Biased Signaling Atlas

Ligand source activities (1 row/activity)

Potency
Affinity

Get vendors

Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	5	139	66	None	-2	27	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2020.127511
	5202	139	66	None	-2	27	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2020.127511
	CHEMBL39	139	66	None	-2	27	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2020.127511
	DB08839	139	66	None	-2	27	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2020.127511
	5	139	66	None	-2	27	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	5202	139	66	None	-2	27	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	CHEMBL39	139	66	None	-2	27	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	DB08839	139	66	None	-2	27	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	5	139	66	None	-2	27	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	5202	139	66	None	-2	27	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	CHEMBL39	139	66	None	-2	27	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	DB08839	139	66	None	-2	27	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	5	139	66	None	-2	27	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm801354e
	5202	139	66	None	-2	27	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm801354e
	CHEMBL39	139	66	None	-2	27	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm801354e
	DB08839	139	66	None	-2	27	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm801354e
	4376990	192407	4	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5207529	192407	4	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222754	192407	4	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	4376990	192407	4	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5207529	192407	4	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222754	192407	4	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	5	139	66	None	-2	27	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/ml200206z
	5202	139	66	None	-2	27	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/ml200206z
	CHEMBL39	139	66	None	-2	27	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/ml200206z
	DB08839	139	66	None	-2	27	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/ml200206z
	5	139	66	None	-2	27	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm5019274
	5202	139	66	None	-2	27	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm5019274
	CHEMBL39	139	66	None	-2	27	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm5019274
	DB08839	139	66	None	-2	27	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm5019274
	439280	119514	104	None	-3	7	Human	9.0	pEC50	=	9	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	6971044	119514	104	None	-3	7	Human	9.0	pEC50	=	9	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	CHEMBL350221	119514	104	None	-3	7	Human	9.0	pEC50	=	9	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	5	139	66	None	-2	27	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	5202	139	66	None	-2	27	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	CHEMBL39	139	66	None	-2	27	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	DB08839	139	66	None	-2	27	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	5	139	66	None	-2	27	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	5202	139	66	None	-2	27	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	CHEMBL39	139	66	None	-2	27	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	DB08839	139	66	None	-2	27	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	439280	119514	104	None	-3	7	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	6971044	119514	104	None	-3	7	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	CHEMBL350221	119514	104	None	-3	7	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	168293874	191581	0	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5204071	191581	0	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	168293874	191581	0	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5204071	191581	0	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	5	139	66	None	-2	27	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5202	139	66	None	-2	27	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	CHEMBL39	139	66	None	-2	27	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	DB08839	139	66	None	-2	27	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5	139	66	None	-2	27	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5202	139	66	None	-2	27	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	CHEMBL39	139	66	None	-2	27	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	DB08839	139	66	None	-2	27	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5	139	66	None	-2	27	Human	8.8	pEC50	=	8.8	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	5202	139	66	None	-2	27	Human	8.8	pEC50	=	8.8	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	CHEMBL39	139	66	None	-2	27	Human	8.8	pEC50	=	8.8	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	DB08839	139	66	None	-2	27	Human	8.8	pEC50	=	8.8	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	166	3307	12	None	2	4	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm0709034
	3045227	3307	12	None	2	4	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm0709034
	CHEMBL76781	3307	12	None	2	4	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm0709034
	4407909	192264	1	None	1	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5182943	192264	1	None	1	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221893	192264	1	None	1	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	44315993	172308	0	None	2	3	Human	8.0	pEC50	=	8	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	222	3	1	3	2.1	CSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	CHEMBL451543	172308	0	None	2	3	Human	8.0	pEC50	=	8	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	222	3	1	3	2.1	CSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	4407909	192264	1	None	1	3	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5182943	192264	1	None	1	3	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221893	192264	1	None	1	3	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	16115269	137601	0	None	-1	3	Human	7.0	pEC50	=	7	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	CHEMBL376676	137601	0	None	-1	3	Human	7.0	pEC50	=	7	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	9881885	63778	0	None	-19	3	Human	7.0	pEC50	=	7	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL180815	63778	0	None	-19	3	Human	7.0	pEC50	=	7	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	17954204	63607	20	None	-81	3	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	181	0	1	1	2.0	Clc1ccc2c(c1)CCNCC2	10.1021/jm0709034
	CHEMBL180668	63607	20	None	-81	3	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	181	0	1	1	2.0	Clc1ccc2c(c1)CCNCC2	10.1021/jm0709034
	10465263	64001	55	None	-89	3	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	CC1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL181172	64001	55	None	-89	3	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	CC1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	11938	2379	5	None	-75	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5HT2bAgonist activity at human 5HT2b	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	146192952	2379	5	None	-75	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5HT2bAgonist activity at human 5HT2b	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	CHEMBL4468760	2379	5	None	-75	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5HT2bAgonist activity at human 5HT2b	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	59312249	111181	0	None	-8	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	282	3	2	4	2.4	CNc1nc(C(C)c2ccccc2)nc2c1CCNCC2	10.1021/jm5003292
	CHEMBL3286565	111181	0	None	-8	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	282	3	2	4	2.4	CNc1nc(C(C)c2ccccc2)nc2c1CCNCC2	10.1021/jm5003292
	122442324	137822	0	None	-12	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770174	137822	0	None	-12	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771386	137822	0	None	-12	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11658860	2312	47	None	-63	4	Human	6.0	pEC50	=	6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	2941	2312	47	None	-63	4	Human	6.0	pEC50	=	6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	4374	2312	47	None	-63	4	Human	6.0	pEC50	=	6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL360328	2312	47	None	-63	4	Human	6.0	pEC50	=	6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	DB04871	2312	47	None	-63	4	Human	6.0	pEC50	=	6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	10379910	62971	0	None	-6	2	Human	6.0	pEC50	=	6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	297	2	1	2	3.3	COc1cc2c(cc1Br)C(C(C)C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL179329	62971	0	None	-6	2	Human	6.0	pEC50	=	6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	297	2	1	2	3.3	COc1cc2c(cc1Br)C(C(C)C)CNCC2	10.1016/j.bmcl.2004.12.080
	17954204	63607	20	None	-81	3	Human	6.0	pEC50	=	6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	181	0	1	1	2.0	Clc1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL180668	63607	20	None	-81	3	Human	6.0	pEC50	=	6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	181	0	1	1	2.0	Clc1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2004.12.080
	122442324	137822	0	None	-12	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770174	137822	0	None	-12	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771386	137822	0	None	-12	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11493484	88641	0	None	-23	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337106	88641	0	None	-23	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365079	88641	0	None	-23	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	46230097	197685	0	None	-6	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	217	0	2	3	0.6	O=C1NC2CCNCCN2c2ccccc21	10.1016/j.bmcl.2009.12.014
	CHEMBL590816	197685	0	None	-6	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	217	0	2	3	0.6	O=C1NC2CCNCCN2c2ccccc21	10.1016/j.bmcl.2009.12.014
	122442251	137832	0	None	-15	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770225	137832	0	None	-15	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771396	137832	0	None	-15	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	4312735	192272	1	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5183950	192272	1	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221924	192272	1	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	4312735	192272	1	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5183950	192272	1	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221924	192272	1	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	122442251	137832	0	None	-15	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770225	137832	0	None	-15	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771396	137832	0	None	-15	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44573155	188570	0	None	6	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	280	4	2	3	1.1	O=S(=O)(NCC1CC1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL511044	188570	0	None	6	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	280	4	2	3	1.1	O=S(=O)(NCC1CC1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	168282202	192282	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5185430	192282	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221991	192282	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	168282202	192282	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5185430	192282	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221991	192282	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	44412404	77415	5	None	2	3	Human	7.0	pEC50	=	7.0	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	206	1	1	2	1.6	Fc1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	CHEMBL209106	77415	5	None	2	3	Human	7.0	pEC50	=	7.0	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	206	1	1	2	1.6	Fc1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	70693928	74136	0	None	-3	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	253	5	1	2	3.3	NC[C@H]1C[C@@H]1c1ccccc1OCc1ccccc1	10.1021/ml200206z
	CHEMBL2022192	74136	0	None	-3	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	253	5	1	2	3.3	NC[C@H]1C[C@@H]1c1ccccc1OCc1ccccc1	10.1021/ml200206z
	CHEMBL2028036	74136	0	None	-3	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	253	5	1	2	3.3	NC[C@H]1C[C@@H]1c1ccccc1OCc1ccccc1	10.1021/ml200206z
	162652937	183080	0	None	-67	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4751981	183080	0	None	-67	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802812	183080	0	None	-67	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	5	139	66	None	-2	27	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2009.07.063
	5202	139	66	None	-2	27	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2009.07.063
	CHEMBL39	139	66	None	-2	27	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2009.07.063
	DB08839	139	66	None	-2	27	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2009.07.063
	168	3919	11	None	3	5	Human	8.0	pEC50	=	8.0	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
	6604042	3919	11	None	3	5	Human	8.0	pEC50	=	8.0	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
	CHEMBL309760	3919	11	None	3	5	Human	8.0	pEC50	=	8.0	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
	157	2038	5	None	2	3	Rat	7.9	pEC50	=	7.9	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm050663x
	9840090	2038	5	None	2	3	Rat	7.9	pEC50	=	7.9	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm050663x
	CHEMBL134519	2038	5	None	2	3	Rat	7.9	pEC50	=	7.9	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm050663x
	157	2038	5	None	2	3	Rat	7.9	pEC50	=	7.9	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1016/j.bmcl.2007.03.073
	9840090	2038	5	None	2	3	Rat	7.9	pEC50	=	7.9	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1016/j.bmcl.2007.03.073
	CHEMBL134519	2038	5	None	2	3	Rat	7.9	pEC50	=	7.9	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1016/j.bmcl.2007.03.073
	10465263	64001	55	None	-89	3	Human	6.0	pEC50	=	6.0	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	CC1CNCCc2ccc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL181172	64001	55	None	-89	3	Human	6.0	pEC50	=	6.0	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	CC1CNCCc2ccc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	162652937	183080	0	None	-67	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4751981	183080	0	None	-67	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802812	183080	0	None	-67	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	134265627	163461	0	None	-602	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	297	2	1	3	2.5	Fc1cccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)c1	10.1021/acsmedchemlett.8b00328
	CHEMBL4208452	163461	0	None	-602	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	297	2	1	3	2.5	Fc1cccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)c1	10.1021/acsmedchemlett.8b00328
	53324327	56556	0	None	-1	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1cc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)ccn1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643857	56556	0	None	-1	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1cc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)ccn1	10.1016/j.bmcl.2010.11.089
	44572176	12453	0	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	2	1	1	2.8	Cc1ccc([C@H]2C[C@@H]2CN)c(Br)c1	10.1021/jm801354e
	CHEMBL1186735	12453	0	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	2	1	1	2.8	Cc1ccc([C@H]2C[C@@H]2CN)c(Br)c1	10.1021/jm801354e
	CHEMBL475641	12453	0	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	2	1	1	2.8	Cc1ccc([C@H]2C[C@@H]2CN)c(Br)c1	10.1021/jm801354e
	44572207	12593	0	None	-8	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	2	1	1	2.9	Cc1ccc(Cl)c([C@H]2C[C@@H]2CN)c1F	10.1021/jm801354e
	CHEMBL1187556	12593	0	None	-8	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	2	1	1	2.9	Cc1ccc(Cl)c([C@H]2C[C@@H]2CN)c1F	10.1021/jm801354e
	CHEMBL508680	12593	0	None	-8	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	2	1	1	2.9	Cc1ccc(Cl)c([C@H]2C[C@@H]2CN)c1F	10.1021/jm801354e
	11492162	71709	2	None	-11	3	Human	5.9	pEC50	=	5.9	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	206	3	1	1	2.4	CN(C)CCc1c[nH]c2cccc(F)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL197646	71709	2	None	-11	3	Human	5.9	pEC50	=	5.9	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	206	3	1	1	2.4	CN(C)CCc1c[nH]c2cccc(F)c12	10.1016/j.bmcl.2005.06.104
	53317924	56557	0	None	-6	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	406	4	1	7	1.7	CC(=O)N(C)c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643858	56557	0	None	-6	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	406	4	1	7	1.7	CC(=O)N(C)c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	44572180	12455	1	None	2	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1ccc([C@H]2C[C@@H]2CN)cc1C	10.1021/jm801354e
	CHEMBL1186737	12455	1	None	2	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1ccc([C@H]2C[C@@H]2CN)cc1C	10.1021/jm801354e
	CHEMBL475643	12455	1	None	2	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1ccc([C@H]2C[C@@H]2CN)cc1C	10.1021/jm801354e
	11151653	90670	0	None	-1	3	Human	7.9	pEC50	=	7.9	Functional	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	Cc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397896	90670	0	None	-1	3	Human	7.9	pEC50	=	7.9	Functional	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	Cc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	54587668	61130	0	None	-3	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1ccccc1Cc1ncc2c(n1)CCNCC2	10.1016/j.bmcl.2010.11.120
	CHEMBL1770378	61130	0	None	-3	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1ccccc1Cc1ncc2c(n1)CCNCC2	10.1016/j.bmcl.2010.11.120
	1355	1980	82	None	-5	6	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.063
	142	1980	82	None	-5	6	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.063
	CHEMBL478	1980	82	None	-5	6	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.063
	DB12110	1980	82	None	-5	6	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.063
	44573156	186714	0	None	-2	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	254	2	1	3	0.6	CN(C)S(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492949	186714	0	None	-2	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	254	2	1	3	0.6	CN(C)S(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	1355	1980	82	None	-5	6	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.136
	142	1980	82	None	-5	6	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.136
	CHEMBL478	1980	82	None	-5	6	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.136
	DB12110	1980	82	None	-5	6	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.136
	168285159	192312	0	None	1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5196522	192312	0	None	1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222172	192312	0	None	1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	23652278	62302	16	None	-83	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	C[C@@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL178365	62302	16	None	-83	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	C[C@@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	11608308	63978	3	None	-407	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	CHEMBL181076	63978	3	None	-407	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	162658803	183110	0	None	-14	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4759878	183110	0	None	-14	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803107	183110	0	None	-14	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	168285159	192312	0	None	1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5196522	192312	0	None	1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222172	192312	0	None	1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	162658803	183110	0	None	-14	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4759878	183110	0	None	-14	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803107	183110	0	None	-14	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	134265732	163255	0	None	-1000	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	285	2	1	3	2.3	FC(F)(F)CCc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4206126	163255	0	None	-1000	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	285	2	1	3	2.3	FC(F)(F)CCc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	134265665	164247	0	None	-1047	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	231	2	1	3	1.8	CCCc1cncc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4218374	164247	0	None	-1047	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	231	2	1	3	1.8	CCCc1cncc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	44572751	12393	1	None	-16	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
	CHEMBL1186509	12393	1	None	-16	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
	CHEMBL467736	12393	1	None	-16	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
	53321948	56510	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643677	56510	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	189	3436	31	None	-1	4	Human	7.9	pEC50	=	7.9	Functional	Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assay	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/acs.jmedchem.0c00424
	5163	3436	31	None	-1	4	Human	7.9	pEC50	=	7.9	Functional	Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assay	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/acs.jmedchem.0c00424
	CHEMBL297784	3436	31	None	-1	4	Human	7.9	pEC50	=	7.9	Functional	Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assay	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/acs.jmedchem.0c00424
	44431699	87861	0	None	5	2	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	315	4	1	6	1.7	Cc1noc(Cc2c3c(c(C[C@@H](C)N)c4c2OCC4)OCC3)n1	10.1016/j.bmcl.2007.03.073
	CHEMBL234837	87861	0	None	5	2	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	315	4	1	6	1.7	Cc1noc(Cc2c3c(c(C[C@@H](C)N)c4c2OCC4)OCC3)n1	10.1016/j.bmcl.2007.03.073
	10015414	63155	0	None	-32	3	Human	6.9	pEC50	=	6.9	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	259	1	1	2	3.0	COc1cc2c(cc1C(F)(F)F)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL179915	63155	0	None	-32	3	Human	6.9	pEC50	=	6.9	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	259	1	1	2	3.0	COc1cc2c(cc1C(F)(F)F)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	16115271	78698	0	None	-1	3	Human	7.9	pEC50	=	7.9	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	298	1	1	2	2.8	CC(C)[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	CHEMBL2113264	78698	0	None	-1	3	Human	7.9	pEC50	=	7.9	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	298	1	1	2	2.8	CC(C)[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	44572168	12378	1	None	-1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/jm801354e
	CHEMBL1186458	12378	1	None	-1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/jm801354e
	CHEMBL464475	12378	1	None	-1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/jm801354e
	10036629	64306	0	None	-9	3	Human	6.9	pEC50	=	6.9	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL181787	64306	0	None	-9	3	Human	6.9	pEC50	=	6.9	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	23652278	62302	16	None	-83	3	Human	5.9	pEC50	=	5.9	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	C[C@@H]1CNCCc2ccc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178365	62302	16	None	-83	3	Human	5.9	pEC50	=	5.9	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	C[C@@H]1CNCCc2ccc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	25084025	12592	1	None	-10	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1cccc(Br)c1	10.1021/jm801354e
	CHEMBL1187522	12592	1	None	-10	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1cccc(Br)c1	10.1021/jm801354e
	CHEMBL506727	12592	1	None	-10	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1cccc(Br)c1	10.1021/jm801354e
	45484687	196787	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	339	3	1	5	1.9	O=c1cc2c(nn1Cc1ccccc1OC(F)(F)F)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL577410	196787	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	339	3	1	5	1.9	O=c1cc2c(nn1Cc1ccccc1OC(F)(F)F)CCNCC2	10.1016/j.bmcl.2009.07.063
	53323196	56555	0	None	-23	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1cncc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643856	56555	0	None	-23	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1cncc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	118736623	118491	1	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	267	3	2	3	2.4	CNc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	CHEMBL3425755	118491	1	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	267	3	2	3	2.4	CNc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	118733808	120144	0	None	-1	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	CHEMBL3416056	120144	0	None	-1	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	CHEMBL3546908	120144	0	None	-1	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	44573231	186711	0	None	5	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	305	2	1	3	2.3	O=S(=O)(c1ccc(F)cc1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492911	186711	0	None	5	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	305	2	1	3	2.3	O=S(=O)(c1ccc(F)cc1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	216	2819	29	None	1	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/jm0709034
	9815618	2819	29	None	1	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/jm0709034
	CHEMBL253811	2819	29	None	1	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/jm0709034
	162653458	183084	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4753812	183084	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802839	183084	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	10331841	168638	6	None	-158	3	Human	5.8	pEC50	=	5.8	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	239	0	1	1	2.7	CC1CNCCc2ccc(Br)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL440752	168638	6	None	-158	3	Human	5.8	pEC50	=	5.8	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	239	0	1	1	2.7	CC1CNCCc2ccc(Br)cc21	10.1016/j.bmcl.2004.12.080
	44412389	77742	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	272	1	1	4	1.7	C[C@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL210215	77742	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	272	1	1	4	1.7	C[C@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1	10.1016/j.bmcl.2006.03.007
	162653458	183084	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4753812	183084	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802839	183084	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	11447552	62199	4	None	-239	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	CHEMBL178231	62199	4	None	-239	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	54585653	61136	0	None	1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	307	2	1	3	2.8	FC(F)(F)c1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770385	61136	0	None	1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	307	2	1	3	2.8	FC(F)(F)c1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	11427139	84263	0	None	-38	3	Human	5.8	pEC50	=	5.8	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	282	1	1	2	2.4	C=Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL222566	84263	0	None	-38	3	Human	5.8	pEC50	=	5.8	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	282	1	1	2	2.4	C=Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	53325937	56511	0	None	-53	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643678	56511	0	None	-53	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	25070581	61132	0	None	-1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770380	61132	0	None	-1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	134265616	163859	0	None	-1548	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	257	2	1	3	2.1	c1cc(CC2CCC2)c2c(n1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	CHEMBL4213447	163859	0	None	-1548	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	257	2	1	3	2.1	c1cc(CC2CCC2)c2c(n1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	122442286	137823	0	None	-34	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769987	137823	0	None	-34	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771387	137823	0	None	-34	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	118733798	120137	0	None	-12	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.3	C=C(F)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416051	120137	0	None	-12	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.3	C=C(F)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546894	120137	0	None	-12	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.3	C=C(F)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	44573220	186868	0	None	4	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	294	4	1	3	1.4	CN(CC1CC1)S(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL493951	186868	0	None	4	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	294	4	1	3	1.4	CN(CC1CC1)S(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	162658689	183108	0	None	-28	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4759181	183108	0	None	-28	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803103	183108	0	None	-28	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	122442272	137820	0	None	-54	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769968	137820	0	None	-54	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771384	137820	0	None	-54	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44572371	12421	0	None	-5	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1cccc(C#CCCCCO)c1	10.1021/jm801354e
	CHEMBL1186608	12421	0	None	-5	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1cccc(C#CCCCCO)c1	10.1021/jm801354e
	CHEMBL472678	12421	0	None	-5	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1cccc(C#CCCCCO)c1	10.1021/jm801354e
	162658689	183108	0	None	-28	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4759181	183108	0	None	-28	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803103	183108	0	None	-28	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	122442272	137820	0	None	-54	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769968	137820	0	None	-54	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771384	137820	0	None	-54	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	16115652	83078	0	None	-15	3	Human	6.8	pEC50	=	6.8	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	286	1	1	3	1.8	COc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL220211	83078	0	None	-15	3	Human	6.8	pEC50	=	6.8	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	286	1	1	3	1.8	COc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	54580776	61133	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1ccccc1Cc1ncc2c(n1)CCNCC2	10.1016/j.bmcl.2010.11.120
	CHEMBL1770381	61133	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1ccccc1Cc1ncc2c(n1)CCNCC2	10.1016/j.bmcl.2010.11.120
	118736624	118492	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	281	4	2	3	2.8	CCNc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	CHEMBL3425756	118492	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	281	4	2	3	2.8	CCNc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	44573229	172107	0	None	-2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	305	2	1	3	2.3	O=S(=O)(c1ccc2c(c1)CCNCC2)c1ccccc1F	10.1016/j.bmcl.2009.02.071
	CHEMBL449999	172107	0	None	-2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	305	2	1	3	2.3	O=S(=O)(c1ccc2c(c1)CCNCC2)c1ccccc1F	10.1016/j.bmcl.2009.02.071
	42601405	192053	0	None	-1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	287	2	1	3	2.2	O=S(=O)(c1ccccc1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL521805	192053	0	None	-1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	287	2	1	3	2.2	O=S(=O)(c1ccccc1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	11221167	84257	0	None	-25	3	Human	6.8	pEC50	=	6.8	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL222514	84257	0	None	-25	3	Human	6.8	pEC50	=	6.8	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	162657053	183099	0	None	-20	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4757214	183099	0	None	-20	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803017	183099	0	None	-20	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	10401602	122553	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	283	2	1	2	3.1	CCOc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL360968	122553	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	283	2	1	2	3.1	CCOc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	11447552	62199	4	None	-239	3	Human	5.8	pEC50	=	5.8	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2004.12.080
	CHEMBL178231	62199	4	None	-239	3	Human	5.8	pEC50	=	5.8	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2004.12.080
	25070907	61128	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770376	61128	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	44572369	12352	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	171	2	1	1	1.7	C#Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL1186108	12352	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	171	2	1	1	1.7	C#Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL450178	12352	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	171	2	1	1	1.7	C#Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	46228438	198302	0	None	-1862	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1OC1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL595195	198302	0	None	-1862	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1OC1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	45485742	196146	0	None	-18	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	318	5	1	5	2.2	Clc1ccccc1CCOc1cncc(N2CCNCC2)n1	10.1016/j.bmcl.2009.07.136
	CHEMBL572228	196146	0	None	-18	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	318	5	1	5	2.2	Clc1ccccc1CCOc1cncc(N2CCNCC2)n1	10.1016/j.bmcl.2009.07.136
	44412405	77428	0	None	2	3	Human	6.7	pEC50	=	6.7	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	255	1	1	1	3.4	FC(F)(F)c1cccc([C@H]2CC[C@H]3CNC[C@@H]23)c1	10.1016/j.bmcl.2006.03.007
	CHEMBL209155	77428	0	None	2	3	Human	6.7	pEC50	=	6.7	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	255	1	1	1	3.4	FC(F)(F)c1cccc([C@H]2CC[C@H]3CNC[C@@H]23)c1	10.1016/j.bmcl.2006.03.007
	11777150	62276	0	None	-63	3	Human	6.7	pEC50	=	6.7	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	255	0	2	2	2.4	CC1CNCCc2cc(O)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178313	62276	0	None	-63	3	Human	6.7	pEC50	=	6.7	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	255	0	2	2	2.4	CC1CNCCc2cc(O)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	11414184	83085	0	None	-7	3	Human	6.7	pEC50	=	6.7	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)C2CNCCN12	10.1021/jm0612968
	CHEMBL220274	83085	0	None	-7	3	Human	6.7	pEC50	=	6.7	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)C2CNCCN12	10.1021/jm0612968
	122442324	137822	0	None	-12	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770174	137822	0	None	-12	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771386	137822	0	None	-12	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442324	137822	0	None	-12	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770174	137822	0	None	-12	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771386	137822	0	None	-12	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44573216	186755	0	None	4	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	268	4	2	3	1.1	CCCNS(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL493151	186755	0	None	4	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	268	4	2	3	1.1	CCCNS(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	44572759	12356	1	None	-7	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL1186135	12356	1	None	-7	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL451368	12356	1	None	-7	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	24773650	154159	2	None	-3	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)CCNCC2C	10.1021/jm0709034
	CHEMBL399750	154159	2	None	-3	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)CCNCC2C	10.1021/jm0709034
	118733818	120153	0	None	-181	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416061	120153	0	None	-181	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546956	120153	0	None	-181	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	168294162	192409	0	None	1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5208129	192409	0	None	1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222770	192409	0	None	1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	10331841	168638	6	None	-158	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	239	0	1	1	2.7	CC1CNCCc2ccc(Br)cc21	10.1021/jm0709034
	CHEMBL440752	168638	6	None	-158	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	239	0	1	1	2.7	CC1CNCCc2ccc(Br)cc21	10.1021/jm0709034
	168294162	192409	0	None	1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5208129	192409	0	None	1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222770	192409	0	None	1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	135453290	133083	23	None	1	7	Rat	8.7	pEC50	=	8.7	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL371300	133083	23	None	1	7	Rat	8.7	pEC50	=	8.7	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	166	3307	12	None	2	4	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmc.2007.10.100
	3045227	3307	12	None	2	4	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmc.2007.10.100
	CHEMBL76781	3307	12	None	2	4	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmc.2007.10.100
	36906	104401	68	None	1	3	Rat	8.6	pEC50	=	8.6	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	204	3	2	2	2.1	COc1ccc2[nH]cc(CC(C)N)c2c1	10.1021/jm050663x
	CHEMBL31115	104401	68	None	1	3	Rat	8.6	pEC50	=	8.6	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	204	3	2	2	2.1	COc1ccc2[nH]cc(CC(C)N)c2c1	10.1021/jm050663x
	44572367	12436	0	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1ccccc1C#CCCCCO	10.1021/jm801354e
	CHEMBL1186673	12436	0	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1ccccc1C#CCCCCO	10.1021/jm801354e
	CHEMBL474230	12436	0	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1ccccc1C#CCCCCO	10.1021/jm801354e
	168291130	192374	0	None	2	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5201835	192374	0	None	2	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222548	192374	0	None	2	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	168291130	192374	0	None	2	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5201835	192374	0	None	2	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222548	192374	0	None	2	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	11290492	137474	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	218	1	1	3	0.8	COc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	CHEMBL376456	137474	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	218	1	1	3	0.8	COc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	11499800	88678	0	None	-10	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337503	88678	0	None	-10	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365465	88678	0	None	-10	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	122442254	137817	0	None	-26	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770963	137817	0	None	-26	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771381	137817	0	None	-26	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442254	137817	0	None	-26	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770963	137817	0	None	-26	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771381	137817	0	None	-26	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44572810	12546	2	None	-3	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
	CHEMBL1187196	12546	2	None	-3	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
	CHEMBL493130	12546	2	None	-3	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
	150	2473	18	None	-2	11	Human	7.7	pEC50	=	7.7	Functional	Agonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assayAgonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assay	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	1764	2473	18	None	-2	11	Human	7.7	pEC50	=	7.7	Functional	Agonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assayAgonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assay	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	8226	2473	18	None	-2	11	Human	7.7	pEC50	=	7.7	Functional	Agonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assayAgonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assay	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	CHEMBL1201356	2473	18	None	-2	11	Human	7.7	pEC50	=	7.7	Functional	Agonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assayAgonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assay	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	DB00353	2473	18	None	-2	11	Human	7.7	pEC50	=	7.7	Functional	Agonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assayAgonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assay	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	134265663	163127	0	None	-19	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	243	1	1	3	2.1	c1cc(C2CCC2)c2c(n1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	CHEMBL4204710	163127	0	None	-19	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	243	1	1	3	2.1	c1cc(C2CCC2)c2c(n1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	53317923	56552	0	None	-5	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643853	56552	0	None	-5	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	53325936	56508	0	None	-12	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	335	3	1	6	1.7	c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643675	56508	0	None	-12	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	335	3	1	6	1.7	c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	122442293	137814	0	None	-19	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3770599	137814	0	None	-19	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3771378	137814	0	None	-19	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	122442293	137814	0	None	-19	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3770599	137814	0	None	-19	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3771378	137814	0	None	-19	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	11658860	2312	47	None	-63	4	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	2941	2312	47	None	-63	4	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	4374	2312	47	None	-63	4	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	CHEMBL360328	2312	47	None	-63	4	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	DB04871	2312	47	None	-63	4	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	16115381	83030	0	None	1	3	Human	7.7	pEC50	=	7.7	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	CHEMBL219837	83030	0	None	1	3	Human	7.7	pEC50	=	7.7	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	44572166	12354	0	None	-7	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl	10.1021/jm801354e
	CHEMBL1186133	12354	0	None	-7	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl	10.1021/jm801354e
	CHEMBL451232	12354	0	None	-7	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl	10.1021/jm801354e
	118736626	118493	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	307	5	2	3	3.2	c1ccc(Cc2cc3c(c(NCC4CC4)n2)CCNCC3)cc1	10.1021/ml500507v
	CHEMBL3425758	118493	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	307	5	2	3	3.2	c1ccc(Cc2cc3c(c(NCC4CC4)n2)CCNCC3)cc1	10.1021/ml500507v
	18735305	203225	0	None	2	3	Human	7.7	pEC50	=	7.7	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	320	2	1	2	2.1	C[C@H](N)CN1CCc2cc(F)c(I)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL76301	203225	0	None	2	3	Human	7.7	pEC50	=	7.7	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	320	2	1	2	2.1	C[C@H](N)CN1CCc2cc(F)c(I)cc21	10.1016/j.bmcl.2003.05.001
	54583742	61127	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1ccccc1Cc1ncc2c(n1)CCNCC2	10.1016/j.bmcl.2010.11.120
	CHEMBL1770375	61127	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1ccccc1Cc1ncc2c(n1)CCNCC2	10.1016/j.bmcl.2010.11.120
	44389645	63850	0	None	-72	3	Human	6.7	pEC50	=	6.7	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL180867	63850	0	None	-72	3	Human	6.7	pEC50	=	6.7	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	118733790	120159	0	None	-36	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	2	3.0	C=CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416047	120159	0	None	-36	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	2	3.0	C=CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546973	120159	0	None	-36	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	2	3.0	C=CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	44572753	12594	3	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@@H]1C[C@H]1c1ccccc1Br	10.1021/jm801354e
	CHEMBL1187565	12594	3	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@@H]1C[C@H]1c1ccccc1Br	10.1021/jm801354e
	CHEMBL509418	12594	3	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@@H]1C[C@H]1c1ccccc1Br	10.1021/jm801354e
	53321947	56504	0	None	-2	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	257	1	1	5	1.0	c1cc2nc3c(c(N4CCCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	CHEMBL1643671	56504	0	None	-2	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	257	1	1	5	1.0	c1cc2nc3c(c(N4CCCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	44431701	87716	0	None	3	2	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	311	4	1	6	3.4	Cc1noc(Cc2c3ccoc3c(C[C@@H](C)N)c3ccoc23)n1	10.1016/j.bmcl.2007.03.073
	CHEMBL234682	87716	0	None	3	2	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	311	4	1	6	3.4	Cc1noc(Cc2c3ccoc3c(C[C@@H](C)N)c3ccoc23)n1	10.1016/j.bmcl.2007.03.073
	44409290	74302	0	None	-1	2	Human	7.6	pEC50	=	7.6	Functional	Efficacy against human recombinant 5HT2B receptor induced intracellular calcium mobilization in CHO cells by FLIPREfficacy against human recombinant 5HT2B receptor induced intracellular calcium mobilization in CHO cells by FLIPR	ChEMBL	273	4	1	4	1.7	C[C@@H]1CNC[C@H]2Cc3ccc(COCC4CC4)nc3N12	10.1016/j.bmcl.2005.11.083
	CHEMBL203013	74302	0	None	-1	2	Human	7.6	pEC50	=	7.6	Functional	Efficacy against human recombinant 5HT2B receptor induced intracellular calcium mobilization in CHO cells by FLIPREfficacy against human recombinant 5HT2B receptor induced intracellular calcium mobilization in CHO cells by FLIPR	ChEMBL	273	4	1	4	1.7	C[C@@H]1CNC[C@H]2Cc3ccc(COCC4CC4)nc3N12	10.1016/j.bmcl.2005.11.083
	10017556	161330	0	None	-3	3	Human	6.6	pEC50	=	6.6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	297	2	1	2	3.5	CC(C)Oc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL415029	161330	0	None	-3	3	Human	6.6	pEC50	=	6.6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	297	2	1	2	3.5	CC(C)Oc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	118733760	120126	1	None	-3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416032	120126	1	None	-3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546869	120126	1	None	-3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	11630623	88670	0	None	-213	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337499	88670	0	None	-213	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365399	88670	0	None	-213	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	58911653	90685	0	None	-25	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	244	1	1	2	1.5	CCc1cc(C)c2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397911	90685	0	None	-25	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	244	1	1	2	1.5	CCc1cc(C)c2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	168291896	192383	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5201903	192383	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222595	192383	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	145	140	48	None	-134	11	Rat	6.6	pEC50	=	6.6	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm050663x
	1832	140	48	None	-134	11	Rat	6.6	pEC50	=	6.6	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm050663x
	CHEMBL7257	140	48	None	-134	11	Rat	6.6	pEC50	=	6.6	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm050663x
	DB14010	140	48	None	-134	11	Rat	6.6	pEC50	=	6.6	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm050663x
	25070911	111180	0	None	-7	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	324	3	1	5	1.6	c1ccc(Cc2nc3c(c(N4CCOCC4)n2)CCNCC3)cc1	10.1021/jm5003292
	CHEMBL3286564	111180	0	None	-7	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	324	3	1	5	1.6	c1ccc(Cc2nc3c(c(N4CCOCC4)n2)CCNCC3)cc1	10.1021/jm5003292
	168291564	192381	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5201470	192381	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222574	192381	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	168291896	192383	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5201903	192383	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222595	192383	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	122442250	137816	0	None	-8	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770689	137816	0	None	-8	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771380	137816	0	None	-8	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	5	139	66	None	-2	27	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0709034
	5202	139	66	None	-2	27	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0709034
	CHEMBL39	139	66	None	-2	27	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0709034
	DB08839	139	66	None	-2	27	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0709034
	168291564	192381	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5201470	192381	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222574	192381	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	122442250	137816	0	None	-8	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770689	137816	0	None	-8	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771380	137816	0	None	-8	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	24773816	94415	0	None	-31	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	CHEMBL253805	94415	0	None	-31	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	24773814	94418	1	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	1	1	1	3.0	CC[C@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL253809	94418	1	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	1	1	1	3.0	CC[C@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	11264345	129877	5	None	-120	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	CC1CNCCc2ccc(Cl)c(F)c21	10.1021/jm0709034
	CHEMBL368016	129877	5	None	-120	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	CC1CNCCc2ccc(Cl)c(F)c21	10.1021/jm0709034
	122442300	137821	0	None	-8	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769421	137821	0	None	-8	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771385	137821	0	None	-8	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	122442300	137821	0	None	-8	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769421	137821	0	None	-8	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771385	137821	0	None	-8	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	146025684	183053	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4743977	183053	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802486	183053	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	162652983	183081	0	None	-12	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4752412	183081	0	None	-12	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802814	183081	0	None	-12	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	146025684	183053	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4743977	183053	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802486	183053	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	162652983	183081	0	None	-12	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4752412	183081	0	None	-12	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802814	183081	0	None	-12	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	45484673	197280	0	None	-8	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1ccc(Cl)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL585012	197280	0	None	-8	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1ccc(Cl)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	11595191	88631	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337488	88631	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2364960	88631	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	162658153	183103	0	None	-10	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4758641	183103	0	None	-10	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803076	183103	0	None	-10	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	162658153	183103	0	None	-10	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4758641	183103	0	None	-10	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803076	183103	0	None	-10	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	118736627	118494	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	295	5	2	3	3.2	CCCNc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	CHEMBL3425759	118494	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	295	5	2	3	3.2	CCCNc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	118736631	118497	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	238	2	1	2	2.4	c1ccc(Cc2cc3c(cn2)CCNCC3)cc1	10.1021/ml500507v
	CHEMBL3425763	118497	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	238	2	1	2	2.4	c1ccc(Cc2cc3c(cn2)CCNCC3)cc1	10.1021/ml500507v
	122442270	137818	1	None	-6	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770753	137818	1	None	-6	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771382	137818	1	None	-6	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442270	137818	1	None	-6	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770753	137818	1	None	-6	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771382	137818	1	None	-6	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11952353	198178	0	None	-1905	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	345	4	1	4	3.0	Fc1ccc(F)c(CO[C@H]2CCc3ccc(N4CCNCC4)nc32)c1	10.1016/j.bmcl.2009.10.112
	CHEMBL594469	198178	0	None	-1905	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	345	4	1	4	3.0	Fc1ccc(F)c(CO[C@H]2CCc3ccc(N4CCNCC4)nc32)c1	10.1016/j.bmcl.2009.10.112
	11171955	90662	0	None	-4	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.2	C[C@@H]1c2ccccc2C(=O)N2CCNC[C@@H]12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397888	90662	0	None	-4	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.2	C[C@@H]1c2ccccc2C(=O)N2CCNC[C@@H]12	10.1016/j.bmcl.2013.04.061
	44573002	12577	1	None	-19	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Br)cc1	10.1021/jm801354e
	CHEMBL1187408	12577	1	None	-19	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Br)cc1	10.1021/jm801354e
	CHEMBL501854	12577	1	None	-19	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Br)cc1	10.1021/jm801354e
	16115511	84413	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	250	1	1	2	2.0	CCc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL223466	84413	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	250	1	1	2	2.0	CCc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	162643473	183033	0	None	-14	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4777303	183033	0	None	-14	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802306	183033	0	None	-14	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	162643473	183033	0	None	-14	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4777303	183033	0	None	-14	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802306	183033	0	None	-14	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	11300712	141154	0	None	-2	3	Human	7.6	pEC50	=	7.6	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	252	1	1	3	1.4	COc1c(Cl)ccc2c1C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL385577	141154	0	None	-2	3	Human	7.6	pEC50	=	7.6	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	252	1	1	3	1.4	COc1c(Cl)ccc2c1C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	44573018	12535	1	None	-3	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)c(F)c1	10.1021/jm801354e
	CHEMBL1187169	12535	1	None	-3	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)c(F)c1	10.1021/jm801354e
	CHEMBL492306	12535	1	None	-3	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)c(F)c1	10.1021/jm801354e
	24826869	90671	0	None	-7	3	Human	7.6	pEC50	=	7.6	Functional	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	1	1	2	1.2	CCc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397897	90671	0	None	-7	3	Human	7.6	pEC50	=	7.6	Functional	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	1	1	2	1.2	CCc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	16115654	136450	0	None	-46	3	Human	6.6	pEC50	=	6.6	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.1	Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL374562	136450	0	None	-46	3	Human	6.6	pEC50	=	6.6	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.1	Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	53324629	56505	0	None	-4	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	271	1	1	5	1.4	c1cc2nc3c(c(N4CCCCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	CHEMBL1643672	56505	0	None	-4	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	271	1	1	5	1.4	c1cc2nc3c(c(N4CCCCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	1355	1980	82	None	-5	6	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	142	1980	82	None	-5	6	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	CHEMBL478	1980	82	None	-5	6	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	DB12110	1980	82	None	-5	6	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	1355	1980	82	None	-5	6	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	142	1980	82	None	-5	6	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	CHEMBL478	1980	82	None	-5	6	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	DB12110	1980	82	None	-5	6	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	46937339	73861	0	None	-13	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	235	5	1	2	2.7	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1	10.1021/ml200206z
	CHEMBL2023357	73861	0	None	-13	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	235	5	1	2	2.7	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1	10.1021/ml200206z
	46937339	73861	0	None	-13	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium mobilization	ChEMBL	235	5	1	2	2.7	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1	10.1021/jm5019274
	CHEMBL2023357	73861	0	None	-13	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium mobilization	ChEMBL	235	5	1	2	2.7	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1	10.1021/jm5019274
	16115392	84373	0	None	-5	2	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	236	0	1	2	1.7	Cc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL223292	84373	0	None	-5	2	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	236	0	1	2	1.7	Cc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	16115388	136841	0	None	-2	3	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	1	1	2	2.6	CC[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	CHEMBL375302	136841	0	None	-2	3	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	1	1	2	2.6	CC[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	11209786	136716	0	None	-208	3	Human	5.5	pEC50	=	5.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	296	1	1	2	2.7	O=C1c2c(cc(C3CC3)cc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL375170	136716	0	None	-208	3	Human	5.5	pEC50	=	5.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	296	1	1	2	2.7	O=C1c2c(cc(C3CC3)cc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	9859257	203413	0	None	1	3	Human	8.5	pEC50	=	8.5	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	218	2	1	3	1.3	C[C@H](N)CN1CCc2ccc3c(c21)CCO3	10.1016/j.bmcl.2003.05.001
	CHEMBL77880	203413	0	None	1	3	Human	8.5	pEC50	=	8.5	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	218	2	1	3	1.3	C[C@H](N)CN1CCc2ccc3c(c21)CCO3	10.1016/j.bmcl.2003.05.001
	168268877	189377	0	None	2	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5170784	189377	0	None	2	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	168268877	189377	0	None	2	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5170784	189377	0	None	2	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	230	4056	18	None	-3	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	243	3	1	4	2.7	CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C	10.1016/j.bmc.2007.10.100
	3045225	4056	18	None	-3	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	243	3	1	4	2.7	CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C	10.1016/j.bmc.2007.10.100
	CHEMBL407909	4056	18	None	-3	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	243	3	1	4	2.7	CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C	10.1016/j.bmc.2007.10.100
	5	139	66	None	-7	27	Rat	8.5	pEC50	=	8.5	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
	5202	139	66	None	-7	27	Rat	8.5	pEC50	=	8.5	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
	CHEMBL39	139	66	None	-7	27	Rat	8.5	pEC50	=	8.5	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
	DB08839	139	66	None	-7	27	Rat	8.5	pEC50	=	8.5	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
	44572798	12541	2	None	-1	3	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1cccc(F)c1	10.1021/jm801354e
	CHEMBL1187187	12541	2	None	-1	3	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1cccc(F)c1	10.1021/jm801354e
	CHEMBL492926	12541	2	None	-1	3	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1cccc(F)c1	10.1021/jm801354e
	46933845	15986	0	None	-18	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5HT2B receptor assessed as 5HT-induced calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor assessed as 5HT-induced calcium mobilization by FLIPR assay	ChEMBL	336	1	1	3	3.9	O=C(NC1CCCCC1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	CHEMBL1224034	15986	0	None	-18	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5HT2B receptor assessed as 5HT-induced calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor assessed as 5HT-induced calcium mobilization by FLIPR assay	ChEMBL	336	1	1	3	3.9	O=C(NC1CCCCC1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	54583743	61134	0	None	5	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770382	61134	0	None	5	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	118736630	118496	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	281	3	1	3	2.4	CN(C)c1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	CHEMBL3425762	118496	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	281	3	1	3	2.4	CN(C)c1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	122442263	137829	0	None	-30	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769454	137829	0	None	-30	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771393	137829	0	None	-30	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44389646	64552	0	None	-6	3	Human	7.5	pEC50	=	7.5	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)[C@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL182184	64552	0	None	-6	3	Human	7.5	pEC50	=	7.5	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)[C@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	122442263	137829	0	None	-30	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769454	137829	0	None	-30	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771393	137829	0	None	-30	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442260	137826	0	None	-2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769543	137826	0	None	-2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771390	137826	0	None	-2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11949712	200475	0	None	-3019	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1O[C@H]1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL609306	200475	0	None	-3019	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1O[C@H]1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	118733764	120133	0	None	-2	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416034	120133	0	None	-2	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546890	120133	0	None	-2	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	118733776	120139	0	None	-2	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	CHEMBL3416040	120139	0	None	-2	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	CHEMBL3546903	120139	0	None	-2	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	70687695	74129	0	None	-12	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	205	5	1	2	2.5	CCCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2022186	74129	0	None	-12	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	205	5	1	2	2.5	CCCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2027987	74129	0	None	-12	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	205	5	1	2	2.5	CCCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	134265675	163815	0	None	-40	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	297	2	1	3	2.5	Fc1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1	10.1021/acsmedchemlett.8b00328
	CHEMBL4212834	163815	0	None	-40	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	297	2	1	3	2.5	Fc1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1	10.1021/acsmedchemlett.8b00328
	162645074	183042	0	None	-20	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4740346	183042	0	None	-20	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802388	183042	0	None	-20	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	162645074	183042	0	None	-20	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4740346	183042	0	None	-20	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802388	183042	0	None	-20	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	11400855	12348	6	None	-3	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@@H]1C[C@H]1c1ccccc1	10.1021/jm801354e
	CHEMBL1186092	12348	6	None	-3	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@@H]1C[C@H]1c1ccccc1	10.1021/jm801354e
	CHEMBL449134	12348	6	None	-3	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@@H]1C[C@H]1c1ccccc1	10.1021/jm801354e
	57799306	88680	0	None	-12	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337493	88680	0	None	-12	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365469	88680	0	None	-12	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
	122442260	137826	0	None	-2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769543	137826	0	None	-2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771390	137826	0	None	-2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44315697	203794	0	None	-1	3	Human	7.5	pEC50	=	7.5	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	4	1	3	2.6	CCSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	CHEMBL80731	203794	0	None	-1	3	Human	7.5	pEC50	=	7.5	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	4	1	3	2.6	CCSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	168268736	192187	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5177718	192187	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221369	192187	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	9990808	122257	0	None	-51	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	CC1CNCCc2cc(F)c(Cl)cc21	10.1021/jm0709034
	CHEMBL360492	122257	0	None	-51	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	CC1CNCCc2cc(F)c(Cl)cc21	10.1021/jm0709034
	168268736	192187	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5177718	192187	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221369	192187	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	11652452	88697	0	None	-9	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	270	0	1	2	1.8	CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337492	88697	0	None	-9	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	270	0	1	2	1.8	CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365703	88697	0	None	-9	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	270	0	1	2	1.8	CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21	10.1016/j.bmcl.2012.10.091
	44572749	12331	1	None	-6	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccccc1Cl	10.1021/jm801354e
	CHEMBL1185954	12331	1	None	-6	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccccc1Cl	10.1021/jm801354e
	CHEMBL443128	12331	1	None	-6	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccccc1Cl	10.1021/jm801354e
	44412150	77380	0	None	-1	3	Human	6.5	pEC50	=	6.5	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CCC3CNCC32)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL208936	77380	0	None	-1	3	Human	6.5	pEC50	=	6.5	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CCC3CNCC32)n1	10.1016/j.bmcl.2006.03.007
	11658860	2312	47	None	-63	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	2941	2312	47	None	-63	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	4374	2312	47	None	-63	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	CHEMBL360328	2312	47	None	-63	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	DB04871	2312	47	None	-63	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	122442250	137816	0	None	-8	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770689	137816	0	None	-8	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771380	137816	0	None	-8	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	16115644	136437	0	None	-1	3	Human	7.5	pEC50	=	7.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.4	CCc1cc2c(cc1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL374436	136437	0	None	-1	3	Human	7.5	pEC50	=	7.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.4	CCc1cc2c(cc1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	118736628	118495	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	295	4	2	3	3.2	CC(C)Nc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	CHEMBL3425760	118495	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	295	4	2	3	3.2	CC(C)Nc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	44573230	186710	0	None	-3	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	305	2	1	3	2.3	O=S(=O)(c1cccc(F)c1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492910	186710	0	None	-3	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	305	2	1	3	2.3	O=S(=O)(c1cccc(F)c1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	3356430	192444	2	None	2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5208864	192444	2	None	2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222941	192444	2	None	2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	70683433	74109	1	None	-18	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	191	4	1	2	2.1	CCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2022185	74109	1	None	-18	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	191	4	1	2	2.1	CCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2027895	74109	1	None	-18	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	191	4	1	2	2.1	CCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	122442250	137816	0	None	-8	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770689	137816	0	None	-8	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771380	137816	0	None	-8	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442266	137815	0	None	-51	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769499	137815	0	None	-51	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771379	137815	0	None	-51	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442266	137815	0	None	-51	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769499	137815	0	None	-51	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771379	137815	0	None	-51	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44573016	12561	1	None	-38	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1c(F)cccc1F	10.1021/jm801354e
	CHEMBL1187322	12561	1	None	-38	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1c(F)cccc1F	10.1021/jm801354e
	CHEMBL498863	12561	1	None	-38	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1c(F)cccc1F	10.1021/jm801354e
	168272608	192191	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5177484	192191	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221391	192191	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	162657053	183099	0	None	-20	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4757214	183099	0	None	-20	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803017	183099	0	None	-20	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	168272608	192191	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5177484	192191	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221391	192191	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	3356430	192444	2	None	2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5208864	192444	2	None	2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222941	192444	2	None	2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	44573222	173740	0	None	2	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	294	2	1	3	1.5	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCCCC1	10.1016/j.bmcl.2009.02.071
	CHEMBL455039	173740	0	None	2	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	294	2	1	3	1.5	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCCCC1	10.1016/j.bmcl.2009.02.071
	118733766	120127	0	None	-33	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416035	120127	0	None	-33	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546870	120127	0	None	-33	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	146025686	183177	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4790992	183177	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803813	183177	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	146025686	183177	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4790992	183177	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803813	183177	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	44572757	12540	1	None	-7	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1ccccc1C(F)(F)F	10.1021/jm801354e
	CHEMBL1187186	12540	1	None	-7	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1ccccc1C(F)(F)F	10.1021/jm801354e
	CHEMBL492917	12540	1	None	-7	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1ccccc1C(F)(F)F	10.1021/jm801354e
	45484742	196841	0	None	-1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	243	3	2	3	1.7	c1ccc(COc2n[nH]c3c2CCNCC3)cc1	10.1016/j.bmcl.2009.07.063
	CHEMBL577903	196841	0	None	-1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	243	3	2	3	1.7	c1ccc(COc2n[nH]c3c2CCNCC3)cc1	10.1016/j.bmcl.2009.07.063
	122442286	137823	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769987	137823	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771387	137823	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442286	137823	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769987	137823	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771387	137823	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44573221	192478	0	None	-7	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	280	2	1	3	1.2	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCCC1	10.1016/j.bmcl.2009.02.071
	CHEMBL522514	192478	0	None	-7	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	280	2	1	3	1.2	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCCC1	10.1016/j.bmcl.2009.02.071
	44622848	192744	0	None	-11	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	255	2	1	4	1.0	O=c1cc2c(nn1Cc1ccccc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL524778	192744	0	None	-11	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	255	2	1	4	1.0	O=c1cc2c(nn1Cc1ccccc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	9881119	203762	0	None	-1	3	Human	7.4	pEC50	=	7.4	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	232	2	1	3	1.7	C[C@H](N)CN1CCc2ccc3c(c21)CCCO3	10.1016/j.bmcl.2003.05.001
	CHEMBL80482	203762	0	None	-1	3	Human	7.4	pEC50	=	7.4	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	232	2	1	3	1.7	C[C@H](N)CN1CCc2ccc3c(c21)CCCO3	10.1016/j.bmcl.2003.05.001
	9990808	122257	0	None	-51	3	Human	6.4	pEC50	=	6.4	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	213	0	1	1	2.7	CC1CNCCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL360492	122257	0	None	-51	3	Human	6.4	pEC50	=	6.4	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	213	0	1	1	2.7	CC1CNCCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2004.12.080
	44573012	12534	0	None	-3	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1cccc(F)c1F	10.1021/jm801354e
	CHEMBL1187168	12534	0	None	-3	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1cccc(F)c1F	10.1021/jm801354e
	CHEMBL492305	12534	0	None	-3	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1cccc(F)c1F	10.1021/jm801354e
	11206703	90661	0	None	-12	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	C[C@@H]1CNC[C@H]2Cc3ccccc3C(=O)N12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397887	90661	0	None	-12	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	C[C@@H]1CNC[C@H]2Cc3ccccc3C(=O)N12	10.1016/j.bmcl.2013.04.061
	44572657	12361	5	None	-7	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@H]1C[C@@H]1c1ccccc1	10.1021/jm801354e
	CHEMBL1186169	12361	5	None	-7	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@H]1C[C@@H]1c1ccccc1	10.1021/jm801354e
	CHEMBL452719	12361	5	None	-7	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@H]1C[C@@H]1c1ccccc1	10.1021/jm801354e
	44573004	12414	1	None	3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccc([C@H]2C[C@@H]2CN)cc1	10.1021/jm801354e
	CHEMBL1186590	12414	1	None	3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccc([C@H]2C[C@@H]2CN)cc1	10.1021/jm801354e
	CHEMBL471202	12414	1	None	3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccc([C@H]2C[C@@H]2CN)cc1	10.1021/jm801354e
	53325938	56512	0	None	-4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1ccccc1OC1CN(c2c3c(nc4ccnn24)CCNCC3)C1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643679	56512	0	None	-4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1ccccc1OC1CN(c2c3c(nc4ccnn24)CCNCC3)C1	10.1016/j.bmcl.2010.11.089
	10105208	62170	0	None	-83	3	Human	6.4	pEC50	=	6.4	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.0	CC1CNCCc2ccc(C(F)(F)F)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178124	62170	0	None	-83	3	Human	6.4	pEC50	=	6.4	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.0	CC1CNCCc2ccc(C(F)(F)F)cc21	10.1016/j.bmcl.2004.12.080
	1355	1980	82	None	-5	6	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0709034
	142	1980	82	None	-5	6	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0709034
	CHEMBL478	1980	82	None	-5	6	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0709034
	DB12110	1980	82	None	-5	6	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0709034
	24773649	94386	0	None	-10	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@H]1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	CHEMBL253591	94386	0	None	-10	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@H]1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	24773651	154318	0	None	-6	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)[C@H](C)CNCC2	10.1021/jm0709034
	CHEMBL400600	154318	0	None	-6	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)[C@H](C)CNCC2	10.1021/jm0709034
	46228437	198301	0	None	-39	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	343	3	1	4	3.6	Clc1ccccc1O[C@H]1CCCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL595194	198301	0	None	-39	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	343	3	1	4	3.6	Clc1ccccc1O[C@H]1CCCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	24773895	94416	0	None	-50	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)[C@@H](C)CNCC2	10.1021/jm0709034
	CHEMBL253806	94416	0	None	-50	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)[C@@H](C)CNCC2	10.1021/jm0709034
	122442270	137818	1	None	-6	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770753	137818	1	None	-6	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771382	137818	1	None	-6	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	24773979	129647	17	None	-12	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	161	0	1	1	1.9	CC1CNCCc2ccccc21	10.1021/jm0709034
	CHEMBL367796	129647	17	None	-12	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	161	0	1	1	1.9	CC1CNCCc2ccccc21	10.1021/jm0709034
	11264955	203253	0	None	1	3	Human	8.4	pEC50	=	8.4	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	240	3	1	3	2.3	CSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	CHEMBL76474	203253	0	None	1	3	Human	8.4	pEC50	=	8.4	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	240	3	1	3	2.3	CSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	152	361	18	None	-2	5	Rat	8.4	pEC50	=	8.4	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm050663x
