Ligand source activities (1 row/activity)





Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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DOI

11120893 11294 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
ChEMBL 324 3 2 4 3.2 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccoc4)nc23)CC1 10.1021/jm030020m
CHEMBL102250 11294 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
ChEMBL 324 3 2 4 3.2 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccoc4)nc23)CC1 10.1021/jm030020m
10925382 11788 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
ChEMBL 324 3 2 4 3.2 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccco4)nc23)CC1 10.1021/jm030020m
CHEMBL105091 11788 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
ChEMBL 324 3 2 4 3.2 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccco4)nc23)CC1 10.1021/jm030020m
11759467 11941 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
ChEMBL 335 3 2 4 3.0 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccncc4)nc23)CC1 10.1021/jm030020m
CHEMBL105958 11941 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
ChEMBL 335 3 2 4 3.0 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccncc4)nc23)CC1 10.1021/jm030020m
10308815 130256 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assayAgonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assay
ChEMBL 341 4 1 4 3.0 CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)n2)CC1 10.1016/j.bmcl.2015.07.042
CHEMBL3617557 130256 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assayAgonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assay
ChEMBL 341 4 1 4 3.0 CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)n2)CC1 10.1016/j.bmcl.2015.07.042
11044798 11940 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
ChEMBL 300 4 2 3 3.1 CCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
CHEMBL105955 11940 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
ChEMBL 300 4 2 3 3.1 CCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
11372635 73861 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Stimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cellsStimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cells
ChEMBL 387 3 1 4 4.7 CN1CCC(c2noc3ccc(NC(=O)c4ccc(F)cc4Cl)cc23)CC1 10.1016/j.bmcl.2004.09.079
CHEMBL187308 73861 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Stimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cellsStimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cells
ChEMBL 387 3 1 4 4.7 CN1CCC(c2noc3ccc(NC(=O)c4ccc(F)cc4Cl)cc23)CC1 10.1016/j.bmcl.2004.09.079
11056946 115670 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
ChEMBL 340 3 2 4 3.7 CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccs4)nc23)CC1 10.1021/jm030020m
CHEMBL321080 115670 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
ChEMBL 340 3 2 4 3.7 CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccs4)nc23)CC1 10.1021/jm030020m
10946905 170461 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
ChEMBL 312 3 2 3 3.1 CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCC4)nc23)CC1 10.1021/jm030020m
CHEMBL420475 170461 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
ChEMBL 312 3 2 3 3.1 CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCC4)nc23)CC1 10.1021/jm030020m
11110452 11902 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
ChEMBL 335 3 2 4 3.0 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccn4)nc23)CC1 10.1021/jm030020m
CHEMBL105722 11902 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
ChEMBL 335 3 2 4 3.0 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccn4)nc23)CC1 10.1021/jm030020m
44387174 68547 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Concentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptorConcentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptor
ChEMBL 387 3 1 4 4.7 CN1CCC(c2coc3ccc(NC(=O)c4ccc(F)cc4Cl)nc23)CC1 10.1016/j.bmcl.2003.09.091
CHEMBL177238 68547 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Concentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptorConcentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptor
ChEMBL 387 3 1 4 4.7 CN1CCC(c2coc3ccc(NC(=O)c4ccc(F)cc4Cl)nc23)CC1 10.1016/j.bmcl.2003.09.091
9947817 11819 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
ChEMBL 286 3 2 3 2.7 CCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
CHEMBL105261 11819 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
ChEMBL 286 3 2 3 2.7 CCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
11011968 11713 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
ChEMBL 298 3 2 3 2.7 CN1CCC(c2c[nH]c3ccc(NC(=O)C4CC4)nc23)CC1 10.1021/jm030020m
CHEMBL104720 11713 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
ChEMBL 298 3 2 3 2.7 CN1CCC(c2c[nH]c3ccc(NC(=O)C4CC4)nc23)CC1 10.1021/jm030020m
2543 10479 68 None -3 14 Human 7.5 pEC50 = 7.5 Functional
In vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1021/jm0155190
5358 10479 68 None -3 14 Human 7.5 pEC50 = 7.5 Functional
In vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1021/jm0155190
54 10479 68 None -3 14 Human 7.5 pEC50 = 7.5 Functional
In vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1021/jm0155190
CHEMBL128 10479 68 None -3 14 Human 7.5 pEC50 = 7.5 Functional
In vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1021/jm0155190
DB00669 10479 68 None -3 14 Human 7.5 pEC50 = 7.5 Functional
In vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1021/jm0155190
10445946 174642 4 None - 1 Human 7.4 pEC50 = 7.4 Functional
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-HT1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-HT1F receptor
ChEMBL 272 2 2 3 2.3 CC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
CHEMBL431041 174642 4 None - 1 Human 7.4 pEC50 = 7.4 Functional
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-HT1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-HT1F receptor
ChEMBL 272 2 2 3 2.3 CC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
44395894 73722 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Stimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cellsStimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cells
ChEMBL 371 3 1 4 4.2 CN1CCC(c2noc3ccc(NC(=O)c4ccc(F)cc4F)cc23)CC1 10.1016/j.bmcl.2004.09.079
CHEMBL186662 73722 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Stimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cellsStimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cells
ChEMBL 371 3 1 4 4.2 CN1CCC(c2noc3ccc(NC(=O)c4ccc(F)cc4F)cc23)CC1 10.1016/j.bmcl.2004.09.079
44395925 73921 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Stimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cellsStimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cells
ChEMBL 390 3 2 4 3.6 CN1CCC(N2CNc3ccc(NC(=O)c4c(F)cc(F)cc4F)cc32)CC1 10.1016/j.bmcl.2004.09.079
CHEMBL187581 73921 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Stimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cellsStimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cells
ChEMBL 390 3 2 4 3.6 CN1CCC(N2CNc3ccc(NC(=O)c4c(F)cc(F)cc4F)cc32)CC1 10.1016/j.bmcl.2004.09.079
122190350 130249 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assayAgonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assay
ChEMBL 358 4 1 3 3.7 CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2F)CC1 10.1016/j.bmcl.2015.07.042
CHEMBL3617550 130249 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assayAgonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assay
ChEMBL 358 4 1 3 3.7 CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2F)CC1 10.1016/j.bmcl.2015.07.042
44352308 124265 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
In vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 339 5 2 2 4.0 Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C 10.1021/jm0155190
CHEMBL339980 124265 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
In vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 339 5 2 2 4.0 Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C 10.1021/jm0155190
44395930 73783 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Stimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cellsStimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cells
ChEMBL 388 3 2 4 4.0 CN1CCC(N2CNc3ccc(NC(=O)c4ccc(F)cc4Cl)cc32)CC1 10.1016/j.bmcl.2004.09.079
CHEMBL186951 73783 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Stimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cellsStimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cells
ChEMBL 388 3 2 4 4.0 CN1CCC(N2CNc3ccc(NC(=O)c4ccc(F)cc4Cl)cc32)CC1 10.1016/j.bmcl.2004.09.079
9863365 68549 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Concentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptorConcentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptor
ChEMBL 353 3 1 4 4.0 CN1CCC(c2coc3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 10.1016/j.bmcl.2003.09.091
CHEMBL177258 68549 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Concentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptorConcentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptor
ChEMBL 353 3 1 4 4.0 CN1CCC(c2coc3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 10.1016/j.bmcl.2003.09.091
44386896 139063 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Concentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptorConcentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptor
ChEMBL 387 3 1 4 4.7 CN1CCC(c2coc3ccc(NC(=O)c4c(F)cccc4Cl)nc23)CC1 10.1016/j.bmcl.2003.09.091
CHEMBL369705 139063 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Concentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptorConcentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptor
ChEMBL 387 3 1 4 4.7 CN1CCC(c2coc3ccc(NC(=O)c4c(F)cccc4Cl)nc23)CC1 10.1016/j.bmcl.2003.09.091
5 6927 72 None -15 27 Human 8.1 pEC50 = 8.1 Functional
In vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm0155190
5202 6927 72 None -15 27 Human 8.1 pEC50 = 8.1 Functional
In vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm0155190
CHEMBL39 6927 72 None -15 27 Human 8.1 pEC50 = 8.1 Functional
In vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm0155190
DB08839 6927 72 None -15 27 Human 8.1 pEC50 = 8.1 Functional
In vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 10.1021/jm0155190
9798021 130248 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assayAgonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assay
ChEMBL 340 4 1 3 3.6 CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2)CC1 10.1016/j.bmcl.2015.07.042
CHEMBL3617549 130248 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assayAgonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assay
ChEMBL 340 4 1 3 3.6 CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2)CC1 10.1016/j.bmcl.2015.07.042
11046087 11719 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
ChEMBL 340 3 2 4 3.7 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccsc4)nc23)CC1 10.1021/jm030020m
CHEMBL104753 11719 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
ChEMBL 340 3 2 4 3.7 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccsc4)nc23)CC1 10.1021/jm030020m
10000386 66893 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Concentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptorConcentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptor
ChEMBL 389 3 1 4 4.3 CN1CCC(c2coc3ccc(NC(=O)c4c(F)cc(F)cc4F)nc23)CC1 10.1016/j.bmcl.2003.09.091
CHEMBL173949 66893 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Concentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptorConcentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptor
ChEMBL 389 3 1 4 4.3 CN1CCC(c2coc3ccc(NC(=O)c4c(F)cc(F)cc4F)nc23)CC1 10.1016/j.bmcl.2003.09.091
146420200 191660 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayAgonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assay
ChEMBL 360 3 1 4 3.8 CN1CCC(=C(F)c2cccc(NC(=O)c3ccc(Cl)cn3)n2)CC1 10.1016/j.ejmech.2021.113782
CHEMBL4852743 191660 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayAgonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assay
ChEMBL 360 3 1 4 3.8 CN1CCC(=C(F)c2cccc(NC(=O)c3ccc(Cl)cn3)n2)CC1 10.1016/j.ejmech.2021.113782
146420010 193113 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayAgonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assay
ChEMBL 393 4 1 3 4.5 CCN1CCC(=C(F)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1 10.1016/j.ejmech.2021.113782
CHEMBL4874958 193113 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayAgonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assay
ChEMBL 393 4 1 3 4.5 CCN1CCC(=C(F)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1 10.1016/j.ejmech.2021.113782
146420029 191541 0 None 60 6 Human 7.7 pIC50 = 7.7 Functional
Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayAgonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assay
ChEMBL 379 3 1 3 4.2 CN1CCC(=C(F)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1 10.1016/j.ejmech.2021.113782
CHEMBL4851044 191541 0 None 60 6 Human 7.7 pIC50 = 7.7 Functional
Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayAgonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assay
ChEMBL 379 3 1 3 4.2 CN1CCC(=C(F)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1 10.1016/j.ejmech.2021.113782
146420204 192498 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayAgonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assay
ChEMBL 377 3 1 3 4.5 CN1CCC(=C(F)c2cccc(NC(=O)c3ccc(Cl)cc3F)n2)CC1 10.1016/j.ejmech.2021.113782
CHEMBL4865700 192498 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayAgonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assay
ChEMBL 377 3 1 3 4.5 CN1CCC(=C(F)c2cccc(NC(=O)c3ccc(Cl)cc3F)n2)CC1 10.1016/j.ejmech.2021.113782
146420207 192161 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayAgonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assay
ChEMBL 344 3 1 4 3.3 CN1CCC(=C(F)c2cccc(NC(=O)c3ccc(F)cn3)n2)CC1 10.1016/j.ejmech.2021.113782
CHEMBL4860576 192161 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayAgonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assay
ChEMBL 344 3 1 4 3.3 CN1CCC(=C(F)c2cccc(NC(=O)c3ccc(F)cn3)n2)CC1 10.1016/j.ejmech.2021.113782
146420206 192289 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayAgonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assay
ChEMBL 359 3 1 3 4.4 CN1CCC(=C(F)c2cccc(NC(=O)c3ccc(Cl)cc3)n2)CC1 10.1016/j.ejmech.2021.113782
CHEMBL4862526 192289 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayAgonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assay
ChEMBL 359 3 1 3 4.4 CN1CCC(=C(F)c2cccc(NC(=O)c3ccc(Cl)cc3)n2)CC1 10.1016/j.ejmech.2021.113782
146420182 191297 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayAgonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assay
ChEMBL 361 3 1 3 4.0 CN1CCC(=C(F)c2cccc(NC(=O)c3ccc(F)cc3F)n2)CC1 10.1016/j.ejmech.2021.113782
CHEMBL4847626 191297 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayAgonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assay
ChEMBL 361 3 1 3 4.0 CN1CCC(=C(F)c2cccc(NC(=O)c3ccc(F)cc3F)n2)CC1 10.1016/j.ejmech.2021.113782
146420009 192948 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayAgonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assay
ChEMBL 405 4 1 3 4.7 O=C(Nc1cccc(C(F)=C2CCN(C3CC3)CC2)n1)c1c(F)cc(F)cc1F 10.1016/j.ejmech.2021.113782
CHEMBL4872571 192948 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayAgonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assay
ChEMBL 405 4 1 3 4.7 O=C(Nc1cccc(C(F)=C2CCN(C3CC3)CC2)n1)c1c(F)cc(F)cc1F 10.1016/j.ejmech.2021.113782
146420181 191244 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayAgonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assay
ChEMBL 343 3 1 3 3.9 CN1CCC(=C(F)c2cccc(NC(=O)c3ccc(F)cc3)n2)CC1 10.1016/j.ejmech.2021.113782
CHEMBL4846825 191244 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayAgonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assay
ChEMBL 343 3 1 3 3.9 CN1CCC(=C(F)c2cccc(NC(=O)c3ccc(F)cc3)n2)CC1 10.1016/j.ejmech.2021.113782
164620307 192850 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayAgonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assay
ChEMBL 415 4 1 3 4.8 O=C(Nc1cccc(C(F)=C2CCN(C(F)F)CC2)n1)c1c(F)cc(F)cc1F 10.1016/j.ejmech.2021.113782
CHEMBL4871295 192850 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayAgonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assay
ChEMBL 415 4 1 3 4.8 O=C(Nc1cccc(C(F)=C2CCN(C(F)F)CC2)n1)c1c(F)cc(F)cc1F 10.1016/j.ejmech.2021.113782
11610526 9062 64 None - 1 Human 7.1 pIC50 = 7.1 Functional
Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayAgonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assay
ChEMBL 377 4 1 4 3.3 CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F 10.1016/j.ejmech.2021.113782
3928 9062 64 None - 1 Human 7.1 pIC50 = 7.1 Functional
Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayAgonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assay
ChEMBL 377 4 1 4 3.3 CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F 10.1016/j.ejmech.2021.113782
5351 9062 64 None - 1 Human 7.1 pIC50 = 7.1 Functional
Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayAgonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assay
ChEMBL 377 4 1 4 3.3 CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F 10.1016/j.ejmech.2021.113782
CHEMBL3039520 9062 64 None - 1 Human 7.1 pIC50 = 7.1 Functional
Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayAgonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assay
ChEMBL 377 4 1 4 3.3 CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F 10.1016/j.ejmech.2021.113782
DB11732 9062 64 None - 1 Human 7.1 pIC50 = 7.1 Functional
Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayAgonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assay
ChEMBL 377 4 1 4 3.3 CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F 10.1016/j.ejmech.2021.113782
102 10899 48 None -8 20 Rat 8.2 pIC50 = 8.2 Functional
NoneNone
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
3659 10899 48 None -8 20 Rat 8.2 pIC50 = 8.2 Functional
NoneNone
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
8969 10899 48 None -8 20 Rat 8.2 pIC50 = 8.2 Functional
NoneNone
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
CHEMBL15245 10899 48 None -8 20 Rat 8.2 pIC50 = 8.2 Functional
NoneNone
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
DB01392 10899 48 None -8 20 Rat 8.2 pIC50 = 8.2 Functional
