219 | 3 | 1 | 2 | 3.0 | CCCN1CCC[C@H](c2cccc(O)c2)C1 | None | |||
| CHEMBL7393 | 204687 | 20 | 3H-GR-125743 | -97 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 219 | 3 | 1 | 2 | 3.0 | CCCN1CCC[C@H](c2cccc(O)c2)C1 | None | |||
| 3821 | 204718 | 17 | 3H-GR125743 | -1 | 18 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 237 | 2 | 1 | 2 | 2.9 | CNC1(c2ccccc2Cl)CCCCC1=O | None | |||
| CHEMBL742 | 204718 | 17 | 3H-GR125743 | -1 | 18 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 237 | 2 | 1 | 2 | 2.9 | CNC1(c2ccccc2Cl)CCCCC1=O | None | |||
| 4158 | 205341 | 21 | 3H-GR-125743 | -141 | 21 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 233 | 3 | 1 | 3 | 2.1 | COC(=O)C(c1ccccc1)C1CCCCN1 | None | |||
| CHEMBL1722 | 205341 | 21 | 3H-GR-125743 | -141 | 21 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 233 | 3 | 1 | 3 | 2.1 | COC(=O)C(c1ccccc1)C1CCCCN1 | None | |||
| CHEMBL796 | 205341 | 21 | 3H-GR-125743 | -141 | 21 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 233 | 3 | 1 | 3 | 2.1 | COC(=O)C(c1ccccc1)C1CCCCN1 | None | |||
| 4054 | 205501 | 72 | 3H-GR-125743 | -1 | 36 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 179 | 0 | 1 | 1 | 2.7 | CC12CC3CC(C)(C1)CC(N)(C3)C2 | None | |||
| CHEMBL1699 | 205501 | 72 | 3H-GR-125743 | -1 | 36 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 179 | 0 | 1 | 1 | 2.7 | CC12CC3CC(C)(C1)CC(N)(C3)C2 | None | |||
| CHEMBL807 | 205501 | 72 | 3H-GR-125743 | -1 | 36 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 179 | 0 | 1 | 1 | 2.7 | CC12CC3CC(C)(C1)CC(N)(C3)C2 | None | |||
| 119607 | 206203 | 113 | 3H-GR-125743 | -97 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 314 | 3 | 1 | 4 | 3.0 | Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1 | None | |||
| CHEMBL865 | 206203 | 113 | 3H-GR-125743 | -97 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 314 | 3 | 1 | 4 | 3.0 | Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1 | None | |||
| 16231 | 207509 | 57 | 3H-5HT | -7 | 17 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 229 | 1 | 5 | 6 | -1.1 | N=C(N)NC(=O)c1nc(Cl)c(N)nc1N | None | |||
| CHEMBL945 | 207509 | 57 | 3H-5HT | -7 | 17 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 229 | 1 | 5 | 6 | -1.1 | N=C(N)NC(=O)c1nc(Cl)c(N)nc1N | None | |||
| 16212426 | 215931 | 0 | 125I-CYP | -1 | 4 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 403 | 2 | 7 | 8 | -0.8 | CN1CC(=O)N=C1N.C1=C(C=C(C2=C1C(=CN2)CCN)O)O.OS(=O)(=O)O | None | |||
| 57174031 | 215940 | 0 | 3H-5HT | -1778 | 19 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | |||
| 57174031 | 215940 | 0 | 125I-CYP | -1778 | 19 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | |||
| 57174031 | 215940 | 0 | 125I-ICYP | -1778 | 19 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | |||
| 57174031 | 215940 | 0 | 3H-5HT | -1778 | 19 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | |||
| None | 215943 | 0 | 3H-5HT | -7943 | 11 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(CC)C(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C | None | |||
| 138107169 | 215952 | 0 | 125I-CYP | -19054 | 22 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O | None | |||
| 22831402 | 215952 | 0 | 125I-CYP | -19054 | 22 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O | None | |||
| 77590 | 215955 | 0 | 3H-5HT | -138 | 6 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 124 | 4 | 0 | 2 | 0.8 | COCCOCCl | None | |||
| None | 215993 | 0 | 3H-5-CT | -1 | 28 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 329 | 2 | 0 | 4 | 3.6 | CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C.Cl | None | |||
| 104911 | 216019 | 0 | 3H-GR-125743 | -38018 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 530 | 7 | 0 | 5 | 5.1 | COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl | None | |||
| None | 216020 | 0 | 3H-8-OH-DPAT | -154 | 7 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 265 | 5 | 1 | 2 | 3.5 | CCCN(CCC)C1CCC2=C(C=CC(=C2C1)O)F | None | |||
| None | 216128 | 0 | 125I-ICYP | -1 | 13 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 164 | 3 | 1 | 3 | 0.8 | C1CNC1COC2=CN=CC=C2 | None | |||
| None | 216135 | 0 | 3H-KETANSERIN | -3162 | 24 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 772 | 16 | 4 | 10 | 5.5 | CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.C(=CC(=O)O)C(=O)O | None | |||
| 25137849 | 216179 | 0 | 3H-GR-125743 | -4 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 165 | 3 | 2 | 2 | 1.3 | CC(C(C1=CC=CC=C1)O)NC | None | |||
| 71290 | 216179 | 0 | 3H-GR-125743 | -4 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 165 | 3 | 2 | 2 | 1.3 | CC(C(C1=CC=CC=C1)O)NC | None | |||
| 62857 | 216181 | 0 | 3H-5HT | -154 | 7 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 345 | 6 | 1 | 2 | 4.9 | CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F.Cl | None | |||
| None | 216254 | 0 | 3H-5HT | -8317 | 19 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 416 | 9 | 3 | 4 | 2.8 | C1=CC(=CC=C1CCNC(N)SCCCC2=CN=CN2)I | None | |||
| None | 216311 | 0 | 3H-GR-125743 | -1 | 33 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 240 | 7 | 4 | 6 | -0.8 | C(C(C(=O)O)N)SSCC(C(=O)O)N | None | |||
| None | 216312 | 0 | 3H-GR-125743 | -1 | 33 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 149 | 4 | 2 | 3 | 0.2 | CSCCC(C(=O)O)N | None | |||
| None | 216313 | 0 | 3H-GR-125743 | -1 | 33 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 135 | 3 | 3 | 3 | -0.3 | C(CS)C(C(=O)O)N | None | |||
| None | 216314 | 0 | 3H-GR-125743 | -1 | 33 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 121 | 2 | 3 | 3 | -0.7 | C(C(C(=O)O)N)S | None | |||
| None | 216316 | 0 | 3H-GR-125743 | -1 | 39 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 153 | 3 | 3 | 3 | -1.4 | C(C(C(=O)O)N)S(=O)O | None | |||
| None | 216317 | 0 | 3H-GR-125743 | -1 | 38 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 169 | 3 | 3 | 4 | -1.7 | C(C(C(=O)O)N)S(=O)(=O)O | None | |||
| None | 216318 | 0 | 3H-GR-125743 | -1 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 183 | 4 | 3 | 4 | -1.3 | C(CS(=O)(=O)O)C(C(=O)O)N | None | |||
| None | 216325 | 0 | 3H-GR-125743 | -13 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 149 | 2 | 1 | 2 | 1.2 | CC(C(=O)C1=CC=CC=C1)N | None | |||
| 1576 | 216326 | 0 | 3H-GR-125743 | -16 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 163 | 3 | 1 | 2 | 1.5 | CC(C(=O)C1=CC=CC=C1)NC | None | |||
| None | 216342 | 0 | 3H-GR-125743 | -1862 | 19 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 246 | 2 | 1 | 4 | 1.6 | CCCN1CCCC2C1CC3=CN=C(N=C3C2)N | None | |||
| 135269 | 216389 | 0 | 3H-GR-125743 | -1 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 222 | 5 | 1 | 3 | 2.5 | CCCCC(=O)OC1=CC=CC=C1C(=O)O | None | |||
| 23681059 | 216390 | 0 | 3H-GR-125743 | -1 | 28 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 230 | 3 | 1 | 2 | 3.0 | CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O | None | |||
| 5018304 | 216391 | 0 | 3H-GR-125743 | -1 | 28 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 317 | 4 | 1 | 3 | 0.0 | C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+] | None | |||
| 84003 | 216392 | 0 | 3H-GR-125743 | -1 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 376 | 6 | 5 | 7 | -0.0 | C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O | None | |||
| 123619 | 216393 | 0 | 3H-GR-125743 | -1412 | 26 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 358 | 3 | 0 | 4 | 4.2 | CC1=NC=C(C=C1)C2=NC=C(C=C2C3=CC=C(C=C3)S(=O)(=O)C)Cl | None | |||
| 119828 | 216394 | 0 | 3H-GR-125743 | -1 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 370 | 5 | 1 | 5 | 3.5 | CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C | None | |||
| None | 216395 | 0 | 3H-GR-125743 | -7 | 28 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 517 | 8 | 2 | 5 | 5.2 | CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)NCCC4=CC=C(C=C4)NC(=O)C | None | |||
| 688390 | 216485 | 0 | 125I-ICYP | -21 | 3 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 267 | 5 | 2 | 4 | 2.5 | C[C@H]([C@H](C1=C(C=CC(=C1)OC)OC)O)NC(C)(C)C | None | |||
| None | 216489 | 0 | 3H-GR-125743 | -4570 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 347 | 6 | 0 | 3 | 5.0 | CC(=O)N(CC1=CC=CC=C1OC)C2=CC=CC=C2OC3=CC=CC=C3 | None | |||
| 1150 | 3878 | 121 | 125I-CYP | -204 | 25 | Rat | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | |||
| 125 | 3878 | 121 | 125I-CYP | -204 | 25 | Rat | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | |||
| CHEMBL6640 | 3878 | 121 | 125I-CYP | -204 | 25 | Rat | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | |||
| DB08653 | 3878 | 121 | 125I-CYP | -204 | 25 | Rat | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | |||
| None | 217235 | 0 | UNDEFINED | -4 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 726 | 10 | 4 | 4 | 9.0 | C1CN(CCC1C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F)CC=CCN5CCC(CC5)C6=CNC7=C6C=C(C=C7)NC(=O)C8=CC=C(C=C8)F | None | |||
| 115 | 3791 | 80 | 125I-ICYP | 1 | 27 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 4296 | 3791 | 80 | 125I-ICYP | 1 | 27 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| CHEMBL274866 | 3791 | 80 | 125I-ICYP | 1 | 27 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 11297 | 67345 | 18 | 125I-CYP | -26 | 6 | Rat | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2cccc(O)c12 | None | |||
| 11297 | 67345 | 18 | 3H-5HT | -26 | 6 | Rat | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2cccc(O)c12 | None | |||
| CHEMBL18855 | 67345 | 18 | 125I-CYP | -26 | 6 | Rat | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2cccc(O)c12 | None | |||
| CHEMBL18855 | 67345 | 18 | 3H-5HT | -26 | 6 | Rat | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2cccc(O)c12 | None | |||
| 3033677 | 202944 | 40 | 125I-CYP | -5370 | 9 | Rat | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 411 | 5 | 1 | 5 | 3.8 | O=C(c1ccc(F)cc1)C1CCN(CCn2c(=S)[nH]c3ccccc3c2=O)CC1 | None | |||
| CHEMBL2355519 | 202944 | 40 | 125I-CYP | -5370 | 9 | Rat | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 411 | 5 | 1 | 5 | 3.8 | O=C(c1ccc(F)cc1)C1CCN(CCn2c(=S)[nH]c3ccccc3c2=O)CC1 | None | |||
| CHEMBL62919 | 202944 | 40 | 125I-CYP | -5370 | 9 | Rat | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 411 | 5 | 1 | 5 | 3.8 | O=C(c1ccc(F)cc1)C1CCN(CCn2c(=S)[nH]c3ccccc3c2=O)CC1 | None | |||
| 2995 | 204405 | 53 | 3H-5CT | -3 | 23 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | |||
| CHEMBL1696 | 204405 | 53 | 3H-5CT | -3 | 23 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | |||
| CHEMBL72 | 204405 | 53 | 3H-5CT | -3 | 23 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | |||
| None | 215956 | 0 | 125I-CYP | -141 | 6 | Rat | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 149 | 2 | 1 | 2 | 1.9 | CCC(=O)C1=CC=C(C=C1)N | None | |||
| None | 215956 | 0 | 3H-5HT | -141 | 6 | Rat | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 149 | 2 | 1 | 2 | 1.9 | CCC(=O)C1=CC=C(C=C1)N | None | |||
| None | 216278 | 0 | 3H-5CT | -12022 | 12 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 426 | 6 | 0 | 6 | 3.4 | C1CCC2C(C1)C(=O)N(C2=O)CCCCN3CCN(CC3)C4=NSC5=CC=CC=C54 | None | |||
| None | 215971 | 0 | 3H-5HT | -2344 | 15 | Rat | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 473 | 7 | 0 | 5 | 3.5 | COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br | None | |||
| 115237 | 55585 | 119 | 3H-GR-125743 | -93 | 54 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | |||
| CHEMBL1621 | 55585 | 119 | 3H-GR-125743 | -93 | 54 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | |||
| 100 | 3805 | 58 | 3H-GR-125743 | -13 | 55 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
| 2637 | 3805 | 58 | 3H-GR-125743 | -13 | 55 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
| 5452 | 3805 | 58 | 3H-GR-125743 | -13 | 55 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
| CHEMBL479 | 3805 | 58 | 3H-GR-125743 | -13 | 55 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
| DB00679 | 3805 | 58 | 3H-GR-125743 | -13 | 55 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
| 71299720 | 215951 | 0 | 125I-ICYP | -44 | 17 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 450 | 3 | 2 | 6 | 3.0 | CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4.C(=CC(=O)O)C(=O)O | None | |||
| 2337 | 3256 | 77 | 3H-GR-125743 | -26 | 62 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 50 | 3256 | 77 | 3H-GR-125743 | -26 | 62 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 5002 | 3256 | 77 | 3H-GR-125743 | -26 | 62 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| CHEMBL716 | 3256 | 77 | 3H-GR-125743 | -26 | 62 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| DB01224 | 3256 | 77 | 3H-GR-125743 | -26 | 62 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 7153 | 98020 | 77 | 125I-ICYP | -10 | 34 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | |||
| CHEMBL272942 | 98020 | 77 | 125I-ICYP | -10 | 34 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | |||
| 31101 | 729 | 40 | 125I-CYP | -48 | 36 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
| 35 | 729 | 40 | 125I-CYP | -48 | 36 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
| 403 | 729 | 40 | 125I-CYP | -48 | 36 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
| CHEMBL493 | 729 | 40 | 125I-CYP | -48 | 36 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
| DB01200 | 729 | 40 | 125I-CYP | -48 | 36 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
| 127404 | 97584 | 22 | 125I-CYP | -2 | 4 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 274 | 7 | 2 | 4 | 2.2 | CC(C)NCC(O)COc1ccccc1-n1cccc1 | None | |||
| 127404 | 97584 | 22 | 3H-5HT | -2 | 4 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 274 | 7 | 2 | 4 | 2.2 | CC(C)NCC(O)COc1ccccc1-n1cccc1 | None | |||
| CHEMBL27077 | 97584 | 22 | 125I-CYP | -2 | 4 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 274 | 7 | 2 | 4 | 2.2 | CC(C)NCC(O)COc1ccccc1-n1cccc1 | None | |||
| CHEMBL27077 | 97584 | 22 | 3H-5HT | -2 | 4 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 274 | 7 | 2 | 4 | 2.2 | CC(C)NCC(O)COc1ccccc1-n1cccc1 | None | |||
| None | 216344 | 0 | 3H-GR-125743 | -26 | 2 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 338 | 6 | 3 | 5 | 1.7 | C1CNC(=NC1)NCCCNCC2CCC3=CC=CC=C3O2.Cl | None | |||
| 1222 | 1664 | 49 | 3H-Alniditan | -134 | 33 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 3396 | 1664 | 49 | 3H-Alniditan | -134 | 33 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 85 | 1664 | 49 | 3H-Alniditan | -134 | 33 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| CHEMBL46516 | 1664 | 49 | 3H-Alniditan | -134 | 33 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| DB04842 | 1664 | 49 | 3H-Alniditan | -134 | 33 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 115 | 3791 | 80 | 3H-5HT | -2 | 27 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 4296 | 3791 | 80 | 3H-5HT | -2 | 27 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| CHEMBL274866 | 3791 | 80 | 3H-5HT | -2 | 27 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 71299720 | 215951 | 0 | 125I-CYP | -44 | 17 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 450 | 3 | 2 | 6 | 3.0 | CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4.C(=CC(=O)O)C(=O)O | None | |||
| 71299720 | 215951 | 0 | 3H-5HT | -44 | 17 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 450 | 3 | 2 | 6 | 3.0 | CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4.C(=CC(=O)O)C(=O)O | None | |||
| 1809 | 134 | 32 | 3H-GR-125743 | -15 | 36 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-GR-125743 | -15 | 36 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-GR-125743 | -15 | 36 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 115237 | 55585 | 119 | 3H-Alniditan | -93 | 54 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | |||
| CHEMBL1621 | 55585 | 119 | 3H-Alniditan | -93 | 54 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | |||
| 1342 | 35 | 49 | 3H-5HT | -4 | 19 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| 3 | 35 | 49 | 3H-5HT | -4 | 19 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| CHEMBL277120 | 35 | 49 | 3H-5HT | -4 | 19 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| None | 215946 | 0 | 3H-5HT | -8 | 24 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 346 | 5 | 4 | 4 | 2.5 | COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O | None | |||
| None | 215946 | 0 | 3H-5HT | -8 | 24 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 346 | 5 | 4 | 4 | 2.5 | COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O | None | |||
| None | 216343 | 0 | 3H-GR-125743 | -1 | 2 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 228 | 2 | 1 | 3 | 2.6 | C1CNCCC1SC2=NC(=CC=C2)Cl | None | |||
| 4106 | 2502 | 22 | 125I-ICYP | -102 | 34 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 5358812 | 2502 | 22 | 125I-ICYP | -102 | 34 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 89 | 2502 | 22 | 125I-ICYP | -102 | 34 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| CHEMBL93240 | 2502 | 22 | 125I-ICYP | -102 | 34 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 1220 | 187 | 55 | 3H-5HT | -208 | 44 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 31 | 187 | 55 | 3H-5HT | -208 | 44 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 7 | 187 | 55 | 3H-5HT | -208 | 44 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| CHEMBL56 | 187 | 55 | 3H-5HT | -208 | 44 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 135398737 | 958 | 93 | 3H-5HT | -691 | 89 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 38 | 958 | 93 | 3H-5HT | -691 | 89 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 722 | 958 | 93 | 3H-5HT | -691 | 89 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| CHEMBL42 | 958 | 93 | 3H-5HT | -691 | 89 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| DB00363 | 958 | 93 | 3H-5HT | -691 | 89 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 2176 | 3127 | 68 | 3H-8-OH-DPAT | -1737 | 27 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 4828 | 3127 | 68 | 3H-8-OH-DPAT | -1737 | 27 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 91 | 3127 | 68 | 3H-8-OH-DPAT | -1737 | 27 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| CHEMBL500 | 3127 | 68 | 3H-8-OH-DPAT | -1737 | 27 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| DB00960 | 3127 | 68 | 3H-8-OH-DPAT | -1737 | 27 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 10060720 | 205672 | 14 | 3H-5HT | -46 | 4 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 251 | 7 | 1 | 3 | 2.9 | CCCCc1cc(OC)c(CC(C)N)cc1OC | None | |||
| CHEMBL8214 | 205672 | 14 | 3H-5HT | -46 | 4 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 251 | 7 | 1 | 3 | 2.9 | CCCCc1cc(OC)c(CC(C)N)cc1OC | None | |||
| None | 216450 | 0 | UNDEFINED | -8 | 28 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 322 | 5 | 2 | 3 | 4.1 | CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl | None | |||
| 24881618 | 188787 | 0 | UNDEFINED | -125 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 798 | 16 | 4 | 4 | 11.2 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | None | |||
| CHEMBL505750 | 188787 | 0 | UNDEFINED | -125 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 798 | 16 | 4 | 4 | 11.2 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | None | |||
| 24881619 | 189038 | 0 | UNDEFINED | -9 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 826 | 18 | 4 | 4 | 12.0 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | None | |||
| CHEMBL509314 | 189038 | 0 | UNDEFINED | -9 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 826 | 18 | 4 | 4 | 12.0 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | None | |||
| 11957541 | 1459 | 40 | 3H-5HT | -288 | 16 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | None | |||
| 1229 | 1459 | 40 | 3H-5HT | -288 | 16 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | None | |||
| 147 | 1459 | 40 | 3H-5HT | -288 | 16 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | None | |||
| 170617 | 1459 | 40 | 3H-5HT | -288 | 16 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | None | |||
| CHEMBL6616 | 1459 | 40 | 3H-5HT | -288 | 16 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | None | |||
| 133 | 2496 | 52 | 125I-ICYP | -40 | 42 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 1723 | 2496 | 52 | 125I-ICYP | -40 | 42 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 28693 | 2496 | 52 | 125I-ICYP | -40 | 42 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| CHEMBL19215 | 2496 | 52 | 125I-ICYP | -40 | 42 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| DB13520 | 2496 | 52 | 125I-ICYP | -40 | 42 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 206 | 2493 | 16 | 3H-5HT | -549 | 25 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | None | |||
| 68848 | 2493 | 16 | 3H-5HT | -549 | 25 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | None | |||
| CHEMBL12314 | 2493 | 16 | 3H-5HT | -549 | 25 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | None | |||
| 123707 | 216484 | 0 | 125I-ICYP | -295 | 3 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 416 | 9 | 3 | 6 | 1.8 | CC1=C(C=C(C=C1)C(CNCCOC2=CC=CC=C2OC)O)S(=O)(=O)N.Cl | None | |||
| 122 | 1437 | 9 | 3H-5HT | -5 | 11 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 287 | 8 | 2 | 2 | 2.9 | CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 156314 | 1437 | 9 | 3H-5HT | -5 | 11 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 287 | 8 | 2 | 2 | 2.9 | CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL1332062 | 1437 | 9 | 3H-5HT | -5 | 11 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 287 | 8 | 2 | 2 | 2.9 | CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 2865 | 4143 | 73 | 3H-5HT | -263 | 53 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| 59 | 4143 | 73 | 3H-5HT | -263 | 53 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| 60854 | 4143 | 73 | 3H-5HT | -263 | 53 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| CHEMBL708 | 4143 | 73 | 3H-5HT | -263 | 53 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| DB00246 | 4143 | 73 | 3H-5HT | -263 | 53 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| 135398737 | 958 | 93 | 3H-5HT | -691 | 89 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 38 | 958 | 93 | 3H-5HT | -691 | 89 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 722 | 958 | 93 | 3H-5HT | -691 | 89 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| CHEMBL42 | 958 | 93 | 3H-5HT | -691 | 89 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| DB00363 | 958 | 93 | 3H-5HT | -691 | 89 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 2176 | 3127 | 68 | 125I-ICYP | -741 | 27 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 4828 | 3127 | 68 | 125I-ICYP | -741 | 27 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 91 | 3127 | 68 | 125I-ICYP | -741 | 27 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| CHEMBL500 | 3127 | 68 | 125I-ICYP | -741 | 27 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| DB00960 | 3127 | 68 | 125I-ICYP | -741 | 27 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 115 | 3791 | 80 | 125I-CYP | 1 | 27 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 115 | 3791 | 80 | 3H-5HT | 1 | 27 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 4296 | 3791 | 80 | 125I-CYP | 1 | 27 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 4296 | 3791 | 80 | 3H-5HT | 1 | 27 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| CHEMBL274866 | 3791 | 80 | 125I-CYP | 1 | 27 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| CHEMBL274866 | 3791 | 80 | 3H-5HT | 1 | 27 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 2389 | 3331 | 118 | 3H-5HT | -6456 | 67 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 5073 | 3331 | 118 | 3H-5HT | -6456 | 67 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 96 | 3331 | 118 | 3H-5HT | -6456 | 67 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| CHEMBL85 | 3331 | 118 | 3H-5HT | -6456 | 67 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| DB00734 | 3331 | 118 | 3H-5HT | -6456 | 67 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 1346 | 83 | 117 | 125I-ICYP | -40 | 9 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 192 | 2 | 1 | 3 | 1.1 | COc1ccccc1N1CCNCC1 | None | |||
| 280 | 83 | 117 | 125I-ICYP | -40 | 9 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 192 | 2 | 1 | 3 | 1.1 | COc1ccccc1N1CCNCC1 | None | |||
| 9899402 | 83 | 117 | 125I-ICYP | -40 | 9 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 192 | 2 | 1 | 3 | 1.1 | COc1ccccc1N1CCNCC1 | None | |||
| CHEMBL9666 | 83 | 117 | 125I-ICYP | -40 | 9 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 192 | 2 | 1 | 3 | 1.1 | COc1ccccc1N1CCNCC1 | None | |||
| 135398745 | 2914 | 112 | 3H-5HT | -162 | 65 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| 47 | 2914 | 112 | 3H-5HT | -162 | 65 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| CHEMBL715 | 2914 | 112 | 3H-5HT | -162 | 65 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| DB00334 | 2914 | 112 | 3H-5HT | -162 | 65 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| 5 | 139 | 72 | 125I-ICYP | -13 | 54 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 125I-ICYP | -13 | 54 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 125I-ICYP | -13 | 54 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 125I-ICYP | -13 | 54 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 180 | 401 | 56 | 3H-MESULERGINE | -281 | 40 | Cat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | |||
| 200 | 401 | 56 | 3H-MESULERGINE | -281 | 40 | Cat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | |||
| 2160 | 401 | 56 | 3H-MESULERGINE | -281 | 40 | Cat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | |||
| CHEMBL629 | 401 | 56 | 3H-MESULERGINE | -281 | 40 | Cat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | |||
| DB00321 | 401 | 56 | 3H-MESULERGINE | -281 | 40 | Cat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | |||
| 71299720 | 215951 | 0 | 3H-5HT | -44 | 17 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 450 | 3 | 2 | 6 | 3.0 | CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4.C(=CC(=O)O)C(=O)O | None | |||
| 127 | 3126 | 52 | 3H-GR-125743 | -3388 | 15 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 688095 | 3126 | 52 | 3H-GR-125743 | -3388 | 15 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| CHEMBL117405 | 3126 | 52 | 3H-GR-125743 | -3388 | 15 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 2726 | 919 | 68 | 3H-GR-125743 | -54 | 72 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 2726 | 919 | 68 | 3H-5HT | -147 | 72 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 621 | 919 | 68 | 3H-GR-125743 | -54 | 72 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 621 | 919 | 68 | 3H-5HT | -147 | 72 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 83 | 919 | 68 | 3H-GR-125743 | -54 | 72 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 83 | 919 | 68 | 3H-5HT | -147 | 72 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| CHEMBL71 | 919 | 68 | 3H-GR-125743 | -54 | 72 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| CHEMBL71 | 919 | 68 | 3H-5HT | -147 | 72 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| DB00477 | 919 | 68 | 3H-GR-125743 | -54 | 72 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| DB00477 | 919 | 68 | 3H-5HT | -147 | 72 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 107 | 141 | 121 | 3H-5HT | -30 | 30 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1833 | 141 | 121 | 3H-5HT | -30 | 30 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| CHEMBL8165 | 141 | 121 | 3H-5HT | -30 | 30 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 5 | 139 | 72 | 3H-5HT | -11 | 54 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5 | 139 | 72 | 125I-ICYP | -13 | 54 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-5HT | -11 | 54 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 125I-ICYP | -13 | 54 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-5HT | -11 | 54 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 125I-ICYP | -13 | 54 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-5HT | -11 | 54 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 125I-ICYP | -13 | 54 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 133 | 2496 | 52 | 3H-GR-125743 | -40 | 42 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 1723 | 2496 | 52 | 3H-GR-125743 | -40 | 42 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 28693 | 2496 | 52 | 3H-GR-125743 | -40 | 42 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| CHEMBL19215 | 2496 | 52 | 3H-GR-125743 | -40 | 42 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| DB13520 | 2496 | 52 | 3H-GR-125743 | -40 | 42 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 102 | 4127 | 48 | 3H-5HT | -2691 | 49 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 3659 | 4127 | 48 | 3H-5HT | -2691 | 49 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 8969 | 4127 | 48 | 3H-5HT | -2691 | 49 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| CHEMBL15245 | 4127 | 48 | 3H-5HT | -2691 | 49 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| DB01392 | 4127 | 48 | 3H-5HT | -2691 | 49 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 2220 | 3134 | 82 | 3H-5HT | -1023 | 14 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 295 | 0 | 0 | 2 | 4.4 | CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 | None | |||
| 27400 | 3134 | 82 | 3H-5HT | -1023 | 14 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 295 | 0 | 0 | 2 | 4.4 | CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 | None | |||
| 93 | 3134 | 82 | 3H-5HT | -1023 | 14 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 295 | 0 | 0 | 2 | 4.4 | CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 | None | |||
| CHEMBL294951 | 3134 | 82 | 3H-5HT | -1023 | 14 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 295 | 0 | 0 | 2 | 4.4 | CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 | None | |||
| DB06153 | 3134 | 82 | 3H-5HT | -1023 | 14 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 295 | 0 | 0 | 2 | 4.4 | CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 | None | |||
| 1621 | 2429 | 17 | 125I-CYP | -97 | 45 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 17 | 2429 | 17 | 125I-CYP | -97 | 45 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 5761 | 2429 | 17 | 125I-CYP | -97 | 45 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| CHEMBL263881 | 2429 | 17 | 125I-CYP | -97 | 45 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| DB04829 | 2429 | 17 | 125I-CYP | -97 | 45 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 11954259 | 215979 | 0 | 3H-GR-125743 | -501 | 43 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C | None | |||
| 2176 | 3127 | 68 | 125I-ICYP | -741 | 27 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 4828 | 3127 | 68 | 125I-ICYP | -741 | 27 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 91 | 3127 | 68 | 125I-ICYP | -741 | 27 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| CHEMBL500 | 3127 | 68 | 125I-ICYP | -741 | 27 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| DB00960 | 3127 | 68 | 125I-ICYP | -741 | 27 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 102 | 4127 | 48 | 3H-5HT | -2691 | 49 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 3659 | 4127 | 48 | 3H-5HT | -2691 | 49 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 8969 | 4127 | 48 | 3H-5HT | -2691 | 49 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| CHEMBL15245 | 4127 | 48 | 3H-5HT | -2691 | 49 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| DB01392 | 4127 | 48 | 3H-5HT | -2691 | 49 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 134 | 2514 | 24 | 125I-CYP | -251 | 67 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1775 | 2514 | 24 | 125I-CYP | -251 | 67 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 9681 | 2514 | 24 | 125I-CYP | -251 | 67 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| CHEMBL1065 | 2514 | 24 | 125I-CYP | -251 | 67 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| DB00247 | 2514 | 24 | 125I-CYP | -251 | 67 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1342 | 35 | 49 | 125I-CYP | -50 | 19 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| 1342 | 35 | 49 | 3H-5HT | -50 | 19 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| 3 | 35 | 49 | 125I-CYP | -50 | 19 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| 3 | 35 | 49 | 3H-5HT | -50 | 19 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| CHEMBL277120 | 35 | 49 | 125I-CYP | -50 | 19 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| CHEMBL277120 | 35 | 49 | 3H-5HT | -50 | 19 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| 102 | 4127 | 48 | 35S-GTPGammaS | -64 | 49 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 102 | 4127 | 48 | 3H-GR-125743 | -64 | 49 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 3659 | 4127 | 48 | 35S-GTPGammaS | -64 | 49 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 3659 | 4127 | 48 | 3H-GR-125743 | -64 | 49 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 8969 | 4127 | 48 | 35S-GTPGammaS | -64 | 49 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 8969 | 4127 | 48 | 3H-GR-125743 | -64 | 49 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| CHEMBL15245 | 4127 | 48 | 35S-GTPGammaS | -64 | 49 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| CHEMBL15245 | 4127 | 48 | 3H-GR-125743 | -64 | 49 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| DB01392 | 4127 | 48 | 35S-GTPGammaS | -64 | 49 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| DB01392 | 4127 | 48 | 3H-GR-125743 | -64 | 49 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 1588 | 2325 | 27 | 3H-5-CT | -42 | 44 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 28864 | 2325 | 27 | 3H-5-CT | -42 | 44 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 43 | 2325 | 27 | 3H-5-CT | -42 | 44 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| CHEMBL157138 | 2325 | 27 | 3H-5-CT | -42 | 44 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| DB00589 | 2325 | 27 | 3H-5-CT | -42 | 44 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 24881201 | 186849 | 0 | UNDEFINED | -4 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 526 | 6 | 4 | 4 | 5.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)CC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | None | |||
| CHEMBL489453 | 186849 | 0 | UNDEFINED | -4 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 526 | 6 | 4 | 4 | 5.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)CC(=O)Nc4ccc5[nH]cc(C6CCN(C)CC6)c5c4)cc23)CC1 | None | |||
| 138107169 | 215952 | 0 | 3H-5HT | -141 | 22 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O | None | |||
| 22831402 | 215952 | 0 | 3H-5HT | -141 | 22 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O | None | |||
| 4106 | 2502 | 22 | 3H-5HT | -11 | 34 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 5358812 | 2502 | 22 | 3H-5HT | -11 | 34 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 89 | 2502 | 22 | 3H-5HT | -11 | 34 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| CHEMBL93240 | 2502 | 22 | 3H-5HT | -11 | 34 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 2181 | 3128 | 46 | 3H-Alniditan | -70 | 35 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| 4830 | 3128 | 46 | 3H-Alniditan | -70 | 35 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| 92 | 3128 | 46 | 3H-Alniditan | -70 | 35 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| CHEMBL440294 | 3128 | 46 | 3H-Alniditan | -70 | 35 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| DB09286 | 3128 | 46 | 3H-Alniditan | -70 | 35 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| 277 | 1301 | 62 | 3H-5CT | -1905 | 50 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | |||