	2107	361	18	None	-2	5	Rat	8.4	pEC50	=	8.4	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm050663x
	CHEMBL275854	361	18	None	-2	5	Rat	8.4	pEC50	=	8.4	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm050663x
	11708275	72367	3	None	1	2	Rat	8.4	pEC50	=	8.4	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	205	3	1	4	1.4	COc1ccc2cnn(C[C@H](C)N)c2c1	10.1021/jm050663x
	CHEMBL199775	72367	3	None	1	2	Rat	8.4	pEC50	=	8.4	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	205	3	1	4	1.4	COc1ccc2cnn(C[C@H](C)N)c2c1	10.1021/jm050663x
	166	3307	12	None	2	4	Human	8.4	pEC50	=	8.4	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
	3045227	3307	12	None	2	4	Human	8.4	pEC50	=	8.4	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
	CHEMBL76781	3307	12	None	2	4	Human	8.4	pEC50	=	8.4	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
	5	139	66	None	-2	27	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF methodAgonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2018.01.002
	5202	139	66	None	-2	27	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF methodAgonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2018.01.002
	CHEMBL39	139	66	None	-2	27	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF methodAgonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2018.01.002
	DB08839	139	66	None	-2	27	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF methodAgonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2018.01.002
	16047544	12539	7	None	-3	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NCC1CC1c1ccccc1Br	10.1021/jm801354e
	CHEMBL1187185	12539	7	None	-3	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NCC1CC1c1ccccc1Br	10.1021/jm801354e
	CHEMBL492916	12539	7	None	-3	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NCC1CC1c1ccccc1Br	10.1021/jm801354e
	44572172	12439	0	None	1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	179	2	1	1	2.2	Cc1cc([C@H]2C[C@@H]2CN)ccc1F	10.1021/jm801354e
	CHEMBL1186686	12439	0	None	1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	179	2	1	1	2.2	Cc1cc([C@H]2C[C@@H]2CN)ccc1F	10.1021/jm801354e
	CHEMBL474633	12439	0	None	1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	179	2	1	1	2.2	Cc1cc([C@H]2C[C@@H]2CN)ccc1F	10.1021/jm801354e
	16115267	84369	0	None	-2	3	Human	7.4	pEC50	=	7.4	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	CHEMBL223272	84369	0	None	-2	3	Human	7.4	pEC50	=	7.4	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	9994008	165596	0	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	283	2	1	2	3.1	CCC1CNCCc2cc(OC)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL426235	165596	0	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	283	2	1	2	3.1	CCC1CNCCc2cc(OC)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	122442270	137818	1	None	-6	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770753	137818	1	None	-6	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771382	137818	1	None	-6	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	22368315	63435	0	None	-50	3	Human	6.4	pEC50	=	6.4	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	255	1	1	2	2.1	COc1cc2c(cc1Br)CCNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL180166	63435	0	None	-50	3	Human	6.4	pEC50	=	6.4	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	255	1	1	2	2.1	COc1cc2c(cc1Br)CCNCC2	10.1016/j.bmcl.2004.12.080
	134265618	163503	0	None	-323	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	257	2	1	3	2.1	c1cc(CC2CCC2)c2c(n1)N1CCNCC1CC2	10.1021/acsmedchemlett.8b00328
	CHEMBL4209052	163503	0	None	-323	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	257	2	1	3	2.1	c1cc(CC2CCC2)c2c(n1)N1CCNCC1CC2	10.1021/acsmedchemlett.8b00328
	46884138	8358	0	None	-812	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at 5HT2B receptorAgonist activity at 5HT2B receptor	ChEMBL	364	7	2	4	3.2	COc1cc(OCC2CCCCC2)c(F)cc1CNC(=O)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	CHEMBL1093699	8358	0	None	-812	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at 5HT2B receptorAgonist activity at 5HT2B receptor	ChEMBL	364	7	2	4	3.2	COc1cc(OCC2CCCCC2)c(F)cc1CNC(=O)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	44572812	12408	1	None	-5	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1	10.1021/jm801354e
	CHEMBL1186561	12408	1	None	-5	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1	10.1021/jm801354e
	CHEMBL469729	12408	1	None	-5	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1	10.1021/jm801354e
	54587669	61131	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770379	61131	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	11609026	88698	0	None	-125	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337500	88698	0	None	-125	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365705	88698	0	None	-125	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
	44573014	12415	1	None	-10	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)cc1F	10.1021/jm801354e
	CHEMBL1186595	12415	1	None	-10	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)cc1F	10.1021/jm801354e
	CHEMBL471802	12415	1	None	-10	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)cc1F	10.1021/jm801354e
	3568128	192331	1	None	4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5195443	192331	1	None	4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222291	192331	1	None	4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	3568128	192331	1	None	4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5195443	192331	1	None	4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222291	192331	1	None	4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	44420682	137083	0	None	-1	3	Human	6.4	pEC50	=	6.4	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	0	2	2.1	CN1CCN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2C1	10.1021/jm0612968
	CHEMBL375642	137083	0	None	-1	3	Human	6.4	pEC50	=	6.4	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	0	2	2.1	CN1CCN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2C1	10.1021/jm0612968
	118733802	120141	0	None	-1	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416053	120141	0	None	-1	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546905	120141	0	None	-1	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	168284548	192309	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	1	3	2	4.1	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5191889	192309	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	1	3	2	4.1	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222143	192309	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	1	3	2	4.1	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	168284548	192309	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	1	3	2	4.1	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5191889	192309	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	1	3	2	4.1	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222143	192309	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	1	3	2	4.1	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	118733788	120152	0	None	-5	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	2	3.0	C=CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416046	120152	0	None	-5	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	2	3.0	C=CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546955	120152	0	None	-5	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	2	3.0	C=CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	11658860	2312	47	None	-63	4	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	2941	2312	47	None	-63	4	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	4374	2312	47	None	-63	4	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	CHEMBL360328	2312	47	None	-63	4	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	DB04871	2312	47	None	-63	4	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	146025689	183135	0	None	-17	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4781163	183135	0	None	-17	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803350	183135	0	None	-17	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	11658860	2312	47	None	-63	4	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	2941	2312	47	None	-63	4	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	4374	2312	47	None	-63	4	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	CHEMBL360328	2312	47	None	-63	4	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	DB04871	2312	47	None	-63	4	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	146025689	183135	0	None	-17	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4781163	183135	0	None	-17	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803350	183135	0	None	-17	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	118733792	120160	0	None	-12	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416048	120160	0	None	-12	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546974	120160	0	None	-12	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	162659286	183113	0	None	-13	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4762225	183113	0	None	-13	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803142	183113	0	None	-13	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	122442266	137815	0	None	-51	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769499	137815	0	None	-51	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771379	137815	0	None	-51	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442266	137815	0	None	-51	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769499	137815	0	None	-51	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771379	137815	0	None	-51	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	162659286	183113	0	None	-13	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4762225	183113	0	None	-13	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803142	183113	0	None	-13	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	146025687	183133	0	None	-25	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4779260	183133	0	None	-25	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803306	183133	0	None	-25	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	118733804	120142	0	None	-4	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	CHEMBL3416054	120142	0	None	-4	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	CHEMBL3546906	120142	0	None	-4	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	162668367	183157	0	None	-21	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4786831	183157	0	None	-21	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803642	183157	0	None	-21	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	122442309	137819	0	None	-6	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769828	137819	0	None	-6	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771383	137819	0	None	-6	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	168294156	192403	0	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5207023	192403	0	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222736	192403	0	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	162668367	183157	0	None	-21	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4786831	183157	0	None	-21	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803642	183157	0	None	-21	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	168294156	192403	0	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5207023	192403	0	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222736	192403	0	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	122442254	137817	0	None	-26	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770963	137817	0	None	-26	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771381	137817	0	None	-26	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442309	137819	0	None	-6	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769828	137819	0	None	-6	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771383	137819	0	None	-6	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	44572164	12574	0	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1F	10.1021/jm801354e
	CHEMBL1187390	12574	0	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1F	10.1021/jm801354e
	CHEMBL501526	12574	0	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1F	10.1021/jm801354e
	146025687	183133	0	None	-25	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4779260	183133	0	None	-25	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803306	183133	0	None	-25	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	46230099	197632	0	None	-25	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	251	0	2	3	1.2	O=C1NC2CCNCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
	CHEMBL590483	197632	0	None	-25	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	251	0	2	3	1.2	O=C1NC2CCNCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
	118733794	120161	0	None	-72	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416049	120161	0	None	-72	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546975	120161	0	None	-72	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	122442254	137817	0	None	-26	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770963	137817	0	None	-26	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771381	137817	0	None	-26	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442286	137823	0	None	-34	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769987	137823	0	None	-34	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771387	137823	0	None	-34	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	45484682	196694	0	None	-3	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	323	2	1	4	2.0	O=c1cc2c(nn1Cc1ccc(C(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL576651	196694	0	None	-3	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	323	2	1	4	2.0	O=c1cc2c(nn1Cc1ccc(C(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	11658860	2312	47	None	-63	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	2941	2312	47	None	-63	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	4374	2312	47	None	-63	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	CHEMBL360328	2312	47	None	-63	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	DB04871	2312	47	None	-63	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	44573153	186614	0	None	1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	336	3	2	3	2.8	O=S(=O)(Nc1ccccc1Cl)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492348	186614	0	None	1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	336	3	2	3	2.8	O=S(=O)(Nc1ccccc1Cl)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	44573157	186715	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	316	3	1	3	2.2	CN(c1ccccc1)S(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492950	186715	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	316	3	1	3	2.2	CN(c1ccccc1)S(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	134265622	164201	0	None	-81	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	259	1	1	3	2.4	CC(C)(C)Cc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4217787	164201	0	None	-81	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	259	1	1	3	2.4	CC(C)(C)Cc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	44412388	77820	0	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	272	1	1	4	1.7	C[C@@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL210484	77820	0	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	272	1	1	4	1.7	C[C@@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1	10.1016/j.bmcl.2006.03.007
	145966293	163902	0	None	-14	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	267	0	1	3	1.6	Brc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4213971	163902	0	None	-14	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	267	0	1	3	1.6	Brc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	18735309	203722	0	None	2	3	Human	7.3	pEC50	=	7.3	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	262	2	1	2	2.6	C[C@H](N)CN1CCc2cc(F)c(C(F)(F)F)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL80246	203722	0	None	2	3	Human	7.3	pEC50	=	7.3	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	262	2	1	2	2.6	C[C@H](N)CN1CCc2cc(F)c(C(F)(F)F)cc21	10.1016/j.bmcl.2003.05.001
	118733814	120146	0	None	-23	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	CHEMBL3416059	120146	0	None	-23	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	CHEMBL3546910	120146	0	None	-23	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	44572761	12571	0	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1ccccc1O	10.1021/jm801354e
	CHEMBL1187377	12571	0	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1ccccc1O	10.1021/jm801354e
	CHEMBL501117	12571	0	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1ccccc1O	10.1021/jm801354e
	11302765	83832	2	None	-309	3	Human	5.3	pEC50	=	5.3	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL221113	83832	2	None	-309	3	Human	5.3	pEC50	=	5.3	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	11448649	83020	0	None	-19	3	Human	6.3	pEC50	=	6.3	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	272	1	1	3	1.7	O=C1c2c(OC(F)(F)F)cccc2C2CNCCN12	10.1021/jm0612968
	CHEMBL219734	83020	0	None	-19	3	Human	6.3	pEC50	=	6.3	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	272	1	1	3	1.7	O=C1c2c(OC(F)(F)F)cccc2C2CNCCN12	10.1021/jm0612968
	50878551	90314	60	None	1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	CHEMBL2391541	90314	60	None	1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	50878551	90314	60	None	1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	CHEMBL2391541	90314	60	None	1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	44572808	12597	0	None	-1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1cccc(O)c1	10.1021/jm801354e
	CHEMBL1187585	12597	0	None	-1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1cccc(O)c1	10.1021/jm801354e
	CHEMBL510383	12597	0	None	-1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1cccc(O)c1	10.1021/jm801354e
	44431688	152208	0	None	1	2	Rat	8.2	pEC50	=	8.2	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	307	7	1	5	1.6	COCCOCc1c2c(c(C[C@@H](C)N)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	CHEMBL397321	152208	0	None	1	2	Rat	8.2	pEC50	=	8.2	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	307	7	1	5	1.6	COCCOCc1c2c(c(C[C@@H](C)N)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	5	139	66	None	-2	27	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.10.100
	5202	139	66	None	-2	27	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.10.100
	CHEMBL39	139	66	None	-2	27	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.10.100
	DB08839	139	66	None	-2	27	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.10.100
	135509961	135609	2	None	-1	2	Rat	8.2	pEC50	=	8.2	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	225	2	2	4	1.7	C[C@H](N)Cn1ncc2ccc(O)c(Cl)c21	10.1021/jm050663x
	CHEMBL373245	135609	2	None	-1	2	Rat	8.2	pEC50	=	8.2	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	225	2	2	4	1.7	C[C@H](N)Cn1ncc2ccc(O)c(Cl)c21	10.1021/jm050663x
	9991444	62303	0	None	-15	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	CHEMBL178366	62303	0	None	-15	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	154699445	176852	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Antagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assayAntagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assay	ChEMBL	319	4	0	4	4.2	CCP(=O)(OC)c1ccc2oc(-c3ccc(F)cc3)nc2c1	10.1021/acs.jmedchem.0c00807
	CHEMBL4638592	176852	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Antagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assayAntagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assay	ChEMBL	319	4	0	4	4.2	CCP(=O)(OC)c1ccc2oc(-c3ccc(F)cc3)nc2c1	10.1021/acs.jmedchem.0c00807
	11737032	84592	0	None	-13	3	Human	6.3	pEC50	=	6.3	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	222	0	1	2	1.4	O=C1c2c(Cl)cccc2C2CNCCN12	10.1021/jm0612968
	CHEMBL223896	84592	0	None	-13	3	Human	6.3	pEC50	=	6.3	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	222	0	1	2	1.4	O=C1c2c(Cl)cccc2C2CNCCN12	10.1021/jm0612968
	162674022	182639	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assay	ChEMBL	305	4	1	4	3.5	N#Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
	CHEMBL4796102	182639	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assay	ChEMBL	305	4	1	4	3.5	N#Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
	22292784	64263	12	None	-17	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	CC1CNCCc2cc(Cl)ccc21	10.1021/jm0709034
	CHEMBL181672	64263	12	None	-17	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	CC1CNCCc2cc(Cl)ccc21	10.1021/jm0709034
	24773809	94441	0	None	-63	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	C[C@H]1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	CHEMBL254009	94441	0	None	-63	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	C[C@H]1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	122442300	137821	0	None	-8	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769421	137821	0	None	-8	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771385	137821	0	None	-8	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	24773900	122916	8	None	-6	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)C(C)CNCC2	10.1021/jm0709034
	CHEMBL361742	122916	8	None	-6	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)C(C)CNCC2	10.1021/jm0709034
	118733778	120148	0	None	-19	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	CHEMBL3416041	120148	0	None	-19	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	CHEMBL3546951	120148	0	None	-19	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	50942111	56553	0	None	-5	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643854	56553	0	None	-5	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	45485725	196150	0	None	-19	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	348	5	1	6	1.9	C[C@@H](COc1ccccc1Cl)n1nc(N2CCNCC2)ccc1=O	10.1016/j.bmcl.2009.07.136
	CHEMBL572252	196150	0	None	-19	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	348	5	1	6	1.9	C[C@@H](COc1ccccc1Cl)n1nc(N2CCNCC2)ccc1=O	10.1016/j.bmcl.2009.07.136
	122442300	137821	0	None	-8	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769421	137821	0	None	-8	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771385	137821	0	None	-8	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	44572698	12445	0	None	5	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	197	2	1	1	2.9	NC[C@H]1C[C@@H]1c1ccc2ccccc2c1	10.1021/jm801354e
	CHEMBL1186700	12445	0	None	5	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	197	2	1	1	2.9	NC[C@H]1C[C@@H]1c1ccc2ccccc2c1	10.1021/jm801354e
	CHEMBL474885	12445	0	None	5	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	197	2	1	1	2.9	NC[C@H]1C[C@@H]1c1ccc2ccccc2c1	10.1021/jm801354e
	162652562	183075	0	None	-4	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4752604	183075	0	None	-4	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4802785	183075	0	None	-4	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	11658860	2312	47	None	-63	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	2941	2312	47	None	-63	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	4374	2312	47	None	-63	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	CHEMBL360328	2312	47	None	-63	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	DB04871	2312	47	None	-63	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	11666237	88683	0	None	-30	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337496	88683	0	None	-30	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365472	88683	0	None	-30	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	162652562	183075	0	None	-4	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4752604	183075	0	None	-4	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4802785	183075	0	None	-4	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	44572755	12353	1	None	-2	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL1186115	12353	1	None	-2	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL450599	12353	1	None	-2	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	22292784	64263	12	None	-17	3	Human	6.3	pEC50	=	6.3	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	CC1CNCCc2cc(Cl)ccc21	10.1016/j.bmcl.2004.12.080
	CHEMBL181672	64263	12	None	-17	3	Human	6.3	pEC50	=	6.3	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	CC1CNCCc2cc(Cl)ccc21	10.1016/j.bmcl.2004.12.080
	118733780	120128	0	None	-7	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	6	1	3	2.4	COCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416042	120128	0	None	-7	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	6	1	3	2.4	COCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546871	120128	0	None	-7	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	6	1	3	2.4	COCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	3572096	192296	1	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5186011	192296	1	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222066	192296	1	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	3572096	192296	1	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5186011	192296	1	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222066	192296	1	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	162670523	183168	0	None	-20	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4790652	183168	0	None	-20	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803766	183168	0	None	-20	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	146025688	183112	0	None	-20	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4761064	183112	0	None	-20	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4803134	183112	0	None	-20	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	146025688	183112	0	None	-20	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4761064	183112	0	None	-20	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4803134	183112	0	None	-20	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	11313985	90652	0	None	-18	3	Human	7.3	pEC50	=	7.3	Functional	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	232	1	1	3	0.7	COc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397878	90652	0	None	-18	3	Human	7.3	pEC50	=	7.3	Functional	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	232	1	1	3	0.7	COc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	11949710	198220	0	None	-50	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	355	4	1	4	3.5	Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL594717	198220	0	None	-50	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	355	4	1	4	3.5	Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21	10.1016/j.bmcl.2009.10.112
	118733772	120136	0	None	-2	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416038	120136	0	None	-2	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546893	120136	0	None	-2	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	11737939	83812	0	None	-2	2	Human	7.2	pEC50	=	7.2	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	2.1	O=C1c2c(ccc(Cl)c2Cl)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL220900	83812	0	None	-2	2	Human	7.2	pEC50	=	7.2	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	2.1	O=C1c2c(ccc(Cl)c2Cl)[C@@H]2CNCCN12	10.1021/jm0612968
	11291	3169	23	None	1	4	Human	7.2	pEC50	=	7.2	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1016/j.bmcl.2005.06.104
	4980	3169	23	None	1	4	Human	7.2	pEC50	=	7.2	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1016/j.bmcl.2005.06.104
	CHEMBL65547	3169	23	None	1	4	Human	7.2	pEC50	=	7.2	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1016/j.bmcl.2005.06.104
	162670523	183168	0	None	-20	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4790652	183168	0	None	-20	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803766	183168	0	None	-20	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	168283046	192290	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5185474	192290	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222039	192290	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	162676809	183210	0	None	-5	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4799299	183210	0	None	-5	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4804137	183210	0	None	-5	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	4240627	192332	1	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5198376	192332	1	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222297	192332	1	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	162676809	183210	0	None	-5	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4799299	183210	0	None	-5	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4804137	183210	0	None	-5	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	4240627	192332	1	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5198376	192332	1	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222297	192332	1	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	44431689	86821	0	None	-13	2	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	383	7	1	6	2.6	C[C@@H](N)Cc1c2c(c(COCC(=O)Oc3ccccc3)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	CHEMBL232995	86821	0	None	-13	2	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	383	7	1	6	2.6	C[C@@H](N)Cc1c2c(c(COCC(=O)Oc3ccccc3)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	44572800	12544	3	None	-5	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1cccc(Cl)c1	10.1021/jm801354e
	CHEMBL1187194	12544	3	None	-5	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1cccc(Cl)c1	10.1021/jm801354e
	CHEMBL493128	12544	3	None	-5	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1cccc(Cl)c1	10.1021/jm801354e
	168283046	192290	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5185474	192290	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222039	192290	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	44412403	77445	0	None	7	3	Human	7.2	pEC50	=	7.2	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	222	1	1	2	2.1	Clc1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	CHEMBL209254	77445	0	None	7	3	Human	7.2	pEC50	=	7.2	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	222	1	1	2	2.1	Clc1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	135399866	71711	2	None	-1	2	Rat	8.2	pEC50	=	8.2	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	209	2	2	4	1.2	C[C@H](N)Cn1ncc2ccc(O)c(F)c21	10.1021/jm050663x
	CHEMBL197653	71711	2	None	-1	2	Rat	8.2	pEC50	=	8.2	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	209	2	2	4	1.2	C[C@H](N)Cn1ncc2ccc(O)c(F)c21	10.1021/jm050663x
	44431705	144593	0	None	6	2	Rat	8.2	pEC50	=	8.2	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	313	2	2	4	1.7	C[C@@H](N)[C@H](O)c1c2c(c(Br)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	CHEMBL391196	144593	0	None	6	2	Rat	8.2	pEC50	=	8.2	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	313	2	2	4	1.7	C[C@@H](N)[C@H](O)c1c2c(c(Br)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	18735313	203226	1	None	6	3	Human	8.2	pEC50	=	8.2	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	210	2	1	2	2.1	C[C@H](N)CN1CCc2ccc(Cl)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL76307	203226	1	None	6	3	Human	8.2	pEC50	=	8.2	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	210	2	1	2	2.1	C[C@H](N)CN1CCc2ccc(Cl)cc21	10.1016/j.bmcl.2003.05.001
	162650400	183067	0	None	-22	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4748110	183067	0	None	-22	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4802669	183067	0	None	-22	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	54581791	61135	0	None	3	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770383	61135	0	None	3	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	162650400	183067	0	None	-22	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4748110	183067	0	None	-22	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4802669	183067	0	None	-22	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	53324165	56507	0	None	-9	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	231	2	2	5	0.8	CCNc1c2c(nc3ccnn13)CCNCC2	10.1016/j.bmcl.2010.11.089
	CHEMBL1643674	56507	0	None	-9	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	231	2	2	5	0.8	CCNc1c2c(nc3ccnn13)CCNCC2	10.1016/j.bmcl.2010.11.089
	122442263	137829	0	None	-30	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769454	137829	0	None	-30	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771393	137829	0	None	-30	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442263	137829	0	None	-30	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769454	137829	0	None	-30	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771393	137829	0	None	-30	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	118733800	120140	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416052	120140	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546904	120140	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	46230098	197649	0	None	-30	4	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	231	0	2	3	0.9	Cc1cccc2c1C(=O)NC1CCNCCN21	10.1016/j.bmcl.2009.12.014
	CHEMBL590580	197649	0	None	-30	4	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	231	0	2	3	0.9	Cc1cccc2c1C(=O)NC1CCNCCN21	10.1016/j.bmcl.2009.12.014
	134265705	163539	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	189	0	1	3	0.8	c1cnc2c(c1)CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4209572	163539	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	189	0	1	3	0.8	c1cnc2c(c1)CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	54584721	61129	0	None	-1	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770377	61129	0	None	-1	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	118733812	120130	0	None	-4	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	CHEMBL3416058	120130	0	None	-4	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	CHEMBL3546873	120130	0	None	-4	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	24849050	77897	2	None	-2	3	Human	7.2	pEC50	=	7.2	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CC[C@H]3CNC[C@H]32)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL210802	77897	2	None	-2	3	Human	7.2	pEC50	=	7.2	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CC[C@H]3CNC[C@H]32)n1	10.1016/j.bmcl.2006.03.007
	10036629	64306	0	None	-9	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)C(C)CNCC2	10.1021/jm0709034
	CHEMBL181787	64306	0	None	-9	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)C(C)CNCC2	10.1021/jm0709034
	24773728	94419	0	None	-31	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	1	1	1	3.0	CC[C@@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL253810	94419	0	None	-31	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	1	1	1	3.0	CC[C@@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	118733806	120143	0	None	-19	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	CHEMBL3416055	120143	0	None	-19	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	CHEMBL3546907	120143	0	None	-19	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	10064386	62987	4	None	-32	3	Human	7.2	pEC50	=	7.2	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	317	1	1	2	2.5	COc1cc2c(cc1I)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL179378	62987	4	None	-32	3	Human	7.2	pEC50	=	7.2	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	317	1	1	2	2.5	COc1cc2c(cc1I)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	44572802	12338	2	None	-13	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL1186019	12338	2	None	-13	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL445747	12338	2	None	-13	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	11983273	77642	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	256	1	1	2	2.5	FC(F)(F)c1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	CHEMBL209714	77642	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	256	1	1	2	2.5	FC(F)(F)c1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	118733796	120129	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.3	C=C(F)COc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416050	120129	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.3	C=C(F)COc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546872	120129	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.3	C=C(F)COc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	44572747	12596	2	None	-2	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccccc1F	10.1021/jm801354e
	CHEMBL1187580	12596	2	None	-2	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccccc1F	10.1021/jm801354e
	CHEMBL510308	12596	2	None	-2	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccccc1F	10.1021/jm801354e
	44573217	186756	0	None	10	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	302	3	2	3	2.2	O=S(=O)(Nc1ccccc1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL493152	186756	0	None	10	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	302	3	2	3	2.2	O=S(=O)(Nc1ccccc1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	44572174	12440	0	None	-2	3	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	2	1	1	2.7	Cc1cccc(Cl)c1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL1186687	12440	0	None	-2	3	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	2	1	1	2.7	Cc1cccc(Cl)c1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL474634	12440	0	None	-2	3	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	2	1	1	2.7	Cc1cccc(Cl)c1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	44316017	203741	0	None	4	3	Human	8.1	pEC50	=	8.1	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	228	2	1	2	2.2	C[C@H](N)CN1CCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL80366	203741	0	None	4	3	Human	8.1	pEC50	=	8.1	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	228	2	1	2	2.2	C[C@H](N)CN1CCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2003.05.001
	11644842	88668	0	None	-12	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	244	1	2	2	1.9	Cc1cc(C(C)C)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337105	88668	0	None	-12	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	244	1	2	2	1.9	Cc1cc(C(C)C)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365394	88668	0	None	-12	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	244	1	2	2	1.9	Cc1cc(C(C)C)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	53321865	56554	0	None	-19	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)nc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643855	56554	0	None	-19	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)nc1	10.1016/j.bmcl.2010.11.089
	122442273	137828	0	None	-5	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771152	137828	0	None	-5	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771392	137828	0	None	-5	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44316027	203811	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	236	4	1	3	2.5	CCSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	CHEMBL80862	203811	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	236	4	1	3	2.5	CCSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	162644827	183041	0	None	-109	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4739937	183041	0	None	-109	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802378	183041	0	None	-109	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	162660358	183122	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4762722	183122	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803207	183122	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	122442273	137828	0	None	-5	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771152	137828	0	None	-5	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771392	137828	0	None	-5	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	162644827	183041	0	None	-109	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4739937	183041	0	None	-109	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802378	183041	0	None	-109	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	53317925	56558	0	None	-8	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	390	3	2	7	1.2	O=C1Cc2cc(OC3CN(c4c5c(nc6ccnn46)CCNCC5)C3)ccc2N1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643859	56558	0	None	-8	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	390	3	2	7	1.2	O=C1Cc2cc(OC3CN(c4c5c(nc6ccnn46)CCNCC5)C3)ccc2N1	10.1016/j.bmcl.2010.11.089
	162660358	183122	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4762722	183122	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803207	183122	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	118733816	120147	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416060	120147	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546911	120147	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	10624	69957	17	None	6	3	Human	7.1	pEC50	=	7.1	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	138543650	69957	17	None	6	3	Human	7.1	pEC50	=	7.1	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL194378	69957	17	None	6	3	Human	7.1	pEC50	=	7.1	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	46228422	198353	0	None	-33	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1O[C@@H]1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL595553	198353	0	None	-33	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1O[C@@H]1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	44572806	12545	1	None	-4	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL1187195	12545	1	None	-4	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL493129	12545	1	None	-4	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	44573218	192455	0	None	2	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	320	3	2	3	2.3	O=S(=O)(Nc1ccccc1F)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL522349	192455	0	None	2	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	320	3	2	3	2.3	O=S(=O)(Nc1ccccc1F)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	1534	102566	51	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	9287	102566	51	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	CHEMBL30713	102566	51	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	1534	102566	51	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	9287	102566	51	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	CHEMBL30713	102566	51	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	162659049	183111	0	None	-8	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4761526	183111	0	None	-8	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803123	183111	0	None	-8	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	134265620	163854	0	None	-6456	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	279	2	1	3	2.4	c1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1	10.1021/acsmedchemlett.8b00328
	CHEMBL4213379	163854	0	None	-6456	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	279	2	1	3	2.4	c1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1	10.1021/acsmedchemlett.8b00328
	162659049	183111	0	None	-8	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4761526	183111	0	None	-8	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803123	183111	0	None	-8	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	44572804	12514	1	None	-2	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1cccc(C(F)(F)F)c1	10.1021/jm801354e
	CHEMBL1187088	12514	1	None	-2	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1cccc(C(F)(F)F)c1	10.1021/jm801354e
	CHEMBL490064	12514	1	None	-2	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1cccc(C(F)(F)F)c1	10.1021/jm801354e
	162669436	183163	0	None	-19	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4789310	183163	0	None	-19	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803705	183163	0	None	-19	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	134265590	164206	0	None	-2	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	189	0	1	3	0.8	c1cc2c(cn1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	CHEMBL4217846	164206	0	None	-2	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	189	0	1	3	0.8	c1cc2c(cn1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	9991444	62303	0	None	-15	3	Human	7.1	pEC50	=	7.1	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2cc(Cl)c(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178366	62303	0	None	-15	3	Human	7.1	pEC50	=	7.1	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2cc(Cl)c(Cl)cc21	10.1016/j.bmcl.2004.12.080
	24773900	122916	8	None	-6	3	Human	6.1	pEC50	=	6.1	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL361742	122916	8	None	-6	3	Human	6.1	pEC50	=	6.1	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	162669436	183163	0	None	-19	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4789310	183163	0	None	-19	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803705	183163	0	None	-19	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	11658860	2312	47	None	-63	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	2941	2312	47	None	-63	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	4374	2312	47	None	-63	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	CHEMBL360328	2312	47	None	-63	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	DB04871	2312	47	None	-63	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	10105208	62170	0	None	-83	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	CC1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	CHEMBL178124	62170	0	None	-83	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	CC1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	11160564	62974	4	None	-40	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2c(Cl)cc(Cl)cc21	10.1021/jm0709034
	CHEMBL179337	62974	4	None	-40	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2c(Cl)cc(Cl)cc21	10.1021/jm0709034
	23395431	94472	0	None	-79	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	C[C@@H]1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	CHEMBL254215	94472	0	None	-79	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	C[C@@H]1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	16115517	84414	0	None	-5	3	Human	8.1	pEC50	=	8.1	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.4	CCc1ccc2c(c1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL223468	84414	0	None	-5	3	Human	8.1	pEC50	=	8.1	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.4	CCc1ccc2c(c1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	44572178	12454	0	None	-1	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1cccc([C@H]2C[C@@H]2CN)c1C	10.1021/jm801354e
	CHEMBL1186736	12454	0	None	-1	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1cccc([C@H]2C[C@@H]2CN)c1C	10.1021/jm801354e
	CHEMBL475642	12454	0	None	-1	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1cccc([C@H]2C[C@@H]2CN)c1C	10.1021/jm801354e
	135520431	72264	9	None	-1	2	Rat	8.1	pEC50	=	8.1	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	177	2	2	4	0.7	NCCn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL199385	72264	9	None	-1	2	Rat	8.1	pEC50	=	8.1	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	177	2	2	4	0.7	NCCn1ncc2ccc(O)cc21	10.1021/jm050663x
	135414348	72464	2	None	-1	2	Rat	8.1	pEC50	=	8.1	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	205	2	2	4	1.4	Cc1c(O)ccc2cnn(C[C@H](C)N)c12	10.1021/jm050663x
	CHEMBL200104	72464	2	None	-1	2	Rat	8.1	pEC50	=	8.1	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	205	2	2	4	1.4	Cc1c(O)ccc2cnn(C[C@H](C)N)c12	10.1021/jm050663x
	44573154	186615	0	None	-17	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	350	4	2	3	2.5	O=S(=O)(NCc1ccccc1Cl)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492349	186615	0	None	-17	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	350	4	2	3	2.5	O=S(=O)(NCc1ccccc1Cl)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	45484662	196814	0	None	-2	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1cccc(Cl)c1)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL577691	196814	0	None	-2	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1cccc(Cl)c1)CCNCC2	10.1016/j.bmcl.2009.07.063
	11231392	84470	0	None	-7	3	Human	6.1	pEC50	=	6.1	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.6	CC(C)Oc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	CHEMBL223628	84470	0	None	-7	3	Human	6.1	pEC50	=	6.1	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.6	CC(C)Oc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	71682217	90687	0	None	-10	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	246	1	1	3	1.0	COc1c(C)ccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397913	90687	0	None	-10	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	246	1	1	3	1.0	COc1c(C)ccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	44572170	12359	1	None	-4	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1Cl	10.1021/jm801354e
	CHEMBL1186164	12359	1	None	-4	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1Cl	10.1021/jm801354e
	CHEMBL452458	12359	1	None	-4	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1Cl	10.1021/jm801354e
	118733810	120145	0	None	-9	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	CHEMBL3416057	120145	0	None	-9	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	CHEMBL3546909	120145	0	None	-9	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	162657367	183100	0	None	-32	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4756903	183100	0	None	-32	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803034	183100	0	None	-32	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	45484700	195627	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	295	3	1	4	1.9	O=c1cc2c(nn1Cc1ccc(C3CC3)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL568692	195627	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	295	3	1	4	1.9	O=c1cc2c(nn1Cc1ccc(C3CC3)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	11160564	62974	4	None	-40	3	Human	6.1	pEC50	=	6.1	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2c(Cl)cc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL179337	62974	4	None	-40	3	Human	6.1	pEC50	=	6.1	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2c(Cl)cc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	53320653	56506	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	245	2	1	5	0.9	CCN(C)c1c2c(nc3ccnn13)CCNCC2	10.1016/j.bmcl.2010.11.089
	CHEMBL1643673	56506	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	245	2	1	5	0.9	CCN(C)c1c2c(nc3ccnn13)CCNCC2	10.1016/j.bmcl.2010.11.089
	135399666	168198	4	None	1	6	Rat	7.1	pEC50	=	7.1	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	191	2	2	4	1.1	C[C@@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL437314	168198	4	None	1	6	Rat	7.1	pEC50	=	7.1	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	191	2	2	4	1.1	C[C@@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	12370465	12565	16	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NCC1CC1c1ccccc1	10.1021/jm801354e
	CHEMBL1187354	12565	16	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NCC1CC1c1ccccc1	10.1021/jm801354e
	CHEMBL500093	12565	16	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NCC1CC1c1ccccc1	10.1021/jm801354e
	162657367	183100	0	None	-32	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4756903	183100	0	None	-32	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803034	183100	0	None	-32	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	118733762	120132	0	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416033	120132	0	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546889	120132	0	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	11437171	83077	0	None	-2	3	Human	7.1	pEC50	=	7.1	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	234	1	1	3	1.5	CSc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	CHEMBL220207	83077	0	None	-2	3	Human	7.1	pEC50	=	7.1	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	234	1	1	3	1.5	CSc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	168286640	192326	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5194223	192326	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222252	192326	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	168294430	192405	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5205429	192405	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222746	192405	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	168294430	192405	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5205429	192405	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222746	192405	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	24826868	90651	1	None	1	3	Human	8.1	pEC50	=	8.1	Functional	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	236	0	1	2	1.3	O=C1c2cc(Cl)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397877	90651	1	None	1	3	Human	8.1	pEC50	=	8.1	Functional	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	236	0	1	2	1.3	O=C1c2cc(Cl)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	11695000	88642	0	None	-7	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337490	88642	0	None	-7	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365083	88642	0	None	-7	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	122461343	137834	0	None	-9	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769704	137834	0	None	-9	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771398	137834	0	None	-9	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	7153	97570	74	None	1	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	10.1016/j.bmc.2007.10.100
	CHEMBL272942	97570	74	None	1	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	10.1016/j.bmc.2007.10.100
	154699445	176852	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Antagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assayAntagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assay	ChEMBL	319	4	0	4	4.2	CCP(=O)(OC)c1ccc2oc(-c3ccc(F)cc3)nc2c1	10.1021/acs.jmedchem.0c00807
	CHEMBL4638592	176852	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Antagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assayAntagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assay	ChEMBL	319	4	0	4	4.2	CCP(=O)(OC)c1ccc2oc(-c3ccc(F)cc3)nc2c1	10.1021/acs.jmedchem.0c00807
	122461343	137834	0	None	-9	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769704	137834	0	None	-9	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771398	137834	0	None	-9	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11514226	88681	0	None	-85	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337494	88681	0	None	-85	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365470	88681	0	None	-85	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	45484661	197203	0	None	-2	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1ccccc1Cl)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL584210	197203	0	None	-2	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1ccccc1Cl)CCNCC2	10.1016/j.bmcl.2009.07.063
	53325935	56503	0	None	-17	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	243	1	1	5	0.6	c1cc2nc3c(c(N4CCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	CHEMBL1643670	56503	0	None	-17	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	243	1	1	5	0.6	c1cc2nc3c(c(N4CCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	53324630	56509	0	None	-18	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1ccccc1OC1CN(c2c3c(nc4ccnn24)CCNCC3)C1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643676	56509	0	None	-18	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1ccccc1OC1CN(c2c3c(nc4ccnn24)CCNCC3)C1	10.1016/j.bmcl.2010.11.089
	11658860	2312	47	None	-63	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	2941	2312	47	None	-63	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	4374	2312	47	None	-63	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	CHEMBL360328	2312	47	None	-63	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	DB04871	2312	47	None	-63	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	11658860	2312	47	None	-63	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysisAgonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysis	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	2941	2312	47	None	-63	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysisAgonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysis	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	4374	2312	47	None	-63	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysisAgonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysis	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	CHEMBL360328	2312	47	None	-63	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysisAgonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysis	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	DB04871	2312	47	None	-63	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysisAgonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysis	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	122442275	137833	0	None	-11	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3770862	137833	0	None	-11	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3771397	137833	0	None	-11	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	122442275	137833	0	None	-11	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3770862	137833	0	None	-11	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3771397	137833	0	None	-11	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	168288743	192345	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5192627	192345	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222395	192345	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	4543677	192188	1	None	-2	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5179287	192188	1	None	-2	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221372	192188	1	None	-2	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	4543677	192188	1	None	-2	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5179287	192188	1	None	-2	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221372	192188	1	None	-2	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	168288743	192345	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5192627	192345	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222395	192345	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	118733774	120138	0	None	-10	3	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416039	120138	0	None	-10	3	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546902	120138	0	None	-10	3	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	46228430	198056	0	None	-8	3	Human	6.0	pEC50	=	6	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	343	3	1	4	3.6	Clc1ccccc1O[C@@H]1CCCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL593545	198056	0	None	-8	3	Human	6.0	pEC50	=	6	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	343	3	1	4	3.6	Clc1ccccc1O[C@@H]1CCCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	44138039	178709	8	None	-	1	Human	9.7	pIC50	=	9.7	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	363	4	1	2	4.3	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473185	178709	8	None	-	1	Human	9.7	pIC50	=	9.7	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	363	4	1	2	4.3	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565847	179987	0	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	367	4	1	3	3.6	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL475407	179987	0	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	367	4	1	3	3.6	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565831	179855	0	None	-	1	Human	9.4	pIC50	=	9.4	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	345	4	1	2	4.2	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL475245	179855	0	None	-	1	Human	9.4	pIC50	=	9.4	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	345	4	1	2	4.2	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565608	178689	0	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	385	4	1	3	3.8	O=S(=O)(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472990	178689	0	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	385	4	1	3	3.8	O=S(=O)(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	188	3339	73	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1016/j.bmcl.2009.02.126
	196968	3339	73	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1016/j.bmcl.2009.02.126
	CHEMBL473186	3339	73	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1016/j.bmcl.2009.02.126
	44565850	179153	0	None	-	1	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	349	3	1	2	4.2	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL474408	179153	0	None	-	1	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	349	3	1	2	4.2	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	4366334	79999	8	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	379	3	0	4	4.6	CCCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL214554	79999	8	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	379	3	0	4	4.6	CCCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	44565638	189037	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	417	4	1	3	4.8	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL514934	189037	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	417	4	1	3	4.8	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	3743171	79724	13	None	-	1	Human	7.0	pIC50	=	7	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	445	1	0	4	5.1	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(Cl)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL213329	79724	13	None	-	1	Human	7.0	pIC50	=	7	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	445	1	0	4	5.1	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(Cl)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	145976085	163113	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	CHEMBL4204576	163113	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	145972374	164122	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	388	6	3	7	1.3	COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H]1N=C(c2ccccc2O)S[C@@H]1C	10.1021/acs.jnatprod.7b00317
	CHEMBL4216860	164122	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	388	6	3	7	1.3	COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H]1N=C(c2ccccc2O)S[C@@H]1C	10.1021/acs.jnatprod.7b00317
	44565828	178619	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	395	3	0	3	5.3	Cn1c(C2CCN(C(=O)c3ccc(-c4ccccc4)cc3)CC2)nc2ccccc21	10.1016/j.bmcl.2009.02.126
	CHEMBL472416	178619	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	395	3	0	3	5.3	Cn1c(C2CCN(C(=O)c3ccc(-c4ccccc4)cc3)CC2)nc2ccccc21	10.1016/j.bmcl.2009.02.126
	127035063	135963	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	477	13	0	6	5.2	COc1ccccc1CCCN(CCc1ccc(OC)c(OC)c1)CCc1ccc2c(c1)OCO2	10.1039/C4MD00418C
	CHEMBL3736149	135963	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	477	13	0	6	5.2	COc1ccccc1CCCN(CCc1ccc(OC)c(OC)c1)CCc1ccc2c(c1)OCO2	10.1039/C4MD00418C
	127037093	135985	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	433	11	0	5	4.8	COc1ccc(CCN(CCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3736252	135985	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	433	11	0	5	4.8	COc1ccc(CCN(CCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	118464427	137806	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	328	3	4	6	1.8	CCNC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3771331	137806	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	328	3	4	6	1.8	CCNC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	752565	137761	7	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	273	2	3	6	1.7	COc1cccc(NC2=NC(N)=NC3(CCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770770	137761	7	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	273	2	3	6	1.7	COc1cccc(NC2=NC(N)=NC3(CCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	44565849	178715	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	431	5	1	3	4.9	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473235	178715	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	431	5	1	3	4.9	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565805	189042	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	387	3	1	2	5.6	O=C(c1ccc(C2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL514967	189042	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	387	3	1	2	5.6	O=C(c1ccc(C2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44416247	140926	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	393	3	0	4	4.9	CCCN1CCC2(CC1)Oc1ccc(C)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL384255	140926	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	393	3	0	4	4.9	CCCN1CCC2(CC1)Oc1ccc(C)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	44156863	7995	0	None	-21	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	345	3	0	6	2.8	CSc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CCC3	10.1016/j.bmcl.2010.02.046
	CHEMBL1091206	7995	0	None	-21	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	345	3	0	6	2.8	CSc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CCC3	10.1016/j.bmcl.2010.02.046
	44565827	178618	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2ccccc2)cn1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472415	178618	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2ccccc2)cn1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565636	178688	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	383	3	1	4	4.0	O=C(c1ccc(-c2ncccn2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472986	178688	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	383	3	1	4	4.0	O=C(c1ccc(-c2ncccn2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	16812804	170554	9	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	381	3	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL445809	170554	9	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	381	3	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565606	178661	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	411	4	1	3	5.3	COc1cc(-c2ccccc2)ccc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472789	178661	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	411	4	1	3	5.3	COc1cc(-c2ccccc2)ccc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565806	179528	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	388	3	1	3	4.6	O=C(c1ccc(N2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL474839	179528	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	388	3	1	3	4.6	O=C(c1ccc(N2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	168295984	191622	0	None	-8	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR methodAntagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR method	ChEMBL	431	6	0	5	5.0	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccccc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL5204813	191622	0	None	-8	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR methodAntagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR method	ChEMBL	431	6	0	5	5.0	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccccc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	127034715	135871	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	537	15	0	8	5.2	COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3735261	135871	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	537	15	0	8	5.2	COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	127035064	135948	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	477	13	0	6	5.2	COc1cccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
	CHEMBL3735911	135948	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	477	13	0	6	5.2	COc1cccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
	127034730	135916	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	523	14	0	8	5.1	COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)Cc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3735643	135916	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	523	14	0	8	5.1	COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)Cc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	46830134	8133	0	None	-37	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	373	3	0	6	3.5	CSc1nn2c(C)c3c(nc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1016/j.bmcl.2010.02.046
	CHEMBL1092241	8133	0	None	-37	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	373	3	0	6	3.5	CSc1nn2c(C)c3c(nc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1016/j.bmcl.2010.02.046
	3781561	138069	6	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	441	2	0	5	4.4	COc1cccc2c1OC1(CCN(C)CC1)N1N=C(c3ccc(Br)cc3)CC21	10.1016/j.bmcl.2006.06.068
	CHEMBL377562	138069	6	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	441	2	0	5	4.4	COc1cccc2c1OC1(CCN(C)CC1)N1N=C(c3ccc(Br)cc3)CC21	10.1016/j.bmcl.2006.06.068
	10449757	3439	26	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10.1016/j.bmcl.2009.02.126
	190	3439	26	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10.1016/j.bmcl.2009.02.126
	CHEMBL2110371	3439	26	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10.1016/j.bmcl.2009.02.126
	71528206	86543	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection methodAntagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection method	ChEMBL	314	3	0	4	2.8	COC(OC)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	CHEMBL2323581	86543	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection methodAntagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection method	ChEMBL	314	3	0	4	2.8	COC(OC)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	3830738	141114	7	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	395	2	0	4	5.1	CC(C)N1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(Cl)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL385346	141114	7	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	395	2	0	4	5.1	CC(C)N1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(Cl)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	44565831	179855	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	345	4	1	2	4.2	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL475245	179855	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	345	4	1	2	4.2	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	145988313	166682	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs by fluorescence assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs by fluorescence assay	ChEMBL	451	6	2	2	5.0	O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1039/C8MD00204E
	CHEMBL4292326	166682	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs by fluorescence assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs by fluorescence assay	ChEMBL	451	6	2	2	5.0	O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1039/C8MD00204E
	4203621	138459	14	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	397	2	0	5	4.3	COc1cccc2c1OC1(CCN(C)CC1)N1N=C(c3ccc(Cl)cc3)CC21	10.1016/j.bmcl.2006.06.068
	CHEMBL378541	138459	14	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	397	2	0	5	4.3	COc1cccc2c1OC1(CCN(C)CC1)N1N=C(c3ccc(Cl)cc3)CC21	10.1016/j.bmcl.2006.06.068
	3898525	139049	8	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	362	3	0	5	3.8	CCCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL379734	139049	8	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	362	3	0	5	3.8	CCCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	44565635	178687	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2ccccn2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472985	178687	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2ccccn2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565641	178738	1	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	353	3	1	2	4.5	O=C(c1ccc(-c2ccccc2)cc1)N1CC(c2nc3ccccc3[nH]2)C1	10.1016/j.bmcl.2009.02.126
	CHEMBL473391	178738	1	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	353	3	1	2	4.5	O=C(c1ccc(-c2ccccc2)cc1)N1CC(c2nc3ccccc3[nH]2)C1	10.1016/j.bmcl.2009.02.126
	44565829	178639	2	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	0	3	5.5	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3o2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472589	178639	2	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	0	3	5.5	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3o2)CC1	10.1016/j.bmcl.2009.02.126
	53327611	69411	0	None	-154	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at 5HT2B receptorAntagonist activity at 5HT2B receptor	ChEMBL	401	2	1	5	3.6	O=S(=O)(c1cccc(F)c1)c1ccc2c3c(oc2c1)C1(CCCOC1)NCC3	10.1016/j.bmcl.2011.11.050
	CHEMBL1935601	69411	0	None	-154	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at 5HT2B receptorAntagonist activity at 5HT2B receptor	ChEMBL	401	2	1	5	3.6	O=S(=O)(c1cccc(F)c1)c1ccc2c3c(oc2c1)C1(CCCOC1)NCC3	10.1016/j.bmcl.2011.11.050
	44416290	140852	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	424	4	0	5	4.7	c1ccc(CCN2CCC3(CC2)Oc2ccccc2C2CC(c4ccncc4)=NN23)cc1	10.1016/j.bmcl.2006.06.068
	CHEMBL383860	140852	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	424	4	0	5	4.7	c1ccc(CCN2CCC3(CC2)Oc2ccccc2C2CC(c4ccncc4)=NN23)cc1	10.1016/j.bmcl.2006.06.068
	44565824	178713	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	465	4	1	3	6.1	O=C(c1ccc(-c2ccc(OC(F)(F)F)cc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473214	178713	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	465	4	1	3	6.1	O=C(c1ccc(-c2ccc(OC(F)(F)F)cc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44155109	8090	3	None	-21	2	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	373	3	0	6	3.5	CSc1nn2c3c(c(C)nc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1016/j.bmcl.2010.02.046
	CHEMBL1091919	8090	3	None	-21	2	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	373	3	0	6	3.5	CSc1nn2c3c(c(C)nc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1016/j.bmcl.2010.02.046
	732268	137768	28	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	257	1	3	5	2.0	NC1=NC2(CCCCC2)NC(Nc2ccccc2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL3770837	137768	28	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	257	1	3	5	2.0	NC1=NC2(CCCCC2)NC(Nc2ccccc2)=N1	10.1021/acsmedchemlett.8b00300
	44565635	178687	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2ccccn2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472985	178687	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2ccccn2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	3716424	80638	6	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	477	3	0	5	5.0	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(OC(F)F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL215380	80638	6	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	477	3	0	5	5.0	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(OC(F)F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	3826158	79517	11	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	469	4	0	5	5.2	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(OC)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL212506	79517	11	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	469	4	0	5	5.2	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(OC)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	118464428	137733	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	343	4	3	7	2.6	CCCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770512	137733	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	343	4	3	7	2.6	CCCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	145988313	166682	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs in presence of human serum albumin by fluorescence assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs in presence of human serum albumin by fluorescence assay	ChEMBL	451	6	2	2	5.0	O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1039/C8MD00204E
	CHEMBL4292326	166682	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs in presence of human serum albumin by fluorescence assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs in presence of human serum albumin by fluorescence assay	ChEMBL	451	6	2	2	5.0	O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1039/C8MD00204E
	136020618	163362	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	CHEMBL4207302	163362	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	3736302	138389	7	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	439	2	0	4	5.2	CC(C)N1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL378357	138389	7	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	439	2	0	4	5.2	CC(C)N1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3)=NN12	10.1016/j.bmcl.2006.06.068
	188	3339	73	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1016/j.bmcl.2009.02.126
	196968	3339	73	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1016/j.bmcl.2009.02.126
	CHEMBL473186	3339	73	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1016/j.bmcl.2009.02.126
	145979048	166105	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	407	3	3	7	3.0	CCOC(=O)c1cc(Br)cc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acsmedchemlett.8b00300
	CHEMBL4281546	166105	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	407	3	3	7	3.0	CCOC(=O)c1cc(Br)cc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acsmedchemlett.8b00300
	44565846	179986	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	395	4	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL475406	179986	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	395	4	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	16812804	170554	9	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	381	3	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL445809	170554	9	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	381	3	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565830	179142	2	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	331	3	1	2	4.1	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL474404	179142	2	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	331	3	1	2	4.1	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565605	189101	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	383	3	1	4	4.0	O=C(c1cnc(-c2ccccc2)nc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL515422	189101	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	383	3	1	4	4.0	O=C(c1cnc(-c2ccccc2)nc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44416309	140909	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	376	3	0	5	4.1	CC(C)CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL384160	140909	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	376	3	0	5	4.1	CC(C)CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	145993660	166815	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	413	1	3	5	3.6	NC1=NC2(CCCCC2)NC(Nc2cc(Br)cc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL4294723	166815	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	413	1	3	5	3.6	NC1=NC2(CCCCC2)NC(Nc2cc(Br)cc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
	44565637	178710	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	398	3	2	3	3.9	O=C(c1ccc(-c2ccccc2)[nH]c1=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473187	178710	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	398	3	2	3	3.9	O=C(c1ccc(-c2ccccc2)[nH]c1=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	71528204	86541	0	None	-15	3	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection methodAntagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection method	ChEMBL	439	6	1	5	2.6	CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	CHEMBL2323579	86541	0	None	-15	3	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection methodAntagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection method	ChEMBL	439	6	1	5	2.6	CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	118464429	166564	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	383	1	3	5	2.6	NC1=NC2(CCCCC2)NC(Nc2cccc(I)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL4290245	166564	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	383	1	3	5	2.6	NC1=NC2(CCCCC2)NC(Nc2cccc(I)c2)=N1	10.1021/acsmedchemlett.8b00300
	26694436	162362	2	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at 5-HT2B (unknown origin)Antagonist activity at 5-HT2B (unknown origin)	ChEMBL	354	5	2	3	2.9	CC(C)NS(=O)(=O)c1cccc(C(=O)Nc2ccc(F)c(F)c2)c1	10.1021/acs.jmedchem.8b00654
	CHEMBL4173963	162362	2	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at 5-HT2B (unknown origin)Antagonist activity at 5-HT2B (unknown origin)	ChEMBL	354	5	2	3	2.9	CC(C)NS(=O)(=O)c1cccc(C(=O)Nc2ccc(F)c(F)c2)c1	10.1021/acs.jmedchem.8b00654
	44565807	179530	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	390	3	1	4	3.4	O=C(c1ccc(N2CCOCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL474840	179530	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	390	3	1	4	3.4	O=C(c1ccc(N2CCOCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44416259	137675	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	397	3	0	4	4.7	CCCN1CCC2(CC1)Oc1ccc(F)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL376978	137675	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	397	3	0	4	4.7	CCCN1CCC2(CC1)Oc1ccc(F)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	3649661	137691	6	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	329	3	3	7	2.2	CCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770106	137691	6	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	329	3	3	7	2.2	CCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	11502243	188916	39	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	401	4	1	6	4.4	N#Cc1cc(CN2CCC(Nc3ncnc4sc(Cl)cc34)CC2)ccc1F	10.1016/j.bmcl.2009.02.126