NoneNone
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
11954224 222732 0 None -1 5 Rat 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
134 9292 24 None -5 18 Rat 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1775 9292 24 None -5 18 Rat 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681 9292 24 None -5 18 Rat 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
CHEMBL1065 9292 24 None -5 18 Rat 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
DB00247 9292 24 None -5 18 Rat 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
2543 10479 68 None -3 14 Human 7.2 pIC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 8384716
5358 10479 68 None -3 14 Human 7.2 pIC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 8384716
54 10479 68 None -3 14 Human 7.2 pIC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 8384716
CHEMBL128 10479 68 None -3 14 Human 7.2 pIC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 8384716
DB00669 10479 68 None -3 14 Human 7.2 pIC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 8384716
1809 6922 32 None -8511 8 Rat 5.6 pIC50 None 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 8384716
4 6922 32 None -8511 8 Rat 5.6 pIC50 None 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 8384716
CHEMBL18840 6922 32 None -8511 8 Rat 5.6 pIC50 None 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 8384716
102 10899 48 None -8 20 Rat 6.2 pIC50 None 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 8384716
3659 10899 48 None -8 20 Rat 6.2 pIC50 None 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 8384716
8969 10899 48 None -8 20 Rat 6.2 pIC50 None 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 8384716
CHEMBL15245 10899 48 None -8 20 Rat 6.2 pIC50 None 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 8384716
DB01392 10899 48 None -8 20 Rat 6.2 pIC50 None 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 8384716
133 9274 52 None -1258 28 Rat 6.3 pIC50 None 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8384716
1723 9274 52 None -1258 28 Rat 6.3 pIC50 None 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8384716
28693 9274 52 None -1258 28 Rat 6.3 pIC50 None 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8384716
CHEMBL19215 9274 52 None -1258 28 Rat 6.3 pIC50 None 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8384716
DB13520 9274 52 None -1258 28 Rat 6.3 pIC50 None 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8384716
5 6927 72 None -120 27 Rat 7.2 pIC50 None 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 8384716
5202 6927 72 None -120 27 Rat 7.2 pIC50 None 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 8384716
CHEMBL39 6927 72 None -120 27 Rat 7.2 pIC50 None 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 8384716
DB08839 6927 72 None -120 27 Rat 7.2 pIC50 None 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 8384716
1043 8363 14 None -251 23 Rat 7.3 pIC50 None 7.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 8384716
149 8363 14 None -251 23 Rat 7.3 pIC50 None 7.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 8384716
8223 8363 14 None -251 23 Rat 7.3 pIC50 None 7.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 8384716
CHEMBL442 8363 14 None -251 23 Rat 7.3 pIC50 None 7.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 8384716
DB00696 8363 14 None -251 23 Rat 7.3 pIC50 None 7.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 8384716
134 9292 24 None -5 18 Rat 7.8 pIC50 None 7.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 8384716
1775 9292 24 None -5 18 Rat 7.8 pIC50 None 7.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 8384716
9681 9292 24 None -5 18 Rat 7.8 pIC50 None 7.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 8384716
CHEMBL1065 9292 24 None -5 18 Rat 7.8 pIC50 None 7.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 8384716
DB00247 9292 24 None -5 18 Rat 7.8 pIC50 None 7.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 8384716




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146420029 191541 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity to human 5HT1F receptorBinding affinity to human 5HT1F receptor
ChEMBL 379 3 1 3 4.2 CN1CCC(=C(F)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1 10.1016/j.ejmech.2021.113782
CHEMBL4851044 191541 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity to human 5HT1F receptorBinding affinity to human 5HT1F receptor
ChEMBL 379 3 1 3 4.2 CN1CCC(=C(F)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1 10.1016/j.ejmech.2021.113782
18366015 85147 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 1F receptorBinding affinity towards human recombinant 5-hydroxytryptamine 1F receptor
ChEMBL 313 4 2 3 2.6 CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1 10.1021/jm000956k
CHEMBL2110300 85147 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards human recombinant 5-hydroxytryptamine 1F receptorBinding affinity towards human recombinant 5-hydroxytryptamine 1F receptor
ChEMBL 313 4 2 3 2.6 CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1 10.1021/jm000956k
114 9034 14 None - 1 Human 5.4 pIC50 = 5.4 Binding
Compound was evaluated for the affinity at 5-hydroxytryptamine 1F receptorCompound was evaluated for the affinity at 5-hydroxytryptamine 1F receptor
ChEMBL 432 8 1 5 3.7 Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 10.1021/jm9704560
6426760 9034 14 None - 1 Human 5.4 pIC50 = 5.4 Binding
Compound was evaluated for the affinity at 5-hydroxytryptamine 1F receptorCompound was evaluated for the affinity at 5-hydroxytryptamine 1F receptor
ChEMBL 432 8 1 5 3.7 Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 10.1021/jm9704560
CHEMBL292779 9034 14 None - 1 Human 5.4 pIC50 = 5.4 Binding
Compound was evaluated for the affinity at 5-hydroxytryptamine 1F receptorCompound was evaluated for the affinity at 5-hydroxytryptamine 1F receptor
ChEMBL 432 8 1 5 3.7 Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 10.1021/jm9704560
151 9194 44 None 14 4 Human 8.8 pKi = 8.8 Binding
Binding affinity at human 5HT1F receptorBinding affinity at human 5HT1F receptor
ChEMBL 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F 10.1021/jm7011722
20 9194 44 None 14 4 Human 8.8 pKi = 8.8 Binding
Binding affinity at human 5HT1F receptorBinding affinity at human 5HT1F receptor
ChEMBL 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F 10.1021/jm7011722
5311258 9194 44 None 14 4 Human 8.8 pKi = 8.8 Binding
Binding affinity at human 5HT1F receptorBinding affinity at human 5HT1F receptor
ChEMBL 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F 10.1021/jm7011722
CHEMBL101690 9194 44 None 14 4 Human 8.8 pKi = 8.8 Binding
Binding affinity at human 5HT1F receptorBinding affinity at human 5HT1F receptor
ChEMBL 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F 10.1021/jm7011722
44352320 25716 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity towards human 5-hydroxytryptamine 1F receptorBinding affinity towards human 5-hydroxytryptamine 1F receptor
ChEMBL 351 3 2 2 4.4 CN1CCC(c2c[nH]c3cccc(NC(=O)c4ccc(F)cc4)c23)CC1 10.1021/jm0155190
CHEMBL128636 25716 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity towards human 5-hydroxytryptamine 1F receptorBinding affinity towards human 5-hydroxytryptamine 1F receptor
ChEMBL 351 3 2 2 4.4 CN1CCC(c2c[nH]c3cccc(NC(=O)c4ccc(F)cc4)c23)CC1 10.1021/jm0155190
151 9194 44 None 14 4 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F 10.1016/j.bmcl.2003.09.091
20 9194 44 None 14 4 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F 10.1016/j.bmcl.2003.09.091
5311258 9194 44 None 14 4 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F 10.1016/j.bmcl.2003.09.091
CHEMBL101690 9194 44 None 14 4 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F 10.1016/j.bmcl.2003.09.091
10220230 114199 2 None 4 3 Human 7.0 pKi = 7 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 230 1 2 3 2.0 CN1CCC(c2c[nH]c3ccc(N)nc23)CC1 10.1021/jm030020m
CHEMBL318105 114199 2 None 4 3 Human 7.0 pKi = 7 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 230 1 2 3 2.0 CN1CCC(c2c[nH]c3ccc(N)nc23)CC1 10.1021/jm030020m
10220244 114201 1 None - 1 Human 7.0 pKi = 7 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 231 1 2 3 2.1 CN1CCC(c2c[nH]c3ccc(O)nc23)CC1 10.1021/jm030020m
CHEMBL318110 114201 1 None - 1 Human 7.0 pKi = 7 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 231 1 2 3 2.1 CN1CCC(c2c[nH]c3ccc(O)nc23)CC1 10.1021/jm030020m
24865727 199892 0 None -630 11 Human 6.0 pKi = 6 Binding
Displacement of radioligand from human cloned 5HT1F receptorDisplacement of radioligand from human cloned 5HT1F receptor
ChEMBL 479 7 0 5 4.4 Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCS5(=O)=O)c4)CC3)cccc2n1 10.1021/jm8001444
CHEMBL522708 199892 0 None -630 11 Human 6.0 pKi = 6 Binding
Displacement of radioligand from human cloned 5HT1F receptorDisplacement of radioligand from human cloned 5HT1F receptor
ChEMBL 479 7 0 5 4.4 Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCS5(=O)=O)c4)CC3)cccc2n1 10.1021/jm8001444
11810310 11490 0 None 12 4 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 352 3 2 3 3.8 CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccc(F)c4)nc23)CC1 10.1021/jm030020m
CHEMBL103550 11490 0 None 12 4 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 352 3 2 3 3.8 CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccc(F)c4)nc23)CC1 10.1021/jm030020m
10970604 11835 0 None -3 3 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 367 3 3 3 4.2 CN1CCC(c2c[nH]c3ccc(NC(=O)Nc4ccc(F)cc4)nc23)CC1 10.1021/jm030020m
CHEMBL105369 11835 0 None -3 3 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 367 3 3 3 4.2 CN1CCC(c2c[nH]c3ccc(NC(=O)Nc4ccc(F)cc4)nc23)CC1 10.1021/jm030020m
11727140 116170 0 None 58 4 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 326 3 2 3 3.5 CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCCC4)nc23)CC1 10.1021/jm030020m
CHEMBL321967 116170 0 None 58 4 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 326 3 2 3 3.5 CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCCC4)nc23)CC1 10.1021/jm030020m
10915350 170185 0 None 9 3 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 359 3 2 4 3.5 CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccc(C#N)c4)nc23)CC1 10.1021/jm030020m
CHEMBL419547 170185 0 None 9 3 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 359 3 2 4 3.5 CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccc(C#N)c4)nc23)CC1 10.1021/jm030020m
122190357 130255 0 None - 1 Human 6.0 pKi = 6.0 Binding
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
ChEMBL 356 4 2 4 3.3 CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2O)CC1 10.1016/j.bmcl.2015.07.042
CHEMBL3617556 130255 0 None - 1 Human 6.0 pKi = 6.0 Binding
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
ChEMBL 356 4 2 4 3.3 CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2O)CC1 10.1016/j.bmcl.2015.07.042
44395894 73722 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 371 3 1 4 4.2 CN1CCC(c2noc3ccc(NC(=O)c4ccc(F)cc4F)cc23)CC1 10.1016/j.bmcl.2004.09.079
CHEMBL186662 73722 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 371 3 1 4 4.2 CN1CCC(c2noc3ccc(NC(=O)c4ccc(F)cc4F)cc23)CC1 10.1016/j.bmcl.2004.09.079
11035452 11776 0 None 8 4 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 348 3 2 3 3.9 Cc1ccccc1C(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
CHEMBL105025 11776 0 None 8 4 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 348 3 2 3 3.9 Cc1ccccc1C(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
11068036 170267 0 None 2 2 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 348 3 2 3 3.9 Cc1ccc(C(=O)Nc2ccc3[nH]cc(C4CCN(C)CC4)c3n2)cc1 10.1021/jm030020m
CHEMBL420101 170267 0 None 2 2 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 348 3 2 3 3.9 Cc1ccc(C(=O)Nc2ccc3[nH]cc(C4CCN(C)CC4)c3n2)cc1 10.1021/jm030020m
11223004 208993 0 None -4 5 Human 7.9 pKi = 7.9 Binding
Inhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cellsInhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cells
ChEMBL 389 5 3 3 3.9 O=S(=O)(Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1)c1ccccc1Cl 10.1021/jm049243i
CHEMBL609742 208993 0 None -4 5 Human 7.9 pKi = 7.9 Binding
Inhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cellsInhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cells
ChEMBL 389 5 3 3 3.9 O=S(=O)(Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1)c1ccccc1Cl 10.1021/jm049243i
44395930 73783 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 388 3 2 4 4.0 CN1CCC(N2CNc3ccc(NC(=O)c4ccc(F)cc4Cl)cc32)CC1 10.1016/j.bmcl.2004.09.079
CHEMBL186951 73783 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 388 3 2 4 4.0 CN1CCC(N2CNc3ccc(NC(=O)c4ccc(F)cc4Cl)cc32)CC1 10.1016/j.bmcl.2004.09.079
10991087 11310 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 328 6 2 3 3.9 CCCCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
CHEMBL102344 11310 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 328 6 2 3 3.9 CCCCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
10904295 11481 0 None 1 4 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 352 3 2 3 3.8 CN1CCC(c2c[nH]c3cnc(NC(=O)c4ccc(F)cc4)cc23)CC1 10.1021/jm030020m
CHEMBL103503 11481 0 None 1 4 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 352 3 2 3 3.8 CN1CCC(c2c[nH]c3cnc(NC(=O)c4ccc(F)cc4)cc23)CC1 10.1021/jm030020m
10925382 11788 0 None 43 4 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 324 3 2 4 3.2 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccco4)nc23)CC1 10.1021/jm030020m
CHEMBL105091 11788 0 None 43 4 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 324 3 2 4 3.2 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccco4)nc23)CC1 10.1021/jm030020m
10991464 138599 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 341 5 1 4 3.6 Cc1oc2ccc(NC(=O)c3ccc(F)cc3)nc2c1CCN(C)C 10.1016/j.bmcl.2003.09.091
CHEMBL369391 138599 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 341 5 1 4 3.6 Cc1oc2ccc(NC(=O)c3ccc(F)cc3)nc2c1CCN(C)C 10.1016/j.bmcl.2003.09.091
122190351 130250 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
ChEMBL 358 4 1 3 3.7 CN1CCC(C(=O)c2cc(NC(=O)c3ccc(F)cc3)ccc2F)CC1 10.1016/j.bmcl.2015.07.042
CHEMBL3617551 130250 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
ChEMBL 358 4 1 3 3.7 CN1CCC(C(=O)c2cc(NC(=O)c3ccc(F)cc3)ccc2F)CC1 10.1016/j.bmcl.2015.07.042
11069268 11927 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 394 6 2 3 4.9 CCCCN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 10.1021/jm030020m
CHEMBL105850 11927 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 394 6 2 3 4.9 CCCCN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 10.1021/jm030020m
10925076 115179 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 314 5 2 3 3.5 CCCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
CHEMBL319857 115179 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 314 5 2 3 3.5 CCCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
11068509 115712 0 None 6 2 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 364 4 2 4 3.6 COc1cccc(C(=O)Nc2ccc3[nH]cc(C4CCN(C)CC4)c3n2)c1 10.1021/jm030020m
CHEMBL321133 115712 0 None 6 2 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 364 4 2 4 3.6 COc1cccc(C(=O)Nc2ccc3[nH]cc(C4CCN(C)CC4)c3n2)c1 10.1021/jm030020m
11200511 208509 0 None -15 8 Human 7.8 pKi = 7.8 Binding
Inhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cellsInhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cells
ChEMBL 403 5 2 3 4.3 CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3ccccc3Cl)cc12 10.1021/jm049243i
CHEMBL606547 208509 0 None -15 8 Human 7.8 pKi = 7.8 Binding
Inhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cellsInhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cells
ChEMBL 403 5 2 3 4.3 CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3ccccc3Cl)cc12 10.1021/jm049243i
44395925 73921 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 390 3 2 4 3.6 CN1CCC(N2CNc3ccc(NC(=O)c4c(F)cc(F)cc4F)cc32)CC1 10.1016/j.bmcl.2004.09.079
CHEMBL187581 73921 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 390 3 2 4 3.6 CN1CCC(N2CNc3ccc(NC(=O)c4c(F)cc(F)cc4F)cc32)CC1 10.1016/j.bmcl.2004.09.079
44395786 177785 0 None 9 2 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 353 3 1 4 4.0 CN1CCC(c2noc3ccc(NC(=O)c4ccc(F)cc4)cc23)CC1 10.1016/j.bmcl.2004.09.079
CHEMBL445651 177785 0 None 9 2 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 353 3 1 4 4.0 CN1CCC(c2noc3ccc(NC(=O)c4ccc(F)cc4)cc23)CC1 10.1016/j.bmcl.2004.09.079
71459954 85957 0 None -17 7 Human 7.8 pKi = 7.8 Binding
Inhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cellsInhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cells
ChEMBL 495 6 3 3 4.0 O=S(=O)(Cc1ccccc1I)Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1 10.1021/jm049243i
CHEMBL2113386 85957 0 None -17 7 Human 7.8 pKi = 7.8 Binding
Inhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cellsInhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cells
ChEMBL 495 6 3 3 4.0 O=S(=O)(Cc1ccccc1I)Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1 10.1021/jm049243i
11122117 11758 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 366 4 2 3 4.2 CCN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 10.1021/jm030020m
CHEMBL104953 11758 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 366 4 2 3 4.2 CCN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 10.1021/jm030020m
122190354 130253 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
ChEMBL 374 4 1 3 4.3 CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2Cl)CC1 10.1016/j.bmcl.2015.07.042
CHEMBL3617554 130253 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
ChEMBL 374 4 1 3 4.3 CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2Cl)CC1 10.1016/j.bmcl.2015.07.042
10959868 11851 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 380 5 2 3 4.5 CCCN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 10.1021/jm030020m
CHEMBL105478 11851 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 380 5 2 3 4.5 CCCN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 10.1021/jm030020m
11121708 11646 0 None 2 2 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 352 3 2 3 3.8 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccc4F)nc23)CC1 10.1021/jm030020m
CHEMBL104384 11646 0 None 2 2 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 352 3 2 3 3.8 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccc4F)nc23)CC1 10.1021/jm030020m