| 2913 | 1301 | 62 | 3H-5CT | -1905 | 50 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | |||
| 765 | 1301 | 62 | 3H-5CT | -1905 | 50 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | |||
| CHEMBL516 | 1301 | 62 | 3H-5CT | -1905 | 50 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | |||
| DB00434 | 1301 | 62 | 3H-5CT | -1905 | 50 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | |||
| 134 | 2514 | 24 | 3H-5HT | -14 | 67 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1775 | 2514 | 24 | 3H-5HT | -14 | 67 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 9681 | 2514 | 24 | 3H-5HT | -14 | 67 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| CHEMBL1065 | 2514 | 24 | 3H-5HT | -14 | 67 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| DB00247 | 2514 | 24 | 3H-5HT | -14 | 67 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 7153 | 98020 | 77 | 3H-5CT | -11 | 34 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | |||
| CHEMBL272942 | 98020 | 77 | 3H-5CT | -11 | 34 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | |||
| 45266826 | 217691 | 0 | [3H] 5-CT | -2 | 8 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 177 | 3 | 1 | 2 | 1.8 | CC1=CC=C(C=C1)C(=O)C(C)NC | None | |||
| 133 | 2496 | 52 | 125I-ICYP | -40 | 42 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 1723 | 2496 | 52 | 125I-ICYP | -40 | 42 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 28693 | 2496 | 52 | 125I-ICYP | -40 | 42 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| CHEMBL19215 | 2496 | 52 | 125I-ICYP | -40 | 42 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| DB13520 | 2496 | 52 | 125I-ICYP | -40 | 42 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 1353 | 1911 | 93 | 3H-GR-125743 | -66 | 83 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 3559 | 1911 | 93 | 3H-GR-125743 | -66 | 83 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 86 | 1911 | 93 | 3H-GR-125743 | -66 | 83 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| CHEMBL54 | 1911 | 93 | 3H-GR-125743 | -66 | 83 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| DB00502 | 1911 | 93 | 3H-GR-125743 | -66 | 83 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 133 | 2496 | 52 | 125I-ICYP | -40 | 42 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 1723 | 2496 | 52 | 125I-ICYP | -40 | 42 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 28693 | 2496 | 52 | 125I-ICYP | -40 | 42 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| CHEMBL19215 | 2496 | 52 | 125I-ICYP | -40 | 42 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| DB13520 | 2496 | 52 | 125I-ICYP | -40 | 42 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 165193 | 215945 | 0 | 3H-5HT | -154 | 30 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 62882 | 215945 | 0 | 3H-5HT | -154 | 30 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 66366 | 215945 | 0 | 3H-5HT | -154 | 30 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 2176 | 3127 | 68 | 125I-CYP | -741 | 27 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 4828 | 3127 | 68 | 125I-CYP | -741 | 27 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 91 | 3127 | 68 | 125I-CYP | -741 | 27 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| CHEMBL500 | 3127 | 68 | 125I-CYP | -741 | 27 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| DB00960 | 3127 | 68 | 125I-CYP | -741 | 27 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 1621 | 2429 | 17 | 3H-5HT | -97 | 45 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 17 | 2429 | 17 | 3H-5HT | -97 | 45 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 5761 | 2429 | 17 | 3H-5HT | -97 | 45 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| CHEMBL263881 | 2429 | 17 | 3H-5HT | -97 | 45 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| DB04829 | 2429 | 17 | 3H-5HT | -97 | 45 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 2543 | 3707 | 68 | 3H-GR-125743 | -48 | 32 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | 3H-GR-125743 | -48 | 32 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | 3H-GR-125743 | -48 | 32 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | 3H-GR-125743 | -48 | 32 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | 3H-GR-125743 | -48 | 32 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 4631 | 194972 | 29 | 125I-ICYP | -22 | 7 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 265 | 9 | 2 | 4 | 2.0 | C=CCOc1ccccc1OCC(O)CNC(C)C | None | |||
| CHEMBL546 | 194972 | 29 | 125I-ICYP | -22 | 7 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 265 | 9 | 2 | 4 | 2.0 | C=CCOc1ccccc1OCC(O)CNC(C)C | None | |||
| 132787 | 3430 | 45 | 3H-5HT | -1000 | 6 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 336 | 2 | 0 | 4 | 2.7 | C1COc2c(O1)cccc2N1CCN(CC1)C1Cc2c(C1)cccc2 | None | |||
| 26 | 3430 | 45 | 3H-5HT | -1000 | 6 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 336 | 2 | 0 | 4 | 2.7 | C1COc2c(O1)cccc2N1CCN(CC1)C1Cc2c(C1)cccc2 | None | |||
| 32 | 3430 | 45 | 3H-5HT | -1000 | 6 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 336 | 2 | 0 | 4 | 2.7 | C1COc2c(O1)cccc2N1CCN(CC1)C1Cc2c(C1)cccc2 | None | |||
| CHEMBL49247 | 3430 | 45 | 3H-5HT | -1000 | 6 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 336 | 2 | 0 | 4 | 2.7 | C1COc2c(O1)cccc2N1CCN(CC1)C1Cc2c(C1)cccc2 | None | |||
| 179 | 400 | 115 | 3H-5CT | -43 | 49 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| 2159 | 400 | 115 | 3H-5CT | -43 | 49 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| 963 | 400 | 115 | 3H-5CT | -43 | 49 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| CHEMBL243712 | 400 | 115 | 3H-5CT | -43 | 49 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| DB06288 | 400 | 115 | 3H-5CT | -43 | 49 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| 24882268 | 172557 | 0 | UNDEFINED | -11 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 788 | 15 | 4 | 6 | 8.5 | O=C(Nc1ccc2[nH]cc(C3CCN(CCOCCOCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | None | |||
| CHEMBL448555 | 172557 | 0 | UNDEFINED | -11 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 788 | 15 | 4 | 6 | 8.5 | O=C(Nc1ccc2[nH]cc(C3CCN(CCOCCOCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | None | |||
| None | 215938 | 0 | 3H-5HT | -3 | 21 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 583 | 4 | 3 | 6 | 2.1 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C | None | |||
| 1588 | 2325 | 27 | 3H-GR-125743 | -42 | 44 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 28864 | 2325 | 27 | 3H-GR-125743 | -42 | 44 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 43 | 2325 | 27 | 3H-GR-125743 | -42 | 44 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| CHEMBL157138 | 2325 | 27 | 3H-GR-125743 | -42 | 44 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| DB00589 | 2325 | 27 | 3H-GR-125743 | -42 | 44 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 2605 | 3783 | 30 | 3H-5HT | -7 | 10 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 295 | 5 | 2 | 4 | 2.9 | OC(COc1cccc2c1SCCC2)CNC(C)(C)C | None | |||
| 36920 | 3783 | 30 | 3H-5HT | -7 | 10 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 295 | 5 | 2 | 4 | 2.9 | OC(COc1cccc2c1SCCC2)CNC(C)(C)C | None | |||
| 571 | 3783 | 30 | 3H-5HT | -7 | 10 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 295 | 5 | 2 | 4 | 2.9 | OC(COc1cccc2c1SCCC2)CNC(C)(C)C | None | |||
| CHEMBL434200 | 3783 | 30 | 3H-5HT | -7 | 10 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 295 | 5 | 2 | 4 | 2.9 | OC(COc1cccc2c1SCCC2)CNC(C)(C)C | None | |||
| DB13775 | 3783 | 30 | 3H-5HT | -7 | 10 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 295 | 5 | 2 | 4 | 2.9 | OC(COc1cccc2c1SCCC2)CNC(C)(C)C | None | |||
| 134 | 2514 | 24 | 125I-ICYP | -251 | 67 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1775 | 2514 | 24 | 125I-ICYP | -251 | 67 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 9681 | 2514 | 24 | 125I-ICYP | -251 | 67 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| CHEMBL1065 | 2514 | 24 | 125I-ICYP | -251 | 67 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| DB00247 | 2514 | 24 | 125I-ICYP | -251 | 67 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 3337 | 206367 | 27 | 3H-GR-125743 | -74 | 40 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
| 65801 | 206367 | 27 | 3H-GR-125743 | -74 | 40 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
| 66264 | 206367 | 27 | 3H-GR-125743 | -74 | 40 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
| 91452 | 206367 | 27 | 3H-GR-125743 | -74 | 40 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
| CHEMBL87493 | 206367 | 27 | 3H-GR-125743 | -74 | 40 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
| 164 | 1460 | 19 | 3H-5HT | -89 | 10 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 209 | 4 | 1 | 3 | 1.9 | COc1cc(C)c(cc1CC(N)C)OC | None | |||
| 85875 | 1460 | 19 | 3H-5HT | -89 | 10 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 209 | 4 | 1 | 3 | 1.9 | COc1cc(C)c(cc1CC(N)C)OC | None | |||
| CHEMBL8600 | 1460 | 19 | 3H-5HT | -89 | 10 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 209 | 4 | 1 | 3 | 1.9 | COc1cc(C)c(cc1CC(N)C)OC | None | |||
| DB01528 | 1460 | 19 | 3H-5HT | -89 | 10 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 209 | 4 | 1 | 3 | 1.9 | COc1cc(C)c(cc1CC(N)C)OC | None | |||
| 134 | 2514 | 24 | 3H-GR-125743 | -158 | 67 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1775 | 2514 | 24 | 3H-GR-125743 | -158 | 67 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 9681 | 2514 | 24 | 3H-GR-125743 | -158 | 67 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| CHEMBL1065 | 2514 | 24 | 3H-GR-125743 | -158 | 67 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| DB00247 | 2514 | 24 | 3H-GR-125743 | -158 | 67 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1809 | 134 | 32 | 3H-5HT | -32 | 36 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-5HT | -32 | 36 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-5HT | -32 | 36 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 102 | 4127 | 48 | 3H-5-CT | -64 | 49 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 3659 | 4127 | 48 | 3H-5-CT | -64 | 49 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 8969 | 4127 | 48 | 3H-5-CT | -64 | 49 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| CHEMBL15245 | 4127 | 48 | 3H-5-CT | -64 | 49 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| DB01392 | 4127 | 48 | 3H-5-CT | -64 | 49 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 3337 | 206367 | 27 | 3H-GR-125743 | -74 | 40 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
| 65801 | 206367 | 27 | 3H-GR-125743 | -74 | 40 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
| 66264 | 206367 | 27 | 3H-GR-125743 | -74 | 40 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
| 91452 | 206367 | 27 | 3H-GR-125743 | -74 | 40 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
| CHEMBL87493 | 206367 | 27 | 3H-GR-125743 | -74 | 40 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
| 173 | 3262 | 95 | 3H-5HT | -2 | 23 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | None | |||
| 5011 | 3262 | 95 | 3H-5HT | -2 | 23 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | None | |||
| CHEMBL18772 | 3262 | 95 | 3H-5HT | -2 | 23 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | None | |||
| 1524 | 2181 | 96 | 125I-CYP | -512 | 52 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 197 | 2181 | 96 | 125I-CYP | -512 | 52 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 3822 | 2181 | 96 | 125I-CYP | -512 | 52 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 88 | 2181 | 96 | 125I-CYP | -512 | 52 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| CHEMBL51 | 2181 | 96 | 125I-CYP | -512 | 52 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| DB12465 | 2181 | 96 | 125I-CYP | -512 | 52 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 1531 | 2266 | 69 | 125I-ICYP | -676 | 16 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 328 | 8 | 5 | 4 | 2.9 | CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O | None | |||
| 3869 | 2266 | 69 | 125I-ICYP | -676 | 16 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 328 | 8 | 5 | 4 | 2.9 | CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O | None | |||
| 7207 | 2266 | 69 | 125I-ICYP | -676 | 16 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 328 | 8 | 5 | 4 | 2.9 | CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O | None | |||
| CHEMBL429 | 2266 | 69 | 125I-ICYP | -676 | 16 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 328 | 8 | 5 | 4 | 2.9 | CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O | None | |||
| DB00598 | 2266 | 69 | 125I-ICYP | -676 | 16 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 328 | 8 | 5 | 4 | 2.9 | CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O | None | |||
| 2543 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 11954224 | 215953 | 0 | 125I-CYP | -12 | 58 | Rat | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
| 71299720 | 215951 | 0 | 3H-5HT | 1 | 17 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 450 | 3 | 2 | 6 | 3.0 | CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4.C(=CC(=O)O)C(=O)O | None | |||
| 5 | 139 | 72 | 3H-GR-125743 | -5 | 54 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-GR-125743 | -5 | 54 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-GR-125743 | -5 | 54 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-GR-125743 | -5 | 54 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| None | 215938 | 0 | 3H-5HT | -3 | 21 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 583 | 4 | 3 | 6 | 2.1 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C | None | |||
| 134 | 2514 | 24 | 3H-GR-125743 | -14 | 67 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 134 | 2514 | 24 | 3H-GR125743 | -14 | 67 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1775 | 2514 | 24 | 3H-GR-125743 | -14 | 67 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1775 | 2514 | 24 | 3H-GR125743 | -14 | 67 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 9681 | 2514 | 24 | 3H-GR-125743 | -14 | 67 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 9681 | 2514 | 24 | 3H-GR125743 | -14 | 67 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| CHEMBL1065 | 2514 | 24 | 3H-GR-125743 | -14 | 67 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| CHEMBL1065 | 2514 | 24 | 3H-GR125743 | -14 | 67 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| DB00247 | 2514 | 24 | 3H-GR-125743 | -14 | 67 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| DB00247 | 2514 | 24 | 3H-GR125743 | -14 | 67 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 5 | 139 | 72 | 3H-5CT | -5 | 54 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-5CT | -5 | 54 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-5CT | -5 | 54 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-5CT | -5 | 54 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 132 | 1275 | 13 | 3H-5HT | -125 | 15 | Mouse | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| 155346 | 1275 | 13 | 3H-5HT | -125 | 15 | Mouse | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| CHEMBL378501 | 1275 | 13 | 3H-5HT | -125 | 15 | Mouse | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| 124 | 2981 | 47 | 3H-5HT | -2 | 33 | Rat | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| 2032 | 2981 | 47 | 3H-5HT | -2 | 33 | Rat | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| 4636 | 2981 | 47 | 3H-5HT | -2 | 33 | Rat | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| CHEMBL762 | 2981 | 47 | 3H-5HT | -2 | 33 | Rat | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| DB00935 | 2981 | 47 | 3H-5HT | -2 | 33 | Rat | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| None | 215946 | 0 | 3H-5HT | 2 | 24 | Rat | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 346 | 5 | 4 | 4 | 2.5 | COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O | None | |||
| 5 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| None | 215938 | 0 | 3H-GR-125743 | -18 | 21 | Rat | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 583 | 4 | 3 | 6 | 2.1 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C | None | |||
| 132 | 1275 | 13 | 125I-ICYP | -54 | 15 | Rat | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| 155346 | 1275 | 13 | 125I-ICYP | -54 | 15 | Rat | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| CHEMBL378501 | 1275 | 13 | 125I-ICYP | -54 | 15 | Rat | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| 71299720 | 215951 | 0 | 3H-5HT | 1 | 17 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 450 | 3 | 2 | 6 | 3.0 | CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4.C(=CC(=O)O)C(=O)O | None | |||
| 152662 | 215957 | 0 | 125I-CYP | 109 | 7 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 276 | 5 | 3 | 3 | 2.6 | CC1=CC2=C(N1)C=CC=C2OCC(CNC(C)(C)C)O | None | |||
| None | 215938 | 0 | 125I-ICYP | -18 | 21 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 583 | 4 | 3 | 6 | 2.1 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C | None | |||
| 2389 | 3331 | 118 | 3H-Alniditan | -93 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 5073 | 3331 | 118 | 3H-Alniditan | -93 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 96 | 3331 | 118 | 3H-Alniditan | -93 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| CHEMBL85 | 3331 | 118 | 3H-Alniditan | -93 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| DB00734 | 3331 | 118 | 3H-Alniditan | -93 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 173 | 3262 | 95 | 3H-5HT | -2 | 23 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | None | |||
| 5011 | 3262 | 95 | 3H-5HT | -2 | 23 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | None | |||
| CHEMBL18772 | 3262 | 95 | 3H-5HT | -2 | 23 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | None | |||
| 21163 | 215930 | 0 | 3H-5HT | -4 | 5 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 192 | 2 | 4 | 3 | 1.1 | C1=C2C(=CC(=C1O)O)NC=C2CCN | None | |||
| 2337 | 3256 | 77 | 3H-Alniditan | -26 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 50 | 3256 | 77 | 3H-Alniditan | -26 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 5002 | 3256 | 77 | 3H-Alniditan | -26 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| CHEMBL716 | 3256 | 77 | 3H-Alniditan | -26 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| DB01224 | 3256 | 77 | 3H-Alniditan | -26 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 164 | 1460 | 19 | 3H-5HT | -89 | 10 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 209 | 4 | 1 | 3 | 1.9 | COc1cc(C)c(cc1CC(N)C)OC | None | |||
| 85875 | 1460 | 19 | 3H-5HT | -89 | 10 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 209 | 4 | 1 | 3 | 1.9 | COc1cc(C)c(cc1CC(N)C)OC | None | |||
| CHEMBL8600 | 1460 | 19 | 3H-5HT | -89 | 10 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 209 | 4 | 1 | 3 | 1.9 | COc1cc(C)c(cc1CC(N)C)OC | None | |||
| DB01528 | 1460 | 19 | 3H-5HT | -89 | 10 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 209 | 4 | 1 | 3 | 1.9 | COc1cc(C)c(cc1CC(N)C)OC | None | |||
| None | 216322 | 0 | 3H-5HT | -69 | 6 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 390 | 4 | 1 | 4 | 3.2 | C1CN(CCN1CCN2C3=CC=CC=C3NC2=O)C4=CC=C(C=C4)C(F)(F)F | None | |||
| 132 | 1275 | 13 | 3H-5HT | -602 | 15 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| 155346 | 1275 | 13 | 3H-5HT | -602 | 15 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| CHEMBL378501 | 1275 | 13 | 3H-5HT | -602 | 15 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| 135398737 | 958 | 93 | 3H-5CT | -151 | 89 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 38 | 958 | 93 | 3H-5CT | -151 | 89 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 722 | 958 | 93 | 3H-5CT | -151 | 89 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| CHEMBL42 | 958 | 93 | 3H-5CT | -151 | 89 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| DB00363 | 958 | 93 | 3H-5CT | -151 | 89 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 7153 | 98020 | 77 | 3H-5HT | -11 | 34 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | |||
| CHEMBL272942 | 98020 | 77 | 3H-5HT | -11 | 34 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | |||
| 132 | 1275 | 13 | 3H-5HT | -602 | 15 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| 155346 | 1275 | 13 | 3H-5HT | -602 | 15 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| CHEMBL378501 | 1275 | 13 | 3H-5HT | -602 | 15 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| 102 | 4127 | 48 | 3H-5HT | -64 | 49 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 3659 | 4127 | 48 | 3H-5HT | -64 | 49 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 8969 | 4127 | 48 | 3H-5HT | -64 | 49 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| CHEMBL15245 | 4127 | 48 | 3H-5HT | -64 | 49 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| DB01392 | 4127 | 48 | 3H-5HT | -64 | 49 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 141 | 1427 | 35 | 125I-CYP | -25 | 22 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | None | |||
| 6089 | 1427 | 35 | 125I-CYP | -25 | 22 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | None | |||
| CHEMBL12420 | 1427 | 35 | 125I-CYP | -25 | 22 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | None | |||
| DB01488 | 1427 | 35 | 125I-CYP | -25 | 22 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | None | |||
| 173 | 3262 | 95 | 125I-ICYP | -2 | 23 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | None | |||
| 5011 | 3262 | 95 | 125I-ICYP | -2 | 23 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | None | |||
| CHEMBL18772 | 3262 | 95 | 125I-ICYP | -2 | 23 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | None | |||
| 1588 | 2325 | 27 | 125I-CYP | -58 | 44 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 28864 | 2325 | 27 | 125I-CYP | -58 | 44 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 43 | 2325 | 27 | 125I-CYP | -58 | 44 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| CHEMBL157138 | 2325 | 27 | 125I-CYP | -58 | 44 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| DB00589 | 2325 | 27 | 125I-CYP | -58 | 44 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 132 | 1275 | 13 | 3H-GR-125743 | -6456 | 15 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| 155346 | 1275 | 13 | 3H-GR-125743 | -6456 | 15 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| CHEMBL378501 | 1275 | 13 | 3H-GR-125743 | -6456 | 15 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| 115237 | 55585 | 119 | 3H-Alniditan | -93 | 54 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | |||
| CHEMBL1621 | 55585 | 119 | 3H-Alniditan | -93 | 54 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | |||
| 5 | 139 | 72 | 125I-CYP | -13 | 54 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 125I-CYP | -13 | 54 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 125I-CYP | -13 | 54 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 125I-CYP | -13 | 54 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 145 | 140 | 49 | 3H-5HT | -8 | 30 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 1832 | 140 | 49 | 3H-5HT | -8 | 30 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL7257 | 140 | 49 | 3H-5HT | -8 | 30 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB14010 | 140 | 49 | 3H-5HT | -8 | 30 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 15897 | 2862 | 0 | 3H-GR-125743 | -95 | 36 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 203 | 2 | 1 | 1 | 2.6 | CC(Cc1cccc(c1)C(F)(F)F)N | None | |||
| 215 | 2862 | 0 | 3H-GR-125743 | -95 | 36 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 203 | 2 | 1 | 1 | 2.6 | CC(Cc1cccc(c1)C(F)(F)F)N | None | |||
| CHEMBL1979333 | 2862 | 0 | 3H-GR-125743 | -95 | 36 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 203 | 2 | 1 | 1 | 2.6 | CC(Cc1cccc(c1)C(F)(F)F)N | None | |||
| 542051 | 206100 | 6 | 3H-5HT | -2630 | 7 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 237 | 6 | 1 | 3 | 2.5 | CCCc1cc(OC)c(CC(C)N)cc1OC | None | |||
| CHEMBL8569 | 206100 | 6 | 3H-5HT | -2630 | 7 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 237 | 6 | 1 | 3 | 2.5 | CCCc1cc(OC)c(CC(C)N)cc1OC | None | |||
| 127 | 3126 | 52 | 125I-ICYP | -95 | 15 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 688095 | 3126 | 52 | 125I-ICYP | -95 | 15 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| CHEMBL117405 | 3126 | 52 | 125I-ICYP | -95 | 15 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 5 | 139 | 72 | 125I-CYP | -13 | 54 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 125I-CYP | -13 | 54 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 125I-CYP | -13 | 54 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 125I-CYP | -13 | 54 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 15897 | 2862 | 0 | 3H-GR-125743 | -95 | 36 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 203 | 2 | 1 | 1 | 2.6 | CC(Cc1cccc(c1)C(F)(F)F)N | None | |||
| 215 | 2862 | 0 | 3H-GR-125743 | -95 | 36 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 203 | 2 | 1 | 1 | 2.6 | CC(Cc1cccc(c1)C(F)(F)F)N | None | |||
| CHEMBL1979333 | 2862 | 0 | 3H-GR-125743 | -95 | 36 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 203 | 2 | 1 | 1 | 2.6 | CC(Cc1cccc(c1)C(F)(F)F)N | None | |||
| 115 | 3791 | 80 | 3H-5HT | -2 | 27 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 4296 | 3791 | 80 | 3H-5HT | -2 | 27 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| CHEMBL274866 | 3791 | 80 | 3H-5HT | -2 | 27 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 123686 | 1981 | 51 | 3H-5HT | -2630 | 9 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 354 | 9 | 4 | 5 | 1.7 | C1=CC=C(C=C1)NC(=O)NCCNCC(COC2=CC=CC=C2C#N)O | None | |||
| 12581 | 1981 | 51 | 3H-5HT | -2630 | 9 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 354 | 9 | 4 | 5 | 1.7 | C1=CC=C(C=C1)NC(=O)NCCNCC(COC2=CC=CC=C2C#N)O | None | |||
| CHEMBL11268 | 1981 | 51 | 3H-5HT | -2630 | 9 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 354 | 9 | 4 | 5 | 1.7 | C1=CC=C(C=C1)NC(=O)NCCNCC(COC2=CC=CC=C2C#N)O | None | |||
| 27402 | 205686 | 18 | 3H-5HT | -46 | 6 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 223 | 5 | 1 | 3 | 2.2 | CCc1cc(OC)c(CC(C)N)cc1OC | None | |||
| CHEMBL8224 | 205686 | 18 | 3H-5HT | -46 | 6 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 223 | 5 | 1 | 3 | 2.2 | CCc1cc(OC)c(CC(C)N)cc1OC | None | |||
| 173 | 3262 | 95 | 125I-ICYP | -2 | 23 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | None | |||
| 5011 | 3262 | 95 | 125I-ICYP | -2 | 23 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | None | |||
| CHEMBL18772 | 3262 | 95 | 125I-ICYP | -2 | 23 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | None | |||
| 134 | 2514 | 24 | 3H-5HT | -14 | 67 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1775 | 2514 | 24 | 3H-5HT | -14 | 67 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 9681 | 2514 | 24 | 3H-5HT | -14 | 67 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| CHEMBL1065 | 2514 | 24 | 3H-5HT | -14 | 67 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| DB00247 | 2514 | 24 | 3H-5HT | -14 | 67 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 2543 | 3707 | 68 | 3H-GR-125743 | -3 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | 3H-GR-125743 | -3 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | 3H-GR-125743 | -3 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | 3H-GR-125743 | -3 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | 3H-GR-125743 | -3 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 127 | 3126 | 52 | 3H-GR-125743 | -95 | 15 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 688095 | 3126 | 52 | 3H-GR-125743 | -95 | 15 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| CHEMBL117405 | 3126 | 52 | 3H-GR-125743 | -95 | 15 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 133 | 2496 | 52 | 3H-5HT | -40 | 42 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 1723 | 2496 | 52 | 3H-5HT | -40 | 42 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 28693 | 2496 | 52 | 3H-5HT | -40 | 42 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| CHEMBL19215 | 2496 | 52 | 3H-5HT | -40 | 42 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| DB13520 | 2496 | 52 | 3H-5HT | -40 | 42 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 135398737 | 958 | 93 | 3H-5HT | -691 | 89 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 38 | 958 | 93 | 3H-5HT | -691 | 89 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 722 | 958 | 93 | 3H-5HT | -691 | 89 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| CHEMBL42 | 958 | 93 | 3H-5HT | -691 | 89 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| DB00363 | 958 | 93 | 3H-5HT | -691 | 89 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| None | 215944 | 0 | 3H-5HT | -229 | 7 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 455 | 6 | 5 | 5 | 1.6 | CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C.C(=CC(=O)O)C(=O)O | None | |||
| 138107169 | 215952 | 0 | 3H-5HT | -141 | 22 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O | None | |||
| 22831402 | 215952 | 0 | 3H-5HT | -141 | 22 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O | None | |||
| 7153 | 98020 | 77 | UNDEFINED | -10 | 34 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | |||
| CHEMBL272942 | 98020 | 77 | UNDEFINED | -10 | 34 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | |||
| 1524 | 2181 | 96 | 3H-GR-125743 | -2511 | 52 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 197 | 2181 | 96 | 3H-GR-125743 | -2511 | 52 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 3822 | 2181 | 96 | 3H-GR-125743 | -2511 | 52 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 88 | 2181 | 96 | 3H-GR-125743 | -2511 | 52 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| CHEMBL51 | 2181 | 96 | 3H-GR-125743 | -2511 | 52 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| DB12465 | 2181 | 96 | 3H-GR-125743 | -2511 | 52 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 7153 | 98020 | 77 | 125I-ICYP | -10 | 34 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | |||
| CHEMBL272942 | 98020 | 77 | 125I-ICYP | -10 | 34 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | |||
| 1220 | 187 | 55 | 3H-5HT | -208 | 44 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 31 | 187 | 55 | 3H-5HT | -208 | 44 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 7 | 187 | 55 | 3H-5HT | -208 | 44 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| CHEMBL56 | 187 | 55 | 3H-5HT | -208 | 44 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 2601 | 3780 | 33 | 3H-GR-125743 | -87 | 21 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 443951 | 3780 | 33 | 3H-GR-125743 | -87 | 21 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 56 | 3780 | 33 | 3H-GR-125743 | -87 | 21 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| CHEMBL73151 | 3780 | 33 | 3H-GR-125743 | -87 | 21 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| DB13399 | 3780 | 33 | 3H-GR-125743 | -87 | 21 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 1220 | 187 | 55 | 3H-5HT | -208 | 44 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 31 | 187 | 55 | 3H-5HT | -208 | 44 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 7 | 187 | 55 | 3H-5HT | -208 | 44 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| CHEMBL56 | 187 | 55 | 3H-5HT | -208 | 44 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 115 | 3791 | 80 | 125I-ICYP | 1 | 27 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 4296 | 3791 | 80 | 125I-ICYP | 1 | 27 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| CHEMBL274866 | 3791 | 80 | 125I-ICYP | 1 | 27 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 102 | 4127 | 48 | 3H-5HT | -64 | 49 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 3659 | 4127 | 48 | 3H-5HT | -64 | 49 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 8969 | 4127 | 48 | 3H-5HT | -64 | 49 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| CHEMBL15245 | 4127 | 48 | 3H-5HT | -64 | 49 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| DB01392 | 4127 | 48 | 3H-5HT | -64 | 49 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 173 | 3262 | 95 | 3H-5HT | -2 | 23 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | None | |||
| 5011 | 3262 | 95 | 3H-5HT | -2 | 23 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | None | |||
| CHEMBL18772 | 3262 | 95 | 3H-5HT | -2 | 23 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | None | |||
| 7153 | 98020 | 77 | 125I-CYP | -10 | 34 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | |||
| CHEMBL272942 | 98020 | 77 | 125I-CYP | -10 | 34 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | |||
| 5074 | 3332 | 80 | 3H-GR-125743 | -478 | 30 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | None | |||
| 97 | 3332 | 80 | 3H-GR-125743 | -478 | 30 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | None | |||
| CHEMBL267777 | 3332 | 80 | 3H-GR-125743 | -478 | 30 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | None | |||
| DB12693 | 3332 | 80 | 3H-GR-125743 | -478 | 30 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | None | |||
| 2303 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 4946 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 564 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 63 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 91536 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| CHEMBL27 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| CHEMBL452861 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| DB00571 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 115 | 3791 | 80 | 3H-5HT | 1 | 27 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 4296 | 3791 | 80 | 3H-5HT | 1 | 27 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| CHEMBL274866 | 3791 | 80 | 3H-5HT | 1 | 27 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 115 | 3791 | 80 | 3H-5HT | -2 | 27 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 4296 | 3791 | 80 | 3H-5HT | -2 | 27 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| CHEMBL274866 | 3791 | 80 | 3H-5HT | -2 | 27 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 1353 | 1911 | 93 | 3H-Alniditan | -66 | 83 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 3559 | 1911 | 93 | 3H-Alniditan | -66 | 83 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 86 | 1911 | 93 | 3H-Alniditan | -66 | 83 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| CHEMBL54 | 1911 | 93 | 3H-Alniditan | -66 | 83 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| DB00502 | 1911 | 93 | 3H-Alniditan | -66 | 83 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 2389 | 3331 | 118 | 3H-5HT | -6456 | 67 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 5073 | 3331 | 118 | 3H-5HT | -6456 | 67 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 96 | 3331 | 118 | 3H-5HT | -6456 | 67 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| CHEMBL85 | 3331 | 118 | 3H-5HT | -6456 | 67 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| DB00734 | 3331 | 118 | 3H-5HT | -6456 | 67 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 1342 | 35 | 49 | 125I-CYP | -50 | 19 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| 3 | 35 | 49 | 125I-CYP | -50 | 19 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| CHEMBL277120 | 35 | 49 | 125I-CYP | -50 | 19 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| 165193 | 215945 | 0 | 3H-GR-125743 | -11748 | 30 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 62882 | 215945 | 0 | 3H-GR-125743 | -11748 | 30 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 66366 | 215945 | 0 | 3H-GR-125743 | -11748 | 30 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 2543 | 3707 | 68 | 3H-GR-125743 | -3 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | 3H-GR-125743 | -3 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | 3H-GR-125743 | -3 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | 3H-GR-125743 | -3 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | 3H-GR-125743 | -3 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 115 | 3791 | 80 | 3H-5HT | -2 | 27 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 4296 | 3791 | 80 | 3H-5HT | -2 | 27 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| CHEMBL274866 | 3791 | 80 | 3H-5HT | -2 | 27 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 133 | 2496 | 52 | 3H-GR-125743 | -52 | 42 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 1723 | 2496 | 52 | 3H-GR-125743 | -52 | 42 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 28693 | 2496 | 52 | 3H-GR-125743 | -52 | 42 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| CHEMBL19215 | 2496 | 52 | 3H-GR-125743 | -52 | 42 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| DB13520 | 2496 | 52 | 3H-GR-125743 | -52 | 42 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 135 | 2532 | 43 | 125I-ICYP | -851 | 58 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 1796 | 2532 | 43 | 125I-ICYP | -851 | 58 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 4184 | 2532 | 43 | 125I-ICYP | -851 | 58 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| CHEMBL6437 | 2532 | 43 | 125I-ICYP | -851 | 58 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| DB06148 | 2532 | 43 | 125I-ICYP | -851 | 58 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 2105 | 3054 | 37 | 3H-GR-125743 | -436 | 33 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