	CHEMBL513994	188916	39	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	401	4	1	6	4.4	N#Cc1cc(CN2CCC(Nc3ncnc4sc(Cl)cc34)CC2)ccc1F	10.1016/j.bmcl.2009.02.126
	11949710	198220	0	None	-50	3	Human	7.6	pIC50	=	7.6	Functional	Agonist activity against human 5HT2B receptor by FLIPR assay relative to 5HTAgonist activity against human 5HT2B receptor by FLIPR assay relative to 5HT	ChEMBL	355	4	1	4	3.5	Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL594717	198220	0	None	-50	3	Human	7.6	pIC50	=	7.6	Functional	Agonist activity against human 5HT2B receptor by FLIPR assay relative to 5HTAgonist activity against human 5HT2B receptor by FLIPR assay relative to 5HT	ChEMBL	355	4	1	4	3.5	Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21	10.1016/j.bmcl.2009.10.112
	5093797	80661	6	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	367	1	0	4	4.3	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(Cl)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL215461	80661	6	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	367	1	0	4	4.3	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(Cl)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	895660	32177	8	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	287	2	3	6	2.0	COc1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL1411080	32177	8	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	287	2	3	6	2.0	COc1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	118464425	137781	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	357	3	2	7	2.8	CCOC(=O)c1cccc(NC2=NC(N(C)C)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770981	137781	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	357	3	2	7	2.8	CCOC(=O)c1cccc(NC2=NC(N(C)C)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	5113614	79651	7	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	457	3	0	4	5.3	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL213005	79651	7	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	457	3	0	4	5.3	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	44565808	180329	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	411	4	1	3	5.3	COc1ccc(-c2ccc(C(=O)N3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	CHEMBL475778	180329	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	411	4	1	3	5.3	COc1ccc(-c2ccc(C(=O)N3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	11502243	188916	39	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	401	4	1	6	4.4	N#Cc1cc(CN2CCC(Nc3ncnc4sc(Cl)cc34)CC2)ccc1F	10.1016/j.bmcl.2009.02.126
	CHEMBL513994	188916	39	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	401	4	1	6	4.4	N#Cc1cc(CN2CCC(Nc3ncnc4sc(Cl)cc34)CC2)ccc1F	10.1016/j.bmcl.2009.02.126
	11957541	1430	38	None	1	4	Human	8.5	pIC50	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	1229	1430	38	None	1	4	Human	8.5	pIC50	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	147	1430	38	None	1	4	Human	8.5	pIC50	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	170617	1430	38	None	1	4	Human	8.5	pIC50	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	CHEMBL6616	1430	38	None	1	4	Human	8.5	pIC50	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	3723094	79554	10	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	429	1	0	4	4.6	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL212656	79554	10	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	429	1	0	4	4.6	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	44565608	178689	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	385	4	1	3	3.8	O=S(=O)(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472990	178689	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	385	4	1	3	3.8	O=S(=O)(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565846	179986	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	395	4	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL475406	179986	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	395	4	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	168284710	190997	0	None	-18	3	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR methodAntagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR method	ChEMBL	509	6	0	5	5.8	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccc(Br)cc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL5195241	190997	0	None	-18	3	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR methodAntagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR method	ChEMBL	509	6	0	5	5.8	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccc(Br)cc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	136020617	57025	0	None	-	1	Human	4.5	pIC50	=	4.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@@H]1CO	10.1021/acs.jnatprod.7b00317
	CHEMBL1651095	57025	0	None	-	1	Human	4.5	pIC50	=	4.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@@H]1CO	10.1021/acs.jnatprod.7b00317
	44565805	189042	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	387	3	1	2	5.6	O=C(c1ccc(C2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL514967	189042	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	387	3	1	2	5.6	O=C(c1ccc(C2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44416260	79581	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	413	3	0	4	5.2	CCCN1CCC2(CC1)Oc1ccc(Cl)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL212755	79581	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	413	3	0	4	5.2	CCCN1CCC2(CC1)Oc1ccc(Cl)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	44565847	179987	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	367	4	1	3	3.6	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL475407	179987	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	367	4	1	3	3.6	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565808	180329	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	411	4	1	3	5.3	COc1ccc(-c2ccc(C(=O)N3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	CHEMBL475778	180329	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	411	4	1	3	5.3	COc1ccc(-c2ccc(C(=O)N3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	11248240	2626	2	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	462	5	4	8	1.8	CNC(=O)[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)Cl	10.1021/acs.jmedchem.6b01183
	5601	2626	2	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	462	5	4	8	1.8	CNC(=O)[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)Cl	10.1021/acs.jmedchem.6b01183
	CHEMBL175543	2626	2	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	462	5	4	8	1.8	CNC(=O)[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)Cl	10.1021/acs.jmedchem.6b01183
	752521	197060	7	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	295	1	3	5	1.9	CC1(C)N=C(N)N=C(Nc2cccc(Br)c2)N1	10.1021/acs.jmedchem.5b01631
	CHEMBL582877	197060	7	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	295	1	3	5	1.9	CC1(C)N=C(N)N=C(Nc2cccc(Br)c2)N1	10.1021/acs.jmedchem.5b01631
	118464420	137717	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770342	137717	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acs.jmedchem.5b01631
	44565634	178662	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2cccnc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472791	178662	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2cccnc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565850	179153	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	349	3	1	2	4.2	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL474408	179153	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	349	3	1	2	4.2	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	118464420	137717	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL3770342	137717	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
	118464426	137718	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	327	4	3	6	3.0	CCCC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770351	137718	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	327	4	3	6	3.0	CCCC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	3751272	80184	13	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	443	3	0	4	5.9	Clc1ccc(C2=NN3C(C2)c2ccccc2OC32CCN(Cc3ccccc3)CC2)cc1	10.1016/j.bmcl.2006.06.068
	CHEMBL215024	80184	13	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	443	3	0	4	5.9	Clc1ccc(C2=NN3C(C2)c2ccccc2OC32CCN(Cc3ccccc3)CC2)cc1	10.1016/j.bmcl.2006.06.068
	71528205	86542	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection methodAntagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection method	ChEMBL	368	5	1	4	2.2	CN(C)CCCNC(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	CHEMBL2323580	86542	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection methodAntagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection method	ChEMBL	368	5	1	4	2.2	CN(C)CCCNC(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	145963830	163571	0	None	3	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	335	4	2	4	4.0	Oc1ccccc1C1=NC(Cc2c[nH]cn2)C(c2ccccc2)S1	10.1021/acs.jnatprod.7b00317
	CHEMBL4209942	163571	0	None	3	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	335	4	2	4	4.0	Oc1ccccc1C1=NC(Cc2c[nH]cn2)C(c2ccccc2)S1	10.1021/acs.jnatprod.7b00317
	127035065	135977	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	477	13	0	6	5.2	COc1ccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1	10.1039/C4MD00418C
	CHEMBL3736207	135977	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	477	13	0	6	5.2	COc1ccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1	10.1039/C4MD00418C
	44565606	178661	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	411	4	1	3	5.3	COc1cc(-c2ccccc2)ccc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472789	178661	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	411	4	1	3	5.3	COc1cc(-c2ccccc2)ccc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	73389570	161453	33	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at 5-HT2B (unknown origin)Antagonist activity at 5-HT2B (unknown origin)	ChEMBL	378	5	2	4	2.5	Cc1cc(NC(=O)c2cccc(S(=O)(=O)N[C@H]3CCOC3)c2)ccc1F	10.1021/acs.jmedchem.8b00654
	CHEMBL4159471	161453	33	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at 5-HT2B (unknown origin)Antagonist activity at 5-HT2B (unknown origin)	ChEMBL	378	5	2	4	2.5	Cc1cc(NC(=O)c2cccc(S(=O)(=O)N[C@H]3CCOC3)c2)ccc1F	10.1021/acs.jmedchem.8b00654
	2884131	166355	7	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	275	1	3	5	2.2	NC1=NC2(CCCCC2)NC(Nc2cccc(F)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL4286420	166355	7	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	275	1	3	5	2.2	NC1=NC2(CCCCC2)NC(Nc2cccc(F)c2)=N1	10.1021/acsmedchemlett.8b00300
	44155107	7996	3	None	-60	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	359	3	0	6	3.2	CSc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1016/j.bmcl.2010.02.046
	CHEMBL1091207	7996	3	None	-60	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	359	3	0	6	3.2	CSc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1016/j.bmcl.2010.02.046
	4297073	80889	7	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	348	2	0	5	3.4	CCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL215883	80889	7	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	348	2	0	5	3.4	CCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	46933845	15986	0	None	-18	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human 5HT2B receptor assessed as inhibition of 10633-induced calcium mobilization by FLIPR assayAntagonist activity at human 5HT2B receptor assessed as inhibition of 10633-induced calcium mobilization by FLIPR assay	ChEMBL	336	1	1	3	3.9	O=C(NC1CCCCC1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	CHEMBL1224034	15986	0	None	-18	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human 5HT2B receptor assessed as inhibition of 10633-induced calcium mobilization by FLIPR assayAntagonist activity at human 5HT2B receptor assessed as inhibition of 10633-induced calcium mobilization by FLIPR assay	ChEMBL	336	1	1	3	3.9	O=C(NC1CCCCC1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	135753059	190124	5	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	351	4	2	5	2.7	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2ccc(C)c(C)c2)n1	10.1021/acs.jmedchem.1c01759
	CHEMBL5182403	190124	5	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	351	4	2	5	2.7	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2ccc(C)c(C)c2)n1	10.1021/acs.jmedchem.1c01759
	135753074	190514	7	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	341	4	2	5	2.2	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2ccccc2F)n1	10.1021/acs.jmedchem.1c01759
	CHEMBL5187824	190514	7	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	341	4	2	5	2.2	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2ccccc2F)n1	10.1021/acs.jmedchem.1c01759
	135753056	190581	1	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	337	4	2	5	2.4	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2cccc(C)c2)n1	10.1021/acs.jmedchem.1c01759
	CHEMBL5188949	190581	1	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	337	4	2	5	2.4	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2cccc(C)c2)n1	10.1021/acs.jmedchem.1c01759
	156208582	191435	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	351	5	2	5	2.6	CCc1cccc(C(=O)Nc2cc(C)nn2-c2nc(CC)cc(=O)[nH]2)c1	10.1021/acs.jmedchem.1c01759
	CHEMBL5202029	191435	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	351	5	2	5	2.6	CCc1cccc(C(=O)Nc2cc(C)nn2-c2nc(CC)cc(=O)[nH]2)c1	10.1021/acs.jmedchem.1c01759
	3765560	141013	9	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	411	1	0	4	4.4	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(Br)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL384745	141013	9	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	411	1	0	4	4.4	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(Br)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	4518239	80645	6	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	477	3	0	5	5.0	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3OC(F)F)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL215404	80645	6	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	477	3	0	5	5.0	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3OC(F)F)=NN12	10.1016/j.bmcl.2006.06.068
	879244	27988	7	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	271	1	3	5	2.3	Cc1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acsmedchemlett.8b00300
	CHEMBL1373650	27988	7	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	271	1	3	5	2.3	Cc1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acsmedchemlett.8b00300
	4322819	80013	18	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	381	2	0	5	3.8	COc1cccc2c1OC1(CCN(C)CC1)N1N=C(c3ccc(F)cc3)CC21	10.1016/j.bmcl.2006.06.068
	CHEMBL214594	80013	18	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	381	2	0	5	3.8	COc1cccc2c1OC1(CCN(C)CC1)N1N=C(c3ccc(F)cc3)CC21	10.1016/j.bmcl.2006.06.068
	118464421	166739	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	291	1	3	5	2.7	NC1=NC2(CCCCC2)NC(Nc2cccc(Cl)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL4293638	166739	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	291	1	3	5	2.7	NC1=NC2(CCCCC2)NC(Nc2cccc(Cl)c2)=N1	10.1021/acsmedchemlett.8b00300
	44247568	81762	51	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5HT2B receptorAntagonist activity at human 5HT2B receptor	ChEMBL	337	5	0	5	3.0	Cc1cc(OCCN2CCOCC2)nn1-c1ccc2ccccc2c1	10.1021/jm3007323
	CHEMBL2170062	81762	51	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5HT2B receptorAntagonist activity at human 5HT2B receptor	ChEMBL	337	5	0	5	3.0	Cc1cc(OCCN2CCOCC2)nn1-c1ccc2ccccc2c1	10.1021/jm3007323
	44565806	179528	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	388	3	1	3	4.6	O=C(c1ccc(N2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL474839	179528	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	388	3	1	3	4.6	O=C(c1ccc(N2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	2267399	137813	8	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	271	1	3	5	2.3	Cc1ccc(NC2=NC(N)=NC3(CCCCC3)N2)cc1	10.1021/acs.jmedchem.5b01631
	CHEMBL3771373	137813	8	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	271	1	3	5	2.3	Cc1ccc(NC2=NC(N)=NC3(CCCCC3)N2)cc1	10.1021/acs.jmedchem.5b01631
	136928971	137701	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	343	3	3	7	2.5	CCOC(=O)c1cccc(NC2=NC(NC)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770185	137701	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	343	3	3	7	2.5	CCOC(=O)c1cccc(NC2=NC(NC)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	5128094	79447	18	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	333	1	0	4	3.7	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccccc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL212228	79447	18	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	333	1	0	4	3.7	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccccc3)=NN12	10.1016/j.bmcl.2006.06.068
	5167627	79652	7	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	395	3	0	4	5.1	CCCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccccc3Cl)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL213006	79652	7	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	395	3	0	4	5.1	CCCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccccc3Cl)=NN12	10.1016/j.bmcl.2006.06.068
	44416351	79725	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	279	1	0	4	3.4	CC1(C)Oc2ccccc2C2CC(c3ccncc3)=NN21	10.1016/j.bmcl.2006.06.068
	CHEMBL213332	79725	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	279	1	0	4	3.4	CC1(C)Oc2ccccc2C2CC(c3ccncc3)=NN21	10.1016/j.bmcl.2006.06.068
	3802375	79907	7	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	453	3	0	4	5.5	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(C)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL214184	79907	7	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	453	3	0	4	5.5	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(C)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	4657811	80107	8	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	461	1	0	4	5.6	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc4ccccc4c3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL214802	80107	8	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	461	1	0	4	5.6	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc4ccccc4c3)=NN12	10.1016/j.bmcl.2006.06.068
	5165122	80639	20	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	441	2	0	5	4.4	COc1ccc(C2=NN3C(C2)c2cc(Br)ccc2OC32CCN(C)CC2)cc1	10.1016/j.bmcl.2006.06.068
	CHEMBL215386	80639	20	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	441	2	0	5	4.4	COc1ccc(C2=NN3C(C2)c2cc(Br)ccc2OC32CCN(C)CC2)cc1	10.1016/j.bmcl.2006.06.068
	3757038	81061	11	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	401	1	0	5	4.0	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccco3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL215991	81061	11	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	401	1	0	5	4.0	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccco3)=NN12	10.1016/j.bmcl.2006.06.068
	3773677	138456	6	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	441	2	0	5	4.4	COc1ccccc1C1=NN2C(C1)c1cc(Br)ccc1OC21CCN(C)CC1	10.1016/j.bmcl.2006.06.068
	CHEMBL378540	138456	6	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	441	2	0	5	4.4	COc1ccccc1C1=NN2C(C1)c1cc(Br)ccc1OC21CCN(C)CC1	10.1016/j.bmcl.2006.06.068
	3410378	140930	7	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	417	1	0	5	4.5	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3cccs3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL384270	140930	7	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	417	1	0	5	4.5	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3cccs3)=NN12	10.1016/j.bmcl.2006.06.068
	4679720	165424	6	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	471	3	0	6	4.4	COc1ccc(C2=NN3C(C2)c2cc(Br)ccc2OC32CCN(C)CC2)cc1OC	10.1016/j.bmcl.2006.06.068
	CHEMBL425260	165424	6	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	471	3	0	6	4.4	COc1ccc(C2=NN3C(C2)c2cc(Br)ccc2OC32CCN(C)CC2)cc1OC	10.1016/j.bmcl.2006.06.068
	4148445	137773	9	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	291	1	3	5	2.7	NC1=NC2(CCCCC2)NC(Nc2ccc(Cl)cc2)=N1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770873	137773	9	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	291	1	3	5	2.7	NC1=NC2(CCCCC2)NC(Nc2ccc(Cl)cc2)=N1	10.1021/acs.jmedchem.5b01631
	3391669	141309	7	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	479	1	0	4	5.7	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(Cl)c(Cl)c3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL386459	141309	7	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	479	1	0	4	5.7	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(Cl)c(Cl)c3)=NN12	10.1016/j.bmcl.2006.06.068
	44565607	188974	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	427	5	1	5	4.4	CCOc1nc(-c2ccccc2)ncc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL514453	188974	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	427	5	1	5	4.4	CCOc1nc(-c2ccccc2)ncc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565848	178714	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	381	5	1	3	3.7	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473234	178714	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	381	5	1	3	3.7	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565826	178617	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	387	3	1	2	5.2	O=C(C1CCC(c2ccccc2)CC1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472414	178617	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	387	3	1	2	5.2	O=C(C1CCC(c2ccccc2)CC1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44476436	81935	5	None	-7413	2	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alphamethyl5HT-induced intracellular calcium mobilization by Fluo4-based staining methodAntagonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alphamethyl5HT-induced intracellular calcium mobilization by Fluo4-based staining method	ChEMBL	357	3	1	7	1.6	CNc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CN(C)CC3	10.1016/j.bmcl.2012.05.036
	CHEMBL2172186	81935	5	None	-7413	2	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alphamethyl5HT-induced intracellular calcium mobilization by Fluo4-based staining methodAntagonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alphamethyl5HT-induced intracellular calcium mobilization by Fluo4-based staining method	ChEMBL	357	3	1	7	1.6	CNc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CN(C)CC3	10.1016/j.bmcl.2012.05.036
	162674022	182639	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) assessed as inhibition of 5HT-indued response by calcium mobilization assayAntagonist activity at 5-HT2B receptor (unknown origin) assessed as inhibition of 5HT-indued response by calcium mobilization assay	ChEMBL	305	4	1	4	3.5	N#Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
	CHEMBL4796102	182639	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) assessed as inhibition of 5HT-indued response by calcium mobilization assayAntagonist activity at 5-HT2B receptor (unknown origin) assessed as inhibition of 5HT-indued response by calcium mobilization assay	ChEMBL	305	4	1	4	3.5	N#Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
	127037059	136014	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	445	11	0	5	5.6	COc1ccc(CCN(CC/C=C\c2ccccc2)Cc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3736516	136014	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	445	11	0	5	5.6	COc1ccc(CCN(CC/C=C\c2ccccc2)Cc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	10449757	3439	26	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10.1016/j.bmcl.2009.02.126
	190	3439	26	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10.1016/j.bmcl.2009.02.126
	CHEMBL2110371	3439	26	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10.1016/j.bmcl.2009.02.126
	44565639	178737	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	367	4	1	2	5.6	c1ccc(-c2ccc(CN3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	CHEMBL473387	178737	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	367	4	1	2	5.6	c1ccc(-c2ccc(CN3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	44565640	188915	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.2	O=C(c1ccc(-c2ccccc2)cc1)N1CCN(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL513993	188915	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.2	O=C(c1ccc(-c2ccccc2)cc1)N1CCN(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44138039	178709	8	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	363	4	1	2	4.3	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473185	178709	8	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	363	4	1	2	4.3	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565605	189101	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	383	3	1	4	4.0	O=C(c1cnc(-c2ccccc2)nc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL515422	189101	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	383	3	1	4	4.0	O=C(c1cnc(-c2ccccc2)nc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565639	178737	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	367	4	1	2	5.6	c1ccc(-c2ccc(CN3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	CHEMBL473387	178737	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	367	4	1	2	5.6	c1ccc(-c2ccc(CN3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	145989393	166670	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	353	1	3	5	2.9	NC1=NC2(CCCCC2)NC(Nc2cc(F)cc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL4292168	166670	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	353	1	3	5	2.9	NC1=NC2(CCCCC2)NC(Nc2cc(F)cc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
	3473601	139599	6	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	367	1	0	4	4.3	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccccc3Cl)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL380167	139599	6	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	367	1	0	4	4.3	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccccc3Cl)=NN12	10.1016/j.bmcl.2006.06.068
	44565830	179142	2	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	331	3	1	2	4.1	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL474404	179142	2	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	331	3	1	2	4.1	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	57495353	124520	33	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of 5-HT2B (unknown origin) by calcium flux assayInhibition of 5-HT2B (unknown origin) by calcium flux assay	ChEMBL	450	5	1	7	2.9	CCC(=O)N1CC[C@H](Nc2ncnc3c2CN(c2cnc(OC)c(C(F)(F)F)c2)CC3)C1	10.1021/acsmedchemlett.7b00293
	CHEMBL3643413	124520	33	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of 5-HT2B (unknown origin) by calcium flux assayInhibition of 5-HT2B (unknown origin) by calcium flux assay	ChEMBL	450	5	1	7	2.9	CCC(=O)N1CC[C@H](Nc2ncnc3c2CN(c2cnc(OC)c(C(F)(F)F)c2)CC3)C1	10.1021/acsmedchemlett.7b00293
	3400827	79503	10	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	517	3	0	4	6.0	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(Br)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL212457	79503	10	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	517	3	0	4	6.0	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(Br)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	127035062	135928	0	None	6	3	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3735756	135928	0	None	6	3	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	127035066	135898	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	507	14	0	7	5.2	COc1ccc(OC)c(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
	CHEMBL3735434	135898	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	507	14	0	7	5.2	COc1ccc(OC)c(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
	44565828	178619	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	395	3	0	3	5.3	Cn1c(C2CCN(C(=O)c3ccc(-c4ccccc4)cc3)CC2)nc2ccccc21	10.1016/j.bmcl.2009.02.126
	CHEMBL472416	178619	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	395	3	0	3	5.3	Cn1c(C2CCN(C(=O)c3ccc(-c4ccccc4)cc3)CC2)nc2ccccc21	10.1016/j.bmcl.2009.02.126
	145964159	163777	0	None	8	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	273	3	2	4	2.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	CHEMBL4212435	163777	0	None	8	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	273	3	2	4	2.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	44565638	189037	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	417	4	1	3	4.8	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL514934	189037	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	417	4	1	3	4.8	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	3499360	140988	7	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	445	1	0	4	5.1	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3Cl)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL384579	140988	7	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	445	1	0	4	5.1	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3Cl)=NN12	10.1016/j.bmcl.2006.06.068
	104697662	144872	1	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	293	3	2	4	3.3	Clc1cccc(CNc2nc(Cl)nc3[nH]cnc23)c1	10.1021/acs.jmedchem.6b01183
	CHEMBL3914002	144872	1	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	293	3	2	4	3.3	Clc1cccc(CNc2nc(Cl)nc3[nH]cnc23)c1	10.1021/acs.jmedchem.6b01183
	11536299	182704	6	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilizationAntagonist activity at 5-HT2B receptor (unknown origin) expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization	ChEMBL	266	3	1	3	3.3	O=c1cc(CCc2ccccc2)oc2cccc(O)c12	10.1016/j.bmcl.2014.02.029
	CHEMBL479683	182704	6	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilizationAntagonist activity at 5-HT2B receptor (unknown origin) expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization	ChEMBL	266	3	1	3	3.3	O=c1cc(CCc2ccccc2)oc2cccc(O)c12	10.1016/j.bmcl.2014.02.029
	109052212	161997	1	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at 5-HT2B (unknown origin)Antagonist activity at 5-HT2B (unknown origin)	ChEMBL	340	4	2	2	4.1	O=C(Nc1ccc(F)cc1)c1cccc(C(=O)NC2CCCCC2)c1	10.1021/acs.jmedchem.8b00654
	CHEMBL4168125	161997	1	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at 5-HT2B (unknown origin)Antagonist activity at 5-HT2B (unknown origin)	ChEMBL	340	4	2	2	4.1	O=C(Nc1ccc(F)cc1)c1cccc(C(=O)NC2CCCCC2)c1	10.1021/acs.jmedchem.8b00654
	44565607	188974	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	427	5	1	5	4.4	CCOc1nc(-c2ccccc2)ncc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL514453	188974	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	427	5	1	5	4.4	CCOc1nc(-c2ccccc2)ncc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	3442850	168994	20	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	411	1	0	4	4.4	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL443570	168994	20	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	411	1	0	4	4.4	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3)=NN12	10.1016/j.bmcl.2006.06.068
	4895014	79590	7	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	334	1	0	5	3.0	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL212780	79590	7	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	334	1	0	5	3.0	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	44565824	178713	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	465	4	1	3	6.1	O=C(c1ccc(-c2ccc(OC(F)(F)F)cc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473214	178713	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	465	4	1	3	6.1	O=C(c1ccc(-c2ccc(OC(F)(F)F)cc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565848	178714	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	381	5	1	3	3.7	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473234	178714	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	381	5	1	3	3.7	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	12611598	60116	3	None	-	0	Rat	7.0	pKd	=	7	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	181	3	2	3	1.3	COc1ccc(O)c(CC(C)N)c1	10.1021/jm00183a006
	CHEMBL175205	60116	3	None	-	0	Rat	7.0	pKd	=	7	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	181	3	2	3	1.3	COc1ccc(O)c(CC(C)N)c1	10.1021/jm00183a006
	221	3435	63	None	-	3	Rat	8.0	pKd	=	8.0	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	10.1021/jm00006a001
	3277600	3435	63	None	-	3	Rat	8.0	pKd	=	8.0	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	10.1021/jm00006a001
	CHEMBL323356	3435	63	None	-	3	Rat	8.0	pKd	=	8.0	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	10.1021/jm00006a001
	44385952	61879	5	None	-	0	Rat	7.9	pKd	=	7.9	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	195	3	2	3	1.6	COc1cc(C)c(O)cc1CC(C)N	10.1021/jm00183a006
	CHEMBL177800	61879	5	None	-	0	Rat	7.9	pKd	=	7.9	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	195	3	2	3	1.6	COc1cc(C)c(O)cc1CC(C)N	10.1021/jm00183a006
	135398737	944	89	None	-	36	Rat	6.9	pKd	=	6.9	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
	38	944	89	None	-	36	Rat	6.9	pKd	=	6.9	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
	722	944	89	None	-	36	Rat	6.9	pKd	=	6.9	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
	CHEMBL42	944	89	None	-	36	Rat	6.9	pKd	=	6.9	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
	DB00363	944	89	None	-	36	Rat	6.9	pKd	=	6.9	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
	10022745	119464	0	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	381	5	1	4	3.5	CCc1c(C)[nH]c2c1C(=O)CC(CN1CCN(c3ccccc3OC)CC1)C2	10.1021/jm011014y
	CHEMBL349832	119464	0	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	381	5	1	4	3.5	CCc1c(C)[nH]c2c1C(=O)CC(CN1CCN(c3ccccc3OC)CC1)C2	10.1021/jm011014y
	44327167	9288	0	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	371	4	0	4	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2sccc21	10.1021/jm011014y
	CHEMBL111393	9288	0	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	371	4	0	4	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2sccc21	10.1021/jm011014y
	CHEMBL544319	9288	0	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	371	4	0	4	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2sccc21	10.1021/jm011014y
	12611606	60059	7	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	181	3	2	3	1.3	COc1ccc(CC(C)N)cc1O	10.1021/jm00183a006
	CHEMBL174723	60059	7	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	181	3	2	3	1.3	COc1ccc(CC(C)N)cc1O	10.1021/jm00183a006
	12611609	60115	3	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	167	3	2	3	0.9	COc1ccc(O)c(CCN)c1	10.1021/jm00183a006
	CHEMBL175204	60115	3	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	167	3	2	3	0.9	COc1ccc(O)c(CCN)c1	10.1021/jm00183a006
	12611617	60036	3	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	195	4	1	3	1.5	COc1ccc(O)c(CCN(C)C)c1	10.1021/jm00183a006
	CHEMBL174563	60036	3	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	195	4	1	3	1.5	COc1ccc(O)c(CCN(C)C)c1	10.1021/jm00183a006
	12611598	60116	3	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	181	3	2	3	1.3	COc1ccc(O)c(CC(C)N)c1	10.1021/jm00183a006
	CHEMBL175205	60116	3	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	181	3	2	3	1.3	COc1ccc(O)c(CC(C)N)c1	10.1021/jm00183a006
	10356829	59379	0	None	-	0	Rat	7.8	pKd	=	7.8	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	289	2	2	4	4.3	Cc1cc(NC(=O)Nc2ccc3sccc3c2)sn1	10.1021/jm00006a001
	CHEMBL172269	59379	0	None	-	0	Rat	7.8	pKd	=	7.8	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	289	2	2	4	4.3	Cc1cc(NC(=O)Nc2ccc3sccc3c2)sn1	10.1021/jm00006a001
	10693836	9247	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	428	8	0	5	4.3	O=C(CCCN1CCN(CCC2CCc3sccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL111189	9247	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	428	8	0	5	4.3	O=C(CCCN1CCN(CCC2CCc3sccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL545488	9247	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	428	8	0	5	4.3	O=C(CCCN1CCN(CCC2CCc3sccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	10715378	15343	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	389	4	1	4	3.7	COc1ccccc1N1CCN(CC2CC(=O)c3c([nH]c4ccccc34)C2)CC1	10.1021/jm011014y
	CHEMBL121744	15343	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	389	4	1	4	3.7	COc1ccccc1N1CCN(CC2CC(=O)c3c([nH]c4ccccc34)C2)CC1	10.1021/jm011014y
	9979654	206182	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	422	8	0	4	4.2	O=C(CCCN1CCN(CCC2CCc3ccccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL96781	206182	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	422	8	0	4	4.2	O=C(CCCN1CCN(CCC2CCc3ccccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	12611613	60138	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	209	4	1	3	1.9	COc1ccc(O)c(CC(C)N(C)C)c1	10.1021/jm00183a006
	CHEMBL175328	60138	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	209	4	1	3	1.9	COc1ccc(O)c(CC(C)N(C)C)c1	10.1021/jm00183a006
	10473483	8563	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	356	4	0	5	3.3	COc1ccccc1N1CCN(CC2CC(=O)c3ccsc3C2)CC1	10.1021/jm011014y
	CHEMBL109528	8563	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	356	4	0	5	3.3	COc1ccccc1N1CCN(CC2CC(=O)c3ccsc3C2)CC1	10.1021/jm011014y
	CHEMBL544318	8563	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	356	4	0	5	3.3	COc1ccccc1N1CCN(CC2CC(=O)c3ccsc3C2)CC1	10.1021/jm011014y
	135398737	944	89	None	-	36	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm011014y
	38	944	89	None	-	36	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm011014y
	722	944	89	None	-	36	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm011014y
	CHEMBL42	944	89	None	-	36	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm011014y
	DB00363	944	89	None	-	36	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm011014y
	10710246	120614	0	None	-	0	Rat	5.7	pKd	=	5.7	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	312	3	0	6	1.6	O=C1CC(CN2CCN(c3ncccn3)CC2)Cc2occc21	10.1021/jm0009890
	CHEMBL357517	120614	0	None	-	0	Rat	5.7	pKd	=	5.7	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	312	3	0	6	1.6	O=C1CC(CN2CCN(c3ncccn3)CC2)Cc2occc21	10.1021/jm0009890
	10338282	34464	1	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B) receptor	ChEMBL	355	4	0	4	3.8	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2occc21	10.1021/jm0009890
	CHEMBL143022	34464	1	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B) receptor	ChEMBL	355	4	0	4	3.8	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2occc21	10.1021/jm0009890
	10338282	34464	1	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	355	4	0	4	3.8	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2occc21	10.1021/jm011014y
	CHEMBL143022	34464	1	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	355	4	0	4	3.8	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2occc21	10.1021/jm011014y
	11760018	53084	0	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	354	5	0	5	3.2	COc1ccccc1N1CCN(CCC2CCc3occc3C2=O)CC1	10.1021/jm011014y
	CHEMBL160019	53084	0	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	354	5	0	5	3.2	COc1ccccc1N1CCN(CCC2CCc3occc3C2=O)CC1	10.1021/jm011014y
	44326982	8571	0	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	351	4	0	3	4.1	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)c2ccccc21	10.1021/jm011014y
	CHEMBL109548	8571	0	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	351	4	0	3	4.1	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)c2ccccc21	10.1021/jm011014y
	CHEMBL545727	8571	0	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	351	4	0	3	4.1	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)c2ccccc21	10.1021/jm011014y
	10090486	52991	0	None	-	0	Rat	6.6	pKd	=	6.6	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	369	5	0	4	4.1	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3occc3C2=O)CC1	10.1021/jm011014y
	CHEMBL159929	52991	0	None	-	0	Rat	6.6	pKd	=	6.6	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	369	5	0	4	4.1	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3occc3C2=O)CC1	10.1021/jm011014y
	10090424	34474	1	None	-	0	Rat	6.6	pKd	=	6.6	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	368	3	0	5	4.2	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2occc21	10.1021/jm0009890
	CHEMBL143027	34474	1	None	-	0	Rat	6.6	pKd	=	6.6	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	368	3	0	5	4.2	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2occc21	10.1021/jm0009890
	10090424	34474	1	None	-	0	Rat	6.6	pKd	=	6.6	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	368	3	0	5	4.2	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2occc21	10.1021/jm011014y
	CHEMBL143027	34474	1	None	-	0	Rat	6.6	pKd	=	6.6	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	368	3	0	5	4.2	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2occc21	10.1021/jm011014y
	12611604	60126	3	None	-	0	Rat	5.6	pKd	=	5.6	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	181	3	2	3	1.3	COc1ccc(CC(C)N)c(O)c1	10.1021/jm00183a006
	CHEMBL175272	60126	3	None	-	0	Rat	5.6	pKd	=	5.6	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	181	3	2	3	1.3	COc1ccc(CC(C)N)c(O)c1	10.1021/jm00183a006
	10645469	110068	0	None	-	0	Rat	5.6	pKd	=	5.6	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	414	7	0	5	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccsc3C2)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL325253	110068	0	None	-	0	Rat	5.6	pKd	=	5.6	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	414	7	0	5	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccsc3C2)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL542428	110068	0	None	-	0	Rat	5.6	pKd	=	5.6	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	414	7	0	5	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccsc3C2)CC1)c1ccc(F)cc1	10.1021/jm011014y
	12611615	60016	1	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	285	7	0	3	3.4	COc1ccc(OCc2ccccc2)c(CCN(C)C)c1	10.1021/jm00183a006
	CHEMBL174449	60016	1	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	285	7	0	3	3.4	COc1ccc(OCc2ccccc2)c(CCN(C)C)c1	10.1021/jm00183a006
	12611617	60036	3	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	195	4	1	3	1.5	COc1ccc(O)c(CCN(C)C)c1	10.1021/jm00183a006
	CHEMBL174563	60036	3	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	195	4	1	3	1.5	COc1ccc(O)c(CCN(C)C)c1	10.1021/jm00183a006
	10024430	205879	0	None	-	0	Rat	7.5	pKd	=	7.5	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	408	8	0	4	3.9	O=C(CCCN1CCN(CCC2Cc3ccccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL95098	205879	0	None	-	0	Rat	7.5	pKd	=	7.5	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	408	8	0	4	3.9	O=C(CCCN1CCN(CCC2Cc3ccccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	12611613	60138	0	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	209	4	1	3	1.9	COc1ccc(O)c(CC(C)N(C)C)c1	10.1021/jm00183a006
	CHEMBL175328	60138	0	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	209	4	1	3	1.9	COc1ccc(O)c(CC(C)N(C)C)c1	10.1021/jm00183a006
	44327153	108723	0	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonistic activity on 5-hydroxytryptamine 2B receptor of Rat stomach fundus;ND is not determinedAntagonistic activity on 5-hydroxytryptamine 2B receptor of Rat stomach fundus;ND is not determined	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccsc3C2=O)CC1	10.1021/jm011014y
	CHEMBL321682	108723	0	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonistic activity on 5-hydroxytryptamine 2B receptor of Rat stomach fundus;ND is not determinedAntagonistic activity on 5-hydroxytryptamine 2B receptor of Rat stomach fundus;ND is not determined	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccsc3C2=O)CC1	10.1021/jm011014y
	CHEMBL558817	108723	0	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonistic activity on 5-hydroxytryptamine 2B receptor of Rat stomach fundus;ND is not determinedAntagonistic activity on 5-hydroxytryptamine 2B receptor of Rat stomach fundus;ND is not determined	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccsc3C2=O)CC1	10.1021/jm011014y
	10804995	35353	0	None	-	0	Rat	5.5	pKd	=	5.5	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	311	3	0	5	2.2	O=C1CC(CN2CCN(c3ccccn3)CC2)Cc2occc21	10.1021/jm0009890
	CHEMBL143937	35353	0	None	-	0	Rat	5.5	pKd	=	5.5	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	311	3	0	5	2.2	O=C1CC(CN2CCN(c3ccccn3)CC2)Cc2occc21	10.1021/jm0009890
	10804995	35353	0	None	-	0	Rat	5.5	pKd	=	5.5	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	311	3	0	5	2.2	O=C1CC(CN2CCN(c3ccccn3)CC2)Cc2occc21	10.1021/jm011014y
	CHEMBL143937	35353	0	None	-	0	Rat	5.5	pKd	=	5.5	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	311	3	0	5	2.2	O=C1CC(CN2CCN(c3ccccn3)CC2)Cc2occc21	10.1021/jm011014y
	197139	24868	20	None	-	0	Rat	5.5	pKd	=	5.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	181	3	2	3	1.3	COc1cc(CC(C)N)ccc1O	10.1021/jm00183a006
	CHEMBL1347	24868	20	None	-	0	Rat	5.5	pKd	=	5.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	181	3	2	3	1.3	COc1cc(CC(C)N)ccc1O	10.1021/jm00183a006
	12611606	60059	7	None	-	0	Rat	5.5	pKd	=	5.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	181	3	2	3	1.3	COc1ccc(CC(C)N)cc1O	10.1021/jm00183a006
	CHEMBL174723	60059	7	None	-	0	Rat	5.5	pKd	=	5.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	181	3	2	3	1.3	COc1ccc(CC(C)N)cc1O	10.1021/jm00183a006
	12611596	59985	6	None	-	0	Rat	7.4	pKd	=	7.4	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	195	3	2	3	1.6	COc1cc(CC(C)N)c(O)cc1C	10.1021/jm00183a006
	CHEMBL174380	59985	6	None	-	0	Rat	7.4	pKd	=	7.4	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	195	3	2	3	1.6	COc1cc(CC(C)N)c(O)cc1C	10.1021/jm00183a006
	12611615	60016	1	None	-	0	Rat	5.4	pKd	=	5.4	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	285	7	0	3	3.4	COc1ccc(OCc2ccccc2)c(CCN(C)C)c1	10.1021/jm00183a006
	CHEMBL174449	60016	1	None	-	0	Rat	5.4	pKd	=	5.4	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	285	7	0	3	3.4	COc1ccc(OCc2ccccc2)c(CCN(C)C)c1	10.1021/jm00183a006
	9951008	204671	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	365	5	0	3	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3ccccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL87717	204671	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	365	5	0	3	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3ccccc3C2=O)CC1	10.1021/jm011014y
	126769	204323	35	None	-	0	Rat	7.4	pKd	=	7.4	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	266	2	2	3	3.2	Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc21	10.1021/jm00006a001
	CHEMBL536255	204323	35	None	-	0	Rat	7.4	pKd	=	7.4	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	266	2	2	3	3.2	Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc21	10.1021/jm00006a001
	CHEMBL85194	204323	35	None	-	0	Rat	7.4	pKd	=	7.4	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	266	2	2	3	3.2	Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc21	10.1021/jm00006a001
	9930475	204567	0	None	-	0	Rat	7.4	pKd	=	7.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	393	5	0	3	4.9	O=C(c1ccc(F)cc1)C1CCN(CCC2CCCc3ccccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL87026	204567	0	None	-	0	Rat	7.4	pKd	=	7.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	393	5	0	3	4.9	O=C(c1ccc(F)cc1)C1CCN(CCC2CCCc3ccccc3C2=O)CC1	10.1021/jm011014y
	10597019	34044	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	398	7	0	5	3.4	O=C(CCCN1CCN(CC2CC(=O)c3ccoc3C2)CC1)c1ccc(F)cc1	10.1021/jm0009890
	CHEMBL142668	34044	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	398	7	0	5	3.4	O=C(CCCN1CCN(CC2CC(=O)c3ccoc3C2)CC1)c1ccc(F)cc1	10.1021/jm0009890
	10597019	34044	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	398	7	0	5	3.4	O=C(CCCN1CCN(CC2CC(=O)c3ccoc3C2)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL142668	34044	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	398	7	0	5	3.4	O=C(CCCN1CCN(CC2CC(=O)c3ccoc3C2)CC1)c1ccc(F)cc1	10.1021/jm011014y
	10249506	8717	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL109673	8717	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL544091	8717	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm011014y
	11141324	52813	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	307	3	0	4	2.6	O=C1CC(CN2CCN(c3ccccn3)CC2)c2ccccc21	10.1021/jm011014y
	CHEMBL159771	52813	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	307	3	0	4	2.6	O=C1CC(CN2CCN(c3ccccn3)CC2)c2ccccc21	10.1021/jm011014y
	9866660	113923	2	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	417	3	1	4	5.1	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2[nH]c3ccccc3c21	10.1021/jm011014y
	CHEMBL333174	113923	2	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	417	3	1	4	5.1	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2[nH]c3ccccc3c21	10.1021/jm011014y
	10061837	120228	0	None	-	0	Rat	7.3	pKd	=	7.3	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	273	2	2	4	3.8	Cc1cc(NC(=O)Nc2ccc3sccc3c2)on1	10.1021/jm00006a001
	CHEMBL354951	120228	0	None	-	0	Rat	7.3	pKd	=	7.3	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	273	2	2	4	3.8	Cc1cc(NC(=O)Nc2ccc3sccc3c2)on1	10.1021/jm00006a001
	10022781	56759	0	None	-	0	Rat	6.3	pKd	=	6.3	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	382	4	0	5	4.6	O=C1c2ccoc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm011014y
	CHEMBL164471	56759	0	None	-	0	Rat	6.3	pKd	=	6.3	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	382	4	0	5	4.6	O=C1c2ccoc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm011014y
	44326751	108128	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	384	3	0	5	4.7	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2sccc21	10.1021/jm011014y
	CHEMBL320572	108128	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	384	3	0	5	4.7	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2sccc21	10.1021/jm011014y
	CHEMBL539544	108128	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	384	3	0	5	4.7	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2sccc21	10.1021/jm011014y
	10693017	33615	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	412	8	0	5	3.8	O=C(CCCCN1CCN(CC2CC(=O)c3ccoc3C2)CC1)c1ccc(F)cc1	10.1021/jm0009890
	CHEMBL142316	33615	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	412	8	0	5	3.8	O=C(CCCCN1CCN(CC2CC(=O)c3ccoc3C2)CC1)c1ccc(F)cc1	10.1021/jm0009890
	10367486	9204	1	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	398	4	0	5	5.0	O=C1c2ccsc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm011014y
	CHEMBL110948	9204	1	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	398	4	0	5	5.0	O=C1c2ccsc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm011014y
	CHEMBL543613	9204	1	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	398	4	0	5	5.0	O=C1c2ccsc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm011014y
	10693017	33615	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	412	8	0	5	3.8	O=C(CCCCN1CCN(CC2CC(=O)c3ccoc3C2)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL142316	33615	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	412	8	0	5	3.8	O=C(CCCCN1CCN(CC2CC(=O)c3ccoc3C2)CC1)c1ccc(F)cc1	10.1021/jm011014y
	10069784	14814	1	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	404	4	1	3	4.6	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2[nH]c3ccccc3c21	10.1021/jm011014y
	CHEMBL120903	14814	1	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	404	4	1	3	4.6	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2[nH]c3ccccc3c21	10.1021/jm011014y
	15021876	102935	0	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	365	4	0	3	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2ccccc21	10.1021/jm011014y
	CHEMBL308480	102935	0	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	365	4	0	3	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2ccccc21	10.1021/jm011014y
	10809188	9185	0	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	370	5	0	5	3.7	COc1ccccc1N1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL110847	9185	0	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	370	5	0	5	3.7	COc1ccccc1N1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL540822	9185	0	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	370	5	0	5	3.7	COc1ccccc1N1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm011014y
	10497359	121223	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	340	4	0	5	2.9	COc1ccccc1N1CCN(CC2CC(=O)c3ccoc3C2)CC1	10.1021/jm0009890
	CHEMBL358895	121223	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	340	4	0	5	2.9	COc1ccccc1N1CCN(CC2CC(=O)c3ccoc3C2)CC1	10.1021/jm0009890
	10497359	121223	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	340	4	0	5	2.9	COc1ccccc1N1CCN(CC2CC(=O)c3ccoc3C2)CC1	10.1021/jm011014y
	CHEMBL358895	121223	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	340	4	0	5	2.9	COc1ccccc1N1CCN(CC2CC(=O)c3ccoc3C2)CC1	10.1021/jm011014y
	197139	24868	20	None	-	0	Rat	5.2	pKd	=	5.2	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	181	3	2	3	1.3	COc1cc(CC(C)N)ccc1O	10.1021/jm00183a006
	CHEMBL1347	24868	20	None	-	0	Rat	5.2	pKd	=	5.2	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	181	3	2	3	1.3	COc1cc(CC(C)N)ccc1O	10.1021/jm00183a006
	11023903	52475	0	None	-	0	Rat	5.2	pKd	=	5.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	327	3	0	5	2.7	O=C1CC(CN2CCN(c3ccccn3)CC2)Cc2sccc21	10.1021/jm011014y
	CHEMBL159466	52475	0	None	-	0	Rat	5.2	pKd	=	5.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	327	3	0	5	2.7	O=C1CC(CN2CCN(c3ccccn3)CC2)Cc2sccc21	10.1021/jm011014y
	10015954	164687	2	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	270	2	2	4	3.1	Cc1cc(NC(=O)Nc2ccc3c(ccn3C)c2)on1	10.1021/jm00006a001
	CHEMBL422923	164687	2	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	270	2	2	4	3.1	Cc1cc(NC(=O)Nc2ccc3c(ccn3C)c2)on1	10.1021/jm00006a001
	9886130	204704	0	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	379	5	0	3	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL87943	204704	0	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	379	5	0	3	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm011014y
	10622347	54119	0	None	-	0	Rat	5.1	pKd	=	5.1	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	426	8	0	4	4.0	O=C(CCCN1CCN(CCC2Cc3cc(F)ccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL160907	54119	0	None	-	0	Rat	5.1	pKd	=	5.1	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	426	8	0	4	4.0	O=C(CCCN1CCN(CCC2Cc3cc(F)ccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	10044334	205392	13	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	364	5	0	4	3.7	COc1ccccc1N1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL92145	205392	13	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	364	5	0	4	3.7	COc1ccccc1N1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm011014y
	12611596	59985	6	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	195	3	2	3	1.6	COc1cc(CC(C)N)c(O)cc1C	10.1021/jm00183a006
	CHEMBL174380	59985	6	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	195	3	2	3	1.6	COc1cc(CC(C)N)c(O)cc1C	10.1021/jm00183a006
	44385952	61879	5	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	195	3	2	3	1.6	COc1cc(C)c(O)cc1CC(C)N	10.1021/jm00183a006
	CHEMBL177800	61879	5	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	195	3	2	3	1.6	COc1cc(C)c(O)cc1CC(C)N	10.1021/jm00183a006
	9951964	204635	0	None	-	0	Rat	6.1	pKd	=	6.1	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	383	5	0	3	4.3	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3cc(F)ccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL87458	204635	0	None	-	0	Rat	6.1	pKd	=	6.1	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	383	5	0	3	4.3	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3cc(F)ccc3C2=O)CC1	10.1021/jm011014y
	12611609	60115	3	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	167	3	2	3	0.9	COc1ccc(O)c(CCN)c1	10.1021/jm00183a006
	CHEMBL175204	60115	3	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	167	3	2	3	0.9	COc1ccc(O)c(CCN)c1	10.1021/jm00183a006
	2148	3827	109	None	-	4	Rat	5.1	pKd	=	5.1	Functional	Antagonistic activity of corresponding methoxy compound against serotonin 5-HT receptorAntagonistic activity of corresponding methoxy compound against serotonin 5-HT receptor	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1021/jm00183a006
	2150	3827	109	None	-	4	Rat	5.1	pKd	=	5.1	Functional	Antagonistic activity of corresponding methoxy compound against serotonin 5-HT receptorAntagonistic activity of corresponding methoxy compound against serotonin 5-HT receptor	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1021/jm00183a006
	2784	3827	109	None	-	4	Rat	5.1	pKd	=	5.1	Functional	Antagonistic activity of corresponding methoxy compound against serotonin 5-HT receptorAntagonistic activity of corresponding methoxy compound against serotonin 5-HT receptor	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1021/jm00183a006
	5610	3827	109	None	-	4	Rat	5.1	pKd	=	5.1	Functional	Antagonistic activity of corresponding methoxy compound against serotonin 5-HT receptorAntagonistic activity of corresponding methoxy compound against serotonin 5-HT receptor	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1021/jm00183a006
	CHEMBL11608	3827	109	None	-	4	Rat	5.1	pKd	=	5.1	Functional	Antagonistic activity of corresponding methoxy compound against serotonin 5-HT receptorAntagonistic activity of corresponding methoxy compound against serotonin 5-HT receptor	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1021/jm00183a006
	DB08841	3827	109	None	-	4	Rat	5.1	pKd	=	5.1	Functional	Antagonistic activity of corresponding methoxy compound against serotonin 5-HT receptorAntagonistic activity of corresponding methoxy compound against serotonin 5-HT receptor	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1021/jm00183a006
	10022123	53035	0	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	371	5	0	4	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3sccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL159969	53035	0	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	371	5	0	4	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3sccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL92673	53035	0	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	371	5	0	4	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3sccc3C2=O)CC1	10.1021/jm011014y
	10544858	169461	0	None	-	0	Rat	7.0	pKd	=	7.0	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	336	4	0	4	3.2	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc32)CC1	10.1021/jm011014y
	CHEMBL444269	169461	0	None	-	0	Rat	7.0	pKd	=	7.0	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	336	4	0	4	3.2	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc32)CC1	10.1021/jm011014y
	CHEMBL542181	169461	0	None	-	0	Rat	7.0	pKd	=	7.0	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	336	4	0	4	3.2	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc32)CC1	10.1021/jm011014y
	11121409	56108	0	None	-	0	Rat	7.0	pKd	=	7.0	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	341	4	0	5	3.1	O=C1c2ccsc2CCC1CCN1CCN(c2ccccn2)CC1	10.1021/jm011014y
	CHEMBL163180	56108	0	None	-	0	Rat	7.0	pKd	=	7.0	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	341	4	0	5	3.1	O=C1c2ccsc2CCC1CCN1CCN(c2ccccn2)CC1	10.1021/jm011014y
	10710246	120614	0	None	-	0	Rat	6.0	pKd	=	6.0	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	312	3	0	6	1.6	O=C1CC(CN2CCN(c3ncccn3)CC2)Cc2occc21	10.1021/jm011014y
	CHEMBL357517	120614	0	None	-	0	Rat	6.0	pKd	=	6.0	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	312	3	0	6	1.6	O=C1CC(CN2CCN(c3ncccn3)CC2)Cc2occc21	10.1021/jm011014y
	10017554	4275	25	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonistic activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligandAntagonistic activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligand	ChEMBL	297	2	1	3	2.2	CC(N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm960199j
	CHEMBL101008	4275	25	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonistic activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligandAntagonistic activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligand	ChEMBL	297	2	1	3	2.2	CC(N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm960199j
	10017554	4275	25	None	-	0	Human	8.8	pKi	=	8.8	Functional	Agonistic activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]-5-HT as radioligandAgonistic activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]-5-HT as radioligand	ChEMBL	297	2	1	3	2.2	CC(N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm960199j
	CHEMBL101008	4275	25	None	-	0	Human	8.8	pKi	=	8.8	Functional	Agonistic activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]-5-HT as radioligandAgonistic activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]-5-HT as radioligand	ChEMBL	297	2	1	3	2.2	CC(N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm960199j
	134143752	150116	0	None	-	0	Human	8.7	pKi	=	8.7	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	447	7	3	9	1.9	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3955519	150116	0	None	-	0	Human	8.7	pKi	=	8.7	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	447	7	3	9	1.9	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	49836525	18619	0	None	-	0	Human	8.0	pKi	=	8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	375	2	1	2	4.4	CC1(C(=O)O)CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1278202	18619	0	None	-	0	Human	8.0	pKi	=	8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	375	2	1	2	4.4	CC1(C(=O)O)CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	49836524	18618	0	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	361	2	1	2	4.0	O=C(O)C1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1278201	18618	0	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	361	2	1	2	4.0	O=C(O)C1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	46933091	15587	0	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	400	4	1	5	3.1	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3cc(Cl)nc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	CHEMBL1222695	15587	0	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	400	4	1	5	3.1	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3cc(Cl)nc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	49836526	18461	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	375	3	1	2	4.4	O=C(O)CC1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1276859	18461	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	375	3	1	2	4.4	O=C(O)CC1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	49836411	18538	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	389	3	1	2	4.8	O=C(O)CC1CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	CHEMBL1277585	18538	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	389	3	1	2	4.8	O=C(O)CC1CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	44516817	57358	4	None	-1023	2	Human	6.0	pKi	=	6.0	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilizationAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization	ChEMBL	316	3	1	6	2.2	CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2011.01.038
	CHEMBL1668584	57358	4	None	-1023	2	Human	6.0	pKi	=	6.0	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilizationAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization	ChEMBL	316	3	1	6	2.2	CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2011.01.038
	185	3943	54	None	-	1	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	10.1021/jm100856p
	5311271	3943	54	None	-	1	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	10.1021/jm100856p
	CHEMBL74355	3943	54	None	-	1	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	10.1021/jm100856p
	DB16351	3943	54	None	-	1	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	10.1021/jm100856p
	49836412	18537	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	375	2	1	2	4.4	O=C(O)[C@@H]1CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1277584	18537	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	375	2	1	2	4.4	O=C(O)[C@@H]1CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	49836294	18592	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	387	2	0	3	4.4	COC(=O)C1=CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1278020	18592	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	387	2	0	3	4.4	COC(=O)C1=CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	49836522	18607	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	376	2	2	3	3.0	O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CCN1	10.1021/jm100856p
	CHEMBL1278113	18607	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	376	2	2	3	3.0	O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CCN1	10.1021/jm100856p
	52944115	18610	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	291	1	0	1	4.2	CN(C)C1CC[C@]2(Cc3ccccc3Cc3ccccc32)C1	10.1021/jm100856p
	CHEMBL1278116	18610	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	291	1	0	1	4.2	CN(C)C1CC[C@]2(Cc3ccccc3Cc3ccccc32)C1	10.1021/jm100856p
	49833883	15585	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	394	4	1	5	3.1	Cc1nc2n(c1C)Cc1ccccc1C=C2N1CCN(CC(C)(C)C(=O)O)CC1	10.1016/j.bmcl.2010.07.029
	CHEMBL1222693	15585	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	394	4	1	5	3.1	Cc1nc2n(c1C)Cc1ccccc1C=C2N1CCN(CC(C)(C)C(=O)O)CC1	10.1016/j.bmcl.2010.07.029
	44156754	6432	3	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometry	ChEMBL	342	3	1	6	2.5	CNc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1021/jm100350r
	CHEMBL1082763	6432	3	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometry	ChEMBL	342	3	1	6	2.5	CNc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1021/jm100350r
	49836299	18557	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	375	2	1	2	4.4	O=C(O)C1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	CHEMBL1277770	18557	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	375	2	1	2	4.4	O=C(O)C1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	49833886	15602	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	396	5	1	6	2.5	COc1cnc2n1Cc1ccccc1C=C2N1CCN(CC(C)(C)C(=O)O)CC1	10.1016/j.bmcl.2010.07.029
	CHEMBL1222764	15602	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	396	5	1	6	2.5	COc1cnc2n1Cc1ccccc1C=C2N1CCN(CC(C)(C)C(=O)O)CC1	10.1016/j.bmcl.2010.07.029
	49836639	18497	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	377	2	1	3	4.6	O=C(O)C1CCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)CC1	10.1021/jm100856p
	CHEMBL1277216	18497	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	377	2	1	3	4.6	O=C(O)C1CCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)CC1	10.1021/jm100856p
	46933089	15557	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	366	4	1	5	2.5	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3ccnc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	CHEMBL1222554	15557	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	366	4	1	5	2.5	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3ccnc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	46867519	6430	3	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometry	ChEMBL	342	3	1	6	2.5	CNc1nn2cc3c(nc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1021/jm100350r
	CHEMBL1082761	6430	3	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometry	ChEMBL	342	3	1	6	2.5	CNc1nn2cc3c(nc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1021/jm100350r
	44156752	6502	3	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometry	ChEMBL	342	3	1	6	2.4	CNc1nn2c3c(c(C)nc2c1S(=O)(=O)c1ccccc1)CCC3	10.1021/jm100350r
	CHEMBL1083075	6502	3	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometry	ChEMBL	342	3	1	6	2.4	CNc1nn2c3c(c(C)nc2c1S(=O)(=O)c1ccccc1)CCC3	10.1021/jm100350r
	10609802	106708	2	None	-	1	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]- rauwolscine radioligandAntagonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]- rauwolscine radioligand	ChEMBL	235	3	1	4	1.1	COc1c2c(c(CCN)c3c1OCC3)CCO2	10.1021/jm970219x
	CHEMBL316527	106708	2	None	-	1	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]- rauwolscine radioligandAntagonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]- rauwolscine radioligand	ChEMBL	235	3	1	4	1.1	COc1c2c(c(CCN)c3c1OCC3)CCO2	10.1021/jm970219x
	155531067	171053	0	None	-	1	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assayAntagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assay	ChEMBL	369	7	3	6	3.3	Nc1nc(NCCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
	CHEMBL4465512	171053	0	None	-	1	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assayAntagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assay	ChEMBL	369	7	3	6	3.3	Nc1nc(NCCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
	134141831	146154	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	405	6	4	8	1.4	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3923870	146154	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	405	6	4	8	1.4	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	49833882	15584	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	392	3	1	5	3.0	O=C(O)C1CCC(N2CCN(C3=Cc4ccccc4Cn4ccnc43)CC2)CC1	10.1016/j.bmcl.2010.07.029
	CHEMBL1222692	15584	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	392	3	1	5	3.0	O=C(O)C1CCC(N2CCN(C3=Cc4ccccc4Cn4ccnc43)CC2)CC1	10.1016/j.bmcl.2010.07.029
	46933090	15600	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	400	4	1	5	3.1	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3c(Cl)cnc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	CHEMBL1222762	15600	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	400	4	1	5	3.1	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3c(Cl)cnc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	49836635	18480	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	359	2	1	2	4.0	O=C(O)C=C1CN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1277035	18480	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	359	2	1	2	4.0	O=C(O)C=C1CN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	49836409	18549	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	391	2	2	3	3.5	O=C(O)C1(O)CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	CHEMBL1277679	18549	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	391	2	2	3	3.5	O=C(O)C1(O)CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	49836300	18556	0	None	-	0	Human	8.5	pKi	=	8.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	389	2	1	2	4.8	CC1(C(=O)O)CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	CHEMBL1277769	18556	0	None	-	0	Human	8.5	pKi	=	8.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	389	2	1	2	4.8	CC1(C(=O)O)CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	134154065	151829	0	None	-	0	Human	8.5	pKi	=	8.5	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	433	6	3	9	1.5	COC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3970041	151829	0	None	-	0	Human	8.5	pKi	=	8.5	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	433	6	3	9	1.5	COC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	11957541	1430	38	None	1	4	Human	8.5	pKi	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	1229	1430	38	None	1	4	Human	8.5	pKi	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	147	1430	38	None	1	4	Human	8.5	pKi	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	170617	1430	38	None	1	4	Human	8.5	pKi	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	CHEMBL6616	1430	38	None	1	4	Human	8.5	pKi	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	10609802	106708	2	None	-	1	Human	6.5	pKi	=	6.5	Functional	Agonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligandAgonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligand	ChEMBL	235	3	1	4	1.1	COc1c2c(c(CCN)c3c1OCC3)CCO2	10.1021/jm970219x
	CHEMBL316527	106708	2	None	-	1	Human	6.5	pKi	=	6.5	Functional	Agonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligandAgonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligand	ChEMBL	235	3	1	4	1.1	COc1c2c(c(CCN)c3c1OCC3)CCO2	10.1021/jm970219x
	1530	2151	44	None	-3	21	Human	7.5	pKi	=	7.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm100856p
	3827	2151	44	None	-3	21	Human	7.5	pKi	=	7.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm100856p
	7206	2151	44	None	-3	21	Human	7.5	pKi	=	7.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm100856p
	CHEMBL534	2151	44	None	-3	21	Human	7.5	pKi	=	7.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm100856p
	DB00920	2151	44	None	-3	21	Human	7.5	pKi	=	7.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm100856p
	10440	2642	15	None	-	3	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assayAntagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	139030523	2642	15	None	-	3	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assayAntagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	CHEMBL4449712	2642	15	None	-	3	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assayAntagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	10751567	4471	2	None	-	1	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine radioligandAntagonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine radioligand	ChEMBL	223	4	1	4	1.1	COc1cc(CCN)c2c(c1OC)OCC2	10.1021/jm970219x
	CHEMBL102347	4471	2	None	-	1	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine radioligandAntagonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine radioligand	ChEMBL	223	4	1	4	1.1	COc1cc(CCN)c2c(c1OC)OCC2	10.1021/jm970219x
	49864841	15555	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	266	1	1	4	1.6	C1=C(N2CCNCC2)c2nccn2Cc2ccccc21	10.1016/j.bmcl.2010.07.029
	CHEMBL1222552	15555	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	266	1	1	4	1.6	C1=C(N2CCNCC2)c2nccn2Cc2ccccc21	10.1016/j.bmcl.2010.07.029
	49834053	15601	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	384	4	1	5	2.6	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3cc(F)nc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	CHEMBL1222763	15601	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	384	4	1	5	2.6	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3cc(F)nc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	49836634	18479	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	361	3	1	2	4.0	O=C(O)CC1CN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1277034	18479	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	361	3	1	2	4.0	O=C(O)CC1CN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	49833882	15584	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	392	3	1	5	3.0	O=C(O)C1CCC(N2CCN(C3=Cc4ccccc4Cn4ccnc43)CC2)CC1	10.1016/j.bmcl.2010.07.029
	CHEMBL1222692	15584	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	392	3	1	5	3.0	O=C(O)C1CCC(N2CCN(C3=Cc4ccccc4Cn4ccnc43)CC2)CC1	10.1016/j.bmcl.2010.07.029
	25110703	189128	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at 5HT2B receptorAntagonist activity at 5HT2B receptor	ChEMBL	360	2	1	4	3.2	O=S(=O)(c1ccccc1)n1cc(Cl)c2cc3c(cc21)CCNCC3	10.1016/j.bmcl.2008.08.010
	CHEMBL515624	189128	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at 5HT2B receptorAntagonist activity at 5HT2B receptor	ChEMBL	360	2	1	4	3.2	O=S(=O)(c1ccccc1)n1cc(Cl)c2cc3c(cc21)CCNCC3	10.1016/j.bmcl.2008.08.010
	49836528	18471	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	373	2	1	2	4.0	O=C(O)[C@]12C[C@H]1CN(C1CC[C@]3(Cc4ccccc4Cc4ccccc43)C1)C2	10.1021/jm100856p
	CHEMBL1276947	18471	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	373	2	1	2	4.0	O=C(O)[C@]12C[C@H]1CN(C1CC[C@]3(Cc4ccccc4Cc4ccccc43)C1)C2	10.1021/jm100856p
	134152052	152549	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	432	6	4	8	1.1	CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3976121	152549	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	432	6	4	8	1.1	CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	44156628	6636	3	None	-	0	Human	6.3	pKi	=	6.3	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometry	ChEMBL	328	3	1	6	2.1	CNc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CCC3	10.1021/jm100350r
	CHEMBL1083654	6636	3	None	-	0	Human	6.3	pKi	=	6.3	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometry	ChEMBL	328	3	1	6	2.1	CNc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CCC3	10.1021/jm100350r
	10751567	4471	2	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligandAgonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligand	ChEMBL	223	4	1	4	1.1	COc1cc(CCN)c2c(c1OC)OCC2	10.1021/jm970219x
	CHEMBL102347	4471	2	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligandAgonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligand	ChEMBL	223	4	1	4	1.1	COc1cc(CCN)c2c(c1OC)OCC2	10.1021/jm970219x
	38240	107513	18	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligandAgonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligand	ChEMBL	225	6	1	4	1.6	CCOc1c(OC)cc(CCN)cc1OC	10.1021/jm970219x
	CHEMBL319415	107513	18	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligandAgonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligand	ChEMBL	225	6	1	4	1.6	CCOc1c(OC)cc(CCN)cc1OC	10.1021/jm970219x
	49833884	15586	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	380	4	1	5	2.8	Cc1cn2c(n1)C(N1CCN(CC(C)(C)C(=O)O)CC1)=Cc1ccccc1C2	10.1016/j.bmcl.2010.07.029
	CHEMBL1222694	15586	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	380	4	1	5	2.8	Cc1cn2c(n1)C(N1CCN(CC(C)(C)C(=O)O)CC1)=Cc1ccccc1C2	10.1016/j.bmcl.2010.07.029
	49864886	15569	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	366	4	1	5	2.6	CC1CN(C2=Cc3ccccc3Cn3ccnc32)CC(C)N1CCC(=O)O	10.1016/j.bmcl.2010.07.029
	CHEMBL1222624	15569	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	366	4	1	5	2.6	CC1CN(C2=Cc3ccccc3Cn3ccnc32)CC(C)N1CCC(=O)O	10.1016/j.bmcl.2010.07.029
	155558626	174189	0	None	-	1	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assayAntagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assay	ChEMBL	355	6	3	6	2.9	Nc1nc(NCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
	CHEMBL4561016	174189	0	None	-	1	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assayAntagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assay	ChEMBL	355	6	3	6	2.9	Nc1nc(NCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
	49836633	18472	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	347	2	1	2	3.6	O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1276948	18472	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	347	2	1	2	3.6	O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	25184832	18508	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	349	2	1	3	3.8	O=C(O)C1CN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1277312	18508	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	349	2	1	3	3.8	O=C(O)C1CN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)C1	10.1021/jm100856p
	4076	96585	23	None	-	1	Human	6.1	pKi	=	6.1	Functional	Agonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligandAgonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligand	ChEMBL	211	5	1	4	1.2	COc1cc(CCN)cc(OC)c1OC	10.1021/jm970219x
	CHEMBL26687	96585	23	None	-	1	Human	6.1	pKi	=	6.1	Functional	Agonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligandAgonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligand	ChEMBL	211	5	1	4	1.2	COc1cc(CCN)cc(OC)c1OC	10.1021/jm970219x
	2995	202700	49	None	-2	6	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL1696	202700	49	None	-2	6	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL72	202700	49	None	-2	6	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	1225	1443	24	None	-3	11	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	3958	1443	24	None	-3	11	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	667477	1443	24	None	-3	11	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	CHEMBL860	1443	24	None	-3	11	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	DB01142	1443	24	None	-3	11	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	2105	3005	34	None	-5	19	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	47811	3005	34	None	-5	19	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	48	3005	34	None	-5	19	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	CHEMBL531	3005	34	None	-5	19	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	DB01186	3005	34	None	-5	19	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	439280	119514	104	None	-3	7	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	Drug Central	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	None
	6971044	119514	104	None	-3	7	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	Drug Central	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	None
	CHEMBL350221	119514	104	None	-3	7	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	Drug Central	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	None
	11658860	2312	47	None	-63	4	Human	6.0	pEC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
	2941	2312	47	None	-63	4	Human	6.0	pEC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
	4374	2312	47	None	-63	4	Human	6.0	pEC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
	CHEMBL360328	2312	47	None	-63	4	Human	6.0	pEC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