11822996 11831 0 None 19 3 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 308 3 2 4 1.7 CN1CCC(c2c[nH]c3ccc(NS(C)(=O)=O)nc23)CC1 10.1021/jm030020m
CHEMBL105327 11831 0 None 19 3 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 308 3 2 4 1.7 CN1CCC(c2c[nH]c3ccc(NS(C)(=O)=O)nc23)CC1 10.1021/jm030020m
11003379 115878 0 None 3 3 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 379 4 2 5 3.5 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccc4[N+](=O)[O-])nc23)CC1 10.1021/jm030020m
CHEMBL321343 115878 0 None 3 3 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 379 4 2 5 3.5 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccc4[N+](=O)[O-])nc23)CC1 10.1021/jm030020m
9935387 106218 0 None -251 14 Human 6.7 pKi = 6.7 Binding
The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1F receptor in CHO cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1F receptor in CHO cells, using [3H]5-HT as radioligand
ChEMBL 491 5 1 6 5.0 COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1 10.1016/s0960-894x(02)00172-5
CHEMBL282971 106218 0 None -251 14 Human 6.7 pKi = 6.7 Binding
The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1F receptor in CHO cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1F receptor in CHO cells, using [3H]5-HT as radioligand
ChEMBL 491 5 1 6 5.0 COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1 10.1016/s0960-894x(02)00172-5
10287730 10309 40 None -2511 12 Human 5.7 pKi = 5.7 Binding
Binding affinity for human 5-hydroxytryptamine 1F receptor Binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 412 6 0 5 4.3 Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2 10.1021/jm049039v
77 10309 40 None -2511 12 Human 5.7 pKi = 5.7 Binding
Binding affinity for human 5-hydroxytryptamine 1F receptor Binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 412 6 0 5 4.3 Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2 10.1021/jm049039v
CHEMBL425190 10309 40 None -2511 12 Human 5.7 pKi = 5.7 Binding
Binding affinity for human 5-hydroxytryptamine 1F receptor Binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 412 6 0 5 4.3 Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2 10.1021/jm049039v
151 9194 44 None 14 4 Human 8.7 pKi = 8.7 Binding
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
ChEMBL 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F 10.1016/j.bmcl.2015.07.042
20 9194 44 None 14 4 Human 8.7 pKi = 8.7 Binding
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
ChEMBL 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F 10.1016/j.bmcl.2015.07.042
5311258 9194 44 None 14 4 Human 8.7 pKi = 8.7 Binding
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
ChEMBL 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F 10.1016/j.bmcl.2015.07.042
CHEMBL101690 9194 44 None 14 4 Human 8.7 pKi = 8.7 Binding
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
ChEMBL 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F 10.1016/j.bmcl.2015.07.042
151 9194 44 None 14 4 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F 10.1016/j.bmcl.2004.09.079
20 9194 44 None 14 4 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F 10.1016/j.bmcl.2004.09.079
5311258 9194 44 None 14 4 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F 10.1016/j.bmcl.2004.09.079
CHEMBL101690 9194 44 None 14 4 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F 10.1016/j.bmcl.2004.09.079
151 9194 44 None 14 4 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F 10.1021/jm030020m
20 9194 44 None 14 4 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F 10.1021/jm030020m
5311258 9194 44 None 14 4 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F 10.1021/jm030020m
CHEMBL101690 9194 44 None 14 4 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F 10.1021/jm030020m
44395832 129972 5 None 5 4 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 351 3 1 3 4.3 CN1CCC(n2ccc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 10.1016/j.bmcl.2004.09.079
CHEMBL361303 129972 5 None 5 4 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 351 3 1 3 4.3 CN1CCC(n2ccc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 10.1016/j.bmcl.2004.09.079
11610526 9062 64 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human 5-HT1F assessed as inhibition constant incubated for 10 mins by radioligand binding assayBinding affinity to human 5-HT1F assessed as inhibition constant incubated for 10 mins by radioligand binding assay
ChEMBL 377 4 1 4 3.3 CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F 10.1021/acs.jmedchem.2c00633
3928 9062 64 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human 5-HT1F assessed as inhibition constant incubated for 10 mins by radioligand binding assayBinding affinity to human 5-HT1F assessed as inhibition constant incubated for 10 mins by radioligand binding assay
ChEMBL 377 4 1 4 3.3 CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F 10.1021/acs.jmedchem.2c00633
5351 9062 64 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human 5-HT1F assessed as inhibition constant incubated for 10 mins by radioligand binding assayBinding affinity to human 5-HT1F assessed as inhibition constant incubated for 10 mins by radioligand binding assay
ChEMBL 377 4 1 4 3.3 CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F 10.1021/acs.jmedchem.2c00633
CHEMBL3039520 9062 64 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human 5-HT1F assessed as inhibition constant incubated for 10 mins by radioligand binding assayBinding affinity to human 5-HT1F assessed as inhibition constant incubated for 10 mins by radioligand binding assay
ChEMBL 377 4 1 4 3.3 CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F 10.1021/acs.jmedchem.2c00633
DB11732 9062 64 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to human 5-HT1F assessed as inhibition constant incubated for 10 mins by radioligand binding assayBinding affinity to human 5-HT1F assessed as inhibition constant incubated for 10 mins by radioligand binding assay
ChEMBL 377 4 1 4 3.3 CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F 10.1021/acs.jmedchem.2c00633
10000386 66893 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 389 3 1 4 4.3 CN1CCC(c2coc3ccc(NC(=O)c4c(F)cc(F)cc4F)nc23)CC1 10.1016/j.bmcl.2003.09.091
CHEMBL173949 66893 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 389 3 1 4 4.3 CN1CCC(c2coc3ccc(NC(=O)c4c(F)cc(F)cc4F)nc23)CC1 10.1016/j.bmcl.2003.09.091
11098166 116564 0 None 3 3 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 287 2 3 3 2.1 CNC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
CHEMBL323264 116564 0 None 3 3 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 287 2 3 3 2.1 CNC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
11384146 208512 0 None -6 9 Human 8.6 pKi = 8.6 Binding
Inhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cellsInhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cells
ChEMBL 403 5 2 3 4.3 CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3cccc(Cl)c3)cc12 10.1021/jm049243i
CHEMBL606556 208512 0 None -6 9 Human 8.6 pKi = 8.6 Binding
Inhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cellsInhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cells
ChEMBL 403 5 2 3 4.3 CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3cccc(Cl)c3)cc12 10.1021/jm049243i
44386896 139063 0 None - 1 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 387 3 1 4 4.7 CN1CCC(c2coc3ccc(NC(=O)c4c(F)cccc4Cl)nc23)CC1 10.1016/j.bmcl.2003.09.091
CHEMBL369705 139063 0 None - 1 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 387 3 1 4 4.7 CN1CCC(c2coc3ccc(NC(=O)c4c(F)cccc4Cl)nc23)CC1 10.1016/j.bmcl.2003.09.091
11728004 11225 0 None 1 3 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 356 8 2 3 4.7 CCCCCCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
CHEMBL101686 11225 0 None 1 3 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 356 8 2 3 4.7 CCCCCCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
11111280 115975 0 None -1 3 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 364 4 2 4 3.6 COc1ccccc1C(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
CHEMBL321562 115975 0 None -1 3 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 364 4 2 4 3.6 COc1ccccc1C(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
11824009 170079 0 None 33 2 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 340 3 2 3 3.9 CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCCCC4)nc23)CC1 10.1021/jm030020m
CHEMBL418806 170079 0 None 33 2 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 340 3 2 3 3.9 CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCCCC4)nc23)CC1 10.1021/jm030020m
11747350 114109 0 None -100 10 Human 5.7 pKi = 5.7 Binding
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligandBinding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligand
ChEMBL 260 5 1 3 2.4 CCOC(=O)c1[nH]c2ccccc2c1CCN(C)C 10.1021/jm010943m
CHEMBL317535 114109 0 None -100 10 Human 5.7 pKi = 5.7 Binding
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligandBinding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligand
ChEMBL 260 5 1 3 2.4 CCOC(=O)c1[nH]c2ccccc2c1CCN(C)C 10.1021/jm010943m
10880608 11419 0 None - 1 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 284 3 2 3 2.6 CCN1CC=C(c2c[nH]c3ccc(NC(C)=O)nc23)CC1 10.1021/jm030020m
CHEMBL103058 11419 0 None - 1 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 284 3 2 3 2.6 CCN1CC=C(c2c[nH]c3ccc(NC(C)=O)nc23)CC1 10.1021/jm030020m
11043914 11552 0 None -104 3 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 272 2 2 3 2.3 CC(=O)Nc1cc2c(C3CCN(C)CC3)c[nH]c2cn1 10.1021/jm030020m
CHEMBL104026 11552 0 None -104 3 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 272 2 2 3 2.3 CC(=O)Nc1cc2c(C3CCN(C)CC3)c[nH]c2cn1 10.1021/jm030020m
10891048 11583 0 None 2 4 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 273 2 2 4 1.7 CC(=O)Nc1ncc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
CHEMBL104158 11583 0 None 2 4 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 273 2 2 4 1.7 CC(=O)Nc1ncc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
10198756 11642 1 None -1 3 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 245 2 1 3 2.4 COc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
CHEMBL104374 11642 1 None -1 3 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 245 2 1 3 2.4 COc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
122190360 130259 0 None - 1 Human 5.6 pKi = 5.6 Binding
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
ChEMBL 341 4 1 4 3.0 CN1CCC(C(=O)c2ccnc(NC(=O)c3ccc(F)cc3)c2)CC1 10.1016/j.bmcl.2015.07.042
CHEMBL3617560 130259 0 None - 1 Human 5.6 pKi = 5.6 Binding
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
ChEMBL 341 4 1 4 3.0 CN1CCC(C(=O)c2ccnc(NC(=O)c3ccc(F)cc3)c2)CC1 10.1016/j.bmcl.2015.07.042
11013959 114047 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 364 4 2 3 4.1 CCN1CC=C(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 10.1021/jm030020m
CHEMBL316979 114047 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 364 4 2 3 4.1 CCN1CC=C(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 10.1021/jm030020m
2543 10479 68 None -5 32 Human 7.6 pKi = 7.6 Binding
Binding affinity towards human 5-hydroxytryptamine 1F receptor was determinedBinding affinity towards human 5-hydroxytryptamine 1F receptor was determined
ChEMBL 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1021/jm0155190
5358 10479 68 None -5 32 Human 7.6 pKi = 7.6 Binding
Binding affinity towards human 5-hydroxytryptamine 1F receptor was determinedBinding affinity towards human 5-hydroxytryptamine 1F receptor was determined
ChEMBL 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1021/jm0155190
54 10479 68 None -5 32 Human 7.6 pKi = 7.6 Binding
Binding affinity towards human 5-hydroxytryptamine 1F receptor was determinedBinding affinity towards human 5-hydroxytryptamine 1F receptor was determined
ChEMBL 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1021/jm0155190
CHEMBL128 10479 68 None -5 32 Human 7.6 pKi = 7.6 Binding
Binding affinity towards human 5-hydroxytryptamine 1F receptor was determinedBinding affinity towards human 5-hydroxytryptamine 1F receptor was determined
ChEMBL 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1021/jm0155190
DB00669 10479 68 None -5 32 Human 7.6 pKi = 7.6 Binding
Binding affinity towards human 5-hydroxytryptamine 1F receptor was determinedBinding affinity towards human 5-hydroxytryptamine 1F receptor was determined
ChEMBL 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1021/jm0155190
6918542 211703 24 None -1258 10 Human 5.6 pKi = 5.6 Binding
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligandBinding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligand
ChEMBL 358 6 0 5 3.0 COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1 10.1021/jm010943m
CHEMBL76237 211703 24 None -1258 10 Human 5.6 pKi = 5.6 Binding
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligandBinding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligand
ChEMBL 358 6 0 5 3.0 COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1 10.1021/jm010943m
6918648 108336 1 None -407 14 Human 6.6 pKi = 6.6 Binding
Compound was tested for its binding affinity against 5-hydroxytryptamine 1F receptor in human cloned receptors in CHO cells using [3H]5-HTCompound was tested for its binding affinity against 5-hydroxytryptamine 1F receptor in human cloned receptors in CHO cells using [3H]5-HT
ChEMBL 465 5 1 6 4.4 COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 10.1021/jm980532e
CHEMBL29846 108336 1 None -407 14 Human 6.6 pKi = 6.6 Binding
Compound was tested for its binding affinity against 5-hydroxytryptamine 1F receptor in human cloned receptors in CHO cells using [3H]5-HTCompound was tested for its binding affinity against 5-hydroxytryptamine 1F receptor in human cloned receptors in CHO cells using [3H]5-HT
ChEMBL 465 5 1 6 4.4 COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 10.1021/jm980532e
6918648 108336 1 None -407 14 Human 6.6 pKi = 6.6 Binding
The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1F receptor in CHO cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1F receptor in CHO cells, using [3H]5-HT as radioligand
ChEMBL 465 5 1 6 4.4 COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 10.1016/s0960-894x(02)00172-5
CHEMBL29846 108336 1 None -407 14 Human 6.6 pKi = 6.6 Binding
The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1F receptor in CHO cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1F receptor in CHO cells, using [3H]5-HT as radioligand
ChEMBL 465 5 1 6 4.4 COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 10.1016/s0960-894x(02)00172-5
11760896 11762 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 388 4 2 4 3.3 CN1CCC(c2c[nH]c3ccc(NS(=O)(=O)c4ccc(F)cc4)nc23)CC1 10.1021/jm030020m
CHEMBL104968 11762 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 388 4 2 4 3.3 CN1CCC(c2c[nH]c3ccc(NS(=O)(=O)c4ccc(F)cc4)nc23)CC1 10.1021/jm030020m
9796627 103428 0 None 1 7 Human 7.5 pKi = 7.5 Binding
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO using [3H]5-HT radioligandBinding affinity against 5-hydroxytryptamine 1F receptor in CHO using [3H]5-HT radioligand
ChEMBL 308 4 1 4 3.1 CN(C)CCc1cn(C(=O)c2ccccc2)c2ccc(O)cc12 10.1021/jm010943m
CHEMBL263700 103428 0 None 1 7 Human 7.5 pKi = 7.5 Binding
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO using [3H]5-HT radioligandBinding affinity against 5-hydroxytryptamine 1F receptor in CHO using [3H]5-HT radioligand
ChEMBL 308 4 1 4 3.1 CN(C)CCc1cn(C(=O)c2ccccc2)c2ccc(O)cc12 10.1021/jm010943m
44387174 68547 0 None - 1 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 387 3 1 4 4.7 CN1CCC(c2coc3ccc(NC(=O)c4ccc(F)cc4Cl)nc23)CC1 10.1016/j.bmcl.2003.09.091
CHEMBL177238 68547 0 None - 1 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 387 3 1 4 4.7 CN1CCC(c2coc3ccc(NC(=O)c4ccc(F)cc4Cl)nc23)CC1 10.1016/j.bmcl.2003.09.091
9863365 68549 0 None - 1 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 353 3 1 4 4.0 CN1CCC(c2coc3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 10.1016/j.bmcl.2003.09.091
CHEMBL177258 68549 0 None - 1 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 353 3 1 4 4.0 CN1CCC(c2coc3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 10.1016/j.bmcl.2003.09.091
10436045 10289 4 None 1 13 Human 8.5 pKi = 8.5 Binding
Binding affinity for 5-hydroxytryptamine 1F receptor was determinedBinding affinity for 5-hydroxytryptamine 1F receptor was determined
ChEMBL 499 9 3 3 6.4 O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 10.1016/s0960-894x(01)00397-3
782 10289 4 None 1 13 Human 8.5 pKi = 8.5 Binding
Binding affinity for 5-hydroxytryptamine 1F receptor was determinedBinding affinity for 5-hydroxytryptamine 1F receptor was determined
ChEMBL 499 9 3 3 6.4 O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 10.1016/s0960-894x(01)00397-3
CHEMBL432713 10289 4 None 1 13 Human 8.5 pKi = 8.5 Binding
Binding affinity for 5-hydroxytryptamine 1F receptor was determinedBinding affinity for 5-hydroxytryptamine 1F receptor was determined
ChEMBL 499 9 3 3 6.4 O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 10.1016/s0960-894x(01)00397-3
11372635 73861 0 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 387 3 1 4 4.7 CN1CCC(c2noc3ccc(NC(=O)c4ccc(F)cc4Cl)cc23)CC1 10.1016/j.bmcl.2004.09.079
CHEMBL187308 73861 0 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 387 3 1 4 4.7 CN1CCC(c2noc3ccc(NC(=O)c4ccc(F)cc4Cl)cc23)CC1 10.1016/j.bmcl.2004.09.079
44352344 171149 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity towards human 5-hydroxytryptamine 1F receptorBinding affinity towards human 5-hydroxytryptamine 1F receptor
ChEMBL 325 5 2 2 3.7 CN(C)CCc1c[nH]c2cccc(NC(=O)c3ccc(F)cc3)c12 10.1021/jm0155190
CHEMBL421287 171149 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity towards human 5-hydroxytryptamine 1F receptorBinding affinity towards human 5-hydroxytryptamine 1F receptor
ChEMBL 325 5 2 2 3.7 CN(C)CCc1c[nH]c2cccc(NC(=O)c3ccc(F)cc3)c12 10.1021/jm0155190
11808793 11301 0 None 10 2 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 301 3 3 3 2.5 CCNC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
CHEMBL102292 11301 0 None 10 2 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 301 3 3 3 2.5 CCNC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
9862256 213899 0 None -2 9 Human 8.4 pKi = 8.4 Binding
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligandBinding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligand
ChEMBL 328 5 0 4 3.0 CN(C)CCc1cccc2c1ccn2S(=O)(=O)c1ccccc1 10.1021/jm010943m
CHEMBL92139 213899 0 None -2 9 Human 8.4 pKi = 8.4 Binding