| 47811 | 3054 | 37 | 3H-GR-125743 | -436 | 33 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
| 48 | 3054 | 37 | 3H-GR-125743 | -436 | 33 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
| CHEMBL531 | 3054 | 37 | 3H-GR-125743 | -436 | 33 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
| DB01186 | 3054 | 37 | 3H-GR-125743 | -436 | 33 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
| 4452 | 2762 | 19 | 3H-5CT | -95499 | 19 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 387 | 6 | 2 | 4 | 3.8 | COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl | None | |||
| 983 | 2762 | 19 | 3H-5CT | -95499 | 19 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 387 | 6 | 2 | 4 | 3.8 | COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl | None | |||
| CHEMBL20734 | 2762 | 19 | 3H-5CT | -95499 | 19 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 387 | 6 | 2 | 4 | 3.8 | COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl | None | |||
| 1220 | 187 | 55 | 3H-5HT | -208 | 44 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 31 | 187 | 55 | 3H-5HT | -208 | 44 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 7 | 187 | 55 | 3H-5HT | -208 | 44 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| CHEMBL56 | 187 | 55 | 3H-5HT | -208 | 44 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 1353 | 1911 | 93 | 3H-Alniditan | -66 | 83 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 3559 | 1911 | 93 | 3H-Alniditan | -66 | 83 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 86 | 1911 | 93 | 3H-Alniditan | -66 | 83 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| CHEMBL54 | 1911 | 93 | 3H-Alniditan | -66 | 83 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| DB00502 | 1911 | 93 | 3H-Alniditan | -66 | 83 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 135398745 | 2914 | 112 | 3H-5HT | -162 | 65 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| 47 | 2914 | 112 | 3H-5HT | -162 | 65 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| CHEMBL715 | 2914 | 112 | 3H-5HT | -162 | 65 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| DB00334 | 2914 | 112 | 3H-5HT | -162 | 65 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| 3337 | 206367 | 27 | 3H-GR-125743 | -74 | 40 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
| 65801 | 206367 | 27 | 3H-GR-125743 | -74 | 40 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
| 66264 | 206367 | 27 | 3H-GR-125743 | -74 | 40 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
| 91452 | 206367 | 27 | 3H-GR-125743 | -74 | 40 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
| CHEMBL87493 | 206367 | 27 | 3H-GR-125743 | -74 | 40 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
| 60820 | 4308 | 14 | UNDEFINED | -144543 | 13 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 421 | 6 | 0 | 4 | 4.4 | CC(C)Oc1ccccc1N1CCN(Cc2cccc(C(=O)N3CCCCC3)c2)CC1 | None | |||
| CHEMBL10085 | 4308 | 14 | UNDEFINED | -144543 | 13 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 421 | 6 | 0 | 4 | 4.4 | CC(C)Oc1ccccc1N1CCN(Cc2cccc(C(=O)N3CCCCC3)c2)CC1 | None | |||
| 5074 | 3332 | 80 | 3H-GR-125743 | -478 | 30 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | None | |||
| 97 | 3332 | 80 | 3H-GR-125743 | -478 | 30 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | None | |||
| CHEMBL267777 | 3332 | 80 | 3H-GR-125743 | -478 | 30 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | None | |||
| DB12693 | 3332 | 80 | 3H-GR-125743 | -478 | 30 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | None | |||
| 4209 | 3163 | 75 | 125I-ICYP | -9549 | 33 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | None | |||
| 4893 | 3163 | 75 | 125I-ICYP | -9549 | 33 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | None | |||
| 503 | 3163 | 75 | 125I-ICYP | -9549 | 33 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | None | |||
| 5385 | 3163 | 75 | 125I-ICYP | -9549 | 33 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | None | |||
| CHEMBL2 | 3163 | 75 | 125I-ICYP | -9549 | 33 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | None | |||
| DB00457 | 3163 | 75 | 125I-ICYP | -9549 | 33 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | None | |||
| 6437377 | 215954 | 0 | 125I-CYP | -2398 | 5 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 500 | 6 | 3 | 7 | 3.2 | CC(C)N1C=C2CC3C(CC(CN3C)C(=O)OC(C)C(C)O)C4=C2C1=CC=C4.C(=CC(=O)O)C(=O)O | None | |||
| 25058166 | 215960 | 0 | 3H-GR-125743 | -1479 | 27 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 267 | 0 | 2 | 3 | 2.9 | CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O | None | |||
| 6852389 | 215960 | 0 | 3H-GR-125743 | -1479 | 27 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 267 | 0 | 2 | 3 | 2.9 | CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O | None | |||
| 5 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 4106 | 2502 | 22 | 3H-5HT | -11 | 34 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 5358812 | 2502 | 22 | 3H-5HT | -11 | 34 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 89 | 2502 | 22 | 3H-5HT | -11 | 34 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| CHEMBL93240 | 2502 | 22 | 3H-5HT | -11 | 34 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 107780 | 1844 | 54 | 3H-5HT | -4 | 17 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 14 | 1844 | 54 | 3H-5HT | -4 | 17 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| CHEMBL15928 | 1844 | 54 | 3H-5HT | -4 | 17 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 115 | 3791 | 80 | 3H-5HT | 1 | 27 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 4296 | 3791 | 80 | 3H-5HT | 1 | 27 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| CHEMBL274866 | 3791 | 80 | 3H-5HT | 1 | 27 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 115 | 3791 | 80 | 3H-5HT | 1 | 27 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 4296 | 3791 | 80 | 3H-5HT | 1 | 27 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| CHEMBL274866 | 3791 | 80 | 3H-5HT | 1 | 27 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 1809 | 134 | 32 | 3H-5HT | -32 | 36 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-5HT | -32 | 36 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-5HT | -32 | 36 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 2543 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 134 | 2514 | 24 | 3H-5HT | -14 | 67 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1775 | 2514 | 24 | 3H-5HT | -14 | 67 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 9681 | 2514 | 24 | 3H-5HT | -14 | 67 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| CHEMBL1065 | 2514 | 24 | 3H-5HT | -14 | 67 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| DB00247 | 2514 | 24 | 3H-5HT | -14 | 67 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 130 | 3500 | 47 | 3H-GR-125743 | 1 | 13 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 3378093 | 3500 | 47 | 3H-GR-125743 | 1 | 13 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| CHEMBL281350 | 3500 | 47 | 3H-GR-125743 | 1 | 13 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| None | 215938 | 0 | 3H-5HT | -18 | 21 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 583 | 4 | 3 | 6 | 2.1 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C | None | |||
| None | 215946 | 0 | 125I-CYP | 2 | 24 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 346 | 5 | 4 | 4 | 2.5 | COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O | None | |||
| None | 215946 | 0 | 3H-5HT | 2 | 24 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 346 | 5 | 4 | 4 | 2.5 | COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O | None | |||
| 5 | 139 | 72 | 3H-5HT | -11 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-5HT | -11 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-5HT | -11 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-5HT | -11 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 1621 | 2429 | 17 | 3H-GR-125743 | -97 | 45 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 17 | 2429 | 17 | 3H-GR-125743 | -97 | 45 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 5761 | 2429 | 17 | 3H-GR-125743 | -97 | 45 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| CHEMBL263881 | 2429 | 17 | 3H-GR-125743 | -97 | 45 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| DB04829 | 2429 | 17 | 3H-GR-125743 | -97 | 45 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 46780481 | 107531 | 20 | 3H-Alniditan | -32 | 53 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| 9903970 | 107531 | 20 | 3H-Alniditan | -32 | 53 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| CHEMBL3187365 | 107531 | 20 | 3H-Alniditan | -32 | 53 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| CHEMBL3544974 | 107531 | 20 | 3H-Alniditan | -32 | 53 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| None | 215946 | 0 | 125I-CYP | 2 | 24 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 346 | 5 | 4 | 4 | 2.5 | COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O | None | |||
| 6971132 | 216009 | 0 | 3H-5-CT | 1 | 14 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 268 | 1 | 2 | 2 | 2.1 | CN1CC(C=C2C1CC3=CNC4=CC=CC2=C34)C(=O)O | None | |||
| 5 | 139 | 72 | 3H-5HT | -11 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-5HT | -11 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-5HT | -11 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-5HT | -11 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 130 | 3500 | 47 | 3H-GR-125743 | -8 | 13 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 3378093 | 3500 | 47 | 3H-GR-125743 | -8 | 13 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| CHEMBL281350 | 3500 | 47 | 3H-GR-125743 | -8 | 13 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 107 | 141 | 121 | 3H-5HT | -30 | 30 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1833 | 141 | 121 | 3H-5HT | -30 | 30 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| CHEMBL8165 | 141 | 121 | 3H-5HT | -30 | 30 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 165193 | 215945 | 0 | 3H-5HT | -154 | 30 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 62882 | 215945 | 0 | 3H-5HT | -154 | 30 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 66366 | 215945 | 0 | 3H-5HT | -154 | 30 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 152662 | 215957 | 0 | 125I-CYP | 109 | 7 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 276 | 5 | 3 | 3 | 2.6 | CC1=CC2=C(N1)C=CC=C2OCC(CNC(C)(C)C)O | None | |||
| 173 | 3262 | 95 | 3H-5HT | -2 | 23 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | None | |||
| 5011 | 3262 | 95 | 3H-5HT | -2 | 23 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | None | |||
| CHEMBL18772 | 3262 | 95 | 3H-5HT | -2 | 23 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | None | |||
| 173 | 3262 | 95 | 125I-CYP | -2 | 23 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | None | |||
| 173 | 3262 | 95 | 3H-5HT | -2 | 23 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | None | |||
| 5011 | 3262 | 95 | 125I-CYP | -2 | 23 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | None | |||
| 5011 | 3262 | 95 | 3H-5HT | -2 | 23 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | None | |||
| CHEMBL18772 | 3262 | 95 | 125I-CYP | -2 | 23 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | None | |||
| CHEMBL18772 | 3262 | 95 | 3H-5HT | -2 | 23 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 213 | 1 | 1 | 3 | 1.6 | N1CCN(CC1)c1ccc2c(n1)cccc2 | None | |||
| 134 | 2514 | 24 | 3H-GR-125743 | -251 | 67 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1775 | 2514 | 24 | 3H-GR-125743 | -251 | 67 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 9681 | 2514 | 24 | 3H-GR-125743 | -251 | 67 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| CHEMBL1065 | 2514 | 24 | 3H-GR-125743 | -251 | 67 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| DB00247 | 2514 | 24 | 3H-GR-125743 | -251 | 67 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 2220 | 3134 | 82 | 125I-CYP | -1023 | 14 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 295 | 0 | 0 | 2 | 4.4 | CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 | None | |||
| 27400 | 3134 | 82 | 125I-CYP | -1023 | 14 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 295 | 0 | 0 | 2 | 4.4 | CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 | None | |||
| 93 | 3134 | 82 | 125I-CYP | -1023 | 14 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 295 | 0 | 0 | 2 | 4.4 | CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 | None | |||
| CHEMBL294951 | 3134 | 82 | 125I-CYP | -1023 | 14 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 295 | 0 | 0 | 2 | 4.4 | CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 | None | |||
| DB06153 | 3134 | 82 | 125I-CYP | -1023 | 14 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 295 | 0 | 0 | 2 | 4.4 | CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 | None | |||
| 4106 | 2502 | 22 | 3H-GR-125743 | -11 | 34 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 5358812 | 2502 | 22 | 3H-GR-125743 | -11 | 34 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 89 | 2502 | 22 | 3H-GR-125743 | -11 | 34 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| CHEMBL93240 | 2502 | 22 | 3H-GR-125743 | -11 | 34 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 135398745 | 2914 | 112 | 3H-5CT | -199 | 65 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| 47 | 2914 | 112 | 3H-5CT | -199 | 65 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| CHEMBL715 | 2914 | 112 | 3H-5CT | -199 | 65 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| DB00334 | 2914 | 112 | 3H-5CT | -199 | 65 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| 5311189 | 204841 | 11 | 3H-GR-125743 | -61 | 27 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 219 | 3 | 1 | 2 | 3.0 | CCCN1CCC[C@@H](c2cccc(O)c2)C1 | None | |||
| CHEMBL7549 | 204841 | 11 | 3H-GR-125743 | -61 | 27 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 219 | 3 | 1 | 2 | 3.0 | CCCN1CCC[C@@H](c2cccc(O)c2)C1 | None | |||
| 24881686 | 188389 | 0 | UNDEFINED | -8 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 832 | 18 | 4 | 7 | 8.5 | O=C(Nc1ccc2[nH]cc(C3CCN(CCOCCOCCOCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | None | |||
| CHEMBL501645 | 188389 | 0 | UNDEFINED | -8 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 832 | 18 | 4 | 7 | 8.5 | O=C(Nc1ccc2[nH]cc(C3CCN(CCOCCOCCOCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | None | |||
| 71299720 | 215951 | 0 | 125I-ICYP | -44 | 17 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 450 | 3 | 2 | 6 | 3.0 | CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4.C(=CC(=O)O)C(=O)O | None | |||
| None | 215946 | 0 | 3H-GR-125743 | -22 | 24 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 346 | 5 | 4 | 4 | 2.5 | COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O | None | |||
| 5 | 139 | 72 | 125I-ICYP | -13 | 54 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 125I-ICYP | -13 | 54 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 125I-ICYP | -13 | 54 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 125I-ICYP | -13 | 54 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 145 | 140 | 49 | 3H-5HT | -47 | 30 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 1832 | 140 | 49 | 3H-5HT | -47 | 30 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL7257 | 140 | 49 | 3H-5HT | -47 | 30 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB14010 | 140 | 49 | 3H-5HT | -47 | 30 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| None | 216239 | 0 | 3H-GR-125743 | -4677 | 30 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 316 | 7 | 3 | 3 | 3.0 | CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O | None | |||
| 115237 | 55585 | 119 | 3H-5HT | -14454 | 54 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | |||
| CHEMBL1621 | 55585 | 119 | 3H-5HT | -14454 | 54 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | |||
| 135398737 | 958 | 93 | 3H-5HT | -691 | 89 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 38 | 958 | 93 | 3H-5HT | -691 | 89 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 722 | 958 | 93 | 3H-5HT | -691 | 89 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| CHEMBL42 | 958 | 93 | 3H-5HT | -691 | 89 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| DB00363 | 958 | 93 | 3H-5HT | -691 | 89 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 107 | 141 | 121 | 3H-5HT | -16 | 30 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1833 | 141 | 121 | 3H-5HT | -16 | 30 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| CHEMBL8165 | 141 | 121 | 3H-5HT | -16 | 30 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1212 | 1662 | 50 | 3H-GR-125743 | -93 | 65 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
| 204 | 1662 | 50 | 3H-GR-125743 | -93 | 65 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
| 3372 | 1662 | 50 | 3H-GR-125743 | -93 | 65 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
| CHEMBL726 | 1662 | 50 | 3H-GR-125743 | -93 | 65 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
| DB00623 | 1662 | 50 | 3H-GR-125743 | -93 | 65 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
| 7153 | 98020 | 77 | 125I-CYP | -10 | 34 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | |||
| 7153 | 98020 | 77 | 3H-5HT | -10 | 34 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | |||
| CHEMBL272942 | 98020 | 77 | 125I-CYP | -10 | 34 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | |||
| CHEMBL272942 | 98020 | 77 | 3H-5HT | -10 | 34 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | |||
| 446220 | 133521 | 14 | 3H-GR-125743 | -23 | 45 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 303 | 3 | 0 | 5 | 1.9 | COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C | None | |||
| CHEMBL370805 | 133521 | 14 | 3H-GR-125743 | -23 | 45 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 303 | 3 | 0 | 5 | 1.9 | COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C | None | |||
| 2176 | 3127 | 68 | 3H-5HT | -741 | 27 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 4828 | 3127 | 68 | 3H-5HT | -741 | 27 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 91 | 3127 | 68 | 3H-5HT | -741 | 27 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| CHEMBL500 | 3127 | 68 | 3H-5HT | -741 | 27 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| DB00960 | 3127 | 68 | 3H-5HT | -741 | 27 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 15897 | 2862 | 0 | 3H-GR-125743 | -95 | 36 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 203 | 2 | 1 | 1 | 2.6 | CC(Cc1cccc(c1)C(F)(F)F)N | None | |||
| 215 | 2862 | 0 | 3H-GR-125743 | -95 | 36 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 203 | 2 | 1 | 1 | 2.6 | CC(Cc1cccc(c1)C(F)(F)F)N | None | |||
| CHEMBL1979333 | 2862 | 0 | 3H-GR-125743 | -95 | 36 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 203 | 2 | 1 | 1 | 2.6 | CC(Cc1cccc(c1)C(F)(F)F)N | None | |||
| 107 | 141 | 121 | 3H-GR-125743 | -16 | 30 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1833 | 141 | 121 | 3H-GR-125743 | -16 | 30 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| CHEMBL8165 | 141 | 121 | 3H-GR-125743 | -16 | 30 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| None | 215950 | 0 | 125I-ICYP | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 310 | 7 | 2 | 4 | 2.6 | CC(C)NCC(COC1=CC=CC=C1N2C=CC=C2)O.Cl | None | |||
| 115237 | 55585 | 119 | 3H-5HT | -14454 | 54 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | |||
| CHEMBL1621 | 55585 | 119 | 3H-5HT | -14454 | 54 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | |||
| 119570 | 3159 | 96 | 3H-GR-125743 | -660 | 40 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | |||
| 2233 | 3159 | 96 | 3H-GR-125743 | -660 | 40 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | |||
| 953 | 3159 | 96 | 3H-GR-125743 | -660 | 40 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | |||
| CHEMBL301265 | 3159 | 96 | 3H-GR-125743 | -660 | 40 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | |||
| DB00413 | 3159 | 96 | 3H-GR-125743 | -660 | 40 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | |||
| 145 | 140 | 49 | 125I-ICYP | -47 | 30 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 1832 | 140 | 49 | 125I-ICYP | -47 | 30 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL7257 | 140 | 49 | 125I-ICYP | -47 | 30 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB14010 | 140 | 49 | 125I-ICYP | -47 | 30 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 11831220 | 192558 | 8 | UNDEFINED | -8 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 229 | 1 | 2 | 2 | 2.6 | CN1CCC(c2c[nH]c3ccc(N)cc23)CC1 | None | |||
| CHEMBL521235 | 192558 | 8 | UNDEFINED | -8 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 229 | 1 | 2 | 2 | 2.6 | CN1CCC(c2c[nH]c3ccc(N)cc23)CC1 | None | |||
| 31101 | 729 | 40 | 3H-GR-125743 | -128 | 36 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
| 35 | 729 | 40 | 3H-GR-125743 | -128 | 36 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
| 403 | 729 | 40 | 3H-GR-125743 | -128 | 36 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
| CHEMBL493 | 729 | 40 | 3H-GR-125743 | -128 | 36 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
| DB01200 | 729 | 40 | 3H-GR-125743 | -128 | 36 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
| 133 | 2496 | 52 | 3H-5HT | -23 | 42 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 1723 | 2496 | 52 | 3H-5HT | -23 | 42 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 28693 | 2496 | 52 | 3H-5HT | -23 | 42 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| CHEMBL19215 | 2496 | 52 | 3H-5HT | -23 | 42 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| DB13520 | 2496 | 52 | 3H-5HT | -23 | 42 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 165193 | 215945 | 0 | 3H-GR-125743 | -154 | 30 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 62882 | 215945 | 0 | 3H-GR-125743 | -154 | 30 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 66366 | 215945 | 0 | 3H-GR-125743 | -154 | 30 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 7153 | 98020 | 77 | 3H-5HT | -11 | 34 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | |||
| CHEMBL272942 | 98020 | 77 | 3H-5HT | -11 | 34 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | |||
| 2181 | 3128 | 46 | 3H-5HT | -3090 | 35 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| 4830 | 3128 | 46 | 3H-5HT | -3090 | 35 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| 92 | 3128 | 46 | 3H-5HT | -3090 | 35 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| CHEMBL440294 | 3128 | 46 | 3H-5HT | -3090 | 35 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| DB09286 | 3128 | 46 | 3H-5HT | -3090 | 35 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| 4595 | 176715 | 106 | 3H-Serotonin | -7 | 15 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 293 | 2 | 0 | 4 | 3.1 | Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O | None | |||
| CHEMBL46 | 176715 | 106 | 3H-Serotonin | -7 | 15 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 293 | 2 | 0 | 4 | 3.1 | Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O | None | |||
| 5074 | 3332 | 80 | 3H-GR-125743 | -645 | 30 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | None | |||
| 97 | 3332 | 80 | 3H-GR-125743 | -645 | 30 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | None | |||
| CHEMBL267777 | 3332 | 80 | 3H-GR-125743 | -645 | 30 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | None | |||
| DB12693 | 3332 | 80 | 3H-GR-125743 | -645 | 30 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | None | |||
| 5 | 139 | 72 | 3H-GR-125743 | -11 | 54 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-GR-125743 | -11 | 54 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-GR-125743 | -11 | 54 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-GR-125743 | -11 | 54 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 107 | 141 | 121 | 3H-GR-125743 | -16 | 30 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1833 | 141 | 121 | 3H-GR-125743 | -16 | 30 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| CHEMBL8165 | 141 | 121 | 3H-GR-125743 | -16 | 30 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1220 | 187 | 55 | 3H-5HT | -208 | 44 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 31 | 187 | 55 | 3H-5HT | -208 | 44 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 7 | 187 | 55 | 3H-5HT | -208 | 44 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| CHEMBL56 | 187 | 55 | 3H-5HT | -208 | 44 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 24882266 | 188287 | 0 | UNDEFINED | -2 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 812 | 17 | 4 | 4 | 11.6 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | None | |||
| CHEMBL500230 | 188287 | 0 | UNDEFINED | -2 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 812 | 17 | 4 | 4 | 11.6 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | None | |||
| 1220 | 187 | 55 | 3H-5HT | -208 | 44 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 31 | 187 | 55 | 3H-5HT | -208 | 44 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 7 | 187 | 55 | 3H-5HT | -208 | 44 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| CHEMBL56 | 187 | 55 | 3H-5HT | -208 | 44 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 134 | 2514 | 24 | 125I-ICYP | -251 | 67 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1775 | 2514 | 24 | 125I-ICYP | -251 | 67 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 9681 | 2514 | 24 | 125I-ICYP | -251 | 67 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| CHEMBL1065 | 2514 | 24 | 125I-ICYP | -251 | 67 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| DB00247 | 2514 | 24 | 125I-ICYP | -251 | 67 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1613 | 2348 | 53 | 3H-GR-125743 | -13 | 44 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
| 205 | 2348 | 53 | 3H-GR-125743 | -13 | 44 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
| 3964 | 2348 | 53 | 3H-GR-125743 | -13 | 44 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
| CHEMBL831 | 2348 | 53 | 3H-GR-125743 | -13 | 44 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
| DB00408 | 2348 | 53 | 3H-GR-125743 | -13 | 44 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
| 3682 | 189437 | 12 | 125I-ICYP | -7585 | 8 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 277 | 6 | 2 | 3 | 2.6 | Cc1ccc(OCC(O)C(C)NC(C)C)c2c1CCC2 | None | |||
| CHEMBL1256784 | 189437 | 12 | 125I-ICYP | -7585 | 8 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 277 | 6 | 2 | 3 | 2.6 | Cc1ccc(OCC(O)C(C)NC(C)C)c2c1CCC2 | None | |||
| CHEMBL513389 | 189437 | 12 | 125I-ICYP | -7585 | 8 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 277 | 6 | 2 | 3 | 2.6 | Cc1ccc(OCC(O)C(C)NC(C)C)c2c1CCC2 | None | |||
| 1621 | 2429 | 17 | 125I-ICYP | -97 | 45 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 17 | 2429 | 17 | 125I-ICYP | -97 | 45 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 5761 | 2429 | 17 | 125I-ICYP | -97 | 45 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| CHEMBL263881 | 2429 | 17 | 125I-ICYP | -97 | 45 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| DB04829 | 2429 | 17 | 125I-ICYP | -97 | 45 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 165193 | 215945 | 0 | 125I-ICYP | -154 | 30 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 62882 | 215945 | 0 | 125I-ICYP | -154 | 30 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 66366 | 215945 | 0 | 125I-ICYP | -154 | 30 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 1342 | 35 | 49 | 125I-ICYP | -50 | 19 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| 3 | 35 | 49 | 125I-ICYP | -50 | 19 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| CHEMBL277120 | 35 | 49 | 125I-ICYP | -50 | 19 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| 5 | 139 | 72 | 3H-5HT | -41 | 54 | Mouse | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-5HT | -41 | 54 | Mouse | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-5HT | -41 | 54 | Mouse | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-5HT | -41 | 54 | Mouse | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 4106 | 2502 | 22 | 3H-5HT | -11 | 34 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 5358812 | 2502 | 22 | 3H-5HT | -11 | 34 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 89 | 2502 | 22 | 3H-5HT | -11 | 34 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| CHEMBL93240 | 2502 | 22 | 3H-5HT | -11 | 34 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 2543 | 3707 | 68 | 3H-GR-125743 | -17 | 32 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | 3H-GR-125743 | -17 | 32 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | 3H-GR-125743 | -17 | 32 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | 3H-GR-125743 | -17 | 32 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | 3H-GR-125743 | -17 | 32 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 138107169 | 215952 | 0 | 3H-5HT | -141 | 22 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O | None | |||
| 22831402 | 215952 | 0 | 3H-5HT | -141 | 22 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O | None | |||
| 135398737 | 958 | 93 | 3H-Alniditan | -151 | 89 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 38 | 958 | 93 | 3H-Alniditan | -151 | 89 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 722 | 958 | 93 | 3H-Alniditan | -151 | 89 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| CHEMBL42 | 958 | 93 | 3H-Alniditan | -151 | 89 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| DB00363 | 958 | 93 | 3H-Alniditan | -151 | 89 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 202 | 1508 | 77 | 3H-5HT | -1 | 30 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| 60835 | 1508 | 77 | 3H-5HT | -1 | 30 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| 972 | 1508 | 77 | 3H-5HT | -1 | 30 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| CHEMBL1175 | 1508 | 77 | 3H-5HT | -1 | 30 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| DB00476 | 1508 | 77 | 3H-5HT | -1 | 30 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| 107 | 141 | 121 | 125I-CYP | -30 | 30 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 107 | 141 | 121 | 3H-5HT | -30 | 30 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1833 | 141 | 121 | 125I-CYP | -30 | 30 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1833 | 141 | 121 | 3H-5HT | -30 | 30 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| CHEMBL8165 | 141 | 121 | 125I-CYP | -30 | 30 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| CHEMBL8165 | 141 | 121 | 3H-5HT | -30 | 30 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 135398737 | 958 | 93 | 3H-GR-125743 | -151 | 89 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 38 | 958 | 93 | 3H-GR-125743 | -151 | 89 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 722 | 958 | 93 | 3H-GR-125743 | -151 | 89 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| CHEMBL42 | 958 | 93 | 3H-GR-125743 | -151 | 89 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| DB00363 | 958 | 93 | 3H-GR-125743 | -151 | 89 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 1809 | 134 | 32 | 125I-ICYP | -32 | 36 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 125I-ICYP | -32 | 36 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 125I-ICYP | -32 | 36 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 107 | 141 | 121 | 125I-ICYP | -30 | 30 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1833 | 141 | 121 | 125I-ICYP | -30 | 30 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| CHEMBL8165 | 141 | 121 | 125I-ICYP | -30 | 30 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 2865 | 4143 | 73 | 3H-GR-125743 | -12 | 53 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| 59 | 4143 | 73 | 3H-GR-125743 | -12 | 53 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| 60854 | 4143 | 73 | 3H-GR-125743 | -12 | 53 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| CHEMBL708 | 4143 | 73 | 3H-GR-125743 | -12 | 53 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| DB00246 | 4143 | 73 | 3H-GR-125743 | -12 | 53 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| None | 215946 | 0 | 125I-ICYP | 2 | 24 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 346 | 5 | 4 | 4 | 2.5 | COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O | None | |||
| 1809 | 134 | 32 | 3H-5HT | -15 | 36 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-5HT | -15 | 36 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-5HT | -15 | 36 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 5 | 139 | 72 | 35S-GTPGammaS | -11 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 35S-GTPGammaS | -11 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 35S-GTPGammaS | -11 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 35S-GTPGammaS | -11 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| None | 215938 | 0 | 125I-ICYP | -18 | 21 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 583 | 4 | 3 | 6 | 2.1 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C | None | |||
| None | 216344 | 0 | 3H-GR-125743 | 26 | 2 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 338 | 6 | 3 | 5 | 1.7 | C1CNC(=NC1)NCCCNCC2CCC3=CC=CC=C3O2.Cl | None | |||
| 5 | 139 | 72 | 3H-5HT | -11 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-5HT | -11 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-5HT | -11 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-5HT | -11 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 107780 | 1844 | 54 | 3H-GR-125743 | -4 | 17 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 14 | 1844 | 54 | 3H-GR-125743 | -4 | 17 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| CHEMBL15928 | 1844 | 54 | 3H-GR-125743 | -4 | 17 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 107780 | 1844 | 54 | 3H-GR-125743 | 1 | 17 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 14 | 1844 | 54 | 3H-GR-125743 | 1 | 17 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| CHEMBL15928 | 1844 | 54 | 3H-GR-125743 | 1 | 17 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 441383 | 20333 | 57 | None | -19 | 16 | Rat | 8.4 | pKi | = | 8.4 | Binding | Drug Central | 531 | 8 | 0 | 8 | 4.5 | CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | None | |||