	DB04871	2312	47	None	-63	4	Human	6.0	pEC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
	30699	215969	0	None	-1	14	Human	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	423	7	2	8	0.5	CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)CSC1=CC=NC=C1)C2=O)C(O)=O	None
	5215	168401	100	None	1	3	Human	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	250	3	2	5	0.9	Nc1ccc(S(=O)(=O)Nc2ncccn2)cc1	None
	CHEMBL439	168401	100	None	1	3	Human	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	250	3	2	5	0.9	Nc1ccc(S(=O)(=O)Nc2ncccn2)cc1	None
	4421	215989	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	232	2	1	4	1.4	CCN1C=C(C(O)=O)C(=O)C2=CC=C(C)N=C12	None
	14052	215979	0	None	1	3	Human	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	204	9	4	4	-0.3	CC[C@@H](CO)NCCN[C@@H](CC)CO	None
	33613	215959	0	None	-1	3	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	365	4	4	6	0.0	CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)C3=CC=C(O)C=C3)C(=O)N2[C@H]1C(O)=O	None
	2337	3205	72	None	-5	22	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3205	72	None	-5	22	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3205	72	None	-5	22	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3205	72	None	-5	22	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3205	72	None	-5	22	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None

Get vendors

Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	10198431	73557	0	None	-7	3	Human	9.0	pEC50	=	9.0	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL201930	73557	0	None	-7	3	Human	9.0	pEC50	=	9.0	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	5	139	66	None	-13	54	Human	8.8	pEC50	=	8.8	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2005.10.029
	5202	139	66	None	-13	54	Human	8.8	pEC50	=	8.8	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2005.10.029
	CHEMBL39	139	66	None	-13	54	Human	8.8	pEC50	=	8.8	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2005.10.029
	DB08839	139	66	None	-13	54	Human	8.8	pEC50	=	8.8	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2005.10.029
	44407335	72747	0	None	-7	3	Human	6.9	pEC50	=	6.9	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	321	5	1	3	4.7	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCC1CCCCC1	10.1016/j.bmcl.2005.10.029
	CHEMBL201117	72747	0	None	-7	3	Human	6.9	pEC50	=	6.9	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	321	5	1	3	4.7	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCC1CCCCC1	10.1016/j.bmcl.2005.10.029
	44407440	138776	0	None	-4	3	Human	6.9	pEC50	=	6.9	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	329	5	1	3	4.7	Cc1ccccc1CN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL379223	138776	0	None	-4	3	Human	6.9	pEC50	=	6.9	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	329	5	1	3	4.7	Cc1ccccc1CN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	18715554	74075	0	None	-10	3	Human	6.8	pEC50	=	6.8	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3cnccc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL202656	74075	0	None	-10	3	Human	6.8	pEC50	=	6.8	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3cnccc3c21	10.1016/j.bmcl.2005.10.029
	18715564	73033	0	None	-7	3	Human	8.7	pEC50	=	8.7	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	259	2	1	3	3.2	C[C@H](N)Cn1ccc2cc(Cl)c3ncccc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL201454	73033	0	None	-7	3	Human	8.7	pEC50	=	8.7	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	259	2	1	3	3.2	C[C@H](N)Cn1ccc2cc(Cl)c3ncccc3c21	10.1016/j.bmcl.2005.10.029
	18715555	74026	0	None	-8	3	Human	7.7	pEC50	=	7.7	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	359	5	1	5	4.1	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2005.10.029
	CHEMBL202458	74026	0	None	-8	3	Human	7.7	pEC50	=	7.7	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	359	5	1	5	4.1	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2005.10.029
	135398737	944	89	None	-2	91	Human	7.7	pEC50	=	7.7	Binding	Inverse agonist activity at human 5HT2B receptor by R-SAT assayInverse agonist activity at human 5HT2B receptor by R-SAT assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	38	944	89	None	-2	91	Human	7.7	pEC50	=	7.7	Binding	Inverse agonist activity at human 5HT2B receptor by R-SAT assayInverse agonist activity at human 5HT2B receptor by R-SAT assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	722	944	89	None	-2	91	Human	7.7	pEC50	=	7.7	Binding	Inverse agonist activity at human 5HT2B receptor by R-SAT assayInverse agonist activity at human 5HT2B receptor by R-SAT assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	CHEMBL42	944	89	None	-2	91	Human	7.7	pEC50	=	7.7	Binding	Inverse agonist activity at human 5HT2B receptor by R-SAT assayInverse agonist activity at human 5HT2B receptor by R-SAT assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	DB00363	944	89	None	-2	91	Human	7.7	pEC50	=	7.7	Binding	Inverse agonist activity at human 5HT2B receptor by R-SAT assayInverse agonist activity at human 5HT2B receptor by R-SAT assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	44407398	74069	0	None	-8	3	Human	7.6	pEC50	=	7.6	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	365	5	1	3	5.5	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccc2ccccc2c1	10.1016/j.bmcl.2005.10.029
	CHEMBL202616	74069	0	None	-8	3	Human	7.6	pEC50	=	7.6	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	365	5	1	3	5.5	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccc2ccccc2c1	10.1016/j.bmcl.2005.10.029
	5	139	66	None	-29	54	Rat	8.4	pEC50	=	8.4	Binding	Agonist activity at 5HT2b receptor in Wistar rat fundus measured for 90 secsAgonist activity at 5HT2b receptor in Wistar rat fundus measured for 90 secs	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2015.08.051
	5202	139	66	None	-29	54	Rat	8.4	pEC50	=	8.4	Binding	Agonist activity at 5HT2b receptor in Wistar rat fundus measured for 90 secsAgonist activity at 5HT2b receptor in Wistar rat fundus measured for 90 secs	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2015.08.051
	CHEMBL39	139	66	None	-29	54	Rat	8.4	pEC50	=	8.4	Binding	Agonist activity at 5HT2b receptor in Wistar rat fundus measured for 90 secsAgonist activity at 5HT2b receptor in Wistar rat fundus measured for 90 secs	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2015.08.051
	DB08839	139	66	None	-29	54	Rat	8.4	pEC50	=	8.4	Binding	Agonist activity at 5HT2b receptor in Wistar rat fundus measured for 90 secsAgonist activity at 5HT2b receptor in Wistar rat fundus measured for 90 secs	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2015.08.051
	166	3307	12	None	1	3	Human	8.4	pEC50	=	8.4	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2005.10.029
	3045227	3307	12	None	1	3	Human	8.4	pEC50	=	8.4	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2005.10.029
	CHEMBL76781	3307	12	None	1	3	Human	8.4	pEC50	=	8.4	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2005.10.029
	44407453	74054	0	None	-9	3	Human	7.4	pEC50	=	7.4	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	349	5	1	3	5.0	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccccc1Cl	10.1016/j.bmcl.2005.10.029
	CHEMBL202538	74054	0	None	-9	3	Human	7.4	pEC50	=	7.4	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	349	5	1	3	5.0	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccccc1Cl	10.1016/j.bmcl.2005.10.029
	18715561	72697	0	None	-4	3	Human	7.4	pEC50	=	7.4	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3cccnc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL201062	72697	0	None	-4	3	Human	7.4	pEC50	=	7.4	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3cccnc3c21	10.1016/j.bmcl.2005.10.029
	44407327	140716	0	None	-5	3	Human	6.3	pEC50	=	6.3	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	345	6	1	4	4.4	COc1ccccc1CN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL383042	140716	0	None	-5	3	Human	6.3	pEC50	=	6.3	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	345	6	1	4	4.4	COc1ccccc1CN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	18715558	73534	0	None	-5	3	Human	7.2	pEC50	=	7.2	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3ccncc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL201897	73534	0	None	-5	3	Human	7.2	pEC50	=	7.2	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3ccncc3c21	10.1016/j.bmcl.2005.10.029
	9901086	187048	28	None	-	2	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at 5HT2B receptor (unknown origin) relative to controlAgonist activity at 5HT2B receptor (unknown origin) relative to control	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm5019274
	CHEMBL494947	187048	28	None	-	2	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at 5HT2B receptor (unknown origin) relative to controlAgonist activity at 5HT2B receptor (unknown origin) relative to control	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm5019274
	44407337	73856	0	None	-5	3	Human	7.0	pEC50	=	7.0	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	265	5	1	3	3.4	C=CCN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL202324	73856	0	None	-5	3	Human	7.0	pEC50	=	7.0	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	265	5	1	3	3.4	C=CCN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	44407460	139820	0	None	-6	3	Human	7.0	pEC50	=	7.0	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	315	5	1	3	4.4	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccccc1	10.1016/j.bmcl.2005.10.029
	CHEMBL380763	139820	0	None	-6	3	Human	7.0	pEC50	=	7.0	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	315	5	1	3	4.4	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccccc1	10.1016/j.bmcl.2005.10.029
	CHEMBL5081637	212985	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Modulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assayModulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assay	ChEMBL		None	None	None		CN(CCc1cn(C)c2cccc(O)c12)CC1CC1	10.1021/acsmedchemlett.1c00578
	133	2460	48	None	-2	42	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	1723	2460	48	None	-2	42	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	28693	2460	48	None	-2	42	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	CHEMBL19215	2460	48	None	-2	42	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	DB13520	2460	48	None	-2	42	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	134	2478	19	None	-2	67	Human	9.3	pIC50	=	9.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	1775	2478	19	None	-2	67	Human	9.3	pIC50	=	9.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	9681	2478	19	None	-2	67	Human	9.3	pIC50	=	9.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	CHEMBL1065	2478	19	None	-2	67	Human	9.3	pIC50	=	9.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	DB00247	2478	19	None	-2	67	Human	9.3	pIC50	=	9.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	11291	3169	23	None	-	4	Human	9.0	pIC50	=	9.0	Binding	Modulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assayModulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acsmedchemlett.1c00578
	4980	3169	23	None	-	4	Human	9.0	pIC50	=	9.0	Binding	Modulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assayModulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acsmedchemlett.1c00578
	CHEMBL65547	3169	23	None	-	4	Human	9.0	pIC50	=	9.0	Binding	Modulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assayModulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acsmedchemlett.1c00578
	150	2473	18	None	1	15	Human	8.8	pIC50	=	8.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	1764	2473	18	None	1	15	Human	8.8	pIC50	=	8.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	8226	2473	18	None	1	15	Human	8.8	pIC50	=	8.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	CHEMBL1201356	2473	18	None	1	15	Human	8.8	pIC50	=	8.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	DB00353	2473	18	None	1	15	Human	8.8	pIC50	=	8.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	191	399	92	None	-5	28	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	201	399	92	None	-5	28	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	2170	399	92	None	-5	28	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	CHEMBL1113	399	92	None	-5	28	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	DB00543	399	92	None	-5	28	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	2099	9217	49	None	-	1	Human	7.0	pIC50	=	7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	nan
	CHEMBL1110	9217	49	None	-	1	Human	7.0	pIC50	=	7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	nan
	11518143	88637	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of 5-HT2B (unknown origin)Inhibition of 5-HT2B (unknown origin)	ChEMBL	454	12	1	5	4.0	COCCCOc1cc(C(=O)N(C[C@@H]2CNC[C@H]2Cc2ccccc2)C(C)C)ccc1OC	10.1021/jm3017078
	CHEMBL2322611	88637	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of 5-HT2B (unknown origin)Inhibition of 5-HT2B (unknown origin)	ChEMBL	454	12	1	5	4.0	COCCCOc1cc(C(=O)N(C[C@@H]2CNC[C@H]2Cc2ccccc2)C(C)C)ccc1OC	10.1021/jm3017078
	CHEMBL2365004	88637	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of 5-HT2B (unknown origin)Inhibition of 5-HT2B (unknown origin)	ChEMBL	454	12	1	5	4.0	COCCCOc1cc(C(=O)N(C[C@@H]2CNC[C@H]2Cc2ccccc2)C(C)C)ccc1OC	10.1021/jm3017078
	2274	3124	53	None	-10	32	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	4917	3124	53	None	-10	32	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	7279	3124	53	None	-10	32	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	CHEMBL728	3124	53	None	-10	32	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	DB00433	3124	53	None	-10	32	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	25060119	103837	0	None	-9332	7	Human	6.0	pIC50	=	6.0	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	493	7	1	5	6.1	COc1ccc(CNC(=O)c2cc(-c3cc(Cl)cc(Cl)c3)cnc2-c2cccnc2)cc1OC	10.1016/j.bmcl.2013.10.045
	CHEMBL3099899	103837	0	None	-9332	7	Human	6.0	pIC50	=	6.0	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	493	7	1	5	6.1	COc1ccc(CNC(=O)c2cc(-c3cc(Cl)cc(Cl)c3)cnc2-c2cccnc2)cc1OC	10.1016/j.bmcl.2013.10.045
	3033538	1292	36	None	-12	9	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
	7155	1292	36	None	-12	9	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
	781	1292	36	None	-12	9	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
	CHEMBL1201216	1292	36	None	-12	9	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
	DB00298	1292	36	None	-12	9	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
	213	3792	50	None	-3	43	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
	2717	3792	50	None	-3	43	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
	5533	3792	50	None	-3	43	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
	CHEMBL621	3792	50	None	-3	43	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
	DB00656	3792	50	None	-3	43	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
	12488	1627	51	None	-11	23	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
	941361	1627	51	None	-11	23	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
	CHEMBL30008	1627	51	None	-11	23	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
	DB04841	1627	51	None	-11	23	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
	135398737	944	89	None	-2	91	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	38	944	89	None	-2	91	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	722	944	89	None	-2	91	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	CHEMBL42	944	89	None	-2	91	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	DB00363	944	89	None	-2	91	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	73453	29403	22	None	-9	17	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
	CHEMBL1385840	29403	22	None	-9	17	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
	25070577	111175	3	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	304	3	2	4	2.3	CNc1nc(C(F)(F)c2ccccc2)nc2c1CCNCC2	10.1021/jm5003292
	CHEMBL3286557	111175	3	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	304	3	2	4	2.3	CNc1nc(C(F)(F)c2ccccc2)nc2c1CCNCC2	10.1021/jm5003292
	240	931	39	None	-6	25	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
	2769	931	39	None	-6	25	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
	44279790	931	39	None	-6	25	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
	660	931	39	None	-6	25	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
	CHEMBL1729	931	39	None	-6	25	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
	CHEMBL560739	931	39	None	-6	25	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
	DB00604	931	39	None	-6	25	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
	146159245	187866	27	None	-	1	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	nan
	451415	187866	27	None	-	1	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	nan
	86289437	187866	27	None	-	1	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	nan
	CHEMBL502620	187866	27	None	-	1	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	nan
	1224	1404	79	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	3100	1404	79	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	8980	1404	79	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	916	1404	79	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	CHEMBL657	1404	79	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	DB01075	1404	79	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	4178	194130	58	None	-	1	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	179	3	1	2	2.0	Cc1cccc(C)c1OCC(C)N	nan
	CHEMBL558	194130	58	None	-	1	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	179	3	1	2	2.0	Cc1cccc(C)c1OCC(C)N	nan
	44190762	176306	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of radioligand from 5HT2B receptorDisplacement of radioligand from 5HT2B receptor	ChEMBL	531	8	1	5	6.6	Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1	10.1016/j.bmcl.2008.07.103
	CHEMBL461571	176306	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of radioligand from 5HT2B receptorDisplacement of radioligand from 5HT2B receptor	ChEMBL	531	8	1	5	6.6	Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1	10.1016/j.bmcl.2008.07.103
	222757	98917	70	None	-1	3	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	376	2	1	3	5.1	C[C@]12CC[C@@H]3c4ccc(OC(=O)c5ccccc5)cc4CC[C@H]3[C@@H]1CC[C@@H]2O	nan
	CHEMBL282575	98917	70	None	-1	3	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	376	2	1	3	5.1	C[C@]12CC[C@@H]3c4ccc(OC(=O)c5ccccc5)cc4CC[C@H]3[C@@H]1CC[C@@H]2O	nan
	2812	4711	96	None	-40	34	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
	CHEMBL104	4711	96	None	-40	34	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
	2247	502	77	None	-4	41	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	249	502	77	None	-4	41	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	2603	502	77	None	-4	41	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	CHEMBL296419	502	77	None	-4	41	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	DB00637	502	77	None	-4	41	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	23027035	196870	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	367	5	2	5	3.3	Cc1ccc(C(=O)N[C@H]2CC[C@@H](Nc3ncc(C)c(N(C)C)n3)CC2)cc1	10.1016/j.bmcl.2009.09.003
	CHEMBL578170	196870	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	367	5	2	5	3.3	Cc1ccc(C(=O)N[C@H]2CC[C@@H](Nc3ncc(C)c(N(C)C)n3)CC2)cc1	10.1016/j.bmcl.2009.09.003
	54764239	68524	0	None	-	1	Human	4.9	pIC50	=	4.9	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	272	2	1	3	2.7	CC/C=C1\C[C@H]2CNc3c(OC)cccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
	CHEMBL1922537	68524	0	None	-	1	Human	4.9	pIC50	=	4.9	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	272	2	1	3	2.7	CC/C=C1\C[C@H]2CNc3c(OC)cccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
	2726	906	64	None	-19	72	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	621	906	64	None	-19	72	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	83	906	64	None	-19	72	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	CHEMBL71	906	64	None	-19	72	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	DB00477	906	64	None	-19	72	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	76072441	153413	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	391	7	0	4	3.4	C=CCN1CC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)OC1=O	nan
	CHEMBL3983539	153413	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	391	7	0	4	3.4	C=CCN1CC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)OC1=O	nan
	100	3745	52	None	-11	55	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	2637	3745	52	None	-11	55	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	5452	3745	52	None	-11	55	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	CHEMBL479	3745	52	None	-11	55	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	DB00679	3745	52	None	-11	55	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	134551	355	25	None	-6	21	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
	271	355	25	None	-6	21	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
	885	355	25	None	-6	21	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
	CHEMBL1403281	355	25	None	-6	21	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
	23027211	195574	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	421	5	2	5	4.3	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)c(Cl)c3)CC2)n1	10.1016/j.bmcl.2009.09.003
	CHEMBL568400	195574	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	421	5	2	5	4.3	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)c(Cl)c3)CC2)n1	10.1016/j.bmcl.2009.09.003
	100951644	169067	11	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	411	7	2	9	2.3	CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(c3cccnn3)C2)s1)c1ccccc1	10.1021/acs.jmedchem.9b00260
	CHEMBL4437106	169067	11	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	411	7	2	9	2.3	CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(c3cccnn3)C2)s1)c1ccccc1	10.1021/acs.jmedchem.9b00260
	3042	1386	31	None	-39	15	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	355	1386	31	None	-39	15	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	868	1386	31	None	-39	15	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	CHEMBL1123	1386	31	None	-39	15	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	DB00804	1386	31	None	-39	15	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	5591	156989	84	None	1	2	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	nan
	CHEMBL408	156989	84	None	1	2	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	nan
	3168	9172	84	None	-107	21	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
	CHEMBL1108	9172	84	None	-107	21	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
	127048333	140149	0	None	38	3	Human	6.9	pIC50	=	6.9	Binding	Antagonist activity at human 5-HT2B receptor by PDSP assayAntagonist activity at human 5-HT2B receptor by PDSP assay	ChEMBL	465	12	0	5	5.3	COc1ccc(CCN(CCCc2ccccc2F)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3815112	140149	0	None	38	3	Human	6.9	pIC50	=	6.9	Binding	Antagonist activity at human 5-HT2B receptor by PDSP assayAntagonist activity at human 5-HT2B receptor by PDSP assay	ChEMBL	465	12	0	5	5.3	COc1ccc(CCN(CCCc2ccccc2F)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	4543	169982	36	None	-3	29	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2ccccc21	nan
	CHEMBL1201156	169982	36	None	-3	29	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2ccccc21	nan
	CHEMBL445	169982	36	None	-3	29	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2ccccc21	nan
	1548953	205945	24	None	-4	17	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
	CHEMBL954	205945	24	None	-4	17	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
	5870	31445	85	None	-	1	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	270	0	1	2	3.8	C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CCC2=O	nan
	CHEMBL1405	31445	85	None	-	1	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	270	0	1	2	3.8	C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CCC2=O	nan
	6319	23272	90	None	-	1	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	4	2	2	5.2	c1ccc(Nc2ccc(Nc3ccccc3)cc2)cc1	nan
	CHEMBL1333512	23272	90	None	-	1	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	4	2	2	5.2	c1ccc(Nc2ccc(Nc3ccccc3)cc2)cc1	nan
	1305	508	10	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2009.09.003
	9934033	508	10	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2009.09.003
	CHEMBL182150	508	10	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2009.09.003
	121318543	176993	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5-HT2B (unknown origin)Inhibition of 5-HT2B (unknown origin)	ChEMBL	560	6	0	6	4.7	COc1c(S(C)(=O)=O)ccc(O[C@@H](C)C(F)(F)F)c1C(=O)N1CC(c2ncc(C(F)(F)F)cc2Cl)C1	10.1016/j.bmcl.2020.127214
	CHEMBL4640428	176993	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5-HT2B (unknown origin)Inhibition of 5-HT2B (unknown origin)	ChEMBL	560	6	0	6	4.7	COc1c(S(C)(=O)=O)ccc(O[C@@H](C)C(F)(F)F)c1C(=O)N1CC(c2ncc(C(F)(F)F)cc2Cl)C1	10.1016/j.bmcl.2020.127214
	16665072	98086	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5HT2BInhibition of 5HT2B	ChEMBL	449	8	1	6	3.6	CN(C)CCN(C)c1nc2ccc(NC(=O)COc3ccc(C(F)(F)F)cc3)cc2n1C	10.1016/j.bmcl.2006.11.092
	CHEMBL276393	98086	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5HT2BInhibition of 5HT2B	ChEMBL	449	8	1	6	3.6	CN(C)CCN(C)c1nc2ccc(NC(=O)COc3ccc(C(F)(F)F)cc3)cc2n1C	10.1016/j.bmcl.2006.11.092
	155558726	174236	0	None	-19	4	Human	4.8	pIC50	=	4.8	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	835	11	0	13	6.7	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CC[C@H]3O[C@H](Cn4cc(nn4)COC[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12)[C@@H]1OC(C)(C)O[C@@H]1[C@H]3OCCC(C)C	10.1016/j.ejmech.2019.04.064
	CHEMBL4562303	174236	0	None	-19	4	Human	4.8	pIC50	=	4.8	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	835	11	0	13	6.7	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CC[C@H]3O[C@H](Cn4cc(nn4)COC[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12)[C@@H]1OC(C)(C)O[C@@H]1[C@H]3OCCC(C)C	10.1016/j.ejmech.2019.04.064
	667590	67452	12	None	-	1	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	3	0	1	4.4	O=C(c1ccccc1Cl)N1CCC(Cc2ccccc2)CC1	nan
	CHEMBL1909048	67452	12	None	-	1	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	3	0	1	4.4	O=C(c1ccccc1Cl)N1CCC(Cc2ccccc2)CC1	nan
	44112	120777	41	None	-11	7	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	nan
	CHEMBL357995	120777	41	None	-11	7	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	nan
	17683252	67454	3	None	-	1	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	347	3	0	1	4.8	O=C(c1ccccc1C(F)(F)F)N1CCC(Cc2ccccc2)CC1	nan
	CHEMBL1909051	67454	3	None	-	1	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	347	3	0	1	4.8	O=C(c1ccccc1C(F)(F)F)N1CCC(Cc2ccccc2)CC1	nan
	155565189	174992	0	None	-6	4	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	634	7	0	9	6.2	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CCCCCCOCc3cn(nn3)C[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12	10.1016/j.ejmech.2019.04.064
	CHEMBL4579120	174992	0	None	-6	4	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	634	7	0	9	6.2	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CCCCCCOCc3cn(nn3)C[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12	10.1016/j.ejmech.2019.04.064
	3525815	73798	3	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5HT2BInhibition of 5HT2B	ChEMBL	271	2	0	3	4.1	c1ccc(-n2cc(-c3ccnc4ccccc34)cn2)cc1	10.1016/j.bmcl.2012.03.032
	CHEMBL2022867	73798	3	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5HT2BInhibition of 5HT2B	ChEMBL	271	2	0	3	4.1	c1ccc(-n2cc(-c3ccnc4ccccc34)cn2)cc1	10.1016/j.bmcl.2012.03.032
	2520	202310	65	None	-4	11	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
	CHEMBL1280	202310	65	None	-4	11	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
	CHEMBL6966	202310	65	None	-4	11	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
	23027245	195452	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	387	5	2	5	3.7	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)cc3)CC2)n1	10.1016/j.bmcl.2009.09.003
	CHEMBL567791	195452	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	387	5	2	5	3.7	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)cc3)CC2)n1	10.1016/j.bmcl.2009.09.003
	10660	14298	55	None	-29	12	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
	CHEMBL1200406	14298	55	None	-29	12	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
	2333	141803	91	None	1	2	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	nan
	CHEMBL388590	141803	91	None	1	2	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	nan
	2771	193347	67	None	1	26	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	nan
	CHEMBL1200781	193347	67	None	1	26	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	nan
	CHEMBL549	193347	67	None	1	26	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	nan
	104903	56050	14	None	-4	6	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	nan
	CHEMBL1630578	56050	14	None	-4	6	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	nan
	2723	153512	104	None	-	1	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	156	0	1	1	2.7	Cc1cc(O)cc(C)c1Cl	nan
	CHEMBL398440	153512	104	None	-	1	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	156	0	1	1	2.7	Cc1cc(O)cc(C)c1Cl	nan
	1379258	67453	13	None	-	1	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	293	3	0	1	4.1	Cc1ccccc1C(=O)N1CCC(Cc2ccccc2)CC1	nan
	CHEMBL1909050	67453	13	None	-	1	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	293	3	0	1	4.1	Cc1ccccc1C(=O)N1CCC(Cc2ccccc2)CC1	nan
	76072442	145855	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	407	5	0	4	4.0	CC(C)(C)N1CC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)OC1=O	nan
	CHEMBL3921628	145855	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	407	5	0	4	4.0	CC(C)(C)N1CC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)OC1=O	nan
	11277147	105860	0	None	9	2	Human	7.7	pIC50	=	7.7	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysisAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3092759	105860	0	None	9	2	Human	7.7	pIC50	=	7.7	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysisAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3139188	105860	0	None	9	2	Human	7.7	pIC50	=	7.7	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysisAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	76072471	153003	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	405	6	0	4	3.8	O=C1OC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)CN1C1CCC1	nan
	CHEMBL3980023	153003	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	405	6	0	4	3.8	O=C1OC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)CN1C1CCC1	nan
	11452268	81161	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of 5HT2BInhibition of 5HT2B	ChEMBL	396	5	1	5	4.2	Cc1nc(N2CCCC2)nc2ccc(NC(=O)COc3ccc(Cl)cc3)cc12	10.1016/j.bmcl.2006.11.092
	CHEMBL216228	81161	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of 5HT2BInhibition of 5HT2B	ChEMBL	396	5	1	5	4.2	Cc1nc(N2CCCC2)nc2ccc(NC(=O)COc3ccc(Cl)cc3)cc12	10.1016/j.bmcl.2006.11.092
	11957541	1430	38	None	-1	15	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cellsDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.03.006
	1229	1430	38	None	-1	15	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cellsDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.03.006
	147	1430	38	None	-1	15	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cellsDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.03.006
	170617	1430	38	None	-1	15	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cellsDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.03.006
	CHEMBL6616	1430	38	None	-1	15	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cellsDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.03.006
	11957541	1430	38	None	-1	15	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.11.014
	1229	1430	38	None	-1	15	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.11.014
	147	1430	38	None	-1	15	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.11.014
	170617	1430	38	None	-1	15	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.11.014
	CHEMBL6616	1430	38	None	-1	15	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.11.014
	9881053	119740	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Ability to displace [3H]5-HT from 5-hydroxytryptamine 2B receptorAbility to displace [3H]5-HT from 5-hydroxytryptamine 2B receptor	ChEMBL	339	5	1	4	4.1	CCCN1CCC(COc2nc3ccccc3c3c2CCCN3)CC1	10.1021/jm020954v
	CHEMBL35226	119740	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Ability to displace [3H]5-HT from 5-hydroxytryptamine 2B receptorAbility to displace [3H]5-HT from 5-hydroxytryptamine 2B receptor	ChEMBL	339	5	1	4	4.1	CCCN1CCC(COc2nc3ccccc3c3c2CCCN3)CC1	10.1021/jm020954v
	1201549	590	22	None	-26	20	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	333	590	22	None	-26	20	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	7601	590	22	None	-26	20	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	CHEMBL1201203	590	22	None	-26	20	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	CHEMBL438151	590	22	None	-26	20	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	DB00245	590	22	None	-26	20	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	5510	204137	97	None	-	1	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	2	0	2	4.9	Cc1cccc(N(C)C(=S)Oc2ccc3ccccc3c2)c1	nan
	CHEMBL83668	204137	97	None	-	1	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	2	0	2	4.9	Cc1cccc(N(C)C(=S)Oc2ccc3ccccc3c2)c1	nan
	44393396	126775	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibitory activity against human 5-HT2B receptorInhibitory activity against human 5-HT2B receptor	ChEMBL	458	5	1	5	4.6	Cc1cc(N2CCN(C)CC2)nc2ccc(NC(=O)COc3cccc(Cl)c3Cl)cc12	10.1016/j.bmcl.2004.05.051
	CHEMBL365882	126775	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibitory activity against human 5-HT2B receptorInhibitory activity against human 5-HT2B receptor	ChEMBL	458	5	1	5	4.6	Cc1cc(N2CCN(C)CC2)nc2ccc(NC(=O)COc3cccc(Cl)c3Cl)cc12	10.1016/j.bmcl.2004.05.051
	4122	205891	102	None	-3	3	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	301	3	2	5	3.0	COC(=O)Nc1nc2ccc(C(=O)c3cccs3)cc2[nH]1	nan
	CHEMBL9514	205891	102	None	-3	3	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	301	3	2	5	3.0	COC(=O)Nc1nc2ccc(C(=O)c3cccs3)cc2[nH]1	nan
	1353	1880	85	None	-295	85	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	3559	1880	85	None	-295	85	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	86	1880	85	None	-295	85	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	CHEMBL54	1880	85	None	-295	85	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	DB00502	1880	85	None	-295	85	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	1016	3690	75	None	-17	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	2561	3690	75	None	-17	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	2733526	3690	75	None	-17	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	5384	3690	75	None	-17	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	CHEMBL83	3690	75	None	-17	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	DB00675	3690	75	None	-17	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	CHEMBL1909069	207332	0	None	-1	3	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL		None	None	None		None	nan
	1343	1858	55	None	-14	9	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
	3519	1858	55	None	-14	9	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
	522	1858	55	None	-14	9	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
	CHEMBL862	1858	55	None	-14	9	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
	DB01018	1858	55	None	-14	9	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
	2337	3205	72	None	-15	62	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	50	3205	72	None	-15	62	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	5002	3205	72	None	-15	62	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	CHEMBL716	3205	72	None	-15	62	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	DB01224	3205	72	None	-15	62	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	122196341	123754	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Antagonist activity at human 5HT2bAntagonist activity at human 5HT2b	ChEMBL	422	5	1	3	6.0	O=c1ccc(-c2ccc(OCc3ccc4ccccc4n3)cc2)c(-c2ccc(F)cc2)[nH]1	10.1021/acs.jmedchem.5b01240
	CHEMBL3634745	123754	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Antagonist activity at human 5HT2bAntagonist activity at human 5HT2b	ChEMBL	422	5	1	3	6.0	O=c1ccc(-c2ccc(OCc3ccc4ccccc4n3)cc2)c(-c2ccc(F)cc2)[nH]1	10.1021/acs.jmedchem.5b01240
	2585	790	100	None	-18	22	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	522	790	100	None	-18	22	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	551	790	100	None	-18	22	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	CHEMBL723	790	100	None	-18	22	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	DB01136	790	100	None	-18	22	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	2389	3279	114	None	-63	67	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	5073	3279	114	None	-63	67	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	96	3279	114	None	-63	67	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	CHEMBL85	3279	114	None	-63	67	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	DB00734	3279	114	None	-63	67	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	2801	161325	56	None	-3	28	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	0	2	4.5	CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21	nan
	CHEMBL1200710	161325	56	None	-3	28	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	0	2	4.5	CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21	nan
	CHEMBL415	161325	56	None	-3	28	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	0	2	4.5	CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21	nan
	1605	2310	110	None	-1	4	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
	3957	2310	110	None	-1	4	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
	7216	2310	110	None	-1	4	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
	CHEMBL998	2310	110	None	-1	4	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
	DB00455	2310	110	None	-1	4	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
	45482789	197247	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	428	4	2	2	4.5	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C(=O)Nc2ccccc2)C1	10.1016/j.bmcl.2009.09.002
	CHEMBL584554	197247	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	428	4	2	2	4.5	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C(=O)Nc2ccccc2)C1	10.1016/j.bmcl.2009.09.002
	122185011	122049	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	339	3	0	3	5.0	COc1ccc2c([C@H]3CCc4ccc(Cl)cc43)nccc2c1OC	10.1039/C4MD00113C
	CHEMBL3601563	122049	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	339	3	0	3	5.0	COc1ccc2c([C@H]3CCc4ccc(Cl)cc43)nccc2c1OC	10.1039/C4MD00113C
	11080	28872	74	None	-6	6	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
	CHEMBL1381098	28872	74	None	-6	6	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
	3151	1434	93	None	-125	26	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
	945	1434	93	None	-125	26	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
	965	1434	93	None	-125	26	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
	CHEMBL219916	1434	93	None	-125	26	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
	DB01184	1434	93	None	-125	26	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
	5818	3734	42	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 5-HT2B receptor (unknown origin)Inhibition of 5-HT2B receptor (unknown origin)	ChEMBL	394	8	1	5	3.8	COc1cc(/C=C/C(=O)NCCn2c(C)cc3c2cccc3)cc(c1OC)OC	10.1021/jm401431x
	5886965	3734	42	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 5-HT2B receptor (unknown origin)Inhibition of 5-HT2B receptor (unknown origin)	ChEMBL	394	8	1	5	3.8	COc1cc(/C=C/C(=O)NCCn2c(C)cc3c2cccc3)cc(c1OC)OC	10.1021/jm401431x
	CHEMBL1368005	3734	42	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 5-HT2B receptor (unknown origin)Inhibition of 5-HT2B receptor (unknown origin)	ChEMBL	394	8	1	5	3.8	COc1cc(/C=C/C(=O)NCCn2c(C)cc3c2cccc3)cc(c1OC)OC	10.1021/jm401431x
	76072440	148818	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	393	6	0	4	3.6	CC(C)N1CC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)OC1=O	nan
	CHEMBL3945224	148818	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	393	6	0	4	3.6	CC(C)N1CC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)OC1=O	nan
	1227	2454	35	None	-112	11	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
	2331	2454	35	None	-112	11	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
	3957	2454	35	None	-112	11	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
	4992	2454	35	None	-112	11	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
	CHEMBL511	2454	35	None	-112	11	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
	DB06691	2454	35	None	-112	11	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
	42636941	178371	0	None	-	1	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptorDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor	ChEMBL	343	5	0	5	4.4	CCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1	10.1016/j.bmc.2008.11.045
	CHEMBL470432	178371	0	None	-	1	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptorDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor	ChEMBL	343	5	0	5	4.4	CCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1	10.1016/j.bmc.2008.11.045
	1524	2150	89	None	-218	51	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
	197	2150	89	None	-218	51	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
	3822	2150	89	None	-218	51	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
	88	2150	89	None	-218	51	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
	CHEMBL51	2150	89	None	-218	51	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
	DB12465	2150	89	None	-218	51	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
	119584	2557	99	None	1	6	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
	1848	2557	99	None	1	6	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
	242	2557	99	None	1	6	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
	CHEMBL60889	2557	99	None	1	6	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
	DB11675	2557	99	None	1	6	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
	76072443	151046	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	391	6	0	4	3.4	O=C1OC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)CN1C1CC1	nan
	CHEMBL3963333	151046	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	391	6	0	4	3.4	O=C1OC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)CN1C1CC1	nan
	11957541	1430	38	None	-1	15	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2013.03.016
	1229	1430	38	None	-1	15	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2013.03.016
	147	1430	38	None	-1	15	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2013.03.016
	170617	1430	38	None	-1	15	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2013.03.016
	CHEMBL6616	1430	38	None	-1	15	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2013.03.016
	11957541	1430	38	None	-1	15	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
	1229	1430	38	None	-1	15	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
	147	1430	38	None	-1	15	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
	170617	1430	38	None	-1	15	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
	CHEMBL6616	1430	38	None	-1	15	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
	72548703	161019	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]+/-DOI from human recombinant 5-HT2B receptor after 60 mins by scintillation counting analysisDisplacement of [125I]+/-DOI from human recombinant 5-HT2B receptor after 60 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
	CHEMBL4128926	161019	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]+/-DOI from human recombinant 5-HT2B receptor after 60 mins by scintillation counting analysisDisplacement of [125I]+/-DOI from human recombinant 5-HT2B receptor after 60 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
	1043	1552	13	None	-22	28	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	149	1552	13	None	-22	28	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	8223	1552	13	None	-22	28	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	CHEMBL442	1552	13	None	-22	28	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	DB00696	1552	13	None	-22	28	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	23027527	195117	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	371	5	2	5	3.1	Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3ccc(F)cc3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
	CHEMBL565551	195117	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	371	5	2	5	3.1	Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3ccc(F)cc3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
	23027411	196843	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	387	5	2	5	3.7	Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)cc3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
	CHEMBL577912	196843	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	387	5	2	5	3.7	Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)cc3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
	5318	15400	44	None	-1	13	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL1200348	15400	44	None	-1	13	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL1221	15400	44	None	-1	13	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	1531	2235	64	None	-16	14	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
	3869	2235	64	None	-16	14	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
	7207	2235	64	None	-16	14	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
	CHEMBL429	2235	64	None	-16	14	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
	DB00598	2235	64	None	-16	14	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
	124	2933	44	None	-181	32	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
	2032	2933	44	None	-181	32	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
	4636	2933	44	None	-181	32	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
	CHEMBL762	2933	44	None	-181	32	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
	DB00935	2933	44	None	-181	32	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
	45485062	195492	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	367	5	2	5	3.3	Cc1cccc(C(=O)N[C@H]2CC[C@@H](Nc3ncc(C)c(N(C)C)n3)CC2)c1	10.1016/j.bmcl.2009.09.003
	CHEMBL567993	195492	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	367	5	2	5	3.3	Cc1cccc(C(=O)N[C@H]2CC[C@@H](Nc3ncc(C)c(N(C)C)n3)CC2)c1	10.1016/j.bmcl.2009.09.003
	44404883	71718	26	None	-2	4	Human	7.5	pIC50	=	7.5	Binding	Modulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assayModulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assay	ChEMBL	218	3	1	3	2.0	CN(C)CCc1cn(C)c2cccc(O)c12	10.1021/acsmedchemlett.1c00578
	CHEMBL197664	71718	26	None	-2	4	Human	7.5	pIC50	=	7.5	Binding	Modulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assayModulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assay	ChEMBL	218	3	1	3	2.0	CN(C)CCc1cn(C)c2cccc(O)c12	10.1021/acsmedchemlett.1c00578
	15987265	195212	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	503	6	2	5	5.3	Cc1cnc(N[C@H]2CC[C@@H](CNC(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
	CHEMBL566075	195212	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	503	6	2	5	5.3	Cc1cnc(N[C@H]2CC[C@@H](CNC(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
	3191	102385	93	None	-7	25	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
	CHEMBL305660	102385	93	None	-7	25	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
	448537	159703	86	None	-21	25	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
	CHEMBL411	159703	86	None	-21	25	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
	5897	104732	71	None	-1	3	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	223	1	1	1	3.2	CC(=O)Nc1ccc2c(c1)Cc1ccccc1-2	nan
	CHEMBL311469	104732	71	None	-1	3	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	223	1	1	1	3.2	CC(=O)Nc1ccc2c(c1)Cc1ccccc1-2	nan
	72197486	102030	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-lysergic acid from human recombinant 5HT-2B receptorDisplacement of [3H]-lysergic acid from human recombinant 5HT-2B receptor	ChEMBL	364	4	2	4	4.2	Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393245	102030	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-lysergic acid from human recombinant 5HT-2B receptorDisplacement of [3H]-lysergic acid from human recombinant 5HT-2B receptor	ChEMBL	364	4	2	4	4.2	Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL3040361	102030	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-lysergic acid from human recombinant 5HT-2B receptorDisplacement of [3H]-lysergic acid from human recombinant 5HT-2B receptor	ChEMBL	364	4	2	4	4.2	Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	45484995	196842	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	403	6	2	5	3.5	Cc1cnc(N[C@H]2CC[C@@H](CNC(=O)c3ccc(F)c(F)c3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
	CHEMBL577904	196842	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	403	6	2	5	3.5	Cc1cnc(N[C@H]2CC[C@@H](CNC(=O)c3ccc(F)c(F)c3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
	127048335	140062	0	None	15	3	Human	6.5	pIC50	=	6.5	Binding	Antagonist activity at human 5-HT2B receptor by PDSP assayAntagonist activity at human 5-HT2B receptor by PDSP assay	ChEMBL	525	12	0	5	5.9	COc1ccc(CCN(CCCc2ccccc2Br)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3813726	140062	0	None	15	3	Human	6.5	pIC50	=	6.5	Binding	Antagonist activity at human 5-HT2B receptor by PDSP assayAntagonist activity at human 5-HT2B receptor by PDSP assay	ChEMBL	525	12	0	5	5.9	COc1ccc(CCN(CCCc2ccccc2Br)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	196129	67456	12	None	-26	15	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
	CHEMBL1909065	67456	12	None	-26	15	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
	4011	81996	43	None	-20	23	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
	CHEMBL21731	81996	43	None	-20	23	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
	4601	205020	29	None	-4	17	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
	CHEMBL1201023	205020	29	None	-4	17	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
	CHEMBL900	205020	29	None	-4	17	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
	68617	203816	60	None	-15	25	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	CHEMBL1709	203816	60	None	-15	25	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	CHEMBL809	203816	60	None	-15	25	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	165193	3138	60	None	-72	42	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	2303	3138	60	None	-72	42	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	4946	3138	60	None	-72	42	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	564	3138	60	None	-72	42	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	62882	3138	60	None	-72	42	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	63	3138	60	None	-72	42	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	66366	3138	60	None	-72	42	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	91536	3138	60	None	-72	42	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	CHEMBL27	3138	60	None	-72	42	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	CHEMBL452861	3138	60	None	-72	42	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	DB00571	3138	60	None	-72	42	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	2353	100643	75	None	-7	5	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	336	2	0	4	3.1	COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2	nan
	CHEMBL12089	100643	75	None	-7	5	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	336	2	0	4	3.1	COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2	nan
	CHEMBL295124	100643	75	None	-7	5	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	336	2	0	4	3.1	COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2	nan
	3117	206106	100	None	-8	16	Human	4.5	pIC50	=	4.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
	CHEMBL964	206106	100	None	-8	16	Human	4.5	pIC50	=	4.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
	2284	3133	27	None	-16	28	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	4926	3133	27	None	-16	28	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	7281	3133	27	None	-16	28	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	CHEMBL564	3133	27	None	-16	28	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	DB00420	3133	27	None	-16	28	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	11304816	65947	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibitory activity against human 5-HT2B receptorInhibitory activity against human 5-HT2B receptor	ChEMBL	424	5	1	5	4.0	Cc1cc(N2CCN(C)CC2)nc2ccc(NC(=O)COc3ccc(Cl)cc3)cc12	10.1016/j.bmcl.2004.05.051
	CHEMBL184717	65947	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibitory activity against human 5-HT2B receptorInhibitory activity against human 5-HT2B receptor	ChEMBL	424	5	1	5	4.0	Cc1cc(N2CCN(C)CC2)nc2ccc(NC(=O)COc3ccc(Cl)cc3)cc12	10.1016/j.bmcl.2004.05.051
	11536844	114624	0	None	1	2	Human	7.5	pIC50	=	7.5	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolismAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolism	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343672	114624	0	None	1	2	Human	7.5	pIC50	=	7.5	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolismAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolism	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	2351	3234	60	None	-7	21	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	2820	3234	60	None	-7	21	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	5035	3234	60	None	-7	21	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	CHEMBL81	3234	60	None	-7	21	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	DB00481	3234	60	None	-7	21	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	444795	139469	102	None	3	2	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1	nan
	CHEMBL38	139469	102	None	3	2	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1	nan
	26987	936	29	None	-47	21	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	6063	936	29	None	-47	21	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	671	936	29	None	-47	21	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	CHEMBL1626	936	29	None	-47	21	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	DB00283	936	29	None	-47	21	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	72734860	103480	0	None	6	5	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysisAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3092753	103480	0	None	6	5	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysisAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
	3973	206439	104	None	-44	3	Human	4.4	pIC50	=	4.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	2	0	4	3.3	O=c1cc(N2CCOCC2)oc2c(-c3ccccc3)cccc12	nan
	CHEMBL98350	206439	104	None	-44	3	Human	4.4	pIC50	=	4.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	2	0	4	3.3	O=c1cc(N2CCOCC2)oc2c(-c3ccccc3)cccc12	nan
	3157	1442	69	None	-37	12	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
	7170	1442	69	None	-37	12	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
	954	1442	69	None	-37	12	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
	CHEMBL707	1442	69	None	-37	12	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
	DB00590	1442	69	None	-37	12	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
	58438464	3016	28	None	-	3	Human	5.4	pIC50	=	5.4	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	9060	3016	28	None	-	3	Human	5.4	pIC50	=	5.4	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	CHEMBL3287218	3016	28	None	-	3	Human	5.4	pIC50	=	5.4	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	DB14870	3016	28	None	-	3	Human	5.4	pIC50	=	5.4	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	6726	1254	46	None	-7	13	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	7151	1254	46	None	-7	13	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	749	1254	46	None	-7	13	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	CHEMBL648	1254	46	None	-7	13	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	DB01176	1254	46	None	-7	13	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	118112300	155453	12	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at 5HT2B (unknown origin)Antagonist activity at 5HT2B (unknown origin)	ChEMBL	430	6	2	6	3.8	O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC23CCCN2CCC3)cc1F	10.1016/j.bmcl.2017.03.085
	CHEMBL4061793	155453	12	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at 5HT2B (unknown origin)Antagonist activity at 5HT2B (unknown origin)	ChEMBL	430	6	2	6	3.8	O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC23CCCN2CCC3)cc1F	10.1016/j.bmcl.2017.03.085
	2142	3047	54	None	-43	36	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
	4920903	3047	54	None	-43	36	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
	502	3047	54	None	-43	36	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
	5775	3047	54	None	-43	36	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
	CHEMBL597	3047	54	None	-43	36	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
	DB00692	3047	54	None	-43	36	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
	1212	1632	45	None	-27	65	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	204	1632	45	None	-27	65	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	3372	1632	45	None	-27	65	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	CHEMBL726	1632	45	None	-27	65	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	DB00623	1632	45	None	-27	65	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	11957541	1430	38	None	-1	15	Human	8.4	pIC50	=	8.4	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
	1229	1430	38	None	-1	15	Human	8.4	pIC50	=	8.4	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
	147	1430	38	None	-1	15	Human	8.4	pIC50	=	8.4	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
	170617	1430	38	None	-1	15	Human	8.4	pIC50	=	8.4	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
	CHEMBL6616	1430	38	None	-1	15	Human	8.4	pIC50	=	8.4	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
	1042	1551	20	None	-7	16	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	148	1551	20	None	-7	16	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	443884	1551	20	None	-7	16	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	CHEMBL119443	1551	20	None	-7	16	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	DB01253	1551	20	None	-7	16	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	44393215	66330	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against human 5-HT2B receptorInhibitory activity against human 5-HT2B receptor	ChEMBL	417	6	2	4	5.4	Cc1cc(NC(C)C)nc2ccc(NC(=O)COc3ccc(C(F)(F)F)cc3)cc12	10.1016/j.bmcl.2004.05.051
	CHEMBL185376	66330	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against human 5-HT2B receptorInhibitory activity against human 5-HT2B receptor	ChEMBL	417	6	2	4	5.4	Cc1cc(NC(C)C)nc2ccc(NC(=O)COc3ccc(C(F)(F)F)cc3)cc12	10.1016/j.bmcl.2004.05.051
	74538762	143009	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	419	6	0	4	4.2	O=C1OC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)CN1C1CCCC1	nan
	CHEMBL3898995	143009	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	419	6	0	4	4.2	O=C1OC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)CN1C1CCCC1	nan
	1599	2309	47	None	-144	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
	3955	2309	47	None	-144	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
	7215	2309	47	None	-144	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
	CHEMBL841	2309	47	None	-144	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
	DB00836	2309	47	None	-144	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
	165193	3138	60	None	-72	42	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	2303	3138	60	None	-72	42	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	4946	3138	60	None	-72	42	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	564	3138	60	None	-72	42	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	62882	3138	60	None	-72	42	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	63	3138	60	None	-72	42	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	66366	3138	60	None	-72	42	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	91536	3138	60	None	-72	42	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	CHEMBL27	3138	60	None	-72	42	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	CHEMBL452861	3138	60	None	-72	42	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	DB00571	3138	60	None	-72	42	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	4209	3114	71	None	-758	33	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
	4893	3114	71	None	-758	33	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
	503	3114	71	None	-758	33	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
	5385	3114	71	None	-758	33	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
	CHEMBL2	3114	71	None	-758	33	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
	DB00457	3114	71	None	-758	33	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
	CHEMBL5079070	212832	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Modulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assayModulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assay	ChEMBL		None	None	None		CC(C)N(C)CCc1cn(C)c2cccc(O)c12	10.1021/acsmedchemlett.1c00578
	124087	1362	106	None	-5	15	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	7157	1362	106	None	-5	15	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	814	1362	106	None	-5	15	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	CHEMBL1172	1362	106	None	-5	15	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	DB00967	1362	106	None	-5	15	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	72198754	90449	0	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	443	8	0	4	4.8	COc1ccccc1N1CCN(CCCCCN2Cc3ccc4ccccc4c3C2=O)CC1	10.1016/j.ejmech.2013.01.044
	CHEMBL2392349	90449	0	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	443	8	0	4	4.8	COc1ccccc1N1CCN(CCCCCN2Cc3ccc4ccccc4c3C2=O)CC1	10.1016/j.ejmech.2013.01.044
	58438475	91841	0	None	-	2	Human	5.4	pIC50	=	5.4	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml500414n
	CHEMBL2426677	91841	0	None	-	2	Human	5.4	pIC50	=	5.4	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml500414n
	21138	97999	34	None	-6	7	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	CC(C)NC[C@@H](O)COc1cccc2ccccc12	nan
	CHEMBL275742	97999	34	None	-6	7	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	CC(C)NC[C@@H](O)COc1cccc2ccccc12	nan
	10389430	125430	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against human 5-HT2B receptorInhibitory activity against human 5-HT2B receptor	ChEMBL	458	5	1	5	4.3	Cc1cc(N2CCN(C)CC2)nc2ccc(NC(=O)COc3ccc(C(F)(F)F)cc3)cc12	10.1016/j.bmcl.2004.05.051
	CHEMBL364863	125430	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against human 5-HT2B receptorInhibitory activity against human 5-HT2B receptor	ChEMBL	458	5	1	5	4.3	Cc1cc(N2CCN(C)CC2)nc2ccc(NC(=O)COc3ccc(C(F)(F)F)cc3)cc12	10.1016/j.bmcl.2004.05.051
	1530	2151	44	None	-19	20	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	3827	2151	44	None	-19	20	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	7206	2151	44	None	-19	20	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	CHEMBL534	2151	44	None	-19	20	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	DB00920	2151	44	None	-19	20	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	5353853	17803	41	None	-23	15	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	9556529	17803	41	None	-23	15	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL1262	17803	41	None	-23	15	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	2600	3720	73	None	-1	13	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	2608	3720	73	None	-1	13	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	5405	3720	73	None	-1	13	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	CHEMBL17157	3720	73	None	-1	13	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	DB00342	3720	73	None	-1	13	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	4211	57517	81	None	-2	4	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	nan
	CHEMBL1670	57517	81	None	-2	4	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	nan
	6761	67457	17	None	-7	18	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
	CHEMBL1909072	67457	17	None	-7	18	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
	1588	2294	24	None	-8	43	Human	8.3	pIC50	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	28864	2294	24	None	-8	43	Human	8.3	pIC50	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	43	2294	24	None	-8	43	Human	8.3	pIC50	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	CHEMBL157138	2294	24	None	-8	43	Human	8.3	pIC50	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	DB00589	2294	24	None	-8	43	Human	8.3	pIC50	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	206	2457	10	None	-1	24	Human	8.3	pIC50	=	8.3	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/j.ejmech.2019.04.064
	68848	2457	10	None	-1	24	Human	8.3	pIC50	=	8.3	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/j.ejmech.2019.04.064
	CHEMBL12314	2457	10	None	-1	24	Human	8.3	pIC50	=	8.3	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/j.ejmech.2019.04.064
	44516817	57358	4	None	-4365	2	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT2B receptorDisplacement of [3H]lysergic acid diethylamide from human recombinant 5HT2B receptor	ChEMBL	316	3	1	6	2.2	CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2011.01.038
	CHEMBL1668584	57358	4	None	-4365	2	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT2B receptorDisplacement of [3H]lysergic acid diethylamide from human recombinant 5HT2B receptor	ChEMBL	316	3	1	6	2.2	CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2011.01.038
	6075	149575	36	None	-8	16	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
	CHEMBL395110	149575	36	None	-8	16	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
	5624	32474	12	None	5	10	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
	CHEMBL1203324	32474	12	None	5	10	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
	CHEMBL141343	32474	12	None	5	10	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
	11694810	120028	0	None	1	3	Human	7.3	pIC50	=	7.3	Binding	Inhibition of human 5-HT2B receptor expressed in HEK293-EBNA cells assessed as [3H]PI metabolism by by liquid scintillation countingInhibition of human 5-HT2B receptor expressed in HEK293-EBNA cells assessed as [3H]PI metabolism by by liquid scintillation counting	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3310123	120028	0	None	1	3	Human	7.3	pIC50	=	7.3	Binding	Inhibition of human 5-HT2B receptor expressed in HEK293-EBNA cells assessed as [3H]PI metabolism by by liquid scintillation countingInhibition of human 5-HT2B receptor expressed in HEK293-EBNA cells assessed as [3H]PI metabolism by by liquid scintillation counting	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3545474	120028	0	None	1	3	Human	7.3	pIC50	=	7.3	Binding	Inhibition of human 5-HT2B receptor expressed in HEK293-EBNA cells assessed as [3H]PI metabolism by by liquid scintillation countingInhibition of human 5-HT2B receptor expressed in HEK293-EBNA cells assessed as [3H]PI metabolism by by liquid scintillation counting	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	44592109	178509	0	None	-	1	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptorDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor	ChEMBL	343	6	0	5	4.4	CCCCN1CCC(COc2nc3ccsc3n3cccc23)CC1	10.1016/j.bmc.2008.11.045
	CHEMBL471663	178509	0	None	-	1	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptorDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor	ChEMBL	343	6	0	5	4.4	CCCCN1CCC(COc2nc3ccsc3n3cccc23)CC1	10.1016/j.bmc.2008.11.045
	169713	79751	17	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	309	3	2	2	2.6	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2NC1	10.1016/j.bmcl.2009.09.002
	CHEMBL21343	79751	17	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	309	3	2	2	2.6	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2NC1	10.1016/j.bmcl.2009.09.002
	4943	192814	100	None	1	2	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	178	2	1	1	3.6	CC(C)c1cccc(C(C)C)c1O	nan
	CHEMBL526	192814	100	None	1	2	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	178	2	1	1	3.6	CC(C)c1cccc(C(C)C)c1O	nan
	11500509	120070	0	None	-3	3	Human	7.3	pIC50	=	7.3	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolismAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolism	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343670	120070	0	None	-3	3	Human	7.3	pIC50	=	7.3	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolismAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolism	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3545812	120070	0	None	-3	3	Human	7.3	pIC50	=	7.3	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolismAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolism	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	4189	205195	91	None	-26	34	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL1559	205195	91	None	-26	34	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL91	205195	91	None	-26	34	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	2683	102415	24	None	-501	16	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	CHEMBL305906	102415	24	None	-501	16	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	CHEMBL334255	102415	24	None	-501	16	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	3598	187238	73	None	-2	7	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	nan
	CHEMBL496	187238	73	None	-2	7	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	nan
	135398745	2869	108	None	-5	65	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
	47	2869	108	None	-5	65	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
	CHEMBL715	2869	108	None	-5	65	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
	DB00334	2869	108	None	-5	65	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
	107715	199260	18	None	-14	20	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
	CHEMBL1255837	199260	18	None	-14	20	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
	CHEMBL601773	199260	18	None	-14	20	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
	122196341	123754	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to human 5HT2bBinding affinity to human 5HT2b	ChEMBL	422	5	1	3	6.0	O=c1ccc(-c2ccc(OCc3ccc4ccccc4n3)cc2)c(-c2ccc(F)cc2)[nH]1	10.1021/acs.jmedchem.5b01240
	CHEMBL3634745	123754	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to human 5HT2bBinding affinity to human 5HT2b	ChEMBL	422	5	1	3	6.0	O=c1ccc(-c2ccc(OCc3ccc4ccccc4n3)cc2)c(-c2ccc(F)cc2)[nH]1	10.1021/acs.jmedchem.5b01240
	10531	1392	18	None	-15	24	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	121	1392	18	None	-15	24	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	888	1392	18	None	-15	24	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	CHEMBL1732	1392	18	None	-15	24	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	DB00320	1392	18	None	-15	24	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	1836	2554	56	None	-69	15	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
	3340	2554	56	None	-69	15	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
	5281040	2554	56	None	-69	15	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
	CHEMBL787	2554	56	None	-69	15	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
	DB00471	2554	56	None	-69	15	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
	14049689	196766	8	None	20	2	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	1541	28	21	42	-12.4	CC(O)COC[C@H]1O[C@@H]2O[C@@H]3[C@@H](COCC(C)O)O[C@H](O[C@@H]4[C@@H](COCC(C)O)O[C@H](O[C@@H]5[C@@H](COCC(C)O)O[C@H](O[C@@H]6[C@@H](COCC(C)O)O[C@H](O[C@@H]7[C@@H](COCC(C)O)O[C@H](O[C@@H]8[C@@H](COCC(C)O)O[C@H](O[C@H]1[C@H](O)[C@H]2O)[C@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O	nan
	CHEMBL577294	196766	8	None	20	2	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	1541	28	21	42	-12.4	CC(O)COC[C@H]1O[C@@H]2O[C@@H]3[C@@H](COCC(C)O)O[C@H](O[C@@H]4[C@@H](COCC(C)O)O[C@H](O[C@@H]5[C@@H](COCC(C)O)O[C@H](O[C@@H]6[C@@H](COCC(C)O)O[C@H](O[C@@H]7[C@@H](COCC(C)O)O[C@H](O[C@@H]8[C@@H](COCC(C)O)O[C@H](O[C@H]1[C@H](O)[C@H]2O)[C@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O	nan
	72198756	90451	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	478	8	0	5	4.8	COc1ccccc1N1CCN(CCCCCN2Cc3c(Cl)nc4ccccc4c3C2=O)CC1	10.1016/j.ejmech.2013.01.044
	CHEMBL2392351	90451	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	478	8	0	5	4.8	COc1ccccc1N1CCN(CCCCCN2Cc3c(Cl)nc4ccccc4c3C2=O)CC1	10.1016/j.ejmech.2013.01.044
	1782	2482	81	None	-3	22	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
	241	2482	81	None	-3	22	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
	4168	2482	81	None	-3	22	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
	CHEMBL86	2482	81	None	-3	22	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
	DB01233	2482	81	None	-3	22	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
	72713752	103268	0	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	396	5	2	7	3.0	Cc1csc(C(C)(O)c2nnc(NC(=O)Cc3c(F)cccc3F)s2)n1	10.1021/jm4012033
	CHEMBL3088176	103268	0	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	396	5	2	7	3.0	Cc1csc(C(C)(O)c2nnc(NC(=O)Cc3c(F)cccc3F)s2)n1	10.1021/jm4012033
	90644511	111174	13	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	282	3	2	4	2.4	CNc1nc(Cc2ccccc2)nc2c1CCNC[C@@H]2C	10.1021/jm5003292
	CHEMBL3286556	111174	13	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	282	3	2	4	2.4	CNc1nc(Cc2ccccc2)nc2c1CCNC[C@@H]2C	10.1021/jm5003292
	2406	99938	84	None	-27	12	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	nan
	CHEMBL290106	99938	84	None	-27	12	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	nan
	2286	3134	48	None	-5	29	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	4927	3134	48	None	-5	29	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	7282	3134	48	None	-5	29	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	CHEMBL643	3134	48	None	-5	29	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	DB01069	3134	48	None	-5	29	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	3198	203802	73	None	-30	34	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL1201049	203802	73	None	-30	34	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL808	203802	73	None	-30	34	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	135	2496	38	None	-3	57	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	1796	2496	38	None	-3	57	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	4184	2496	38	None	-3	57	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	CHEMBL6437	2496	38	None	-3	57	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	DB06148	2496	38	None	-3	57	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	180	397	50	None	-35	38	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	200	397	50	None	-35	38	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	2160	397	50	None	-35	38	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	CHEMBL629	397	50	None	-35	38	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	DB00321	397	50	None	-35	38	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	4595	176141	102	None	2	15	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	nan
	CHEMBL46	176141	102	None	2	15	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	nan
	11536843	114625	0	None	1	2	Human	7.1	pIC50	=	7.1	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolismAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolism	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343673	114625	0	None	1	2	Human	7.1	pIC50	=	7.1	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolismAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolism	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	1547484	927	70	None	-8	20	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	654	927	70	None	-8	20	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	9072	927	70	None	-8	20	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	CHEMBL43064	927	70	None	-8	20	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	DB00568	927	70	None	-8	20	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	102	4064	44	None	-93	49	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
	3659	4064	44	None	-93	49	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
	8969	4064	44	None	-93	49	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
	CHEMBL15245	4064	44	None	-93	49	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
	DB01392	4064	44	None	-93	49	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
	2477	734	54	None	-13	28	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
	36	734	54	None	-13	28	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
	437	734	54	None	-13	28	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
	CHEMBL49	734	54	None	-13	28	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
	DB00490	734	54	None	-13	28	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
	71499384	110661	36	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5-HT2B receptor (unknown origin)Inhibition of 5-HT2B receptor (unknown origin)	ChEMBL	448	8	1	5	4.5	COc1cc(/C=C/C(=O)NCCn2c(C(F)(F)F)cc3ccccc32)cc(OC)c1OC	10.1021/jm401431x
	CHEMBL3264204	110661	36	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5-HT2B receptor (unknown origin)Inhibition of 5-HT2B receptor (unknown origin)	ChEMBL	448	8	1	5	4.5	COc1cc(/C=C/C(=O)NCCn2c(C(F)(F)F)cc3ccccc32)cc(OC)c1OC	10.1021/jm401431x
	2105	3005	34	None	-28	33	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	47811	3005	34	None	-28	33	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	48	3005	34	None	-28	33	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	CHEMBL531	3005	34	None	-28	33	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	DB01186	3005	34	None	-28	33	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	67406727	116690	0	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	525	6	1	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
	CHEMBL3394201	116690	0	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	525	6	1	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
	11957735	198338	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	350	4	1	5	4.0	CN(C)Cc1nc(-c2ccc(C(C)(C)C)cc2)n(-c2cccc(O)c2)n1	10.1016/j.bmc.2009.07.007
	CHEMBL595449	198338	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	350	4	1	5	4.0	CN(C)Cc1nc(-c2ccc(C(C)(C)C)cc2)n(-c2cccc(O)c2)n1	10.1016/j.bmc.2009.07.007
	2028	2931	77	None	-40	11	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	359	2931	77	None	-40	11	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	4634	2931	77	None	-40	11	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	CHEMBL1231	2931	77	None	-40	11	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	DB01062	2931	77	None	-40	11	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	31101	720	39	None	-26	35	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	35	720	39	None	-26	35	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	403	720	39	None	-26	35	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	CHEMBL493	720	39	None	-26	35	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	DB01200	720	39	None	-26	35	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	161	743	3	None	2	6	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	nan
	4284720	743	3	None	2	6	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	nan
	CHEMBL1255834	743	3	None	2	6	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	nan
	54764240	68526	0	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	242	1	1	2	2.7	CC/C=C1\C[C@H]2CNc3ccccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
	CHEMBL1922539	68526	0	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	242	1	1	2	2.7	CC/C=C1\C[C@H]2CNc3ccccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
	CHEMBL5085055	213173	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Modulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assayModulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assay	ChEMBL		None	None	None		CCN(C)CCc1cn(C)c2cccc(O)c12	10.1021/acsmedchemlett.1c00578
	4098	32289	24	None	-14	11	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
	CHEMBL1255739	32289	24	None	-14	11	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
	CHEMBL1411979	32289	24	None	-14	11	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
	54764241	68525	0	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	258	1	1	3	2.3	C/C=C1\C[C@H]2CNc3c(OC)cccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
	CHEMBL1922538	68525	0	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	258	1	1	3	2.3	C/C=C1\C[C@H]2CNc3c(OC)cccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