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligandBinding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligand
ChEMBL 328 5 0 4 3.0 CN(C)CCc1cccc2c1ccn2S(=O)(=O)c1ccccc1 10.1021/jm010943m
9950390 73025 0 None 223 4 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 352 3 2 3 3.8 CN1CCC(c2n[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc23)CC1 10.1016/j.bmcl.2004.09.079
CHEMBL184597 73025 0 None 223 4 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 352 3 2 3 3.8 CN1CCC(c2n[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc23)CC1 10.1016/j.bmcl.2004.09.079
10861816 11817 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 380 4 2 3 4.5 CC(C)N1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 10.1021/jm030020m
CHEMBL105240 11817 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 380 4 2 3 4.5 CC(C)N1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 10.1021/jm030020m
6918647 107522 2 None -63 14 Human 6.5 pKi = 6.5 Binding
Compound was tested for its binding affinity against 5-hydroxytryptamine 1F receptor in human cloned receptors in CHO cells using [3H]5-HTCompound was tested for its binding affinity against 5-hydroxytryptamine 1F receptor in human cloned receptors in CHO cells using [3H]5-HT
ChEMBL 439 5 1 5 3.0 COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1 10.1021/jm980532e
CHEMBL292759 107522 2 None -63 14 Human 6.5 pKi = 6.5 Binding
Compound was tested for its binding affinity against 5-hydroxytryptamine 1F receptor in human cloned receptors in CHO cells using [3H]5-HTCompound was tested for its binding affinity against 5-hydroxytryptamine 1F receptor in human cloned receptors in CHO cells using [3H]5-HT
ChEMBL 439 5 1 5 3.0 COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1 10.1021/jm980532e
9913554 107769 0 None -398 14 Human 6.5 pKi = 6.5 Binding
The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1F receptor in CHO cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1F receptor in CHO cells, using [3H]5-HT as radioligand
ChEMBL 491 5 1 6 5.0 COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1 10.1016/s0960-894x(02)00172-5
CHEMBL29433 107769 0 None -398 14 Human 6.5 pKi = 6.5 Binding
The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1F receptor in CHO cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1F receptor in CHO cells, using [3H]5-HT as radioligand
ChEMBL 491 5 1 6 5.0 COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1 10.1016/s0960-894x(02)00172-5
122190359 130257 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
ChEMBL 341 4 1 4 3.0 CN1CCC(C(=O)c2cncc(NC(=O)c3ccc(F)cc3)c2)CC1 10.1016/j.bmcl.2015.07.042
CHEMBL3617559 130257 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
ChEMBL 341 4 1 4 3.0 CN1CCC(C(=O)c2cncc(NC(=O)c3ccc(F)cc3)c2)CC1 10.1016/j.bmcl.2015.07.042
10527469 163044 3 None -7244 16 Rat 5.5 pKi = 5.5 Binding
Binding affinity against 5-hydroxytryptamine 1 receptor using [3H]5-HT as radioligandBinding affinity against 5-hydroxytryptamine 1 receptor using [3H]5-HT as radioligand
ChEMBL 448 4 1 7 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21 10.1021/jm970364a
CHEMBL40650 163044 3 None -7244 16 Rat 5.5 pKi = 5.5 Binding
Binding affinity against 5-hydroxytryptamine 1 receptor using [3H]5-HT as radioligandBinding affinity against 5-hydroxytryptamine 1 receptor using [3H]5-HT as radioligand
ChEMBL 448 4 1 7 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21 10.1021/jm970364a
10945589 11755 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 272 3 3 3 2.4 CCC(=O)Nc1ccc2[nH]cc(C3CCNCC3)c2n1 10.1021/jm030020m
CHEMBL104946 11755 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 272 3 3 3 2.4 CCC(=O)Nc1ccc2[nH]cc(C3CCNCC3)c2n1 10.1021/jm030020m
44395787 133561 7 None 75 3 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 352 3 1 4 3.7 CN1CCC(n2ncc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 10.1016/j.bmcl.2004.09.079
CHEMBL365405 133561 7 None 75 3 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 352 3 1 4 3.7 CN1CCC(n2ncc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 10.1016/j.bmcl.2004.09.079
10971452 11665 0 None 1 3 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 402 3 2 3 4.9 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(Cl)cc4Cl)nc23)CC1 10.1021/jm030020m
CHEMBL104496 11665 0 None 1 3 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 402 3 2 3 4.9 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(Cl)cc4Cl)nc23)CC1 10.1021/jm030020m
11120893 11294 0 None 181 4 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 324 3 2 4 3.2 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccoc4)nc23)CC1 10.1021/jm030020m
CHEMBL102250 11294 0 None 181 4 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 324 3 2 4 3.2 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccoc4)nc23)CC1 10.1021/jm030020m
11809037 11865 0 None 1 3 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 309 3 1 5 1.7 CN1CCC(c2c[nH]c3ccc(OS(C)(=O)=O)nc23)CC1 10.1021/jm030020m
CHEMBL105556 11865 0 None 1 3 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 309 3 1 5 1.7 CN1CCC(c2c[nH]c3ccc(OS(C)(=O)=O)nc23)CC1 10.1021/jm030020m
44395809 129882 0 None 2 4 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 353 3 1 3 3.5 CN1CCC(N2CCc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 10.1016/j.bmcl.2004.09.079
CHEMBL361061 129882 0 None 2 4 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 353 3 1 3 3.5 CN1CCC(N2CCc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 10.1016/j.bmcl.2004.09.079
122190352 130251 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
ChEMBL 358 4 1 3 3.7 CN1CCC(C(=O)c2cc(F)cc(NC(=O)c3ccc(F)cc3)c2)CC1 10.1016/j.bmcl.2015.07.042
CHEMBL3617552 130251 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
ChEMBL 358 4 1 3 3.7 CN1CCC(C(=O)c2cc(F)cc(NC(=O)c3ccc(F)cc3)c2)CC1 10.1016/j.bmcl.2015.07.042
11047115 11792 0 None 3 4 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 379 4 2 5 3.5 CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccc([N+](=O)[O-])c4)nc23)CC1 10.1021/jm030020m
CHEMBL105118 11792 0 None 3 4 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 379 4 2 5 3.5 CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccc([N+](=O)[O-])c4)nc23)CC1 10.1021/jm030020m
10934159 116218 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 258 2 3 3 2.0 CC(=O)Nc1ccc2[nH]cc(C3CCNCC3)c2n1 10.1021/jm030020m
CHEMBL322018 116218 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 258 2 3 3 2.0 CC(=O)Nc1ccc2[nH]cc(C3CCNCC3)c2n1 10.1021/jm030020m
9817810 24144 1 None -19 8 Human 7.3 pKi = 7.3 Binding
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligandBinding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligand
ChEMBL 300 4 1 4 2.4 NCCc1cccc2c1ccn2S(=O)(=O)c1ccccc1 10.1021/jm010943m
CHEMBL125745 24144 1 None -19 8 Human 7.3 pKi = 7.3 Binding
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligandBinding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligand
ChEMBL 300 4 1 4 2.4 NCCc1cccc2c1ccn2S(=O)(=O)c1ccccc1 10.1021/jm010943m
10445946 174642 4 None 50 4 Human 8.3 pKi = 8.3 Binding
Binding affinity to 5-HT1F (unknown origin) assessed as inhibition constantBinding affinity to 5-HT1F (unknown origin) assessed as inhibition constant
ChEMBL 272 2 2 3 2.3 CC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/acs.jmedchem.2c00633
CHEMBL431041 174642 4 None 50 4 Human 8.3 pKi = 8.3 Binding
Binding affinity to 5-HT1F (unknown origin) assessed as inhibition constantBinding affinity to 5-HT1F (unknown origin) assessed as inhibition constant
ChEMBL 272 2 2 3 2.3 CC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/acs.jmedchem.2c00633
10445946 174642 4 None 50 4 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 272 2 2 3 2.3 CC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
CHEMBL431041 174642 4 None 50 4 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 272 2 2 3 2.3 CC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
9798021 130248 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
ChEMBL 340 4 1 3 3.6 CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2)CC1 10.1016/j.bmcl.2015.07.042
CHEMBL3617549 130248 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
ChEMBL 340 4 1 3 3.6 CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2)CC1 10.1016/j.bmcl.2015.07.042
9947817 11819 0 None 56 9 Human 8.3 pKi = 8.3 Binding
Binding affinity to 5-HT1F (unknown origin) assessed as inhibition constantBinding affinity to 5-HT1F (unknown origin) assessed as inhibition constant
ChEMBL 286 3 2 3 2.7 CCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/acs.jmedchem.2c00633
CHEMBL105261 11819 0 None 56 9 Human 8.3 pKi = 8.3 Binding
Binding affinity to 5-HT1F (unknown origin) assessed as inhibition constantBinding affinity to 5-HT1F (unknown origin) assessed as inhibition constant
ChEMBL 286 3 2 3 2.7 CCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/acs.jmedchem.2c00633
9947817 11819 0 None 56 9 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 286 3 2 3 2.7 CCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
CHEMBL105261 11819 0 None 56 9 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 286 3 2 3 2.7 CCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
10926112 179410 0 None 17 4 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 348 3 2 3 3.9 Cc1cccc(C(=O)Nc2ccc3[nH]cc(C4CCN(C)CC4)c3n2)c1 10.1021/jm030020m
CHEMBL449406 179410 0 None 17 4 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 348 3 2 3 3.9 Cc1cccc(C(=O)Nc2ccc3[nH]cc(C4CCN(C)CC4)c3n2)c1 10.1021/jm030020m
24865725 194863 0 None -1000 12 Human 6.3 pKi = 6.3 Binding
Displacement of radioligand from human cloned 5HT1F receptorDisplacement of radioligand from human cloned 5HT1F receptor
ChEMBL 453 8 1 5 4.2 Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 10.1021/jm8001444
CHEMBL497963 194863 0 None -1000 12 Human 6.3 pKi = 6.3 Binding
Displacement of radioligand from human cloned 5HT1F receptorDisplacement of radioligand from human cloned 5HT1F receptor
ChEMBL 453 8 1 5 4.2 Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 10.1021/jm8001444
44395810 73101 0 None 1 3 Human 6.3 pKi = 6.3 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 369 3 1 4 3.4 CN1CCC(N2CCOc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 10.1016/j.bmcl.2004.09.079
CHEMBL184994 73101 0 None 1 3 Human 6.3 pKi = 6.3 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 369 3 1 4 3.4 CN1CCC(N2CCOc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 10.1016/j.bmcl.2004.09.079
122190353 130252 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
ChEMBL 358 4 1 3 3.7 CN1CCC(C(=O)c2ccc(F)c(NC(=O)c3ccc(F)cc3)c2)CC1 10.1016/j.bmcl.2015.07.042
CHEMBL3617553 130252 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
ChEMBL 358 4 1 3 3.7 CN1CCC(C(=O)c2ccc(F)c(NC(=O)c3ccc(F)cc3)c2)CC1 10.1016/j.bmcl.2015.07.042
9867475 24785 0 None -190 9 Human 6.2 pKi = 6.2 Binding
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligandBinding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligand
ChEMBL 432 7 0 5 4.2 CN(C)CCc1cccc2c1cc(C(=O)c1ccccc1)n2S(=O)(=O)c1ccccc1 10.1021/jm010943m
CHEMBL126340 24785 0 None -190 9 Human 6.2 pKi = 6.2 Binding
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligandBinding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligand
ChEMBL 432 7 0 5 4.2 CN(C)CCc1cccc2c1cc(C(=O)c1ccccc1)n2S(=O)(=O)c1ccccc1 10.1021/jm010943m
5311097 63044 30 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity to human 5-HT1F assessed as inhibition constantBinding affinity to human 5-HT1F assessed as inhibition constant
ChEMBL 351 3 2 2 4.0 CN(C)[C@@H]1CCc2[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc3c2C1 10.1021/acs.jmedchem.2c00633
CHEMBL1628565 63044 30 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity to human 5-HT1F assessed as inhibition constantBinding affinity to human 5-HT1F assessed as inhibition constant
ChEMBL 351 3 2 2 4.0 CN(C)[C@@H]1CCc2[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc3c2C1 10.1021/acs.jmedchem.2c00633
11110452 11902 0 None 6 4 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 335 3 2 4 3.0 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccn4)nc23)CC1 10.1021/jm030020m
CHEMBL105722 11902 0 None 6 4 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 335 3 2 4 3.0 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccn4)nc23)CC1 10.1021/jm030020m
11044798 11940 0 None - 1 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 300 4 2 3 3.1 CCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
CHEMBL105955 11940 0 None - 1 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 300 4 2 3 3.1 CCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 10.1021/jm030020m
122190356 130108 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
ChEMBL 370 5 1 4 3.6 COc1c(NC(=O)c2ccc(F)cc2)cccc1C(=O)C1CCN(C)CC1 10.1016/j.bmcl.2015.07.042
CHEMBL3616488 130108 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
ChEMBL 370 5 1 4 3.6 COc1c(NC(=O)c2ccc(F)cc2)cccc1C(=O)C1CCN(C)CC1 10.1016/j.bmcl.2015.07.042
11141562 115976 0 None - 1 Human 7.2 pKi = 7.2 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 314 2 2 3 3.4 CN1CCC(c2c[nH]c3ccc(NC(=O)C(C)(C)C)nc23)CC1 10.1021/jm030020m
CHEMBL321578 115976 0 None - 1 Human 7.2 pKi = 7.2 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 314 2 2 3 3.4 CN1CCC(c2c[nH]c3ccc(NC(=O)C(C)(C)C)nc23)CC1 10.1021/jm030020m
11024618 115330 0 None 2 4 Human 7.2 pKi = 7.2 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 353 3 2 4 3.2 CN1CCC(c2c[nH]c3cnc(NC(=O)c4ccc(F)cc4)nc23)CC1 10.1021/jm030020m
CHEMBL320198 115330 0 None 2 4 Human 7.2 pKi = 7.2 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 353 3 2 4 3.2 CN1CCC(c2c[nH]c3cnc(NC(=O)c4ccc(F)cc4)nc23)CC1 10.1021/jm030020m
11056946 115670 0 None 48 4 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 340 3 2 4 3.7 CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccs4)nc23)CC1 10.1021/jm030020m
CHEMBL321080 115670 0 None 48 4 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 340 3 2 4 3.7 CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccs4)nc23)CC1 10.1021/jm030020m
11824522 11662 0 None 4 4 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 359 3 2 4 3.5 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(C#N)cc4)nc23)CC1 10.1021/jm030020m
CHEMBL104484 11662 0 None 4 4 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 359 3 2 4 3.5 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(C#N)cc4)nc23)CC1 10.1021/jm030020m
11067619 11907 0 None 10 4 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 334 3 2 3 3.6 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccc4)nc23)CC1 10.1021/jm030020m
CHEMBL105743 11907 0 None 10 4 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 334 3 2 3 3.6 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccc4)nc23)CC1 10.1021/jm030020m
11046087 11719 0 None 53 4 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 340 3 2 4 3.7 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccsc4)nc23)CC1 10.1021/jm030020m
CHEMBL104753 11719 0 None 53 4 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 340 3 2 4 3.7 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccsc4)nc23)CC1 10.1021/jm030020m
11101187 115238 0 None 3 2 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 389 4 1 5 3.3 CN1CCC(c2c[nH]c3ccc(OS(=O)(=O)c4ccc(F)cc4)nc23)CC1 10.1021/jm030020m
CHEMBL319920 115238 0 None 3 2 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 389 4 1 5 3.3 CN1CCC(c2c[nH]c3ccc(OS(=O)(=O)c4ccc(F)cc4)nc23)CC1 10.1021/jm030020m
10020895 11477 0 None 7 8 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 352 3 2 3 3.8 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 10.1016/j.bmcl.2003.09.091
CHEMBL103479 11477 0 None 7 8 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 352 3 2 3 3.8 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 10.1016/j.bmcl.2003.09.091
10020895 11477 0 None 7 8 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 352 3 2 3 3.8 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 10.1021/jm030020m
CHEMBL103479 11477 0 None 7 8 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 352 3 2 3 3.8 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 10.1021/jm030020m
10872581 11701 0 None 4 4 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 379 4 2 5 3.5 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc([N+](=O)[O-])cc4)nc23)CC1 10.1021/jm030020m
CHEMBL104692 11701 0 None 4 4 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 379 4 2 5 3.5 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc([N+](=O)[O-])cc4)nc23)CC1 10.1021/jm030020m
24893978 7797 9 None -1819 8 Human 5.1 pKi = 5.1 Binding
Binding affinity to 5HT1F receptorBinding affinity to 5HT1F receptor
ChEMBL 525 6 2 4 4.9 Brc1cc(ccc1OC1CCNCC1)CN1CC[C@@H](C1)NC(=O)c1ccc(c(c1)Cl)Cl 10.1016/j.bmcl.2008.06.019
8872 7797 9 None -1819 8 Human 5.1 pKi = 5.1 Binding
Binding affinity to 5HT1F receptorBinding affinity to 5HT1F receptor
ChEMBL 525 6 2 4 4.9 Brc1cc(ccc1OC1CCNCC1)CN1CC[C@@H](C1)NC(=O)c1ccc(c(c1)Cl)Cl 10.1016/j.bmcl.2008.06.019
CHEMBL495075 7797 9 None -1819 8 Human 5.1 pKi = 5.1 Binding
Binding affinity to 5HT1F receptorBinding affinity to 5HT1F receptor
ChEMBL 525 6 2 4 4.9 Brc1cc(ccc1OC1CCNCC1)CN1CC[C@@H](C1)NC(=O)c1ccc(c(c1)Cl)Cl 10.1016/j.bmcl.2008.06.019
10873909 11286 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 442 6 2 3 5.4 O=C(Nc1ccc2[nH]cc(C3CCN(CCc4ccccc4)CC3)c2n1)c1ccc(F)cc1 10.1021/jm030020m
CHEMBL102182 11286 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 442 6 2 3 5.4 O=C(Nc1ccc2[nH]cc(C3CCN(CCc4ccccc4)CC3)c2n1)c1ccc(F)cc1 10.1021/jm030020m
9927441 214173 0 None -229 9 Human 6.1 pKi = 6.1 Binding
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligandBinding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligand
ChEMBL 328 5 0 4 3.0 CN(C)CCc1cn(S(=O)(=O)c2ccccc2)c2ccccc12 10.1021/jm010943m
CHEMBL93868 214173 0 None -229 9 Human 6.1 pKi = 6.1 Binding
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligandBinding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligand
ChEMBL 328 5 0 4 3.0 CN(C)CCc1cn(S(=O)(=O)c2ccccc2)c2ccccc12 10.1021/jm010943m
9840850 69265 3 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to 5-HT1F (unknown origin) assessed as inhibition constantBinding affinity to 5-HT1F (unknown origin) assessed as inhibition constant
ChEMBL 339 5 2 2 4.0 Cc1[nH]c2ccc(NC(=O)c3ccc(F)cc3)cc2c1CCN(C)C 10.1021/acs.jmedchem.2c00633