| CHEMBL1306 | 20333 | 57 | None | -19 | 16 | Rat | 8.4 | pKi | = | 8.4 | Binding | Drug Central | 531 | 8 | 0 | 8 | 4.5 | CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | None | |||
| 176 | 398 | 66 | None | -10 | 31 | Rat | 8.4 | pKi | = | 8.4 | Binding | Drug Central | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | None | |||
| 2157 | 398 | 66 | None | -10 | 31 | Rat | 8.4 | pKi | = | 8.4 | Binding | Drug Central | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | None | |||
| 2566 | 398 | 66 | None | -10 | 31 | Rat | 8.4 | pKi | = | 8.4 | Binding | Drug Central | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | None | |||
| CHEMBL633 | 398 | 66 | None | -10 | 31 | Rat | 8.4 | pKi | = | 8.4 | Binding | Drug Central | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | None | |||
| DB01118 | 398 | 66 | None | -10 | 31 | Rat | 8.4 | pKi | = | 8.4 | Binding | Drug Central | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | None | |||
| 11954224 | 215953 | 0 | 3H-GR-125743 | -32 | 58 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
| 31703 | 194717 | 63 | None | -1 | 2 | Rat | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | None | |||
| CHEMBL359744 | 194717 | 63 | None | -1 | 2 | Rat | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | None | |||
| CHEMBL53463 | 194717 | 63 | None | -1 | 2 | Rat | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | None | |||
| 107 | 141 | 121 | 3H-5HT | -16 | 30 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1833 | 141 | 121 | 3H-5HT | -16 | 30 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| CHEMBL8165 | 141 | 121 | 3H-5HT | -16 | 30 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 2812 | 4779 | 101 | None | -51 | 34 | Rat | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | None | |||
| CHEMBL104 | 4779 | 101 | None | -51 | 34 | Rat | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | None | |||
| None | 215946 | 0 | 125I-ICYP | 2 | 24 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 346 | 5 | 4 | 4 | 2.5 | COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O | None | |||
| 133 | 2496 | 52 | 125I-CYP | -40 | 42 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 1723 | 2496 | 52 | 125I-CYP | -40 | 42 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 28693 | 2496 | 52 | 125I-CYP | -40 | 42 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| CHEMBL19215 | 2496 | 52 | 125I-CYP | -40 | 42 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| DB13520 | 2496 | 52 | 125I-CYP | -40 | 42 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 102 | 4127 | 48 | 3H-5HT | -64 | 49 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 3659 | 4127 | 48 | 3H-5HT | -64 | 49 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 8969 | 4127 | 48 | 3H-5HT | -64 | 49 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| CHEMBL15245 | 4127 | 48 | 3H-5HT | -64 | 49 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| DB01392 | 4127 | 48 | 3H-5HT | -64 | 49 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 2389 | 3331 | 118 | 3H-5HT | -6456 | 67 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 5073 | 3331 | 118 | 3H-5HT | -6456 | 67 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 96 | 3331 | 118 | 3H-5HT | -6456 | 67 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| CHEMBL85 | 3331 | 118 | 3H-5HT | -6456 | 67 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| DB00734 | 3331 | 118 | 3H-5HT | -6456 | 67 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 135409468 | 2035 | 69 | 3H-GR-125743 | -144 | 39 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 312 | 1 | 2 | 4 | 1.7 | Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 | None | |||
| 333 | 2035 | 69 | 3H-GR-125743 | -144 | 39 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 312 | 1 | 2 | 4 | 1.7 | Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 | None | |||
| CHEMBL845 | 2035 | 69 | 3H-GR-125743 | -144 | 39 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 312 | 1 | 2 | 4 | 1.7 | Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 | None | |||
| 5281600 | 203025 | 92 | 3H-GR-125743 | -173 | 33 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 538 | 3 | 6 | 10 | 5.1 | O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12 | None | |||
| CHEMBL63354 | 203025 | 92 | 3H-GR-125743 | -173 | 33 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 538 | 3 | 6 | 10 | 5.1 | O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12 | None | |||
| 122 | 1437 | 9 | 3H-5HT | -5 | 11 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 287 | 8 | 2 | 2 | 2.9 | CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 156314 | 1437 | 9 | 3H-5HT | -5 | 11 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 287 | 8 | 2 | 2 | 2.9 | CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL1332062 | 1437 | 9 | 3H-5HT | -5 | 11 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 287 | 8 | 2 | 2 | 2.9 | CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 2176 | 3127 | 68 | 3H-5HT | -1737 | 27 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 4828 | 3127 | 68 | 3H-5HT | -1737 | 27 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 91 | 3127 | 68 | 3H-5HT | -1737 | 27 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| CHEMBL500 | 3127 | 68 | 3H-5HT | -1737 | 27 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| DB00960 | 3127 | 68 | 3H-5HT | -1737 | 27 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 182596 | 118486 | 16 | 3H-5HT | -269 | 3 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 364 | 4 | 0 | 4 | 3.7 | c1ccc2c(c1)CCC2CCN1CCN(c2cccc3c2OCCO3)CC1 | None | |||
| CHEMBL341391 | 118486 | 16 | 3H-5HT | -269 | 3 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 364 | 4 | 0 | 4 | 3.7 | c1ccc2c(c1)CCC2CCN1CCN(c2cccc3c2OCCO3)CC1 | None | |||
| 1978 | 250 | 60 | 125I-ICYP | -645 | 6 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 336 | 10 | 3 | 5 | 3.0 | CCCC(=Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O)O | None | |||
| 40 | 250 | 60 | 125I-ICYP | -645 | 6 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 336 | 10 | 3 | 5 | 3.0 | CCCC(=Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O)O | None | |||
| 7107 | 250 | 60 | 125I-ICYP | -645 | 6 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 336 | 10 | 3 | 5 | 3.0 | CCCC(=Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O)O | None | |||
| CHEMBL642 | 250 | 60 | 125I-ICYP | -645 | 6 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 336 | 10 | 3 | 5 | 3.0 | CCCC(=Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O)O | None | |||
| DB01193 | 250 | 60 | 125I-ICYP | -645 | 6 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 336 | 10 | 3 | 5 | 3.0 | CCCC(=Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O)O | None | |||
| 182585 | 15447 | 15 | 3H-5HT | -1 | 4 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 386 | 7 | 1 | 5 | 2.9 | O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COc2ccccc2O1 | None | |||
| CHEMBL12152 | 15447 | 15 | 3H-5HT | -1 | 4 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 386 | 7 | 1 | 5 | 2.9 | O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COc2ccccc2O1 | None | |||
| 2142 | 3096 | 58 | 125I-CYP | -741 | 36 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | |||
| 4920903 | 3096 | 58 | 125I-CYP | -741 | 36 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | |||
| 502 | 3096 | 58 | 125I-CYP | -741 | 36 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | |||
| 5775 | 3096 | 58 | 125I-CYP | -741 | 36 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | |||
| CHEMBL597 | 3096 | 58 | 125I-CYP | -741 | 36 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | |||
| DB00692 | 3096 | 58 | 125I-CYP | -741 | 36 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | |||
| 4106 | 2502 | 22 | 125I-ICYP | -102 | 34 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 5358812 | 2502 | 22 | 125I-ICYP | -102 | 34 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 89 | 2502 | 22 | 125I-ICYP | -102 | 34 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| CHEMBL93240 | 2502 | 22 | 125I-ICYP | -102 | 34 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 103 | 4153 | 61 | 3H-5CT | -48 | 53 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 2875 | 4153 | 61 | 3H-5CT | -48 | 53 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 5736 | 4153 | 61 | 3H-5CT | -48 | 53 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| CHEMBL285802 | 4153 | 61 | 3H-5CT | -48 | 53 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| DB09225 | 4153 | 61 | 3H-5CT | -48 | 53 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 1524 | 2181 | 96 | 3H-GR-125743 | -2511 | 52 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 197 | 2181 | 96 | 3H-GR-125743 | -2511 | 52 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 3822 | 2181 | 96 | 3H-GR-125743 | -2511 | 52 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 88 | 2181 | 96 | 3H-GR-125743 | -2511 | 52 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| CHEMBL51 | 2181 | 96 | 3H-GR-125743 | -2511 | 52 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| DB12465 | 2181 | 96 | 3H-GR-125743 | -2511 | 52 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 134 | 2514 | 24 | 3H-5HT | -251 | 67 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1775 | 2514 | 24 | 3H-5HT | -251 | 67 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 9681 | 2514 | 24 | 3H-5HT | -251 | 67 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| CHEMBL1065 | 2514 | 24 | 3H-5HT | -251 | 67 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| DB00247 | 2514 | 24 | 3H-5HT | -251 | 67 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 2543 | 3707 | 68 | 3H-5HT | -17 | 32 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | 3H-5HT | -17 | 32 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | 3H-5HT | -17 | 32 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | 3H-5HT | -17 | 32 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | 3H-5HT | -17 | 32 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 115 | 3791 | 80 | 125I-CYP | 1 | 27 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 4296 | 3791 | 80 | 125I-CYP | 1 | 27 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| CHEMBL274866 | 3791 | 80 | 125I-CYP | 1 | 27 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 2543 | 3707 | 68 | 3H-5HT | -17 | 32 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | 3H-5HT | -17 | 32 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | 3H-5HT | -17 | 32 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | 3H-5HT | -17 | 32 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | 3H-5HT | -17 | 32 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 44668 | 215942 | 0 | 3H-5HT | -1 | 4 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 228 | 3 | 2 | 1 | 3.1 | C1CNCCC1CCC2=CNC3=CC=CC=C32 | None | |||
| 138107169 | 215952 | 0 | 3H-5HT | -19054 | 22 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O | None | |||
| 22831402 | 215952 | 0 | 3H-5HT | -19054 | 22 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O | None | |||
| 2543 | 3707 | 68 | 125I-CYP | -17 | 32 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | 125I-CYP | -17 | 32 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | 125I-CYP | -17 | 32 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | 125I-CYP | -17 | 32 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | 125I-CYP | -17 | 32 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 2543 | 3707 | 68 | 3H-5HT | -17 | 32 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | 3H-5HT | -17 | 32 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | 3H-5HT | -17 | 32 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | 3H-5HT | -17 | 32 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | 3H-5HT | -17 | 32 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 115 | 3791 | 80 | 3H-5HT | 1 | 27 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 4296 | 3791 | 80 | 3H-5HT | 1 | 27 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| CHEMBL274866 | 3791 | 80 | 3H-5HT | 1 | 27 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 107 | 141 | 121 | 125I-ICYP | -30 | 30 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1833 | 141 | 121 | 125I-ICYP | -30 | 30 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| CHEMBL8165 | 141 | 121 | 125I-ICYP | -30 | 30 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 152662 | 215957 | 0 | 3H-5HT | 109 | 7 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 276 | 5 | 3 | 3 | 2.6 | CC1=CC2=C(N1)C=CC=C2OCC(CNC(C)(C)C)O | None | |||
| 24881687 | 172814 | 0 | UNDEFINED | -3 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 776 | 10 | 4 | 4 | 10.2 | O=C(Nc1ccc2[nH]cc(C3CCN(Cc4cccc(CN5CCC(c6c[nH]c7ccc(NC(=O)c8ccc(F)cc8)cc67)CC5)c4)CC3)c2c1)c1ccc(F)cc1 | None | |||
| CHEMBL451394 | 172814 | 0 | UNDEFINED | -3 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 776 | 10 | 4 | 4 | 10.2 | O=C(Nc1ccc2[nH]cc(C3CCN(Cc4cccc(CN5CCC(c6c[nH]c7ccc(NC(=O)c8ccc(F)cc8)cc67)CC5)c4)CC3)c2c1)c1ccc(F)cc1 | None | |||
| 138107169 | 215952 | 0 | 3H-5HT | -141 | 22 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O | None | |||
| 22831402 | 215952 | 0 | 3H-5HT | -141 | 22 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O | None | |||
| 165193 | 215945 | 0 | 125I-CYP | -154 | 30 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 165193 | 215945 | 0 | 3H-5HT | -154 | 30 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 62882 | 215945 | 0 | 125I-CYP | -154 | 30 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 62882 | 215945 | 0 | 3H-5HT | -154 | 30 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 66366 | 215945 | 0 | 125I-CYP | -154 | 30 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 66366 | 215945 | 0 | 3H-5HT | -154 | 30 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 2543 | 3707 | 68 | 125I-ICYP | -17 | 32 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 2543 | 3707 | 68 | 3H-5HT | -17 | 32 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | 125I-ICYP | -17 | 32 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | 3H-5HT | -17 | 32 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | 125I-ICYP | -17 | 32 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | 3H-5HT | -17 | 32 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | 125I-ICYP | -17 | 32 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | 3H-5HT | -17 | 32 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | 125I-ICYP | -17 | 32 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | 3H-5HT | -17 | 32 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 135 | 2532 | 43 | 3H-5HT | -851 | 58 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 1796 | 2532 | 43 | 3H-5HT | -851 | 58 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 4184 | 2532 | 43 | 3H-5HT | -851 | 58 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| CHEMBL6437 | 2532 | 43 | 3H-5HT | -851 | 58 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| DB06148 | 2532 | 43 | 3H-5HT | -851 | 58 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 2176 | 3127 | 68 | 3H-5HT | -741 | 27 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 4828 | 3127 | 68 | 3H-5HT | -741 | 27 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 91 | 3127 | 68 | 3H-5HT | -741 | 27 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| CHEMBL500 | 3127 | 68 | 3H-5HT | -741 | 27 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| DB00960 | 3127 | 68 | 3H-5HT | -741 | 27 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| None | 216341 | 0 | 3H-GR-125743 | -630 | 19 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 451 | 8 | 2 | 4 | 3.2 | CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C | None | |||
| 277 | 1301 | 62 | 125I-CYP | -501 | 50 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | |||
| 2913 | 1301 | 62 | 125I-CYP | -501 | 50 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | |||
| 765 | 1301 | 62 | 125I-CYP | -501 | 50 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | |||
| CHEMBL516 | 1301 | 62 | 125I-CYP | -501 | 50 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | |||
| DB00434 | 1301 | 62 | 125I-CYP | -501 | 50 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | |||
| 2470 | 3653 | 50 | 3H-5HT | -43651 | 59 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 3300 | 3653 | 50 | 3H-5HT | -43651 | 59 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 5265 | 3653 | 50 | 3H-5HT | -43651 | 59 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 99 | 3653 | 50 | 3H-5HT | -43651 | 59 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| CHEMBL267930 | 3653 | 50 | 3H-5HT | -43651 | 59 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 3198 | 205513 | 76 | None | -44 | 34 | Rat | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | None | |||
| CHEMBL1201049 | 205513 | 76 | None | -44 | 34 | Rat | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | None | |||
| CHEMBL808 | 205513 | 76 | None | -44 | 34 | Rat | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | None | |||
| 102 | 4127 | 48 | 3H-5HT | -64 | 49 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 3659 | 4127 | 48 | 3H-5HT | -64 | 49 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 8969 | 4127 | 48 | 3H-5HT | -64 | 49 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| CHEMBL15245 | 4127 | 48 | 3H-5HT | -64 | 49 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| DB01392 | 4127 | 48 | 3H-5HT | -64 | 49 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 165193 | 215945 | 0 | 3H-5HT | -154 | 30 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 62882 | 215945 | 0 | 3H-5HT | -154 | 30 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 66366 | 215945 | 0 | 3H-5HT | -154 | 30 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 102 | 4127 | 48 | 3H-5HT | -64 | 49 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 3659 | 4127 | 48 | 3H-5HT | -64 | 49 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 8969 | 4127 | 48 | 3H-5HT | -64 | 49 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| CHEMBL15245 | 4127 | 48 | 3H-5HT | -64 | 49 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| DB01392 | 4127 | 48 | 3H-5HT | -64 | 49 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 165193 | 215945 | 0 | 3H-5HT | -154 | 30 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 62882 | 215945 | 0 | 3H-5HT | -154 | 30 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 66366 | 215945 | 0 | 3H-5HT | -154 | 30 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 4189 | 206922 | 96 | None | -41 | 34 | Rat | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | None | |||
| CHEMBL1559 | 206922 | 96 | None | -41 | 34 | Rat | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | None | |||
| CHEMBL91 | 206922 | 96 | None | -41 | 34 | Rat | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | None | |||
| 1884 | 2735 | 58 | 3H-GR-125743 | -3 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | None | |||
| 4440 | 2735 | 58 | 3H-GR-125743 | -3 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | None | |||
| 45 | 2735 | 58 | 3H-GR-125743 | -3 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | None | |||
| CHEMBL1278 | 2735 | 58 | 3H-GR-125743 | -3 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | None | |||
| DB00952 | 2735 | 58 | 3H-GR-125743 | -3 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | None | |||
| 1809 | 134 | 32 | 3H-5HT | -15 | 36 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-5HT | -15 | 36 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-5HT | -15 | 36 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 1809 | 134 | 32 | 125I-CYP | -32 | 36 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 1809 | 134 | 32 | 3H-5HT | -32 | 36 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 125I-CYP | -32 | 36 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-5HT | -32 | 36 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 125I-CYP | -32 | 36 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-5HT | -32 | 36 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 46780481 | 107531 | 20 | 3H-GR-125743 | -32 | 53 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| 9903970 | 107531 | 20 | 3H-GR-125743 | -32 | 53 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| CHEMBL3187365 | 107531 | 20 | 3H-GR-125743 | -32 | 53 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| CHEMBL3544974 | 107531 | 20 | 3H-GR-125743 | -32 | 53 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| 3823 | 50221 | 42 | None | -38 | 10 | Rat | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 530 | 7 | 0 | 7 | 4.2 | CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | None | |||
| 76973198 | 50221 | 42 | None | -38 | 10 | Rat | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 530 | 7 | 0 | 7 | 4.2 | CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | None | |||
| CHEMBL157101 | 50221 | 42 | None | -38 | 10 | Rat | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 530 | 7 | 0 | 7 | 4.2 | CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | None | |||
| 5 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 133 | 2496 | 52 | 3H-5HT | -23 | 42 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 1723 | 2496 | 52 | 3H-5HT | -23 | 42 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 28693 | 2496 | 52 | 3H-5HT | -23 | 42 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| CHEMBL19215 | 2496 | 52 | 3H-5HT | -23 | 42 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| DB13520 | 2496 | 52 | 3H-5HT | -23 | 42 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 132 | 1275 | 13 | 125I-CYP | -54 | 15 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| 155346 | 1275 | 13 | 125I-CYP | -54 | 15 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| CHEMBL378501 | 1275 | 13 | 125I-CYP | -54 | 15 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| 2470 | 3653 | 50 | None | -43651 | 59 | Rat | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 3300 | 3653 | 50 | None | -43651 | 59 | Rat | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 5265 | 3653 | 50 | None | -43651 | 59 | Rat | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 99 | 3653 | 50 | None | -43651 | 59 | Rat | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| CHEMBL267930 | 3653 | 50 | None | -43651 | 59 | Rat | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 135 | 2532 | 43 | None | -851 | 58 | Rat | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 1796 | 2532 | 43 | None | -851 | 58 | Rat | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 4184 | 2532 | 43 | None | -851 | 58 | Rat | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| CHEMBL6437 | 2532 | 43 | None | -851 | 58 | Rat | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| DB06148 | 2532 | 43 | None | -851 | 58 | Rat | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 5 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 4595 | 176715 | 106 | None | -7 | 15 | Rat | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 293 | 2 | 0 | 4 | 3.1 | Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O | None | |||
| CHEMBL46 | 176715 | 106 | None | -7 | 15 | Rat | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 293 | 2 | 0 | 4 | 3.1 | Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O | None | |||
| 446220 | 133521 | 14 | None | -23 | 45 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 303 | 3 | 0 | 5 | 1.9 | COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C | None | |||
| CHEMBL370805 | 133521 | 14 | None | -23 | 45 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 303 | 3 | 0 | 5 | 1.9 | COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C | None | |||
| 133 | 2496 | 52 | 3H-GR-125743 | -23 | 42 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 1723 | 2496 | 52 | 3H-GR-125743 | -23 | 42 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 28693 | 2496 | 52 | 3H-GR-125743 | -23 | 42 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| CHEMBL19215 | 2496 | 52 | 3H-GR-125743 | -23 | 42 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| DB13520 | 2496 | 52 | 3H-GR-125743 | -23 | 42 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 3117 | 207841 | 103 | None | -3 | 16 | Rat | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 296 | 4 | 0 | 4 | 3.6 | CCN(CC)C(=S)SSC(=S)N(CC)CC | None | |||
| CHEMBL964 | 207841 | 103 | None | -3 | 16 | Rat | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 296 | 4 | 0 | 4 | 3.6 | CCN(CC)C(=S)SSC(=S)N(CC)CC | None | |||
| 4106 | 2502 | 22 | 3H-GR-125743 | -11 | 34 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 5358812 | 2502 | 22 | 3H-GR-125743 | -11 | 34 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 89 | 2502 | 22 | 3H-GR-125743 | -11 | 34 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| CHEMBL93240 | 2502 | 22 | 3H-GR-125743 | -11 | 34 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 1524 | 2181 | 96 | None | -512 | 52 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 197 | 2181 | 96 | None | -512 | 52 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 3822 | 2181 | 96 | None | -512 | 52 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 88 | 2181 | 96 | None | -512 | 52 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| CHEMBL51 | 2181 | 96 | None | -512 | 52 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| DB12465 | 2181 | 96 | None | -512 | 52 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 66265 | 94013 | 15 | None | -1 | 19 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 231 | 4 | 1 | 1 | 3.2 | CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1 | None | |||
| CHEMBL248702 | 94013 | 15 | None | -1 | 19 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 231 | 4 | 1 | 1 | 3.2 | CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1 | None | |||
| 2726 | 919 | 68 | None | -147 | 72 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 621 | 919 | 68 | None | -147 | 72 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 83 | 919 | 68 | None | -147 | 72 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| CHEMBL71 | 919 | 68 | None | -147 | 72 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| DB00477 | 919 | 68 | None | -147 | 72 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 2605 | 3783 | 30 | 3H-GR-125743 | -7 | 10 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 295 | 5 | 2 | 4 | 2.9 | OC(COc1cccc2c1SCCC2)CNC(C)(C)C | None | |||
| 36920 | 3783 | 30 | 3H-GR-125743 | -7 | 10 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 295 | 5 | 2 | 4 | 2.9 | OC(COc1cccc2c1SCCC2)CNC(C)(C)C | None | |||
| 571 | 3783 | 30 | 3H-GR-125743 | -7 | 10 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 295 | 5 | 2 | 4 | 2.9 | OC(COc1cccc2c1SCCC2)CNC(C)(C)C | None | |||
| CHEMBL434200 | 3783 | 30 | 3H-GR-125743 | -7 | 10 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 295 | 5 | 2 | 4 | 2.9 | OC(COc1cccc2c1SCCC2)CNC(C)(C)C | None | |||
| DB13775 | 3783 | 30 | 3H-GR-125743 | -7 | 10 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 295 | 5 | 2 | 4 | 2.9 | OC(COc1cccc2c1SCCC2)CNC(C)(C)C | None | |||
| 180 | 401 | 56 | None | -389 | 40 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | |||
| 200 | 401 | 56 | None | -389 | 40 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | |||
| 2160 | 401 | 56 | None | -389 | 40 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | |||
| CHEMBL629 | 401 | 56 | None | -389 | 40 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | |||
| DB00321 | 401 | 56 | None | -389 | 40 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | |||
| 2337 | 3256 | 77 | None | -26 | 62 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 50 | 3256 | 77 | None | -26 | 62 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 5002 | 3256 | 77 | None | -26 | 62 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| CHEMBL716 | 3256 | 77 | None | -26 | 62 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| DB01224 | 3256 | 77 | None | -26 | 62 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 2726 | 919 | 68 | None | -54 | 72 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 621 | 919 | 68 | None | -54 | 72 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 83 | 919 | 68 | None | -54 | 72 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| CHEMBL71 | 919 | 68 | None | -54 | 72 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| DB00477 | 919 | 68 | None | -54 | 72 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 1971 | 2866 | 38 | None | -18 | 30 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | None | |||
| 2404 | 2866 | 38 | None | -18 | 30 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | None | |||
| 4543 | 2866 | 38 | None | -18 | 30 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | None | |||
| CHEMBL445 | 2866 | 38 | None | -18 | 30 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | None | |||
| DB00540 | 2866 | 38 | None | -18 | 30 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | None | |||
| 3191 | 102858 | 97 | None | -17 | 25 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | None | |||
| CHEMBL305660 | 102858 | 97 | None | -17 | 25 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | None | |||
| 6761 | 67799 | 19 | None | -43 | 18 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 401 | 5 | 1 | 4 | 4.5 | NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 | None | |||
| CHEMBL1909072 | 67799 | 19 | None | -43 | 18 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 401 | 5 | 1 | 4 | 4.5 | NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 | None | |||
| 277 | 1301 | 62 | None | -501 | 50 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | |||
| 2913 | 1301 | 62 | None | -501 | 50 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | |||
| 765 | 1301 | 62 | None | -501 | 50 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | |||
| CHEMBL516 | 1301 | 62 | None | -501 | 50 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | |||
| DB00434 | 1301 | 62 | None | -501 | 50 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | |||
| 2274 | 3173 | 58 | None | -39 | 31 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | |||
| 4917 | 3173 | 58 | None | -39 | 31 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | |||
| 7279 | 3173 | 58 | None | -39 | 31 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | |||
| CHEMBL728 | 3173 | 58 | None | -39 | 31 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | |||
| DB00433 | 3173 | 58 | None | -39 | 31 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | |||
| 1222 | 1664 | 49 | None | -134 | 33 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 3396 | 1664 | 49 | None | -134 | 33 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 85 | 1664 | 49 | None | -134 | 33 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| CHEMBL46516 | 1664 | 49 | None | -134 | 33 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| DB04842 | 1664 | 49 | None | -134 | 33 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 4106 | 2502 | 22 | 3H-5HT | -102 | 34 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 5358812 | 2502 | 22 | 3H-5HT | -102 | 34 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 89 | 2502 | 22 | 3H-5HT | -102 | 34 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| CHEMBL93240 | 2502 | 22 | 3H-5HT | -102 | 34 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 102 | 4127 | 48 | 3H-5CT | -125 | 49 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 3659 | 4127 | 48 | 3H-5CT | -125 | 49 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 8969 | 4127 | 48 | 3H-5CT | -125 | 49 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| CHEMBL15245 | 4127 | 48 | 3H-5CT | -125 | 49 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| DB01392 | 4127 | 48 | 3H-5CT | -125 | 49 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 3652 | 4097 | 79 | 3H-5HT | -3 | 18 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| 57 | 4097 | 79 | 3H-5HT | -3 | 18 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| 60809 | 4097 | 79 | 3H-5HT | -3 | 18 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| CHEMBL21536 | 4097 | 79 | 3H-5HT | -3 | 18 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| DB15357 | 4097 | 79 | 3H-5HT | -3 | 18 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| 1222 | 1664 | 49 | 3H-5HT | -8317 | 33 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 3396 | 1664 | 49 | 3H-5HT | -8317 | 33 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 85 | 1664 | 49 | 3H-5HT | -8317 | 33 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| CHEMBL46516 | 1664 | 49 | 3H-5HT | -8317 | 33 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| DB04842 | 1664 | 49 | 3H-5HT | -8317 | 33 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 1353 | 1911 | 93 | 3H-5HT | -5248 | 83 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 3559 | 1911 | 93 | 3H-5HT | -5248 | 83 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 86 | 1911 | 93 | 3H-5HT | -5248 | 83 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| CHEMBL54 | 1911 | 93 | 3H-5HT | -5248 | 83 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| DB00502 | 1911 | 93 | 3H-5HT | -5248 | 83 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 2337 | 3256 | 77 | 3H-5HT | -575 | 62 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 50 | 3256 | 77 | 3H-5HT | -575 | 62 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 5002 | 3256 | 77 | 3H-5HT | -575 | 62 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| CHEMBL716 | 3256 | 77 | 3H-5HT | -575 | 62 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| DB01224 | 3256 | 77 | 3H-5HT | -575 | 62 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 2435 | 3590 | 83 | 3H-5CT | -128 | 48 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 60149 | 3590 | 83 | 3H-5CT | -128 | 48 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 98 | 3590 | 83 | 3H-5CT | -128 | 48 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| CHEMBL12713 | 3590 | 83 | 3H-5CT | -128 | 48 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| DB06144 | 3590 | 83 | 3H-5CT | -128 | 48 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 7153 | 98020 | 77 | 3H-5HT | -11 | 34 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | |||
| CHEMBL272942 | 98020 | 77 | 3H-5HT | -11 | 34 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | |||
| 68604 | 78205 | 29 | 125I-CYP | -11748 | 6 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 401 | 5 | 0 | 6 | 2.9 | Cc1nc2n(c(=O)c1CCN1CCC(C(=O)c3ccc(F)cc3)CC1)CCS2 | None | |||
| CHEMBL2105437 | 78205 | 29 | 125I-CYP | -11748 | 6 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 401 | 5 | 0 | 6 | 2.9 | Cc1nc2n(c(=O)c1CCN1CCC(C(=O)c3ccc(F)cc3)CC1)CCS2 | None | |||
| 135398745 | 2914 | 112 | 3H-GR-125743 | -199 | 65 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| 47 | 2914 | 112 | 3H-GR-125743 | -199 | 65 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| CHEMBL715 | 2914 | 112 | 3H-GR-125743 | -199 | 65 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| DB00334 | 2914 | 112 | 3H-GR-125743 | -199 | 65 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| 1574 | 81 | 60 | 3H-5HT | -8 | 21 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | None | |||
| 218 | 81 | 60 | 3H-5HT | -8 | 21 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | None | |||