	5282379	193314	64	None	1	3	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C\C(=O)O)C(C)(C)CCC1	nan
	CHEMBL547	193314	64	None	1	3	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C\C(=O)O)C(C)(C)CCC1	nan
	146420029	184179	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	379	3	1	3	4.2	CN1CCC(=C(F)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1	10.1016/j.ejmech.2021.113782
	CHEMBL4851044	184179	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	379	3	1	3	4.2	CN1CCC(=C(F)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1	10.1016/j.ejmech.2021.113782
	3158	55974	21	None	-389	20	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
	CHEMBL1628227	55974	21	None	-389	20	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
	72197484	102021	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-lysergic acid from human recombinant 5HT-2B receptorDisplacement of [3H]-lysergic acid from human recombinant 5HT-2B receptor	ChEMBL	330	4	2	4	3.5	c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393243	102021	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-lysergic acid from human recombinant 5HT-2B receptorDisplacement of [3H]-lysergic acid from human recombinant 5HT-2B receptor	ChEMBL	330	4	2	4	3.5	c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
	CHEMBL3040324	102021	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-lysergic acid from human recombinant 5HT-2B receptorDisplacement of [3H]-lysergic acid from human recombinant 5HT-2B receptor	ChEMBL	330	4	2	4	3.5	c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
	277	1274	55	None	-5	45	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	2913	1274	55	None	-5	45	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	765	1274	55	None	-5	45	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	CHEMBL516	1274	55	None	-5	45	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	DB00434	1274	55	None	-5	45	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	1305	508	10	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]LSD from human 5HT2B receptorDisplacement of [125I]LSD from human 5HT2B receptor	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2009.09.003
	9934033	508	10	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]LSD from human 5HT2B receptorDisplacement of [125I]LSD from human 5HT2B receptor	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2009.09.003
	CHEMBL182150	508	10	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]LSD from human 5HT2B receptorDisplacement of [125I]LSD from human 5HT2B receptor	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2009.09.003
	9861687	188610	0	None	-	1	Human	8.0	pIC50	=	8.0	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptorDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor	ChEMBL	315	4	0	5	3.7	CCN1CCC(COc2nc3ccsc3n3cccc23)CC1	10.1016/j.bmc.2008.11.045
	CHEMBL511312	188610	0	None	-	1	Human	8.0	pIC50	=	8.0	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptorDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor	ChEMBL	315	4	0	5	3.7	CCN1CCC(COc2nc3ccsc3n3cccc23)CC1	10.1016/j.bmc.2008.11.045
	2291	3135	52	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
	2561	3135	52	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
	4932	3135	52	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
	CHEMBL631	3135	52	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
	DB01182	3135	52	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
	176	394	63	None	-1	31	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2157	394	63	None	-1	31	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2566	394	63	None	-1	31	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	CHEMBL633	394	63	None	-1	31	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	DB01118	394	63	None	-1	31	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	657255	197406	29	None	-9	15	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	nan
	CHEMBL588119	197406	29	None	-9	15	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	nan
	3952	1857	33	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
	5353646	1857	33	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
	5443	1857	33	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
	5702063	1857	33	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
	CHEMBL1331786	1857	33	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
	CHEMBL420	1857	33	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
	24360	201653	101	None	-	1	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	348	1	1	6	2.1	CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3ccccc3nc2-1	nan
	CHEMBL65	201653	101	None	-	1	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	348	1	1	6	2.1	CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3ccccc3nc2-1	nan
	127048334	140070	0	None	13	3	Human	7.0	pIC50	=	7	Binding	Antagonist activity at human 5-HT2B receptor by PDSP assayAntagonist activity at human 5-HT2B receptor by PDSP assay	ChEMBL	481	12	0	5	5.8	COc1ccc(CCN(CCCc2ccccc2Cl)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3813796	140070	0	None	13	3	Human	7.0	pIC50	=	7	Binding	Antagonist activity at human 5-HT2B receptor by PDSP assayAntagonist activity at human 5-HT2B receptor by PDSP assay	ChEMBL	481	12	0	5	5.8	COc1ccc(CCN(CCCc2ccccc2Cl)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	10851262	40318	0	None	1	2	Rat	8.9	pKd	=	8.9	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	293	1	1	3	3.7	Cc1coc2cc3c(cc12)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
	CHEMBL148346	40318	0	None	1	2	Rat	8.9	pKd	=	8.9	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	293	1	1	3	3.7	Cc1coc2cc3c(cc12)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
	9972439	40370	0	None	-1	2	Rat	8.0	pKd	=	8	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	306	2	1	3	3.7	CCn1ccc2cc3c(cc21)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
	CHEMBL148385	40370	0	None	-1	2	Rat	8.0	pKd	=	8	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	306	2	1	3	3.7	CCn1ccc2cc3c(cc21)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
	10851406	118759	1	None	-1	2	Rat	8.0	pKd	=	8	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	295	1	1	3	3.9	O=C(Nc1cccnc1)N1CCc2cc3sccc3cc21	10.1021/jm960571v
	CHEMBL343666	118759	1	None	-1	2	Rat	8.0	pKd	=	8	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	295	1	1	3	3.9	O=C(Nc1cccnc1)N1CCc2cc3sccc3cc21	10.1021/jm960571v
	141	1399	32	None	-11	21	Rat	6.0	pKd	=	6	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/jm00343a013
	6089	1399	32	None	-11	21	Rat	6.0	pKd	=	6	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/jm00343a013
	CHEMBL12420	1399	32	None	-11	21	Rat	6.0	pKd	=	6	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/jm00343a013
	DB01488	1399	32	None	-11	21	Rat	6.0	pKd	=	6	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/jm00343a013
	12281266	31616	4	None	-	1	Rat	7.0	pKd	=	7.0	Binding	Compound was tested for serotonin receptor affinity by the displacement of [3H]- -5-HT binding to rat fundus membranes.Compound was tested for serotonin receptor affinity by the displacement of [3H]- -5-HT binding to rat fundus membranes.	ChEMBL	187	3	0	1	3.7	CC(C)CCn1ccc2ccccc21	10.1021/jm00367a008
	CHEMBL140663	31616	4	None	-	1	Rat	7.0	pKd	=	7.0	Binding	Compound was tested for serotonin receptor affinity by the displacement of [3H]- -5-HT binding to rat fundus membranes.Compound was tested for serotonin receptor affinity by the displacement of [3H]- -5-HT binding to rat fundus membranes.	ChEMBL	187	3	0	1	3.7	CC(C)CCn1ccc2ccccc21	10.1021/jm00367a008
	6088	119337	54	None	-	1	Rat	6.0	pKd	=	6.0	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	174	3	2	1	1.9	CNCCc1c[nH]c2ccccc12	10.1021/jm00343a013
	CHEMBL348588	119337	54	None	-	1	Rat	6.0	pKd	=	6.0	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	174	3	2	1	1.9	CNCCc1c[nH]c2ccccc12	10.1021/jm00343a013
	10637557	36042	0	None	5	2	Rat	7.9	pKd	=	7.9	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	294	1	1	3	2.7	CN1CCc2cc3c(cc21)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
	CHEMBL144567	36042	0	None	5	2	Rat	7.9	pKd	=	7.9	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	294	1	1	3	2.7	CN1CCc2cc3c(cc21)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
	152234	55732	20	None	-	1	Rat	5.9	pKd	=	5.9	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	165	3	1	2	1.6	COc1cccc(CC(C)N)c1	10.1021/jm00144a009
	CHEMBL16247	55732	20	None	-	1	Rat	5.9	pKd	=	5.9	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	165	3	1	2	1.6	COc1cccc(CC(C)N)c1	10.1021/jm00144a009
	44359526	116131	1	None	-	1	Rat	6.9	pKd	=	6.9	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	217	4	0	2	3.7	COc1ccc2c(ccn2CCC(C)C)c1	10.1021/jm00367a008
	CHEMBL336928	116131	1	None	-	1	Rat	6.9	pKd	=	6.9	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	217	4	0	2	3.7	COc1ccc2c(ccn2CCC(C)C)c1	10.1021/jm00367a008
	44359525	28658	1	None	-	1	Rat	6.9	pKd	=	6.9	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	201	3	0	1	4.0	Cc1ccc2ccn(CCC(C)C)c2c1	10.1021/jm00367a008
	CHEMBL137933	28658	1	None	-	1	Rat	6.9	pKd	=	6.9	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	201	3	0	1	4.0	Cc1ccc2ccn(CCC(C)C)c2c1	10.1021/jm00367a008
	805647	30595	11	None	-	1	Rat	6.9	pKd	=	6.9	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	189	3	0	3	1.6	CN(C)CCn1cnc2ccccc21	10.1021/jm00367a008
	CHEMBL139655	30595	11	None	-	1	Rat	6.9	pKd	=	6.9	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	189	3	0	3	1.6	CN(C)CCn1cnc2ccccc21	10.1021/jm00367a008
	143435	99233	4	None	-	1	Rat	5.9	pKd	=	5.9	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	209	4	1	3	1.9	COc1cc(C)c(CC(C)N)cc1OC	10.1021/jm00144a009
	CHEMBL284589	99233	4	None	-	1	Rat	5.9	pKd	=	5.9	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	209	4	1	3	1.9	COc1cc(C)c(CC(C)N)cc1OC	10.1021/jm00144a009
	62787	204467	17	None	-3	9	Rat	6.8	pKd	=	6.8	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1ccc(OC)c(CC(C)N)c1	10.1021/jm00144a009
	CHEMBL8642	204467	17	None	-3	9	Rat	6.8	pKd	=	6.8	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1ccc(OC)c(CC(C)N)c1	10.1021/jm00144a009
	9904139	106510	0	None	1	4	Rat	7.8	pKd	=	7.8	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	292	1	1	3	3.2	Cn1ccc2c3c(ccc21)N(C(=O)Nc1cccnc1)CC3	10.1021/jm960571v
	CHEMBL315223	106510	0	None	1	4	Rat	7.8	pKd	=	7.8	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	292	1	1	3	3.2	Cn1ccc2c3c(ccc21)N(C(=O)Nc1cccnc1)CC3	10.1021/jm960571v
	31014	204175	16	None	2	3	Rat	6.8	pKd	=	6.8	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	225	5	1	4	1.6	COc1cc(OC)c(OC)cc1CC(C)N	10.1021/jm00144a009
	CHEMBL8389	204175	16	None	2	3	Rat	6.8	pKd	=	6.8	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	225	5	1	4	1.6	COc1cc(OC)c(OC)cc1CC(C)N	10.1021/jm00144a009
	144891	106903	8	None	-	1	Rat	5.8	pKd	=	5.8	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	241	5	1	4	2.3	COc1cc(OC)c(SC)cc1CC(C)N	10.1021/jm00144a009
	CHEMBL31787	106903	8	None	-	1	Rat	5.8	pKd	=	5.8	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	241	5	1	4	2.3	COc1cc(OC)c(SC)cc1CC(C)N	10.1021/jm00144a009
	9904139	106510	0	None	1	4	Rat	7.8	pKd	=	7.8	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	292	1	1	3	3.2	Cn1ccc2c3c(ccc21)N(C(=O)Nc1cccnc1)CC3	10.1021/jm00014a004
	CHEMBL315223	106510	0	None	1	4	Rat	7.8	pKd	=	7.8	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	292	1	1	3	3.2	Cn1ccc2c3c(ccc21)N(C(=O)Nc1cccnc1)CC3	10.1021/jm00014a004
	141685	106565	4	None	-	1	Rat	5.8	pKd	=	5.8	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	273	4	1	3	2.4	COc1cc(Br)c(CC(C)N)cc1OC	10.1021/jm00144a009
	CHEMBL31557	106565	4	None	-	1	Rat	5.8	pKd	=	5.8	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	273	4	1	3	2.4	COc1cc(Br)c(CC(C)N)cc1OC	10.1021/jm00144a009
	11806221	119717	1	None	-	1	Rat	6.7	pKd	=	6.7	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	220	4	1	3	2.2	COc1ccc2c(c1)C(CCN(C)C)CN2	10.1021/jm00343a013
	CHEMBL352140	119717	1	None	-	1	Rat	6.7	pKd	=	6.7	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	220	4	1	3	2.2	COc1ccc2c(c1)C(CCN(C)C)CN2	10.1021/jm00343a013
	10757038	118729	0	None	1	2	Rat	7.7	pKd	=	7.7	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	306	1	1	3	3.5	Cc1cc2cc3c(cc2n1C)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
	CHEMBL343455	118729	0	None	1	2	Rat	7.7	pKd	=	7.7	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	306	1	1	3	3.5	Cc1cc2cc3c(cc2n1C)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
	10690384	120443	0	None	-3	2	Rat	6.7	pKd	=	6.7	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	368	3	1	3	4.7	O=C(Nc1cccnc1)N1CCc2cc3c(ccn3Cc3ccccc3)cc21	10.1021/jm960571v
	CHEMBL356146	120443	0	None	-3	2	Rat	6.7	pKd	=	6.7	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	368	3	1	3	4.7	O=C(Nc1cccnc1)N1CCc2cc3c(ccn3Cc3ccccc3)cc21	10.1021/jm960571v
	44359444	28916	0	None	-	1	Rat	7.7	pKd	=	7.7	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	217	4	0	2	3.7	COc1ccc2ccn(CCC(C)C)c2c1	10.1021/jm00367a008
	CHEMBL138144	28916	0	None	-	1	Rat	7.7	pKd	=	7.7	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	217	4	0	2	3.7	COc1ccc2ccn(CCC(C)C)c2c1	10.1021/jm00367a008
	12655251	118804	52	None	-	1	Rat	5.7	pKd	=	5.7	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	162	2	2	2	1.5	NCCC1CNc2ccccc21	10.1021/jm00367a008
	CHEMBL344028	118804	52	None	-	1	Rat	5.7	pKd	=	5.7	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	162	2	2	2	1.5	NCCC1CNc2ccccc21	10.1021/jm00367a008
	11074217	52527	4	None	-	1	Rat	5.7	pKd	=	5.7	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	190	3	1	2	2.1	CN(C)CCC1CNc2ccccc21	10.1021/jm00343a013
	CHEMBL159503	52527	4	None	-	1	Rat	5.7	pKd	=	5.7	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	190	3	1	2	2.1	CN(C)CCC1CNc2ccccc21	10.1021/jm00343a013
	547452	54506	2	None	-	1	Rat	5.7	pKd	=	5.7	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	187	3	0	1	2.6	CN(C)CCC1=CCc2ccccc21	10.1021/jm00343a013
	CHEMBL161241	54506	2	None	-	1	Rat	5.7	pKd	=	5.7	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	187	3	0	1	2.6	CN(C)CCC1=CCc2ccccc21	10.1021/jm00343a013
	12451869	54898	5	None	-	1	Rat	5.7	pKd	=	5.7	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	175	3	1	1	2.3	CNCCC1CCc2ccccc21	10.1021/jm00343a013
	CHEMBL161751	54898	5	None	-	1	Rat	5.7	pKd	=	5.7	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	175	3	1	1	2.3	CNCCC1CCc2ccccc21	10.1021/jm00343a013
	144889	98865	6	None	-	1	Rat	5.6	pKd	=	5.6	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	209	4	1	3	1.9	COc1cc(OC)c(CC(C)N)cc1C	10.1021/jm00144a009
	CHEMBL282183	98865	6	None	-	1	Rat	5.6	pKd	=	5.6	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	209	4	1	3	1.9	COc1cc(OC)c(CC(C)N)cc1C	10.1021/jm00144a009
	34677	101749	79	None	-	1	Rat	5.6	pKd	=	5.6	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	147	0	1	1	1.5	NC1CCc2ccccc2C1	10.1021/jm00343a013
	CHEMBL30294	101749	79	None	-	1	Rat	5.6	pKd	=	5.6	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	147	0	1	1	1.5	NC1CCc2ccccc2C1	10.1021/jm00343a013
	141047	98947	15	None	1	3	Rat	5.6	pKd	=	5.6	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1ccc(CC(C)N)c(OC)c1	10.1021/jm00144a009
	CHEMBL282734	98947	15	None	1	3	Rat	5.6	pKd	=	5.6	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1ccc(CC(C)N)c(OC)c1	10.1021/jm00144a009
	31016	101817	12	None	-11	5	Rat	5.6	pKd	=	5.6	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	225	5	1	4	1.6	COc1cc(CC(C)N)cc(OC)c1OC	10.1021/jm00144a009
	CHEMBL30336	101817	12	None	-11	5	Rat	5.6	pKd	=	5.6	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	225	5	1	4	1.6	COc1cc(CC(C)N)cc(OC)c1OC	10.1021/jm00144a009
	15011362	52366	20	None	-	1	Rat	5.6	pKd	=	5.6	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	161	2	1	1	2.1	NCCC1CCc2ccccc21	10.1021/jm00343a013
	CHEMBL159346	52366	20	None	-	1	Rat	5.6	pKd	=	5.6	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	161	2	1	1	2.1	NCCC1CCc2ccccc21	10.1021/jm00343a013
	744368	164377	17	None	-	1	Rat	6.6	pKd	=	6.6	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	190	3	0	2	1.6	CN(C)CCN1CCc2ccccc21	10.1021/jm00367a008
	CHEMBL422471	164377	17	None	-	1	Rat	6.6	pKd	=	6.6	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	190	3	0	2	1.6	CN(C)CCN1CCc2ccccc21	10.1021/jm00367a008
	159755	56800	57	None	-	1	Rat	5.5	pKd	=	5.5	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	165	3	1	2	1.6	COc1ccccc1CC(C)N	10.1021/jm00144a009
	CHEMBL16451	56800	57	None	-	1	Rat	5.5	pKd	=	5.5	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	165	3	1	2	1.6	COc1ccccc1CC(C)N	10.1021/jm00144a009
	91255	98654	9	None	-	1	Rat	5.5	pKd	=	5.5	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1cccc(CC(C)N)c1OC	10.1021/jm00144a009
	CHEMBL280855	98654	9	None	-	1	Rat	5.5	pKd	=	5.5	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1cccc(CC(C)N)c1OC	10.1021/jm00144a009
	189	3436	31	None	2	17	Rat	8.5	pKd	=	8.5	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm960571v
	5163	3436	31	None	2	17	Rat	8.5	pKd	=	8.5	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm960571v
	CHEMBL297784	3436	31	None	2	17	Rat	8.5	pKd	=	8.5	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm960571v
	189	3436	31	None	2	17	Rat	8.5	pKd	=	8.5	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm00014a004
	5163	3436	31	None	2	17	Rat	8.5	pKd	=	8.5	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm00014a004
	CHEMBL297784	3436	31	None	2	17	Rat	8.5	pKd	=	8.5	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm00014a004
	10683987	120765	1	None	3	2	Rat	7.5	pKd	=	7.5	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	278	1	2	2	3.2	O=C(Nc1cccnc1)N1CCc2cc3[nH]ccc3cc21	10.1021/jm960571v
	CHEMBL357870	120765	1	None	3	2	Rat	7.5	pKd	=	7.5	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	278	1	2	2	3.2	O=C(Nc1cccnc1)N1CCc2cc3[nH]ccc3cc21	10.1021/jm960571v
	1614	201960	22	None	-2	9	Rat	6.5	pKd	=	6.5	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	179	2	1	3	1.3	CC(N)Cc1ccc2c(c1)OCO2	10.1021/jm00144a009
	CHEMBL6731	201960	22	None	-2	9	Rat	6.5	pKd	=	6.5	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	179	2	1	3	1.3	CC(N)Cc1ccc2c(c1)OCO2	10.1021/jm00144a009
	8423	98236	26	None	-	1	Rat	5.5	pKd	=	5.5	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1ccc(CC(C)N)cc1OC	10.1021/jm00144a009
	CHEMBL277540	98236	26	None	-	1	Rat	5.5	pKd	=	5.5	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1ccc(CC(C)N)cc1OC	10.1021/jm00144a009
	126769	204323	35	None	-1	5	Rat	7.4	pKd	=	7.4	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	266	2	2	3	3.2	Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc21	10.1021/jm00014a004
	CHEMBL536255	204323	35	None	-1	5	Rat	7.4	pKd	=	7.4	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	266	2	2	3	3.2	Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc21	10.1021/jm00014a004
	CHEMBL85194	204323	35	None	-1	5	Rat	7.4	pKd	=	7.4	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	266	2	2	3	3.2	Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc21	10.1021/jm00014a004
	12451869	54898	5	None	-	1	Rat	5.4	pKd	=	5.4	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	175	3	1	1	2.3	CNCCC1CCc2ccccc21	10.1021/jm00343a013
	CHEMBL161751	54898	5	None	-	1	Rat	5.4	pKd	=	5.4	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	175	3	1	1	2.3	CNCCC1CCc2ccccc21	10.1021/jm00343a013
	155	719	20	None	-10	12	Rat	7.4	pKd	=	7.4	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	10.1021/jm00144a009
	163	719	20	None	-10	12	Rat	7.4	pKd	=	7.4	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	10.1021/jm00144a009
	62065	719	20	None	-10	12	Rat	7.4	pKd	=	7.4	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	10.1021/jm00144a009
	CHEMBL6607	719	20	None	-10	12	Rat	7.4	pKd	=	7.4	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	10.1021/jm00144a009
	DB01484	719	20	None	-10	12	Rat	7.4	pKd	=	7.4	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	10.1021/jm00144a009
	44375004	52726	1	None	-	1	Rat	5.3	pKd	=	5.3	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	189	3	0	1	2.7	CN(C)CCC1CCc2ccccc21	10.1021/jm00343a013
	CHEMBL159689	52726	1	None	-	1	Rat	5.3	pKd	=	5.3	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	189	3	0	1	2.7	CN(C)CCC1CCc2ccccc21	10.1021/jm00343a013
	44359477	115934	0	None	-	1	Rat	7.3	pKd	=	7.3	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	201	3	0	1	4.0	Cc1cccc2ccn(CCC(C)C)c12	10.1021/jm00367a008
	CHEMBL336042	115934	0	None	-	1	Rat	7.3	pKd	=	7.3	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	201	3	0	1	4.0	Cc1cccc2ccn(CCC(C)C)c12	10.1021/jm00367a008
	77042	187773	52	None	-	1	Rat	5.3	pKd	=	5.3	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	177	4	0	2	1.8	CN(C)CCC(=O)c1ccccc1	10.1021/jm00343a013
	CHEMBL50115	187773	52	None	-	1	Rat	5.3	pKd	=	5.3	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	177	4	0	2	1.8	CN(C)CCC(=O)c1ccccc1	10.1021/jm00343a013
	31015	117911	12	None	-	1	Rat	6.3	pKd	=	6.3	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	225	5	1	4	1.6	COc1cc(OC)c(CC(C)N)c(OC)c1	10.1021/jm00144a009
	CHEMBL34108	117911	12	None	-	1	Rat	6.3	pKd	=	6.3	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	225	5	1	4	1.6	COc1cc(OC)c(CC(C)N)c(OC)c1	10.1021/jm00144a009
	10335310	204285	0	None	75	2	Rat	7.3	pKd	=	7.3	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	306	1	1	3	3.6	Cn1ccc2cc3c(cc21)CCCN3C(=O)Nc1cccnc1	10.1021/jm00014a004
	CHEMBL84888	204285	0	None	75	2	Rat	7.3	pKd	=	7.3	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	306	1	1	3	3.6	Cn1ccc2cc3c(cc21)CCCN3C(=O)Nc1cccnc1	10.1021/jm00014a004
	33984	29428	37	None	-	1	Rat	6.3	pKd	=	6.3	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	192	5	0	2	2.1	CCN(CCN(C)C)c1ccccc1	10.1021/jm00367a008
	CHEMBL138604	29428	37	None	-	1	Rat	6.3	pKd	=	6.3	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	192	5	0	2	2.1	CCN(CCN(C)C)c1ccccc1	10.1021/jm00367a008
	1150	3817	116	None	-8	24	Rat	6.3	pKd	=	6.3	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1021/jm00343a013
	125	3817	116	None	-8	24	Rat	6.3	pKd	=	6.3	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1021/jm00343a013
	CHEMBL6640	3817	116	None	-8	24	Rat	6.3	pKd	=	6.3	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1021/jm00343a013
	DB08653	3817	116	None	-8	24	Rat	6.3	pKd	=	6.3	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1021/jm00343a013
	3007	155144	25	None	-1	6	Rat	5.3	pKd	=	5.3	Binding	Affinity against serotonergic receptor in the isolated rat stomach fundusAffinity against serotonergic receptor in the isolated rat stomach fundus	ChEMBL	135	2	1	1	1.6	CC(N)Cc1ccccc1	10.1021/jm00144a009
	CHEMBL405	155144	25	None	-1	6	Rat	5.3	pKd	=	5.3	Binding	Affinity against serotonergic receptor in the isolated rat stomach fundusAffinity against serotonergic receptor in the isolated rat stomach fundus	ChEMBL	135	2	1	1	1.6	CC(N)Cc1ccccc1	10.1021/jm00144a009
	127035062	135928	0	None	-4	19	Human	6.3	pKd	=	6.3	Binding	Non-competitive antagonist activity at human recombinant 5-HT2B receptor stably expressed in HEK cell membrane by schild plot methodNon-competitive antagonist activity at human recombinant 5-HT2B receptor stably expressed in HEK cell membrane by schild plot method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3735756	135928	0	None	-4	19	Human	6.3	pKd	=	6.3	Binding	Non-competitive antagonist activity at human recombinant 5-HT2B receptor stably expressed in HEK cell membrane by schild plot methodNon-competitive antagonist activity at human recombinant 5-HT2B receptor stably expressed in HEK cell membrane by schild plot method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	10591799	39710	0	None	1	2	Rat	8.2	pKd	=	8.2	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	320	2	1	3	4.2	CC(C)n1ccc2cc3c(cc21)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
	CHEMBL147820	39710	0	None	1	2	Rat	8.2	pKd	=	8.2	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	320	2	1	3	4.2	CC(C)n1ccc2cc3c(cc21)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
	44363813	40319	0	None	19	2	Rat	8.2	pKd	=	8.2	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	305	1	1	2	4.1	Cc1cn(C)c2cc3c(cc12)N(C(=O)Nc1ccccc1)CC3	10.1021/jm960571v
	CHEMBL148347	40319	0	None	19	2	Rat	8.2	pKd	=	8.2	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	305	1	1	2	4.1	Cc1cn(C)c2cc3c(cc12)N(C(=O)Nc1ccccc1)CC3	10.1021/jm960571v
	10335309	204326	0	None	-	1	Rat	7.2	pKd	=	7.2	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	306	1	1	3	3.6	Cn1ccc2c3c(ccc21)N(C(=O)Nc1cccnc1)CCC3	10.1021/jm00014a004
	CHEMBL85247	204326	0	None	-	1	Rat	7.2	pKd	=	7.2	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	306	1	1	3	3.6	Cn1ccc2c3c(ccc21)N(C(=O)Nc1cccnc1)CCC3	10.1021/jm00014a004
	31721	98366	37	None	-	1	Rat	5.2	pKd	=	5.2	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	165	3	1	2	1.6	COc1ccc(CC(C)N)cc1	10.1021/jm00144a009
	CHEMBL278663	98366	37	None	-	1	Rat	5.2	pKd	=	5.2	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	165	3	1	2	1.6	COc1ccc(CC(C)N)cc1	10.1021/jm00144a009
	10495940	78448	0	None	1	2	Rat	8.1	pKd	=	8.1	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	320	3	1	3	4.0	CCCn1ccc2cc3c(cc21)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
	CHEMBL2112859	78448	0	None	1	2	Rat	8.1	pKd	=	8.1	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	320	3	1	3	4.0	CCCn1ccc2cc3c(cc21)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
	44359524	28656	1	None	-	1	Rat	7.1	pKd	=	7.1	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	201	3	0	1	4.0	Cc1cccc2c1ccn2CCC(C)C	10.1021/jm00367a008
	CHEMBL137932	28656	1	None	-	1	Rat	7.1	pKd	=	7.1	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	201	3	0	1	4.0	Cc1cccc2c1ccn2CCC(C)C	10.1021/jm00367a008
	164	1432	17	None	-3	9	Rat	7.1	pKd	=	7.1	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	209	4	1	3	1.9	COc1cc(C)c(cc1CC(N)C)OC	10.1021/jm00144a009
	85875	1432	17	None	-3	9	Rat	7.1	pKd	=	7.1	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	209	4	1	3	1.9	COc1cc(C)c(cc1CC(N)C)OC	10.1021/jm00144a009
	CHEMBL8600	1432	17	None	-3	9	Rat	7.1	pKd	=	7.1	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	209	4	1	3	1.9	COc1cc(C)c(cc1CC(N)C)OC	10.1021/jm00144a009
	DB01528	1432	17	None	-3	9	Rat	7.1	pKd	=	7.1	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	209	4	1	3	1.9	COc1cc(C)c(cc1CC(N)C)OC	10.1021/jm00144a009
	141048	102396	6	None	-	1	Rat	5.1	pKd	=	5.1	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1cccc(OC)c1CC(C)N	10.1021/jm00144a009
	CHEMBL30577	102396	6	None	-	1	Rat	5.1	pKd	=	5.1	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1cccc(OC)c1CC(C)N	10.1021/jm00144a009
	25187	99835	25	None	-	1	Rat	5.1	pKd	=	5.1	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	163	4	0	1	2.2	CN(C)CCCc1ccccc1	10.1021/jm00343a013
	CHEMBL289199	99835	25	None	-	1	Rat	5.1	pKd	=	5.1	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	163	4	0	1	2.2	CN(C)CCCc1ccccc1	10.1021/jm00343a013
	44359556	118923	0	None	-	1	Rat	7.1	pKd	=	7.1	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	220	4	1	3	2.2	COc1ccc2c(c1)NCC2CCN(C)C	10.1021/jm00367a008
	CHEMBL344878	118923	0	None	-	1	Rat	7.1	pKd	=	7.1	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	220	4	1	3	2.2	COc1ccc2c(c1)NCC2CCN(C)C	10.1021/jm00367a008
	145	140	48	None	-16	29	Rat	7.1	pKd	=	7.1	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00343a013
	1832	140	48	None	-16	29	Rat	7.1	pKd	=	7.1	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00343a013
	CHEMBL7257	140	48	None	-16	29	Rat	7.1	pKd	=	7.1	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00343a013
	DB14010	140	48	None	-16	29	Rat	7.1	pKd	=	7.1	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00343a013
	31012	102643	15	None	-	1	Rat	5.1	pKd	=	5.1	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	225	5	1	4	1.6	COc1ccc(CC(C)N)c(OC)c1OC	10.1021/jm00144a009
	CHEMBL30777	102643	15	None	-	1	Rat	5.1	pKd	=	5.1	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	225	5	1	4	1.6	COc1ccc(CC(C)N)c(OC)c1OC	10.1021/jm00144a009
	81206	29437	32	None	-	1	Rat	6.0	pKd	=	6.0	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	164	4	1	2	1.7	CN(C)CCNc1ccccc1	10.1021/jm00367a008
	CHEMBL138614	29437	32	None	-	1	Rat	6.0	pKd	=	6.0	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	164	4	1	2	1.7	CN(C)CCNc1ccccc1	10.1021/jm00367a008
	81206	29437	32	None	-	1	Rat	6.0	pKd	=	6.0	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	164	4	1	2	1.7	CN(C)CCNc1ccccc1	10.1021/jm00343a013
	CHEMBL138614	29437	32	None	-	1	Rat	6.0	pKd	=	6.0	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	164	4	1	2	1.7	CN(C)CCNc1ccccc1	10.1021/jm00343a013
	11666595	120021	0	None	301	2	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1c(Cl)cccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310115	120021	0	None	301	2	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1c(Cl)cccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545467	120021	0	None	301	2	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1c(Cl)cccc1-2	10.1016/j.bmc.2014.05.027
	9839057	41153	3	None	-9	3	Human	9.7	pKi	=	9.7	Binding	Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.	ChEMBL	293	2	1	3	3.8	CC(N)Cc1c2ccoc2c(Br)c2ccoc12	10.1021/jm9803525
	CHEMBL149024	41153	3	None	-9	3	Human	9.7	pKi	=	9.7	Binding	Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.	ChEMBL	293	2	1	3	3.8	CC(N)Cc1c2ccoc2c(Br)c2ccoc12	10.1021/jm9803525
	9953185	205885	2	None	123	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity to human 5-HT2B assessed as inhibition constantBinding affinity to human 5-HT2B assessed as inhibition constant	ChEMBL	370	4	2	3	4.6	COc1ccc(CC2NCCc3c2[nH]c2ccc(C)cc32)c(Cl)c1OC	10.1021/acs.jmedchem.2c00633
	CHEMBL95121	205885	2	None	123	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity to human 5-HT2B assessed as inhibition constantBinding affinity to human 5-HT2B assessed as inhibition constant	ChEMBL	370	4	2	3	4.6	COc1ccc(CC2NCCc3c2[nH]c2ccc(C)cc32)c(Cl)c1OC	10.1021/acs.jmedchem.2c00633
	133	2460	48	None	-2	42	Human	9.6	pKi	=	9.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	1723	2460	48	None	-2	42	Human	9.6	pKi	=	9.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	28693	2460	48	None	-2	42	Human	9.6	pKi	=	9.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	CHEMBL19215	2460	48	None	-2	42	Human	9.6	pKi	=	9.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	DB13520	2460	48	None	-2	42	Human	9.6	pKi	=	9.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	188	3339	73	None	-1	6	Human	9.5	pKi	=	9.5	Binding	Binding affinity to 5-HT2B (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2B (unknown origin) assessed as inhibition constant	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1021/acs.jmedchem.2c00633
	196968	3339	73	None	-1	6	Human	9.5	pKi	=	9.5	Binding	Binding affinity to 5-HT2B (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2B (unknown origin) assessed as inhibition constant	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1021/acs.jmedchem.2c00633
	CHEMBL473186	3339	73	None	-1	6	Human	9.5	pKi	=	9.5	Binding	Binding affinity to 5-HT2B (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2B (unknown origin) assessed as inhibition constant	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1021/acs.jmedchem.2c00633
	70772974	190893	6	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human 5-HT2B assessed as inhibition constant in microplate beta scintillation counter analysisBinding affinity to human 5-HT2B assessed as inhibition constant in microplate beta scintillation counter analysis	ChEMBL	369	3	2	3	3.8	Cc1c(C(=O)N2CCC(c3ncc[nH]3)CC2)n[nH]c1-c1ccc(Cl)cc1	10.1021/acs.jmedchem.2c00633
	CHEMBL5193649	190893	6	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human 5-HT2B assessed as inhibition constant in microplate beta scintillation counter analysisBinding affinity to human 5-HT2B assessed as inhibition constant in microplate beta scintillation counter analysis	ChEMBL	369	3	2	3	3.8	Cc1c(C(=O)N2CCC(c3ncc[nH]3)CC2)n[nH]c1-c1ccc(Cl)cc1	10.1021/acs.jmedchem.2c00633
	134	2478	19	None	-2	67	Human	9.5	pKi	=	9.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	1775	2478	19	None	-2	67	Human	9.5	pKi	=	9.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	9681	2478	19	None	-2	67	Human	9.5	pKi	=	9.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	CHEMBL1065	2478	19	None	-2	67	Human	9.5	pKi	=	9.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	DB00247	2478	19	None	-2	67	Human	9.5	pKi	=	9.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	242	467	117	None	-1	51	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
	34	467	117	None	-1	51	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
	60795	467	117	None	-1	51	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
	CHEMBL1112	467	117	None	-1	51	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
	DB01238	467	117	None	-1	51	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
	11393666	192384	0	None	1	19	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
	CHEMBL5201983	192384	0	None	1	19	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
	CHEMBL5222597	192384	0	None	1	19	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
	11978813	713	72	None	-2	23	Human	9.4	pKi	=	9.4	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
	5014	713	72	None	-2	23	Human	9.4	pKi	=	9.4	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
	7672	713	72	None	-2	23	Human	9.4	pKi	=	9.4	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
	CHEMBL2105760	713	72	None	-2	23	Human	9.4	pKi	=	9.4	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
	DB09128	713	72	None	-2	23	Human	9.4	pKi	=	9.4	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
	11465618	101926	18	None	-1	19	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
	CHEMBL3039528	101926	18	None	-1	19	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
	CHEMBL5191141	101926	18	None	-1	19	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
	23151734	103481	0	None	467	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	265	1	2	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(=O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3092758	103481	0	None	467	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	265	1	2	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(=O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	11687730	120074	0	None	9	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	277	1	2	1	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343668	120074	0	None	9	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	277	1	2	1	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3545816	120074	0	None	9	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	277	1	2	1	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	71528206	86543	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	314	3	0	4	2.8	COC(OC)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	CHEMBL2323581	86543	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	314	3	0	4	2.8	COC(OC)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	56597938	3877	1	None	2	9	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm300603y
	7651	3877	1	None	2	9	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm300603y
	CHEMBL2165126	3877	1	None	2	9	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm300603y
	56597090	81571	0	None	-1	5	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	434	7	0	4	6.6	Clc1cccc(C2CCN(CCCCOc3ccc4scnc4c3)CC2)c1Cl	10.1021/jm300603y
	CHEMBL2165137	81571	0	None	-1	5	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	434	7	0	4	6.6	Clc1cccc(C2CCN(CCCCOc3ccc4scnc4c3)CC2)c1Cl	10.1021/jm300603y
	56597938	3877	1	None	2	9	Human	9.2	pKi	=	9.2	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
	7651	3877	1	None	2	9	Human	9.2	pKi	=	9.2	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
	CHEMBL2165126	3877	1	None	2	9	Human	9.2	pKi	=	9.2	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
	118706290	120022	0	None	128	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1C(O)c1cc(C(=O)N=C(N)N)ccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310116	120022	0	None	128	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1C(O)c1cc(C(=O)N=C(N)N)ccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545468	120022	0	None	128	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1C(O)c1cc(C(=O)N=C(N)N)ccc1-2	10.1016/j.bmc.2014.05.027
	118706734	120015	0	None	3	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	309	2	3	2	1.9	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
	CHEMBL3310714	120015	0	None	3	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	309	2	3	2	1.9	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
	CHEMBL3545444	120015	0	None	3	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	309	2	3	2	1.9	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
	150	2473	18	None	1	15	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	1764	2473	18	None	1	15	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	8226	2473	18	None	1	15	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	CHEMBL1201356	2473	18	None	1	15	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	DB00353	2473	18	None	1	15	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	118706282	120019	0	None	17	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	CHEMBL3310111	120019	0	None	17	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	CHEMBL3545465	120019	0	None	17	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	118706299	120026	0	None	64	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	269	1	3	2	2.3	N=C(N)NC(=O)c1ccc2c(c1)C(F)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310121	120026	0	None	64	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	269	1	3	2	2.3	N=C(N)NC(=O)c1ccc2c(c1)C(F)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545472	120026	0	None	64	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	269	1	3	2	2.3	N=C(N)NC(=O)c1ccc2c(c1)C(F)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	118706284	120013	0	None	31	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	285	1	3	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(F)c1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310112	120013	0	None	31	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	285	1	3	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(F)c1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545440	120013	0	None	31	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	285	1	3	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(F)c1-2	10.1016/j.bmc.2014.05.027
	150	2473	18	None	1	15	Human	9.0	pKi	=	9.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	1764	2473	18	None	1	15	Human	9.0	pKi	=	9.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	8226	2473	18	None	1	15	Human	9.0	pKi	=	9.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	CHEMBL1201356	2473	18	None	1	15	Human	9.0	pKi	=	9.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	DB00353	2473	18	None	1	15	Human	9.0	pKi	=	9.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	71528205	86542	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	368	5	1	4	2.2	CN(C)CCCNC(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	CHEMBL2323580	86542	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	368	5	1	4	2.2	CN(C)CCCNC(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	71528204	86541	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	439	6	1	5	2.6	CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	CHEMBL2323579	86541	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	439	6	1	5	2.6	CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	11358099	179825	0	None	3	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	285	3	1	4	2.8	COc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4752099	179825	0	None	3	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	285	3	1	4	2.8	COc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	11460460	181780	0	None	-1	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	289	2	1	3	3.5	CC(C)n1nc2c(c1-c1ccc(Cl)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4784845	181780	0	None	-1	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	289	2	1	3	3.5	CC(C)n1nc2c(c1-c1ccc(Cl)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	9954003	71356	18	None	-1	9	Human	9.0	pKi	=	9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	422	5	2	4	3.8	C[C@H]1Oc2c(cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)NC1=O	10.1021/jm070516u
	CHEMBL196514	71356	18	None	-1	9	Human	9.0	pKi	=	9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	422	5	2	4	3.8	C[C@H]1Oc2c(cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)NC1=O	10.1021/jm070516u
	16062782	97384	0	None	2	3	Human	9.0	pKi	=	9	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	307	2	1	3	3.8	Cc1ccc(-c2nc(C3CCCC3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL272082	97384	0	None	2	3	Human	9.0	pKi	=	9	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	307	2	1	3	3.8	Cc1ccc(-c2nc(C3CCCC3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	59757163	105861	0	None	218	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1cccc2c1Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3092760	105861	0	None	218	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1cccc2c1Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3139189	105861	0	None	218	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1cccc2c1Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
	118706732	120016	0	None	3	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	295	1	3	2	1.6	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
	CHEMBL3310713	120016	0	None	3	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	295	1	3	2	1.6	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
	CHEMBL3545445	120016	0	None	3	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	295	1	3	2	1.6	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
	56593482	3878	1	None	1	9	Human	9.0	pKi	=	9.0	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	462	7	1	5	4.6	O=C1CCc2c(N1)nc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
	7650	3878	1	None	1	9	Human	9.0	pKi	=	9.0	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	462	7	1	5	4.6	O=C1CCc2c(N1)nc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
	CHEMBL2165119	3878	1	None	1	9	Human	9.0	pKi	=	9.0	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	462	7	1	5	4.6	O=C1CCc2c(N1)nc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
	10568771	102316	2	None	-5	5	Human	8.9	pKi	=	8.9	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligand	ChEMBL	297	2	1	3	2.2	C[C@@H](N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm980076u
	CHEMBL305275	102316	2	None	-5	5	Human	8.9	pKi	=	8.9	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligand	ChEMBL	297	2	1	3	2.2	C[C@@H](N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm980076u
	CHEMBL6710	102316	2	None	-5	5	Human	8.9	pKi	=	8.9	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligand	ChEMBL	297	2	1	3	2.2	C[C@@H](N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm980076u
	242	467	117	None	-1	51	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
	34	467	117	None	-1	51	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
	60795	467	117	None	-1	51	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
	CHEMBL1112	467	117	None	-1	51	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
	DB01238	467	117	None	-1	51	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
	11658860	2312	47	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Agonist activity at 5-HT2B receptor (unknown origin)Agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2012.10.091
	2941	2312	47	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Agonist activity at 5-HT2B receptor (unknown origin)Agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2012.10.091
	4374	2312	47	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Agonist activity at 5-HT2B receptor (unknown origin)Agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2012.10.091
	CHEMBL360328	2312	47	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Agonist activity at 5-HT2B receptor (unknown origin)Agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2012.10.091
	DB04871	2312	47	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Agonist activity at 5-HT2B receptor (unknown origin)Agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2012.10.091
	37	766	56	None	1	17	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1021/ml3003814
	460	766	56	None	1	17	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1021/ml3003814
	54746	766	56	None	1	17	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1021/ml3003814
	CHEMBL1201087	766	56	None	1	17	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1021/ml3003814
	DB00248	766	56	None	1	17	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1021/ml3003814
	242	467	117	None	-1	51	Human	8.9	pKi	=	8.9	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
	34	467	117	None	-1	51	Human	8.9	pKi	=	8.9	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
	60795	467	117	None	-1	51	Human	8.9	pKi	=	8.9	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
	CHEMBL1112	467	117	None	-1	51	Human	8.9	pKi	=	8.9	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
	DB01238	467	117	None	-1	51	Human	8.9	pKi	=	8.9	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
	118706278	120012	0	None	26	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(Cl)c1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310109	120012	0	None	26	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(Cl)c1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545439	120012	0	None	26	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(Cl)c1-2	10.1016/j.bmc.2014.05.027
	2865	4079	67	None	-12	53	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
	59	4079	67	None	-12	53	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
	60854	4079	67	None	-12	53	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
	CHEMBL708	4079	67	None	-12	53	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
	DB00246	4079	67	None	-12	53	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
	9888211	21216	9	None	-1	10	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	417	6	1	3	4.5	O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1	10.1021/jm070516u
	CHEMBL131495	21216	9	None	-1	10	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	417	6	1	3	4.5	O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1	10.1021/jm070516u
	10568771	102316	2	None	-5	5	Human	8.8	pKi	=	8.8	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligand	ChEMBL	297	2	1	3	2.2	C[C@@H](N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm980076u
	CHEMBL305275	102316	2	None	-5	5	Human	8.8	pKi	=	8.8	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligand	ChEMBL	297	2	1	3	2.2	C[C@@H](N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm980076u
	CHEMBL6710	102316	2	None	-5	5	Human	8.8	pKi	=	8.8	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligand	ChEMBL	297	2	1	3	2.2	C[C@@H](N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm980076u
	10017554	4275	25	None	-1	4	Human	8.8	pKi	=	8.8	Binding	Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.	ChEMBL	297	2	1	3	2.2	CC(N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm9803525
	CHEMBL101008	4275	25	None	-1	4	Human	8.8	pKi	=	8.8	Binding	Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.	ChEMBL	297	2	1	3	2.2	CC(N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm9803525
	11957541	1430	38	None	-1	15	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
	1229	1430	38	None	-1	15	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
	147	1430	38	None	-1	15	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
	170617	1430	38	None	-1	15	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
	CHEMBL6616	1430	38	None	-1	15	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
	118706285	112389	0	None	2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	295	2	3	2	1.7	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	CHEMBL3310113	112389	0	None	2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	295	2	3	2	1.7	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	135399866	71711	2	None	-1	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	209	2	2	4	1.2	C[C@H](N)Cn1ncc2ccc(O)c(F)c21	10.1021/jm050663x
	CHEMBL197653	71711	2	None	-1	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	209	2	2	4	1.2	C[C@H](N)Cn1ncc2ccc(O)c(F)c21	10.1021/jm050663x
	118464429	166564	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	383	1	3	5	2.6	NC1=NC2(CCCCC2)NC(Nc2cccc(I)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL4290245	166564	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	383	1	3	5	2.6	NC1=NC2(CCCCC2)NC(Nc2cccc(I)c2)=N1	10.1021/acsmedchemlett.8b00300
	127048333	140149	0	None	38	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	465	12	0	5	5.3	COc1ccc(CCN(CCCc2ccccc2F)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3815112	140149	0	None	38	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	465	12	0	5	5.3	COc1ccc(CCN(CCCc2ccccc2F)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	118706280	120018	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cc(Cl)ccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310110	120018	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cc(Cl)ccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545464	120018	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cc(Cl)ccc1-2	10.1016/j.bmc.2014.05.027
	118717220	120069	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	305	1	2	1	2.9	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343669	120069	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	305	1	2	1	2.9	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3545811	120069	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	305	1	2	1	2.9	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	72734860	103480	0	None	6	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3092753	103480	0	None	6	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
	11277147	105860	0	None	9	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3092759	105860	0	None	9	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3139188	105860	0	None	9	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	11277147	105860	0	None	9	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3092759	105860	0	None	9	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3139188	105860	0	None	9	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	134	2478	19	None	-2	67	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.ejmech.2019.111736
	1775	2478	19	None	-2	67	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.ejmech.2019.111736
	9681	2478	19	None	-2	67	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.ejmech.2019.111736
	CHEMBL1065	2478	19	None	-2	67	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.ejmech.2019.111736
	DB00247	2478	19	None	-2	67	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.ejmech.2019.111736
	206	2457	10	None	-1	24	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/S0960-894X(96)00503-3
	68848	2457	10	None	-1	24	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/S0960-894X(96)00503-3
	CHEMBL12314	2457	10	None	-1	24	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/S0960-894X(96)00503-3
	192	3446	46	None	-10	3	Human	8.0	pKi	=	8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	431	3	1	3	5.5	COc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cc(F)cc(c1)c1cccnc1	10.1021/jm990388c
	443390	3446	46	None	-10	3	Human	8.0	pKi	=	8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	431	3	1	3	5.5	COc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cc(F)cc(c1)c1cccnc1	10.1021/jm990388c
	CHEMBL14276	3446	46	None	-10	3	Human	8.0	pKi	=	8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	431	3	1	3	5.5	COc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cc(F)cc(c1)c1cccnc1	10.1021/jm990388c
	10573762	98327	0	None	1	3	Human	8.0	pKi	=	8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	413	3	1	3	5.4	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(-c3cccnc3)cc1)CC2	10.1021/jm990388c
	CHEMBL278267	98327	0	None	1	3	Human	8.0	pKi	=	8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	413	3	1	3	5.4	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(-c3cccnc3)cc1)CC2	10.1021/jm990388c
	10670813	162041	0	None	-15	3	Human	8.0	pKi	=	8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	441	4	1	3	5.9	CCc1cc(NC(=O)N2CCc3cc(OC)c(C(F)(F)F)cc32)cc(-c2cccnc2)c1	10.1021/jm990388c
	CHEMBL416896	162041	0	None	-15	3	Human	8.0	pKi	=	8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	441	4	1	3	5.9	CCc1cc(NC(=O)N2CCc3cc(OC)c(C(F)(F)F)cc32)cc(-c2cccnc2)c1	10.1021/jm990388c
	44397929	66845	0	None	-6	3	Human	8.0	pKi	=	8	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	222	0	1	2	2.0	Cc1c(Cl)ccc2c1N1CCNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
	CHEMBL187739	66845	0	None	-6	3	Human	8.0	pKi	=	8	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	222	0	1	2	2.0	Cc1c(Cl)ccc2c1N1CCNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
	10808965	99867	0	None	-3	3	Human	8.0	pKi	=	8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	367	3	1	3	4.8	CCSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
	CHEMBL289436	99867	0	None	-3	3	Human	8.0	pKi	=	8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	367	3	1	3	4.8	CCSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
	46230098	197649	0	None	-3	3	Human	8.0	pKi	=	8	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	231	0	2	3	0.9	Cc1cccc2c1C(=O)NC1CCNCCN21	10.1016/j.bmcl.2009.12.014
	CHEMBL590580	197649	0	None	-3	3	Human	8.0	pKi	=	8	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	231	0	2	3	0.9	Cc1cccc2c1C(=O)NC1CCNCCN21	10.1016/j.bmcl.2009.12.014
	18931422	205660	0	None	-50	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	435	8	2	5	3.4	COc1ccc(-c2ccccc2)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
	CHEMBL93862	205660	0	None	-50	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	435	8	2	5	3.4	COc1ccc(-c2ccccc2)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
	10740494	34913	0	None	-12	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	414	3	1	4	4.8	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3cccnc3)c1)CC2	10.1021/jm990388c
	CHEMBL14345	34913	0	None	-12	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	414	3	1	4	4.8	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3cccnc3)c1)CC2	10.1021/jm990388c
	10764263	40645	0	None	-15	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	414	3	1	4	4.8	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3ccncc3)c1)CC2	10.1021/jm990388c
	CHEMBL14863	40645	0	None	-15	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	414	3	1	4	4.8	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3ccncc3)c1)CC2	10.1021/jm990388c
	10740495	98176	0	None	-1	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	414	3	1	4	4.8	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(-c3cccnc3)nc1)CC2	10.1021/jm990388c
	CHEMBL277111	98176	0	None	-1	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	414	3	1	4	4.8	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(-c3cccnc3)nc1)CC2	10.1021/jm990388c
	122178705	120857	0	None	2	5	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	411	7	0	5	5.0	CCCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL3581250	120857	0	None	2	5	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	411	7	0	5	5.0	CCCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	59395105	105859	1	None	4	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	252	1	3	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)[nH]c1ccccc12	10.1016/j.bmc.2013.10.010
	CHEMBL3092755	105859	1	None	4	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	252	1	3	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)[nH]c1ccccc12	10.1016/j.bmc.2013.10.010
	CHEMBL3139187	105859	1	None	4	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	252	1	3	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)[nH]c1ccccc12	10.1016/j.bmc.2013.10.010
	118729272	120198	0	None	3	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	5.0	CN(C)[C@@H]1Cc2ccccc2[C@@H](C2CCCCCCC2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402680	120198	0	None	3	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	5.0	CN(C)[C@@H]1Cc2ccccc2[C@@H](C2CCCCCCC2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547158	120198	0	None	3	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	5.0	CN(C)[C@@H]1Cc2ccccc2[C@@H](C2CCCCCCC2)C1	10.1016/j.bmc.2015.01.060
	44214724	193316	0	None	-19	3	Human	8.0	pKi	=	8	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	429	4	1	5	4.4	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3cnccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL54707	193316	0	None	-19	3	Human	8.0	pKi	=	8	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	429	4	1	5	4.4	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3cnccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	5	139	66	None	-13	54	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00726
	5202	139	66	None	-13	54	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00726
	CHEMBL39	139	66	None	-13	54	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00726
	DB08839	139	66	None	-13	54	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00726
	24841480	183317	0	None	-50	20	Human	7.0	pKi	=	7	Binding	Antagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
	CHEMBL481153	183317	0	None	-50	20	Human	7.0	pKi	=	7	Binding	Antagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
	193	3450	38	None	-707	4	Human	7.0	pKi	=	7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1021/jm990388c
	3644637	3450	38	None	-707	4	Human	7.0	pKi	=	7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1021/jm990388c
	CHEMBL14563	3450	38	None	-707	4	Human	7.0	pKi	=	7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1021/jm990388c
	194	3451	25	None	-100	3	Human	7.0	pKi	=	7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10.1021/jm990388c
	443391	3451	25	None	-100	3	Human	7.0	pKi	=	7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10.1021/jm990388c
	CHEMBL14460	3451	25	None	-100	3	Human	7.0	pKi	=	7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10.1021/jm990388c
	193	3450	38	None	-707	4	Human	7.0	pKi	=	7	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1016/j.bmcl.2005.08.004
	3644637	3450	38	None	-707	4	Human	7.0	pKi	=	7	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1016/j.bmcl.2005.08.004
	CHEMBL14563	3450	38	None	-707	4	Human	7.0	pKi	=	7	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1016/j.bmcl.2005.08.004
	194	3451	25	None	-100	3	Human	7.0	pKi	=	7	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10.1016/j.bmcl.2005.08.004
	443391	3451	25	None	-100	3	Human	7.0	pKi	=	7	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10.1016/j.bmcl.2005.08.004
	CHEMBL14460	3451	25	None	-100	3	Human	7.0	pKi	=	7	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10.1016/j.bmcl.2005.08.004
	193	3450	38	None	-707	4	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1016/s0960-894x(00)00364-4
	3644637	3450	38	None	-707	4	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1016/s0960-894x(00)00364-4
	CHEMBL14563	3450	38	None	-707	4	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1016/s0960-894x(00)00364-4
	194	3451	25	None	-100	3	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10.1016/s0960-894x(00)00364-4
	443391	3451	25	None	-100	3	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10.1016/s0960-894x(00)00364-4
	CHEMBL14460	3451	25	None	-100	3	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10.1016/s0960-894x(00)00364-4
	44298230	193000	0	None	-79	3	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	492	3	1	4	6.0	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Br)c(C(F)(F)F)cc32)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL53152	193000	0	None	-79	3	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	492	3	1	4	6.0	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Br)c(C(F)(F)F)cc32)cn1	10.1016/s0960-894x(00)00364-4
	44298022	193885	0	None	-63	3	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	422	5	1	4	5.8	CCCc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(C)c(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL55472	193885	0	None	-63	3	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	422	5	1	4	5.8	CCCc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(C)c(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
	18931133	167468	0	None	-10	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	465	9	2	6	3.4	COc1cc(OC)c(-c2ccccc2)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
	CHEMBL432217	167468	0	None	-10	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	465	9	2	6	3.4	COc1cc(OC)c(-c2ccccc2)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
	145977338	163165	0	None	19	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	259	3	2	4	2.2	Oc1ccccc1C1=NC(Cc2c[nH]cn2)CS1	10.1021/acs.jnatprod.7b00317
	CHEMBL4205064	163165	0	None	19	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	259	3	2	4	2.2	Oc1ccccc1C1=NC(Cc2c[nH]cn2)CS1	10.1021/acs.jnatprod.7b00317
	145963830	163571	0	None	7	7	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	335	4	2	4	4.0	Oc1ccccc1C1=NC(Cc2c[nH]cn2)C(c2ccccc2)S1	10.1021/acs.jnatprod.7b00317
	CHEMBL4209942	163571	0	None	7	7	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	335	4	2	4	4.0	Oc1ccccc1C1=NC(Cc2c[nH]cn2)C(c2ccccc2)S1	10.1021/acs.jnatprod.7b00317
	193	3450	38	None	-707	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cellsDisplacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1021/jm970424c
	3644637	3450	38	None	-707	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cellsDisplacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1021/jm970424c
	CHEMBL14563	3450	38	None	-707	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cellsDisplacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1021/jm970424c
	11419526	87628	0	None	-100	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.3	COc1ccc(N2Cc3ccc(Cl)c(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	CHEMBL234533	87628	0	None	-100	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.3	COc1ccc(N2Cc3ccc(Cl)c(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	16215237	87747	0	None	-39	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	462	6	0	4	5.6	COc1ccc(N2Cc3cc(Cl)c(Cl)c(C)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	CHEMBL234738	87747	0	None	-39	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	462	6	0	4	5.6	COc1ccc(N2Cc3cc(Cl)c(Cl)c(C)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	10503674	98369	0	None	-3	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	449	3	1	3	5.6	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3c(F)cccc3F)c1)CC2	10.1021/jm990388c
	CHEMBL278685	98369	0	None	-3	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	449	3	1	3	5.6	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3c(F)cccc3F)c1)CC2	10.1021/jm990388c
	9813197	96088	5	None	-11	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	215	0	1	1	2.7	Clc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
	CHEMBL262862	96088	5	None	-11	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	215	0	1	1	2.7	Clc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
	25122651	198565	0	None	-23	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	406	3	2	5	3.5	NC1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)CC1	10.1021/jm901674f
	CHEMBL597002	198565	0	None	-23	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	406	3	2	5	3.5	NC1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)CC1	10.1021/jm901674f
	67268994	163416	2	None	-3	7	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4207884	163416	2	None	-3	7	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	44298108	100457	0	None	-39	2	Human	7.0	pKi	=	7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	394	4	1	4	4.6	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL293937	100457	0	None	-39	2	Human	7.0	pKi	=	7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	394	4	1	4	4.6	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	44298092	101499	0	None	-19	2	Human	7.0	pKi	=	7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	400	4	1	5	4.7	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3nccs3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL301409	101499	0	None	-19	2	Human	7.0	pKi	=	7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	400	4	1	5	4.7	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3nccs3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	162663486	181417	0	None	-	1	Human	6.0	pKi	=	6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	348	4	1	3	4.7	O=c1cc(CCCc2cccc(C(F)(F)F)c2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
	CHEMBL4780527	181417	0	None	-	1	Human	6.0	pKi	=	6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	348	4	1	3	4.7	O=c1cc(CCCc2cccc(C(F)(F)F)c2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
	162672422	182599	0	None	-1	2	Human	6.0	pKi	=	6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	310	5	1	4	3.7	COc1ccc(CCCc2cc(=O)c3c(O)cccc3o2)cc1	10.1016/j.bmcl.2020.127511
	CHEMBL4795598	182599	0	None	-1	2	Human	6.0	pKi	=	6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	310	5	1	4	3.7	COc1ccc(CCCc2cc(=O)c3c(O)cccc3o2)cc1	10.1016/j.bmcl.2020.127511
	24888181	79714	0	None	-158	3	Human	6.0	pKi	=	6	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	410	7	0	4	4.1	COc1ccc(N2CC=C(c3ccc(F)cc3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	CHEMBL213272	79714	0	None	-158	3	Human	6.0	pKi	=	6	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	410	7	0	4	4.1	COc1ccc(N2CC=C(c3ccc(F)cc3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	24887525	79959	0	None	-199	3	Human	6.0	pKi	=	6	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	476	7	0	4	5.6	COc1ccc(N2CCC(C)(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	CHEMBL214398	79959	0	None	-199	3	Human	6.0	pKi	=	6	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	476	7	0	4	5.6	COc1ccc(N2CCC(C)(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	9888494	97719	0	None	-446	13	Human	6.0	pKi	=	6	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor was determinedBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor was determined	ChEMBL	422	4	1	5	3.6	O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL273921	97719	0	None	-446	13	Human	6.0	pKi	=	6	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor was determinedBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor was determined	ChEMBL	422	4	1	5	3.6	O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
	11168182	3478	18	None	-158	13	Human	6.0	pKi	=	6	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HT	ChEMBL	511	14	1	3	6.5	CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C	10.1016/j.bmcl.2005.06.024
	264	3478	18	None	-158	13	Human	6.0	pKi	=	6	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HT	ChEMBL	511	14	1	3	6.5	CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C	10.1016/j.bmcl.2005.06.024
	CHEMBL1181770	3478	18	None	-158	13	Human	6.0	pKi	=	6	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HT	ChEMBL	511	14	1	3	6.5	CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C	10.1016/j.bmcl.2005.06.024
	6918648	101089	1	None	-1621	14	Human	6.0	pKi	=	6	Binding	Compound was tested for its binding affinity against cloned human 5-hydroxytryptamine 2B receptor in HEK 293 cells using [3H]5-HTCompound was tested for its binding affinity against cloned human 5-hydroxytryptamine 2B receptor in HEK 293 cells using [3H]5-HT	ChEMBL	465	5	1	6	4.4	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1	10.1021/jm980532e
	CHEMBL29846	101089	1	None	-1621	14	Human	6.0	pKi	=	6	Binding	Compound was tested for its binding affinity against cloned human 5-hydroxytryptamine 2B receptor in HEK 293 cells using [3H]5-HTCompound was tested for its binding affinity against cloned human 5-hydroxytryptamine 2B receptor in HEK 293 cells using [3H]5-HT	ChEMBL	465	5	1	6	4.4	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1	10.1021/jm980532e
	145972374	164122	0	None	-3	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	388	6	3	7	1.3	COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H]1N=C(c2ccccc2O)S[C@@H]1C	10.1021/acs.jnatprod.7b00317
	CHEMBL4216860	164122	0	None	-3	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	388	6	3	7	1.3	COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H]1N=C(c2ccccc2O)S[C@@H]1C	10.1021/acs.jnatprod.7b00317
	136054961	57021	4	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	220	2	2	4	1.6	NC(=O)c1csc(-c2ccccc2O)n1	10.1021/acs.jnatprod.7b00317
	CHEMBL1651091	57021	4	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	220	2	2	4	1.6	NC(=O)c1csc(-c2ccccc2O)n1	10.1021/acs.jnatprod.7b00317
	153287535	174328	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	0	1	3	2.0	CN1CC[C@H]2c3ccc(O)cc3OC[C@]21C	10.1021/acsmedchemlett.9b00225
	CHEMBL4564308	174328	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	0	1	3	2.0	CN1CC[C@H]2c3ccc(O)cc3OC[C@]21C	10.1021/acsmedchemlett.9b00225
	23462894	156689	3	None	-15	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	240	1	0	3	2.3	CN1CCc2ccc([N+](=O)[O-])c(Cl)c2CC1	10.1016/j.bmc.2007.12.009
	CHEMBL407636	156689	3	None	-15	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	240	1	0	3	2.3	CN1CCc2ccc([N+](=O)[O-])c(Cl)c2CC1	10.1016/j.bmc.2007.12.009
	9934284	89865	0	None	-2511	10	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
	CHEMBL238520	89865	0	None	-2511	10	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
	76325517	105252	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	272	3	1	4	3.3	O=c1cc(CCc2cccs2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
	CHEMBL3126302	105252	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	272	3	1	4	3.3	O=c1cc(CCc2cccs2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
	118278480	121497	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	282	3	2	4	3.0	O=c1cc(CCc2ccc(O)cc2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
	CHEMBL3593950	121497	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	282	3	2	4	3.0	O=c1cc(CCc2ccc(O)cc2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
	44453877	155076	0	None	-19	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	305	2	1	3	3.6	Fc1ccc(-c2nc(-c3ccccc3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL404582	155076	0	None	-19	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	305	2	1	3	3.6	Fc1ccc(-c2nc(-c3ccccc3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
	44298151	100398	0	None	-31	2	Human	6.0	pKi	=	6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	380	4	1	4	4.3	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2cc(Cl)ccc21	10.1016/s0960-894x(00)00365-6
	CHEMBL293597	100398	0	None	-31	2	Human	6.0	pKi	=	6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	380	4	1	4	4.3	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2cc(Cl)ccc21	10.1016/s0960-894x(00)00365-6
	44298158	192906	0	None	-12	3	Human	6.0	pKi	=	6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	380	4	1	4	4.3	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2c(Cl)cccc21	10.1016/s0960-894x(00)00365-6
	CHEMBL52783	192906	0	None	-12	3	Human	6.0	pKi	=	6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	380	4	1	4	4.3	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2c(Cl)cccc21	10.1016/s0960-894x(00)00365-6
	6918648	101089	1	None	-1621	14	Human	6.0	pKi	=	6	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	465	5	1	6	4.4	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1	10.1016/s0960-894x(02)00172-5
	CHEMBL29846	101089	1	None	-1621	14	Human	6.0	pKi	=	6	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	465	5	1	6	4.4	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1	10.1016/s0960-894x(02)00172-5
	3233	3456	40	None	-165	12	Human	5.0	pKi	=	5	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandBinding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
	3247	3456	40	None	-165	12	Human	5.0	pKi	=	5	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandBinding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
	6604889	3456	40	None	-165	12	Human	5.0	pKi	=	5	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandBinding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
	CHEMBL282199	3456	40	None	-165	12	Human	5.0	pKi	=	5	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandBinding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
	DB13988	3456	40	None	-165	12	Human	5.0	pKi	=	5	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandBinding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
	16063047	94939	0	None	-77	3	Human	5.0	pKi	=	5	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	333	3	1	3	3.9	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CNCCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL256811	94939	0	None	-77	3	Human	5.0	pKi	=	5	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	333	3	1	3	3.9	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CNCCC3)cc1	10.1016/j.bmcl.2008.01.090
	122483292	137583	0	None	-3	7	Human	7.0	pKi	=	7	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3764335	137583	0	None	-3	7	Human	7.0	pKi	=	7	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765876	137583	0	None	-3	7	Human	7.0	pKi	=	7	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	141	1399	32	None	-1	21	Human	7.0	pKi	=	7	Binding	Compound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptorCompound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptor	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/jm980692q
	6089	1399	32	None	-1	21	Human	7.0	pKi	=	7	Binding	Compound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptorCompound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptor	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/jm980692q
	CHEMBL12420	1399	32	None	-1	21	Human	7.0	pKi	=	7	Binding	Compound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptorCompound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptor	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/jm980692q
	DB01488	1399	32	None	-1	21	Human	7.0	pKi	=	7	Binding	Compound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptorCompound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptor	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/jm980692q
	136054961	57021	4	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	220	2	2	4	1.6	NC(=O)c1csc(-c2ccccc2O)n1	10.1021/np100588c
	CHEMBL1651091	57021	4	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	220	2	2	4	1.6	NC(=O)c1csc(-c2ccccc2O)n1	10.1021/np100588c
	73213196	103981	1	None	1	13	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5-HT2B receptor (unknown origin)Binding affinity to 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2014.05.016
	CHEMBL3104093	103981	1	None	1	13	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5-HT2B receptor (unknown origin)Binding affinity to 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2014.05.016
	73213196	103981	1	None	1	13	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
	CHEMBL3104093	103981	1	None	1	13	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
	73213196	103981	1	None	1	13	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
	CHEMBL3104093	103981	1	None	1	13	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
	142601343	185021	0	None	-36	7	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4863868	185021	0	None	-36	7	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	71455083	81418	0	None	-173	7	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5HT2B receptor by radioligand binding assayBinding affinity to 5HT2B receptor by radioligand binding assay	ChEMBL	389	6	0	3	4.8	O=C(C1CCCCC1)N(CCN1CC=C(c2ccccc2)CC1)c1ccccn1	10.1016/j.bmcl.2012.05.119
	CHEMBL2164354	81418	0	None	-173	7	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5HT2B receptor by radioligand binding assayBinding affinity to 5HT2B receptor by radioligand binding assay	ChEMBL	389	6	0	3	4.8	O=C(C1CCCCC1)N(CCN1CC=C(c2ccccc2)CC1)c1ccccn1	10.1016/j.bmcl.2012.05.119
	2520	202310	65	None	-4	11	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
	CHEMBL1280	202310	65	None	-4	11	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
	CHEMBL6966	202310	65	None	-4	11	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
	118055295	177498	0	None	-17	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	242	0	1	2	2.2	FC(F)(F)c1ccc2c3c1CCN3CCNC2	10.1016/j.bmcl.2019.126929
	CHEMBL4647417	177498	0	None	-17	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	242	0	1	2	2.2	FC(F)(F)c1ccc2c3c1CCN3CCNC2	10.1016/j.bmcl.2019.126929
	11324968	90654	0	None	1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	Cc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397880	90654	0	None	1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	Cc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	168285382	190924	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	425	9	0	5	5.4	CCCCCCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	CHEMBL5194057	190924	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	425	9	0	5	5.4	CCCCCCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	44582707	186415	0	None	1	4	Human	6.0	pKi	=	6.0	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	430	10	0	6	4.1	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL490634	186415	0	None	1	4	Human	6.0	pKi	=	6.0	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	430	10	0	6	4.1	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1	10.1016/j.bmc.2009.03.021
	13091359	113040	0	None	-1479	10	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
	CHEMBL3321790	113040	0	None	-1479	10	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
	53251189	130372	3	None	-	1	Human	6.0	pKi	=	6.0	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000704a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000704a HTR2B	ChEMBL	452	5	3	7	5.1	Cc1cc(Nc2nccc(C)n2)cc(-c2cnc([C@@]3(O)CC[C@H](C(=O)O)C(C)(C)C3)s2)c1	nan
	CHEMBL3685796	130372	3	None	-	1	Human	6.0	pKi	=	6.0	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000704a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000704a HTR2B	ChEMBL	452	5	3	7	5.1	Cc1cc(Nc2nccc(C)n2)cc(-c2cnc([C@@]3(O)CC[C@H](C(=O)O)C(C)(C)C3)s2)c1	nan
	135367405	163644	0	None	-2	7	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4210782	163644	0	None	-2	7	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	122179556	120974	0	None	2	2	Human	6.0	pKi	=	6.0	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000733a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000733a HTR2B	ChEMBL	303	2	0	3	4.5	FC(F)(F)c1ccc2c(c1)nc(-c1cccnc1)n2C1CC1	nan
	CHEMBL3582461	120974	0	None	2	2	Human	6.0	pKi	=	6.0	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000733a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000733a HTR2B	ChEMBL	303	2	0	3	4.5	FC(F)(F)c1ccc2c(c1)nc(-c1cccnc1)n2C1CC1	nan
	15560577	184759	6	None	1	7	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	398	5	1	5	3.8	CC[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	CHEMBL4859858	184759	6	None	1	7	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	398	5	1	5	3.8	CC[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	123683	3072	58	None	-12302	13	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5HT2B receptor (unknown origin) by PDSP screeningBinding affinity to 5HT2B receptor (unknown origin) by PDSP screening	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1021/jm501021n
	422	3072	58	None	-12302	13	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5HT2B receptor (unknown origin) by PDSP screeningBinding affinity to 5HT2B receptor (unknown origin) by PDSP screening	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1021/jm501021n
	CHEMBL119709	3072	58	None	-12302	13	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5HT2B receptor (unknown origin) by PDSP screeningBinding affinity to 5HT2B receptor (unknown origin) by PDSP screening	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1021/jm501021n
	DB05511	3072	58	None	-12302	13	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5HT2B receptor (unknown origin) by PDSP screeningBinding affinity to 5HT2B receptor (unknown origin) by PDSP screening	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1021/jm501021n
	123683	3072	58	None	-12302	13	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1021/acs.jmedchem.6b01183
	422	3072	58	None	-12302	13	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1021/acs.jmedchem.6b01183
	CHEMBL119709	3072	58	None	-12302	13	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1021/acs.jmedchem.6b01183
	DB05511	3072	58	None	-12302	13	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1021/acs.jmedchem.6b01183
	16115652	83078	0	None	-27	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	286	1	1	3	1.8	COc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL220211	83078	0	None	-27	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	286	1	1	3	1.8	COc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	71061724	145019	0	None	1	5	Mouse	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	386	5	0	4	3.0	O=C(CN1CCO[C@H](COc2cccc(Cl)c2)C1)N1CCc2ccccc21	nan