CHEMBL178066 69265 3 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to 5-HT1F (unknown origin) assessed as inhibition constantBinding affinity to 5-HT1F (unknown origin) assessed as inhibition constant
ChEMBL 339 5 2 2 4.0 Cc1[nH]c2ccc(NC(=O)c3ccc(F)cc3)cc2c1CCN(C)C 10.1021/acs.jmedchem.2c00633
44352308 124265 0 None 32 12 Human 8.1 pKi = 8.1 Binding
Binding affinity towards human 5-hydroxytryptamine 1F receptor using [3H]-5-HT radioligandBinding affinity towards human 5-hydroxytryptamine 1F receptor using [3H]-5-HT radioligand
ChEMBL 339 5 2 2 4.0 Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C 10.1021/jm0155190
CHEMBL339980 124265 0 None 32 12 Human 8.1 pKi = 8.1 Binding
Binding affinity towards human 5-hydroxytryptamine 1F receptor using [3H]-5-HT radioligandBinding affinity towards human 5-hydroxytryptamine 1F receptor using [3H]-5-HT radioligand
ChEMBL 339 5 2 2 4.0 Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C 10.1021/jm0155190
9840850 69265 3 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 339 5 2 2 4.0 Cc1[nH]c2ccc(NC(=O)c3ccc(F)cc3)cc2c1CCN(C)C 10.1016/j.bmcl.2003.09.091
CHEMBL178066 69265 3 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 339 5 2 2 4.0 Cc1[nH]c2ccc(NC(=O)c3ccc(F)cc3)cc2c1CCN(C)C 10.1016/j.bmcl.2003.09.091
122190350 130249 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
ChEMBL 358 4 1 3 3.7 CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2F)CC1 10.1016/j.bmcl.2015.07.042
CHEMBL3617550 130249 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
ChEMBL 358 4 1 3 3.7 CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2F)CC1 10.1016/j.bmcl.2015.07.042
11759467 11941 0 None 4 4 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 335 3 2 4 3.0 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccncc4)nc23)CC1 10.1021/jm030020m
CHEMBL105958 11941 0 None 4 4 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 335 3 2 4 3.0 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccncc4)nc23)CC1 10.1021/jm030020m
44395762 74008 0 None 27 3 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 353 3 2 3 3.9 CN1CCC(C2CNc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 10.1016/j.bmcl.2004.09.079
CHEMBL187952 74008 0 None 27 3 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 353 3 2 3 3.9 CN1CCC(C2CNc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 10.1016/j.bmcl.2004.09.079
10946905 170461 0 None 43 4 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 312 3 2 3 3.1 CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCC4)nc23)CC1 10.1021/jm030020m
CHEMBL420475 170461 0 None 43 4 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 312 3 2 3 3.1 CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCC4)nc23)CC1 10.1021/jm030020m
122190355 130254 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
ChEMBL 354 4 1 3 3.9 Cc1c(NC(=O)c2ccc(F)cc2)cccc1C(=O)C1CCN(C)CC1 10.1016/j.bmcl.2015.07.042
CHEMBL3617555 130254 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
ChEMBL 354 4 1 3 3.9 Cc1c(NC(=O)c2ccc(F)cc2)cccc1C(=O)C1CCN(C)CC1 10.1016/j.bmcl.2015.07.042
44395762 74008 0 None 27 3 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 353 3 2 3 3.9 CN1CCC(C2CNc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 10.1016/j.bmcl.2004.09.079
CHEMBL187952 74008 0 None 27 3 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 353 3 2 3 3.9 CN1CCC(C2CNc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 10.1016/j.bmcl.2004.09.079
10308815 130256 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
ChEMBL 341 4 1 4 3.0 CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)n2)CC1 10.1016/j.bmcl.2015.07.042
CHEMBL3617557 130256 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
ChEMBL 341 4 1 4 3.0 CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)n2)CC1 10.1016/j.bmcl.2015.07.042
11099817 11309 0 None - 1 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 338 3 3 3 3.4 O=C(Nc1ccc2[nH]cc(C3CCNCC3)c2n1)c1ccc(F)cc1 10.1021/jm030020m
CHEMBL102335 11309 0 None - 1 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 338 3 3 3 3.4 O=C(Nc1ccc2[nH]cc(C3CCNCC3)c2n1)c1ccc(F)cc1 10.1021/jm030020m
44395762 74008 0 None 27 3 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 353 3 2 3 3.9 CN1CCC(C2CNc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 10.1016/j.bmcl.2004.09.079
CHEMBL187952 74008 0 None 27 3 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
ChEMBL 353 3 2 3 3.9 CN1CCC(C2CNc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 10.1016/j.bmcl.2004.09.079
22611622 11466 8 None 6 4 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 271 2 2 2 2.9 CC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2c1 10.1021/jm030020m
CHEMBL103424 11466 8 None 6 4 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 271 2 2 2 2.9 CC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2c1 10.1021/jm030020m
11011968 11713 0 None 144 4 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 298 3 2 3 2.7 CN1CCC(c2c[nH]c3ccc(NC(=O)C4CC4)nc23)CC1 10.1021/jm030020m
CHEMBL104720 11713 0 None 144 4 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
ChEMBL 298 3 2 3 2.7 CN1CCC(c2c[nH]c3ccc(NC(=O)C4CC4)nc23)CC1 10.1021/jm030020m
5 6927 72 None -144 53 Human 8.0 pKd = 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 8380639
5202 6927 72 None -144 53 Human 8.0 pKd = 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 8380639
CHEMBL39 6927 72 None -144 53 Human 8.0 pKd = 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 8380639
DB08839 6927 72 None -144 53 Human 8.0 pKd = 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 8380639
151 9194 44 None 14 4 Human 9.4 pKd = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F 15900510
20 9194 44 None 14 4 Human 9.4 pKd = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F 15900510
5311258 9194 44 None 14 4 Human 9.4 pKd = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F 15900510
CHEMBL101690 9194 44 None 14 4 Human 9.4 pKd = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F 15900510
1524 8962 96 3H-KETANSERIN -36 51 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
197 8962 96 3H-KETANSERIN -36 51 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
3822 8962 96 3H-KETANSERIN -36 51 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
88 8962 96 3H-KETANSERIN -36 51 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
CHEMBL51 8962 96 3H-KETANSERIN -36 51 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
DB12465 8962 96 3H-KETANSERIN -36 51 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
151 9194 44 UNDEFINED 14 4 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F None
20 9194 44 UNDEFINED 14 4 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F None
5311258 9194 44 UNDEFINED 14 4 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F None
CHEMBL101690 9194 44 UNDEFINED 14 4 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F None
5 6927 72 3H-5HT -144 53 Human 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5202 6927 72 3H-5HT -144 53 Human 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
CHEMBL39 6927 72 3H-5HT -144 53 Human 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
DB08839 6927 72 3H-5HT -144 53 Human 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
135 9310 43 125I-LSD -51 56 Mouse 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
1796 9310 43 125I-LSD -51 56 Mouse 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
4184 9310 43 125I-LSD -51 56 Mouse 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
CHEMBL6437 9310 43 125I-LSD -51 56 Mouse 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
DB06148 9310 43 125I-LSD -51 56 Mouse 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
4106 9280 22 125I-LSD -2511 33 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
5358812 9280 22 125I-LSD -2511 33 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
89 9280 22 125I-LSD -2511 33 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
CHEMBL93240 9280 22 125I-LSD -2511 33 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
28 10269 46 3H-5HT -602 10 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 486 9 1 7 5.2 COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C None
3292447 10269 46 3H-5HT -602 10 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 486 9 1 7 5.2 COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C None
CHEMBL20963 10269 46 3H-5HT -602 10 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 486 9 1 7 5.2 COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C None
115 10563 80 3H-5HT -24 27 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 230 1 1 2 2.1 FC(c1cccc(c1)N1CCNCC1)(F)F None
4296 10563 80 3H-5HT -24 27 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 230 1 1 2 2.1 FC(c1cccc(c1)N1CCNCC1)(F)F None
CHEMBL274866 10563 80 3H-5HT -24 27 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 230 1 1 2 2.1 FC(c1cccc(c1)N1CCNCC1)(F)F None
5 6927 72 3H-KETANSERIN -144 53 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5202 6927 72 3H-KETANSERIN -144 53 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
CHEMBL39 6927 72 3H-KETANSERIN -144 53 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
DB08839 6927 72 3H-KETANSERIN -144 53 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
1524 8962 96 3H-5HT -36 51 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
197 8962 96 3H-5HT -36 51 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
3822 8962 96 3H-5HT -36 51 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
88 8962 96 3H-5HT -36 51 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
CHEMBL51 8962 96 3H-5HT -36 51 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
DB12465 8962 96 3H-5HT -36 51 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
206 9271 16 3H-5HT -6760 25 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
68848 9271 16 3H-5HT -6760 25 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
CHEMBL12314 9271 16 3H-5HT -6760 25 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C None
2176 9901 68 3H-5HT -31622 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
4828 9901 68 3H-5HT -31622 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
91 9901 68 3H-5HT -31622 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
CHEMBL500 9901 68 3H-5HT -31622 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
DB00960 9901 68 3H-5HT -31622 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C None
243 9976 91 3H-5HT -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
3052762 9976 91 3H-5HT -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
3502 9976 91 3H-5HT -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
CHEMBL117287 9976 91 3H-5HT -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
DB06480 9976 91 3H-5HT -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
130 10273 47 35S-GTPGammaS -2754 13 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 520 3 0 6 5.6 CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C None
3378093 10273 47 35S-GTPGammaS -2754 13 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 520 3 0 6 5.6 CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C None
CHEMBL281350 10273 47 35S-GTPGammaS -2754 13 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 520 3 0 6 5.6 CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C None
2470 10425 50 3H-5HT -2089 58 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3300 10425 50 3H-5HT -2089 58 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
5265 10425 50 3H-5HT -2089 58 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
99 10425 50 3H-5HT -2089 58 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL267930 10425 50 3H-5HT -2089 58 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
108182 10903 22 3H-5HT -32 17 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 309 3 2 4 1.8 COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl None
245 10903 22 3H-5HT -32 17 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 309 3 2 4 1.8 COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl None
CHEMBL18041 10903 22 3H-5HT -32 17 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 309 3 2 4 1.8 COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl None
5656 209845 87 3H-5HT -79 43 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
CHEMBL637 209845 87 3H-5HT -79 43 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
115 10563 80 3H-5HT -24 27 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 230 1 1 2 2.1 FC(c1cccc(c1)N1CCNCC1)(F)F None
4296 10563 80 3H-5HT -24 27 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 230 1 1 2 2.1 FC(c1cccc(c1)N1CCNCC1)(F)F None
CHEMBL274866 10563 80 3H-5HT -24 27 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 230 1 1 2 2.1 FC(c1cccc(c1)N1CCNCC1)(F)F None
107 6929 121 3H-5HT -1778 31 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
1833 6929 121 3H-5HT -1778 31 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
CHEMBL8165 6929 121 3H-5HT -1778 31 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 None
135 9310 43 3H-KETANSERIN -5 56 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
1796 9310 43 3H-KETANSERIN -5 56 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
4184 9310 43 3H-KETANSERIN -5 56 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
CHEMBL6437 9310 43 3H-KETANSERIN -5 56 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
DB06148 9310 43 3H-KETANSERIN -5 56 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
2389 10104 118 3H-5HT -562 66 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 10104 118 3H-5HT -562 66 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 10104 118 3H-5HT -562 66 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 10104 118 3H-5HT -562 66 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 10104 118 3H-5HT -562 66 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5 6927 72 125I-LSD -295 53 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5202 6927 72 125I-LSD -295 53 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
CHEMBL39 6927 72 125I-LSD -295 53 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
DB08839 6927 72 125I-LSD -295 53 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
134 9292 24 125I-LSD -11 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1775 9292 24 125I-LSD -11 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681 9292 24 125I-LSD -11 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
CHEMBL1065 9292 24 125I-LSD -11 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
DB00247 9292 24 125I-LSD -11 67 Rat 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
135398737 7745 93 3H-5HT -19 90 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-5HT -19 90 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-5HT -19 90 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-5HT -19 90 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-5HT -19 90 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
None 222725 0 125I-LSD -112 24 Mouse 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 346 5 4 4 2.5 COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O None
11954224 222732 0 3H-5HT -478 59 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
11954224 222732 0 3H-5HT -478 59 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
11957541 8241 40 3H-5HT -436 16 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 321 4 1 3 2.2 COc1cc(I)c(cc1CC(N)C)OC None
1229 8241 40 3H-5HT -436 16 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 321 4 1 3 2.2 COc1cc(I)c(cc1CC(N)C)OC None
147 8241 40 3H-5HT -436 16 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 321 4 1 3 2.2 COc1cc(I)c(cc1CC(N)C)OC None
170617 8241 40 3H-5HT -436 16 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 321 4 1 3 2.2 COc1cc(I)c(cc1CC(N)C)OC None
CHEMBL6616 8241 40 3H-5HT -436 16 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 321 4 1 3 2.2 COc1cc(I)c(cc1CC(N)C)OC None
1220 6975 55 3H-5HT -1318 44 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
31 6975 55 3H-5HT -1318 44 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
7 6975 55 3H-5HT -1318 44 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
CHEMBL56 6975 55 3H-5HT -1318 44 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC None
152 7152 29 3H-5HT -25 19 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 190 2 3 2 1.8 CC(Cc1c[nH]c2c1cc(O)cc2)N None
2107 7152 29 3H-5HT -25 19 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 190 2 3 2 1.8 CC(Cc1c[nH]c2c1cc(O)cc2)N None
CHEMBL275854 7152 29 3H-5HT -25 19 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 190 2 3 2 1.8 CC(Cc1c[nH]c2c1cc(O)cc2)N None
152 7152 29 3H-5HT -25 19 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 190 2 3 2 1.8 CC(Cc1c[nH]c2c1cc(O)cc2)N None
2107 7152 29 3H-5HT -25 19 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 190 2 3 2 1.8 CC(Cc1c[nH]c2c1cc(O)cc2)N None
CHEMBL275854 7152 29 3H-5HT -25 19 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 190 2 3 2 1.8 CC(Cc1c[nH]c2c1cc(O)cc2)N None
None 222750 0 3H-5HT -446 15 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 473 7 0 5 3.5 COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br None
None 222750 0 3H-5HT -446 15 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 473 7 0 5 3.5 COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br None
2543 10479 68 3H-5HT -5 32 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
5358 10479 68 3H-5HT -5 32 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
54 10479 68 3H-5HT -5 32 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
CHEMBL128 10479 68 3H-5HT -5 32 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
DB00669 10479 68 3H-5HT -5 32 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
2337 10030 77 3H-5HT -35 62 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
50 10030 77 3H-5HT -35 62 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002 10030 77 3H-5HT -35 62 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
CHEMBL716 10030 77 3H-5HT -35 62 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
DB01224 10030 77 3H-5HT -35 62 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
2543 10479 68 3H-5HT -5 32 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
5358 10479 68 3H-5HT -5 32 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
54 10479 68 3H-5HT -5 32 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
CHEMBL128 10479 68 3H-5HT -5 32 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
DB00669 10479 68 3H-5HT -5 32 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
1150 10650 121 3H-5HT -107 25 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