| CHEMBL266591 | 81 | 60 | 3H-5HT | -8 | 21 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | None | |||
| 2176 | 3127 | 68 | 125I-CYP | -741 | 27 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 4828 | 3127 | 68 | 125I-CYP | -741 | 27 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 91 | 3127 | 68 | 125I-CYP | -741 | 27 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| CHEMBL500 | 3127 | 68 | 125I-CYP | -741 | 27 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| DB00960 | 3127 | 68 | 125I-CYP | -741 | 27 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 10257 | 738 | 31 | 3H-5HT | -141 | 19 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 204 | 3 | 2 | 2 | 2.0 | CN(CCc1c[nH]c2c1cc(O)cc2)C | None | |||
| 144 | 738 | 31 | 3H-5HT | -141 | 19 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 204 | 3 | 2 | 2 | 2.0 | CN(CCc1c[nH]c2c1cc(O)cc2)C | None | |||
| CHEMBL416526 | 738 | 31 | 3H-5HT | -141 | 19 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 204 | 3 | 2 | 2 | 2.0 | CN(CCc1c[nH]c2c1cc(O)cc2)C | None | |||
| DB01445 | 738 | 31 | 3H-5HT | -141 | 19 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 204 | 3 | 2 | 2 | 2.0 | CN(CCc1c[nH]c2c1cc(O)cc2)C | None | |||
| 133 | 2496 | 52 | 3H-5HT | -40 | 42 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 1723 | 2496 | 52 | 3H-5HT | -40 | 42 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 28693 | 2496 | 52 | 3H-5HT | -40 | 42 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| CHEMBL19215 | 2496 | 52 | 3H-5HT | -40 | 42 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| DB13520 | 2496 | 52 | 3H-5HT | -40 | 42 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 103 | 4153 | 61 | 3H-Alniditan | -48 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 2875 | 4153 | 61 | 3H-Alniditan | -48 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 5736 | 4153 | 61 | 3H-Alniditan | -48 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| CHEMBL285802 | 4153 | 61 | 3H-Alniditan | -48 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| DB09225 | 4153 | 61 | 3H-Alniditan | -48 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 3025067 | 99382 | 64 | 3H-5HT | -2 | 15 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 220 | 1 | 1 | 4 | 0.9 | c1cc2c(c(N3CCNCC3)c1)OCCO2 | None | |||
| 65853 | 99382 | 64 | 3H-5HT | -2 | 15 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 220 | 1 | 1 | 4 | 0.9 | c1cc2c(c(N3CCNCC3)c1)OCCO2 | None | |||
| CHEMBL282614 | 99382 | 64 | 3H-5HT | -2 | 15 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 220 | 1 | 1 | 4 | 0.9 | c1cc2c(c(N3CCNCC3)c1)OCCO2 | None | |||
| 4106 | 2502 | 22 | 125I-CYP | -102 | 34 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 5358812 | 2502 | 22 | 125I-CYP | -102 | 34 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 89 | 2502 | 22 | 125I-CYP | -102 | 34 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| CHEMBL93240 | 2502 | 22 | 125I-CYP | -102 | 34 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 4106 | 2502 | 22 | 125I-CYP | -102 | 34 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 5358812 | 2502 | 22 | 125I-CYP | -102 | 34 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 89 | 2502 | 22 | 125I-CYP | -102 | 34 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| CHEMBL93240 | 2502 | 22 | 125I-CYP | -102 | 34 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 134 | 2514 | 24 | 3H-5HT | -251 | 67 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1775 | 2514 | 24 | 3H-5HT | -251 | 67 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 9681 | 2514 | 24 | 3H-5HT | -251 | 67 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| CHEMBL1065 | 2514 | 24 | 3H-5HT | -251 | 67 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| DB00247 | 2514 | 24 | 3H-5HT | -251 | 67 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 2435 | 3590 | 83 | 3H-5HT | -1023 | 48 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 60149 | 3590 | 83 | 3H-5HT | -1023 | 48 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 98 | 3590 | 83 | 3H-5HT | -1023 | 48 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| CHEMBL12713 | 3590 | 83 | 3H-5HT | -1023 | 48 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| DB06144 | 3590 | 83 | 3H-5HT | -1023 | 48 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 1150 | 3878 | 121 | 3H-5HT | -7 | 25 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | |||
| 125 | 3878 | 121 | 3H-5HT | -7 | 25 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | |||
| CHEMBL6640 | 3878 | 121 | 3H-5HT | -7 | 25 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | |||
| DB08653 | 3878 | 121 | 3H-5HT | -7 | 25 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | |||
| 2389 | 3331 | 118 | 3H-GR-125743 | -93 | 67 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 5073 | 3331 | 118 | 3H-GR-125743 | -93 | 67 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 96 | 3331 | 118 | 3H-GR-125743 | -93 | 67 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| CHEMBL85 | 3331 | 118 | 3H-GR-125743 | -93 | 67 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| DB00734 | 3331 | 118 | 3H-GR-125743 | -93 | 67 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 3025067 | 99382 | 64 | 3H-5HT | -2 | 15 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 220 | 1 | 1 | 4 | 0.9 | c1cc2c(c(N3CCNCC3)c1)OCCO2 | None | |||
| 65853 | 99382 | 64 | 3H-5HT | -2 | 15 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 220 | 1 | 1 | 4 | 0.9 | c1cc2c(c(N3CCNCC3)c1)OCCO2 | None | |||
| CHEMBL282614 | 99382 | 64 | 3H-5HT | -2 | 15 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 220 | 1 | 1 | 4 | 0.9 | c1cc2c(c(N3CCNCC3)c1)OCCO2 | None | |||
| 2470 | 3653 | 50 | 125I-CYP | -43651 | 59 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 2470 | 3653 | 50 | 3H-5HT | -43651 | 59 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 3300 | 3653 | 50 | 125I-CYP | -43651 | 59 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 3300 | 3653 | 50 | 3H-5HT | -43651 | 59 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 5265 | 3653 | 50 | 125I-CYP | -43651 | 59 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 5265 | 3653 | 50 | 3H-5HT | -43651 | 59 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 99 | 3653 | 50 | 125I-CYP | -43651 | 59 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 99 | 3653 | 50 | 3H-5HT | -43651 | 59 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| CHEMBL267930 | 3653 | 50 | 125I-CYP | -43651 | 59 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| CHEMBL267930 | 3653 | 50 | 3H-5HT | -43651 | 59 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 115 | 3791 | 80 | 125I-ICYP | 1 | 27 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 4296 | 3791 | 80 | 125I-ICYP | 1 | 27 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| CHEMBL274866 | 3791 | 80 | 125I-ICYP | 1 | 27 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 2337 | 3256 | 77 | 3H-5HT | -575 | 62 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 50 | 3256 | 77 | 3H-5HT | -575 | 62 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 5002 | 3256 | 77 | 3H-5HT | -575 | 62 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| CHEMBL716 | 3256 | 77 | 3H-5HT | -575 | 62 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| DB01224 | 3256 | 77 | 3H-5HT | -575 | 62 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 18971832 | 2418 | 0 | 3H-5HT | -85 | 13 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 351 | 3 | 2 | 2 | 4.0 | CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C | None | |||
| 21 | 2418 | 0 | 3H-5HT | -85 | 13 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 351 | 3 | 2 | 2 | 4.0 | CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C | None | |||
| CHEMBL3186179 | 2418 | 0 | 3H-5HT | -85 | 13 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 351 | 3 | 2 | 2 | 4.0 | CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C | None | |||
| 46780481 | 107531 | 20 | 3H-5HT | -363 | 53 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| 9903970 | 107531 | 20 | 3H-5HT | -363 | 53 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| CHEMBL3187365 | 107531 | 20 | 3H-5HT | -363 | 53 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| CHEMBL3544974 | 107531 | 20 | 3H-5HT | -363 | 53 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| 4106 | 2502 | 22 | 125I-ICYP | -102 | 34 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 5358812 | 2502 | 22 | 125I-ICYP | -102 | 34 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 89 | 2502 | 22 | 125I-ICYP | -102 | 34 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| CHEMBL93240 | 2502 | 22 | 125I-ICYP | -102 | 34 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 132 | 1275 | 13 | 125I-CYP | -54 | 15 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| 155346 | 1275 | 13 | 125I-CYP | -54 | 15 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| CHEMBL378501 | 1275 | 13 | 125I-CYP | -54 | 15 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | None | |||
| 2303 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 4946 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 564 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 63 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 91536 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| CHEMBL27 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| CHEMBL452861 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| DB00571 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 165193 | 215945 | 0 | 125I-ICYP | -154 | 30 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 62882 | 215945 | 0 | 125I-ICYP | -154 | 30 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 66366 | 215945 | 0 | 125I-ICYP | -154 | 30 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 283 | 3130 | 57 | 125I-CYP | -6606 | 12 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 393 | 5 | 0 | 5 | 3.3 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2 | None | |||
| 4847 | 3130 | 57 | 125I-CYP | -6606 | 12 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 393 | 5 | 0 | 5 | 3.3 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2 | None | |||
| CHEMBL18331 | 3130 | 57 | 125I-CYP | -6606 | 12 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 393 | 5 | 0 | 5 | 3.3 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2 | None | |||
| 165193 | 215945 | 0 | 125I-ICYP | -154 | 30 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 62882 | 215945 | 0 | 125I-ICYP | -154 | 30 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 66366 | 215945 | 0 | 125I-ICYP | -154 | 30 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 5074 | 3332 | 80 | 125I-ICYP | -4168 | 30 | Rat | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | None | |||
| 97 | 3332 | 80 | 125I-ICYP | -4168 | 30 | Rat | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | None | |||
| CHEMBL267777 | 3332 | 80 | 125I-ICYP | -4168 | 30 | Rat | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | None | |||
| DB12693 | 3332 | 80 | 125I-ICYP | -4168 | 30 | Rat | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | None | |||
| 5475158 | 67213 | 25 | 125I-CYP | -1023 | 14 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 340 | 8 | 1 | 3 | 4.4 | CN(C)CCCSc1ccccc1NC(=O)/C=C/c1ccccc1 | None | |||
| CHEMBL18786 | 67213 | 25 | 125I-CYP | -1023 | 14 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 340 | 8 | 1 | 3 | 4.4 | CN(C)CCCSc1ccccc1NC(=O)/C=C/c1ccccc1 | None | |||
| 2865 | 4143 | 73 | 3H-5CT | -12 | 53 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| 59 | 4143 | 73 | 3H-5CT | -12 | 53 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| 60854 | 4143 | 73 | 3H-5CT | -12 | 53 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| CHEMBL708 | 4143 | 73 | 3H-5CT | -12 | 53 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| DB00246 | 4143 | 73 | 3H-5CT | -12 | 53 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| 2176 | 3127 | 68 | 125I-ICYP | -741 | 27 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 4828 | 3127 | 68 | 125I-ICYP | -741 | 27 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 91 | 3127 | 68 | 125I-ICYP | -741 | 27 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| CHEMBL500 | 3127 | 68 | 125I-ICYP | -741 | 27 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| DB00960 | 3127 | 68 | 125I-ICYP | -741 | 27 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 2176 | 3127 | 68 | 125I-ICYP | -741 | 27 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 4828 | 3127 | 68 | 125I-ICYP | -741 | 27 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 91 | 3127 | 68 | 125I-ICYP | -741 | 27 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| CHEMBL500 | 3127 | 68 | 125I-ICYP | -741 | 27 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| DB00960 | 3127 | 68 | 125I-ICYP | -741 | 27 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 1809 | 134 | 32 | 3H-GR-125743 | -15 | 36 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-GR-125743 | -15 | 36 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-GR-125743 | -15 | 36 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 107780 | 1844 | 54 | 3H-GR-125743 | -4 | 17 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 14 | 1844 | 54 | 3H-GR-125743 | -4 | 17 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| CHEMBL15928 | 1844 | 54 | 3H-GR-125743 | -4 | 17 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 1212 | 1662 | 50 | None | -144 | 65 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
| 204 | 1662 | 50 | None | -144 | 65 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
| 3372 | 1662 | 50 | None | -144 | 65 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
| CHEMBL726 | 1662 | 50 | None | -144 | 65 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
| DB00623 | 1662 | 50 | None | -144 | 65 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
| 2351 | 3286 | 64 | None | -10 | 21 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 473 | 7 | 2 | 6 | 6.1 | Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O | None | |||
| 2820 | 3286 | 64 | None | -10 | 21 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 473 | 7 | 2 | 6 | 6.1 | Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O | None | |||
| 5035 | 3286 | 64 | None | -10 | 21 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 473 | 7 | 2 | 6 | 6.1 | Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O | None | |||
| CHEMBL81 | 3286 | 64 | None | -10 | 21 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 473 | 7 | 2 | 6 | 6.1 | Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O | None | |||
| DB00481 | 3286 | 64 | None | -10 | 21 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 473 | 7 | 2 | 6 | 6.1 | Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O | None | |||
| 213 | 3853 | 55 | None | -6 | 44 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | |||
| 2717 | 3853 | 55 | None | -6 | 44 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | |||
| 5533 | 3853 | 55 | None | -6 | 44 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | |||
| CHEMBL621 | 3853 | 55 | None | -6 | 44 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | |||
| DB00656 | 3853 | 55 | None | -6 | 44 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | |||
| 242 | 470 | 124 | None | -380 | 51 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| 34 | 470 | 124 | None | -380 | 51 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| 60795 | 470 | 124 | None | -380 | 51 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| CHEMBL1112 | 470 | 124 | None | -380 | 51 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| DB01238 | 470 | 124 | None | -380 | 51 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| 49831411 | 217746 | 0 | None | 1 | 15 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 659 | 19 | 0 | 6 | 8.7 | CCCCCCCCCCCC(=O)OCN1C(=O)CCC2=CC=C(OCCCCN3CCN(CC3)C3=C(Cl)C(Cl)=CC=C3)C=C12 | None | |||
| 2247 | 505 | 81 | None | -35 | 42 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | |||
| 249 | 505 | 81 | None | -35 | 42 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | |||
| 2603 | 505 | 81 | None | -35 | 42 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | |||
| CHEMBL296419 | 505 | 81 | None | -35 | 42 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | |||
| DB00637 | 505 | 81 | None | -35 | 42 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | |||
| 135398737 | 958 | 93 | None | -151 | 89 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 38 | 958 | 93 | None | -151 | 89 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 722 | 958 | 93 | None | -151 | 89 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| CHEMBL42 | 958 | 93 | None | -151 | 89 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| DB00363 | 958 | 93 | None | -151 | 89 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 2181 | 3128 | 46 | None | -70 | 35 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| 4830 | 3128 | 46 | None | -70 | 35 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| 92 | 3128 | 46 | None | -70 | 35 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| CHEMBL440294 | 3128 | 46 | None | -70 | 35 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| DB09286 | 3128 | 46 | None | -70 | 35 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| 2303 | 3187 | 68 | None | -1174 | 26 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 4946 | 3187 | 68 | None | -1174 | 26 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 564 | 3187 | 68 | None | -1174 | 26 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 63 | 3187 | 68 | None | -1174 | 26 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 91536 | 3187 | 68 | None | -1174 | 26 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| CHEMBL27 | 3187 | 68 | None | -1174 | 26 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| CHEMBL452861 | 3187 | 68 | None | -1174 | 26 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| DB00571 | 3187 | 68 | None | -1174 | 26 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 2585 | 803 | 103 | None | -100 | 21 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | None | |||
| 522 | 803 | 103 | None | -100 | 21 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | None | |||
| 551 | 803 | 103 | None | -100 | 21 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | None | |||
| CHEMBL723 | 803 | 103 | None | -100 | 21 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | None | |||
| DB01136 | 803 | 103 | None | -100 | 21 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | None | |||
| 135398745 | 2914 | 112 | None | -199 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| 47 | 2914 | 112 | None | -199 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| CHEMBL715 | 2914 | 112 | None | -199 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| DB00334 | 2914 | 112 | None | -199 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| 37 | 778 | 60 | None | -22 | 17 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | None | |||
| 460 | 778 | 60 | None | -22 | 17 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | None | |||
| 54746 | 778 | 60 | None | -22 | 17 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | None | |||
| CHEMBL1201087 | 778 | 60 | None | -22 | 17 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | None | |||
| DB00248 | 778 | 60 | None | -22 | 17 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | None | |||
| 135398745 | 2914 | 112 | None | -162 | 65 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| 47 | 2914 | 112 | None | -162 | 65 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| CHEMBL715 | 2914 | 112 | None | -162 | 65 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| DB00334 | 2914 | 112 | None | -162 | 65 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| 1613 | 2348 | 53 | None | -13 | 44 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
| 205 | 2348 | 53 | None | -13 | 44 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
| 3964 | 2348 | 53 | None | -13 | 44 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
| CHEMBL831 | 2348 | 53 | None | -13 | 44 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
| DB00408 | 2348 | 53 | None | -13 | 44 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
| 1212 | 1662 | 50 | None | -93 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
| 204 | 1662 | 50 | None | -93 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
| 3372 | 1662 | 50 | None | -93 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
| CHEMBL726 | 1662 | 50 | None | -93 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
| DB00623 | 1662 | 50 | None | -93 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
| 3389 | 217711 | 0 | None | -1 | 26 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 549 | 12 | 0 | 6 | 6.8 | CCCCCCC(=O)OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1 | None | |||
| 31101 | 729 | 40 | None | -128 | 36 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
| 35 | 729 | 40 | None | -128 | 36 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
| 403 | 729 | 40 | None | -128 | 36 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
| CHEMBL493 | 729 | 40 | None | -128 | 36 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
| DB01200 | 729 | 40 | None | -128 | 36 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
| 1353 | 1911 | 93 | None | -66 | 83 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 3559 | 1911 | 93 | None | -66 | 83 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 86 | 1911 | 93 | None | -66 | 83 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| CHEMBL54 | 1911 | 93 | None | -66 | 83 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| DB00502 | 1911 | 93 | None | -66 | 83 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 2601 | 3780 | 33 | None | -87 | 21 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 443951 | 3780 | 33 | None | -87 | 21 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 56 | 3780 | 33 | None | -87 | 21 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| CHEMBL73151 | 3780 | 33 | None | -87 | 21 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| DB13399 | 3780 | 33 | None | -87 | 21 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 1621 | 2429 | 17 | 3H-5HT | -97 | 45 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 17 | 2429 | 17 | 3H-5HT | -97 | 45 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 5761 | 2429 | 17 | 3H-5HT | -97 | 45 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| CHEMBL263881 | 2429 | 17 | 3H-5HT | -97 | 45 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| DB04829 | 2429 | 17 | 3H-5HT | -97 | 45 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 26987 | 949 | 33 | None | -138 | 21 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | None | |||
| 6063 | 949 | 33 | None | -138 | 21 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | None | |||
| 671 | 949 | 33 | None | -138 | 21 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | None | |||
| CHEMBL1626 | 949 | 33 | None | -138 | 21 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | None | |||
| DB00283 | 949 | 33 | None | -138 | 21 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | None | |||
| 212 | 3806 | 47 | None | -6 | 25 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | None | |||
| 2639 | 3806 | 47 | None | -6 | 25 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | None | |||
| 941651 | 3806 | 47 | None | -6 | 25 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | None | |||
| CHEMBL1201 | 3806 | 47 | None | -6 | 25 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | None | |||
| DB01623 | 3806 | 47 | None | -6 | 25 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | None | |||
| 2393 | 3334 | 82 | None | -1 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | None | |||
| 5078 | 3334 | 82 | None | -1 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | None | |||
| 51 | 3334 | 82 | None | -1 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | None | |||
| CHEMBL905 | 3334 | 82 | None | -1 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | None | |||
| DB00953 | 3334 | 82 | None | -1 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | None | |||
| 130 | 3500 | 47 | 35S-GTPGammaS | -1 | 13 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 3378093 | 3500 | 47 | 35S-GTPGammaS | -1 | 13 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| CHEMBL281350 | 3500 | 47 | 35S-GTPGammaS | -1 | 13 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 100 | 3805 | 58 | None | -13 | 55 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
| 2637 | 3805 | 58 | None | -13 | 55 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
| 5452 | 3805 | 58 | None | -13 | 55 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
| CHEMBL479 | 3805 | 58 | None | -13 | 55 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
| DB00679 | 3805 | 58 | None | -13 | 55 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
| 134 | 2514 | 24 | None | -251 | 67 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1775 | 2514 | 24 | None | -251 | 67 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 9681 | 2514 | 24 | None | -251 | 67 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| CHEMBL1065 | 2514 | 24 | None | -251 | 67 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| DB00247 | 2514 | 24 | None | -251 | 67 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 2435 | 3590 | 83 | 3H-Alniditan | -128 | 48 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 60149 | 3590 | 83 | 3H-Alniditan | -128 | 48 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 98 | 3590 | 83 | 3H-Alniditan | -128 | 48 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| CHEMBL12713 | 3590 | 83 | 3H-Alniditan | -128 | 48 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| DB06144 | 3590 | 83 | 3H-Alniditan | -128 | 48 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 2543 | 3707 | 68 | 3H-GR-125743 | -3 | 32 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | 3H-GR-125743 | -3 | 32 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | 3H-GR-125743 | -3 | 32 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | 3H-GR-125743 | -3 | 32 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | 3H-GR-125743 | -3 | 32 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 115 | 3791 | 80 | 3H-5HT | 1 | 27 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 4296 | 3791 | 80 | 3H-5HT | 1 | 27 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| CHEMBL274866 | 3791 | 80 | 3H-5HT | 1 | 27 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 182595 | 19937 | 14 | 3H-5HT | -1000 | 4 | Rat | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 350 | 4 | 0 | 4 | 3.3 | c1ccc2c(c1)CC2CCN1CCN(c2cccc3c2OCCO3)CC1 | None | |||
| CHEMBL130276 | 19937 | 14 | 3H-5HT | -1000 | 4 | Rat | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 350 | 4 | 0 | 4 | 3.3 | c1ccc2c(c1)CC2CCN1CCN(c2cccc3c2OCCO3)CC1 | None | |||
| 1220 | 187 | 55 | 125I-CYP | -7413 | 44 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 31 | 187 | 55 | 125I-CYP | -7413 | 44 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 7 | 187 | 55 | 125I-CYP | -7413 | 44 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| CHEMBL56 | 187 | 55 | 125I-CYP | -7413 | 44 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 3151 | 1462 | 97 | 125I-CYP | -7762 | 27 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 425 | 5 | 2 | 5 | 3.4 | Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 | None | |||
| 945 | 1462 | 97 | 125I-CYP | -7762 | 27 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 425 | 5 | 2 | 5 | 3.4 | Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 | None | |||
| 965 | 1462 | 97 | 125I-CYP | -7762 | 27 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 425 | 5 | 2 | 5 | 3.4 | Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 | None | |||
| CHEMBL219916 | 1462 | 97 | 125I-CYP | -7762 | 27 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 425 | 5 | 2 | 5 | 3.4 | Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 | None | |||
| DB01184 | 1462 | 97 | 125I-CYP | -7762 | 27 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 425 | 5 | 2 | 5 | 3.4 | Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 | None | |||
| 2176 | 3127 | 68 | 3H-5HT | -741 | 27 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 4828 | 3127 | 68 | 3H-5HT | -741 | 27 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 91 | 3127 | 68 | 3H-5HT | -741 | 27 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| CHEMBL500 | 3127 | 68 | 3H-5HT | -741 | 27 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| DB00960 | 3127 | 68 | 3H-5HT | -741 | 27 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 2543 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 1209 | 1658 | 75 | 3H-5HT | -1148 | 32 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | |||
| 203 | 1658 | 75 | 3H-5HT | -1148 | 32 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | |||
| 3386 | 1658 | 75 | 3H-5HT | -1148 | 32 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | |||
| CHEMBL41 | 1658 | 75 | 3H-5HT | -1148 | 32 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | |||
| DB00472 | 1658 | 75 | 3H-5HT | -1148 | 32 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | |||
| None | 215971 | 0 | 3H-8-OH-DPAT | -1348 | 15 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 473 | 7 | 0 | 5 | 3.5 | COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br | None | |||
| 135 | 2532 | 43 | 125I-CYP | -851 | 58 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 1796 | 2532 | 43 | 125I-CYP | -851 | 58 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 4184 | 2532 | 43 | 125I-CYP | -851 | 58 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| CHEMBL6437 | 2532 | 43 | 125I-CYP | -851 | 58 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| DB06148 | 2532 | 43 | 125I-CYP | -851 | 58 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 21163 | 215930 | 0 | 125I-CYP | -4 | 5 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 192 | 2 | 4 | 3 | 1.1 | C1=C2C(=CC(=C1O)O)NC=C2CCN | None | |||
| 5475158 | 67213 | 25 | 3H-5HT | -1023 | 14 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 340 | 8 | 1 | 3 | 4.4 | CN(C)CCCSc1ccccc1NC(=O)/C=C/c1ccccc1 | None | |||
| CHEMBL18786 | 67213 | 25 | 3H-5HT | -1023 | 14 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 340 | 8 | 1 | 3 | 4.4 | CN(C)CCCSc1ccccc1NC(=O)/C=C/c1ccccc1 | None | |||
| 2176 | 3127 | 68 | 3H-5HT | -199 | 27 | Mouse | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 4828 | 3127 | 68 | 3H-5HT | -199 | 27 | Mouse | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 91 | 3127 | 68 | 3H-5HT | -199 | 27 | Mouse | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| CHEMBL500 | 3127 | 68 | 3H-5HT | -199 | 27 | Mouse | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| DB00960 | 3127 | 68 | 3H-5HT | -199 | 27 | Mouse | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 1220 | 187 | 55 | 3H-5HT | -208 | 44 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 31 | 187 | 55 | 3H-5HT | -208 | 44 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 7 | 187 | 55 | 3H-5HT | -208 | 44 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| CHEMBL56 | 187 | 55 | 3H-5HT | -208 | 44 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 206 | 2493 | 16 | 3H-5HT | -549 | 25 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | None | |||
| 68848 | 2493 | 16 | 3H-5HT | -549 | 25 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | None | |||
| CHEMBL12314 | 2493 | 16 | 3H-5HT | -549 | 25 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | None | |||
| 2303 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 4946 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 564 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 63 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 91536 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| CHEMBL27 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| CHEMBL452861 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| DB00571 | 3187 | 68 | 3H-5HT | -1174 | 26 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 138107169 | 215952 | 0 | 125I-ICYP | -19054 | 22 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O | None | |||
| 22831402 | 215952 | 0 | 125I-ICYP | -19054 | 22 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O | None | |||
| None | 216214 | 0 | 3H-5HT | -588 | 14 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 438 | 5 | 1 | 4 | 4.8 | C1CC(CCC1CCN2CCC3=C(C2)C=CC(=C3)C#N)NC(=O)C4=CC=NC5=CC=CC=C45 | None | |||
| 88747 | 204478 | 128 | 125I-CYP | -4 | 5 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 164 | 1 | 1 | 4 | -0.1 | c1cnc(N2CCNCC2)nc1 | None | |||
| CHEMBL724 | 204478 | 128 | 125I-CYP | -4 | 5 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 164 | 1 | 1 | 4 | -0.1 | c1cnc(N2CCNCC2)nc1 | None | |||
| 115 | 3791 | 80 | 3H-5HT | -2 | 27 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 4296 | 3791 | 80 | 3H-5HT | -2 | 27 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| CHEMBL274866 | 3791 | 80 | 3H-5HT | -2 | 27 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 71299720 | 215951 | 0 | 3H-GR-125743 | -51 | 17 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 450 | 3 | 2 | 6 | 3.0 | CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4.C(=CC(=O)O)C(=O)O | None | |||
| 127 | 3126 | 52 | 125I-CYP | -95 | 15 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 688095 | 3126 | 52 | 125I-CYP | -95 | 15 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| CHEMBL117405 | 3126 | 52 | 125I-CYP | -95 | 15 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 206 | 2493 | 16 | 3H-5HT | -549 | 25 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | None | |||
| 68848 | 2493 | 16 | 3H-5HT | -549 | 25 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | None | |||
| CHEMBL12314 | 2493 | 16 | 3H-5HT | -549 | 25 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | None | |||
| 165193 | 215945 | 0 | 3H-5HT | -1000 | 30 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 62882 | 215945 | 0 | 3H-5HT | -1000 | 30 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 66366 | 215945 | 0 | 3H-5HT | -1000 | 30 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 21830793 | 91835 | 10 | 3H-8-OH-DPAT | -4265 | 45 | Bovine | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 373 | 7 | 0 | 8 | 0.6 | COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 | None | |||
| CHEMBL2413154 | 91835 | 10 | 3H-8-OH-DPAT | -4265 | 45 | Bovine | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 373 | 7 | 0 | 8 | 0.6 | COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 | None | |||
| 135398737 | 958 | 93 | 3H-Alniditan | -151 | 89 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 38 | 958 | 93 | 3H-Alniditan | -151 | 89 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 722 | 958 | 93 | 3H-Alniditan | -151 | 89 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| CHEMBL42 | 958 | 93 | 3H-Alniditan | -151 | 89 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| DB00363 | 958 | 93 | 3H-Alniditan | -151 | 89 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 71299720 | 215951 | 0 | 3H-GR-125743 | -44 | 17 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 450 | 3 | 2 | 6 | 3.0 | CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4.C(=CC(=O)O)C(=O)O | None | |||
| 135398745 | 2914 | 112 | 3H-Alniditan | -199 | 65 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| 47 | 2914 | 112 | 3H-Alniditan | -199 | 65 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| CHEMBL715 | 2914 | 112 | 3H-Alniditan | -199 | 65 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| DB00334 | 2914 | 112 | 3H-Alniditan | -199 | 65 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| 283 | 3130 | 57 | 3H-5HT | -6606 | 12 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 393 | 5 | 0 | 5 | 3.3 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2 | None | |||