	CHEMBL3915107	145019	0	None	1	5	Mouse	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	386	5	0	4	3.0	O=C(CN1CCO[C@H](COc2cccc(Cl)c2)C1)N1CCc2ccccc21	nan
	10660	14298	55	None	-29	12	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
	CHEMBL1200406	14298	55	None	-29	12	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
	134138168	147158	0	None	1	10	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL3931889	147158	0	None	1	10	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	44397832	122593	0	None	-7	3	Human	8.0	pKi	=	8.0	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	256	0	1	2	2.4	C[C@@H]1CNC[C@H]2Cc3ccc(C(F)(F)F)cc3N12	10.1016/j.bmcl.2005.05.074
	CHEMBL361079	122593	0	None	-7	3	Human	8.0	pKi	=	8.0	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	256	0	1	2	2.4	C[C@@H]1CNC[C@H]2Cc3ccc(C(F)(F)F)cc3N12	10.1016/j.bmcl.2005.05.074
	118706287	120020	0	None	14	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccc(Cl)cc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310114	120020	0	None	14	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccc(Cl)cc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545466	120020	0	None	14	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccc(Cl)cc1-2	10.1016/j.bmc.2014.05.027
	10131066	21403	0	None	-4	3	Human	8.0	pKi	=	8.0	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	244	2	1	3	2.4	CC(N)Cc1cn(C)c2ccc3c(c12)CCCO3	10.1021/jm030205t
	CHEMBL131736	21403	0	None	-4	3	Human	8.0	pKi	=	8.0	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	244	2	1	3	2.4	CC(N)Cc1cn(C)c2ccc3c(c12)CCCO3	10.1021/jm030205t
	134141831	146154	0	None	2	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	405	6	4	8	1.4	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3923870	146154	0	None	2	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	405	6	4	8	1.4	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	45486902	195271	0	None	-3	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	449	5	2	4	4.6	O=c1[nH]c2cccc(OCC3CCN(CC4CCc5[nH]c6ccc(F)cc6c5C4)CC3)c2o1	10.1016/j.bmcl.2009.08.050
	CHEMBL566396	195271	0	None	-3	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	449	5	2	4	4.6	O=c1[nH]c2cccc(OCC3CCN(CC4CCc5[nH]c6ccc(F)cc6c5C4)CC3)c2o1	10.1016/j.bmcl.2009.08.050
	118729270	120190	0	None	-1	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(F)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402678	120190	0	None	-1	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(F)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547139	120190	0	None	-1	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(F)c2)C1	10.1016/j.bmc.2015.01.060
	145965628	163495	0	None	-4	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	333	4	1	3	4.6	C[C@@H]1SC(c2ccc(-c3ccccc3)cc2)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	CHEMBL4208914	163495	0	None	-4	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	333	4	1	3	4.6	C[C@@H]1SC(c2ccc(-c3ccccc3)cc2)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	146025727	171119	0	None	-40	27	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4466483	171119	0	None	-40	27	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	132060743	161686	0	None	-4	13	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	351	3	0	4	3.1	CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1	10.1016/j.ejmech.2018.02.024
	CHEMBL4163428	161686	0	None	-4	13	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	351	3	0	4	3.1	CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1	10.1016/j.ejmech.2018.02.024
	10541003	102644	0	None	-2	3	Human	5.0	pKi	=	5.0	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligand	ChEMBL	283	1	1	3	2.2	COc1cc(Br)c2c3c1C[C@H](N)C[C@H]3CO2	10.1021/jm980076u
	CHEMBL307770	102644	0	None	-2	3	Human	5.0	pKi	=	5.0	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligand	ChEMBL	283	1	1	3	2.2	COc1cc(Br)c2c3c1C[C@H](N)C[C@H]3CO2	10.1021/jm980076u
	136118640	75965	0	None	3	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	335	1	2	3	3.1	CSC1=NC(=O)/C(=C/c2c[nH]c3cc(Br)ccc23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2058700	75965	0	None	3	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	335	1	2	3	3.1	CSC1=NC(=O)/C(=C/c2c[nH]c3cc(Br)ccc23)N1	10.1016/j.bmc.2013.09.011
	21044391	76278	0	None	-21	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	219	1	2	4	0.3	C[C@@H]1CNC[C@H]2Cc3ccc(CO)nc3N12	10.1016/j.bmcl.2005.11.083
	CHEMBL206386	76278	0	None	-21	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	219	1	2	4	0.3	C[C@@H]1CNC[C@H]2Cc3ccc(CO)nc3N12	10.1016/j.bmcl.2005.11.083
	2333	141803	91	None	1	2	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	nan
	CHEMBL388590	141803	91	None	1	2	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	nan
	11313985	90652	0	None	-3	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	232	1	1	3	0.7	COc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397878	90652	0	None	-3	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	232	1	1	3	0.7	COc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	18715561	72697	0	None	-4	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3cccnc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL201062	72697	0	None	-4	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3cccnc3c21	10.1016/j.bmcl.2005.10.029
	46914774	15268	0	None	21	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	364	7	0	4	4.5	CCCOc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
	CHEMBL1215037	15268	0	None	21	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	364	7	0	4	4.5	CCCOc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
	16115269	137601	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	CHEMBL376676	137601	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	21786603	134340	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	259	3	2	3	1.7	CN1CCN(CCc2c[nH]c3cccc(O)c23)CC1	10.1016/j.bmcl.2005.06.104
	CHEMBL371899	134340	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	259	3	2	3	1.7	CN1CCN(CCc2c[nH]c3cccc(O)c23)CC1	10.1016/j.bmcl.2005.06.104
	127051592	140347	0	None	-51	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818710	140347	0	None	-51	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819742	140347	0	None	-51	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	2771	193347	67	None	1	26	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	nan
	CHEMBL1200781	193347	67	None	1	26	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	nan
	CHEMBL549	193347	67	None	1	26	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	nan
	127051592	140347	0	None	-51	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818710	140347	0	None	-51	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819742	140347	0	None	-51	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	104903	56050	14	None	-4	6	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	nan
	CHEMBL1630578	56050	14	None	-4	6	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	nan
	58911534	90678	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	Cc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397904	90678	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	Cc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	2723	153512	104	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	156	0	1	1	2.7	Cc1cc(O)cc(C)c1Cl	nan
	CHEMBL398440	153512	104	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	156	0	1	1	2.7	Cc1cc(O)cc(C)c1Cl	nan
	1379258	67453	13	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	293	3	0	1	4.1	Cc1ccccc1C(=O)N1CCC(Cc2ccccc2)CC1	nan
	CHEMBL1909050	67453	13	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	293	3	0	1	4.1	Cc1ccccc1C(=O)N1CCC(Cc2ccccc2)CC1	nan
	16754	85148	43	None	-2	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	355	4	0	5	3.5	COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL228082	85148	43	None	-2	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	355	4	0	5	3.5	COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	5	139	66	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	5202	139	66	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	CHEMBL39	139	66	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	DB08839	139	66	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	CHEMBL5081379	212974	0	None	-1	9	Human	7.9	pKi	=	7.9	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	58405183	110208	0	None	-2	4	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	339	6	1	3	3.9	FC(F)(COc1ccc(Cl)cc1OC1CNC1)c1ccccc1	10.1021/ml500082j
	CHEMBL3260336	110208	0	None	-2	4	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	339	6	1	3	3.9	FC(F)(COc1ccc(Cl)cc1OC1CNC1)c1ccccc1	10.1021/ml500082j
	11380477	179102	0	None	-2	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	280	2	1	4	2.7	CC(C)n1nc2c(c1-c1ccc(C#N)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4743582	179102	0	None	-2	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	280	2	1	4	2.7	CC(C)n1nc2c(c1-c1ccc(C#N)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	5	139	66	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2005.10.029
	5202	139	66	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2005.10.029
	CHEMBL39	139	66	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2005.10.029
	DB08839	139	66	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2005.10.029
	10198431	73557	0	None	-7	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL201930	73557	0	None	-7	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	189	3436	31	None	-5	17	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1016/j.bmcl.2013.12.024
	5163	3436	31	None	-5	17	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1016/j.bmcl.2013.12.024
	CHEMBL297784	3436	31	None	-5	17	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1016/j.bmcl.2013.12.024
	11625624	112589	0	None	-17	7	Human	7.9	pKi	=	7.9	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	406	4	4	8	0.9	CNC(=O)[C@]12C[C@@H]1[C@@H](n1cnc3c(NC4CCCC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	CHEMBL331291	112589	0	None	-17	7	Human	7.9	pKi	=	7.9	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	406	4	4	8	0.9	CNC(=O)[C@]12C[C@@H]1[C@@H](n1cnc3c(NC4CCCC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	189	3436	31	None	-5	17	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1016/j.bmcl.2013.12.024
	5163	3436	31	None	-5	17	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1016/j.bmcl.2013.12.024
	CHEMBL297784	3436	31	None	-5	17	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1016/j.bmcl.2013.12.024
	10741816	97738	0	None	-5	3	Human	7.9	pKi	=	7.9	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	441	3	1	3	6.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3c(C)ccnc3C)c1)CC2	10.1021/jm990388c
	CHEMBL274066	97738	0	None	-5	3	Human	7.9	pKi	=	7.9	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	441	3	1	3	6.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3c(C)ccnc3C)c1)CC2	10.1021/jm990388c
	10549658	97831	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	413	3	1	3	5.4	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(-c3ccncc3)cc1)CC2	10.1021/jm990388c
	CHEMBL274692	97831	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	413	3	1	3	5.4	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(-c3ccncc3)cc1)CC2	10.1021/jm990388c
	18475509	101477	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	318	2	2	3	3.9	CN1CCc2cc(NC(=O)Nc3ccnc4ccccc34)ccc21	10.1016/s0960-894x(01)00343-2
	CHEMBL301209	101477	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	318	2	2	3	3.9	CN1CCc2cc(NC(=O)Nc3ccnc4ccccc34)ccc21	10.1016/s0960-894x(01)00343-2
	191	3442	47	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	10.1021/jm970741j
	443389	3442	47	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	10.1021/jm970741j
	CHEMBL276140	3442	47	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	10.1021/jm970741j
	44298172	101301	0	None	-6	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	429	3	1	5	4.9	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cncnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL299938	101301	0	None	-6	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	429	3	1	5	4.9	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cncnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	44298163	193730	0	None	-25	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.5	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cnccc3Cl)nc1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL55207	193730	0	None	-25	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.5	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cnccc3Cl)nc1)CC2	10.1016/s0960-894x(00)00364-4
	191	3442	47	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cellsDisplacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells	ChEMBL	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	10.1021/jm970424c
	443389	3442	47	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cellsDisplacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells	ChEMBL	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	10.1021/jm970424c
	CHEMBL276140	3442	47	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cellsDisplacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells	ChEMBL	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	10.1021/jm970424c
	9887537	83927	38	None	-15	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	405	4	0	5	4.0	Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1	10.1021/jm070516u
	CHEMBL221692	83927	38	None	-15	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	405	4	0	5	4.0	Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1	10.1021/jm070516u
	CHEMBL4751170	83927	38	None	-15	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	405	4	0	5	4.0	Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1	10.1021/jm070516u
	44298246	193936	0	None	-2	3	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	397	4	1	5	4.0	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3nccn3C)nc1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL55597	193936	0	None	-2	3	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	397	4	1	5	4.0	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3nccn3C)nc1)CC2	10.1016/s0960-894x(00)00365-6
	56658155	65332	0	None	13	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	350	6	0	4	3.8	COc1ccccc1CCN1CCN(Cc2cc3ccccc3o2)CC1	10.1016/j.bmcl.2011.08.029
	CHEMBL1834252	65332	0	None	13	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	350	6	0	4	3.8	COc1ccccc1CCN1CCN(Cc2cc3ccccc3o2)CC1	10.1016/j.bmcl.2011.08.029
	145972796	164044	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	236	3	2	4	2.0	CNc1ccccc1C1=N[C@@H](CO)[C@H](C)S1	10.1021/acs.jnatprod.7b00317
	CHEMBL4215741	164044	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	236	3	2	4	2.0	CNc1ccccc1C1=N[C@@H](CO)[C@H](C)S1	10.1021/acs.jnatprod.7b00317
	71212556	143030	0	None	-24	6	Human	6.9	pKi	=	6.9	Binding	Binding Assay or Functional Activity Assay: Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologically important receptors such as, but not limited to, the hERG channel, other serotonin receptors (specifically 5-HT1B, 5-HT1D, receptors, lack of agonist activity at 5-HT2B receptors, 5-HT2C, 5-HT5, 5-HT6, and 5-HT7 receptors), dopaminergic receptors (specifically D1, D2, and D3), GABAA receptors, adrenergic receptors and monoamine transporters.Binding Assay or Functional Activity Assay: Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologically important receptors such as, but not limited to, the hERG channel, other serotonin receptors (specifically 5-HT1B, 5-HT1D, receptors, lack of agonist activity at 5-HT2B receptors, 5-HT2C, 5-HT5, 5-HT6, and 5-HT7 receptors), dopaminergic receptors (specifically D1, D2, and D3), GABAA receptors, adrenergic receptors and monoamine transporters.	ChEMBL	433	3	1	6	4.6	Cc1ccc2c(c1)Oc1sc(Cl)cc1C(N1CCN(CC(C)(C)C(=O)O)CC1)=N2	nan
	CHEMBL3899169	143030	0	None	-24	6	Human	6.9	pKi	=	6.9	Binding	Binding Assay or Functional Activity Assay: Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologically important receptors such as, but not limited to, the hERG channel, other serotonin receptors (specifically 5-HT1B, 5-HT1D, receptors, lack of agonist activity at 5-HT2B receptors, 5-HT2C, 5-HT5, 5-HT6, and 5-HT7 receptors), dopaminergic receptors (specifically D1, D2, and D3), GABAA receptors, adrenergic receptors and monoamine transporters.Binding Assay or Functional Activity Assay: Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologically important receptors such as, but not limited to, the hERG channel, other serotonin receptors (specifically 5-HT1B, 5-HT1D, receptors, lack of agonist activity at 5-HT2B receptors, 5-HT2C, 5-HT5, 5-HT6, and 5-HT7 receptors), dopaminergic receptors (specifically D1, D2, and D3), GABAA receptors, adrenergic receptors and monoamine transporters.	ChEMBL	433	3	1	6	4.6	Cc1ccc2c(c1)Oc1sc(Cl)cc1C(N1CCN(CC(C)(C)C(=O)O)CC1)=N2	nan
	155561439	175093	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cell by radioligand binding assayDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cell by radioligand binding assay	ChEMBL	411	4	4	7	3.5	Oc1ccc(CCNc2nc(C#Cc3ccc(Cl)s3)nc3[nH]cnc23)cc1O	10.1039/C8MD00317C
	CHEMBL4581568	175093	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cell by radioligand binding assayDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cell by radioligand binding assay	ChEMBL	411	4	4	7	3.5	Oc1ccc(CCNc2nc(C#Cc3ccc(Cl)s3)nc3[nH]cnc23)cc1O	10.1039/C8MD00317C
	44404899	70089	2	None	-70	4	Human	5.9	pKi	=	5.9	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	190	2	2	2	1.9	CN(C)Cc1c[nH]c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL194588	70089	2	None	-70	4	Human	5.9	pKi	=	5.9	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	190	2	2	2	1.9	CN(C)Cc1c[nH]c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
	44404904	132490	1	None	-11	3	Human	5.9	pKi	=	5.9	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	204	2	1	3	1.9	CN(C)Cc1cn(C)c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL370221	132490	1	None	-11	3	Human	5.9	pKi	=	5.9	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	204	2	1	3	1.9	CN(C)Cc1cn(C)c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
	127050699	140341	0	None	-14	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	3	0	1	4.0	Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2	10.1016/j.bmc.2016.05.053
	CHEMBL3819082	140341	0	None	-14	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	3	0	1	4.0	Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2	10.1016/j.bmc.2016.05.053
	CHEMBL3819726	140341	0	None	-14	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	3	0	1	4.0	Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2	10.1016/j.bmc.2016.05.053
	117209918	185828	1	None	-3	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876036	185828	1	None	-3	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	135508617 136016503	10530	0	None	-2	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.6	CN1C(=N)N(C)/C(=C/c2c[nH]c3ccc(Br)cc23)C1=O	10.1016/j.bmc.2013.09.011
	CHEMBL1170237	10530	0	None	-2	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.6	CN1C(=N)N(C)/C(=C/c2c[nH]c3ccc(Br)cc23)C1=O	10.1016/j.bmc.2013.09.011
	9869628	71699	0	None	-199	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	440	7	0	4	4.8	COc1cc2c(cc1OCCN1CCCCC1)N(C(=O)/C=C/c1ccccc1Cl)CC2	10.1016/j.bmcl.2005.08.004
	CHEMBL197630	71699	0	None	-199	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	440	7	0	4	4.8	COc1cc2c(cc1OCCN1CCCCC1)N(C(=O)/C=C/c1ccccc1Cl)CC2	10.1016/j.bmcl.2005.08.004
	10127968	71875	0	None	-15	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	479	7	0	5	4.2	COc1ccc(N2CCN(c3ccc(C)c(C(F)(F)F)c3)C2=O)cc1OCCN1CCOCC1	10.1016/j.bmcl.2005.08.004
	CHEMBL198109	71875	0	None	-15	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	479	7	0	5	4.2	COc1ccc(N2CCN(c3ccc(C)c(C(F)(F)F)c3)C2=O)cc1OCCN1CCOCC1	10.1016/j.bmcl.2005.08.004
	10479409	77709	0	None	-25	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	460	7	0	4	5.3	COc1ccc(C2=CCN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	CHEMBL210007	77709	0	None	-25	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	460	7	0	4	5.3	COc1ccc(C2=CCN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	49850874	56168	0	None	-398	9	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	450	6	1	4	5.2	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccccc5)c4)CC3)cccc2n1	10.1021/jm100714c
	CHEMBL1632210	56168	0	None	-398	9	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	450	6	1	4	5.2	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccccc5)c4)CC3)cccc2n1	10.1021/jm100714c
	44298243	100195	0	None	-100	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	394	3	1	4	5.1	Cc1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(Oc2cccnc2C)nc1	10.1016/s0960-894x(00)00364-4
	CHEMBL292228	100195	0	None	-100	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	394	3	1	4	5.1	Cc1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(Oc2cccnc2C)nc1	10.1016/s0960-894x(00)00364-4
	44298254	192940	0	None	-50	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	442	4	1	4	5.8	CCc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL52919	192940	0	None	-50	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	442	4	1	4	5.8	CCc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	22619858	197396	0	None	-39	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	429	3	1	5	4.9	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nn1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL58765	197396	0	None	-39	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	429	3	1	5	4.9	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nn1)CC2	10.1016/s0960-894x(00)00364-4
	18931348	104262	0	None	-39	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	389	8	2	6	1.7	COc1ccc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)c1	10.1016/S0960-894X(96)00503-3
	CHEMBL310656	104262	0	None	-39	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	389	8	2	6	1.7	COc1ccc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)c1	10.1016/S0960-894X(96)00503-3
	44324011	111121	0	None	-12	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	562	11	3	8	2.7	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(F)cc1	10.1016/S0960-894X(96)00503-3
	CHEMBL328375	111121	0	None	-12	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	562	11	3	8	2.7	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(F)cc1	10.1016/S0960-894X(96)00503-3
	148302367	172949	0	None	15	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	267	2	1	2	4.0	CC[C@H]1c2cc(-c3ccccc3)ccc2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	CHEMBL4530979	172949	0	None	15	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	267	2	1	2	4.0	CC[C@H]1c2cc(-c3ccccc3)ccc2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	149396365	175431	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	295	3	1	3	3.5	C[C@@]12COc3cc(OCc4ccccc4)ccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	CHEMBL4589450	175431	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	295	3	1	3	3.5	C[C@@]12COc3cc(OCc4ccccc4)ccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	44430976	87613	0	None	-50	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.3	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCCC(C)C1	10.1016/j.bmcl.2006.10.029
	CHEMBL234492	87613	0	None	-50	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.3	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCCC(C)C1	10.1016/j.bmcl.2006.10.029
	11236301	87626	0	None	-63	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	450	6	0	4	4.9	COc1ccc(N2Cc3c(F)c(F)cc(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	CHEMBL234531	87626	0	None	-63	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	450	6	0	4	4.9	COc1ccc(N2Cc3c(F)c(F)cc(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	11475519	151543	0	None	-79	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	414	6	0	4	4.6	COc1ccc(N2Cc3cccc(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	CHEMBL396747	151543	0	None	-79	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	414	6	0	4	4.6	COc1ccc(N2Cc3cccc(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	44430979	152658	0	None	-19	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	462	6	0	4	5.8	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1[C@@H](C)CCC[C@H]1C	10.1016/j.bmcl.2006.10.029
	CHEMBL397709	152658	0	None	-19	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	462	6	0	4	5.8	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1[C@@H](C)CCC[C@H]1C	10.1016/j.bmcl.2006.10.029
	162654275	180098	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	310	5	1	4	3.7	COc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
	CHEMBL4755344	180098	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	310	5	1	4	3.7	COc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
	10287730	3480	36	None	-1584	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor Binding affinity for human 5-hydroxytryptamine 2B receptor	ChEMBL	412	6	0	5	4.3	Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2	10.1021/jm049039v
	77	3480	36	None	-1584	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor Binding affinity for human 5-hydroxytryptamine 2B receptor	ChEMBL	412	6	0	5	4.3	Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2	10.1021/jm049039v
	CHEMBL425190	3480	36	None	-1584	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor Binding affinity for human 5-hydroxytryptamine 2B receptor	ChEMBL	412	6	0	5	4.3	Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2	10.1021/jm049039v
	10217208	71869	0	None	-125	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	463	7	0	4	5.3	COc1ccc(N2CCN(c3cccc(Cl)c3Cl)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
	CHEMBL198097	71869	0	None	-125	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	463	7	0	4	5.3	COc1ccc(N2CCN(c3cccc(Cl)c3Cl)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
	44404608	71908	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	346	6	1	4	2.7	COc1ccc(N2CCN(c3cccc(F)c3)C2=O)cc1OCCO	10.1016/j.bmcl.2005.08.004
	CHEMBL198192	71908	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	346	6	1	4	2.7	COc1ccc(N2CCN(c3cccc(F)c3)C2=O)cc1OCCO	10.1016/j.bmcl.2005.08.004
	10309622	140842	0	None	-1000	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	395	7	0	4	4.0	COc1ccc(N2CCN(c3ccccc3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
	CHEMBL383800	140842	0	None	-1000	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	395	7	0	4	4.0	COc1ccc(N2CCN(c3ccccc3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
	44414209	80824	0	None	-398	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	424	7	0	4	4.4	COc1ccc(N2CC=C(c3ccc(F)cc3)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.05.034
	CHEMBL215864	80824	0	None	-398	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	424	7	0	4	4.4	COc1ccc(N2CC=C(c3ccc(F)cc3)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.05.034
	9891002	106924	0	None	-1258	7	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned 5-HT2B receptor in HEK 293 cells using [3H]- -5-HT as radioligandBinding affinity to human cloned 5-HT2B receptor in HEK 293 cells using [3H]- -5-HT as radioligand	ChEMBL	472	4	2	6	4.6	Cc1sc2ccc(Cl)cc2c1S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1	10.1016/s0960-894x(01)00558-3
	CHEMBL318018	106924	0	None	-1258	7	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned 5-HT2B receptor in HEK 293 cells using [3H]- -5-HT as radioligandBinding affinity to human cloned 5-HT2B receptor in HEK 293 cells using [3H]- -5-HT as radioligand	ChEMBL	472	4	2	6	4.6	Cc1sc2ccc(Cl)cc2c1S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1	10.1016/s0960-894x(01)00558-3
	11304596	56102	0	None	-7943	9	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	416	5	0	5	3.9	Cc1ccc2c(N3CCN(CCc4cccc(N5CCOC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
	CHEMBL1631542	56102	0	None	-7943	9	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	416	5	0	5	3.9	Cc1ccc2c(N3CCN(CCc4cccc(N5CCOC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
	9827938	11666	0	None	-50	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HT	ChEMBL	517	13	1	3	6.3	CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1	10.1016/j.bmcl.2005.06.024
	CHEMBL1181680	11666	0	None	-50	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HT	ChEMBL	517	13	1	3	6.3	CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1	10.1016/j.bmcl.2005.06.024
	CHEMBL188486	11666	0	None	-50	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HT	ChEMBL	517	13	1	3	6.3	CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1	10.1016/j.bmcl.2005.06.024
	2470	3596	46	None	-14125	59	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/S0960-894X(96)00503-3
	3300	3596	46	None	-14125	59	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/S0960-894X(96)00503-3
	5265	3596	46	None	-14125	59	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/S0960-894X(96)00503-3
	99	3596	46	None	-14125	59	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/S0960-894X(96)00503-3
	CHEMBL267930	3596	46	None	-14125	59	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/S0960-894X(96)00503-3
	10008294	205100	0	None	-63	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	574	12	3	9	2.5	COc1ccc(S(=O)(=O)Nc2cc(C(=O)CCCCN3CCC4(CC3)NC(=O)NC4=O)c(OC)cc2OC)cc1	10.1016/S0960-894X(96)00503-3
	CHEMBL90467	205100	0	None	-63	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	574	12	3	9	2.5	COc1ccc(S(=O)(=O)Nc2cc(C(=O)CCCCN3CCC4(CC3)NC(=O)NC4=O)c(OC)cc2OC)cc1	10.1016/S0960-894X(96)00503-3
	10371119	205279	0	None	-794	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	586	12	3	8	3.7	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(C(C)C)cc1	10.1016/S0960-894X(96)00503-3
	CHEMBL91454	205279	0	None	-794	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	586	12	3	8	3.7	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(C(C)C)cc1	10.1016/S0960-894X(96)00503-3
	127050699	140341	0	None	-14	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	3	0	1	4.0	Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2	10.1016/j.bmc.2016.05.053
	CHEMBL3819082	140341	0	None	-14	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	3	0	1	4.0	Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2	10.1016/j.bmc.2016.05.053
	CHEMBL3819726	140341	0	None	-14	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	3	0	1	4.0	Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2	10.1016/j.bmc.2016.05.053
	122182283	121496	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	282	3	2	4	3.0	O=c1cc(CCc2cccc(O)c2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
	CHEMBL3593949	121496	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	282	3	2	4	3.0	O=c1cc(CCc2cccc(O)c2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
	9935387	98983	0	None	-1584	14	Human	5.9	pKi	=	5.9	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	491	5	1	6	5.0	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1	10.1016/s0960-894x(02)00172-5
	CHEMBL282971	98983	0	None	-1584	14	Human	5.9	pKi	=	5.9	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	491	5	1	6	5.0	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1	10.1016/s0960-894x(02)00172-5
	9913554	100523	0	None	-1584	14	Human	5.9	pKi	=	5.9	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	491	5	1	6	5.0	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1	10.1016/s0960-894x(02)00172-5
	CHEMBL29433	100523	0	None	-1584	14	Human	5.9	pKi	=	5.9	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	491	5	1	6	5.0	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1	10.1016/s0960-894x(02)00172-5
	136030693	57022	1	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	222	2	2	4	0.7	NC(=O)C1CSC(c2ccccc2O)=N1	10.1021/np100588c
	CHEMBL1651092	57022	1	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	222	2	2	4	0.7	NC(=O)C1CSC(c2ccccc2O)=N1	10.1021/np100588c
	3034396	101168	33	None	-20	17	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	398	5	1	5	3.8	CC[C@@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	CHEMBL299031	101168	33	None	-20	17	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	398	5	1	5	3.8	CC[C@@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	1201549	590	22	None	-26	20	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	333	590	22	None	-26	20	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	7601	590	22	None	-26	20	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	CHEMBL1201203	590	22	None	-26	20	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	CHEMBL438151	590	22	None	-26	20	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	DB00245	590	22	None	-26	20	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	118055293	176671	0	None	-17	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	252	0	1	2	1.9	Brc1ccc2c3c1CCN3CCNC2	10.1016/j.bmcl.2019.126929
	CHEMBL4635854	176671	0	None	-17	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	252	0	1	2	1.9	Brc1ccc2c3c1CCN3CCNC2	10.1016/j.bmcl.2019.126929
	58911604	90675	0	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	236	0	1	2	1.3	O=C1c2ccc(Cl)cc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397901	90675	0	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	236	0	1	2	1.3	O=C1c2ccc(Cl)cc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	135846982	92623	0	None	7	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3cc(Br)ccc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2442268	92623	0	None	7	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3cc(Br)ccc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
	5510	204137	97	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	2	0	2	4.9	Cc1cccc(N(C)C(=S)Oc2ccc3ccccc3c2)c1	nan
	CHEMBL83668	204137	97	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	2	0	2	4.9	Cc1cccc(N(C)C(=S)Oc2ccc3ccccc3c2)c1	nan
	135846955	188893	4	None	7	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	240	1	3	2	1.5	CN1C(=N)N/C(=C/c2c[nH]c3ccccc23)C1=O	10.1016/j.bmc.2013.09.011
	CHEMBL513803	188893	4	None	7	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	240	1	3	2	1.5	CN1C(=N)N/C(=C/c2c[nH]c3ccccc23)C1=O	10.1016/j.bmc.2013.09.011
	4122	205891	102	None	-3	3	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	301	3	2	5	3.0	COC(=O)Nc1nc2ccc(C(=O)c3cccs3)cc2[nH]1	nan
	CHEMBL9514	205891	102	None	-3	3	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	301	3	2	5	3.0	COC(=O)Nc1nc2ccc(C(=O)c3cccs3)cc2[nH]1	nan
	71682216	90683	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	260	3	1	3	1.4	CCCOc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397909	90683	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	260	3	1	3	1.4	CCCOc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL4754103	212280	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000328a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000328a HTR2B	ChEMBL		None	None	None		CNC(=O)Nc1ccc2c(c1)CC[C@]21OC(=O)N(CC(=O)N(Cc2ccc(F)cc2)[C@@H](C)C(F)(F)F)C1=O	nan
	92042876	150804	0	None	-2	10	Human	7.9	pKi	=	7.9	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL3961059	150804	0	None	-2	10	Human	7.9	pKi	=	7.9	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	9920815	66913	0	None	-7	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	216	0	1	2	2.0	Cc1ccc2c(c1C)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
	CHEMBL188033	66913	0	None	-7	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	216	0	1	2	2.0	Cc1ccc2c(c1C)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
	5	139	66	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
	5202	139	66	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
	CHEMBL39	139	66	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
	DB08839	139	66	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
	152	361	18	None	1	18	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm050663x
	2107	361	18	None	1	18	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm050663x
	CHEMBL275854	361	18	None	1	18	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm050663x
	24826790	90663	0	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	Cc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397889	90663	0	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	Cc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	46230095	197611	0	None	11	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	271	0	2	3	1.2	O=C1NC2CNCCN2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2009.12.014
	CHEMBL590333	197611	0	None	11	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	271	0	2	3	1.2	O=C1NC2CNCCN2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2009.12.014
	127048336	140075	0	None	5	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	573	12	0	5	5.8	COc1ccc(CCN(CCCc2ccccc2I)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3813855	140075	0	None	5	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	573	12	0	5	5.8	COc1ccc(CCN(CCCc2ccccc2I)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	5	139	66	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030205t
	5202	139	66	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030205t
	CHEMBL39	139	66	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030205t
	DB08839	139	66	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030205t
	152	361	18	None	1	18	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm030205t
	2107	361	18	None	1	18	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm030205t
	CHEMBL275854	361	18	None	1	18	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm030205t
	9856041	23910	2	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	230	2	2	2	2.4	CC(N)Cc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
	CHEMBL133868	23910	2	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	230	2	2	2	2.4	CC(N)Cc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
	5	139	66	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2014.02.029
	5202	139	66	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2014.02.029
	CHEMBL39	139	66	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2014.02.029
	DB08839	139	66	None	-13	54	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2014.02.029
	156013985	176601	0	None	-2	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from recombinant human 5HT2B receptor expressed in CHO cells measured after 120 mins by scintillation counter methodDisplacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from recombinant human 5HT2B receptor expressed in CHO cells measured after 120 mins by scintillation counter method	ChEMBL	230	0	1	2	1.8	C1=CC2CNCCN3C[C@@H]4CCC[C@@H]4C(=C1)C23	10.1016/j.bmcl.2019.126929
	CHEMBL4634785	176601	0	None	-2	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from recombinant human 5HT2B receptor expressed in CHO cells measured after 120 mins by scintillation counter methodDisplacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from recombinant human 5HT2B receptor expressed in CHO cells measured after 120 mins by scintillation counter method	ChEMBL	230	0	1	2	1.8	C1=CC2CNCCN3C[C@@H]4CCC[C@@H]4C(=C1)C23	10.1016/j.bmcl.2019.126929
	45486824	195701	0	None	-14	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	421	4	3	4	3.3	O=C1Cc2c(ccc3c2OC[C@H](CNCC2CCc4[nH]c5ccc(F)cc5c4C2)O3)N1	10.1016/j.bmcl.2009.08.050
	CHEMBL569251	195701	0	None	-14	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	421	4	3	4	3.3	O=C1Cc2c(ccc3c2OC[C@H](CNCC2CCc4[nH]c5ccc(F)cc5c4C2)O3)N1	10.1016/j.bmcl.2009.08.050
	CHEMBL5094234	213797	0	None	-61	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5096019	213797	0	None	-61	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5090884	213801	0	None	-1	7	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5096072	213801	0	None	-1	7	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	24771120	183518	0	None	-56	4	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5HT2b receptorBinding affinity to 5HT2b receptor	ChEMBL	434	4	2	6	3.4	O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCNCC1	10.1016/j.bmcl.2009.03.071
	CHEMBL482562	183518	0	None	-56	4	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5HT2b receptorBinding affinity to 5HT2b receptor	ChEMBL	434	4	2	6	3.4	O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCNCC1	10.1016/j.bmcl.2009.03.071
	136020618	163362	0	None	12	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	CHEMBL4207302	163362	0	None	12	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	135753074	190514	7	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5-HT2B receptor (unknown origin) assessed as displacement of radioligand at 10 uM by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) assessed as displacement of radioligand at 10 uM by radioligand binding assay	ChEMBL	341	4	2	5	2.2	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2ccccc2F)n1	10.1021/acs.jmedchem.1c01759
	CHEMBL5187824	190514	7	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5-HT2B receptor (unknown origin) assessed as displacement of radioligand at 10 uM by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) assessed as displacement of radioligand at 10 uM by radioligand binding assay	ChEMBL	341	4	2	5	2.2	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2ccccc2F)n1	10.1021/acs.jmedchem.1c01759
	136030693	57022	1	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	222	2	2	4	0.7	NC(=O)C1CSC(c2ccccc2O)=N1	10.1021/acs.jnatprod.7b00317
	CHEMBL1651092	57022	1	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	222	2	2	4	0.7	NC(=O)C1CSC(c2ccccc2O)=N1	10.1021/acs.jnatprod.7b00317
	11739217	136516	0	None	-8	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	300	2	1	3	2.2	CCOc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL374660	136516	0	None	-8	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	300	2	1	3	2.2	CCOc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	16063039	155075	0	None	-147	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	333	3	1	3	3.9	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CCCNC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL404581	155075	0	None	-147	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	333	3	1	3	3.9	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CCCNC3)cc1	10.1016/j.bmcl.2008.01.090
	1353	1880	85	None	-295	85	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	3559	1880	85	None	-295	85	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	86	1880	85	None	-295	85	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	CHEMBL54	1880	85	None	-295	85	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	DB00502	1880	85	None	-295	85	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	CHEMBL4537673	212236	24	None	-	1	Human	5.9	pKi	=	5.9	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000305b HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000305b HTR2B	ChEMBL		None	None	None		C[C@H](c1ccnc(Nc2nc3ccc(-c4cc(N(C)C)ncn4)cc3[nH]2)c1)N1CCN(C(=O)CC(F)(F)F)CC1	nan
	44409332	76377	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	261	3	1	4	1.9	CCO[C@H](C)c1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
	CHEMBL206618	76377	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	261	3	1	4	1.9	CCO[C@H](C)c1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
	162661262	181270	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	432	6	4	7	2.7	OC[C@@]12C[C@@H]1[C@@H](n1ccc3c(NC(C4CCC4)C4CCC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1016/j.bmcl.2020.127599
	CHEMBL4778636	181270	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	432	6	4	7	2.7	OC[C@@]12C[C@@H]1[C@@H](n1ccc3c(NC(C4CCC4)C4CCC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1016/j.bmcl.2020.127599
	1016	3690	75	None	-17	35	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	2561	3690	75	None	-17	35	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	2733526	3690	75	None	-17	35	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	5384	3690	75	None	-17	35	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	CHEMBL83	3690	75	None	-17	35	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	DB00675	3690	75	None	-17	35	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	71061585	159950	0	None	3	2	Mouse	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	367	6	0	5	2.8	Cc1ccnc(C)c1OC[C@H]1CN(CCN2CCc3ccccc32)CCO1	nan
	CHEMBL4112090	159950	0	None	3	2	Mouse	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	367	6	0	5	2.8	Cc1ccnc(C)c1OC[C@H]1CN(CCN2CCc3ccccc32)CCO1	nan
	CHEMBL1909069	207332	0	None	-1	3	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL		None	None	None		None	nan
	117209971	185903	1	None	-26	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4877051	185903	1	None	-26	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	1343	1858	55	None	-14	9	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
	3519	1858	55	None	-14	9	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
	522	1858	55	None	-14	9	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
	CHEMBL862	1858	55	None	-14	9	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
	DB01018	1858	55	None	-14	9	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
	CHEMBL4780458	212287	0	None	-5	4	Human	5.9	pKi	=	5.9	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000540a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000540a HTR2B	ChEMBL		None	None	None		O=C(Nc1cccnn1)N1CC(C/C=C/c2cncc(Oc3ccc(C(F)(F)F)cn3)n2)C1	nan
	58911681	90554	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@@H]1CN2C(=O)c3ccccc3C[C@@H]2CN1	10.1016/j.bmcl.2013.04.061
	CHEMBL2396668	90554	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@@H]1CN2C(=O)c3ccccc3C[C@@H]2CN1	10.1016/j.bmcl.2013.04.061
	136118639	75964	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	335	1	2	3	3.1	CSC1=NC(=O)/C(=C/c2c[nH]c3ccc(Br)cc23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2058699	75964	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	335	1	2	3	3.1	CSC1=NC(=O)/C(=C/c2c[nH]c3ccc(Br)cc23)N1	10.1016/j.bmc.2013.09.011
	2337	3205	72	None	-15	62	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	50	3205	72	None	-15	62	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	5002	3205	72	None	-15	62	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	CHEMBL716	3205	72	None	-15	62	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	DB01224	3205	72	None	-15	62	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	71455625	82551	0	None	-3388	6	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	353	5	0	4	4.4	CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1	10.1021/jm300943r
	CHEMBL2181170	82551	0	None	-3388	6	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	353	5	0	4	4.4	CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1	10.1021/jm300943r
	44407398	74069	0	None	-8	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	365	5	1	3	5.5	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccc2ccccc2c1	10.1016/j.bmcl.2005.10.029
	CHEMBL202616	74069	0	None	-8	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	365	5	1	3	5.5	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccc2ccccc2c1	10.1016/j.bmcl.2005.10.029
	136030596	57020	1	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	209	2	2	4	1.2	OC[C@@H]1CSC(c2ccccc2O)=N1	10.1021/np100588c
	CHEMBL1651090	57020	1	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	209	2	2	4	1.2	OC[C@@H]1CSC(c2ccccc2O)=N1	10.1021/np100588c
	168277287	189557	0	None	3	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assayDisplacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assay	ChEMBL	426	7	2	3	7.8	CCCC(CCC)c1nc2c(Nc3ccc(Cl)c(Cl)c3)nc3ccccc3c2[nH]1	10.1021/acs.jmedchem.2c01170
	CHEMBL5173661	189557	0	None	3	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assayDisplacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assay	ChEMBL	426	7	2	3	7.8	CCCC(CCC)c1nc2c(Nc3ccc(Cl)c(Cl)c3)nc3ccccc3c2[nH]1	10.1021/acs.jmedchem.2c01170
	25123011	199508	0	None	-74	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	406	3	2	5	3.5	NC1CCN(c2ccc3[nH]nc(S(=O)(=O)c4ccc5ccccc5c4)c3c2)CC1	10.1021/jm901674f
	CHEMBL603483	199508	0	None	-74	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	406	3	2	5	3.5	NC1CCN(c2ccc3[nH]nc(S(=O)(=O)c4ccc5ccccc5c4)c3c2)CC1	10.1021/jm901674f
	46230046	197567	0	None	14	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	203	0	2	3	0.2	O=C1NC2CNCCN2c2ccccc21	10.1016/j.bmcl.2009.12.014
	CHEMBL590077	197567	0	None	14	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	203	0	2	3	0.2	O=C1NC2CNCCN2c2ccccc21	10.1016/j.bmcl.2009.12.014
	135846958	75892	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2cc(Br)ccc12	10.1016/j.bmc.2013.09.011
	CHEMBL2058408	75892	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2cc(Br)ccc12	10.1016/j.bmc.2013.09.011
	18715555	74026	0	None	-8	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	359	5	1	5	4.1	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2005.10.029
	CHEMBL202458	74026	0	None	-8	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	359	5	1	5	4.1	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2005.10.029
	168286940	191683	0	None	-691	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor at 25 uM incubated for 1 hr by microbeta2 beta-counter analysisDisplacement of [3H]-LSD from human 5-HT2B receptor at 25 uM incubated for 1 hr by microbeta2 beta-counter analysis	ChEMBL	454	7	1	4	4.0	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCC(F)(F)F)cc2)CC1	10.1016/j.ejmech.2022.114246
	CHEMBL5205903	191683	0	None	-691	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor at 25 uM incubated for 1 hr by microbeta2 beta-counter analysisDisplacement of [3H]-LSD from human 5-HT2B receptor at 25 uM incubated for 1 hr by microbeta2 beta-counter analysis	ChEMBL	454	7	1	4	4.0	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCC(F)(F)F)cc2)CC1	10.1016/j.ejmech.2022.114246
	76518514	113038	0	None	-147	9	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	387	6	1	2	5.3	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
	CHEMBL3321788	113038	0	None	-147	9	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	387	6	1	2	5.3	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
	58911582	90668	0	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	232	1	1	3	0.7	COc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397894	90668	0	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	232	1	1	3	0.7	COc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	59012632	87310	0	None	91	2	Human	7.9	pKi	=	7.9	Binding	Agonist activity at 5-HT2B receptor (unknown origin)Agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	388	2	1	3	4.6	COc1ccc(-c2cc3c4c(c2)[C@@H]2CNCC[C@@H]2N4CCC3)c(C(F)(F)F)c1	10.1016/j.bmcl.2012.10.091
	CHEMBL2337102	87310	0	None	91	2	Human	7.9	pKi	=	7.9	Binding	Agonist activity at 5-HT2B receptor (unknown origin)Agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	388	2	1	3	4.6	COc1ccc(-c2cc3c4c(c2)[C@@H]2CNCC[C@@H]2N4CCC3)c(C(F)(F)F)c1	10.1016/j.bmcl.2012.10.091
	127051482	140123	0	None	8	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	465	12	0	5	5.3	COc1ccc(CCN(CCCc2ccc(F)cc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3814737	140123	0	None	8	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	465	12	0	5	5.3	COc1ccc(CCN(CCCc2ccc(F)cc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	127050282	140142	0	None	7	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	525	12	0	5	5.9	COc1ccc(CCN(CCCc2cccc(Br)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3815066	140142	0	None	7	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	525	12	0	5	5.9	COc1ccc(CCN(CCCc2cccc(Br)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	10353268	97321	1	None	-2	4	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	216	2	2	2	2.0	NCCc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
	CHEMBL27173	97321	1	None	-2	4	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	216	2	2	2	2.0	NCCc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
	24893978	995	5	None	-35	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity at 5HT2B receptorBinding affinity at 5HT2B receptor	ChEMBL	525	6	2	4	4.9	Brc1cc(ccc1OC1CCNCC1)CN1CC[C@@H](C1)NC(=O)c1ccc(c(c1)Cl)Cl	10.1016/j.bmcl.2008.06.019
	8872	995	5	None	-35	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity at 5HT2B receptorBinding affinity at 5HT2B receptor	ChEMBL	525	6	2	4	4.9	Brc1cc(ccc1OC1CCNCC1)CN1CC[C@@H](C1)NC(=O)c1ccc(c(c1)Cl)Cl	10.1016/j.bmcl.2008.06.019
	CHEMBL495075	995	5	None	-35	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity at 5HT2B receptorBinding affinity at 5HT2B receptor	ChEMBL	525	6	2	4	4.9	Brc1cc(ccc1OC1CCNCC1)CN1CC[C@@H](C1)NC(=O)c1ccc(c(c1)Cl)Cl	10.1016/j.bmcl.2008.06.019
	10176869	165474	0	None	-4	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	222	0	1	2	2.0	Cc1c(Cl)ccc2c1N1CCNC[C@@H]1C2	10.1016/j.bmcl.2005.05.074
	CHEMBL425545	165474	0	None	-4	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	222	0	1	2	2.0	Cc1c(Cl)ccc2c1N1CCNC[C@@H]1C2	10.1016/j.bmcl.2005.05.074
	11595191	88631	0	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337488	88631	0	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2364960	88631	0	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	145978819	163329	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	213	2	1	4	2.0	C[C@@H]1SC(c2cccs2)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	CHEMBL4206939	163329	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	213	2	1	4	2.0	C[C@@H]1SC(c2cccs2)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	145975226	163381	0	None	-2	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	388	6	3	7	1.3	COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1N=C(c2ccccc2O)S[C@@H]1C	10.1021/acs.jnatprod.7b00317
	CHEMBL4207529	163381	0	None	-2	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	388	6	3	7	1.3	COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1N=C(c2ccccc2O)S[C@@H]1C	10.1021/acs.jnatprod.7b00317
	145976983	163454	0	None	-4	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	333	4	1	3	4.6	C[C@H]1SC(c2ccc(-c3ccccc3)cc2)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	CHEMBL4208376	163454	0	None	-4	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	333	4	1	3	4.6	C[C@H]1SC(c2ccc(-c3ccccc3)cc2)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	136030596	57020	1	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	209	2	2	4	1.2	OC[C@@H]1CSC(c2ccccc2O)=N1	10.1021/acs.jnatprod.7b00317
	CHEMBL1651090	57020	1	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	209	2	2	4	1.2	OC[C@@H]1CSC(c2ccccc2O)=N1	10.1021/acs.jnatprod.7b00317
	44537940	18587	0	None	-18	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	482	5	1	6	4.5	O=S(=O)(c1cccc2ccccc12)c1nn(Cc2ccccc2)c2ccc(N3CCNCC3)cc12	10.1021/jm1007825
	CHEMBL1278001	18587	0	None	-18	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	482	5	1	6	4.5	O=S(=O)(c1cccc2ccccc12)c1nn(Cc2ccccc2)c2ccc(N3CCNCC3)cc12	10.1021/jm1007825
	16115513	135879	0	None	-23	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	252	1	1	3	1.4	COc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL373531	135879	0	None	-23	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	252	1	1	3	1.4	COc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	136118732	75893	0	None	-1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2c(Br)cccc12	10.1016/j.bmc.2013.09.011
	CHEMBL2058409	75893	0	None	-1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2c(Br)cccc12	10.1016/j.bmc.2013.09.011
	122187383	122514	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	455	5	0	5	5.6	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(CC1CC1)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	CHEMBL3609148	122514	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	455	5	0	5	5.6	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(CC1CC1)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	72549033	110204	0	None	-660	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-R-O-DOI from human 5-HT2B receptor expressed in CHO-K1 cells by by liquid scintillation spectrometryDisplacement of [125I]-R-O-DOI from human 5-HT2B receptor expressed in CHO-K1 cells by by liquid scintillation spectrometry	ChEMBL	367	3	0	5	3.3	CN1CCC(c2cccc3cc(S(=O)(=O)c4ccccn4)cnc23)CC1	10.1021/ml500045k
	CHEMBL3260311	110204	0	None	-660	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-R-O-DOI from human 5-HT2B receptor expressed in CHO-K1 cells by by liquid scintillation spectrometryDisplacement of [125I]-R-O-DOI from human 5-HT2B receptor expressed in CHO-K1 cells by by liquid scintillation spectrometry	ChEMBL	367	3	0	5	3.3	CN1CCC(c2cccc3cc(S(=O)(=O)c4ccccn4)cnc23)CC1	10.1021/ml500045k
	155536080	171548	0	None	2	10	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	2	1	2	2.9	CC[C@H]1c2cc(OC)ccc2CC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	CHEMBL4472703	171548	0	None	2	10	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	2	1	2	2.9	CC[C@H]1c2cc(OC)ccc2CC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	142601333	185181	0	None	-63	6	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4866412	185181	0	None	-63	6	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	71062646	149011	0	None	-2398	13	Mouse	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	338	6	0	4	2.8	c1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cc1	nan
	CHEMBL3946661	149011	0	None	-2398	13	Mouse	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	338	6	0	4	2.8	c1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cc1	nan
	56675412	65335	0	None	6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	334	6	0	3	4.2	c1ccc(CCCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
	CHEMBL1834255	65335	0	None	6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	334	6	0	3	4.2	c1ccc(CCCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
	134141050	146771	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	419	6	4	8	1.4	O=C(O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3928983	146771	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	419	6	4	8	1.4	O=C(O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	21302483	87311	0	None	10	2	Human	7.8	pKi	=	7.8	Binding	Agonist activity at 5-HT2B receptor (unknown origin)Agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	246	0	1	3	2.4	c1cc2c3c(c1)[C@@H]1CNCC[C@@H]1N3CCCS2	10.1016/j.bmcl.2012.10.091
	CHEMBL2337103	87311	0	None	10	2	Human	7.8	pKi	=	7.8	Binding	Agonist activity at 5-HT2B receptor (unknown origin)Agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	246	0	1	3	2.4	c1cc2c3c(c1)[C@@H]1CNCC[C@@H]1N3CCCS2	10.1016/j.bmcl.2012.10.091
	CHEMBL5094680	213734	0	None	3	8	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCCCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	46914487	15236	0	None	144	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	336	5	0	4	3.8	COc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
	CHEMBL1214830	15236	0	None	144	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	336	5	0	4	3.8	COc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
	71461603	78129	1	None	-7	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	188	0	1	2	1.4	C[C@@H]1CNC[C@H]2Cc3ccccc3N12	10.1016/j.bmcl.2005.05.074
	CHEMBL2112055	78129	1	None	-7	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	188	0	1	2	1.4	C[C@@H]1CNC[C@H]2Cc3ccccc3N12	10.1016/j.bmcl.2005.05.074
	2585	790	100	None	-18	22	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	522	790	100	None	-18	22	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	551	790	100	None	-18	22	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	CHEMBL723	790	100	None	-18	22	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	DB01136	790	100	None	-18	22	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	2389	3279	114	None	-63	67	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	5073	3279	114	None	-63	67	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	96	3279	114	None	-63	67	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	CHEMBL85	3279	114	None	-63	67	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	DB00734	3279	114	None	-63	67	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	135520431	72264	9	None	-1	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	177	2	2	4	0.7	NCCn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL199385	72264	9	None	-1	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	177	2	2	4	0.7	NCCn1ncc2ccc(O)cc21	10.1021/jm050663x
	24873257	179676	0	None	10	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	289	2	1	3	3.2	c1ccc(-c2c3c(nn2-c2ccccc2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4750414	179676	0	None	10	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	289	2	1	3	3.2	c1ccc(-c2c3c(nn2-c2ccccc2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	168274008	189602	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	397	7	0	5	4.6	CCCCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	CHEMBL5174366	189602	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	397	7	0	5	4.6	CCCCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	134143752	150116	0	None	3	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	447	7	3	9	1.9	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3955519	150116	0	None	3	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	447	7	3	9	1.9	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	134143752	150116	0	None	3	5	Human	7.8	pKi	=	7.8	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	447	7	3	9	1.9	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	CHEMBL3955519	150116	0	None	3	5	Human	7.8	pKi	=	7.8	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	447	7	3	9	1.9	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	10550406	31737	0	None	-3	3	Human	7.8	pKi	=	7.8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	427	3	1	3	5.7	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3C)c1)CC2	10.1021/jm990388c
	CHEMBL14076	31737	0	None	-3	3	Human	7.8	pKi	=	7.8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	427	3	1	3	5.7	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3C)c1)CC2	10.1021/jm990388c
	10718089	98104	0	None	-31	3	Human	7.8	pKi	=	7.8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	443	4	1	4	5.4	COc1ccc(NC(=O)N2CCc3cc(OC)c(C(F)(F)F)cc32)cc1-c1cccnc1	10.1021/jm990388c
	CHEMBL276571	98104	0	None	-31	3	Human	7.8	pKi	=	7.8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	443	4	1	4	5.4	COc1ccc(NC(=O)N2CCc3cc(OC)c(C(F)(F)F)cc32)cc1-c1cccnc1	10.1021/jm990388c
	10767350	98585	0	None	-6	3	Human	7.8	pKi	=	7.8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	489	4	1	3	7.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(-c3ccccc3)cc(-c3cccnc3)c1)CC2	10.1021/jm990388c
	CHEMBL280297	98585	0	None	-6	3	Human	7.8	pKi	=	7.8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	489	4	1	3	7.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(-c3ccccc3)cc(-c3cccnc3)c1)CC2	10.1021/jm990388c
	18475610	195121	0	None	3	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	327	3	2	3	4.5	COc1ccc(NC(=O)Nc2ccnc3ccccc23)cc1Cl	10.1016/s0960-894x(01)00343-2
	CHEMBL56557	195121	0	None	3	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	327	3	2	3	4.5	COc1ccc(NC(=O)Nc2ccnc3ccccc23)cc1Cl	10.1016/s0960-894x(01)00343-2
	10714852	162600	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	381	4	1	3	5.2	CCCSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
	CHEMBL41792	162600	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	381	4	1	3	5.2	CCCSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
	44298082	193294	0	None	-3	3	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	442	4	1	4	5.3	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ncccc3C)nc1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL54484	193294	0	None	-3	3	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	442	4	1	4	5.3	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ncccc3C)nc1)CC2	10.1016/s0960-894x(00)00365-6
	118055289	177325	0	None	-19	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	236	0	1	2	2.7	Cc1cc2c3c(c1Cl)C(C)CN3CCNC2	10.1016/j.bmcl.2019.126929
	CHEMBL4644872	177325	0	None	-19	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	236	0	1	2	2.7	Cc1cc2c3c(c1Cl)C(C)CN3CCNC2	10.1016/j.bmcl.2019.126929
	10421236	188147	1	None	4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation counting	ChEMBL	226	1	3	4	1.9	Nc1nccc(-c2c[nH]c3cccc(O)c23)n1	10.1016/j.bmc.2011.08.033
	CHEMBL50498	188147	1	None	4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation counting	ChEMBL	226	1	3	4	1.9	Nc1nccc(-c2c[nH]c3cccc(O)c23)n1	10.1016/j.bmc.2011.08.033
	135367857	164052	0	None	-9	8	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4215875	164052	0	None	-9	8	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	145967795	164271	0	None	5	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	213	2	1	4	2.0	C[C@@H]1SC(c2ccsc2)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	CHEMBL4218679	164271	0	None	5	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	213	2	1	4	2.0	C[C@@H]1SC(c2ccsc2)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	136259032	164088	16	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	205	2	1	4	2.3	O=Cc1csc(-c2ccccc2O)n1	10.1021/acs.jnatprod.7b00317
	CHEMBL4216337	164088	16	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	205	2	1	4	2.3	O=Cc1csc(-c2ccccc2O)n1	10.1021/acs.jnatprod.7b00317
	732268	137768	28	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	257	1	3	5	2.0	NC1=NC2(CCCCC2)NC(Nc2ccccc2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL3770837	137768	28	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	257	1	3	5	2.0	NC1=NC2(CCCCC2)NC(Nc2ccccc2)=N1	10.1021/acsmedchemlett.8b00300
	127051843	140220	0	None	-6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	0	3	3.6	N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818200	140220	0	None	-6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	0	3	3.6	N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	1222	1634	44	None	-52	32	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm100600y
	3396	1634	44	None	-52	32	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm100600y
	85	1634	44	None	-52	32	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm100600y
	CHEMBL46516	1634	44	None	-52	32	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm100600y
	DB04842	1634	44	None	-52	32	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm100600y
	2801	161325	56	None	-3	28	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	0	2	4.5	CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21	nan
	CHEMBL1200710	161325	56	None	-3	28	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	0	2	4.5	CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21	nan
	CHEMBL415	161325	56	None	-3	28	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	0	2	4.5	CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21	nan
	127051843	140220	0	None	-6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	0	3	3.6	N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818200	140220	0	None	-6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	0	3	3.6	N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	155543832	172640	0	None	-134	7	Human	5.8	pKi	=	5.8	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	451	6	3	7	3.4	O[C@H]1[C@H](n2cnc3c(NC(C4CCC4)C4CCC4)nc(Cl)nc32)[C@H]2C[C@@]2(CCl)[C@H]1O	10.1021/acs.jmedchem.8b01662
	CHEMBL4522864	172640	0	None	-134	7	Human	5.8	pKi	=	5.8	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	451	6	3	7	3.4	O[C@H]1[C@H](n2cnc3c(NC(C4CCC4)C4CCC4)nc(Cl)nc32)[C@H]2C[C@@]2(CCl)[C@H]1O	10.1021/acs.jmedchem.8b01662
	11952353	198178	0	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]DOI from human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from human 5HT2B receptor expressed in CHO cells	ChEMBL	345	4	1	4	3.0	Fc1ccc(F)c(CO[C@H]2CCc3ccc(N4CCNCC4)nc32)c1	10.1016/j.bmcl.2009.10.112
	CHEMBL594469	198178	0	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]DOI from human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from human 5HT2B receptor expressed in CHO cells	ChEMBL	345	4	1	4	3.0	Fc1ccc(F)c(CO[C@H]2CCc3ccc(N4CCNCC4)nc32)c1	10.1016/j.bmcl.2009.10.112
	168274751	190044	0	None	2	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	369	5	0	5	3.9	CCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	CHEMBL5181312	190044	0	None	2	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	369	5	0	5	3.9	CCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	11302765	83832	2	None	-7	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	284	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL221113	83832	2	None	-7	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	284	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	10235	2636	1	None	-61	6	Human	6.8	pKi	=	6.8	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	433	6	4	8	2.1	OC[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC(C1CCC1)C1CCC1	10.1021/acs.jmedchem.8b01662
	137553161	2636	1	None	-61	6	Human	6.8	pKi	=	6.8	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	433	6	4	8	2.1	OC[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC(C1CCC1)C1CCC1	10.1021/acs.jmedchem.8b01662
	CHEMBL4470080	2636	1	None	-61	6	Human	6.8	pKi	=	6.8	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	433	6	4	8	2.1	OC[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC(C1CCC1)C1CCC1	10.1021/acs.jmedchem.8b01662
	CHEMBL4545807	212241	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000748a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000748a HTR2B	ChEMBL		None	None	None		Cn1c(-c2csc(C3CCN(CC4=NC5N=CC=CC5N4)CC3)n2)nc2ccccc21	nan
	56645363	120976	7	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000313b HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000313b HTR2B	ChEMBL	311	3	1	4	3.8	CC(C)(O)c1cncc(-c2nc3ccc(F)cc3n2C2CC2)c1	nan
	CHEMBL3582478	120976	7	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000313b HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000313b HTR2B	ChEMBL	311	3	1	4	3.8	CC(C)(O)c1cncc(-c2nc3ccc(F)cc3n2C2CC2)c1	nan
	136118650	75970	0	None	6	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.0	C/N=C1\NC(=O)/C(=C/c2c[nH]c3cc(Br)ccc23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2058705	75970	0	None	6	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.0	C/N=C1\NC(=O)/C(=C/c2c[nH]c3cc(Br)ccc23)N1	10.1016/j.bmc.2013.09.011
	44581972	175027	0	None	-5	10	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	499	6	2	6	4.3	O=C(Nc1cccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)c1)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
	CHEMBL458001	175027	0	None	-5	10	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	499	6	2	6	4.3	O=C(Nc1cccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)c1)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
	136020620	57026	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	219	2	1	4	2.6	Cc1sc(-c2ccccc2O)nc1C=O	10.1021/np100588c
	CHEMBL1651096	57026	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	219	2	1	4	2.6	Cc1sc(-c2ccccc2O)nc1C=O	10.1021/np100588c
	142601325	185287	0	None	-3	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4868035	185287	0	None	-3	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	16117151	59771	0	None	-154	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	390	4	3	5	3.2	O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
	CHEMBL1642882	59771	0	None	-154	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	390	4	3	5	3.2	O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
	CHEMBL1739102	59771	0	None	-154	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	390	4	3	5	3.2	O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
	25263297	183755	0	None	-19	4	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2b receptorBinding affinity to 5HT2b receptor	ChEMBL	394	5	2	6	2.7	NCCC(=O)Nc1cccc2c1cnn2S(=O)(=O)c1cccc2ccccc12	10.1016/j.bmcl.2009.03.071
	CHEMBL484345	183755	0	None	-19	4	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2b receptorBinding affinity to 5HT2b receptor	ChEMBL	394	5	2	6	2.7	NCCC(=O)Nc1cccc2c1cnn2S(=O)(=O)c1cccc2ccccc12	10.1016/j.bmcl.2009.03.071
	53483975	65283	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	364	7	0	4	4.2	COc1ccc(CCCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
	CHEMBL1833977	65283	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	364	7	0	4	4.2	COc1ccc(CCCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
	1605	2310	110	None	-1	4	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
	3957	2310	110	None	-1	4	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
	7216	2310	110	None	-1	4	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
	CHEMBL998	2310	110	None	-1	4	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
	DB00455	2310	110	None	-1	4	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
	168282554	190272	0	None	1	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	383	5	0	5	4.3	COc1cc2c(cc1OC)-c1c(OC)c(OC(C)C)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL5184659	190272	0	None	1	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	383	5	0	5	4.3	COc1cc2c(cc1OC)-c1c(OC)c(OC(C)C)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	155530292	170928	0	None	-3548	7	Human	5.8	pKi	=	5.8	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	458	5	4	8	1.6	O=C(NC1CC1)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@H]4C[C@H]5CC[C@@H]4C5)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	CHEMBL4463802	170928	0	None	-3548	7	Human	5.8	pKi	=	5.8	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	458	5	4	8	1.6	O=C(NC1CC1)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@H]4C[C@H]5CC[C@@H]4C5)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	10151289	133060	0	None	-6	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	434	6	0	4	4.7	O=C1N(c2ccc(OCCN3CCCCC3)nc2)CCN1c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2005.08.004
	CHEMBL371211	133060	0	None	-6	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	434	6	0	4	4.7	O=C1N(c2ccc(OCCN3CCCCC3)nc2)CCN1c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2005.08.004
	49850872	56164	0	None	-630	9	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	388	5	1	4	3.9	CC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
	CHEMBL1632206	56164	0	None	-630	9	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	388	5	1	4	3.9	CC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
	10830245	100954	0	None	-7	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	329	1	1	2	4.6	CC(C)(C)c1cc2c(cc1Cl)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
	CHEMBL297445	100954	0	None	-7	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	329	1	1	2	4.6	CC(C)(C)c1cc2c(cc1Cl)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
	10408409	192560	0	None	-79	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	395	3	1	5	4.5	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cccnc3C)nn1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL52308	192560	0	None	-79	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	395	3	1	5	4.5	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cccnc3C)nn1)CC2	10.1016/s0960-894x(00)00364-4
	44298226	194811	0	None	-100	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	378	3	1	4	4.6	Cc1cc2c(cc1F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL56336	194811	0	None	-100	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	378	3	1	4	4.6	Cc1cc2c(cc1F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	153287542	168967	0	None	-6	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	265	1	1	2	3.6	C[C@@]12COc3c(-c4ccccc4)cccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	CHEMBL4435237	168967	0	None	-6	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	265	1	1	2	3.6	C[C@@]12COc3c(-c4ccccc4)cccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	11237290	87529	0	None	-199	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	458	6	0	4	4.7	COc1ccc(N2Cc3cccc(Br)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	CHEMBL234109	87529	0	None	-199	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	458	6	0	4	4.7	COc1ccc(N2Cc3cccc(Br)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	10413268	152135	0	None	-31	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	453	6	0	5	4.9	COc1ccc(N2Cc3c(c4ccc(Cl)cc4n3C)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.10.034
	CHEMBL397259	152135	0	None	-31	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	453	6	0	5	4.9	COc1ccc(N2Cc3c(c4ccc(Cl)cc4n3C)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.10.034
	44420682	137083	0	None	-3	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	0	2	2.1	CN1CCN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2C1	10.1021/jm0612968
	CHEMBL375642	137083	0	None	-3	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	0	2	2.1	CN1CCN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2C1	10.1021/jm0612968
	162647275	178982	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	294	4	1	3	4.0	Cc1ccc(CCCc2cc(=O)c3c(O)cccc3o2)cc1	10.1016/j.bmcl.2020.127511
	CHEMBL4741776	178982	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	294	4	1	3	4.0	Cc1ccc(CCCc2cc(=O)c3c(O)cccc3o2)cc1	10.1016/j.bmcl.2020.127511
	10150393	71565	0	None	-398	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	373	7	0	4	3.2	COc1ccc(N2CCN(c3cccc(F)c3)C2=O)cc1OCCN(C)C	10.1016/j.bmcl.2005.08.004
	CHEMBL197170	71565	0	None	-398	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	373	7	0	4	3.2	COc1ccc(N2CCN(c3cccc(F)c3)C2=O)cc1OCCN(C)C	10.1016/j.bmcl.2005.08.004
	10479309	79337	0	None	-79	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	458	8	0	5	4.7	COc1ccc(N2CCC(c3ccc(OC)c(OCCN4CCCCC4)c3)C2=O)cc1Cl	10.1016/j.bmcl.2006.05.034
	CHEMBL211719	79337	0	None	-79	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	458	8	0	5	4.7	COc1ccc(N2CCC(c3ccc(OC)c(OCCN4CCCCC4)c3)C2=O)cc1Cl	10.1016/j.bmcl.2006.05.034
	44414217	79733	0	None	-1	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	516	7	0	4	6.3	O=C1C(c2ccc(Cl)c(Cl)c2)CCN1c1ccc(OC(F)(F)F)c(OCCN2CCCCC2)c1	10.1016/j.bmcl.2006.05.034
	CHEMBL213368	79733	0	None	-1	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	516	7	0	4	6.3	O=C1C(c2ccc(Cl)c(Cl)c2)CCN1c1ccc(OC(F)(F)F)c(OCCN2CCCCC2)c1	10.1016/j.bmcl.2006.05.034
	24887284	141214	0	None	-125	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	462	7	0	4	5.4	COc1ccc(N2CCC(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	CHEMBL385921	141214	0	None	-125	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	462	7	0	4	5.4	COc1ccc(N2CCC(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	24888183	141287	0	None	-1000	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	420	7	0	4	4.5	COc1ccc(N2CC=C(c3ccc(C)cc3)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.05.034
	CHEMBL386332	141287	0	None	-1000	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	420	7	0	4	4.5	COc1ccc(N2CC=C(c3ccc(C)cc3)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.05.034
	10296414	3475	11	None	-1258	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1016/j.bmcl.2006.11.031
	76	3475	11	None	-1258	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1016/j.bmcl.2006.11.031
	CHEMBL183460	3475	11	None	-1258	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1016/j.bmcl.2006.11.031
	11248705	89864	0	None	-630	10	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
	CHEMBL238519	89864	0	None	-630	10	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
	91826739	121499	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	282	4	1	4	3.2	O=c1cc(COCc2ccccc2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
	CHEMBL3593952	121499	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	282	4	1	4	3.2	O=c1cc(COCc2ccccc2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
	168271856	189967	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	381	6	0	5	4.0	C=CCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	CHEMBL5180016	189967	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	381	6	0	5	4.0	C=CCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	44572166	12354	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl	10.1021/jm801354e
	CHEMBL1186133	12354	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl	10.1021/jm801354e
	CHEMBL451232	12354	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl	10.1021/jm801354e
	44572751	12393	1	None	4	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
	CHEMBL1186509	12393	1	None	4	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
	CHEMBL467736	12393	1	None	4	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
	127026052	137028	0	None	4	19	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	258	7	1	1	3.5	C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12	10.1016/j.bmcl.2015.12.053
	CHEMBL3754496	137028	0	None	4	19	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	258	7	1	1	3.5	C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12	10.1016/j.bmcl.2015.12.053
	145989551	166585	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	297	3	0	2	4.1	CN(C)CC/C=C1\c2ccc(F)cc2COc2ccccc21	10.1021/acsmedchemlett.8b00300
	CHEMBL4290607	166585	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	297	3	0	2	4.1	CN(C)CC/C=C1\c2ccc(F)cc2COc2ccccc21	10.1021/acsmedchemlett.8b00300
	70687202	77624	0	None	-10	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	188	0	1	2	1.4	C[C@@H]1CNC[C@@H]2Cc3ccccc3N21	10.1016/j.bmcl.2005.05.074