125 10650 121 3H-5HT -107 25 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
CHEMBL6640 10650 121 3H-5HT -107 25 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
DB08653 10650 121 3H-5HT -107 25 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 None
1809 6922 32 125I-LSD -26915 37 Rat 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
4 6922 32 125I-LSD -26915 37 Rat 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
CHEMBL18840 6922 32 125I-LSD -26915 37 Rat 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
11957541 8241 40 3H-KETANSERIN -436 16 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 321 4 1 3 2.2 COc1cc(I)c(cc1CC(N)C)OC None
1229 8241 40 3H-KETANSERIN -436 16 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 321 4 1 3 2.2 COc1cc(I)c(cc1CC(N)C)OC None
147 8241 40 3H-KETANSERIN -436 16 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 321 4 1 3 2.2 COc1cc(I)c(cc1CC(N)C)OC None
170617 8241 40 3H-KETANSERIN -436 16 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 321 4 1 3 2.2 COc1cc(I)c(cc1CC(N)C)OC None
CHEMBL6616 8241 40 3H-KETANSERIN -436 16 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 321 4 1 3 2.2 COc1cc(I)c(cc1CC(N)C)OC None
2470 10425 50 3H-KETANSERIN -2089 58 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3300 10425 50 3H-KETANSERIN -2089 58 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
5265 10425 50 3H-KETANSERIN -2089 58 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
99 10425 50 3H-KETANSERIN -2089 58 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL267930 10425 50 3H-KETANSERIN -2089 58 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
None 222831 0 3H-5HT -87 8 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 339 4 3 3 1.9 CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C None
None 222831 0 3H-5HT -87 8 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 339 4 3 3 1.9 CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C None
10257 7525 31 125I-LSD -12 19 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 204 3 2 2 2.0 CN(CCc1c[nH]c2c1cc(O)cc2)C None
144 7525 31 125I-LSD -12 19 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 204 3 2 2 2.0 CN(CCc1c[nH]c2c1cc(O)cc2)C None
CHEMBL416526 7525 31 125I-LSD -12 19 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 204 3 2 2 2.0 CN(CCc1c[nH]c2c1cc(O)cc2)C None
DB01445 7525 31 125I-LSD -12 19 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 204 3 2 2 2.0 CN(CCc1c[nH]c2c1cc(O)cc2)C None
135398745 9688 112 3H-5HT -43 65 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 9688 112 3H-5HT -43 65 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 9688 112 3H-5HT -43 65 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 9688 112 3H-5HT -43 65 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
3652 10869 79 3H-5HT -12 18 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C None
57 10869 79 3H-5HT -12 18 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C None
60809 10869 79 3H-5HT -12 18 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C None
CHEMBL21536 10869 79 3H-5HT -12 18 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C None
DB15357 10869 79 3H-5HT -12 18 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C None
1809 6922 32 125I-LSD -34673 37 Mouse 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
4 6922 32 125I-LSD -34673 37 Mouse 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
CHEMBL18840 6922 32 125I-LSD -34673 37 Mouse 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
134 9292 24 3H-5HT -10 67 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1775 9292 24 3H-5HT -10 67 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681 9292 24 3H-5HT -10 67 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
CHEMBL1065 9292 24 3H-5HT -10 67 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
DB00247 9292 24 3H-5HT -10 67 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
133 9274 52 3H-5HT -165 43 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1723 9274 52 3H-5HT -165 43 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
28693 9274 52 3H-5HT -165 43 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
CHEMBL19215 9274 52 3H-5HT -165 43 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
DB13520 9274 52 3H-5HT -165 43 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
134 9292 24 3H-5HT -10 67 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1775 9292 24 3H-5HT -10 67 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681 9292 24 3H-5HT -10 67 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
CHEMBL1065 9292 24 3H-5HT -10 67 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
DB00247 9292 24 3H-5HT -10 67 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
133 9274 52 3H-5HT -165 43 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1723 9274 52 3H-5HT -165 43 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
28693 9274 52 3H-5HT -165 43 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
CHEMBL19215 9274 52 3H-5HT -165 43 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
DB13520 9274 52 3H-5HT -165 43 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
2435 10362 83 3H-5HT -190 48 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
60149 10362 83 3H-5HT -190 48 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
98 10362 83 3H-5HT -190 48 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
CHEMBL12713 10362 83 3H-5HT -190 48 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
DB06144 10362 83 3H-5HT -190 48 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
145 6928 49 3H-5HT -7 30 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
1832 6928 49 3H-5HT -7 30 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
CHEMBL7257 6928 49 3H-5HT -7 30 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
DB14010 6928 49 3H-5HT -7 30 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
145 6928 49 3H-5HT -7 30 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
1832 6928 49 3H-5HT -7 30 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
CHEMBL7257 6928 49 3H-5HT -7 30 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
DB14010 6928 49 3H-5HT -7 30 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
6852400 222716 0 3H-KETANSERIN -9772 22 Human 5.4 pKi = 5.4 Binding
NoneNone
PDSP KiDatabase 361 0 1 2 4.8 CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O None
73759726 222716 0 3H-KETANSERIN -9772 22 Human 5.4 pKi = 5.4 Binding
NoneNone
PDSP KiDatabase 361 0 1 2 4.8 CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O None
107780 8625 54 3H-5HT -269 18 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 497 6 1 7 5.0 COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C None
14 8625 54 3H-5HT -269 18 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 497 6 1 7 5.0 COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C None
CHEMBL15928 8625 54 3H-5HT -269 18 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 497 6 1 7 5.0 COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C None
1574 6869 60 3H-5HT -4 21 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 190 2 3 2 1.7 Cc1c(CCN)c2c([nH]1)ccc(c2)O None
218 6869 60 3H-5HT -4 21 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 190 2 3 2 1.7 Cc1c(CCN)c2c([nH]1)ccc(c2)O None
CHEMBL266591 6869 60 3H-5HT -4 21 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 190 2 3 2 1.7 Cc1c(CCN)c2c([nH]1)ccc(c2)O None
1574 6869 60 3H-5HT -4 21 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 190 2 3 2 1.7 Cc1c(CCN)c2c([nH]1)ccc(c2)O None
218 6869 60 3H-5HT -4 21 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 190 2 3 2 1.7 Cc1c(CCN)c2c([nH]1)ccc(c2)O None
CHEMBL266591 6869 60 3H-5HT -4 21 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 190 2 3 2 1.7 Cc1c(CCN)c2c([nH]1)ccc(c2)O None
202 8290 77 3H-5HT -1 33 Human 5.4 pKi = 5.4 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
60835 8290 77 3H-5HT -1 33 Human 5.4 pKi = 5.4 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
972 8290 77 3H-5HT -1 33 Human 5.4 pKi = 5.4 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
CHEMBL1175 8290 77 3H-5HT -1 33 Human 5.4 pKi = 5.4 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
DB00476 8290 77 3H-5HT -1 33 Human 5.4 pKi = 5.4 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
2337 10030 77 None -35 62 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
50 10030 77 None -35 62 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002 10030 77 None -35 62 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
CHEMBL716 10030 77 None -35 62 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
DB01224 10030 77 None -35 62 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
2389 10104 118 None -562 66 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 10104 118 None -562 66 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 10104 118 None -562 66 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 10104 118 None -562 66 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 10104 118 None -562 66 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
11954224 222732 0 125I-LSD -707 59 Mouse 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
1353 8692 93 3H-5HT -112 85 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 8692 93 3H-5HT -112 85 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 8692 93 3H-5HT -112 85 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 8692 93 3H-5HT -112 85 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 8692 93 3H-5HT -112 85 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
2181 9902 46 3H-5HT -134 34 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
4830 9902 46 3H-5HT -134 34 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
92 9902 46 3H-5HT -134 34 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
CHEMBL440294 9902 46 3H-5HT -134 34 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
DB09286 9902 46 3H-5HT -134 34 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
189 10265 39 3H-5HT -2089 17 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 292 1 1 3 3.2 O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1 None
5163 10265 39 3H-5HT -2089 17 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 292 1 1 3 3.2 O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1 None
CHEMBL297784 10265 39 3H-5HT -2089 17 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 292 1 1 3 3.2 O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1 None
133 9274 52 3H-5HT -954 43 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1723 9274 52 3H-5HT -954 43 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
28693 9274 52 3H-5HT -954 43 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
CHEMBL19215 9274 52 3H-5HT -954 43 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
DB13520 9274 52 3H-5HT -954 43 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
11954224 222732 0 125I-LSD -741 59 Rat 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
1342 6824 49 3H-5HT -21 19 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 None
3 6824 49 3H-5HT -21 19 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 None
CHEMBL277120 6824 49 3H-5HT -21 19 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 None
1342 6824 49 3H-5HT -21 19 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 None
3 6824 49 3H-5HT -21 19 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 None
CHEMBL277120 6824 49 3H-5HT -21 19 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 None
102 10899 48 125I-LSD -1412 49 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
3659 10899 48 125I-LSD -1412 49 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
8969 10899 48 125I-LSD -1412 49 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
CHEMBL15245 10899 48 125I-LSD -1412 49 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
DB01392 10899 48 125I-LSD -1412 49 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
18971832 9196 0 3H-5HT 83 13 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 351 3 2 2 4.0 CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C None
21 9196 0 3H-5HT 83 13 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 351 3 2 2 4.0 CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C None
CHEMBL3186179 9196 0 3H-5HT 83 13 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 351 3 2 2 4.0 CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C None
134 9292 24 125I-LSD -5 67 Mouse 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1775 9292 24 125I-LSD -5 67 Mouse 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681 9292 24 125I-LSD -5 67 Mouse 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
CHEMBL1065 9292 24 125I-LSD -5 67 Mouse 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
DB00247 9292 24 125I-LSD -5 67 Mouse 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
2435 10362 83 None -190 48 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
60149 10362 83 None -190 48 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
98 10362 83 None -190 48 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
CHEMBL12713 10362 83 None -190 48 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
DB06144 10362 83 None -190 48 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
133 9274 52 None -165 43 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1723 9274 52 None -165 43 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
28693 9274 52 None -165 43 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
CHEMBL19215 9274 52 None -165 43 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
DB13520 9274 52 None -165 43 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
3652 10869 79 None -12 18 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C None
57 10869 79 None -12 18 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C None
60809 10869 79 None -12 18 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C None
CHEMBL21536 10869 79 None -12 18 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C None
DB15357 10869 79 None -12 18 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C None
135398745 9688 112 None -43 65 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 9688 112 None -43 65 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 9688 112 None -43 65 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 9688 112 None -43 65 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
2393 10107 82 None -3 5 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 269 5 1 4 1.9 CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C None
5078 10107 82 None -3 5 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 269 5 1 4 1.9 CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C None
51 10107 82 None -3 5 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 269 5 1 4 1.9 CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C None
CHEMBL905 10107 82 None -3 5 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 269 5 1 4 1.9 CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C None
DB00953 10107 82 None -3 5 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 269 5 1 4 1.9 CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C None
11954224 222732 0 None -478 59 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
135398737 7745 93 None -19 90 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 None -19 90 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 None -19 90 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 None -19 90 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 None -19 90 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
102 10899 48 125I-LSD -158 49 Mouse 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
3659 10899 48 125I-LSD -158 49 Mouse 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
8969 10899 48 125I-LSD -158 49 Mouse 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
CHEMBL15245 10899 48 125I-LSD -158 49 Mouse 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
DB01392 10899 48 125I-LSD -158 49 Mouse 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
None 222993 0 3H-5HT -562 14 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 438 5 1 4 4.8 C1CC(CCC1CCN2CCC3=C(C2)C=CC(=C3)C#N)NC(=O)C4=CC=NC5=CC=CC=C45 None
2543 10479 68 125I-LSD -18 32 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
5358 10479 68 125I-LSD -18 32 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
54 10479 68 125I-LSD -18 32 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
CHEMBL128 10479 68 125I-LSD -18 32 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
DB00669 10479 68 125I-LSD -18 32 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
4106 9280 22 3H-5HT -1584 33 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
5358812 9280 22 3H-5HT -1584 33 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
89 9280 22 3H-5HT -1584 33 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
CHEMBL93240 9280 22 3H-5HT -1584 33 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
4106 9280 22 3H-5HT -1584 33 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
5358812 9280 22 3H-5HT -1584 33 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
89 9280 22 3H-5HT -1584 33 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
CHEMBL93240 9280 22 3H-5HT -1584 33 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C None
5 6927 72 125I-LSD -158 53 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5202 6927 72 125I-LSD -158 53 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
CHEMBL39 6927 72 125I-LSD -158 53 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
DB08839 6927 72 125I-LSD -158 53 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
102 10899 48 None -100 49 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
3659 10899 48 None -100 49 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
8969 10899 48 None -100 49 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
CHEMBL15245 10899 48 None -100 49 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
DB01392 10899 48 None -100 49 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
10531 8202 21 None -83 24 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
121 8202 21 None -83 24 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
888 8202 21 None -83 24 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
CHEMBL1732 8202 21 None -83 24 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
DB00320 8202 21 None -83 24 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