| 4847 | 3130 | 57 | 3H-5HT | -6606 | 12 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 393 | 5 | 0 | 5 | 3.3 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2 | None | |||
| CHEMBL18331 | 3130 | 57 | 3H-5HT | -6606 | 12 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 393 | 5 | 0 | 5 | 3.3 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2 | None | |||
| 103 | 4153 | 61 | 3H-GR-125743 | -48 | 53 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 2875 | 4153 | 61 | 3H-GR-125743 | -48 | 53 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 5736 | 4153 | 61 | 3H-GR-125743 | -48 | 53 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| CHEMBL285802 | 4153 | 61 | 3H-GR-125743 | -48 | 53 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| DB09225 | 4153 | 61 | 3H-GR-125743 | -48 | 53 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 46780481 | 107531 | 20 | 3H-5HT | -363 | 53 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| 9903970 | 107531 | 20 | 3H-5HT | -363 | 53 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| CHEMBL3187365 | 107531 | 20 | 3H-5HT | -363 | 53 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| CHEMBL3544974 | 107531 | 20 | 3H-5HT | -363 | 53 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| None | 215939 | 0 | 3H-5HT | -218 | 6 | Rat | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 370 | 6 | 2 | 7 | 2.1 | CC(C1=CC=CC2=NC3=C(C=CC=C3N=C21)C(=O)O)OC(=O)C(CO)OC | None | |||
| 6917970 | 3691 | 61 | 3H-GR-125743 | -1584 | 34 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 327 | 2 | 2 | 5 | 2.8 | COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O | None | |||
| 8370 | 3691 | 61 | 3H-GR-125743 | -1584 | 34 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 327 | 2 | 2 | 5 | 2.8 | COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O | None | |||
| CHEMBL487387 | 3691 | 61 | 3H-GR-125743 | -1584 | 34 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 327 | 2 | 2 | 5 | 2.8 | COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O | None | |||
| 3294 | 2006 | 111 | None | -57 | 45 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | |||
| 71360 | 2006 | 111 | None | -57 | 45 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | |||
| 87 | 2006 | 111 | None | -57 | 45 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | |||
| CHEMBL14376 | 2006 | 111 | None | -57 | 45 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | |||
| DB04946 | 2006 | 111 | None | -57 | 45 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | |||
| 2176 | 3127 | 68 | None | -741 | 27 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 4828 | 3127 | 68 | None | -741 | 27 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 91 | 3127 | 68 | None | -741 | 27 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| CHEMBL500 | 3127 | 68 | None | -741 | 27 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| DB00960 | 3127 | 68 | None | -741 | 27 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 2176 | 3127 | 68 | None | -1737 | 27 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 4828 | 3127 | 68 | None | -1737 | 27 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 91 | 3127 | 68 | None | -1737 | 27 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| CHEMBL500 | 3127 | 68 | None | -1737 | 27 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| DB00960 | 3127 | 68 | None | -1737 | 27 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 133 | 2496 | 52 | None | -23 | 42 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 1723 | 2496 | 52 | None | -23 | 42 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 28693 | 2496 | 52 | None | -23 | 42 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| CHEMBL19215 | 2496 | 52 | None | -23 | 42 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| DB13520 | 2496 | 52 | None | -23 | 42 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 103 | 4153 | 61 | None | -48 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 2875 | 4153 | 61 | None | -48 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 5736 | 4153 | 61 | None | -48 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| CHEMBL285802 | 4153 | 61 | None | -48 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| DB09225 | 4153 | 61 | None | -48 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 1809 | 134 | 32 | 125I-ICYP | -32 | 36 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 125I-ICYP | -32 | 36 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 125I-ICYP | -32 | 36 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 2435 | 3590 | 83 | None | -128 | 48 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 60149 | 3590 | 83 | None | -128 | 48 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 98 | 3590 | 83 | None | -128 | 48 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| CHEMBL12713 | 3590 | 83 | None | -128 | 48 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| DB06144 | 3590 | 83 | None | -128 | 48 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 2303 | 3187 | 68 | None | -57 | 26 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 4946 | 3187 | 68 | None | -57 | 26 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 564 | 3187 | 68 | None | -57 | 26 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 63 | 3187 | 68 | None | -57 | 26 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 91536 | 3187 | 68 | None | -57 | 26 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| CHEMBL27 | 3187 | 68 | None | -57 | 26 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| CHEMBL452861 | 3187 | 68 | None | -57 | 26 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| DB00571 | 3187 | 68 | None | -57 | 26 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 3652 | 4097 | 79 | None | -3 | 18 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| 57 | 4097 | 79 | None | -3 | 18 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| 60809 | 4097 | 79 | None | -3 | 18 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| CHEMBL21536 | 4097 | 79 | None | -3 | 18 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| DB15357 | 4097 | 79 | None | -3 | 18 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| 31101 | 729 | 40 | None | -48 | 36 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
| 35 | 729 | 40 | None | -48 | 36 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
| 403 | 729 | 40 | None | -48 | 36 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
| CHEMBL493 | 729 | 40 | None | -48 | 36 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
| DB01200 | 729 | 40 | None | -48 | 36 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
| 2105 | 3054 | 37 | None | -27 | 33 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
| 47811 | 3054 | 37 | None | -27 | 33 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
| 48 | 3054 | 37 | None | -27 | 33 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
| CHEMBL531 | 3054 | 37 | None | -27 | 33 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
| DB01186 | 3054 | 37 | None | -27 | 33 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
| 1342 | 35 | 49 | 3H-5HT | -4 | 19 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| 3 | 35 | 49 | 3H-5HT | -4 | 19 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| CHEMBL277120 | 35 | 49 | 3H-5HT | -4 | 19 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| 71299720 | 215951 | 0 | 3H-5HT | -44 | 17 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 450 | 3 | 2 | 6 | 3.0 | CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4.C(=CC(=O)O)C(=O)O | None | |||
| 71299720 | 215951 | 0 | 3H-5HT | -44 | 17 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 450 | 3 | 2 | 6 | 3.0 | CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4.C(=CC(=O)O)C(=O)O | None | |||
| 4806 | 4008 | 88 | None | -2 | 13 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | None | |||
| 7351 | 4008 | 88 | None | -2 | 13 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | None | |||
| 9966051 | 4008 | 88 | None | -2 | 13 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | None | |||
| CHEMBL2104993 | 4008 | 88 | None | -2 | 13 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | None | |||
| DB09068 | 4008 | 88 | None | -2 | 13 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | None | |||
| 2389 | 3331 | 118 | None | -93 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 5073 | 3331 | 118 | None | -93 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 96 | 3331 | 118 | None | -93 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| CHEMBL85 | 3331 | 118 | None | -93 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| DB00734 | 3331 | 118 | None | -93 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 11978813 | 721 | 79 | None | -9 | 24 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 433 | 7 | 1 | 5 | 4.7 | O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 | None | |||
| 5014 | 721 | 79 | None | -9 | 24 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 433 | 7 | 1 | 5 | 4.7 | O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 | None | |||
| 7672 | 721 | 79 | None | -9 | 24 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 433 | 7 | 1 | 5 | 4.7 | O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 | None | |||
| CHEMBL2105760 | 721 | 79 | None | -9 | 24 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 433 | 7 | 1 | 5 | 4.7 | O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 | None | |||
| DB09128 | 721 | 79 | None | -9 | 24 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 433 | 7 | 1 | 5 | 4.7 | O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 | None | |||
| 135 | 2532 | 43 | None | -3 | 58 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 1796 | 2532 | 43 | None | -3 | 58 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 4184 | 2532 | 43 | None | -3 | 58 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| CHEMBL6437 | 2532 | 43 | None | -3 | 58 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| DB06148 | 2532 | 43 | None | -3 | 58 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 134 | 2514 | 24 | 3H-5HT | -14 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1775 | 2514 | 24 | 3H-5HT | -14 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 9681 | 2514 | 24 | 3H-5HT | -14 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| CHEMBL1065 | 2514 | 24 | 3H-5HT | -14 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| DB00247 | 2514 | 24 | 3H-5HT | -14 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 133 | 2496 | 52 | None | -40 | 42 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 1723 | 2496 | 52 | None | -40 | 42 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 28693 | 2496 | 52 | None | -40 | 42 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| CHEMBL19215 | 2496 | 52 | None | -40 | 42 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| DB13520 | 2496 | 52 | None | -40 | 42 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 134 | 2514 | 24 | None | -14 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1775 | 2514 | 24 | None | -14 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 9681 | 2514 | 24 | None | -14 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| CHEMBL1065 | 2514 | 24 | None | -14 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| DB00247 | 2514 | 24 | None | -14 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 102 | 4127 | 48 | None | -64 | 49 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 3659 | 4127 | 48 | None | -64 | 49 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 8969 | 4127 | 48 | None | -64 | 49 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| CHEMBL15245 | 4127 | 48 | None | -64 | 49 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| DB01392 | 4127 | 48 | None | -64 | 49 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 5 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-5HT | -13 | 54 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 2543 | 3707 | 68 | None | -17 | 32 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | None | -17 | 32 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | None | -17 | 32 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | None | -17 | 32 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | None | -17 | 32 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 115237 | 55585 | 119 | None | -93 | 54 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | |||
| CHEMBL1621 | 55585 | 119 | None | -93 | 54 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | |||
| 1588 | 2325 | 27 | None | -42 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 28864 | 2325 | 27 | None | -42 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 43 | 2325 | 27 | None | -42 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| CHEMBL157138 | 2325 | 27 | None | -42 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| DB00589 | 2325 | 27 | None | -42 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 2869 | 4152 | 89 | None | -8 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | None | |||
| 60 | 4152 | 89 | None | -8 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | None | |||
| 60857 | 4152 | 89 | None | -8 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | None | |||
| CHEMBL1185 | 4152 | 89 | None | -8 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | None | |||
| DB00315 | 4152 | 89 | None | -8 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | None | |||
| 2543 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 2477 | 745 | 59 | None | -16 | 29 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| 36 | 745 | 59 | None | -16 | 29 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| 437 | 745 | 59 | None | -16 | 29 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| CHEMBL49 | 745 | 59 | None | -16 | 29 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| DB00490 | 745 | 59 | None | -16 | 29 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| 3658 | 4107 | 53 | None | -4 | 8 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 244 | 2 | 1 | 2 | 3.1 | Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C | None | |||
| 517 | 4107 | 53 | None | -4 | 8 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 244 | 2 | 1 | 2 | 3.1 | Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C | None | |||
| 5709 | 4107 | 53 | None | -4 | 8 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 244 | 2 | 1 | 2 | 3.1 | Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C | None | |||
| CHEMBL312448 | 4107 | 53 | None | -4 | 8 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 244 | 2 | 1 | 2 | 3.1 | Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C | None | |||
| DB06694 | 4107 | 53 | None | -4 | 8 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 244 | 2 | 1 | 2 | 3.1 | Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C | None | |||
| 5 | 139 | 72 | 35S-GTPGammaS | -11 | 54 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 35S-GTPGammaS | -11 | 54 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 35S-GTPGammaS | -11 | 54 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 35S-GTPGammaS | -11 | 54 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 107780 | 1844 | 54 | 35S-GTPGammaS | 1 | 17 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 14 | 1844 | 54 | 35S-GTPGammaS | 1 | 17 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| CHEMBL15928 | 1844 | 54 | 35S-GTPGammaS | 1 | 17 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 28 | 3496 | 46 | 35S-GTPGammaS | 13 | 10 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 3292447 | 3496 | 46 | 35S-GTPGammaS | 13 | 10 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| CHEMBL20963 | 3496 | 46 | 35S-GTPGammaS | 13 | 10 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 107715 | 200945 | 22 | None | -22 | 19 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 611 | 5 | 3 | 6 | 2.7 | CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O | None | |||
| CHEMBL1255837 | 200945 | 22 | None | -22 | 19 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 611 | 5 | 3 | 6 | 2.7 | CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O | None | |||
| CHEMBL601773 | 200945 | 22 | None | -22 | 19 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 611 | 5 | 3 | 6 | 2.7 | CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O | None | |||
| 1251 | 1692 | 30 | None | -1 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 243 | 2 | 4 | 2 | 2.1 | CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O | None | |||
| 7191 | 1692 | 30 | None | -1 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 243 | 2 | 4 | 2 | 2.1 | CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O | None | |||
| 77992 | 1692 | 30 | None | -1 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 243 | 2 | 4 | 2 | 2.1 | CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O | None | |||
| CHEMBL1279 | 1692 | 30 | None | -1 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 243 | 2 | 4 | 2 | 2.1 | CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O | None | |||
| DB00998 | 1692 | 30 | None | -1 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 243 | 2 | 4 | 2 | 2.1 | CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O | None | |||
| 186 | 1807 | 52 | 3H-GR-125743 | -11 | 17 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 295 | 5 | 1 | 2 | 3.7 | OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1 | None | |||
| 71781 | 1807 | 52 | 3H-GR-125743 | -11 | 17 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 295 | 5 | 1 | 2 | 3.7 | OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1 | None | |||
| CHEMBL18972 | 1807 | 52 | 3H-GR-125743 | -11 | 17 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 295 | 5 | 1 | 2 | 3.7 | OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1 | None | |||
| 137 | 370 | 52 | 125I-ICYP | -154 | 12 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 249 | 8 | 2 | 3 | 2.2 | C=CCc1ccccc1OCC(CNC(C)C)O | None | |||
| 2119 | 370 | 52 | 125I-ICYP | -154 | 12 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 249 | 8 | 2 | 3 | 2.2 | C=CCc1ccccc1OCC(CNC(C)C)O | None | |||
| 563 | 370 | 52 | 125I-ICYP | -154 | 12 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 249 | 8 | 2 | 3 | 2.2 | C=CCc1ccccc1OCC(CNC(C)C)O | None | |||
| 66368 | 370 | 52 | 125I-ICYP | -154 | 12 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 249 | 8 | 2 | 3 | 2.2 | C=CCc1ccccc1OCC(CNC(C)C)O | None | |||
| CHEMBL266195 | 370 | 52 | 125I-ICYP | -154 | 12 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 249 | 8 | 2 | 3 | 2.2 | C=CCc1ccccc1OCC(CNC(C)C)O | None | |||
| DB00866 | 370 | 52 | 125I-ICYP | -154 | 12 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 249 | 8 | 2 | 3 | 2.2 | C=CCc1ccccc1OCC(CNC(C)C)O | None | |||
| 1220 | 187 | 55 | 3H-GR-125743 | -208 | 44 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 31 | 187 | 55 | 3H-GR-125743 | -208 | 44 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 7 | 187 | 55 | 3H-GR-125743 | -208 | 44 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| CHEMBL56 | 187 | 55 | 3H-GR-125743 | -208 | 44 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 21138 | 98451 | 39 | 125I-ICYP | -162 | 7 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NC[C@@H](O)COc1cccc2ccccc12 | None | |||
| CHEMBL275742 | 98451 | 39 | 125I-ICYP | -162 | 7 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NC[C@@H](O)COc1cccc2ccccc12 | None | |||
| 1220 | 187 | 55 | 3H-GR-125743 | -208 | 44 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 31 | 187 | 55 | 3H-GR-125743 | -208 | 44 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 7 | 187 | 55 | 3H-GR-125743 | -208 | 44 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| CHEMBL56 | 187 | 55 | 3H-GR-125743 | -208 | 44 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 2389 | 3331 | 118 | 3H-5CT | -93 | 67 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 5073 | 3331 | 118 | 3H-5CT | -93 | 67 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 96 | 3331 | 118 | 3H-5CT | -93 | 67 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| CHEMBL85 | 3331 | 118 | 3H-5CT | -93 | 67 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| DB00734 | 3331 | 118 | 3H-5CT | -93 | 67 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| None | 216239 | 0 | 3H-GR-125743 | -4677 | 30 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 316 | 7 | 3 | 3 | 3.0 | CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O | None | |||
| 1220 | 187 | 55 | 3H-5HT | -7413 | 44 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 31 | 187 | 55 | 3H-5HT | -7413 | 44 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 7 | 187 | 55 | 3H-5HT | -7413 | 44 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| CHEMBL56 | 187 | 55 | 3H-5HT | -7413 | 44 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 145 | 140 | 49 | 3H-5-CT | -8 | 30 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 1832 | 140 | 49 | 3H-5-CT | -8 | 30 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL7257 | 140 | 49 | 3H-5-CT | -8 | 30 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB14010 | 140 | 49 | 3H-5-CT | -8 | 30 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 165193 | 215945 | 0 | 125I-ICYP | -154 | 30 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 62882 | 215945 | 0 | 125I-ICYP | -154 | 30 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 66366 | 215945 | 0 | 125I-ICYP | -154 | 30 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 102 | 4127 | 48 | 125I-ICYP | -2691 | 49 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 3659 | 4127 | 48 | 125I-ICYP | -2691 | 49 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 8969 | 4127 | 48 | 125I-ICYP | -2691 | 49 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| CHEMBL15245 | 4127 | 48 | 125I-ICYP | -2691 | 49 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| DB01392 | 4127 | 48 | 125I-ICYP | -2691 | 49 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 127 | 3126 | 52 | 3H-5HT | -95 | 15 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 688095 | 3126 | 52 | 3H-5HT | -95 | 15 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| CHEMBL117405 | 3126 | 52 | 3H-5HT | -95 | 15 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 2303 | 3187 | 68 | 125I-ICYP | -57 | 26 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 4946 | 3187 | 68 | 125I-ICYP | -57 | 26 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 564 | 3187 | 68 | 125I-ICYP | -57 | 26 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 63 | 3187 | 68 | 125I-ICYP | -57 | 26 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 91536 | 3187 | 68 | 125I-ICYP | -57 | 26 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| CHEMBL27 | 3187 | 68 | 125I-ICYP | -57 | 26 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| CHEMBL452861 | 3187 | 68 | 125I-ICYP | -57 | 26 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| DB00571 | 3187 | 68 | 125I-ICYP | -57 | 26 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | None | |||
| 24882193 | 188649 | 0 | UNDEFINED | -263 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 770 | 14 | 4 | 4 | 10.4 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | None | |||
| CHEMBL503468 | 188649 | 0 | UNDEFINED | -263 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 770 | 14 | 4 | 4 | 10.4 | O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1 | None | |||
| 4209 | 3163 | 75 | 125I-CYP | -9549 | 33 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | None | |||
| 4893 | 3163 | 75 | 125I-CYP | -9549 | 33 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | None | |||
| 503 | 3163 | 75 | 125I-CYP | -9549 | 33 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | None | |||
| 5385 | 3163 | 75 | 125I-CYP | -9549 | 33 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | None | |||
| CHEMBL2 | 3163 | 75 | 125I-CYP | -9549 | 33 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | None | |||
| DB00457 | 3163 | 75 | 125I-CYP | -9549 | 33 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | None | |||
| 123606 | 352 | 70 | None | -1 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 335 | 6 | 1 | 3 | 2.2 | CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C | None | |||
| 128 | 352 | 70 | None | -1 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 335 | 6 | 1 | 3 | 2.2 | CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C | None | |||
| 7110 | 352 | 70 | None | -1 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 335 | 6 | 1 | 3 | 2.2 | CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C | None | |||
| CHEMBL1505 | 352 | 70 | None | -1 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 335 | 6 | 1 | 3 | 2.2 | CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C | None | |||
| DB00918 | 352 | 70 | None | -1 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 335 | 6 | 1 | 3 | 2.2 | CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C | None | |||
| 150 | 2509 | 21 | None | -6 | 16 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | None | |||
| 1764 | 2509 | 21 | None | -6 | 16 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | None | |||
| 8226 | 2509 | 21 | None | -6 | 16 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | None | |||
| CHEMBL1201356 | 2509 | 21 | None | -6 | 16 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | None | |||
| DB00353 | 2509 | 21 | None | -6 | 16 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | None | |||
| 2543 | 3707 | 68 | None | -2 | 32 | Western lowland gorilla | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | None | -2 | 32 | Western lowland gorilla | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | None | -2 | 32 | Western lowland gorilla | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | None | -2 | 32 | Western lowland gorilla | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | None | -2 | 32 | Western lowland gorilla | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 2543 | 3707 | 68 | None | -3 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | None | -3 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | None | -3 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | None | -3 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | None | -3 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 134551 | 358 | 27 | None | -5 | 21 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 575 | 5 | 3 | 6 | 2.4 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C | None | |||
| 271 | 358 | 27 | None | -5 | 21 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 575 | 5 | 3 | 6 | 2.4 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C | None | |||
| 885 | 358 | 27 | None | -5 | 21 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 575 | 5 | 3 | 6 | 2.4 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C | None | |||
| CHEMBL1403281 | 358 | 27 | None | -5 | 21 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 575 | 5 | 3 | 6 | 2.4 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C | None | |||
| 1524 | 2181 | 96 | None | -4 | 52 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 197 | 2181 | 96 | None | -4 | 52 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 3822 | 2181 | 96 | None | -4 | 52 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 88 | 2181 | 96 | None | -4 | 52 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| CHEMBL51 | 2181 | 96 | None | -4 | 52 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| DB12465 | 2181 | 96 | None | -4 | 52 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 135 | 2532 | 43 | None | -3 | 58 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 1796 | 2532 | 43 | None | -3 | 58 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 4184 | 2532 | 43 | None | -3 | 58 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| CHEMBL6437 | 2532 | 43 | None | -3 | 58 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| DB06148 | 2532 | 43 | None | -3 | 58 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 2470 | 3653 | 50 | None | -194 | 59 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 3300 | 3653 | 50 | None | -194 | 59 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 5265 | 3653 | 50 | None | -194 | 59 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 99 | 3653 | 50 | None | -194 | 59 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| CHEMBL267930 | 3653 | 50 | None | -194 | 59 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 102 | 4127 | 48 | None | -186 | 49 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 3659 | 4127 | 48 | None | -186 | 49 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 8969 | 4127 | 48 | None | -186 | 49 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| CHEMBL15245 | 4127 | 48 | None | -186 | 49 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| DB01392 | 4127 | 48 | None | -186 | 49 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 2865 | 4143 | 73 | None | -12 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| 59 | 4143 | 73 | None | -12 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| 60854 | 4143 | 73 | None | -12 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| CHEMBL708 | 4143 | 73 | None | -12 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| DB00246 | 4143 | 73 | None | -12 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| 1588 | 2325 | 27 | None | -58 | 44 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 28864 | 2325 | 27 | None | -58 | 44 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 43 | 2325 | 27 | None | -58 | 44 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| CHEMBL157138 | 2325 | 27 | None | -58 | 44 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| DB00589 | 2325 | 27 | None | -58 | 44 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 46780481 | 107531 | 20 | None | -32 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| 9903970 | 107531 | 20 | None | -32 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| CHEMBL3187365 | 107531 | 20 | None | -32 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| CHEMBL3544974 | 107531 | 20 | None | -32 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| 1884 | 2735 | 58 | None | -3 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | None | |||
| 4440 | 2735 | 58 | None | -3 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | None | |||
| 45 | 2735 | 58 | None | -3 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | None | |||
| CHEMBL1278 | 2735 | 58 | None | -3 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | None | |||
| DB00952 | 2735 | 58 | None | -3 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | None | |||
| 11954224 | 215953 | 0 | None | -32 | 58 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
| 1042 | 1581 | 23 | None | -5 | 17 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | None | |||
| 148 | 1581 | 23 | None | -5 | 17 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | None | |||
| 443884 | 1581 | 23 | None | -5 | 17 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | None | |||
| CHEMBL119443 | 1581 | 23 | None | -5 | 17 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | None | |||
| DB01253 | 1581 | 23 | None | -5 | 17 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | None | |||
| 151 | 2416 | 44 | UNDEFINED | -89 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | None | |||
| 20 | 2416 | 44 | UNDEFINED | -89 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | None | |||
| 5311258 | 2416 | 44 | UNDEFINED | -89 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | None | |||
| CHEMBL101690 | 2416 | 44 | UNDEFINED | -89 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | None | |||
| 242 | 470 | 124 | 3H-GR-125743 | -380 | 51 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| 34 | 470 | 124 | 3H-GR-125743 | -380 | 51 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| 60795 | 470 | 124 | 3H-GR-125743 | -380 | 51 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| CHEMBL1112 | 470 | 124 | 3H-GR-125743 | -380 | 51 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| DB01238 | 470 | 124 | 3H-GR-125743 | -380 | 51 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| 155 | 728 | 25 | 3H-5HT | -263 | 13 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 273 | 4 | 1 | 3 | 2.4 | COc1cc(Br)c(cc1CC(N)C)OC | None | |||
| 163 | 728 | 25 | 3H-5HT | -263 | 13 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 273 | 4 | 1 | 3 | 2.4 | COc1cc(Br)c(cc1CC(N)C)OC | None | |||
| 62065 | 728 | 25 | 3H-5HT | -263 | 13 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 273 | 4 | 1 | 3 | 2.4 | COc1cc(Br)c(cc1CC(N)C)OC | None | |||
| CHEMBL6607 | 728 | 25 | 3H-5HT | -263 | 13 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 273 | 4 | 1 | 3 | 2.4 | COc1cc(Br)c(cc1CC(N)C)OC | None | |||
| DB01484 | 728 | 25 | 3H-5HT | -263 | 13 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 273 | 4 | 1 | 3 | 2.4 | COc1cc(Br)c(cc1CC(N)C)OC | None | |||
| 104911 | 216019 | 0 | 3H-8-OH-DPAT | -38018 | 37 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 530 | 7 | 0 | 5 | 5.1 | COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl | None | |||
| 119570 | 3159 | 96 | 3H-GR-125743 | -660 | 40 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | |||
| 2233 | 3159 | 96 | 3H-GR-125743 | -660 | 40 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | |||
| 953 | 3159 | 96 | 3H-GR-125743 | -660 | 40 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | |||
| CHEMBL301265 | 3159 | 96 | 3H-GR-125743 | -660 | 40 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | |||
| DB00413 | 3159 | 96 | 3H-GR-125743 | -660 | 40 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | |||
| 242 | 470 | 124 | 3H-GR-125743 | -380 | 51 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| 34 | 470 | 124 | 3H-GR-125743 | -380 | 51 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| 60795 | 470 | 124 | 3H-GR-125743 | -380 | 51 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| CHEMBL1112 | 470 | 124 | 3H-GR-125743 | -380 | 51 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| DB01238 | 470 | 124 | 3H-GR-125743 | -380 | 51 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| 115 | 3791 | 80 | 125I-ICYP | 1 | 27 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 4296 | 3791 | 80 | 125I-ICYP | 1 | 27 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| CHEMBL274866 | 3791 | 80 | 125I-ICYP | 1 | 27 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 180 | 401 | 56 | 3H-5HT | -389 | 40 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | |||
| 200 | 401 | 56 | 3H-5HT | -389 | 40 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | |||
| 2160 | 401 | 56 | 3H-5HT | -389 | 40 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | |||
| CHEMBL629 | 401 | 56 | 3H-5HT | -389 | 40 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | |||
| DB00321 | 401 | 56 | 3H-5HT | -389 | 40 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | |||
| 277 | 1301 | 62 | 3H-5HT | -501 | 50 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | |||
| 2913 | 1301 | 62 | 3H-5HT | -501 | 50 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | |||
| 765 | 1301 | 62 | 3H-5HT | -501 | 50 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | |||
| CHEMBL516 | 1301 | 62 | 3H-5HT | -501 | 50 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | |||
| DB00434 | 1301 | 62 | 3H-5HT | -501 | 50 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | |||