	CHEMBL2096809	77624	0	None	-10	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	188	0	1	2	1.4	C[C@@H]1CNC[C@@H]2Cc3ccccc3N21	10.1016/j.bmcl.2005.05.074
	11231392	84470	0	None	-13	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	246	2	1	3	1.6	CC(C)Oc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	CHEMBL223628	84470	0	None	-13	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	246	2	1	3	1.6	CC(C)Oc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	11080	28872	74	None	-6	6	Human	4.8	pKi	=	4.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
	CHEMBL1381098	28872	74	None	-6	6	Human	4.8	pKi	=	4.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
	59652086	114094	0	None	-85	2	Human	5.8	pKi	=	5.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000726a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000726a HTR2B	ChEMBL	448	8	2	6	3.6	COc1cccc(CNC(=O)c2nc3scc(CN(C)Cc4ccccc4)c3c(=O)[nH]2)c1	nan
	CHEMBL3337895	114094	0	None	-85	2	Human	5.8	pKi	=	5.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000726a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000726a HTR2B	ChEMBL	448	8	2	6	3.6	COc1cccc(CNC(=O)c2nc3scc(CN(C)Cc4ccccc4)c3c(=O)[nH]2)c1	nan
	49865833	15988	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	296	1	1	3	3.2	O=C(Nc1ccccc1)N1OCC2COc3ccccc3C21	10.1016/j.bmcl.2010.07.074
	CHEMBL1224036	15988	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	296	1	1	3	3.2	O=C(Nc1ccccc1)N1OCC2COc3ccccc3C21	10.1016/j.bmcl.2010.07.074
	14702424	18377	61	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	176	2	2	2	1.6	COc1ccc2[nH]cc(CN)c2c1	10.1021/jm100600y
	CHEMBL1276050	18377	61	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	176	2	2	2	1.6	COc1ccc2[nH]cc(CN)c2c1	10.1021/jm100600y
	71462776	82550	0	None	-134	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	460	5	0	3	5.5	CCCN1CCC(COc2nc3c(I)cccc3c3ccccc23)CC1	10.1021/jm300943r
	CHEMBL2181169	82550	0	None	-134	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	460	5	0	3	5.5	CCCN1CCC(COc2nc3c(I)cccc3c3ccccc23)CC1	10.1021/jm300943r
	136118659	75902	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2058427	75902	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C	10.1016/j.bmc.2013.09.011
	21527771	69813	0	None	-645	10	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	363	6	1	3	4.2	OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	CHEMBL1940404	69813	0	None	-645	10	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	363	6	1	3	4.2	OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	134135745	143846	0	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	407	6	4	8	1.6	CC(C)[C@@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1021/acs.jmedchem.6b01183
	CHEMBL3905850	143846	0	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	407	6	4	8	1.6	CC(C)[C@@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1021/acs.jmedchem.6b01183
	134156506	153529	0	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	407	6	4	8	1.6	CC(C)[C@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1021/acs.jmedchem.6b01183
	CHEMBL3984645	153529	0	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	407	6	4	8	1.6	CC(C)[C@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1021/acs.jmedchem.6b01183
	58911666	90660	0	None	-1	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@H]1CNC[C@H]2Cc3ccccc3C(=O)N12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397886	90660	0	None	-1	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@H]1CNC[C@H]2Cc3ccccc3C(=O)N12	10.1016/j.bmcl.2013.04.061
	25120700	80827	0	None	5	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	369	7	1	5	3.0	COc1ccc(N2CCN(CC[C@@H](OC(N)=O)c3ccccc3)CC2)cc1	10.1016/j.bmcl.2012.02.023
	CHEMBL2158704	80827	0	None	5	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	369	7	1	5	3.0	COc1ccc(N2CCN(CC[C@@H](OC(N)=O)c3ccccc3)CC2)cc1	10.1016/j.bmcl.2012.02.023
	45486820	195259	0	None	-12	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	432	3	2	4	3.8	O=c1[nH]c2cccc(N3C[C@H]4C[C@@H]3CN4CC3CCc4[nH]c5ccc(F)cc5c4C3)c2o1	10.1016/j.bmcl.2009.08.050
	CHEMBL1237149	195259	0	None	-12	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	432	3	2	4	3.8	O=c1[nH]c2cccc(N3C[C@H]4C[C@@H]3CN4CC3CCc4[nH]c5ccc(F)cc5c4C3)c2o1	10.1016/j.bmcl.2009.08.050
	CHEMBL566356	195259	0	None	-12	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	432	3	2	4	3.8	O=c1[nH]c2cccc(N3C[C@H]4C[C@@H]3CN4CC3CCc4[nH]c5ccc(F)cc5c4C3)c2o1	10.1016/j.bmcl.2009.08.050
	71062768	143204	0	None	-4	4	Mouse	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	382	6	0	5	2.4	COc1cccc(OC[C@@H]2CN(CC(=O)N3CCc4ccccc43)CCO2)c1	nan
	CHEMBL3900699	143204	0	None	-4	4	Mouse	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	382	6	0	5	2.4	COc1cccc(OC[C@@H]2CN(CC(=O)N3CCc4ccccc43)CCO2)c1	nan
	3151	1434	93	None	-125	26	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
	945	1434	93	None	-125	26	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
	965	1434	93	None	-125	26	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
	CHEMBL219916	1434	93	None	-125	26	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
	DB01184	1434	93	None	-125	26	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
	44409317	140826	0	None	-7	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	267	0	1	3	1.6	C[C@@H]1CNC[C@@H]2Cc3ccc(Br)nc3N21	10.1016/j.bmcl.2005.11.083
	CHEMBL383694	140826	0	None	-7	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	267	0	1	3	1.6	C[C@@H]1CNC[C@@H]2Cc3ccc(Br)nc3N21	10.1016/j.bmcl.2005.11.083
	46884102	7979	0	None	-912	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	366	5	2	3	3.7	CC1(C)CCC(Oc2cc(F)c(CNC(=O)[C@@H]3CCCN3)cc2F)CC1	10.1016/j.bmcl.2010.01.107
	CHEMBL1091106	7979	0	None	-912	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	366	5	2	3	3.7	CC1(C)CCC(Oc2cc(F)c(CNC(=O)[C@@H]3CCCN3)cc2F)CC1	10.1016/j.bmcl.2010.01.107
	135501716	75960	0	None	1	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	321	1	3	2	2.3	O=C1NC(=S)N/C1=C\c1c[nH]c2ccc(Br)cc12	10.1016/j.bmc.2013.09.011
	CHEMBL2058695	75960	0	None	1	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	321	1	3	2	2.3	O=C1NC(=S)N/C1=C\c1c[nH]c2ccc(Br)cc12	10.1016/j.bmc.2013.09.011
	49783419	17567	0	None	-501	13	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	366	6	1	6	2.8	CCCCN1CCC(COC(=O)c2cc(F)c(N)c3c2OCCO3)CC1	10.1021/jm100668r
	CHEMBL1258671	17567	0	None	-501	13	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	366	6	1	6	2.8	CCCCN1CCC(COC(=O)c2cc(F)c(N)c3c2OCCO3)CC1	10.1021/jm100668r
	118055288	176462	0	None	-58	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	256	0	1	2	3.0	CC1CN2CCNCc3cc(Cl)c(Cl)c1c32	10.1016/j.bmcl.2019.126929
	CHEMBL4632473	176462	0	None	-58	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	256	0	1	2	3.0	CC1CN2CCNCc3cc(Cl)c(Cl)c1c32	10.1016/j.bmcl.2019.126929
	25209356	179205	0	None	-1	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	544	7	2	8	4.0	COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCNCC5)c(Cl)c4=O)c3C)cc2)cn1	10.1021/jm800962k
	CHEMBL474473	179205	0	None	-1	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	544	7	2	8	4.0	COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCNCC5)c(Cl)c4=O)c3C)cc2)cn1	10.1021/jm800962k
	127051015	140343	0	None	-63	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818128	140343	0	None	-63	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819731	140343	0	None	-63	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	24826957	90686	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	246	1	1	3	1.0	COc1ccc(C)c2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397912	90686	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	246	1	1	3	1.0	COc1ccc(C)c2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	127049983	140131	0	None	7	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	481	12	0	5	5.8	COc1ccc(CCN(CCCc2cccc(Cl)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3814821	140131	0	None	7	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	481	12	0	5	5.8	COc1ccc(CCN(CCCc2cccc(Cl)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	127037093	135985	0	None	40	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	433	11	0	5	4.8	COc1ccc(CCN(CCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3736252	135985	0	None	40	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	433	11	0	5	4.8	COc1ccc(CCN(CCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	44435193	90794	0	None	1	7	Human	6.8	pKi	=	6.8	Binding	Antagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assay	ChEMBL	331	2	0	2	5.6	CC(C(=O)N1c2ccccc2Sc2ccccc21)c1ccccc1	10.1016/j.bmcl.2013.04.082
	CHEMBL240045	90794	0	None	1	7	Human	6.8	pKi	=	6.8	Binding	Antagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assay	ChEMBL	331	2	0	2	5.6	CC(C(=O)N1c2ccccc2Sc2ccccc21)c1ccccc1	10.1016/j.bmcl.2013.04.082
	CHEMBL5083607	213101	0	None	-14	9	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL5093342	213788	0	None	-19	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095971	213788	0	None	-19	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	162647063	179068	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	499	6	4	8	1.6	CC(C)[C@@H](Nc1nc(I)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1016/j.bmcl.2020.127599
	CHEMBL4743059	179068	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	499	6	4	8	1.6	CC(C)[C@@H](Nc1nc(I)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1016/j.bmcl.2020.127599
	162646751	179162	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	419	7	4	9	1.7	CSc1nc(N[C@H](C(C)C)C2CC2)c2ncn([C@H]3[C@H](O)[C@H](O)[C@]4(CO)C[C@H]34)c2n1	10.1016/j.bmcl.2020.127599
	CHEMBL4744176	179162	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	419	7	4	9	1.7	CSc1nc(N[C@H](C(C)C)C2CC2)c2ncn([C@H]3[C@H](O)[C@H](O)[C@]4(CO)C[C@H]34)c2n1	10.1016/j.bmcl.2020.127599
	90469115	185260	2	None	-56	17	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	410	3	1	6	3.0	O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21	10.1021/acs.jmedchem.1c00224
	CHEMBL4867565	185260	2	None	-56	17	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	410	3	1	6	3.0	O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21	10.1021/acs.jmedchem.1c00224
	67978437	120165	0	None	-85	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	257	2	0	1	4.2	CN(C)[C@H]1Cc2ccccc2[C@H](C2CCCCC2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402657	120165	0	None	-85	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	257	2	0	1	4.2	CN(C)[C@H]1Cc2ccccc2[C@H](C2CCCCC2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547010	120165	0	None	-85	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	257	2	0	1	4.2	CN(C)[C@H]1Cc2ccccc2[C@H](C2CCCCC2)C1	10.1016/j.bmc.2015.01.060
	44404887	133906	0	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	340	8	2	4	3.0	CCCCn1cc(CCN(C)C)c2c(OP(=O)(O)O)cccc21	10.1016/j.bmcl.2005.06.104
	CHEMBL371753	133906	0	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	340	8	2	4	3.0	CCCCn1cc(CCN(C)C)c2c(OP(=O)(O)O)cccc21	10.1016/j.bmcl.2005.06.104
	127051015	140343	0	None	-63	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818128	140343	0	None	-63	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819731	140343	0	None	-63	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	11652359	88699	0	None	-4	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	264	1	1	2	2.0	CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1N(C)C2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337502	88699	0	None	-4	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	264	1	1	2	2.0	CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1N(C)C2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365706	88699	0	None	-4	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	264	1	1	2	2.0	CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1N(C)C2=O	10.1016/j.bmcl.2012.10.091
	45279963	80497	48	None	21	2	Human	6.8	pKi	=	6.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000717a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000717a HTR2B	ChEMBL	425	6	3	5	3.8	O=C1c2ccc(Nc3ccc(F)cc3F)cc2CCc2ccc(OC[C@H](O)CO)cc21	nan
	CHEMBL2152944	80497	48	None	21	2	Human	6.8	pKi	=	6.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000717a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000717a HTR2B	ChEMBL	425	6	3	5	3.8	O=C1c2ccc(Nc3ccc(F)cc3F)cc2CCc2ccc(OC[C@H](O)CO)cc21	nan
	46884101	7977	0	None	-87	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	310	6	2	3	2.6	O=C(NCc1ccc(OCc2ccccc2)cc1)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	CHEMBL1091104	7977	0	None	-87	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	310	6	2	3	2.6	O=C(NCc1ccc(OCc2ccccc2)cc1)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	25263302	191387	0	None	-134	5	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2b receptorBinding affinity to 5HT2b receptor	ChEMBL	434	4	2	6	3.4	O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCCNC1	10.1016/j.bmcl.2009.03.071
	CHEMBL520129	191387	0	None	-134	5	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2b receptorBinding affinity to 5HT2b receptor	ChEMBL	434	4	2	6	3.4	O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCCNC1	10.1016/j.bmcl.2009.03.071
	44409290	74302	0	None	-45	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	273	4	1	4	1.7	C[C@@H]1CNC[C@H]2Cc3ccc(COCC4CC4)nc3N12	10.1016/j.bmcl.2005.11.083
	CHEMBL203013	74302	0	None	-45	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	273	4	1	4	1.7	C[C@@H]1CNC[C@H]2Cc3ccc(COCC4CC4)nc3N12	10.1016/j.bmcl.2005.11.083
	16117279	59820	0	None	-1778	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	398	5	3	5	3.7	CC(C)c1ccc(S(=O)(=O)c2n[nH]c3ccc(NC4CCNCC4)cc23)cc1	10.1016/j.bmc.2010.10.033
	CHEMBL1642886	59820	0	None	-1778	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	398	5	3	5	3.7	CC(C)c1ccc(S(=O)(=O)c2n[nH]c3ccc(NC4CCNCC4)cc23)cc1	10.1016/j.bmc.2010.10.033
	CHEMBL1739606	59820	0	None	-1778	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	398	5	3	5	3.7	CC(C)c1ccc(S(=O)(=O)c2n[nH]c3ccc(NC4CCNCC4)cc23)cc1	10.1016/j.bmc.2010.10.033
	57799326	88679	0	None	-2	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	242	1	2	2	1.7	Cc1cc(C2CC2)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337104	88679	0	None	-2	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	242	1	2	2	1.7	Cc1cc(C2CC2)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365468	88679	0	None	-2	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	242	1	2	2	1.7	Cc1cc(C2CC2)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	145988693	166613	0	None	-7	17	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	524	7	1	3	7.1	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	CHEMBL4291048	166613	0	None	-7	17	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	524	7	1	3	7.1	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	153287572	172850	0	None	11	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	205	1	1	2	2.6	CC[C@H]1c2cc(C)ccc2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	CHEMBL4528651	172850	0	None	11	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	205	1	1	2	2.6	CC[C@H]1c2cc(C)ccc2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	49865887	16005	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	302	1	1	3	3.0	O=C(NC1CCCCC1)N1OCC2COc3ccccc3C21	10.1016/j.bmcl.2010.07.074
	CHEMBL1224103	16005	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	302	1	1	3	3.0	O=C(NC1CCCCC1)N1OCC2COc3ccccc3C21	10.1016/j.bmcl.2010.07.074
	1227	2454	35	None	-112	11	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
	2331	2454	35	None	-112	11	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
	3957	2454	35	None	-112	11	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
	4992	2454	35	None	-112	11	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
	CHEMBL511	2454	35	None	-112	11	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
	DB06691	2454	35	None	-112	11	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
	118055202	176620	0	None	-12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	236	0	1	2	2.5	CC1(C)CN2CCNCc3ccc(Cl)c1c32	10.1016/j.bmcl.2019.126929
	CHEMBL4635105	176620	0	None	-12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	236	0	1	2	2.5	CC1(C)CN2CCNCc3ccc(Cl)c1c32	10.1016/j.bmcl.2019.126929
	118055282	177440	0	None	-22	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	334	1	1	2	3.4	FC(F)(F)CC1CN2CCNCc3ccc(Br)c1c32	10.1016/j.bmcl.2019.126929
	CHEMBL4646572	177440	0	None	-22	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	334	1	1	2	3.4	FC(F)(F)CC1CN2CCNCc3ccc(Br)c1c32	10.1016/j.bmcl.2019.126929
	157	2038	5	None	-20	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm050663x
	9840090	2038	5	None	-20	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm050663x
	CHEMBL134519	2038	5	None	-20	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm050663x
	46230049	199860	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	237	0	2	3	0.8	O=C1NC2CNCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
	CHEMBL605402	199860	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	237	0	2	3	0.8	O=C1NC2CNCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
	18715564	73033	0	None	-7	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	259	2	1	3	3.2	C[C@H](N)Cn1ccc2cc(Cl)c3ncccc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL201454	73033	0	None	-7	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	259	2	1	3	3.2	C[C@H](N)Cn1ccc2cc(Cl)c3ncccc3c21	10.1016/j.bmcl.2005.10.029
	127053028	140111	0	None	8	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	573	12	0	5	5.8	COc1ccc(CCN(CCCc2cccc(I)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3814559	140111	0	None	8	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	573	12	0	5	5.8	COc1ccc(CCN(CCCc2cccc(I)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	127049982	140135	0	None	9	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	465	12	0	5	5.3	COc1ccc(CCN(CCCc2cccc(F)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3815000	140135	0	None	9	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	465	12	0	5	5.3	COc1ccc(CCN(CCCc2cccc(F)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	16115517	84414	0	None	2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	246	2	1	3	1.4	CCc1ccc2c(c1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL223468	84414	0	None	2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	246	2	1	3	1.4	CCc1ccc2c(c1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	23151712	120025	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	266	1	3	2	1.1	NC(N)=NC(=O)c1ccc2c(c1)C(N)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310120	120025	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	266	1	3	2	1.1	NC(N)=NC(=O)c1ccc2c(c1)C(N)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545471	120025	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	266	1	3	2	1.1	NC(N)=NC(=O)c1ccc2c(c1)C(N)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	157	2038	5	None	-20	4	Human	7.8	pKi	=	7.8	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm030205t
	9840090	2038	5	None	-20	4	Human	7.8	pKi	=	7.8	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm030205t
	CHEMBL134519	2038	5	None	-20	4	Human	7.8	pKi	=	7.8	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm030205t
	49862237	14838	0	None	-11	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	395	6	0	5	4.3	COc1ccc(OC)c(C2CCN(Cc3cnn(-c4ccccc4F)c3C)C2)c1	10.1016/j.bmcl.2010.06.033
	CHEMBL1209157	14838	0	None	-11	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	395	6	0	5	4.3	COc1ccc(OC)c(C2CCN(Cc3cnn(-c4ccccc4F)c3C)C2)c1	10.1016/j.bmcl.2010.06.033
	1524	2150	89	None	-218	51	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
	197	2150	89	None	-218	51	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
	3822	2150	89	None	-218	51	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
	88	2150	89	None	-218	51	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
	CHEMBL51	2150	89	None	-218	51	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
	DB12465	2150	89	None	-218	51	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
	118055199	177381	0	None	-33	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	202	0	1	2	1.9	CC1(C)CN2CCNCc3cccc1c32	10.1016/j.bmcl.2019.126929
	CHEMBL4645774	177381	0	None	-33	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	202	0	1	2	1.9	CC1(C)CN2CCNCc3cccc1c32	10.1016/j.bmcl.2019.126929
	44409124	74120	0	None	-30	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	214	0	1	4	0.7	C[C@@H]1CNC[C@H]2Cc3ccc(C#N)nc3N12	10.1016/j.bmcl.2005.11.083
	CHEMBL202795	74120	0	None	-30	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	214	0	1	4	0.7	C[C@@H]1CNC[C@H]2Cc3ccc(C#N)nc3N12	10.1016/j.bmcl.2005.11.083
	46914777	15269	0	None	18	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	382	8	0	4	4.5	FCCCOc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
	CHEMBL1215038	15269	0	None	18	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	382	8	0	4	4.5	FCCCOc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
	33630	178379	94	None	-6	27	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	CHEMBL47050	178379	94	None	-6	27	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	44582677	180991	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	432	10	1	6	3.9	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL476838	180991	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	432	10	1	6	3.9	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1	10.1016/j.bmc.2009.03.021
	71061729	160396	0	None	-1	4	Mouse	5.7	pKi	=	5.7	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	372	6	0	4	3.5	Clc1cccc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
	CHEMBL4115493	160396	0	None	-1	4	Mouse	5.7	pKi	=	5.7	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	372	6	0	4	3.5	Clc1cccc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
	25117679	198920	0	None	-8	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	406	3	1	6	3.1	Cn1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CC[C@@H](N)C3)ccc21	10.1021/jm901674f
	CHEMBL599263	198920	0	None	-8	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	406	3	1	6	3.1	Cn1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CC[C@@H](N)C3)ccc21	10.1021/jm901674f
	142601318	184963	0	None	-12	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4863036	184963	0	None	-12	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	134138183	147278	0	None	-2	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	393	6	4	8	1.4	CC[C@@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1021/acs.jmedchem.6b01183
	CHEMBL3932820	147278	0	None	-2	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	393	6	4	8	1.4	CC[C@@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1021/acs.jmedchem.6b01183
	155567457	175376	0	None	-158	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cell by radioligand binding assayDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cell by radioligand binding assay	ChEMBL	359	2	3	6	2.8	O[C@H]1CCC[C@@H]1Nc1nc(C#Cc2ccc(Cl)s2)nc2[nH]cnc12	10.1039/C8MD00317C
	CHEMBL4587951	175376	0	None	-158	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cell by radioligand binding assayDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cell by radioligand binding assay	ChEMBL	359	2	3	6	2.8	O[C@H]1CCC[C@@H]1Nc1nc(C#Cc2ccc(Cl)s2)nc2[nH]cnc12	10.1039/C8MD00317C
	46914926	15257	0	None	3	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	382	8	0	4	4.5	FCCCOc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
	CHEMBL1214960	15257	0	None	3	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	382	8	0	4	4.5	FCCCOc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
	11579853	88656	0	None	-4	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	230	1	2	2	1.4	CCc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337504	88656	0	None	-4	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	230	1	2	2	1.4	CCc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365200	88656	0	None	-4	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	230	1	2	2	1.4	CCc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	119584	2557	99	None	1	6	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
	1848	2557	99	None	1	6	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
	242	2557	99	None	1	6	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
	CHEMBL60889	2557	99	None	1	6	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
	DB11675	2557	99	None	1	6	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
	CHEMBL4750687	212278	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000312b HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000312b HTR2B	ChEMBL		None	None	None		Cc1ncc(-c2cc(Cl)ccc2F)cc1-n1c(=O)n(CC(N)=O)c2cnccc21	nan
	CHEMBL4741904	212276	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000710a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000710a HTR2B	ChEMBL		None	None	None		Cc1ncc(-c2cc(Cl)ccc2F)cc1-n1c(=O)n(CC(N)=O)c2ccccc21	nan
	44316027	203811	0	None	-12	3	Human	6.7	pKi	=	6.7	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	236	4	1	3	2.5	CCSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	CHEMBL80862	203811	0	None	-12	3	Human	6.7	pKi	=	6.7	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	236	4	1	3	2.5	CCSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	11658860	2312	47	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	2941	2312	47	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	4374	2312	47	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	CHEMBL360328	2312	47	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	DB04871	2312	47	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	CHEMBL5074880	212568	0	None	-1	9	Human	7.7	pKi	=	7.7	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	9899500	67547	0	None	-14	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	236	0	1	2	2.4	Cc1c(Cl)ccc2c1N1[C@H](CNC[C@H]1C)C2	10.1016/j.bmcl.2005.05.074
	CHEMBL191054	67547	0	None	-14	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	236	0	1	2	2.4	Cc1c(Cl)ccc2c1N1[C@H](CNC[C@H]1C)C2	10.1016/j.bmcl.2005.05.074
	11391654	179943	0	None	-2	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4753511	179943	0	None	-2	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	24873384	182019	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	255	2	1	3	2.8	CC(C)n1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4788223	182019	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	255	2	1	3	2.8	CC(C)n1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
	134154065	151829	0	None	2	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	433	6	3	9	1.5	COC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3970041	151829	0	None	2	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	433	6	3	9	1.5	COC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	11020695	25310	1	None	-5	3	Human	7.7	pKi	=	7.7	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	230	2	2	2	2.4	C[C@@H](N)Cc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
	CHEMBL135076	25310	1	None	-5	3	Human	7.7	pKi	=	7.7	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	230	2	2	2	2.4	C[C@@H](N)Cc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
	879244	27988	7	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	271	1	3	5	2.3	Cc1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acsmedchemlett.8b00300
	CHEMBL1373650	27988	7	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	271	1	3	5	2.3	Cc1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acsmedchemlett.8b00300
	10791286	35091	0	None	-9	2	Human	7.7	pKi	=	7.7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	491	3	1	3	6.1	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(Br)cc(-c3cccnc3)c1)CC2	10.1021/jm990388c
	CHEMBL14368	35091	0	None	-9	2	Human	7.7	pKi	=	7.7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	491	3	1	3	6.1	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(Br)cc(-c3cccnc3)c1)CC2	10.1021/jm990388c
	10526616	39269	0	None	-15	3	Human	7.7	pKi	=	7.7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	430	4	1	5	4.9	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3)nc1)CC2	10.1021/jm990388c
	CHEMBL14726	39269	0	None	-15	3	Human	7.7	pKi	=	7.7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	430	4	1	5	4.9	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3)nc1)CC2	10.1021/jm990388c
	44298229	101454	0	None	-31	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	428	3	1	4	5.8	Cc1cc2c(cc1Cl)N(C(=O)Nc1cnc(Oc3cccnc3C)c(Cl)c1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL301012	101454	0	None	-31	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	428	3	1	4	5.8	Cc1cc2c(cc1Cl)N(C(=O)Nc1cnc(Oc3cccnc3C)c(Cl)c1)CC2	10.1016/s0960-894x(00)00364-4
	147653864	170995	0	None	19	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	267	0	1	2	2.7	C[C@@]12COc3c(Br)cccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	CHEMBL4464697	170995	0	None	19	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	267	0	1	2	2.7	C[C@@]12COc3c(Br)cccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	153061504	172241	0	None	15	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2c(ccc3ccccc23)OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	CHEMBL4513930	172241	0	None	15	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2c(ccc3ccccc23)OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	2389	3279	114	None	-63	67	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
	5073	3279	114	None	-63	67	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
	96	3279	114	None	-63	67	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
	CHEMBL85	3279	114	None	-63	67	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
	DB00734	3279	114	None	-63	67	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
	2267	553	64	None	-10	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2017.09.020
	271	553	64	None	-10	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2017.09.020
	7121	553	64	None	-10	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2017.09.020
	CHEMBL639	553	64	None	-10	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2017.09.020
	DB00972	553	64	None	-10	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2017.09.020
	44298118	192808	0	None	-1	3	Human	7.7	pKi	=	7.7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	442	5	1	4	5.0	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCCc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL52592	192808	0	None	-1	3	Human	7.7	pKi	=	7.7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	442	5	1	4	5.0	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCCc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	12017599	194111	0	None	-6	3	Human	7.7	pKi	=	7.7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	426	4	1	3	5.2	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(CCc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL55784	194111	0	None	-6	3	Human	7.7	pKi	=	7.7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	426	4	1	3	5.2	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(CCc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	72698088	103512	0	None	-954	5	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human 5HT2BBinding affinity to human 5HT2B	ChEMBL	421	6	0	4	5.4	Fc1cccc2c1nc(OCC1CCN(CCCC(F)(F)F)CC1)c1cccnc12	10.1016/j.bmc.2013.08.061
	CHEMBL3093187	103512	0	None	-954	5	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human 5HT2BBinding affinity to human 5HT2B	ChEMBL	421	6	0	4	5.4	Fc1cccc2c1nc(OCC1CCN(CCCC(F)(F)F)CC1)c1cccnc12	10.1016/j.bmc.2013.08.061
	11175045	136018	0	None	-3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	298	1	1	2	2.9	CC(C)c1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL373695	136018	0	None	-3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	298	1	1	2	2.9	CC(C)c1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	135474338	188682	0	None	10	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3cc(Br)ccc23)C1=O	10.1016/j.bmc.2013.09.011
	CHEMBL511879	188682	0	None	10	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3cc(Br)ccc23)C1=O	10.1016/j.bmc.2013.09.011
	54761054	137553	0	None	1	2	Human	5.7	pKi	=	5.7	Binding	Positive allosteric modulation of 5-HT2B receptor (unknown origin)Positive allosteric modulation of 5-HT2B receptor (unknown origin)	ChEMBL	367	3	1	5	4.0	Cc1ccc(C(C)(C)O)cc1-c1ccc2c(n1)n(C)c(=O)n2CC(C)(C)C	10.1016/j.bmcl.2016.01.021
	CHEMBL3765778	137553	0	None	1	2	Human	5.7	pKi	=	5.7	Binding	Positive allosteric modulation of 5-HT2B receptor (unknown origin)Positive allosteric modulation of 5-HT2B receptor (unknown origin)	ChEMBL	367	3	1	5	4.0	Cc1ccc(C(C)(C)O)cc1-c1ccc2c(n1)n(C)c(=O)n2CC(C)(C)C	10.1016/j.bmcl.2016.01.021
	134149168	147714	0	None	-2	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	297	2	0	2	3.6	CN1CC[C@H]2CC(=O)[C@H](Cc3ccccc3)[C@H]3CCC[C@@H]1[C@H]23	10.1016/j.bmcl.2016.10.065
	CHEMBL3936289	147714	0	None	-2	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	297	2	0	2	3.6	CN1CC[C@H]2CC(=O)[C@H](Cc3ccccc3)[C@H]3CCC[C@@H]1[C@H]23	10.1016/j.bmcl.2016.10.065
	11499800	88678	0	None	-2	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337503	88678	0	None	-2	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365465	88678	0	None	-2	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	25117680	198951	0	None	-13	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	434	4	1	6	4.1	CC(C)n1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CC[C@@H](N)C3)ccc21	10.1021/jm901674f
	CHEMBL599466	198951	0	None	-13	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	434	4	1	6	4.1	CC(C)n1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CC[C@@H](N)C3)ccc21	10.1021/jm901674f
	155536619	171635	0	None	-75	4	Human	5.7	pKi	=	5.7	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	254	3	4	7	-2.3	NC(=O)c1ncn([C@H]2[C@H](O)[C@H](O)[C@]3(CO)C[C@H]23)n1	10.1021/acs.jmedchem.8b01662
	CHEMBL4473739	171635	0	None	-75	4	Human	5.7	pKi	=	5.7	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	254	3	4	7	-2.3	NC(=O)c1ncn([C@H]2[C@H](O)[C@H](O)[C@]3(CO)C[C@H]23)n1	10.1021/acs.jmedchem.8b01662
	122178710	120862	0	None	-8	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	431	6	0	5	5.0	COc1cc2c(cc1OCc1ccccc1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
	CHEMBL3581255	120862	0	None	-8	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	431	6	0	5	5.0	COc1cc2c(cc1OCc1ccccc1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
	11290492	137474	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	218	1	1	3	0.8	COc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	CHEMBL376456	137474	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	218	1	1	3	0.8	COc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	5318	15400	44	None	-1	13	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL1200348	15400	44	None	-1	13	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL1221	15400	44	None	-1	13	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	1531	2235	64	None	-16	14	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
	3869	2235	64	None	-16	14	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
	7207	2235	64	None	-16	14	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
	CHEMBL429	2235	64	None	-16	14	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
	DB00598	2235	64	None	-16	14	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
	124	2933	44	None	-181	32	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
	2032	2933	44	None	-181	32	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
	4636	2933	44	None	-181	32	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
	CHEMBL762	2933	44	None	-181	32	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
	DB00935	2933	44	None	-181	32	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
	11416698	90676	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	232	1	1	3	0.7	COc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397902	90676	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	232	1	1	3	0.7	COc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	73349359	92111	0	None	-2	8	Human	5.7	pKi	=	5.7	Binding	Inhibition of 5-HT2B receptor (unknown origin) by PDSP assayInhibition of 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	341	6	1	4	2.9	COc1cc(CN[C@H]2C3C4CC5C6C4CC3C6C52)cc(OC)c1OC	10.1016/j.bmc.2013.07.045
	CHEMBL2432051	92111	0	None	-2	8	Human	5.7	pKi	=	5.7	Binding	Inhibition of 5-HT2B receptor (unknown origin) by PDSP assayInhibition of 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	341	6	1	4	2.9	COc1cc(CN[C@H]2C3C4CC5C6C4CC3C6C52)cc(OC)c1OC	10.1016/j.bmc.2013.07.045
	44582708	186256	0	None	-1	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	415	10	0	5	4.2	COc1ccc(CCN2CCC(C(=O)c3cccc(OCCF)c3OC)CC2)cc1	10.1016/j.bmc.2009.03.021
	CHEMBL489408	186256	0	None	-1	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	415	10	0	5	4.2	COc1ccc(CCN2CCC(C(=O)c3cccc(OCCF)c3OC)CC2)cc1	10.1016/j.bmc.2009.03.021
	3191	102385	93	None	-7	25	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
	CHEMBL305660	102385	93	None	-7	25	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
	44414251	77719	0	None	-158	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	470	7	0	4	4.8	COc1ccc(N2CC=C(c3ccc(Br)cc3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	CHEMBL210053	77719	0	None	-158	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	470	7	0	4	4.8	COc1ccc(N2CC=C(c3ccc(Br)cc3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	44414070	79510	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	474	7	0	4	5.7	COc1ccc(C2=C(C)CN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	CHEMBL212482	79510	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	474	7	0	4	5.7	COc1ccc(C2=C(C)CN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	49850672	56092	0	None	-794	9	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	404	5	1	5	4.1	COC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
	CHEMBL1631532	56092	0	None	-794	9	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	404	5	1	5	4.1	COC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
	44298021	193091	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	422	4	1	4	5.9	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cccnc3C(C)C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL53793	193091	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	422	4	1	4	5.9	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cccnc3C(C)C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	18931377	204749	0	None	-3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	578	11	3	8	3.2	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1cccc(Cl)c1	10.1016/S0960-894X(96)00503-3
	CHEMBL88193	204749	0	None	-3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	578	11	3	8	3.2	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1cccc(Cl)c1	10.1016/S0960-894X(96)00503-3
	18931150	205101	0	None	-31	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	393	7	2	5	2.4	COc1cc(Cl)ccc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
	CHEMBL90470	205101	0	None	-31	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	393	7	2	5	2.4	COc1cc(Cl)ccc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
	153287566	170614	0	None	-74	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	278	1	0	2	4.0	CN1CC[C@H]2c3ccccc3N(c3ccccc3)C[C@]21C	10.1021/acsmedchemlett.9b00225
	CHEMBL4459009	170614	0	None	-74	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	278	1	0	2	4.0	CN1CC[C@H]2c3ccccc3N(c3ccccc3)C[C@]21C	10.1021/acsmedchemlett.9b00225
	11292350	87513	0	None	-79	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	394	6	0	4	4.3	COc1ccc(N2Cc3cccc(C)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	CHEMBL234006	87513	0	None	-79	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	394	6	0	4	4.3	COc1ccc(N2Cc3cccc(C)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	11775262	87627	0	None	-125	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.3	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	CHEMBL234532	87627	0	None	-125	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.3	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	11430311	149515	0	None	-158	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	428	6	0	4	5.2	COc1ccc(N2C(=O)c3c(Cl)cccc3C2C)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	CHEMBL395059	149515	0	None	-158	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	428	6	0	4	5.2	COc1ccc(N2C(=O)c3c(Cl)cccc3C2C)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	11453704	149534	0	None	-79	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.4	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCCCCC1	10.1016/j.bmcl.2006.10.029
	CHEMBL395072	149534	0	None	-79	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.4	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCCCCC1	10.1016/j.bmcl.2006.10.029
	11282335	149790	0	None	-39	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.3	COc1ccc(N2Cc3cc(Cl)c(Cl)cc3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	CHEMBL395297	149790	0	None	-39	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.3	COc1ccc(N2Cc3cc(Cl)c(Cl)cc3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	11753782	12697	0	None	-31	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	419	6	0	5	4.2	COc1ccc(N2Cc3c(c4ccccc4n3C)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.10.034
	CHEMBL1188213	12697	0	None	-31	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	419	6	0	5	4.2	COc1ccc(N2Cc3c(c4ccccc4n3C)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.10.034
	CHEMBL535626	12697	0	None	-31	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	419	6	0	5	4.2	COc1ccc(N2Cc3c(c4ccccc4n3C)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.10.034
	10458785	86335	0	None	-50	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	467	6	0	5	5.1	COc1ccc(N2Cc3c(c4ccc(Cl)cc4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
	CHEMBL232045	86335	0	None	-50	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	467	6	0	5	5.1	COc1ccc(N2Cc3c(c4ccc(Cl)cc4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
	10346749	87979	0	None	-31	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	487	6	0	5	5.5	COc1ccc(N2Cc3c(c4cc(Cl)c(Cl)cc4n3C)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.10.034
	CHEMBL234947	87979	0	None	-31	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	487	6	0	5	5.5	COc1ccc(N2Cc3c(c4cc(Cl)c(Cl)cc4n3C)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.10.034
	10390089	141829	0	None	-125	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	436	6	0	5	5.2	COc1ccc(N2Cc3sc4ccccc4c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
	CHEMBL388882	141829	0	None	-125	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	436	6	0	5	5.2	COc1ccc(N2Cc3sc4ccccc4c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
	44298138	193829	0	None	-39	3	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	428	4	1	4	5.0	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(COc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL55344	193829	0	None	-39	3	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	428	4	1	4	5.0	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(COc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	162660908	180838	0	None	1	2	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	294	4	1	3	4.0	Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
	CHEMBL4763861	180838	0	None	1	2	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	294	4	1	3	4.0	Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
	162669225	182182	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	314	4	1	3	4.3	O=c1cc(CCCc2cccc(Cl)c2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
	CHEMBL4790230	182182	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	314	4	1	3	4.3	O=c1cc(CCCc2cccc(Cl)c2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
	10812577	98588	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	431	3	1	3	5.5	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(-c3cccnc3)ccc1F)CC2	10.1021/jm990388c
	CHEMBL280322	98588	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	431	3	1	3	5.5	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(-c3cccnc3)ccc1F)CC2	10.1021/jm990388c
	10249573	205859	0	None	-199	11	Human	5.7	pKi	=	5.7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandBinding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	CHEMBL94984	205859	0	None	-199	11	Human	5.7	pKi	=	5.7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandBinding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	10237852	72059	0	None	-316	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	411	7	0	6	3.6	COc1ccc(-n2ccn(-c3cccc(F)c3)c2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
	CHEMBL198712	72059	0	None	-316	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	411	7	0	6	3.6	COc1ccc(-n2ccn(-c3cccc(F)c3)c2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
	24887517	168473	0	None	-158	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	476	7	0	4	5.6	COc1ccc(N2CCC(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.05.034
	CHEMBL439504	168473	0	None	-158	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	476	7	0	4	5.6	COc1ccc(N2CCC(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.05.034
	11191906	11662	0	None	-39	12	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HT	ChEMBL	537	12	1	3	7.3	O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1	10.1016/j.bmcl.2005.06.024
	CHEMBL1181665	11662	0	None	-39	12	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HT	ChEMBL	537	12	1	3	7.3	O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1	10.1016/j.bmcl.2005.06.024
	CHEMBL187928	11662	0	None	-39	12	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HT	ChEMBL	537	12	1	3	7.3	O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1	10.1016/j.bmcl.2005.06.024
	44298079	194649	0	None	-19	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	346	3	1	4	4.2	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3ccccc32)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL56232	194649	0	None	-19	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	346	3	1	4	4.2	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3ccccc32)cn1	10.1016/s0960-894x(00)00364-4
	44298193	197697	0	None	-316	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	380	3	1	4	4.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Cl)ccc32)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL59097	197697	0	None	-316	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	380	3	1	4	4.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Cl)ccc32)cn1	10.1016/s0960-894x(00)00364-4
	10433930	50816	0	None	-999	5	Human	5.7	pKi	=	5.7	Binding	Compound was evaluated for binding affinity against human cloned 5-HT2B receptor in HEK 293 cells using [3H]5-HT as the radioligandCompound was evaluated for binding affinity against human cloned 5-HT2B receptor in HEK 293 cells using [3H]5-HT as the radioligand	ChEMBL	449	5	2	5	3.9	COc1ccc(S(=O)(=O)Nc2cc(Cl)cc(Cl)c2Cl)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
	CHEMBL157910	50816	0	None	-999	5	Human	5.7	pKi	=	5.7	Binding	Compound was evaluated for binding affinity against human cloned 5-HT2B receptor in HEK 293 cells using [3H]5-HT as the radioligandCompound was evaluated for binding affinity against human cloned 5-HT2B receptor in HEK 293 cells using [3H]5-HT as the radioligand	ChEMBL	449	5	2	5	3.9	COc1ccc(S(=O)(=O)Nc2cc(Cl)cc(Cl)c2Cl)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
	118278424	121498	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	256	3	1	4	2.9	O=c1cc(CCc2ccco2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
	CHEMBL3593951	121498	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	256	3	1	4	2.9	O=c1cc(CCc2ccco2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
	24865725	187501	0	None	-3981	12	Human	5.7	pKi	=	5.7	Binding	Displacement of radioligand from human cloned 5HT2B receptorDisplacement of radioligand from human cloned 5HT2B receptor	ChEMBL	453	8	1	5	4.2	Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm8001444
	CHEMBL497963	187501	0	None	-3981	12	Human	5.7	pKi	=	5.7	Binding	Displacement of radioligand from human cloned 5HT2B receptorDisplacement of radioligand from human cloned 5HT2B receptor	ChEMBL	453	8	1	5	4.2	Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm8001444
	9892409	100483	0	None	-398	9	Human	5.7	pKi	=	5.7	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	505	5	1	6	5.3	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCCCC2C1	10.1016/s0960-894x(02)00172-5
	CHEMBL29410	100483	0	None	-398	9	Human	5.7	pKi	=	5.7	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	505	5	1	6	5.3	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCCCC2C1	10.1016/s0960-894x(02)00172-5
	448537	159703	86	None	-21	25	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
	CHEMBL411	159703	86	None	-21	25	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
	11957541	1430	38	None	-1	15	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
	1229	1430	38	None	-1	15	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
	147	1430	38	None	-1	15	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
	170617	1430	38	None	-1	15	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
	CHEMBL6616	1430	38	None	-1	15	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
	11957541	1430	38	None	-1	15	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I](+/-)-DOI from human 5HT2B receptorDisplacement of [125I](+/-)-DOI from human 5HT2B receptor	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm2006782
	1229	1430	38	None	-1	15	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I](+/-)-DOI from human 5HT2B receptorDisplacement of [125I](+/-)-DOI from human 5HT2B receptor	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm2006782
	147	1430	38	None	-1	15	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I](+/-)-DOI from human 5HT2B receptorDisplacement of [125I](+/-)-DOI from human 5HT2B receptor	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm2006782
	170617	1430	38	None	-1	15	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I](+/-)-DOI from human 5HT2B receptorDisplacement of [125I](+/-)-DOI from human 5HT2B receptor	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm2006782
	CHEMBL6616	1430	38	None	-1	15	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I](+/-)-DOI from human 5HT2B receptorDisplacement of [125I](+/-)-DOI from human 5HT2B receptor	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm2006782
	24826867	90664	0	None	3	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	1	1	2	1.2	CCc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397890	90664	0	None	3	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	1	1	2	1.2	CCc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	11323169	179387	0	None	-1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	269	2	1	3	3.1	Cc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4746737	179387	0	None	-1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	269	2	1	3	3.1	Cc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	2220	3085	78	None	-1	13	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
	27400	3085	78	None	-1	13	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
	93	3085	78	None	-1	13	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
	CHEMBL294951	3085	78	None	-1	13	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
	DB06153	3085	78	None	-1	13	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
	118717217	120065	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	325	4	2	3	1.6	COCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3343667	120065	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	325	4	2	3	1.6	COCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3545762	120065	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	325	4	2	3	1.6	COCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	72734862	105825	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	253	1	2	2	2.0	NC(N)=NC(=O)c1ccc2c(c1)oc1ccccc12	10.1016/j.bmc.2013.10.010
	CHEMBL3092754	105825	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	253	1	2	2	2.0	NC(N)=NC(=O)c1ccc2c(c1)oc1ccccc12	10.1016/j.bmc.2013.10.010
	CHEMBL3139079	105825	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	253	1	2	2	2.0	NC(N)=NC(=O)c1ccc2c(c1)oc1ccccc12	10.1016/j.bmc.2013.10.010
	44269058	31151	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	425	6	2	4	2.6	CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1021/ml3003814
	CHEMBL14022	31151	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	425	6	2	4	2.6	CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1021/ml3003814
	157	2038	5	None	-20	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to control	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/acs.jmedchem.1c00726
	9840090	2038	5	None	-20	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to control	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/acs.jmedchem.1c00726
	CHEMBL134519	2038	5	None	-20	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to control	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/acs.jmedchem.1c00726
	1043	1552	13	None	-22	28	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	149	1552	13	None	-22	28	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	8223	1552	13	None	-22	28	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	CHEMBL442	1552	13	None	-22	28	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	DB00696	1552	13	None	-22	28	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	10251906	67441	14	None	-186	7	Human	8.6	pKi	=	8.6	Binding	Binding affinity to 5-HT2B (unknown origin) assessed as inhibition constant by liquid scintillation counter analysisBinding affinity to 5-HT2B (unknown origin) assessed as inhibition constant by liquid scintillation counter analysis	ChEMBL	427	8	1	4	3.6	COc1cc(CCNCc2ccccc2OC)c(OC)cc1I	10.1021/acs.jmedchem.2c00633
	CHEMBL1908863	67441	14	None	-186	7	Human	8.6	pKi	=	8.6	Binding	Binding affinity to 5-HT2B (unknown origin) assessed as inhibition constant by liquid scintillation counter analysisBinding affinity to 5-HT2B (unknown origin) assessed as inhibition constant by liquid scintillation counter analysis	ChEMBL	427	8	1	4	3.6	COc1cc(CCNCc2ccccc2OC)c(OC)cc1I	10.1021/acs.jmedchem.2c00633
	CHEMBL482496	67441	14	None	-186	7	Human	8.6	pKi	=	8.6	Binding	Binding affinity to 5-HT2B (unknown origin) assessed as inhibition constant by liquid scintillation counter analysisBinding affinity to 5-HT2B (unknown origin) assessed as inhibition constant by liquid scintillation counter analysis	ChEMBL	427	8	1	4	3.6	COc1cc(CCNCc2ccccc2OC)c(OC)cc1I	10.1021/acs.jmedchem.2c00633
	72734867	105885	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	268	1	3	3	2.0	NC(N)=NC(=O)c1ccc2c(c1)Oc1ccccc1N2	10.1016/j.bmc.2013.10.010
	CHEMBL3092757	105885	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	268	1	3	3	2.0	NC(N)=NC(=O)c1ccc2c(c1)Oc1ccccc1N2	10.1016/j.bmc.2013.10.010
	CHEMBL3139241	105885	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	268	1	3	3	2.0	NC(N)=NC(=O)c1ccc2c(c1)Oc1ccccc1N2	10.1016/j.bmc.2013.10.010
	230	4056	18	None	-2	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	243	3	1	4	2.7	CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C	10.1016/j.bmc.2007.12.009
	3045225	4056	18	None	-2	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	243	3	1	4	2.7	CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C	10.1016/j.bmc.2007.12.009
	CHEMBL407909	4056	18	None	-2	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	243	3	1	4	2.7	CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C	10.1016/j.bmc.2007.12.009
	67781610	166401	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	357	3	0	2	4.7	CN(C)CC/C=C1\c2ccc(Br)cc2COc2ccccc21	10.1021/acsmedchemlett.8b00300
	CHEMBL4287193	166401	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	357	3	0	2	4.7	CN(C)CC/C=C1\c2ccc(Br)cc2COc2ccccc21	10.1021/acsmedchemlett.8b00300
	16062910	96978	0	None	-6	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	329	3	1	3	3.7	Cc1ccc(-c2nc(Cc3ccccc3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL269974	96978	0	None	-6	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	329	3	1	3	3.7	Cc1ccc(-c2nc(Cc3ccccc3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	9839920	101238	0	None	10	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	316	2	2	3	4.4	Cn1ccc2cc(NC(=O)Nc3ccnc4ccccc34)ccc21	10.1016/s0960-894x(01)00343-2
	CHEMBL299498	101238	0	None	10	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	316	2	2	3	4.4	Cn1ccc2cc(NC(=O)Nc3ccnc4ccccc34)ccc21	10.1016/s0960-894x(01)00343-2
	146709966	175206	0	None	338	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2ccc3ccccc3c2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	CHEMBL4583909	175206	0	None	338	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2ccc3ccccc3c2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	1042	1551	20	None	-7	16	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	148	1551	20	None	-7	16	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	443884	1551	20	None	-7	16	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	CHEMBL119443	1551	20	None	-7	16	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	DB01253	1551	20	None	-7	16	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	11536844	114624	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343672	114624	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	206	2457	10	None	-1	24	Human	8.6	pKi	=	8.6	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/j.ejmech.2019.04.064
	68848	2457	10	None	-1	24	Human	8.6	pKi	=	8.6	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/j.ejmech.2019.04.064
	CHEMBL12314	2457	10	None	-1	24	Human	8.6	pKi	=	8.6	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/j.ejmech.2019.04.064
	4376990	192407	4	None	-1	11	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5207529	192407	4	None	-1	11	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222754	192407	4	None	-1	11	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	153061504	172241	0	None	15	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2c(ccc3ccccc23)OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	CHEMBL4513930	172241	0	None	15	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2c(ccc3ccccc23)OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	59752538	180570	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	339	3	1	4	3.7	CC(C)n1nc2c(c1-c1ccc(OC(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4760784	180570	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	339	3	1	4	3.7	CC(C)n1nc2c(c1-c1ccc(OC(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	11414582	180756	0	None	-3	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	271	2	1	3	2.7	Fc1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4762886	180756	0	None	-3	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	271	2	1	3	2.7	Fc1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	59752638	181815	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	253	2	1	3	2.6	c1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4785470	181815	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	253	2	1	3	2.6	c1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	189	3436	31	None	-5	17	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/acs.jnatprod.2c00365
	5163	3436	31	None	-5	17	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/acs.jnatprod.2c00365
	CHEMBL297784	3436	31	None	-5	17	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/acs.jnatprod.2c00365
	3037629	183989	13	None	1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to control	ChEMBL	396	5	1	5	3.6	C=C[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	CHEMBL4848517	183989	13	None	1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to control	ChEMBL	396	5	1	5	3.6	C=C[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	66647021	120164	0	None	-9	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	257	2	0	1	4.2	CN(C)[C@@H]1Cc2ccccc2[C@@H](C2CCCCC2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402656	120164	0	None	-9	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	257	2	0	1	4.2	CN(C)[C@@H]1Cc2ccccc2[C@@H](C2CCCCC2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547009	120164	0	None	-9	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	257	2	0	1	4.2	CN(C)[C@@H]1Cc2ccccc2[C@@H](C2CCCCC2)C1	10.1016/j.bmc.2015.01.060
	118729256	120197	0	None	6	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	296	3	0	3	3.6	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc([N+](=O)[O-])c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402670	120197	0	None	6	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	296	3	0	3	3.6	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc([N+](=O)[O-])c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547156	120197	0	None	6	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	296	3	0	3	3.6	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc([N+](=O)[O-])c2)C1	10.1016/j.bmc.2015.01.060
	16062785	94678	0	None	-5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	285	2	1	3	3.1	CC(C)c1nc2c(c(-c3ccc(F)cc3)n1)CCNCC2	10.1016/j.bmcl.2008.01.090
	CHEMBL255543	94678	0	None	-5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	285	2	1	3	3.1	CC(C)c1nc2c(c(-c3ccc(F)cc3)n1)CCNCC2	10.1016/j.bmcl.2008.01.090
	16062784	94724	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	318	2	1	4	3.4	N#Cc1ccc(-c2nc(C3CCCC3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL255802	94724	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	318	2	1	4	3.4	N#Cc1ccc(-c2nc(C3CCCC3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	752521	197060	7	None	12	9	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	295	1	3	5	1.9	CC1(C)N=C(N)N=C(Nc2cccc(Br)c2)N1	10.1021/acs.jmedchem.5b01631
	CHEMBL582877	197060	7	None	12	9	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	295	1	3	5	1.9	CC1(C)N=C(N)N=C(Nc2cccc(Br)c2)N1	10.1021/acs.jmedchem.5b01631
	118729260	120176	0	None	1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(C(F)(F)F)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402672	120176	0	None	1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(C(F)(F)F)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547044	120176	0	None	1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(C(F)(F)F)c2)C1	10.1016/j.bmc.2015.01.060
	118729274	120199	0	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	327	3	0	1	5.4	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(-c3ccccc3)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402681	120199	0	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	327	3	0	1	5.4	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(-c3ccccc3)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547175	120199	0	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	327	3	0	1	5.4	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(-c3ccccc3)c2)C1	10.1016/j.bmc.2015.01.060
	44435219	91360	0	None	-6	4	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assay	ChEMBL	367	2	0	2	6.2	O=C(Cc1ccc2ccccc2c1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
	CHEMBL241115	91360	0	None	-6	4	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assay	ChEMBL	367	2	0	2	6.2	O=C(Cc1ccc2ccccc2c1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
	155556618	173905	0	None	-1905	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	417	6	3	7	2.7	O[C@H]1[C@H](n2cnc3c(NC(C4CCC4)C4CCC4)ncnc32)[C@H]2C[C@@]2(CCl)[C@H]1O	10.1021/acs.jmedchem.8b01662
	CHEMBL4554295	173905	0	None	-1905	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	417	6	3	7	2.7	O[C@H]1[C@H](n2cnc3c(NC(C4CCC4)C4CCC4)ncnc32)[C@H]2C[C@@]2(CCl)[C@H]1O	10.1021/acs.jmedchem.8b01662
	5897	104732	71	None	-1	3	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	223	1	1	1	3.2	CC(=O)Nc1ccc2c(c1)Cc1ccccc1-2	nan
	CHEMBL311469	104732	71	None	-1	3	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	223	1	1	1	3.2	CC(=O)Nc1ccc2c(c1)Cc1ccccc1-2	nan
	9926401	140344	0	None	-4	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819556	140344	0	None	-4	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819732	140344	0	None	-4	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	71459553	83282	5	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by scintillation counting analysis	ChEMBL	406	7	0	4	5.3	COc1ccc2c(C)c(C(=O)N(CCCN3CCCCC3)c3ccccc3)oc2c1	10.1016/j.bmc.2012.09.044
	CHEMBL2205360	83282	5	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by scintillation counting analysis	ChEMBL	406	7	0	4	5.3	COc1ccc2c(C)c(C(=O)N(CCCN3CCCCC3)c3ccccc3)oc2c1	10.1016/j.bmc.2012.09.044
	9926401	140344	0	None	-4	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819556	140344	0	None	-4	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819732	140344	0	None	-4	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	155554410	173822	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	331	2	2	5	0.6	Cc1cccc(C)c1N1C(=O)[C@H](CO)NC2(CCN(C)CC2)C1=O	10.1016/j.ejmech.2018.12.048
	CHEMBL4552298	173822	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	331	2	2	5	0.6	Cc1cccc(C)c1N1C(=O)[C@H](CO)NC2(CCN(C)CC2)C1=O	10.1016/j.ejmech.2018.12.048
	11615459	197568	0	None	10	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1cccc2c1C(=O)NC1CNCCN21	10.1016/j.bmcl.2009.12.014
	CHEMBL590078	197568	0	None	10	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1cccc2c1C(=O)NC1CNCCN21	10.1016/j.bmcl.2009.12.014
	122186881	122466	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	429	4	0	5	5.2	CCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	CHEMBL3608451	122466	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	429	4	0	5	5.2	CCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	11209786	136716	0	None	-6	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	296	1	1	2	2.7	O=C1c2c(cc(C3CC3)cc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL375170	136716	0	None	-6	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	296	1	1	2	2.7	O=C1c2c(cc(C3CC3)cc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	155558626	174189	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	355	6	3	6	2.9	Nc1nc(NCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
	CHEMBL4561016	174189	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	355	6	3	6	2.9	Nc1nc(NCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
	11336079	83063	0	None	-6	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	280	0	1	2	1.8	C#Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL220115	83063	0	None	-6	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	280	0	1	2	1.8	C#Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	11264955	203253	0	None	-6	3	Human	7.7	pKi	=	7.7	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	240	3	1	3	2.3	CSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	CHEMBL76474	203253	0	None	-6	3	Human	7.7	pKi	=	7.7	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	240	3	1	3	2.3	CSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	20824945	67246	0	None	-16	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	202	0	1	2	1.7	Cc1ccc2c(c1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
	CHEMBL190124	67246	0	None	-16	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	202	0	1	2	1.7	Cc1ccc2c(c1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
	196129	67456	12	None	-26	15	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
	CHEMBL1909065	67456	12	None	-26	15	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
	118055334	176896	0	None	-34	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	266	0	1	2	2.5	CC1CN2CCNCc3ccc(Br)c1c32	10.1016/j.bmcl.2019.126929
	CHEMBL4639090	176896	0	None	-34	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	266	0	1	2	2.5	CC1CN2CCNCc3ccc(Br)c1c32	10.1016/j.bmcl.2019.126929
	24826963	90684	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	0	1	2	1.3	Cc1cc(C)c2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397910	90684	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	0	1	2	1.3	Cc1cc(C)c2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	71681897	90688	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	258	0	1	3	1.0	O=C1c2ccc3c(c2C[C@@H]2CNCCN12)OCCC3	10.1016/j.bmcl.2013.04.061
	CHEMBL2397914	90688	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	258	0	1	3	1.0	O=C1c2ccc3c(c2C[C@@H]2CNCCN12)OCCC3	10.1016/j.bmcl.2013.04.061
	25123014	198747	0	None	-6	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	392	3	2	5	3.1	N[C@H]1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
	CHEMBL598229	198747	0	None	-6	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	392	3	2	5	3.1	N[C@H]1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
	126769	204323	35	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	266	2	2	3	3.2	Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc21	10.1016/j.bmcl.2016.05.079
	CHEMBL536255	204323	35	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	266	2	2	3	3.2	Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc21	10.1016/j.bmcl.2016.05.079
	CHEMBL85194	204323	35	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	266	2	2	3	3.2	Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc21	10.1016/j.bmcl.2016.05.079
	189	3436	31	None	-5	17	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1039/C4MD00418C
	5163	3436	31	None	-5	17	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1039/C4MD00418C
	CHEMBL297784	3436	31	None	-5	17	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1039/C4MD00418C
	127037059	136014	0	None	10	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	445	11	0	5	5.6	COc1ccc(CCN(CC/C=C\c2ccccc2)Cc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3736516	136014	0	None	10	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	445	11	0	5	5.6	COc1ccc(CCN(CC/C=C\c2ccccc2)Cc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL4777443	212286	0	None	11	14	Human	7.7	pKi	=	7.7	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000741a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000741a HTR2B	ChEMBL		None	None	None		CC(C)(C)OC(=O)N1CCCC1CN[C@H]1CC[C@@](c2cc(F)ccc2F)(S(=O)(=O)c2ccc(Cl)cc2)CC1	nan
	70687202	77624	0	None	-10	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	188	0	1	2	1.4	C[C@@H]1CNC[C@@H]2Cc3ccccc3N21	10.1016/j.bmcl.2005.05.074
	CHEMBL2096809	77624	0	None	-10	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	188	0	1	2	1.4	C[C@@H]1CNC[C@@H]2Cc3ccccc3N21	10.1016/j.bmcl.2005.05.074
	18715558	73534	0	None	-5	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3ccncc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL201897	73534	0	None	-5	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3ccncc3c21	10.1016/j.bmcl.2005.10.029
	44451390	155209	2	None	-4	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	210	1	2	2	2.1	CNc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
	CHEMBL405717	155209	2	None	-4	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	210	1	2	2	2.1	CNc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
	118729246	120175	0	None	-2	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(Br)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402663	120175	0	None	-2	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(Br)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547043	120175	0	None	-2	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(Br)cc2)C1	10.1016/j.bmc.2015.01.060
	16062143	97245	0	None	-19	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	283	2	1	3	3.2	Fc1ccc(-c2nc(C3CCC3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL271318	97245	0	None	-19	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	283	2	1	3	3.2	Fc1ccc(-c2nc(C3CCC3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
	134146585	148377	0	None	2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	366	3	3	8	-0.4	CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N(C)C)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3941738	148377	0	None	2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	366	3	3	8	-0.4	CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N(C)C)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	117209911	185747	1	None	-26	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4874854	185747	1	None	-26	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	24826786	90655	0	None	-8	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	202	0	1	2	0.7	O=C1c2ccccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397881	90655	0	None	-8	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	202	0	1	2	0.7	O=C1c2ccccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	10330266	21203	0	None	-3	4	Human	6.7	pKi	=	6.7	Binding	Compound was tested for the displacement of [3H]5-HT from cloned human 5-hydroxytryptamine 2B receptorCompound was tested for the displacement of [3H]5-HT from cloned human 5-hydroxytryptamine 2B receptor	ChEMBL	194	3	1	2	2.3	CN(C)CCc1c[nH]c2ccsc12	10.1021/jm980692q
	CHEMBL13147	21203	0	None	-3	4	Human	6.7	pKi	=	6.7	Binding	Compound was tested for the displacement of [3H]5-HT from cloned human 5-hydroxytryptamine 2B receptorCompound was tested for the displacement of [3H]5-HT from cloned human 5-hydroxytryptamine 2B receptor	ChEMBL	194	3	1	2	2.3	CN(C)CCc1c[nH]c2ccsc12	10.1021/jm980692q
	4011	81996	43	None	-20	23	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
	CHEMBL21731	81996	43	None	-20	23	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
	155512086	169054	0	None	-407	5	Human	6.7	pKi	=	6.7	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	399	6	4	8	1.5	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CCC4)C4CCC4)ncnc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	CHEMBL4436786	169054	0	None	-407	5	Human	6.7	pKi	=	6.7	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	399	6	4	8	1.5	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CCC4)C4CCC4)ncnc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	137645406	157360	0	None	-269	13	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	491	8	0	7	5.4	COc1ccccc1N1CCC2(CCN(CCCSc3nnc(-c4ccccc4)n3C)CC2)CC1	10.1021/acs.jmedchem.9b00412
	CHEMBL4084262	157360	0	None	-269	13	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	491	8	0	7	5.4	COc1ccccc1N1CCC2(CCN(CCCSc3nnc(-c4ccccc4)n3C)CC2)CC1	10.1021/acs.jmedchem.9b00412
	CHEMBL4526351	212231	0	None	-1	4	Human	5.7	pKi	=	5.7	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000703a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000703a HTR2B	ChEMBL		None	None	None		Cc1cc(NC(=O)c2cccc(S(F)(F)(F)(F)F)c2)cc(-n2ccn3nc(-c4cccnc4)cc23)c1	nan
	117209857	184555	1	None	-5	8	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4856702	184555	1	None	-5	8	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	4601	205020	29	None	-4	17	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
	CHEMBL1201023	205020	29	None	-4	17	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
	CHEMBL900	205020	29	None	-4	17	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
	68617	203816	60	None	-15	25	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	CHEMBL1709	203816	60	None	-15	25	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	CHEMBL809	203816	60	None	-15	25	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	104697662	144872	1	None	1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	293	3	2	4	3.3	Clc1cccc(CNc2nc(Cl)nc3[nH]cnc23)c1	10.1021/acs.jmedchem.6b01183
	CHEMBL3914002	144872	1	None	1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	293	3	2	4	3.3	Clc1cccc(CNc2nc(Cl)nc3[nH]cnc23)c1	10.1021/acs.jmedchem.6b01183
	71682217	90687	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	246	1	1	3	1.0	COc1c(C)ccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397913	90687	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	246	1	1	3	1.0	COc1c(C)ccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	44409032	74672	0	None	-4	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	223	0	1	3	1.5	C[C@@H]1CNC[C@@H]2Cc3ccc(Cl)nc3N21	10.1016/j.bmcl.2005.11.083
	CHEMBL203396	74672	0	None	-4	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	223	0	1	3	1.5	C[C@@H]1CNC[C@@H]2Cc3ccc(Cl)nc3N21	10.1016/j.bmcl.2005.11.083
	165193	3138	60	None	-72	42	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	2303	3138	60	None	-72	42	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	4946	3138	60	None	-72	42	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	564	3138	60	None	-72	42	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	62882	3138	60	None	-72	42	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	63	3138	60	None	-72	42	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	66366	3138	60	None	-72	42	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	91536	3138	60	None	-72	42	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	CHEMBL27	3138	60	None	-72	42	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	CHEMBL452861	3138	60	None	-72	42	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	DB00571	3138	60	None	-72	42	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	2353	100643	75	None	-7	5	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	336	2	0	4	3.1	COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2	nan
	CHEMBL12089	100643	75	None	-7	5	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	336	2	0	4	3.1	COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2	nan
	CHEMBL295124	100643	75	None	-7	5	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	336	2	0	4	3.1	COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2	nan
	10440	2642	15	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	139030523	2642	15	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	CHEMBL4449712	2642	15	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	3117	206106	100	None	-8	16	Human	4.7	pKi	=	4.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
	CHEMBL964	206106	100	None	-8	16	Human	4.7	pKi	=	4.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
	145992489	166424	0	None	-6	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	535	7	1	2	7.8	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC=C(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	CHEMBL4287623	166424	0	None	-6	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	535	7	1	2	7.8	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC=C(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	118055195	177443	0	None	-9	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	202	0	1	2	2.0	Cc1ccc2c3c1C(C)CN3CCNC2	10.1016/j.bmcl.2019.126929
	CHEMBL4646618	177443	0	None	-9	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	202	0	1	2	2.0	Cc1ccc2c3c1C(C)CN3CCNC2	10.1016/j.bmcl.2019.126929
	122178704	120856	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	397	6	0	5	4.6	CCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL3581249	120856	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	397	6	0	5	4.6	CCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	16047544	12539	7	None	5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	225	2	1	1	2.5	NCC1CC1c1ccccc1Br	10.1021/jm801354e
	CHEMBL1187185	12539	7	None	5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	225	2	1	1	2.5	NCC1CC1c1ccccc1Br	10.1021/jm801354e
	CHEMBL492916	12539	7	None	5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	225	2	1	1	2.5	NCC1CC1c1ccccc1Br	10.1021/jm801354e
	16062911	97262	0	None	-27	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	383	3	1	3	4.4	FC(F)(F)c1ccc(-c2nc(Cc3ccccc3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL271418	97262	0	None	-27	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	383	3	1	3	4.4	FC(F)(F)c1ccc(-c2nc(Cc3ccccc3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	189	3436	31	None	-5	17	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting methodDisplacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting method	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1039/C8MD00204E
	5163	3436	31	None	-5	17	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting methodDisplacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting method	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1039/C8MD00204E
	CHEMBL297784	3436	31	None	-5	17	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting methodDisplacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting method	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1039/C8MD00204E
	11658860	2312	47	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2019.126929
	2941	2312	47	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2019.126929
	4374	2312	47	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2019.126929
	CHEMBL360328	2312	47	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2019.126929
	DB04871	2312	47	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2019.126929
	11187156	135831	0	None	-3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	312	3	1	2	3.1	CCCCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL373483	135831	0	None	-3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	312	3	1	2	3.1	CCCCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	16062270	97224	0	None	-100	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	297	2	1	3	3.6	Fc1ccc(-c2nc(C3CCCC3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL271212	97224	0	None	-100	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	297	2	1	3	3.6	Fc1ccc(-c2nc(C3CCCC3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