123606 7140 70 None 1 3 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 335 6 1 3 2.2 CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C None
128 7140 70 None 1 3 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 335 6 1 3 2.2 CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C None
7110 7140 70 None 1 3 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 335 6 1 3 2.2 CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C None
CHEMBL1505 7140 70 None 1 3 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 335 6 1 3 2.2 CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C None
DB00918 7140 70 None 1 3 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 335 6 1 3 2.2 CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C None
2869 10924 89 None -25 7 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 287 5 2 3 1.9 CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C None
60 10924 89 None -25 7 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 287 5 2 3 1.9 CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C None
60857 10924 89 None -25 7 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 287 5 2 3 1.9 CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C None
CHEMBL1185 10924 89 None -25 7 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 287 5 2 3 1.9 CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C None
DB00315 10924 89 None -25 7 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 287 5 2 3 1.9 CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C None
150 9287 21 None -11 16 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO None
1764 9287 21 None -11 16 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO None
8226 9287 21 None -11 16 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO None
CHEMBL1201356 9287 21 None -11 16 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO None
DB00353 9287 21 None -11 16 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO None
2543 10479 68 None -5 32 Human 8.1 pKi = 8.1 Binding
Binding affinity towards human 5-hydroxytryptamine 1F receptor was determinedBinding affinity towards human 5-hydroxytryptamine 1F receptor was determined
Drug Central 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
5358 10479 68 None -5 32 Human 8.1 pKi = 8.1 Binding
Binding affinity towards human 5-hydroxytryptamine 1F receptor was determinedBinding affinity towards human 5-hydroxytryptamine 1F receptor was determined
Drug Central 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
54 10479 68 None -5 32 Human 8.1 pKi = 8.1 Binding
Binding affinity towards human 5-hydroxytryptamine 1F receptor was determinedBinding affinity towards human 5-hydroxytryptamine 1F receptor was determined
Drug Central 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
CHEMBL128 10479 68 None -5 32 Human 8.1 pKi = 8.1 Binding
Binding affinity towards human 5-hydroxytryptamine 1F receptor was determinedBinding affinity towards human 5-hydroxytryptamine 1F receptor was determined
Drug Central 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
DB00669 10479 68 None -5 32 Human 8.1 pKi = 8.1 Binding
Binding affinity towards human 5-hydroxytryptamine 1F receptor was determinedBinding affinity towards human 5-hydroxytryptamine 1F receptor was determined
Drug Central 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
1809 6922 32 3H-5HT -8317 37 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
4 6922 32 3H-5HT -8317 37 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
CHEMBL18840 6922 32 3H-5HT -8317 37 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
1809 6922 32 3H-5HT -8317 37 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
4 6922 32 3H-5HT -8317 37 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
CHEMBL18840 6922 32 3H-5HT -8317 37 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N None
2543 10479 68 125I-LSD -22 32 Mouse 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
5358 10479 68 125I-LSD -22 32 Mouse 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
54 10479 68 125I-LSD -22 32 Mouse 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
CHEMBL128 10479 68 125I-LSD -22 32 Mouse 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
DB00669 10479 68 125I-LSD -22 32 Mouse 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 None
115 10563 80 125I-LSD -19 27 Mouse 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 230 1 1 2 2.1 FC(c1cccc(c1)N1CCNCC1)(F)F None
4296 10563 80 125I-LSD -19 27 Mouse 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 230 1 1 2 2.1 FC(c1cccc(c1)N1CCNCC1)(F)F None
CHEMBL274866 10563 80 125I-LSD -19 27 Mouse 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 230 1 1 2 2.1 FC(c1cccc(c1)N1CCNCC1)(F)F None
None 223229 0 3H-5HT -524 28 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 322 5 2 3 4.1 CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl None
None 223229 0 UNDEFINED -524 28 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 322 5 2 3 4.1 CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl None
40 8329 58 None -2 5 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 382 6 1 3 3.8 CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 None
77993 8329 58 None -2 5 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 382 6 1 3 3.8 CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 None
995 8329 58 None -2 5 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 382 6 1 3 3.8 CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 None
CHEMBL1510 8329 58 None -2 5 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 382 6 1 3 3.8 CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 None
DB00216 8329 58 None -2 5 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 382 6 1 3 3.8 CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 None
135 9310 43 None -5 56 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
1796 9310 43 None -5 56 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
4184 9310 43 None -5 56 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
CHEMBL6437 9310 43 None -5 56 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
DB06148 9310 43 None -5 56 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
134 9292 24 None -10 67 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1775 9292 24 None -10 67 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681 9292 24 None -10 67 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
CHEMBL1065 9292 24 None -10 67 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
DB00247 9292 24 None -10 67 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1884 9512 58 None -3 5 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 335 5 2 3 2.1 CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C None
4440 9512 58 None -3 5 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 335 5 2 3 2.1 CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C None
45 9512 58 None -3 5 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 335 5 2 3 2.1 CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C None
CHEMBL1278 9512 58 None -3 5 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 335 5 2 3 2.1 CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C None
DB00952 9512 58 None -3 5 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 335 5 2 3 2.1 CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C None
2470 10425 50 None -2089 58 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3300 10425 50 None -2089 58 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
5265 10425 50 None -2089 58 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
99 10425 50 None -2089 58 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL267930 10425 50 None -2089 58 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
11610526 9062 64 None - 1 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 377 4 1 4 3.3 CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F None
3928 9062 64 None - 1 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 377 4 1 4 3.3 CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F None
5351 9062 64 None - 1 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 377 4 1 4 3.3 CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F None
CHEMBL3039520 9062 64 None - 1 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 377 4 1 4 3.3 CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F None
DB11732 9062 64 None - 1 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 377 4 1 4 3.3 CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F None
1524 8962 96 None -36 51 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
197 8962 96 None -36 51 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
3822 8962 96 None -36 51 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
88 8962 96 None -36 51 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
CHEMBL51 8962 96 None -36 51 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
DB12465 8962 96 None -36 51 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
102 10899 48 3H-5HT -100 49 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
3659 10899 48 3H-5HT -100 49 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
8969 10899 48 3H-5HT -100 49 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
CHEMBL15245 10899 48 3H-5HT -100 49 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
DB01392 10899 48 3H-5HT -100 49 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
102 10899 48 3H-5HT -100 49 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
3659 10899 48 3H-5HT -100 49 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
8969 10899 48 3H-5HT -100 49 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
CHEMBL15245 10899 48 3H-5HT -100 49 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
DB01392 10899 48 3H-5HT -100 49 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
2543 10479 68 None -5 32 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10193663
2543 10479 68 None -5 32 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 15900510
2543 10479 68 None -5 32 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 8380639
2543 10479 68 None -5 32 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 9225282
5358 10479 68 None -5 32 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10193663
5358 10479 68 None -5 32 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 15900510
5358 10479 68 None -5 32 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 8380639
5358 10479 68 None -5 32 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 9225282
54 10479 68 None -5 32 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10193663
54 10479 68 None -5 32 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 15900510
54 10479 68 None -5 32 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 8380639
54 10479 68 None -5 32 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 9225282
CHEMBL128 10479 68 None -5 32 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10193663
CHEMBL128 10479 68 None -5 32 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 15900510
CHEMBL128 10479 68 None -5 32 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 8380639
CHEMBL128 10479 68 None -5 32 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 9225282
DB00669 10479 68 None -5 32 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10193663
DB00669 10479 68 None -5 32 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 15900510
DB00669 10479 68 None -5 32 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 8380639
DB00669 10479 68 None -5 32 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 9225282
40 8329 58 None -2 5 Human 8.0 pKi = 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 382 6 1 3 3.8 CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 10193663
77993 8329 58 None -2 5 Human 8.0 pKi = 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 382 6 1 3 3.8 CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 10193663
995 8329 58 None -2 5 Human 8.0 pKi = 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 382 6 1 3 3.8 CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 10193663
CHEMBL1510 8329 58 None -2 5 Human 8.0 pKi = 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 382 6 1 3 3.8 CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 10193663
DB00216 8329 58 None -2 5 Human 8.0 pKi = 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 382 6 1 3 3.8 CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 10193663
18971832 9196 0 None 83 13 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 351 3 2 2 4.0 CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C 9395253
21 9196 0 None 83 13 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 351 3 2 2 4.0 CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C 9395253
CHEMBL3186179 9196 0 None 83 13 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 351 3 2 2 4.0 CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C 9395253
8422 6917 0 None 66 2 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 272 7 1 2 3.2 CCCC(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 21422162
91827360 6917 0 None 66 2 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 272 7 1 2 3.2 CCCC(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 21422162
11610526 9062 64 None - 1 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 377 4 1 4 3.3 CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F 20855361
3928 9062 64 None - 1 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 377 4 1 4 3.3 CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F 20855361
5351 9062 64 None - 1 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 377 4 1 4 3.3 CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F 20855361
CHEMBL3039520 9062 64 None - 1 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 377 4 1 4 3.3 CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F 20855361
DB11732 9062 64 None - 1 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 377 4 1 4 3.3 CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F 20855361
151 9194 44 None 14 4 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F 15900510
20 9194 44 None 14 4 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F 15900510
5311258 9194 44 None 14 4 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F 15900510
CHEMBL101690 9194 44 None 14 4 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F 15900510
2438 7514 92 None 1 2 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 230 1 2 2 2.7 CN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 None
3927 7514 92 None 1 2 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 230 1 2 2 2.7 CN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 None
CHEMBL1371156 7514 92 None 1 2 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 230 1 2 2 2.7 CN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 None
1353 8692 93 None -112 85 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 8692 93 None -112 85 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 8692 93 None -112 85 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 8692 93 None -112 85 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 8692 93 None -112 85 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
2181 9902 46 None -134 34 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
4830 9902 46 None -134 34 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
92 9902 46 None -134 34 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
CHEMBL440294 9902 46 None -134 34 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
DB09286 9902 46 None -134 34 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
202 8290 77 None -1 33 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
60835 8290 77 None -1 33 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
972 8290 77 None -1 33 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
CHEMBL1175 8290 77 None -1 33 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
DB00476 8290 77 None -1 33 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
197706 8246 0 None -15848 10 Human 5.5 pKi None 5.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 6 2 5 2.3 NCCc1c[nH]c2c1cc(OCC(=O)N1CCN(CC1)c1ccc(cc1)C#N)cc2 10381763
39 8246 0 None -15848 10 Human 5.5 pKi None 5.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 6 2 5 2.3 NCCc1c[nH]c2c1cc(OCC(=O)N1CCN(CC1)c1ccc(cc1)C#N)cc2 10381763
CHEMBL1742428 8246 0 None -15848 10 Human 5.5 pKi None 5.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 6 2 5 2.3 NCCc1c[nH]c2c1cc(OCC(=O)N1CCN(CC1)c1ccc(cc1)C#N)cc2 10381763
2337 10030 77 None -35 62 Human 5.6 pKi None 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 8935801
50 10030 77 None -35 62 Human 5.6 pKi None 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 8935801
5002 10030 77 None -35 62 Human 5.6 pKi None 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 8935801
CHEMBL716 10030 77 None -35 62 Human 5.6 pKi None 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 8935801
DB01224 10030 77 None -35 62 Human 5.6 pKi None 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 8935801
1150 10650 121 None -107 25 Human 5.6 pKi None 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 8380639
125 10650 121 None -107 25 Human 5.6 pKi None 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 8380639
CHEMBL6640 10650 121 None -107 25 Human 5.6 pKi None 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 8380639
DB08653 10650 121 None -107 25 Human 5.6 pKi None 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 160 2 2 1 1.7 NCCc1c[nH]c2c1cccc2 8380639
1220 6975 55 None -1318 44 Human 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 8380639
31 6975 55 None -1318 44 Human 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 8380639
7 6975 55 None -1318 44 Human 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 8380639
CHEMBL56 6975 55 None -1318 44 Human 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 8380639
122 8219 9 None -316 11 Human 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 8 2 2 2.9 CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N 8380639
156314 8219 9 None -316 11 Human 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 8 2 2 2.9 CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N 8380639
CHEMBL1332062 8219 9 None -316 11 Human 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 8 2 2 2.9 CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N 8380639
11957541 8241 40 None -436 16 Human 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 321 4 1 3 2.2 COc1cc(I)c(cc1CC(N)C)OC 8380639