| 62787 | 206188 | 21 | 3H-5HT | -85 | 10 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 195 | 4 | 1 | 3 | 1.6 | COc1ccc(OC)c(CC(C)N)c1 | None | |||
| CHEMBL8642 | 206188 | 21 | 3H-5HT | -85 | 10 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 195 | 4 | 1 | 3 | 1.6 | COc1ccc(OC)c(CC(C)N)c1 | None | |||
| 165193 | 215945 | 0 | 3H-5-CT | -1000 | 30 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 62882 | 215945 | 0 | 3H-5-CT | -1000 | 30 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 66366 | 215945 | 0 | 3H-5-CT | -1000 | 30 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 165193 | 215945 | 0 | 125I-CYP | -154 | 30 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 62882 | 215945 | 0 | 125I-CYP | -154 | 30 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 66366 | 215945 | 0 | 125I-CYP | -154 | 30 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O | None | |||
| 1574 | 81 | 60 | 3H-5HT | -8 | 21 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | None | |||
| 218 | 81 | 60 | 3H-5HT | -8 | 21 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | None | |||
| CHEMBL266591 | 81 | 60 | 3H-5HT | -8 | 21 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | None | |||
| 1150 | 3878 | 121 | 3H-5HT | -7 | 25 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | |||
| 125 | 3878 | 121 | 3H-5HT | -7 | 25 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | |||
| CHEMBL6640 | 3878 | 121 | 3H-5HT | -7 | 25 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | |||
| DB08653 | 3878 | 121 | 3H-5HT | -7 | 25 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | |||
| 2142 | 3096 | 58 | 125I-ICYP | -741 | 36 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | |||
| 4920903 | 3096 | 58 | 125I-ICYP | -741 | 36 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | |||
| 502 | 3096 | 58 | 125I-ICYP | -741 | 36 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | |||
| 5775 | 3096 | 58 | 125I-ICYP | -741 | 36 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | |||
| CHEMBL597 | 3096 | 58 | 125I-ICYP | -741 | 36 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | |||
| DB00692 | 3096 | 58 | 125I-ICYP | -741 | 36 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | |||
| 138107169 | 215952 | 0 | 125I-ICYP | -19054 | 22 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O | None | |||
| 22831402 | 215952 | 0 | 125I-ICYP | -19054 | 22 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O | None | |||
| 1353 | 1911 | 93 | 125I-CYP | -5248 | 83 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 3559 | 1911 | 93 | 125I-CYP | -5248 | 83 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 86 | 1911 | 93 | 125I-CYP | -5248 | 83 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| CHEMBL54 | 1911 | 93 | 125I-CYP | -5248 | 83 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| DB00502 | 1911 | 93 | 125I-CYP | -5248 | 83 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 3294 | 2006 | 111 | 3H-5HT | -57 | 45 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | |||
| 71360 | 2006 | 111 | 3H-5HT | -57 | 45 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | |||
| 87 | 2006 | 111 | 3H-5HT | -57 | 45 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | |||
| CHEMBL14376 | 2006 | 111 | 3H-5HT | -57 | 45 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | |||
| DB04946 | 2006 | 111 | 3H-5HT | -57 | 45 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | |||
| 7153 | 98020 | 77 | 3H-5HT | -11 | 34 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | |||
| CHEMBL272942 | 98020 | 77 | 3H-5HT | -11 | 34 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | |||
| 5 | 139 | 72 | 3H-GR-125743 | -11 | 54 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5 | 139 | 72 | 125I-ICYP | -13 | 54 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-GR-125743 | -11 | 54 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 125I-ICYP | -13 | 54 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-GR-125743 | -11 | 54 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 125I-ICYP | -13 | 54 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-GR-125743 | -11 | 54 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 125I-ICYP | -13 | 54 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 124 | 2981 | 47 | None | -2 | 33 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| 2032 | 2981 | 47 | None | -2 | 33 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| 4636 | 2981 | 47 | None | -2 | 33 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| CHEMBL762 | 2981 | 47 | None | -2 | 33 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| DB00935 | 2981 | 47 | None | -2 | 33 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| 2543 | 3707 | 68 | UNDEFINED | -3 | 32 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | UNDEFINED | -3 | 32 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | UNDEFINED | -3 | 32 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | UNDEFINED | -3 | 32 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | UNDEFINED | -3 | 32 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 10531 | 1420 | 21 | None | -12 | 23 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | None | |||
| 121 | 1420 | 21 | None | -12 | 23 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | None | |||
| 888 | 1420 | 21 | None | -12 | 23 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | None | |||
| CHEMBL1732 | 1420 | 21 | None | -12 | 23 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | None | |||
| DB00320 | 1420 | 21 | None | -12 | 23 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | None | |||
| 2543 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | 3H-5HT | -3 | 32 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 133 | 2496 | 52 | 3H-GR-125743 | -23 | 42 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 1723 | 2496 | 52 | 3H-GR-125743 | -23 | 42 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 28693 | 2496 | 52 | 3H-GR-125743 | -23 | 42 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| CHEMBL19215 | 2496 | 52 | 3H-GR-125743 | -23 | 42 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| DB13520 | 2496 | 52 | 3H-GR-125743 | -23 | 42 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 1884 | 2735 | 58 | 3H-GR-125743 | -3 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | None | |||
| 4440 | 2735 | 58 | 3H-GR-125743 | -3 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | None | |||
| 45 | 2735 | 58 | 3H-GR-125743 | -3 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | None | |||
| CHEMBL1278 | 2735 | 58 | 3H-GR-125743 | -3 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | None | |||
| DB00952 | 2735 | 58 | 3H-GR-125743 | -3 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | None | |||
| 10531 | 1420 | 21 | None | -5 | 23 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | None | |||
| 121 | 1420 | 21 | None | -5 | 23 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | None | |||
| 888 | 1420 | 21 | None | -5 | 23 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | None | |||
| CHEMBL1732 | 1420 | 21 | None | -5 | 23 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | None | |||
| DB00320 | 1420 | 21 | None | -5 | 23 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | None | |||
| 124 | 2981 | 47 | None | 1 | 33 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| 2032 | 2981 | 47 | None | 1 | 33 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| 4636 | 2981 | 47 | None | 1 | 33 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| CHEMBL762 | 2981 | 47 | None | 1 | 33 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| DB00935 | 2981 | 47 | None | 1 | 33 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| 2389 | 3331 | 118 | 3H-Alniditan | -93 | 67 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 5073 | 3331 | 118 | 3H-Alniditan | -93 | 67 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 96 | 3331 | 118 | 3H-Alniditan | -93 | 67 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| CHEMBL85 | 3331 | 118 | 3H-Alniditan | -93 | 67 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| DB00734 | 3331 | 118 | 3H-Alniditan | -93 | 67 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 7153 | 98020 | 77 | 3H-5HT | -11 | 34 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | |||
| CHEMBL272942 | 98020 | 77 | 3H-5HT | -11 | 34 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | |||
| 10257 | 738 | 31 | 125I-CYP | -141 | 19 | Rat | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 204 | 3 | 2 | 2 | 2.0 | CN(CCc1c[nH]c2c1cc(O)cc2)C | None | |||
| 10257 | 738 | 31 | 3H-5HT | -141 | 19 | Rat | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 204 | 3 | 2 | 2 | 2.0 | CN(CCc1c[nH]c2c1cc(O)cc2)C | None | |||
| 144 | 738 | 31 | 125I-CYP | -141 | 19 | Rat | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 204 | 3 | 2 | 2 | 2.0 | CN(CCc1c[nH]c2c1cc(O)cc2)C | None | |||
| 144 | 738 | 31 | 3H-5HT | -141 | 19 | Rat | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 204 | 3 | 2 | 2 | 2.0 | CN(CCc1c[nH]c2c1cc(O)cc2)C | None | |||
| CHEMBL416526 | 738 | 31 | 125I-CYP | -141 | 19 | Rat | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 204 | 3 | 2 | 2 | 2.0 | CN(CCc1c[nH]c2c1cc(O)cc2)C | None | |||
| CHEMBL416526 | 738 | 31 | 3H-5HT | -141 | 19 | Rat | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 204 | 3 | 2 | 2 | 2.0 | CN(CCc1c[nH]c2c1cc(O)cc2)C | None | |||
| DB01445 | 738 | 31 | 125I-CYP | -141 | 19 | Rat | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 204 | 3 | 2 | 2 | 2.0 | CN(CCc1c[nH]c2c1cc(O)cc2)C | None | |||
| DB01445 | 738 | 31 | 3H-5HT | -141 | 19 | Rat | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 204 | 3 | 2 | 2 | 2.0 | CN(CCc1c[nH]c2c1cc(O)cc2)C | None | |||
| None | 216135 | 0 | 3H-GR-125743 | -3162 | 24 | Rat | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 772 | 16 | 4 | 10 | 5.5 | CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.C(=CC(=O)O)C(=O)O | None | |||
| 1574 | 81 | 60 | 3H-5HT | -8 | 21 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | None | |||
| 218 | 81 | 60 | 3H-5HT | -8 | 21 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | None | |||
| CHEMBL266591 | 81 | 60 | 3H-5HT | -8 | 21 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | None | |||
| 2176 | 3127 | 68 | 125I-CYP | -741 | 27 | Rat | 5.0 | pKi | = | 5.0 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 4828 | 3127 | 68 | 125I-CYP | -741 | 27 | Rat | 5.0 | pKi | = | 5.0 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 91 | 3127 | 68 | 125I-CYP | -741 | 27 | Rat | 5.0 | pKi | = | 5.0 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| CHEMBL500 | 3127 | 68 | 125I-CYP | -741 | 27 | Rat | 5.0 | pKi | = | 5.0 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| DB00960 | 3127 | 68 | 125I-CYP | -741 | 27 | Rat | 5.0 | pKi | = | 5.0 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 107992 | 2553 | 49 | 125I-CYP | -12 | 10 | Rat | 5.0 | pKi | = | 5.0 | Binding | PDSP KiDatabase | 198 | 1 | 1 | 4 | 0.5 | Clc1cncc(n1)N1CCNCC1 | None | |||
| 165 | 2553 | 49 | 125I-CYP | -12 | 10 | Rat | 5.0 | pKi | = | 5.0 | Binding | PDSP KiDatabase | 198 | 1 | 1 | 4 | 0.5 | Clc1cncc(n1)N1CCNCC1 | None | |||
| CHEMBL269521 | 2553 | 49 | 125I-CYP | -12 | 10 | Rat | 5.0 | pKi | = | 5.0 | Binding | PDSP KiDatabase | 198 | 1 | 1 | 4 | 0.5 | Clc1cncc(n1)N1CCNCC1 | None | |||
| DB12111 | 2553 | 49 | 125I-CYP | -12 | 10 | Rat | 5.0 | pKi | = | 5.0 | Binding | PDSP KiDatabase | 198 | 1 | 1 | 4 | 0.5 | Clc1cncc(n1)N1CCNCC1 | None | |||
| 3012003 | 216145 | 0 | 3H-5HT | -371 | 12 | Rat | 5.0 | pKi | = | 5.0 | Binding | PDSP KiDatabase | 311 | 5 | 0 | 3 | 3.8 | CN1CCC(C(C1)COC2=CC=C(C=C2)OC)C3=CC=CC=C3 | None | |||
| 107992 | 2553 | 49 | 125I-CYP | -12 | 10 | Rat | 5.0 | pKi | = | 5.0 | Binding | PDSP KiDatabase | 198 | 1 | 1 | 4 | 0.5 | Clc1cncc(n1)N1CCNCC1 | None | |||
| 165 | 2553 | 49 | 125I-CYP | -12 | 10 | Rat | 5.0 | pKi | = | 5.0 | Binding | PDSP KiDatabase | 198 | 1 | 1 | 4 | 0.5 | Clc1cncc(n1)N1CCNCC1 | None | |||
| CHEMBL269521 | 2553 | 49 | 125I-CYP | -12 | 10 | Rat | 5.0 | pKi | = | 5.0 | Binding | PDSP KiDatabase | 198 | 1 | 1 | 4 | 0.5 | Clc1cncc(n1)N1CCNCC1 | None | |||
| DB12111 | 2553 | 49 | 125I-CYP | -12 | 10 | Rat | 5.0 | pKi | = | 5.0 | Binding | PDSP KiDatabase | 198 | 1 | 1 | 4 | 0.5 | Clc1cncc(n1)N1CCNCC1 | None | |||
| 103 | 4153 | 61 | 3H-5HT | -776 | 53 | Rat | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 2875 | 4153 | 61 | 3H-5HT | -776 | 53 | Rat | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 5736 | 4153 | 61 | 3H-5HT | -776 | 53 | Rat | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| CHEMBL285802 | 4153 | 61 | 3H-5HT | -776 | 53 | Rat | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| DB09225 | 4153 | 61 | 3H-5HT | -776 | 53 | Rat | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 4106 | 2502 | 22 | 125I-ICYP | -102 | 34 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 5358812 | 2502 | 22 | 125I-ICYP | -102 | 34 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 89 | 2502 | 22 | 125I-ICYP | -102 | 34 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| CHEMBL93240 | 2502 | 22 | 125I-ICYP | -102 | 34 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 7153 | 98020 | 77 | 125I-ICYP | -10 | 34 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | |||
| CHEMBL272942 | 98020 | 77 | 125I-ICYP | -10 | 34 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | |||
| 3294 | 2006 | 111 | 3H-5CT | -57 | 45 | Human | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | |||
| 71360 | 2006 | 111 | 3H-5CT | -57 | 45 | Human | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | |||
| 87 | 2006 | 111 | 3H-5CT | -57 | 45 | Human | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | |||
| CHEMBL14376 | 2006 | 111 | 3H-5CT | -57 | 45 | Human | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | |||
| DB04946 | 2006 | 111 | 3H-5CT | -57 | 45 | Human | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | |||
| 2470 | 3653 | 50 | 3H-5HT | -95499 | 59 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 3300 | 3653 | 50 | 3H-5HT | -95499 | 59 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 5265 | 3653 | 50 | 3H-5HT | -95499 | 59 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 99 | 3653 | 50 | 3H-5HT | -95499 | 59 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| CHEMBL267930 | 3653 | 50 | 3H-5HT | -95499 | 59 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 2393 | 3334 | 82 | None | -1 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10193663 | |||
| 5078 | 3334 | 82 | None | -1 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10193663 | |||
| 51 | 3334 | 82 | None | -1 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10193663 | |||
| CHEMBL905 | 3334 | 82 | None | -1 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10193663 | |||
| DB00953 | 3334 | 82 | None | -1 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10193663 | |||
| 2389 | 3331 | 118 | None | -93 | 67 | Human | 7.0 | pKi | = | 7.0 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 18308814 | |||
| 2389 | 3331 | 118 | None | -93 | 67 | Human | 7.0 | pKi | = | 7.0 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 8935801 | |||
| 2389 | 3331 | 118 | None | -93 | 67 | Human | 7.0 | pKi | = | 7.0 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 9605573 | |||
| 5073 | 3331 | 118 | None | -93 | 67 | Human | 7.0 | pKi | = | 7.0 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 18308814 | |||
| 5073 | 3331 | 118 | None | -93 | 67 | Human | 7.0 | pKi | = | 7.0 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 8935801 | |||
| 5073 | 3331 | 118 | None | -93 | 67 | Human | 7.0 | pKi | = | 7.0 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 9605573 | |||
| 96 | 3331 | 118 | None | -93 | 67 | Human | 7.0 | pKi | = | 7.0 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 18308814 | |||
| 96 | 3331 | 118 | None | -93 | 67 | Human | 7.0 | pKi | = | 7.0 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 8935801 | |||
| 96 | 3331 | 118 | None | -93 | 67 | Human | 7.0 | pKi | = | 7.0 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 9605573 | |||
| CHEMBL85 | 3331 | 118 | None | -93 | 67 | Human | 7.0 | pKi | = | 7.0 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 18308814 | |||
| CHEMBL85 | 3331 | 118 | None | -93 | 67 | Human | 7.0 | pKi | = | 7.0 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 8935801 | |||
| CHEMBL85 | 3331 | 118 | None | -93 | 67 | Human | 7.0 | pKi | = | 7.0 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 9605573 | |||
| DB00734 | 3331 | 118 | None | -93 | 67 | Human | 7.0 | pKi | = | 7.0 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 18308814 | |||
| DB00734 | 3331 | 118 | None | -93 | 67 | Human | 7.0 | pKi | = | 7.0 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 8935801 | |||
| DB00734 | 3331 | 118 | None | -93 | 67 | Human | 7.0 | pKi | = | 7.0 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 9605573 | |||
| 2543 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10193663 | |||
| 2543 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10513577 | |||
| 2543 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10611634 | |||
| 2543 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 11040052 | |||
| 2543 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 1565658 | |||
| 2543 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8863519 | |||
| 2543 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8967979 | |||
| 5358 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10193663 | |||
| 5358 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10513577 | |||
| 5358 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10611634 | |||
| 5358 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 11040052 | |||
| 5358 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 1565658 | |||
| 5358 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8863519 | |||
| 5358 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8967979 | |||
| 54 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10193663 | |||
| 54 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10513577 | |||
| 54 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10611634 | |||
| 54 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 11040052 | |||
| 54 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 1565658 | |||
| 54 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8863519 | |||
| 54 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8967979 | |||
| CHEMBL128 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10193663 | |||
| CHEMBL128 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10513577 | |||
| CHEMBL128 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10611634 | |||
| CHEMBL128 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 11040052 | |||
| CHEMBL128 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 1565658 | |||
| CHEMBL128 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8863519 | |||
| CHEMBL128 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8967979 | |||
| DB00669 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10193663 | |||
| DB00669 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10513577 | |||
| DB00669 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10611634 | |||
| DB00669 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 11040052 | |||
| DB00669 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 1565658 | |||
| DB00669 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8863519 | |||
| DB00669 | 3707 | 68 | None | -3 | 32 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8967979 | |||
| 10446 | 530 | 0 | None | -8 | 4 | Rat | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 458 | 9 | 2 | 7 | 1.8 | COc1cncnc1N1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)CS(=O)(=O)NC | 9050026 | |||
| 133081 | 530 | 0 | None | -8 | 4 | Rat | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 458 | 9 | 2 | 7 | 1.8 | COc1cncnc1N1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)CS(=O)(=O)NC | 9050026 | |||
| CHEMBL2110755 | 530 | 0 | None | -8 | 4 | Rat | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 458 | 9 | 2 | 7 | 1.8 | COc1cncnc1N1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)CS(=O)(=O)NC | 9050026 | |||
| 4806 | 4008 | 88 | None | -2 | 13 | Human | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 21486038 | |||
| 7351 | 4008 | 88 | None | -2 | 13 | Human | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 21486038 | |||
| 9966051 | 4008 | 88 | None | -2 | 13 | Human | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 21486038 | |||
| CHEMBL2104993 | 4008 | 88 | None | -2 | 13 | Human | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 21486038 | |||
| DB09068 | 4008 | 88 | None | -2 | 13 | Human | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 21486038 | |||
| 113 | 1852 | 14 | None | 39 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | 375 | 7 | 2 | 4 | 4.2 | CN(CCCc1cc(ccc1O)C(=O)Nc1ccc(cc1)c1ccncc1)C | 10513577 | |||
| 128018 | 1852 | 14 | None | 39 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | 375 | 7 | 2 | 4 | 4.2 | CN(CCCc1cc(ccc1O)C(=O)Nc1ccc(cc1)c1ccncc1)C | 10513577 | |||
| CHEMBL119264 | 1852 | 14 | None | 39 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | 375 | 7 | 2 | 4 | 4.2 | CN(CCCc1cc(ccc1O)C(=O)Nc1ccc(cc1)c1ccncc1)C | 10513577 | |||
| 10446 | 530 | 0 | None | -4 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 458 | 9 | 2 | 7 | 1.8 | COc1cncnc1N1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)CS(=O)(=O)NC | 9050026 | |||
| 133081 | 530 | 0 | None | -4 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 458 | 9 | 2 | 7 | 1.8 | COc1cncnc1N1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)CS(=O)(=O)NC | 9050026 | |||
| CHEMBL2110755 | 530 | 0 | None | -4 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 458 | 9 | 2 | 7 | 1.8 | COc1cncnc1N1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)CS(=O)(=O)NC | 9050026 | |||
| 2869 | 4152 | 89 | None | -8 | 7 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10193663 | |||
| 60 | 4152 | 89 | None | -8 | 7 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10193663 | |||
| 60857 | 4152 | 89 | None | -8 | 7 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10193663 | |||
| CHEMBL1185 | 4152 | 89 | None | -8 | 7 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10193663 | |||
| DB00315 | 4152 | 89 | None | -8 | 7 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10193663 | |||
| 1251 | 1692 | 30 | None | -1 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 243 | 2 | 4 | 2 | 2.1 | CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O | 9986723 | |||
| 7191 | 1692 | 30 | None | -1 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 243 | 2 | 4 | 2 | 2.1 | CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O | 9986723 | |||
| 77992 | 1692 | 30 | None | -1 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 243 | 2 | 4 | 2 | 2.1 | CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O | 9986723 | |||
| CHEMBL1279 | 1692 | 30 | None | -1 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 243 | 2 | 4 | 2 | 2.1 | CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O | 9986723 | |||
| DB00998 | 1692 | 30 | None | -1 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 243 | 2 | 4 | 2 | 2.1 | CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O | 9986723 | |||
| 40 | 1547 | 58 | None | -2 | 5 | Human | 8.0 | pKi | = | 8 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | 10193663 | |||
| 77993 | 1547 | 58 | None | -2 | 5 | Human | 8.0 | pKi | = | 8 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | 10193663 | |||
| 995 | 1547 | 58 | None | -2 | 5 | Human | 8.0 | pKi | = | 8 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | 10193663 | |||
| CHEMBL1510 | 1547 | 58 | None | -2 | 5 | Human | 8.0 | pKi | = | 8 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | 10193663 | |||
| DB00216 | 1547 | 58 | None | -2 | 5 | Human | 8.0 | pKi | = | 8 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | 10193663 | |||
| 5 | 139 | 72 | None | -41 | 54 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 1557407 | |||
| 5202 | 139 | 72 | None | -41 | 54 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 1557407 | |||
| CHEMBL39 | 139 | 72 | None | -41 | 54 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 1557407 | |||
| DB08839 | 139 | 72 | None | -41 | 54 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 1557407 | |||
| 1884 | 2735 | 58 | None | -3 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 10193663 | |||
| 4440 | 2735 | 58 | None | -3 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 10193663 | |||
| 45 | 2735 | 58 | None | -3 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 10193663 | |||
| CHEMBL1278 | 2735 | 58 | None | -3 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 10193663 | |||
| DB00952 | 2735 | 58 | None | -3 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 10193663 | |||
| 5 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10431754 | |||
| 5 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 11040052 | |||
| 5 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 1565658 | |||
| 5 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8957260 | |||
| 5 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9208142 | |||
| 5 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9776361 | |||
| 5202 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10431754 | |||
| 5202 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 11040052 | |||
| 5202 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 1565658 | |||
| 5202 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8957260 | |||
| 5202 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9208142 | |||
| 5202 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9776361 | |||
| CHEMBL39 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10431754 | |||
| CHEMBL39 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 11040052 | |||
| CHEMBL39 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 1565658 | |||
| CHEMBL39 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8957260 | |||
| CHEMBL39 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9208142 | |||
| CHEMBL39 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9776361 | |||
| DB08839 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10431754 | |||
| DB08839 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 11040052 | |||
| DB08839 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 1565658 | |||
| DB08839 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8957260 | |||
| DB08839 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9208142 | |||
| DB08839 | 139 | 72 | None | -11 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9776361 | |||
| 3231 | 3505 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 534 | 4 | 0 | 6 | 6.0 | CCN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1nnc(o1)C | 10443589 | |||
| 5311426 | 3505 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 534 | 4 | 0 | 6 | 6.0 | CCN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1nnc(o1)C | 10443589 | |||
| CHEMBL1628625 | 3505 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 534 | 4 | 0 | 6 | 6.0 | CCN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1nnc(o1)C | 10443589 | |||
| 130 | 3500 | 47 | None | -1 | 13 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 11040052 | |||
| 130 | 3500 | 47 | None | -1 | 13 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 9548813 | |||
| 130 | 3500 | 47 | None | -1 | 13 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 9776361 | |||
| 3378093 | 3500 | 47 | None | -1 | 13 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 11040052 | |||
| 3378093 | 3500 | 47 | None | -1 | 13 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 9548813 | |||
| 3378093 | 3500 | 47 | None | -1 | 13 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 9776361 | |||
| CHEMBL281350 | 3500 | 47 | None | -1 | 13 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 11040052 | |||
| CHEMBL281350 | 3500 | 47 | None | -1 | 13 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 9548813 | |||
| CHEMBL281350 | 3500 | 47 | None | -1 | 13 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 9776361 | |||
| 3221 | 1188 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 257 | 4 | 2 | 3 | 2.7 | CCCOc1ccc2c(n1)c(c[nH]2)C1=CCNCC1 | None | |||
| 4029677 | 1188 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 257 | 4 | 2 | 3 | 2.7 | CCCOc1ccc2c(n1)c(c[nH]2)C1=CCNCC1 | None | |||
| CHEMBL1570196 | 1188 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 257 | 4 | 2 | 3 | 2.7 | CCCOc1ccc2c(n1)c(c[nH]2)C1=CCNCC1 | None | |||
| 132059 | 2235 | 57 | None | -1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | Guide to Pharmacology | 411 | 7 | 3 | 6 | 2.7 | NCCc1c[nH]c2c1cc(cc2)c1onc(n1)Cc1ccc(cc1)NS(=O)(=O)C | 10513577 | |||
| 15 | 2235 | 57 | None | -1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | Guide to Pharmacology | 411 | 7 | 3 | 6 | 2.7 | NCCc1c[nH]c2c1cc(cc2)c1onc(n1)Cc1ccc(cc1)NS(=O)(=O)C | 10513577 | |||
| CHEMBL39317 | 2235 | 57 | None | -1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | Guide to Pharmacology | 411 | 7 | 3 | 6 | 2.7 | NCCc1c[nH]c2c1cc(cc2)c1onc(n1)Cc1ccc(cc1)NS(=O)(=O)C | 10513577 | |||
| 202 | 1508 | 77 | None | -1 | 30 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| 60835 | 1508 | 77 | None | -1 | 30 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| 972 | 1508 | 77 | None | -1 | 30 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| CHEMBL1175 | 1508 | 77 | None | -1 | 30 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| DB00476 | 1508 | 77 | None | -1 | 30 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| 119570 | 3159 | 96 | None | -660 | 40 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | |||
| 2233 | 3159 | 96 | None | -660 | 40 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | |||
| 953 | 3159 | 96 | None | -660 | 40 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | |||
| CHEMBL301265 | 3159 | 96 | None | -660 | 40 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | |||
| DB00413 | 3159 | 96 | None | -660 | 40 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | |||
| 228 | 445 | 28 | None | 1 | 24 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | None | |||
| 33 | 445 | 28 | None | 1 | 24 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | None | |||
| 6005 | 445 | 28 | None | 1 | 24 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | None | |||
| CHEMBL53 | 445 | 28 | None | 1 | 24 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | None | |||
| DB00714 | 445 | 28 | None | 1 | 24 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | None | |||
| 3337 | 206367 | 27 | None | -74 | 40 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
| 65801 | 206367 | 27 | None | -74 | 40 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
| 66264 | 206367 | 27 | None | -74 | 40 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
| 91452 | 206367 | 27 | None | -74 | 40 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
| CHEMBL87493 | 206367 | 27 | None | -74 | 40 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
| 179 | 400 | 115 | None | -43 | 49 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| 2159 | 400 | 115 | None | -43 | 49 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| 963 | 400 | 115 | None | -43 | 49 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| CHEMBL243712 | 400 | 115 | None | -43 | 49 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| DB06288 | 400 | 115 | None | -43 | 49 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| 2995 | 204405 | 53 | None | -3 | 23 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | |||
| CHEMBL1696 | 204405 | 53 | None | -3 | 23 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | |||
| CHEMBL72 | 204405 | 53 | None | -3 | 23 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | |||
| 29 | 792 | 0 | None | -7943 | 9 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 456 | 5 | 1 | 8 | 3.4 | Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1 | 12130738 | |||
| 9805719 | 792 | 0 | None | -7943 | 9 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 456 | 5 | 1 | 8 | 3.4 | Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1 | 12130738 | |||
| CHEMBL2027925 | 792 | 0 | None | -7943 | 9 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 456 | 5 | 1 | 8 | 3.4 | Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1 | 12130738 | |||
| 126 | 4070 | 8 | None | -1258 | 5 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 395 | 6 | 1 | 4 | 3.5 | COc1ccccc1N1CCN(CC1)C[C@@H](C(=O)NC(C)(C)C)c1ccccc1 | 9208142 | |||
| 6604840 | 4070 | 8 | None | -1258 | 5 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 395 | 6 | 1 | 4 | 3.5 | COc1ccccc1N1CCN(CC1)C[C@@H](C(=O)NC(C)(C)C)c1ccccc1 | 9208142 | |||
| CHEMBL38288 | 4070 | 8 | None | -1258 | 5 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 395 | 6 | 1 | 4 | 3.5 | COc1ccccc1N1CCN(CC1)C[C@@H](C(=O)NC(C)(C)C)c1ccccc1 | 9208142 | |||
| 219050 | 3373 | 25 | None | -7762 | 21 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 346 | 6 | 2 | 2 | 5.0 | Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 | 10431754 | |||
| 219050 | 3373 | 25 | None | -7762 | 21 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 346 | 6 | 2 | 2 | 5.0 | Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 | 12388666 | |||
| 52 | 3373 | 25 | None | -7762 | 21 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 346 | 6 | 2 | 2 | 5.0 | Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 | 10431754 | |||
| 52 | 3373 | 25 | None | -7762 | 21 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 346 | 6 | 2 | 2 | 5.0 | Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 | 12388666 | |||
| CHEMBL431367 | 3373 | 25 | None | -7762 | 21 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 346 | 6 | 2 | 2 | 5.0 | Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 | 10431754 | |||
| CHEMBL431367 | 3373 | 25 | None | -7762 | 21 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 346 | 6 | 2 | 2 | 5.0 | Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 | 12388666 | |||
| 1574 | 81 | 60 | None | -8 | 21 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | 1565658 | |||
| 218 | 81 | 60 | None | -8 | 21 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | 1565658 | |||
| CHEMBL266591 | 81 | 60 | None | -8 | 21 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | 1565658 | |||
| 242 | 470 | 124 | None | -380 | 51 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 12784105 | |||
| 34 | 470 | 124 | None | -380 | 51 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 12784105 | |||
| 60795 | 470 | 124 | None | -380 | 51 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 12784105 | |||
| CHEMBL1112 | 470 | 124 | None | -380 | 51 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 12784105 | |||
| DB01238 | 470 | 124 | None | -380 | 51 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 12784105 | |||
| 10 | 723 | 28 | None | -63 | 9 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 406 | 6 | 1 | 3 | 4.7 | Clc1cccc(c1)N1CCN(CC1)CC(C(c1ccccc1)c1ccccc1)O | 9303567 | |||
| 3654103 | 723 | 28 | None | -63 | 9 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 406 | 6 | 1 | 3 | 4.7 | Clc1cccc(c1)N1CCN(CC1)CC(C(c1ccccc1)c1ccccc1)O | 9303567 | |||
| CHEMBL534232 | 723 | 28 | None | -63 | 9 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 406 | 6 | 1 | 3 | 4.7 | Clc1cccc(c1)N1CCN(CC1)CC(C(c1ccccc1)c1ccccc1)O | 9303567 | |||
| 65 | 2070 | 0 | None | -2 | 2 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 316 | 7 | 3 | 3 | 3.0 | FCC(NC[C@H](COc1cccc2c1c1ccccc1[nH]2)O)C | 11512051 | |||
| 9995893 | 2070 | 0 | None | -2 | 2 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 316 | 7 | 3 | 3 | 3.0 | FCC(NC[C@H](COc1cccc2c1c1ccccc1[nH]2)O)C | 11512051 | |||
| CHEMBL418834 | 2070 | 0 | None | -2 | 2 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 316 | 7 | 3 | 3 | 3.0 | FCC(NC[C@H](COc1cccc2c1c1ccccc1[nH]2)O)C | 11512051 | |||
| 129 | 3440 | 10 | None | -2818 | 9 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 451 | 7 | 1 | 4 | 4.8 | N#Cc1ccc2c(c1)[C@H]1CN(C[C@@H]1CO2)CCCCNC(=O)c1ccc(cc1)c1ccccc1 | 10869410 | |||
| 9868452 | 3440 | 10 | None | -2818 | 9 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 451 | 7 | 1 | 4 | 4.8 | N#Cc1ccc2c(c1)[C@H]1CN(C[C@@H]1CO2)CCCCNC(=O)c1ccc(cc1)c1ccccc1 | 10869410 | |||
| CHEMBL65280 | 3440 | 10 | None | -2818 | 9 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 451 | 7 | 1 | 4 | 4.8 | N#Cc1ccc2c(c1)[C@H]1CN(C[C@@H]1CO2)CCCCNC(=O)c1ccc(cc1)c1ccccc1 | 10869410 | |||
| 135398737 | 958 | 93 | None | -151 | 89 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 8935801 | |||
| 38 | 958 | 93 | None | -151 | 89 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 8935801 | |||
| 722 | 958 | 93 | None | -151 | 89 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 8935801 | |||
| CHEMBL42 | 958 | 93 | None | -151 | 89 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 8935801 | |||
| DB00363 | 958 | 93 | None | -151 | 89 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 8935801 | |||
| 2181 | 3128 | 46 | None | -70 | 35 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | 8935801 | |||
| 4830 | 3128 | 46 | None | -70 | 35 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | 8935801 | |||
| 92 | 3128 | 46 | None | -70 | 35 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | 8935801 | |||
| CHEMBL440294 | 3128 | 46 | None | -70 | 35 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | 8935801 | |||
| DB09286 | 3128 | 46 | None | -70 | 35 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | 8935801 | |||
| 37 | 778 | 60 | None | -22 | 17 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | 12388666 | |||
| 460 | 778 | 60 | None | -22 | 17 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | 12388666 | |||
| 54746 | 778 | 60 | None | -22 | 17 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | 12388666 | |||
| CHEMBL1201087 | 778 | 60 | None | -22 | 17 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | 12388666 | |||
| DB00248 | 778 | 60 | None | -22 | 17 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | 12388666 | |||
| 18971832 | 2418 | 0 | None | -85 | 13 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 351 | 3 | 2 | 2 | 4.0 | CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C | 9395253 | |||
| 21 | 2418 | 0 | None | -85 | 13 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 351 | 3 | 2 | 2 | 4.0 | CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C | 9395253 | |||
| CHEMBL3186179 | 2418 | 0 | None | -85 | 13 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 351 | 3 | 2 | 2 | 4.0 | CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C | 9395253 | |||
| 135398745 | 2914 | 112 | None | -199 | 65 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 8935801 | |||
| 47 | 2914 | 112 | None | -199 | 65 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 8935801 | |||
| CHEMBL715 | 2914 | 112 | None | -199 | 65 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 8935801 | |||
| DB00334 | 2914 | 112 | None | -199 | 65 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 8935801 | |||
| 1150 | 3878 | 121 | None | -7 | 25 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 1565658 | |||
| 125 | 3878 | 121 | None | -7 | 25 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 1565658 | |||
| CHEMBL6640 | 3878 | 121 | None | -7 | 25 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 1565658 | |||
| DB08653 | 3878 | 121 | None | -7 | 25 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 1565658 | |||
| 31101 | 729 | 40 | None | -128 | 36 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | 12388666 | |||
| 35 | 729 | 40 | None | -128 | 36 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | 12388666 | |||
| 403 | 729 | 40 | None | -128 | 36 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | 12388666 | |||
| CHEMBL493 | 729 | 40 | None | -128 | 36 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | 12388666 | |||
| DB01200 | 729 | 40 | None | -128 | 36 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | 12388666 | |||
| 10358392 | 2084 | 0 | None | -10 | 2 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 316 | 7 | 3 | 3 | 3.0 | FCC(NC[C@@H](COc1cccc2c1c1ccccc1[nH]2)O)C | 11512051 | |||
| 66 | 2084 | 0 | None | -10 | 2 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 316 | 7 | 3 | 3 | 3.0 | FCC(NC[C@@H](COc1cccc2c1c1ccccc1[nH]2)O)C | 11512051 | |||
| CHEMBL326418 | 2084 | 0 | None | -10 | 2 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 316 | 7 | 3 | 3 | 3.0 | FCC(NC[C@@H](COc1cccc2c1c1ccccc1[nH]2)O)C | 11512051 | |||
| 115 | 3791 | 80 | None | -2 | 27 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 1565658 | |||
| 115 | 3791 | 80 | None | -2 | 27 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 8863519 | |||
| 4296 | 3791 | 80 | None | -2 | 27 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 1565658 | |||
| 4296 | 3791 | 80 | None | -2 | 27 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 8863519 | |||
| CHEMBL274866 | 3791 | 80 | None | -2 | 27 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 1565658 | |||
| CHEMBL274866 | 3791 | 80 | None | -2 | 27 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 8863519 | |||
| 114 | 2254 | 14 | None | - | 1 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 11040052 | |||
| 6426760 | 2254 | 14 | None | - | 1 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 11040052 | |||
| CHEMBL292779 | 2254 | 14 | None | - | 1 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 11040052 | |||
| 2105 | 3054 | 37 | None | -436 | 33 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | 12388666 | |||
| 47811 | 3054 | 37 | None | -436 | 33 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | 12388666 | |||
| 48 | 3054 | 37 | None | -436 | 33 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | 12388666 | |||
| CHEMBL531 | 3054 | 37 | None | -436 | 33 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | 12388666 | |||
| DB01186 | 3054 | 37 | None | -436 | 33 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | 12388666 | |||
| 2601 | 3780 | 33 | None | -87 | 21 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | 12388666 | |||
| 443951 | 3780 | 33 | None | -87 | 21 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | 12388666 | |||
| 56 | 3780 | 33 | None | -87 | 21 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | 12388666 | |||
| CHEMBL73151 | 3780 | 33 | None | -87 | 21 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | 12388666 | |||
| DB13399 | 3780 | 33 | None | -87 | 21 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | 12388666 | |||
| 10287730 | 3536 | 40 | None | -251 | 12 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 412 | 6 | 0 | 5 | 4.3 | Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2 | 15887956 | |||
| 77 | 3536 | 40 | None | -251 | 12 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 412 | 6 | 0 | 5 | 4.3 | Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2 | 15887956 | |||
| CHEMBL425190 | 3536 | 40 | None | -251 | 12 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 412 | 6 | 0 | 5 | 4.3 | Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2 | 15887956 | |||
| 475100 | 189 | 0 | None | -158 | 6 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 426 | 4 | 1 | 7 | 2.6 | OC1CCc2n(C1)c(=O)c(c(n2)C)CCN1CCC(CC1)c1noc2c1ccc(c2)F | 8935801 | |||
| 67 | 189 | 0 | None | -158 | 6 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 426 | 4 | 1 | 7 | 2.6 | OC1CCc2n(C1)c(=O)c(c(n2)C)CCN1CCC(CC1)c1noc2c1ccc(c2)F | 8935801 | |||
| CHEMBL3542429 | 189 | 0 | None | -158 | 6 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 426 | 4 | 1 | 7 | 2.6 | OC1CCc2n(C1)c(=O)c(c(n2)C)CCN1CCC(CC1)c1noc2c1ccc(c2)F | 8935801 | |||
| 136 | 3292 | 32 | None | -177 | 15 | Human | 7.0 | pKi | None | 7.0 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 1565658 | |||
| 136 | 3292 | 32 | None | -177 | 15 | Human | 7.0 | pKi | None | 7.0 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 8863519 | |||
| 223 | 3292 | 32 | None | -177 | 15 | Human | 7.0 | pKi | None | 7.0 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 1565658 | |||
| 223 | 3292 | 32 | None | -177 | 15 | Human | 7.0 | pKi | None | 7.0 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 8863519 | |||
| 643606 | 3292 | 32 | None | -177 | 15 | Human | 7.0 | pKi | None | 7.0 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 1565658 | |||
| 643606 | 3292 | 32 | None | -177 | 15 | Human | 7.0 | pKi | None | 7.0 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 8863519 | |||
| CHEMBL10347 | 3292 | 32 | None | -177 | 15 | Human | 7.0 | pKi | None | 7.0 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 1565658 | |||
| CHEMBL10347 | 3292 | 32 | None | -177 | 15 | Human | 7.0 | pKi | None | 7.0 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 8863519 | |||
| 2435 | 3590 | 83 | None | -128 | 48 | Human | 7.0 | pKi | None | 7 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 8935801 | |||
| 60149 | 3590 | 83 | None | -128 | 48 | Human | 7.0 | pKi | None | 7 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 8935801 | |||
| 98 | 3590 | 83 | None | -128 | 48 | Human | 7.0 | pKi | None | 7 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 8935801 | |||
| CHEMBL12713 | 3590 | 83 | None | -128 | 48 | Human | 7.0 | pKi | None | 7 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 8935801 | |||
| DB06144 | 3590 | 83 | None | -128 | 48 | Human | 7.0 | pKi | None | 7 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 8935801 | |||
| 134 | 2514 | 24 | None | -14 | 67 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 1565658 | |||
| 134 | 2514 | 24 | None | -14 | 67 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 8863519 | |||
| 1775 | 2514 | 24 | None | -14 | 67 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 1565658 | |||
| 1775 | 2514 | 24 | None | -14 | 67 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 8863519 | |||
| 9681 | 2514 | 24 | None | -14 | 67 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 1565658 | |||
| 9681 | 2514 | 24 | None | -14 | 67 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 8863519 | |||
| CHEMBL1065 | 2514 | 24 | None | -14 | 67 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 1565658 | |||
| CHEMBL1065 | 2514 | 24 | None | -14 | 67 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 8863519 | |||
| DB00247 | 2514 | 24 | None | -14 | 67 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 1565658 | |||
| DB00247 | 2514 | 24 | None | -14 | 67 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 8863519 | |||
| 102 | 4127 | 48 | None | -64 | 49 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 10611634 | |||
| 102 | 4127 | 48 | None | -64 | 49 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 1565658 | |||
| 3659 | 4127 | 48 | None | -64 | 49 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 10611634 | |||
| 3659 | 4127 | 48 | None | -64 | 49 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 1565658 | |||
| 8969 | 4127 | 48 | None | -64 | 49 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 10611634 | |||
| 8969 | 4127 | 48 | None | -64 | 49 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 1565658 | |||
| CHEMBL15245 | 4127 | 48 | None | -64 | 49 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 10611634 | |||
| CHEMBL15245 | 4127 | 48 | None | -64 | 49 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 1565658 | |||
| DB01392 | 4127 | 48 | None | -64 | 49 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 10611634 | |||
| DB01392 | 4127 | 48 | None | -64 | 49 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 1565658 | |||
| 133 | 2496 | 52 | None | -23 | 42 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 8863519 | |||
| 1723 | 2496 | 52 | None | -23 | 42 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 8863519 | |||
| 28693 | 2496 | 52 | None | -23 | 42 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 8863519 | |||
| CHEMBL19215 | 2496 | 52 | None | -23 | 42 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 8863519 | |||
| DB13520 | 2496 | 52 | None | -23 | 42 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 8863519 | |||
| 103 | 4153 | 61 | None | -48 | 53 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 8935801 | |||
| 2875 | 4153 | 61 | None | -48 | 53 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 8935801 | |||
| 5736 | 4153 | 61 | None | -48 | 53 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 8935801 | |||
| CHEMBL285802 | 4153 | 61 | None | -48 | 53 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 8935801 | |||
| DB09225 | 4153 | 61 | None | -48 | 53 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 8935801 | |||
| 3652 | 4097 | 79 | None | -3 | 18 | Human | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | 9884068 | |||
| 57 | 4097 | 79 | None | -3 | 18 | Human | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | 9884068 | |||
| 60809 | 4097 | 79 | None | -3 | 18 | Human | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | 9884068 | |||
| CHEMBL21536 | 4097 | 79 | None | -3 | 18 | Human | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | 9884068 | |||
| DB15357 | 4097 | 79 | None | -3 | 18 | Human | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | 9884068 | |||
| 107 | 141 | 121 | None | -16 | 30 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 1565658 | |||
| 107 | 141 | 121 | None | -16 | 30 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 8863519 | |||
| 1833 | 141 | 121 | None | -16 | 30 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 1565658 | |||
| 1833 | 141 | 121 | None | -16 | 30 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 8863519 | |||
| CHEMBL8165 | 141 | 121 | None | -16 | 30 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 1565658 | |||
| CHEMBL8165 | 141 | 121 | None | -16 | 30 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 8863519 | |||
| 122 | 1437 | 9 | None | -5 | 11 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 287 | 8 | 2 | 2 | 2.9 | CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N | 1565658 | |||
| 156314 | 1437 | 9 | None | -5 | 11 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 287 | 8 | 2 | 2 | 2.9 | CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N | 1565658 | |||
| CHEMBL1332062 | 1437 | 9 | None | -5 | 11 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 287 | 8 | 2 | 2 | 2.9 | CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N | 1565658 | |||
| 1588 | 2325 | 27 | None | -42 | 44 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 12388666 | |||
| 28864 | 2325 | 27 | None | -42 | 44 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 12388666 | |||
| 43 | 2325 | 27 | None | -42 | 44 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 12388666 | |||
| CHEMBL157138 | 2325 | 27 | None | -42 | 44 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 12388666 | |||
| DB00589 | 2325 | 27 | None | -42 | 44 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 12388666 | |||
| 4106 | 2502 | 22 | None | -11 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10513577 | |||
| 4106 | 2502 | 22 | None | -11 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 11040052 | |||
| 4106 | 2502 | 22 | None | -11 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 8863519 | |||
| 4106 | 2502 | 22 | None | -11 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 8957260 | |||
| 5358812 | 2502 | 22 | None | -11 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10513577 | |||
| 5358812 | 2502 | 22 | None | -11 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 11040052 | |||
| 5358812 | 2502 | 22 | None | -11 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 8863519 | |||
| 5358812 | 2502 | 22 | None | -11 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 8957260 | |||
| 89 | 2502 | 22 | None | -11 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10513577 | |||
| 89 | 2502 | 22 | None | -11 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 11040052 | |||
| 89 | 2502 | 22 | None | -11 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 8863519 | |||
| 89 | 2502 | 22 | None | -11 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 8957260 | |||
| CHEMBL93240 | 2502 | 22 | None | -11 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10513577 | |||
| CHEMBL93240 | 2502 | 22 | None | -11 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 11040052 | |||
| CHEMBL93240 | 2502 | 22 | None | -11 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 8863519 | |||
| CHEMBL93240 | 2502 | 22 | None | -11 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 8957260 | |||
| 1342 | 35 | 49 | None | -4 | 19 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 1565658 | |||
| 1342 | 35 | 49 | None | -4 | 19 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 8863519 | |||
| 1342 | 35 | 49 | None | -4 | 19 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 9397179 | |||
| 3 | 35 | 49 | None | -4 | 19 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 1565658 | |||
| 3 | 35 | 49 | None | -4 | 19 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 8863519 | |||
| 3 | 35 | 49 | None | -4 | 19 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 9397179 | |||
| CHEMBL277120 | 35 | 49 | None | -4 | 19 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 1565658 | |||
| CHEMBL277120 | 35 | 49 | None | -4 | 19 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 8863519 | |||
| CHEMBL277120 | 35 | 49 | None | -4 | 19 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 9397179 | |||
| 108 | 669 | 0 | None | - | 1 | Human | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | 369 | 6 | 1 | 5 | 2.9 | COc1cncnc1N1CCN(CC1)CCCc1c[nH]c2c1cc(F)cc2 | 11040052 | |||
| 177836 | 669 | 0 | None | - | 1 | Human | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | 369 | 6 | 1 | 5 | 2.9 | COc1cncnc1N1CCN(CC1)CCCc1c[nH]c2c1cc(F)cc2 | 11040052 | |||
| 10296414 | 3531 | 15 | None | -7 | 9 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 15887956 | |||
| 76 | 3531 | 15 | None | -7 | 9 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 15887956 | |||
| CHEMBL183460 | 3531 | 15 | None | -7 | 9 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 431 | 6 | 1 | 5 | 4.2 | O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C | 15887956 | |||
| 1809 | 134 | 32 | None | -97 | 36 | Mouse | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 1557407 | |||
| 4 | 134 | 32 | None | -97 | 36 | Mouse | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 1557407 | |||
| CHEMBL18840 | 134 | 32 | None | -97 | 36 | Mouse | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 1557407 | |||
| 163091 | 494 | 34 | None | -131 | 10 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 285 | 0 | 0 | 2 | 4.3 | Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C | 8935801 | |||
| 22 | 494 | 34 | None | -131 | 10 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 285 | 0 | 0 | 2 | 4.3 | Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C | 8935801 | |||
| CHEMBL504548 | 494 | 34 | None | -131 | 10 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 285 | 0 | 0 | 2 | 4.3 | Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C | 8935801 | |||
| 132 | 1275 | 13 | None | -125 | 15 | Mouse | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | 1557407 | |||
| 155346 | 1275 | 13 | None | -125 | 15 | Mouse | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | 1557407 | |||
| CHEMBL378501 | 1275 | 13 | None | -125 | 15 | Mouse | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 287 | 5 | 3 | 4 | 2.2 | N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2 | 1557407 | |||
| 127 | 3126 | 52 | None | -18 | 15 | Mouse | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 248 | 6 | 3 | 3 | 1.9 | O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C | 1557407 | |||
| 688095 | 3126 | 52 | None | -18 | 15 | Mouse | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 248 | 6 | 3 | 3 | 1.9 | O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C | 1557407 | |||
| CHEMBL117405 | 3126 | 52 | None | -18 | 15 | Mouse | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 248 | 6 | 3 | 3 | 1.9 | O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C | 1557407 | |||
| 108029 | 3414 | 57 | None | -7 | 13 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 228 | 2 | 2 | 2 | 2.6 | COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1 | 1557407 | |||
| 23 | 3414 | 57 | None | -7 | 13 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 228 | 2 | 2 | 2 | 2.6 | COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1 | 1557407 | |||
| CHEMBL18785 | 3414 | 57 | None | -7 | 13 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 228 | 2 | 2 | 2 | 2.6 | COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1 | 1557407 | |||
| 75 | 3514 | 7 | None | -3 | 3 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 497 | 3 | 1 | 4 | 5.9 | CN1CCN(CC1)c1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(c2c1cccc2)c1ccncc1 | 11454652 | |||
| 9870500 | 3514 | 7 | None | -3 | 3 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 497 | 3 | 1 | 4 | 5.9 | CN1CCN(CC1)c1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(c2c1cccc2)c1ccncc1 | 11454652 | |||
| CHEMBL191971 | 3514 | 7 | None | -3 | 3 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 497 | 3 | 1 | 4 | 5.9 | CN1CCN(CC1)c1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(c2c1cccc2)c1ccncc1 | 11454652 | |||
| 123 | 2430 | 41 | None | -10 | 3 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 254 | 1 | 2 | 2 | 2.0 | OC[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3 | 1565658 | |||
| 123 | 2430 | 41 | None | -10 | 3 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 254 | 1 | 2 | 2 | 2.0 | OC[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3 | 8863519 | |||
| 14987 | 2430 | 41 | None | -10 | 3 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 254 | 1 | 2 | 2 | 2.0 | OC[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3 | 1565658 | |||
| 14987 | 2430 | 41 | None | -10 | 3 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 254 | 1 | 2 | 2 | 2.0 | OC[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3 | 8863519 | |||
| CHEMBL39947 | 2430 | 41 | None | -10 | 3 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 254 | 1 | 2 | 2 | 2.0 | OC[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3 | 1565658 | |||
| CHEMBL39947 | 2430 | 41 | None | -10 | 3 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 254 | 1 | 2 | 2 | 2.0 | OC[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3 | 8863519 | |||
| 106 | 148 | 26 | None | 4 | 6 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 302 | 11 | 2 | 2 | 4.8 | CCCCCCCCCOc1ccc2c(c1)c(CCN)c[nH]2 | 10513577 | |||
| 1797 | 148 | 26 | None | 4 | 6 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 302 | 11 | 2 | 2 | 4.8 | CCCCCCCCCOc1ccc2c(c1)c(CCN)c[nH]2 | 10513577 | |||
| CHEMBL97450 | 148 | 26 | None | 4 | 6 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 302 | 11 | 2 | 2 | 4.8 | CCCCCCCCCOc1ccc2c(c1)c(CCN)c[nH]2 | 10513577 | |||
| 1809 | 134 | 32 | None | -15 | 36 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 1565658 | |||
| 1809 | 134 | 32 | None | -15 | 36 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 8863519 | |||
| 4 | 134 | 32 | None | -15 | 36 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 1565658 | |||
| 4 | 134 | 32 | None | -15 | 36 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 8863519 | |||
| CHEMBL18840 | 134 | 32 | None | -15 | 36 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 1565658 | |||
| CHEMBL18840 | 134 | 32 | None | -15 | 36 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 8863519 | |||
| 1524 | 2181 | 96 | None | -4 | 52 | Mouse | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 1557407 | |||
| 197 | 2181 | 96 | None | -4 | 52 | Mouse | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 1557407 | |||
| 3822 | 2181 | 96 | None | -4 | 52 | Mouse | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 1557407 | |||
| 88 | 2181 | 96 | None | -4 | 52 | Mouse | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 1557407 | |||
| CHEMBL51 | 2181 | 96 | None | -4 | 52 | Mouse | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 1557407 | |||
| DB12465 | 2181 | 96 | None | -4 | 52 | Mouse | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 1557407 | |||
| 135 | 2532 | 43 | None | -3 | 58 | Mouse | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 1557407 | |||
| 1796 | 2532 | 43 | None | -3 | 58 | Mouse | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 1557407 | |||
| 4184 | 2532 | 43 | None | -3 | 58 | Mouse | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 1557407 | |||
| CHEMBL6437 | 2532 | 43 | None | -3 | 58 | Mouse | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 1557407 | |||
| DB06148 | 2532 | 43 | None | -3 | 58 | Mouse | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 1557407 | |||
| 2470 | 3653 | 50 | None | -194 | 59 | Mouse | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 1557407 | |||
| 3300 | 3653 | 50 | None | -194 | 59 | Mouse | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 1557407 | |||
| 5265 | 3653 | 50 | None | -194 | 59 | Mouse | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 1557407 | |||
| 99 | 3653 | 50 | None | -194 | 59 | Mouse | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 1557407 | |||
| CHEMBL267930 | 3653 | 50 | None | -194 | 59 | Mouse | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 1557407 | |||
| 102 | 4127 | 48 | None | -186 | 49 | Mouse | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 1557407 | |||
| 3659 | 4127 | 48 | None | -186 | 49 | Mouse | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 1557407 | |||
| 8969 | 4127 | 48 | None | -186 | 49 | Mouse | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 1557407 | |||
| CHEMBL15245 | 4127 | 48 | None | -186 | 49 | Mouse | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 1557407 | |||
| DB01392 | 4127 | 48 | None | -186 | 49 | Mouse | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 1557407 | |||
| 2865 | 4143 | 73 | None | -12 | 53 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 8935801 | |||
| 59 | 4143 | 73 | None | -12 | 53 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 8935801 | |||
| 60854 | 4143 | 73 | None | -12 | 53 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 8935801 | |||
| CHEMBL708 | 4143 | 73 | None | -12 | 53 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 8935801 | |||
| DB00246 | 4143 | 73 | None | -12 | 53 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 8935801 | |||
| 109 | 902 | 31 | None | -1 | 7 | Human | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | 334 | 1 | 0 | 4 | 3.3 | CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F | 10513577 | |||
| 109 | 902 | 31 | None | -1 | 7 | Human | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | 334 | 1 | 0 | 4 | 3.3 | CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F | 1565658 | |||
| 2689 | 902 | 31 | None | -1 | 7 | Human | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | 334 | 1 | 0 | 4 | 3.3 | CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F | 10513577 | |||
| 2689 | 902 | 31 | None | -1 | 7 | Human | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | 334 | 1 | 0 | 4 | 3.3 | CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F | 1565658 | |||
| CHEMBL27403 | 902 | 31 | None | -1 | 7 | Human | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | 334 | 1 | 0 | 4 | 3.3 | CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F | 10513577 | |||
| CHEMBL27403 | 902 | 31 | None | -1 | 7 | Human | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | 334 | 1 | 0 | 4 | 3.3 | CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F | 1565658 | |||
| 128 | 149 | 11 | None | -2 | 8 | Mouse | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)cccc2O)CCC | 1557407 | |||
| 172267 | 149 | 11 | None | -2 | 8 | Mouse | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)cccc2O)CCC | 1557407 | |||
| CHEMBL273273 | 149 | 11 | None | -2 | 8 | Mouse | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)cccc2O)CCC | 1557407 | |||
| 10531 | 1420 | 21 | None | -12 | 23 | Human | 8.6 | pKi | None | 8.6 | Binding | Guide to Pharmacology | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8863519 | |||
| 10531 | 1420 | 21 | None | -12 | 23 | Human | 8.6 | pKi | None | 8.6 | Binding | Guide to Pharmacology | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8967979 | |||
| 121 | 1420 | 21 | None | -12 | 23 | Human | 8.6 | pKi | None | 8.6 | Binding | Guide to Pharmacology | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8863519 | |||
| 121 | 1420 | 21 | None | -12 | 23 | Human | 8.6 | pKi | None | 8.6 | Binding | Guide to Pharmacology | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8967979 | |||
| 888 | 1420 | 21 | None | -12 | 23 | Human | 8.6 | pKi | None | 8.6 | Binding | Guide to Pharmacology | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8863519 | |||
| 888 | 1420 | 21 | None | -12 | 23 | Human | 8.6 | pKi | None | 8.6 | Binding | Guide to Pharmacology | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8967979 | |||
| CHEMBL1732 | 1420 | 21 | None | -12 | 23 | Human | 8.6 | pKi | None | 8.6 | Binding | Guide to Pharmacology | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8863519 | |||
| CHEMBL1732 | 1420 | 21 | None | -12 | 23 | Human | 8.6 | pKi | None | 8.6 | Binding | Guide to Pharmacology | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8967979 | |||
| DB00320 | 1420 | 21 | None | -12 | 23 | Human | 8.6 | pKi | None | 8.6 | Binding | Guide to Pharmacology | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8863519 | |||
| DB00320 | 1420 | 21 | None | -12 | 23 | Human | 8.6 | pKi | None | 8.6 | Binding | Guide to Pharmacology | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8967979 | |||
| 14533720 | 182 | 0 | None | -3 | 3 | Human | 8.7 | pKi | None | 8.7 | Binding | Guide to Pharmacology | 275 | 6 | 1 | 3 | 2.2 | O=C(OCC1OC1)NCC[Si]([Si](C)(C)C)(C)C | 9397179 | |||
| 6 | 182 | 0 | None | -3 | 3 | Human | 8.7 | pKi | None | 8.7 | Binding | Guide to Pharmacology | 275 | 6 | 1 | 3 | 2.2 | O=C(OCC1OC1)NCC[Si]([Si](C)(C)C)(C)C | 9397179 | |||
| 117 | 353 | 19 | None | -1 | 2 | Human | 8.9 | pKi | None | 8.9 | Binding | Guide to Pharmacology | 302 | 6 | 3 | 5 | 1.3 | C(NC[C@H]1CCc2c(O1)cccc2)CCNC1=NCCCN1 | 8967979 | |||
| 120 | 353 | 19 | None | -1 | 2 | Human | 8.9 | pKi | None | 8.9 | Binding | Guide to Pharmacology | 302 | 6 | 3 | 5 | 1.3 | C(NC[C@H]1CCc2c(O1)cccc2)CCNC1=NCCCN1 | 8967979 | |||
| 66004 | 353 | 19 | None | -1 | 2 | Human | 8.9 | pKi | None | 8.9 | Binding | Guide to Pharmacology | 302 | 6 | 3 | 5 | 1.3 | C(NC[C@H]1CCc2c(O1)cccc2)CCNC1=NCCCN1 | 8967979 | |||
| CHEMBL88240 | 353 | 19 | None | -1 | 2 | Human | 8.9 | pKi | None | 8.9 | Binding | Guide to Pharmacology | 302 | 6 | 3 | 5 | 1.3 | C(NC[C@H]1CCc2c(O1)cccc2)CCNC1=NCCCN1 | 8967979 | |||
| 28 | 3496 | 46 | None | 13 | 10 | Human | 9.0 | pKi | None | 9 | Binding | Guide to Pharmacology | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 9303567 | |||
| 3292447 | 3496 | 46 | None | 13 | 10 | Human | 9.0 | pKi | None | 9 | Binding | Guide to Pharmacology | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 9303567 | |||
| CHEMBL20963 | 3496 | 46 | None | 13 | 10 | Human | 9.0 | pKi | None | 9 | Binding | Guide to Pharmacology | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 9303567 | |||
| 107780 | 1844 | 54 | None | 1 | 17 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10513577 | |||
| 14 | 1844 | 54 | None | 1 | 17 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10513577 | |||
| CHEMBL15928 | 1844 | 54 | None | 1 | 17 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10513577 | |||
| 107780 | 1844 | 54 | None | 1 | 17 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 8957260 | |||
| 107780 | 1844 | 54 | None | 1 | 17 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 9303567 | |||
| 107780 | 1844 | 54 | None | 1 | 17 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 9397179 | |||
| 107780 | 1844 | 54 | None | 1 | 17 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 9548813 | |||
| 107780 | 1844 | 54 | None | 1 | 17 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 9776361 | |||
| 14 | 1844 | 54 | None | 1 | 17 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 8957260 | |||
| 14 | 1844 | 54 | None | 1 | 17 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 9303567 | |||
| 14 | 1844 | 54 | None | 1 | 17 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 9397179 | |||
| 14 | 1844 | 54 | None | 1 | 17 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 9548813 | |||
| 14 | 1844 | 54 | None | 1 | 17 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 9776361 | |||
| CHEMBL15928 | 1844 | 54 | None | 1 | 17 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 8957260 | |||
| CHEMBL15928 | 1844 | 54 | None | 1 | 17 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 9303567 | |||
| CHEMBL15928 | 1844 | 54 | None | 1 | 17 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 9397179 | |||
| CHEMBL15928 | 1844 | 54 | None | 1 | 17 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 9548813 | |||
| CHEMBL15928 | 1844 | 54 | None | 1 | 17 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 9776361 | |||
| 197706 | 1464 | 0 | None | -1 | 10 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 403 | 6 | 2 | 5 | 2.3 | NCCc1c[nH]c2c1cc(OCC(=O)N1CCN(CC1)c1ccc(cc1)C#N)cc2 | 10381763 | |||
| 39 | 1464 | 0 | None | -1 | 10 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 403 | 6 | 2 | 5 | 2.3 | NCCc1c[nH]c2c1cc(OCC(=O)N1CCN(CC1)c1ccc(cc1)C#N)cc2 | 10381763 | |||
| CHEMBL1742428 | 1464 | 0 | None | -1 | 10 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 403 | 6 | 2 | 5 | 2.3 | NCCc1c[nH]c2c1cc(OCC(=O)N1CCN(CC1)c1ccc(cc1)C#N)cc2 | 10381763 | |||
| 124 | 2981 | 47 | None | 1 | 33 | Human | 9.5 | pKi | None | 9.5 | Binding | Guide to Pharmacology | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | 9632357 | |||
| 2032 | 2981 | 47 | None | 1 | 33 | Human | 9.5 | pKi | None | 9.5 | Binding | Guide to Pharmacology | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | 9632357 | |||
| 4636 | 2981 | 47 | None | 1 | 33 | Human | 9.5 | pKi | None | 9.5 | Binding | Guide to Pharmacology | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | 9632357 | |||
| CHEMBL762 | 2981 | 47 | None | 1 | 33 | Human | 9.5 | pKi | None | 9.5 | Binding | Guide to Pharmacology | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | 9632357 | |||
| DB00935 | 2981 | 47 | None | 1 | 33 | Human | 9.5 | pKi | None | 9.5 | Binding | Guide to Pharmacology | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | 9632357 | |||
| 197706 | 1464 | 0 | None | 1 | 10 | Rat | 9.7 | pKi | None | 9.7 | Binding | Guide to Pharmacology | 403 | 6 | 2 | 5 | 2.3 | NCCc1c[nH]c2c1cc(OCC(=O)N1CCN(CC1)c1ccc(cc1)C#N)cc2 | 10381763 | |||
| 39 | 1464 | 0 | None | 1 | 10 | Rat | 9.7 | pKi | None | 9.7 | Binding | Guide to Pharmacology | 403 | 6 | 2 | 5 | 2.3 | NCCc1c[nH]c2c1cc(OCC(=O)N1CCN(CC1)c1ccc(cc1)C#N)cc2 | 10381763 | |||
| CHEMBL1742428 | 1464 | 0 | None | 1 | 10 | Rat | 9.7 | pKi | None | 9.7 | Binding | Guide to Pharmacology | 403 | 6 | 2 | 5 | 2.3 | NCCc1c[nH]c2c1cc(OCC(=O)N1CCN(CC1)c1ccc(cc1)C#N)cc2 | 10381763 | |||