1229 8241 40 None -436 16 Human 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 321 4 1 3 2.2 COc1cc(I)c(cc1CC(N)C)OC 8380639
147 8241 40 None -436 16 Human 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 321 4 1 3 2.2 COc1cc(I)c(cc1CC(N)C)OC 8380639
170617 8241 40 None -436 16 Human 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 321 4 1 3 2.2 COc1cc(I)c(cc1CC(N)C)OC 8380639
CHEMBL6616 8241 40 None -436 16 Human 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 321 4 1 3 2.2 COc1cc(I)c(cc1CC(N)C)OC 8380639
107 6929 121 None -1778 31 Human 5.9 pKi None 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 8380639
1833 6929 121 None -1778 31 Human 5.9 pKi None 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 8380639
CHEMBL8165 6929 121 None -1778 31 Human 5.9 pKi None 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2 8380639
2389 10104 118 None -562 66 Human 5.9 pKi None 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 8935801
5073 10104 118 None -562 66 Human 5.9 pKi None 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 8935801
96 10104 118 None -562 66 Human 5.9 pKi None 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 8935801
CHEMBL85 10104 118 None -562 66 Human 5.9 pKi None 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 8935801
DB00734 10104 118 None -562 66 Human 5.9 pKi None 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 8935801
10 7510 28 None -79 9 Human 6.0 pKi None 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 406 6 1 3 4.7 Clc1cccc(c1)N1CCN(CC1)CC(C(c1ccccc1)c1ccccc1)O 9303567
3654103 7510 28 None -79 9 Human 6.0 pKi None 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 406 6 1 3 4.7 Clc1cccc(c1)N1CCN(CC1)CC(C(c1ccccc1)c1ccccc1)O 9303567
CHEMBL534232 7510 28 None -79 9 Human 6.0 pKi None 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 406 6 1 3 4.7 Clc1cccc(c1)N1CCN(CC1)CC(C(c1ccccc1)c1ccccc1)O 9303567
115 10563 80 None -24 27 Human 6.0 pKi None 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 230 1 1 2 2.1 FC(c1cccc(c1)N1CCNCC1)(F)F 8380639
4296 10563 80 None -24 27 Human 6.0 pKi None 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 230 1 1 2 2.1 FC(c1cccc(c1)N1CCNCC1)(F)F 8380639
CHEMBL274866 10563 80 None -24 27 Human 6.0 pKi None 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 230 1 1 2 2.1 FC(c1cccc(c1)N1CCNCC1)(F)F 8380639
1809 6922 32 None -8317 37 Human 6.1 pKi None 6.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 8380639
1809 6922 32 None -8317 37 Human 6.1 pKi None 6.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 9225282
4 6922 32 None -8317 37 Human 6.1 pKi None 6.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 8380639
4 6922 32 None -8317 37 Human 6.1 pKi None 6.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 9225282
CHEMBL18840 6922 32 None -8317 37 Human 6.1 pKi None 6.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 8380639
CHEMBL18840 6922 32 None -8317 37 Human 6.1 pKi None 6.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N 9225282
4106 9280 22 None -1584 33 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 8380639
4106 9280 22 None -1584 33 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 9225282
5358812 9280 22 None -1584 33 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 8380639
5358812 9280 22 None -1584 33 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 9225282
89 9280 22 None -1584 33 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 8380639
89 9280 22 None -1584 33 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 9225282
CHEMBL93240 9280 22 None -1584 33 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 8380639
CHEMBL93240 9280 22 None -1584 33 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 9225282
1574 6869 60 None -4 21 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 190 2 3 2 1.7 Cc1c(CCN)c2c([nH]1)ccc(c2)O 8380639
218 6869 60 None -4 21 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 190 2 3 2 1.7 Cc1c(CCN)c2c([nH]1)ccc(c2)O 8380639
CHEMBL266591 6869 60 None -4 21 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 190 2 3 2 1.7 Cc1c(CCN)c2c([nH]1)ccc(c2)O 8380639
2435 10362 83 None -190 48 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 8935801
60149 10362 83 None -190 48 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 8935801
98 10362 83 None -190 48 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 8935801
CHEMBL12713 10362 83 None -190 48 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 8935801
DB06144 10362 83 None -190 48 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 8935801
133 9274 52 None -165 43 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8380639
133 9274 52 None -165 43 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 9225282
1723 9274 52 None -165 43 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8380639
1723 9274 52 None -165 43 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 9225282
28693 9274 52 None -165 43 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8380639
28693 9274 52 None -165 43 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 9225282
CHEMBL19215 9274 52 None -165 43 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8380639
CHEMBL19215 9274 52 None -165 43 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 9225282
DB13520 9274 52 None -165 43 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 8380639
DB13520 9274 52 None -165 43 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C 9225282
135398745 9688 112 None -43 65 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 8935801
47 9688 112 None -43 65 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 8935801
CHEMBL715 9688 112 None -43 65 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 8935801
DB00334 9688 112 None -43 65 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 8935801
3652 10869 79 None -12 18 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C 9884068
57 10869 79 None -12 18 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C 9884068
60809 10869 79 None -12 18 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C 9884068
CHEMBL21536 10869 79 None -12 18 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C 9884068
DB15357 10869 79 None -12 18 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C 9884068
2393 10107 82 None -3 5 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 269 5 1 4 1.9 CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C 10193663
2393 10107 82 None -3 5 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 269 5 1 4 1.9 CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C 15900510
5078 10107 82 None -3 5 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 269 5 1 4 1.9 CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C 10193663
5078 10107 82 None -3 5 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 269 5 1 4 1.9 CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C 15900510
51 10107 82 None -3 5 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 269 5 1 4 1.9 CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C 10193663
51 10107 82 None -3 5 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 269 5 1 4 1.9 CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C 15900510
CHEMBL905 10107 82 None -3 5 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 269 5 1 4 1.9 CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C 10193663
CHEMBL905 10107 82 None -3 5 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 269 5 1 4 1.9 CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C 15900510
DB00953 10107 82 None -3 5 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 269 5 1 4 1.9 CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C 10193663
DB00953 10107 82 None -3 5 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 269 5 1 4 1.9 CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C 15900510
152 7152 29 None -25 19 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 190 2 3 2 1.8 CC(Cc1c[nH]c2c1cc(O)cc2)N 8380639
2107 7152 29 None -25 19 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 190 2 3 2 1.8 CC(Cc1c[nH]c2c1cc(O)cc2)N 8380639
CHEMBL275854 7152 29 None -25 19 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 190 2 3 2 1.8 CC(Cc1c[nH]c2c1cc(O)cc2)N 8380639
4431 9506 25 None -575 12 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 393 7 0 5 2.9 COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 8380639
73 9506 25 None -575 12 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 393 7 0 5 2.9 COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 8380639
CHEMBL8618 9506 25 None -575 12 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 393 7 0 5 2.9 COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 8380639
107780 8625 54 None -269 18 Human 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 497 6 1 7 5.0 COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C 15900510
107780 8625 54 None -269 18 Human 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 497 6 1 7 5.0 COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C 9303567
14 8625 54 None -269 18 Human 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 497 6 1 7 5.0 COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C 15900510
14 8625 54 None -269 18 Human 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 497 6 1 7 5.0 COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C 9303567
CHEMBL15928 8625 54 None -269 18 Human 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 497 6 1 7 5.0 COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C 15900510
CHEMBL15928 8625 54 None -269 18 Human 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 497 6 1 7 5.0 COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C 9303567
1043 8363 14 None -1737 29 Human 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 8380639
149 8363 14 None -1737 29 Human 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 8380639
8223 8363 14 None -1737 29 Human 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 8380639
CHEMBL442 8363 14 None -1737 29 Human 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 8380639
DB00696 8363 14 None -1737 29 Human 6.8 pKi None 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 8380639
10531 8202 21 None -83 24 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 15900510
10531 8202 21 None -83 24 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 9225282
121 8202 21 None -83 24 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 15900510
121 8202 21 None -83 24 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 9225282
888 8202 21 None -83 24 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 15900510
888 8202 21 None -83 24 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 9225282
CHEMBL1732 8202 21 None -83 24 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 15900510
CHEMBL1732 8202 21 None -83 24 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 9225282
DB00320 8202 21 None -83 24 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 15900510
DB00320 8202 21 None -83 24 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 9225282
135398737 7745 93 None -19 90 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 8935801
38 7745 93 None -19 90 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 8935801
722 7745 93 None -19 90 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 8935801
CHEMBL42 7745 93 None -19 90 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 8935801
DB00363 7745 93 None -19 90 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 8935801
102 10899 48 None -100 49 Human 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 8380639
3659 10899 48 None -100 49 Human 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 8380639
8969 10899 48 None -100 49 Human 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 8380639
CHEMBL15245 10899 48 None -100 49 Human 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 8380639
DB01392 10899 48 None -100 49 Human 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 8380639
1342 6824 49 None -21 19 Human 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 8380639
1342 6824 49 None -21 19 Human 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 9225282
3 6824 49 None -21 19 Human 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 8380639
3 6824 49 None -21 19 Human 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 9225282
CHEMBL277120 6824 49 None -21 19 Human 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 8380639
CHEMBL277120 6824 49 None -21 19 Human 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 212 1 1 2 2.2 N1CCN(CC1)c1cccc2c1cccc2 9225282
145 6928 49 None -7 30 Human 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 8380639
1832 6928 49 None -7 30 Human 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 8380639
CHEMBL7257 6928 49 None -7 30 Human 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 8380639
DB14010 6928 49 None -7 30 Human 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2 8380639
2869 10924 89 None -25 7 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 5 2 3 1.9 CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C 10193663
2869 10924 89 None -25 7 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 5 2 3 1.9 CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C 15900510
60 10924 89 None -25 7 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 5 2 3 1.9 CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C 10193663
60 10924 89 None -25 7 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 5 2 3 1.9 CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C 15900510
60857 10924 89 None -25 7 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 5 2 3 1.9 CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C 10193663
60857 10924 89 None -25 7 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 5 2 3 1.9 CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C 15900510
CHEMBL1185 10924 89 None -25 7 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 5 2 3 1.9 CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C 10193663
CHEMBL1185 10924 89 None -25 7 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 5 2 3 1.9 CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C 15900510
DB00315 10924 89 None -25 7 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 5 2 3 1.9 CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C 10193663
DB00315 10924 89 None -25 7 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 5 2 3 1.9 CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C 15900510
150 9287 21 None -11 16 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO 8380639
1764 9287 21 None -11 16 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO 8380639
8226 9287 21 None -11 16 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO 8380639
CHEMBL1201356 9287 21 None -11 16 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO 8380639
DB00353 9287 21 None -11 16 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO 8380639
5 6927 72 None -144 53 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 15900510
5 6927 72 None -144 53 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 8380639
5 6927 72 None -144 53 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 9225282
5202 6927 72 None -144 53 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 15900510
5202 6927 72 None -144 53 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 8380639
5202 6927 72 None -144 53 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 9225282
CHEMBL39 6927 72 None -144 53 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 15900510
CHEMBL39 6927 72 None -144 53 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 8380639
CHEMBL39 6927 72 None -144 53 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 9225282
DB08839 6927 72 None -144 53 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 15900510
DB08839 6927 72 None -144 53 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 8380639
DB08839 6927 72 None -144 53 Human 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 9225282
134 9292 24 None -10 67 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 15900510
134 9292 24 None -10 67 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 8380639
1775 9292 24 None -10 67 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 15900510
1775 9292 24 None -10 67 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 8380639
9681 9292 24 None -10 67 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 15900510
9681 9292 24 None -10 67 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 8380639
CHEMBL1065 9292 24 None -10 67 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 15900510
CHEMBL1065 9292 24 None -10 67 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 8380639
DB00247 9292 24 None -10 67 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 15900510
DB00247 9292 24 None -10 67 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 8380639
1884 9512 58 None -3 5 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 335 5 2 3 2.1 CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C 10193663
1884 9512 58 None -3 5 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 335 5 2 3 2.1 CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C 15900510
4440 9512 58 None -3 5 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 335 5 2 3 2.1 CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C 10193663
4440 9512 58 None -3 5 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 335 5 2 3 2.1 CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C 15900510
45 9512 58 None -3 5 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 335 5 2 3 2.1 CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C 10193663
45 9512 58 None -3 5 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 335 5 2 3 2.1 CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C 15900510
CHEMBL1278 9512 58 None -3 5 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 335 5 2 3 2.1 CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C 10193663
CHEMBL1278 9512 58 None -3 5 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 335 5 2 3 2.1 CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C 15900510
DB00952 9512 58 None -3 5 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 335 5 2 3 2.1 CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C 10193663
DB00952 9512 58 None -3 5 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 335 5 2 3 2.1 CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C 15900510