	16062266	97244	0	None	-169	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	337	3	1	3	3.7	Fc1ccc(Cc2nc3c(c(-c4ccc(F)cc4)n2)CNCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL271317	97244	0	None	-169	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	337	3	1	3	3.7	Fc1ccc(Cc2nc3c(c(-c4ccc(F)cc4)n2)CNCC3)cc1	10.1016/j.bmcl.2008.01.090
	2284	3133	27	None	-16	28	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	4926	3133	27	None	-16	28	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	7281	3133	27	None	-16	28	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	CHEMBL564	3133	27	None	-16	28	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	DB00420	3133	27	None	-16	28	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	9837204	74344	1	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	209	0	1	3	1.1	Clc1ccc2c(n1)N1CCNCC1C2	10.1016/j.bmcl.2005.11.083
	CHEMBL203025	74344	1	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	209	0	1	3	1.1	Clc1ccc2c(n1)N1CCNCC1C2	10.1016/j.bmcl.2005.11.083
	49865829	15983	0	None	22	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	330	1	1	3	4.1	O=C(Nc1ccccc1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	CHEMBL1224031	15983	0	None	22	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	330	1	1	3	4.1	O=C(Nc1ccccc1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	16062139	157125	0	None	-204	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	285	3	1	3	3.4	CCC(C)c1nc2c(c(-c3ccc(F)cc3)n1)CNCC2	10.1016/j.bmcl.2008.01.090
	CHEMBL408154	157125	0	None	-204	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	285	3	1	3	3.4	CCC(C)c1nc2c(c(-c3ccc(F)cc3)n1)CNCC2	10.1016/j.bmcl.2008.01.090
	71463061	83381	0	None	-3	9	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	339	5	1	4	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1OC	10.1016/j.bmcl.2012.08.046
	CHEMBL2205813	83381	0	None	-3	9	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	339	5	1	4	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1OC	10.1016/j.bmcl.2012.08.046
	2351	3234	60	None	-7	21	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	2820	3234	60	None	-7	21	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	5035	3234	60	None	-7	21	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	CHEMBL81	3234	60	None	-7	21	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	DB00481	3234	60	None	-7	21	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	156012918	176874	0	None	-7	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	222	0	1	2	2.2	Clc1ccc2c3c1CCCN3CCNC2	10.1016/j.bmcl.2019.126929
	CHEMBL4638807	176874	0	None	-7	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	222	0	1	2	2.2	Clc1ccc2c3c1CCCN3CCNC2	10.1016/j.bmcl.2019.126929
	24826870	90672	0	None	-4	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	1	1	2	1.2	CCc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397898	90672	0	None	-4	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	1	1	2	1.2	CCc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	444795	139469	102	None	3	2	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1	nan
	CHEMBL38	139469	102	None	3	2	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1	nan
	136118613	92631	0	None	5	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3cccc(Br)c23)C1=O	10.1016/j.bmc.2013.09.011
	CHEMBL2442275	92631	0	None	5	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3cccc(Br)c23)C1=O	10.1016/j.bmc.2013.09.011
	26987	936	29	None	-47	21	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	6063	936	29	None	-47	21	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	671	936	29	None	-47	21	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	CHEMBL1626	936	29	None	-47	21	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	DB00283	936	29	None	-47	21	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	46230099	197632	0	None	-2	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	251	0	2	3	1.2	O=C1NC2CCNCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
	CHEMBL590483	197632	0	None	-2	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	251	0	2	3	1.2	O=C1NC2CCNCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
	11514226	88681	0	None	-5	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337494	88681	0	None	-5	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365470	88681	0	None	-5	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	15560577	184759	6	None	1	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to control	ChEMBL	398	5	1	5	3.8	CC[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	CHEMBL4859858	184759	6	None	1	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to control	ChEMBL	398	5	1	5	3.8	CC[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	134152052	152549	0	None	3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	432	6	4	8	1.1	CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3976121	152549	0	None	3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	432	6	4	8	1.1	CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	134152052	152549	0	None	3	5	Human	7.6	pKi	=	7.6	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	432	6	4	8	1.1	CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	CHEMBL3976121	152549	0	None	3	5	Human	7.6	pKi	=	7.6	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	432	6	4	8	1.1	CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	CHEMBL5094493	213723	0	None	-11	7	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCCN(CCC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	72698087	103511	0	None	-2089	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human 5HT2BBinding affinity to human 5HT2B	ChEMBL	407	5	0	4	5.0	Fc1cccc2c1nc(OCC1CCN(CCC(F)(F)F)CC1)c1cccnc12	10.1016/j.bmc.2013.08.061
	CHEMBL3093186	103511	0	None	-2089	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human 5HT2BBinding affinity to human 5HT2B	ChEMBL	407	5	0	4	5.0	Fc1cccc2c1nc(OCC1CCN(CCC(F)(F)F)CC1)c1cccnc12	10.1016/j.bmc.2013.08.061
	10251906	67441	14	None	-186	7	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	427	8	1	4	3.6	COc1cc(CCNCc2ccccc2OC)c(OC)cc1I	10.1016/j.bmc.2008.04.050
	CHEMBL1908863	67441	14	None	-186	7	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	427	8	1	4	3.6	COc1cc(CCNCc2ccccc2OC)c(OC)cc1I	10.1016/j.bmc.2008.04.050
	CHEMBL482496	67441	14	None	-186	7	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	427	8	1	4	3.6	COc1cc(CCNCc2ccccc2OC)c(OC)cc1I	10.1016/j.bmc.2008.04.050
	155539605	172276	0	None	3	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	313	1	0	4	2.1	CC1=NC2(CCN(C)CC2)C(=O)N(c2c(C)cccc2C)C1=O	10.1016/j.ejmech.2018.12.048
	CHEMBL4514672	172276	0	None	3	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	313	1	0	4	2.1	CC1=NC2(CCN(C)CC2)C(=O)N(c2c(C)cccc2C)C1=O	10.1016/j.ejmech.2018.12.048
	127034730	135916	0	None	9	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	523	14	0	8	5.1	COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)Cc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3735643	135916	0	None	9	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	523	14	0	8	5.1	COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)Cc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	46914927	15245	0	None	14	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	382	8	0	4	4.5	FCCCOc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
	CHEMBL1214893	15245	0	None	14	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	382	8	0	4	4.5	FCCCOc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
	91864602	140207	0	None	-66	8	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	313	5	0	2	4.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818047	140207	0	None	-66	8	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	313	5	0	2	4.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.05.053
	135514796	92626	0	None	-2	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	226	1	4	2	1.2	N=C1NC(=O)/C(=C\c2c[nH]c3ccccc23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2442270	92626	0	None	-2	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	226	1	4	2	1.2	N=C1NC(=O)/C(=C\c2c[nH]c3ccccc23)N1	10.1016/j.bmc.2013.09.011
	142601323	185259	0	None	-9	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4867560	185259	0	None	-9	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
	3973	206439	104	None	-44	3	Human	4.6	pKi	=	4.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	2	0	4	3.3	O=c1cc(N2CCOCC2)oc2c(-c3ccccc3)cccc12	nan
	CHEMBL98350	206439	104	None	-44	3	Human	4.6	pKi	=	4.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	2	0	4	3.3	O=c1cc(N2CCOCC2)oc2c(-c3ccccc3)cccc12	nan
	3157	1442	69	None	-37	12	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
	7170	1442	69	None	-37	12	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
	954	1442	69	None	-37	12	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
	CHEMBL707	1442	69	None	-37	12	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
	DB00590	1442	69	None	-37	12	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
	91864602	140207	0	None	-66	8	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	313	5	0	2	4.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818047	140207	0	None	-66	8	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	313	5	0	2	4.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.05.053
	16115388	136841	0	None	-2	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	284	1	1	2	2.6	CC[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	CHEMBL375302	136841	0	None	-2	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	284	1	1	2	2.6	CC[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	11185858	84368	0	None	-7	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@@H]1CN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2CN1	10.1021/jm0612968
	CHEMBL223271	84368	0	None	-7	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@@H]1CN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2CN1	10.1021/jm0612968
	71061785	159949	0	None	-6	4	Mouse	5.6	pKi	=	5.6	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	386	5	0	4	3.0	O=C(CN1CCO[C@@H](COc2cccc(Cl)c2)C1)N1CCc2ccccc21	nan
	CHEMBL4112056	159949	0	None	-6	4	Mouse	5.6	pKi	=	5.6	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	386	5	0	4	3.0	O=C(CN1CCO[C@@H](COc2cccc(Cl)c2)C1)N1CCc2ccccc21	nan
	10430623	18488	22	None	-213	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	392	3	2	5	3.0	O=S(=O)(c1cccc2ccccc12)c1n[nH]c2ccc(N3CCNCC3)cc12	10.1021/jm1007825
	CHEMBL1277105	18488	22	None	-213	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	392	3	2	5	3.0	O=S(=O)(c1cccc2ccccc12)c1n[nH]c2ccc(N3CCNCC3)cc12	10.1021/jm1007825
	72901200	119272	21	None	-162	4	Human	6.6	pKi	=	6.6	Binding	Selectivity interaction (PRESTO-Tango GPCR-ome screening) EUB0000539a HTR2BSelectivity interaction (PRESTO-Tango GPCR-ome screening) EUB0000539a HTR2B	ChEMBL	322	7	2	4	3.8	Cc1ccc2nc(CNCCCOc3ccccc3)cc(O)c2c1	nan
	CHEMBL3480577	119272	21	None	-162	4	Human	6.6	pKi	=	6.6	Binding	Selectivity interaction (PRESTO-Tango GPCR-ome screening) EUB0000539a HTR2BSelectivity interaction (PRESTO-Tango GPCR-ome screening) EUB0000539a HTR2B	ChEMBL	322	7	2	4	3.8	Cc1ccc2nc(CNCCCOc3ccccc3)cc(O)c2c1	nan
	11587397	88627	0	None	-12	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337489	88627	0	None	-12	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2364893	88627	0	None	-12	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	6726	1254	46	None	-7	13	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	7151	1254	46	None	-7	13	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	749	1254	46	None	-7	13	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	CHEMBL648	1254	46	None	-7	13	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	DB01176	1254	46	None	-7	13	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	44579715	192649	0	None	-2238	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	405	4	3	7	2.7	O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NCc3cccc(Cl)c3)nc(Cl)nc21	10.1021/acs.jmedchem.6b01183
	CHEMBL523797	192649	0	None	-2238	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	405	4	3	7	2.7	O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NCc3cccc(Cl)c3)nc(Cl)nc21	10.1021/acs.jmedchem.6b01183
	46230048	197610	0	None	2	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1cccc2c1N1CCNCC1NC2=O	10.1016/j.bmcl.2009.12.014
	CHEMBL590332	197610	0	None	2	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1cccc2c1N1CCNCC1NC2=O	10.1016/j.bmcl.2009.12.014
	118055215	176882	0	None	-5	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	216	0	1	2	2.2	Cc1ccc2c3c1C(C)(C)CN3CCNC2	10.1016/j.bmcl.2019.126929
	CHEMBL4638879	176882	0	None	-5	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	216	0	1	2	2.2	Cc1ccc2c3c1C(C)(C)CN3CCNC2	10.1016/j.bmcl.2019.126929
	1355	1980	82	None	-1	15	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	142	1980	82	None	-1	15	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	CHEMBL478	1980	82	None	-1	15	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	DB12110	1980	82	None	-1	15	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	11652452	88697	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	270	0	1	2	1.8	CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337492	88697	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	270	0	1	2	1.8	CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365703	88697	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	270	0	1	2	1.8	CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21	10.1016/j.bmcl.2012.10.091
	162668650	182091	0	None	-7	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	284	3	2	4	2.9	CNc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4789085	182091	0	None	-7	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	284	3	2	4	2.9	CNc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	3251	4009	50	None	-79	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1016/j.ejmech.2011.06.023
	5684	4009	50	None	-79	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1016/j.ejmech.2011.06.023
	80	4009	50	None	-79	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1016/j.ejmech.2011.06.023
	CHEMBL31354	4009	50	None	-79	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1016/j.ejmech.2011.06.023
	1355	1980	82	None	-1	15	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	142	1980	82	None	-1	15	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	CHEMBL478	1980	82	None	-1	15	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	DB12110	1980	82	None	-1	15	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	16115381	83030	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	CHEMBL219837	83030	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	10015055	2072	4	None	-120	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	251	2	0	1	3.7	CN([C@H]1Cc2ccccc2[C@@H](C1)c1ccccc1)C	10.1016/j.bmc.2015.01.060
	1212	2072	4	None	-120	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	251	2	0	1	3.7	CN([C@H]1Cc2ccccc2[C@@H](C1)c1ccccc1)C	10.1016/j.bmc.2015.01.060
	CHEMBL3402679	2072	4	None	-120	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	251	2	0	1	3.7	CN([C@H]1Cc2ccccc2[C@@H](C1)c1ccccc1)C	10.1016/j.bmc.2015.01.060
	46884100	7935	0	None	-104	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	314	5	2	3	3.0	O=C(NCc1ccc(Oc2cccc(F)c2)cc1)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	CHEMBL1090757	7935	0	None	-104	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	314	5	2	3	3.0	O=C(NCc1ccc(Oc2cccc(F)c2)cc1)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	145978665	162966	0	None	1	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	246	2	2	3	2.4	C[C@@H]1SC(c2c[nH]c3ccccc23)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	CHEMBL4202582	162966	0	None	1	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	246	2	2	3	2.4	C[C@@H]1SC(c2c[nH]c3ccccc23)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	2142	3047	54	None	-43	36	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
	4920903	3047	54	None	-43	36	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
	502	3047	54	None	-43	36	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
	5775	3047	54	None	-43	36	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
	CHEMBL597	3047	54	None	-43	36	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
	DB00692	3047	54	None	-43	36	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
	56678761	65337	0	None	2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	364	7	0	4	4.2	COc1cccc(CCCN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1016/j.bmcl.2011.08.029
	CHEMBL1834257	65337	0	None	2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	364	7	0	4	4.2	COc1cccc(CCCN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1016/j.bmcl.2011.08.029
	46914773	15255	0	None	1	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	368	7	0	4	4.1	FCCOc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
	CHEMBL1214958	15255	0	None	1	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	368	7	0	4	4.1	FCCOc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
	9921064	126657	18	None	-8	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5-HT2B receptor (unknown origin)Binding affinity to 5-HT2B receptor (unknown origin)	ChEMBL	236	3	1	1	3.2	Cc1[nH]c2ccc(Cl)cc2c1CCN(C)C	10.1021/acs.jmedchem.5b00179
	CHEMBL365751	126657	18	None	-8	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5-HT2B receptor (unknown origin)Binding affinity to 5-HT2B receptor (unknown origin)	ChEMBL	236	3	1	1	3.2	Cc1[nH]c2ccc(Cl)cc2c1CCN(C)C	10.1021/acs.jmedchem.5b00179
	22254068	65639	24	None	-173	4	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	423	5	2	6	4.0	CS(=O)(=O)NC[C@H]1CC[C@H](Nc2nc3c(s2)CCSc2ccccc2-3)CC1	10.1016/j.bmcl.2011.06.124
	CHEMBL1836317	65639	24	None	-173	4	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	423	5	2	6	4.0	CS(=O)(=O)NC[C@H]1CC[C@H](Nc2nc3c(s2)CCSc2ccccc2-3)CC1	10.1016/j.bmcl.2011.06.124
	11536299	182704	6	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	266	3	1	3	3.3	O=c1cc(CCc2ccccc2)oc2cccc(O)c12	10.1016/j.bmcl.2014.02.029
	CHEMBL479683	182704	6	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	266	3	1	3	3.3	O=c1cc(CCc2ccccc2)oc2cccc(O)c12	10.1016/j.bmcl.2014.02.029
	145990586	166290	0	None	-19	11	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5-HT2B receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assayBinding affinity to 5-HT2B receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assay	ChEMBL	297	2	2	4	2.6	COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2	10.1039/C7MD00656J
	CHEMBL4285281	166290	0	None	-19	11	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5-HT2B receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assayBinding affinity to 5-HT2B receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assay	ChEMBL	297	2	2	4	2.6	COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2	10.1039/C7MD00656J
	136118660	75903	0	None	-1	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3cc(Br)ccc23)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2058428	75903	0	None	-1	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3cc(Br)ccc23)N1C	10.1016/j.bmc.2013.09.011
	135367816	164283	0	None	-3	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218801	164283	0	None	-3	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	11483068	84388	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	250	1	1	2	2.0	CCc1cc(Cl)c2c(c1)[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL223440	84388	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	250	1	1	2	2.0	CCc1cc(Cl)c2c(c1)[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	11414184	83085	0	None	-13	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)C2CNCCN12	10.1021/jm0612968
	CHEMBL220274	83085	0	None	-13	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)C2CNCCN12	10.1021/jm0612968
	43922	114267	9	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	250	4	2	2	2.0	COc1cc2c(CCNC(C)=O)c[nH]c2cc1F	10.1021/jm100600y
	CHEMBL333886	114267	9	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	250	4	2	2	2.0	COc1cc2c(CCNC(C)=O)c[nH]c2cc1F	10.1021/jm100600y
	1212	1632	45	None	-27	65	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	204	1632	45	None	-27	65	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	3372	1632	45	None	-27	65	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	CHEMBL726	1632	45	None	-27	65	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	DB00623	1632	45	None	-27	65	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	9856509	95521	4	None	-10	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	259	0	1	1	2.8	Clc1c(Br)ccc2c1CCNCC2	10.1016/j.bmc.2007.12.009
	CHEMBL259480	95521	4	None	-10	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	259	0	1	1	2.8	Clc1c(Br)ccc2c1CCNCC2	10.1016/j.bmc.2007.12.009
	168293016	191512	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	411	7	0	5	5.0	CCCC(C)Oc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	CHEMBL5203303	191512	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	411	7	0	5	5.0	CCCC(C)Oc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	10599545	36172	0	None	-5	3	Human	7.6	pKi	=	7.6	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	447	3	1	3	6.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Cl)c(-c3cccnc3)c1)CC2	10.1021/jm990388c
	CHEMBL14469	36172	0	None	-5	3	Human	7.6	pKi	=	7.6	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	447	3	1	3	6.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Cl)c(-c3cccnc3)c1)CC2	10.1021/jm990388c
	10436045	3460	3	None	-7	13	Human	7.6	pKi	=	7.6	Binding	Binding affinity for 5-hydroxytryptamine 2B receptor was determinedBinding affinity for 5-hydroxytryptamine 2B receptor was determined	ChEMBL	499	9	3	3	6.4	O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2	10.1016/s0960-894x(01)00397-3
	782	3460	3	None	-7	13	Human	7.6	pKi	=	7.6	Binding	Binding affinity for 5-hydroxytryptamine 2B receptor was determinedBinding affinity for 5-hydroxytryptamine 2B receptor was determined	ChEMBL	499	9	3	3	6.4	O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2	10.1016/s0960-894x(01)00397-3
	CHEMBL432713	3460	3	None	-7	13	Human	7.6	pKi	=	7.6	Binding	Binding affinity for 5-hydroxytryptamine 2B receptor was determinedBinding affinity for 5-hydroxytryptamine 2B receptor was determined	ChEMBL	499	9	3	3	6.4	O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2	10.1016/s0960-894x(01)00397-3
	189	3436	31	None	-5	17	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm970741j
	5163	3436	31	None	-5	17	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm970741j
	CHEMBL297784	3436	31	None	-5	17	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm970741j
	11391654	179943	0	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4753511	179943	0	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	189	3436	31	None	-5	17	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cellsDisplacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm970424c
	5163	3436	31	None	-5	17	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cellsDisplacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm970424c
	CHEMBL297784	3436	31	None	-5	17	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cellsDisplacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm970424c
	10835537	38391	0	None	-5	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	413	3	1	3	5.4	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3ccccc3)c1)CC2	10.1021/jm990388c
	CHEMBL14652	38391	0	None	-5	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	413	3	1	3	5.4	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3ccccc3)c1)CC2	10.1021/jm990388c
	10574607	40403	0	None	-7	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	429	3	1	3	6.1	CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3ccncc3)c1)CC2	10.1021/jm990388c
	CHEMBL14841	40403	0	None	-7	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	429	3	1	3	6.1	CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3ccncc3)c1)CC2	10.1021/jm990388c
	44298249	192986	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	394	4	1	4	4.6	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3cccnc3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL53063	192986	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	394	4	1	4	4.6	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3cccnc3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	44298121	193160	0	None	-3	3	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	442	4	1	4	5.3	Cc1cccc(COc2ccc(NC(=O)N3CCc4cc(C)c(C(F)(F)F)cc43)cn2)n1	10.1016/s0960-894x(00)00365-6
	CHEMBL53939	193160	0	None	-3	3	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	442	4	1	4	5.3	Cc1cccc(COc2ccc(NC(=O)N3CCc4cc(C)c(C(F)(F)F)cc43)cn2)n1	10.1016/s0960-894x(00)00365-6
	44214723	193822	0	None	-10	3	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	427	4	1	3	5.6	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ccccn3)cc1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL55335	193822	0	None	-10	3	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	427	4	1	3	5.6	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ccccn3)cc1)CC2	10.1016/s0960-894x(00)00365-6
	1225	1443	24	None	-89	21	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	10.1021/acsmedchemlett.8b00300
	3958	1443	24	None	-89	21	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	10.1021/acsmedchemlett.8b00300
	667477	1443	24	None	-89	21	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	10.1021/acsmedchemlett.8b00300
	CHEMBL860	1443	24	None	-89	21	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	10.1021/acsmedchemlett.8b00300
	DB01142	1443	24	None	-89	21	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	10.1021/acsmedchemlett.8b00300
	20824946	123126	0	None	-7	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	218	1	2	3	0.9	C[C@@H]1CNC[C@H]2Cc3ccc(CO)cc3N12	10.1016/j.bmcl.2005.05.074
	CHEMBL361929	123126	0	None	-7	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	218	1	2	3	0.9	C[C@@H]1CNC[C@H]2Cc3ccc(CO)cc3N12	10.1016/j.bmcl.2005.05.074
	118729244	120174	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(C(F)(F)F)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402662	120174	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(C(F)(F)F)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547029	120174	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(C(F)(F)F)cc2)C1	10.1016/j.bmc.2015.01.060
	122188579	122668	0	None	-1479	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	471	4	4	8	2.0	CCNc1cc(C#Cc2ccc(Cl)s2)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(C(=O)NC)C[C@H]12	10.1021/acsmedchemlett.5b00150
	CHEMBL3612940	122668	0	None	-1479	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	471	4	4	8	2.0	CCNc1cc(C#Cc2ccc(Cl)s2)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(C(=O)NC)C[C@H]12	10.1021/acsmedchemlett.5b00150
	16062137	97263	0	None	-125	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	319	3	1	3	3.5	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL271419	97263	0	None	-125	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	319	3	1	3	3.5	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
	44298186	101241	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	458	4	1	5	5.5	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cnc(Oc3cccnc3C)cc1C)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL299506	101241	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	458	4	1	5	5.5	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cnc(Oc3cccnc3C)cc1C)CC2	10.1016/s0960-894x(00)00364-4
	44298120	193330	0	None	-158	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	438	3	1	4	5.2	Cc1ccc2c(c1Br)CCN2C(=O)Nc1ccc(Oc2cccnc2C)nc1	10.1016/s0960-894x(00)00364-4
	CHEMBL54775	193330	0	None	-158	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	438	3	1	4	5.2	Cc1ccc2c(c1Br)CCN2C(=O)Nc1ccc(Oc2cccnc2C)nc1	10.1016/s0960-894x(00)00364-4
	44323840	204846	0	None	-6	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	586	12	3	9	2.7	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(C(C)=O)cc1	10.1016/S0960-894X(96)00503-3
	CHEMBL88809	204846	0	None	-6	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	586	12	3	9	2.7	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(C(C)=O)cc1	10.1016/S0960-894X(96)00503-3
	155519891	169825	0	None	2	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	249	2	1	4	1.9	COc1cc(OC)c2c(c1)OC[C@@]1(C)NCC[C@@H]21	10.1021/acsmedchemlett.9b00225
	CHEMBL4447975	169825	0	None	2	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	249	2	1	4	1.9	COc1cc(OC)c2c(c1)OC[C@@]1(C)NCC[C@@H]21	10.1021/acsmedchemlett.9b00225
	155526977	170555	0	None	10	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	221	2	1	3	2.3	CC[C@H]1c2cc(OC)ccc2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	CHEMBL4458099	170555	0	None	10	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	221	2	1	3	2.3	CC[C@H]1c2cc(OC)ccc2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	153287541	171629	0	None	-12	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	279	1	0	2	3.9	CN1CC[C@H]2c3cccc(-c4ccccc4)c3OC[C@]21C	10.1021/acsmedchemlett.9b00225
	CHEMBL4473697	171629	0	None	-12	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	279	1	0	2	3.9	CN1CC[C@H]2c3cccc(-c4ccccc4)c3OC[C@]21C	10.1021/acsmedchemlett.9b00225
	153287539	175500	0	None	3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	265	1	1	2	3.6	C[C@@]12COc3ccc(-c4ccccc4)cc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	CHEMBL4591008	175500	0	None	3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	265	1	1	2	3.6	C[C@@]12COc3ccc(-c4ccccc4)cc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	11465413	87615	0	None	-125	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	462	6	0	4	5.7	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCC(C)(C)CC1	10.1016/j.bmcl.2006.10.029
	CHEMBL234494	87615	0	None	-125	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	462	6	0	4	5.7	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCC(C)(C)CC1	10.1016/j.bmcl.2006.10.029
	11305844	87748	0	None	-630	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	466	6	0	4	5.1	COc1ccc(N2Cc3cc(F)cc(C(F)(F)F)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	CHEMBL234739	87748	0	None	-630	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	466	6	0	4	5.1	COc1ccc(N2Cc3cc(F)cc(C(F)(F)F)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	10368204	86337	0	None	-15	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	451	6	0	5	4.6	COc1ccc(N2Cc3c(c4ccc(F)cc4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
	CHEMBL232047	86337	0	None	-15	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	451	6	0	5	4.6	COc1ccc(N2Cc3c(c4ccc(F)cc4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
	2337	3205	72	None	-15	62	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
	50	3205	72	None	-15	62	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
	5002	3205	72	None	-15	62	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
	CHEMBL716	3205	72	None	-15	62	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
	DB01224	3205	72	None	-15	62	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
	76325516	105251	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	280	4	1	3	3.7	O=c1cc(CCCc2ccccc2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
	CHEMBL3126299	105251	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	280	4	1	3	3.7	O=c1cc(CCCc2ccccc2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
	18357724	194922	0	None	-31	3	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	414	4	1	4	4.7	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2ccc(C(F)(F)F)cc21	10.1016/s0960-894x(00)00365-6
	CHEMBL56405	194922	0	None	-31	3	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	414	4	1	4	4.7	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2ccc(C(F)(F)F)cc21	10.1016/s0960-894x(00)00365-6
	162645563	179110	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	348	4	1	3	4.7	O=c1cc(CCCc2ccc(C(F)(F)F)cc2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
	CHEMBL4743625	179110	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	348	4	1	3	4.7	O=c1cc(CCCc2ccc(C(F)(F)F)cc2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
	162648564	179341	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	314	4	1	3	4.3	O=c1cc(CCCc2ccc(Cl)cc2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
	CHEMBL4746138	179341	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	314	4	1	3	4.3	O=c1cc(CCCc2ccc(Cl)cc2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
	162666438	181688	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	298	4	1	3	3.8	O=c1cc(CCCc2cccc(F)c2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
	CHEMBL4783824	181688	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	298	4	1	3	3.8	O=c1cc(CCCc2cccc(F)c2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
	44298126	101124	0	None	-158	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	380	3	1	4	4.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3c(Cl)cccc32)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL298696	101124	0	None	-158	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	380	3	1	4	4.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3c(Cl)cccc32)cn1	10.1016/s0960-894x(00)00364-4
	10085260	170060	0	None	-66	5	Human	6.6	pKi	=	6.6	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]- rauwolscine as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]- rauwolscine as radioligand	ChEMBL	283	1	1	3	2.2	COc1cc(Br)c2c3c1C[C@H](N)C[C@@H]3CO2	10.1021/jm980076u
	CHEMBL445106	170060	0	None	-66	5	Human	6.6	pKi	=	6.6	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]- rauwolscine as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]- rauwolscine as radioligand	ChEMBL	283	1	1	3	2.2	COc1cc(Br)c2c3c1C[C@H](N)C[C@@H]3CO2	10.1021/jm980076u
	71086303	160263	0	None	1	2	Mouse	5.6	pKi	=	5.6	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	373	6	0	5	2.9	Clc1cncc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
	CHEMBL4114493	160263	0	None	1	2	Mouse	5.6	pKi	=	5.6	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	373	6	0	5	2.9	Clc1cncc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
	117209965	184665	1	None	-10	6	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4858338	184665	1	None	-10	6	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	46914775	15256	0	None	3	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	364	7	0	4	4.5	CCCOc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
	CHEMBL1214959	15256	0	None	3	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	364	7	0	4	4.5	CCCOc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
	127035062	135928	0	None	-4	19	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3735756	135928	0	None	-4	19	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	127035062	135928	0	None	-4	19	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3735756	135928	0	None	-4	19	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	15011385	161004	3	None	-1	4	Human	7.6	pKi	=	7.6	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	244	3	1	2	2.6	CN(C)CCc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
	CHEMBL412876	161004	3	None	-1	4	Human	7.6	pKi	=	7.6	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	244	3	1	2	2.6	CN(C)CCc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
	45378936	197825	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	448	5	1	6	4.2	CC(C)Cn1nc2ccc(N3CC[C@@H](N)C3)cc2c1S(=O)(=O)c1cccc2ccccc12	10.1021/jm901674f
	CHEMBL591940	197825	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	448	5	1	6	4.2	CC(C)Cn1nc2ccc(N3CC[C@@H](N)C3)cc2c1S(=O)(=O)c1cccc2ccccc12	10.1021/jm901674f
	70695555	77607	1	None	-14	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	188	0	1	2	1.4	C[C@H]1CNC[C@@H]2Cc3ccccc3N12	10.1016/j.bmcl.2005.05.074
	CHEMBL2096711	77607	1	None	-14	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	188	0	1	2	1.4	C[C@H]1CNC[C@@H]2Cc3ccccc3N12	10.1016/j.bmcl.2005.05.074
	168286277	191019	0	None	-3	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assayDisplacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assay	ChEMBL	468	3	2	3	6.5	Ic1ccc(Nc2nc3ccccc3c3[nH]c(C4CCCCC4)nc23)cc1	10.1021/acs.jmedchem.2c01170
	CHEMBL5195535	191019	0	None	-3	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assayDisplacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assay	ChEMBL	468	3	2	3	6.5	Ic1ccc(Nc2nc3ccccc3c3[nH]c(C4CCCCC4)nc23)cc1	10.1021/acs.jmedchem.2c01170
	1599	2309	47	None	-144	15	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
	3955	2309	47	None	-144	15	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
	7215	2309	47	None	-144	15	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
	CHEMBL841	2309	47	None	-144	15	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
	DB00836	2309	47	None	-144	15	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
	46914771	15237	0	None	12	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	350	6	0	4	4.1	CCOc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
	CHEMBL1214831	15237	0	None	12	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	350	6	0	4	4.1	CCOc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
	165193	3138	60	None	-72	42	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	2303	3138	60	None	-72	42	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	4946	3138	60	None	-72	42	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	564	3138	60	None	-72	42	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	62882	3138	60	None	-72	42	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	63	3138	60	None	-72	42	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	66366	3138	60	None	-72	42	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	91536	3138	60	None	-72	42	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	CHEMBL27	3138	60	None	-72	42	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	CHEMBL452861	3138	60	None	-72	42	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	DB00571	3138	60	None	-72	42	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	4209	3114	71	None	-758	33	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
	4893	3114	71	None	-758	33	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
	503	3114	71	None	-758	33	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
	5385	3114	71	None	-758	33	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
	CHEMBL2	3114	71	None	-758	33	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
	DB00457	3114	71	None	-758	33	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
	10085260	170060	0	None	-66	5	Human	6.6	pKi	=	6.6	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligand	ChEMBL	283	1	1	3	2.2	COc1cc(Br)c2c3c1C[C@H](N)C[C@@H]3CO2	10.1021/jm980076u
	CHEMBL445106	170060	0	None	-66	5	Human	6.6	pKi	=	6.6	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligand	ChEMBL	283	1	1	3	2.2	COc1cc(Br)c2c3c1C[C@H](N)C[C@@H]3CO2	10.1021/jm980076u
	135433933	176464	1	None	-2	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.6	CN1C(=N)N(C)/C(=C/c2c[nH]c3cc(Br)ccc23)C1=O	10.1016/j.bmc.2013.09.011
	CHEMBL463249	176464	1	None	-2	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.6	CN1C(=N)N(C)/C(=C/c2c[nH]c3cc(Br)ccc23)C1=O	10.1016/j.bmc.2013.09.011
	136118728	92629	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3cc(Br)ccc23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2442273	92629	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3cc(Br)ccc23)N1	10.1016/j.bmc.2013.09.011
	90181059	159684	0	None	-1	4	Mouse	5.6	pKi	=	5.6	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	382	6	0	5	2.4	COc1cccc(OC[C@H]2CN(CC(=O)N3CCc4ccccc43)CCO2)c1	nan
	CHEMBL4109801	159684	0	None	-1	4	Mouse	5.6	pKi	=	5.6	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	382	6	0	5	2.4	COc1cccc(OC[C@H]2CN(CC(=O)N3CCc4ccccc43)CCO2)c1	nan
	10472143	118772	0	None	-60	16	Human	7.6	pKi	=	7.6	Binding	Binding affinities towards 5-hydroxytryptamine 2B receptorBinding affinities towards 5-hydroxytryptamine 2B receptor	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	CHEMBL343755	118772	0	None	-60	16	Human	7.6	pKi	=	7.6	Binding	Binding affinities towards 5-hydroxytryptamine 2B receptorBinding affinities towards 5-hydroxytryptamine 2B receptor	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	59757153	105862	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1cccc2c1-c1ccccc1C2	10.1016/j.bmc.2013.10.010
	CHEMBL3092762	105862	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1cccc2c1-c1ccccc1C2	10.1016/j.bmc.2013.10.010
	CHEMBL3139190	105862	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1cccc2c1-c1ccccc1C2	10.1016/j.bmc.2013.10.010
	118464427	137806	0	None	15	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	328	3	4	6	1.8	CCNC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3771331	137806	0	None	15	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	328	3	4	6	1.8	CCNC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	118709750	113041	0	None	-24	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1cccc(F)c1	10.1016/j.bmcl.2014.07.018
	CHEMBL3321791	113041	0	None	-24	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1cccc(F)c1	10.1016/j.bmcl.2014.07.018
	44453652	154917	0	None	4	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	273	1	1	3	2.8	Cc1nc2c(c(-c3ccc(Cl)cc3)n1)CCNCC2	10.1016/j.bmcl.2008.01.090
	CHEMBL403902	154917	0	None	4	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	273	1	1	3	2.8	Cc1nc2c(c(-c3ccc(Cl)cc3)n1)CCNCC2	10.1016/j.bmcl.2008.01.090
	73349361	92116	0	None	-3	7	Human	5.6	pKi	=	5.6	Binding	Inhibition of 5-HT2B receptor (unknown origin) by PDSP assayInhibition of 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	279	4	0	1	3.3	CN(CCc1ccccc1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmc.2013.07.045
	CHEMBL2432058	92116	0	None	-3	7	Human	5.6	pKi	=	5.6	Binding	Inhibition of 5-HT2B receptor (unknown origin) by PDSP assayInhibition of 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	279	4	0	1	3.3	CN(CCc1ccccc1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmc.2013.07.045
	136118636	75961	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	321	1	3	2	2.3	O=C1NC(=S)N/C1=C\c1c[nH]c2cc(Br)ccc12	10.1016/j.bmc.2013.09.011
	CHEMBL2058696	75961	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	321	1	3	2	2.3	O=C1NC(=S)N/C1=C\c1c[nH]c2cc(Br)ccc12	10.1016/j.bmc.2013.09.011
	43229249	140286	1	None	-70	8	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	279	5	0	2	3.7	O=C(CCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818989	140286	1	None	-70	8	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	279	5	0	2	3.7	O=C(CCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2016.05.053
	25067564	199615	0	None	-61	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	392	3	2	5	3.1	N[C@@H]1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
	CHEMBL604102	199615	0	None	-61	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	392	3	2	5	3.1	N[C@@H]1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
	56658157	65338	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	348	7	0	3	4.6	c1ccc(CCCCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
	CHEMBL1834258	65338	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	348	7	0	3	4.6	c1ccc(CCCCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
	43229249	140286	1	None	-70	8	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	279	5	0	2	3.7	O=C(CCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818989	140286	1	None	-70	8	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	279	5	0	2	3.7	O=C(CCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2016.05.053
	44582706	186414	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	417	10	1	5	4.0	COc1ccc(CCN2CCC(C(O)c3cccc(OCCF)c3OC)CC2)cc1	10.1016/j.bmc.2009.03.021
	CHEMBL490633	186414	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	417	10	1	5	4.0	COc1ccc(CCN2CCC(C(O)c3cccc(OCCF)c3OC)CC2)cc1	10.1016/j.bmc.2009.03.021
	3035850	938	65	None	-15135	14	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	544	5	4	9	1.1	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I	10.1021/acs.jmedchem.6b01183
	457	938	65	None	-15135	14	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	544	5	4	9	1.1	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I	10.1021/acs.jmedchem.6b01183
	CHEMBL431733	938	65	None	-15135	14	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	544	5	4	9	1.1	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I	10.1021/acs.jmedchem.6b01183
	DB12885	938	65	None	-15135	14	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	544	5	4	9	1.1	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I	10.1021/acs.jmedchem.6b01183
	145973771	164167	0	None	-3	7	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK293 cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK293 cell membranes after 90 mins by scintillation counting method	ChEMBL	797	16	2	7	10.8	CC(C)(C)OC(=O)NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1	10.1021/acs.jmedchem.8b00168
	CHEMBL4217398	164167	0	None	-3	7	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK293 cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK293 cell membranes after 90 mins by scintillation counting method	ChEMBL	797	16	2	7	10.8	CC(C)(C)OC(=O)NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1	10.1021/acs.jmedchem.8b00168
	21138	97999	34	None	-6	7	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	CC(C)NC[C@@H](O)COc1cccc2ccccc12	nan
	CHEMBL275742	97999	34	None	-6	7	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	CC(C)NC[C@@H](O)COc1cccc2ccccc12	nan
	46914486	15246	0	None	13	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	336	5	0	4	3.8	COc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
	CHEMBL1214894	15246	0	None	13	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	336	5	0	4	3.8	COc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
	124087	1362	106	None	-5	15	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	7157	1362	106	None	-5	15	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	814	1362	106	None	-5	15	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	CHEMBL1172	1362	106	None	-5	15	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	DB00967	1362	106	None	-5	15	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	118055191	176741	0	None	-31	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	280	0	1	2	2.7	CC1(C)CN2CCNCc3ccc(Br)c1c32	10.1016/j.bmcl.2019.126929
	CHEMBL4636977	176741	0	None	-31	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	280	0	1	2	2.7	CC1(C)CN2CCNCc3ccc(Br)c1c32	10.1016/j.bmcl.2019.126929
	CHEMBL5074190	212543	0	None	-112	9	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		COc1ccccc1-c1cc(CCN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	11701315	197609	0	None	1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1ccc2c(c1)N1CCNCC1NC2=O	10.1016/j.bmcl.2009.12.014
	CHEMBL590331	197609	0	None	1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1ccc2c(c1)N1CCNCC1NC2=O	10.1016/j.bmcl.2009.12.014
	44554393	18361	0	None	-61	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	448	5	1	6	4.1	CC(C)Cn1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CCNCC3)ccc21	10.1021/jm1007825
	CHEMBL1275630	18361	0	None	-61	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	448	5	1	6	4.1	CC(C)Cn1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CCNCC3)ccc21	10.1021/jm1007825
	49783415	17496	0	None	-3890	13	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	320	7	1	5	2.9	CCCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1	10.1021/jm100668r
	CHEMBL1258452	17496	0	None	-3890	13	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	320	7	1	5	2.9	CCCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1	10.1021/jm100668r
	136118647	75967	0	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	240	1	3	2	1.2	C/N=C1\NC(=O)/C(=C/c2c[nH]c3ccccc23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2058702	75967	0	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	240	1	3	2	1.2	C/N=C1\NC(=O)/C(=C/c2c[nH]c3ccccc23)N1	10.1016/j.bmc.2013.09.011
	1530	2151	44	None	-19	20	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	3827	2151	44	None	-19	20	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	7206	2151	44	None	-19	20	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	CHEMBL534	2151	44	None	-19	20	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	DB00920	2151	44	None	-19	20	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	122178707	120859	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	395	6	0	5	4.3	COc1cc2c(cc1OCC1CC1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
	CHEMBL3581252	120859	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	395	6	0	5	4.3	COc1cc2c(cc1OCC1CC1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
	11233293	83747	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	310	1	1	2	2.9	CC1(c2cc3c(c(C(F)(F)F)c2)C(=O)N2CCNC[C@@H]32)CC1	10.1021/jm0612968
	CHEMBL220833	83747	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	310	1	1	2	2.9	CC1(c2cc3c(c(C(F)(F)F)c2)C(=O)N2CCNC[C@@H]32)CC1	10.1021/jm0612968
	16115267	84369	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	CHEMBL223272	84369	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	71461049	82562	0	None	-1	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	364	6	0	4	4.9	CCCN1CCC(COc2nc3c(OC)cccc3c3ccccc23)CC1	10.1021/jm300943r
	CHEMBL2181187	82562	0	None	-1	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	364	6	0	4	4.9	CCCN1CCC(COc2nc3c(OC)cccc3c3ccccc23)CC1	10.1021/jm300943r
	56665074	65333	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	350	6	0	4	3.8	COc1cccc(CCN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1016/j.bmcl.2011.08.029
	CHEMBL1834253	65333	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	350	6	0	4	3.8	COc1cccc(CCN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1016/j.bmcl.2011.08.029
	155534799	175938	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor after 60 mins by radiometric scintillation analysisDisplacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor after 60 mins by radiometric scintillation analysis	ChEMBL	416	7	1	6	2.7	O=c1c2cc(Cl)ccc2oc2ccc(CN3CCN(CCOCCO)CC3)cc12	10.1016/j.bmcl.2019.126679
	CHEMBL4471059	175938	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor after 60 mins by radiometric scintillation analysisDisplacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor after 60 mins by radiometric scintillation analysis	ChEMBL	416	7	1	6	2.7	O=c1c2cc(Cl)ccc2oc2ccc(CN3CCN(CCOCCO)CC3)cc12	10.1016/j.bmcl.2019.126679
	CHEMBL4596904	175938	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor after 60 mins by radiometric scintillation analysisDisplacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor after 60 mins by radiometric scintillation analysis	ChEMBL	416	7	1	6	2.7	O=c1c2cc(Cl)ccc2oc2ccc(CN3CCN(CCOCCO)CC3)cc12	10.1016/j.bmcl.2019.126679
	155535203	171475	0	None	-7	6	Human	5.5	pKi	=	5.5	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	403	5	3	7	2.8	O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NC(C3CCC3)C3CCC3)nc(Cl)nc21	10.1021/acs.jmedchem.8b01662
	CHEMBL4471712	171475	0	None	-7	6	Human	5.5	pKi	=	5.5	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	403	5	3	7	2.8	O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NC(C3CCC3)C3CCC3)nc(Cl)nc21	10.1021/acs.jmedchem.8b01662
	5353853	17803	41	None	-23	15	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	9556529	17803	41	None	-23	15	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL1262	17803	41	None	-23	15	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	44409327	76279	0	None	-128	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	261	3	1	4	1.9	CCO[C@@H](C)c1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
	CHEMBL206394	76279	0	None	-128	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	261	3	1	4	1.9	CCO[C@@H](C)c1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
	155531067	171053	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	369	7	3	6	3.3	Nc1nc(NCCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
	CHEMBL4465512	171053	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	369	7	3	6	3.3	Nc1nc(NCCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
	71459604	83379	0	None	-5	14	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	309	4	1	3	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1	10.1016/j.bmcl.2012.08.046
	CHEMBL2205811	83379	0	None	-5	14	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	309	4	1	3	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1	10.1016/j.bmcl.2012.08.046
	122187378	122510	0	None	8	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	455	5	0	5	5.6	COc1cc2c3c(c1OCC1CC1)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	CHEMBL3609143	122510	0	None	8	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	455	5	0	5	5.6	COc1cc2c3c(c1OCC1CC1)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	44455426	154610	0	None	-4	12	Human	6.5	pKi	=	6.5	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL402143	154610	0	None	-4	12	Human	6.5	pKi	=	6.5	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	11288612	182029	0	None	-1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	267	2	1	3	3.0	c1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4788327	182029	0	None	-1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	267	2	1	3	3.0	c1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	145981805	166157	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	313	3	0	2	4.6	CN(C)CC/C=C1\c2ccc(Cl)cc2COc2ccccc21	10.1021/acsmedchemlett.8b00300
	CHEMBL4282729	166157	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	313	3	0	2	4.6	CN(C)CC/C=C1\c2ccc(Cl)cc2COc2ccccc21	10.1021/acsmedchemlett.8b00300
	127048334	140070	0	None	13	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	481	12	0	5	5.8	COc1ccc(CCN(CCCc2ccccc2Cl)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3813796	140070	0	None	13	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	481	12	0	5	5.8	COc1ccc(CCN(CCCc2ccccc2Cl)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	135398737	944	89	None	-2	91	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
	38	944	89	None	-2	91	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
	722	944	89	None	-2	91	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
	CHEMBL42	944	89	None	-2	91	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
	DB00363	944	89	None	-2	91	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
	29943048	67321	0	None	-10	3	Human	8.5	pKi	=	8.5	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	236	0	1	2	2.4	Cc1c(Cl)ccc2c1N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
	CHEMBL190699	67321	0	None	-10	3	Human	8.5	pKi	=	8.5	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	236	0	1	2	2.4	Cc1c(Cl)ccc2c1N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
	29943048	67321	0	None	-10	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	236	0	1	2	2.4	Cc1c(Cl)ccc2c1N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
	CHEMBL190699	67321	0	None	-10	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	236	0	1	2	2.4	Cc1c(Cl)ccc2c1N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
	1588	2294	24	None	-8	43	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	28864	2294	24	None	-8	43	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	43	2294	24	None	-8	43	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	CHEMBL157138	2294	24	None	-8	43	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	DB00589	2294	24	None	-8	43	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	11637931	120072	0	None	-2	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	295	2	2	2	2.0	COC1(C)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3343665	120072	0	None	-2	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	295	2	2	2	2.0	COC1(C)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3545814	120072	0	None	-2	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	295	2	2	2	2.0	COC1(C)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	145993540	166780	0	None	-1	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEKT cells after 90 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEKT cells after 90 mins by scintillation counting method	ChEMBL	503	12	3	11	2.2	NCCCCNC(=O)COc1ccc(CCCn2ncc3c2nc(N)n2nc(-c4ccco4)nc32)cc1	10.1039/C7MD00247E
	CHEMBL4294350	166780	0	None	-1	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEKT cells after 90 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEKT cells after 90 mins by scintillation counting method	ChEMBL	503	12	3	11	2.2	NCCCCNC(=O)COc1ccc(CCCn2ncc3c2nc(N)n2nc(-c4ccco4)nc32)cc1	10.1039/C7MD00247E
	127048335	140062	0	None	15	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	525	12	0	5	5.9	COc1ccc(CCN(CCCc2ccccc2Br)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3813726	140062	0	None	15	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	525	12	0	5	5.9	COc1ccc(CCN(CCCc2ccccc2Br)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	11502243	188916	39	None	-	1	Human	8.5	pKi	=	8.5	Binding	Inhibition of 5-HT2B receptor (unknown origin)Inhibition of 5-HT2B receptor (unknown origin)	ChEMBL	401	4	1	6	4.4	N#Cc1cc(CN2CCC(Nc3ncnc4sc(Cl)cc34)CC2)ccc1F	10.1016/j.bmc.2019.02.044
	CHEMBL513994	188916	39	None	-	1	Human	8.5	pKi	=	8.5	Binding	Inhibition of 5-HT2B receptor (unknown origin)Inhibition of 5-HT2B receptor (unknown origin)	ChEMBL	401	4	1	6	4.4	N#Cc1cc(CN2CCC(Nc3ncnc4sc(Cl)cc34)CC2)ccc1F	10.1016/j.bmc.2019.02.044
	146709966	175206	0	None	338	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2ccc3ccccc3c2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	CHEMBL4583909	175206	0	None	338	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2ccc3ccccc3c2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	72734865	105834	0	None	39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	268	1	3	3	2.0	NC(N)=NC(=O)c1ccc2c(c1)Nc1ccccc1O2	10.1016/j.bmc.2013.10.010
	CHEMBL3092756	105834	0	None	39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	268	1	3	3	2.0	NC(N)=NC(=O)c1ccc2c(c1)Nc1ccccc1O2	10.1016/j.bmc.2013.10.010
	CHEMBL3139103	105834	0	None	39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	268	1	3	3	2.0	NC(N)=NC(=O)c1ccc2c(c1)Nc1ccccc1O2	10.1016/j.bmc.2013.10.010
	135509961	135609	2	None	-3	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	2	4	1.7	C[C@H](N)Cn1ncc2ccc(O)c(Cl)c21	10.1021/jm050663x
	CHEMBL373245	135609	2	None	-3	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	2	4	1.7	C[C@H](N)Cn1ncc2ccc(O)c(Cl)c21	10.1021/jm050663x
	10623020	32184	0	None	-12	2	Human	8.4	pKi	=	8.4	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	441	3	1	3	6.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(C)c(-c3cnccc3C)c1)CC2	10.1021/jm990388c
	CHEMBL14111	32184	0	None	-12	2	Human	8.4	pKi	=	8.4	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	441	3	1	3	6.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(C)c(-c3cnccc3C)c1)CC2	10.1021/jm990388c
	18475630	101426	0	None	19	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	330	2	2	3	4.7	Cc1cc2cc(NC(=O)Nc3ccnc4ccccc34)ccc2n1C	10.1016/s0960-894x(01)00343-2
	CHEMBL300835	101426	0	None	19	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	330	2	2	3	4.7	Cc1cc2cc(NC(=O)Nc3ccnc4ccccc34)ccc2n1C	10.1016/s0960-894x(01)00343-2
	10690185	161205	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	365	3	1	3	4.5	CC(C)Oc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
	CHEMBL41389	161205	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	365	3	1	3	4.5	CC(C)Oc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
	1621	2396	16	None	-19	44	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
	17	2396	16	None	-19	44	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
	5761	2396	16	None	-19	44	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
	CHEMBL263881	2396	16	None	-19	44	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
	DB04829	2396	16	None	-19	44	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
	2600	3720	73	None	-1	13	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	2608	3720	73	None	-1	13	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	5405	3720	73	None	-1	13	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	CHEMBL17157	3720	73	None	-1	13	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	DB00342	3720	73	None	-1	13	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	118729264	120187	0	None	-3	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(Cl)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402675	120187	0	None	-3	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(Cl)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547136	120187	0	None	-3	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(Cl)c2)C1	10.1016/j.bmc.2015.01.060
	118729248	120191	0	None	1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(Br)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402664	120191	0	None	1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(Br)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547150	120191	0	None	1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(Br)cc2)C1	10.1016/j.bmc.2015.01.060
	16062788	97024	0	None	-50	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	333	3	1	3	3.6	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL270188	97024	0	None	-50	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	333	3	1	3	3.6	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	16062781	154640	0	None	-2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	311	2	1	3	3.6	Fc1ccc(-c2nc(C3CCCC3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL402357	154640	0	None	-2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	311	2	1	3	3.6	Fc1ccc(-c2nc(C3CCCC3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	127036932	136824	0	None	1	22	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	274	7	1	1	4.0	C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2015.12.053
	CHEMBL3752900	136824	0	None	1	22	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	274	7	1	1	4.0	C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2015.12.053
	44581973	175028	0	None	-14	10	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	513	6	2	6	4.6	Cc1ccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cc1NC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
	CHEMBL458002	175028	0	None	-14	10	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	513	6	2	6	4.6	Cc1ccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cc1NC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
	73346042	91402	3	None	-3019	17	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	405	9	0	8	0.9	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O	10.1016/j.bmc.2013.05.050
	CHEMBL2413153	91402	3	None	-3019	17	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	405	9	0	8	0.9	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O	10.1016/j.bmc.2013.05.050
	44451429	155226	3	None	-21	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	226	1	1	3	1.9	O=[N+]([O-])c1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
	CHEMBL405829	155226	3	None	-21	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	226	1	1	3	1.9	O=[N+]([O-])c1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
	89901929	120192	0	None	-38	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(Cl)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402665	120192	0	None	-38	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(Cl)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547151	120192	0	None	-38	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(Cl)cc2)C1	10.1016/j.bmc.2015.01.060
	89901938	120201	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccccc2Cl)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402684	120201	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccccc2Cl)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547177	120201	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccccc2Cl)C1	10.1016/j.bmc.2015.01.060
	145978113	163285	0	None	1	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	207	2	1	3	1.9	C[C@@H]1SC(c2ccccc2)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	CHEMBL4206418	163285	0	None	1	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	207	2	1	3	1.9	C[C@@H]1SC(c2ccccc2)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	11312820	135811	0	None	-8	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@H]1CN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2CN1	10.1021/jm0612968
	CHEMBL373402	135811	0	None	-8	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@H]1CN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2CN1	10.1021/jm0612968
	46914621	15247	0	None	5	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	350	6	0	4	4.1	CCOc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
	CHEMBL1214895	15247	0	None	5	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	350	6	0	4	4.1	CCOc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
	122187375	122507	0	None	5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	443	5	0	5	5.6	CCCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	CHEMBL3609140	122507	0	None	5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	443	5	0	5	5.6	CCCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	4211	57517	81	None	-2	4	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	nan
	CHEMBL1670	57517	81	None	-2	4	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	nan
	11737032	84592	0	None	-10	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	222	0	1	2	1.4	O=C1c2c(Cl)cccc2C2CNCCN12	10.1021/jm0612968
	CHEMBL223896	84592	0	None	-10	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	222	0	1	2	1.4	O=C1c2c(Cl)cccc2C2CNCCN12	10.1021/jm0612968
	44316017	203741	0	None	-2	3	Human	7.5	pKi	=	7.5	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	228	2	1	2	2.2	C[C@H](N)CN1CCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL80366	203741	0	None	-2	3	Human	7.5	pKi	=	7.5	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	228	2	1	2	2.2	C[C@H](N)CN1CCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2003.05.001
	6761	67457	17	None	-7	18	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
	CHEMBL1909072	67457	17	None	-7	18	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
	59752584	180913	0	None	1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	323	2	1	3	4.1	CC(C)n1nc2c(c1-c1ccc(Cl)c(Cl)c1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4764808	180913	0	None	1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	323	2	1	3	4.1	CC(C)n1nc2c(c1-c1ccc(Cl)c(Cl)c1)CCNCC2	10.1016/j.bmcl.2020.127669
	118717213	120068	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	323	4	3	2	2.5	CCCCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3343664	120068	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	323	4	3	2	2.5	CCCCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3545802	120068	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	323	4	3	2	2.5	CCCCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	10244831	193218	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	309	3	2	3	4.6	CSc1ccc(NC(=O)Nc2ccnc3ccccc23)cc1	10.1016/s0960-894x(01)00343-2
	CHEMBL54062	193218	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	309	3	2	3	4.6	CSc1ccc(NC(=O)Nc2ccnc3ccccc23)cc1	10.1016/s0960-894x(01)00343-2
	9888804	193321	2	None	-63	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	428	4	1	4	5.0	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ccccn3)nc1)CC2	10.1016/j.bmcl.2005.08.004
	CHEMBL54719	193321	2	None	-63	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	428	4	1	4	5.0	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ccccn3)nc1)CC2	10.1016/j.bmcl.2005.08.004
	10811153	168553	0	None	-7	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	403	3	1	3	5.1	CSc1cc2c(cc1C(F)(F)C(F)(F)F)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
	CHEMBL44015	168553	0	None	-7	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	403	3	1	3	5.1	CSc1cc2c(cc1C(F)(F)C(F)(F)F)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
	44298173	193821	0	None	-31	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	394	3	1	4	5.1	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cnccc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL55331	193821	0	None	-31	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	394	3	1	4	5.1	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cnccc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	44298236	194288	0	None	-19	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	408	3	1	4	5.4	Cc1cc2c(cc1Cl)N(C(=O)Nc1cnc(Oc3cccnc3C)c(C)c1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL55964	194288	0	None	-19	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	408	3	1	4	5.4	Cc1cc2c(cc1Cl)N(C(=O)Nc1cnc(Oc3cccnc3C)c(C)c1)CC2	10.1016/s0960-894x(00)00364-4
	10435572	149567	0	None	-12	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	451	6	0	5	4.6	COc1ccc(N2Cc3c(c4cccc(F)c4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
	CHEMBL395098	149567	0	None	-12	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	451	6	0	5	4.6	COc1ccc(N2Cc3c(c4cccc(F)c4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
	50878551	90314	60	None	-1	18	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	CHEMBL2391541	90314	60	None	-1	18	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	9888804	193321	2	None	-63	3	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	428	4	1	4	5.0	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL54719	193321	2	None	-63	3	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	428	4	1	4	5.0	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	11121216	29925	0	None	-154	14	Human	6.5	pKi	=	6.5	Binding	Binding affinities towards 5-hydroxytryptamine 2B receptorBinding affinities towards 5-hydroxytryptamine 2B receptor	ChEMBL	335	1	1	2	3.0	C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	CHEMBL138989	29925	0	None	-154	14	Human	6.5	pKi	=	6.5	Binding	Binding affinities towards 5-hydroxytryptamine 2B receptorBinding affinities towards 5-hydroxytryptamine 2B receptor	ChEMBL	335	1	1	2	3.0	C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	3845148	65331	1	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	320	5	0	3	3.8	c1ccc(CCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
	CHEMBL1834251	65331	1	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	320	5	0	3	3.8	c1ccc(CCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
	16063181	154894	0	None	-34	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	319	3	1	3	3.5	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CCNC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL403764	154894	0	None	-34	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	319	3	1	3	3.5	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CCNC3)cc1	10.1016/j.bmcl.2008.01.090
	142601337	185388	0	None	-97	5	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4869695	185388	0	None	-97	5	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	145990659	166372	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	273	1	4	6	1.7	NC1=NC2(CCCCC2)NC(Nc2cccc(O)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL4286819	166372	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	273	1	4	6	1.7	NC1=NC2(CCCCC2)NC(Nc2cccc(O)c2)=N1	10.1021/acsmedchemlett.8b00300
	9906447	193904	1	None	-4365	13	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human recombinant 5HT2B receptorBinding affinity to human recombinant 5HT2B receptor	ChEMBL	351	5	0	3	4.8	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1	10.1021/jm201690h
	CHEMBL2031738	193904	1	None	-4365	13	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human recombinant 5HT2B receptorBinding affinity to human recombinant 5HT2B receptor	ChEMBL	351	5	0	3	4.8	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1	10.1021/jm201690h
	CHEMBL555146	193904	1	None	-4365	13	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human recombinant 5HT2B receptorBinding affinity to human recombinant 5HT2B receptor	ChEMBL	351	5	0	3	4.8	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1	10.1021/jm201690h
	9909089	186385	0	None	-2511	7	Human	6.5	pKi	=	6.5	Binding	Binding affinity at 5HT2B receptorBinding affinity at 5HT2B receptor	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
	CHEMBL490417	186385	0	None	-2511	7	Human	6.5	pKi	=	6.5	Binding	Binding affinity at 5HT2B receptorBinding affinity at 5HT2B receptor	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
	10217207	71768	0	None	-398	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	463	7	0	4	5.3	COc1ccc(N2CCN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
	CHEMBL197807	71768	0	None	-398	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	463	7	0	4	5.3	COc1ccc(N2CCN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
	10288601	71840	0	None	-100	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	465	7	0	5	4.2	COc1ccc(N2CCN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCOCC1	10.1016/j.bmcl.2005.08.004
	CHEMBL198007	71840	0	None	-100	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	465	7	0	5	4.2	COc1ccc(N2CCN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCOCC1	10.1016/j.bmcl.2005.08.004
	50898777	56146	0	None	-2951	8	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	441	9	1	6	3.6	COC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1	10.1016/j.bmc.2010.10.011
	CHEMBL1632158	56146	0	None	-2951	8	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	441	9	1	6	3.6	COC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1	10.1016/j.bmc.2010.10.011
	44414105	137657	0	None	-79	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	488	7	0	4	5.9	COc1ccc(N2CC=C(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCC(C)(C)CC1	10.1016/j.bmcl.2006.05.034
	CHEMBL376962	137657	0	None	-79	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	488	7	0	4	5.9	COc1ccc(N2CC=C(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCC(C)(C)CC1	10.1016/j.bmcl.2006.05.034
	19356259	101559	0	None	-158	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.5	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Cl)c(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL301784	101559	0	None	-158	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.5	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Cl)c(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
	44298192	167587	0	None	-100	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	472	3	1	4	4.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(I)ccc32)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL433060	167587	0	None	-100	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	472	3	1	4	4.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(I)ccc32)cn1	10.1016/s0960-894x(00)00364-4
	187	3336	15	None	-288	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	612	11	3	8	3.6	COc1cc(OC)c(cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O)NS(=O)(=O)c1ccc(cc1)C(F)(F)F	10.1016/S0960-894X(96)00503-3
	3693566	3336	15	None	-288	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	612	11	3	8	3.6	COc1cc(OC)c(cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O)NS(=O)(=O)c1ccc(cc1)C(F)(F)F	10.1016/S0960-894X(96)00503-3
	CHEMBL88402	3336	15	None	-288	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	612	11	3	8	3.6	COc1cc(OC)c(cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O)NS(=O)(=O)c1ccc(cc1)C(F)(F)F	10.1016/S0960-894X(96)00503-3
	11766873	205015	0	None	-31	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	558	11	3	8	2.8	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(C)cc1	10.1016/S0960-894X(96)00503-3
	CHEMBL89967	205015	0	None	-31	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	558	11	3	8	2.8	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(C)cc1	10.1016/S0960-894X(96)00503-3
	18931123	205499	0	None	-7	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	601	12	4	9	2.5	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(NC(C)=O)cc1	10.1016/S0960-894X(96)00503-3
	CHEMBL92809	205499	0	None	-7	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	601	12	4	9	2.5	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(NC(C)=O)cc1	10.1016/S0960-894X(96)00503-3
	153287567	171818	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	292	1	1	2	4.3	Cc1ccc(N2C[C@@]3(C)NCC[C@H]3c3cc(C)ccc32)cc1	10.1021/acsmedchemlett.9b00225
	CHEMBL4476396	171818	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	292	1	1	2	4.3	Cc1ccc(N2C[C@@]3(C)NCC[C@H]3c3cc(C)ccc32)cc1	10.1021/acsmedchemlett.9b00225
	153287557	175505	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	420	1	1	2	5.2	C[C@@]12CN(c3ccc(Br)cc3)c3ccc(Br)cc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	CHEMBL4591108	175505	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	420	1	1	2	5.2	C[C@@]12CN(c3ccc(Br)cc3)c3ccc(Br)cc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	11463745	151256	0	None	-79	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	400	6	0	4	4.4	COc1ccc(N2Cc3cccc(Cl)c3C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.10.029
	CHEMBL396505	151256	0	None	-79	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	400	6	0	4	4.4	COc1ccc(N2Cc3cccc(Cl)c3C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.10.029
	11750162	151281	0	None	-100	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	408	6	0	4	4.6	COc1ccc(N2Cc3cc(C)cc(C)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	CHEMBL396527	151281	0	None	-100	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	408	6	0	4	4.6	COc1ccc(N2Cc3cc(C)cc(C)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	179	396	107	None	-17	50	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
	2159	396	107	None	-17	50	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
	963	396	107	None	-17	50	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
	CHEMBL243712	396	107	None	-17	50	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
	DB06288	396	107	None	-17	50	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
	10440	2642	15	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	139030523	2642	15	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	CHEMBL4449712	2642	15	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	155531067	171053	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	369	7	3	6	3.3	Nc1nc(NCCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
	CHEMBL4465512	171053	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	369	7	3	6	3.3	Nc1nc(NCCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
	155558626	174189	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	355	6	3	6	2.9	Nc1nc(NCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
	CHEMBL4561016	174189	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	355	6	3	6	2.9	Nc1nc(NCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
	44243470	88669	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	431	5	1	6	5.5	CC(C)c1cccc(-c2c(-c3ccc4nn(C)cc4c3)nsc2NC(=O)[C@@H]2C[C@H]2C)n1	10.1016/j.bmcl.2013.01.009
	CHEMBL2334981	88669	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	431	5	1	6	5.5	CC(C)c1cccc(-c2c(-c3ccc4nn(C)cc4c3)nsc2NC(=O)[C@@H]2C[C@H]2C)n1	10.1016/j.bmcl.2013.01.009
	CHEMBL2365395	88669	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	431	5	1	6	5.5	CC(C)c1cccc(-c2c(-c3ccc4nn(C)cc4c3)nsc2NC(=O)[C@@H]2C[C@H]2C)n1	10.1016/j.bmcl.2013.01.009
	18931217	205063	0	None	-39	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	623	12	4	10	1.2	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(S(N)(=O)=O)cc1	10.1016/S0960-894X(96)00503-3
	CHEMBL90267	205063	0	None	-39	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	623	12	4	10	1.2	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(S(N)(=O)=O)cc1	10.1016/S0960-894X(96)00503-3
	44439167	90126	0	None	-316	10	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
	CHEMBL238732	90126	0	None	-316	10	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
	71062790	159506	0	None	-	1	Mouse	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	353	6	0	5	2.5	Cc1ncccc1OC[C@H]1CN(CCN2CCc3ccccc32)CCO1	nan
	CHEMBL4108274	159506	0	None	-	1	Mouse	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	353	6	0	5	2.5	Cc1ncccc1OC[C@H]1CN(CCN2CCc3ccccc32)CCO1	nan
	44420683	83718	0	None	-2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	284	0	1	2	2.6	CC1(C)CN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2CN1	10.1021/jm0612968
	CHEMBL220789	83718	0	None	-2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	284	0	1	2	2.6	CC1(C)CN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2CN1	10.1021/jm0612968
	1355	1980	82	None	-1	15	Human	7.5	pKi	=	7.5	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2003.05.001
	142	1980	82	None	-1	15	Human	7.5	pKi	=	7.5	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2003.05.001
	CHEMBL478	1980	82	None	-1	15	Human	7.5	pKi	=	7.5	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2003.05.001
	DB12110	1980	82	None	-1	15	Human	7.5	pKi	=	7.5	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2003.05.001
	11151653	90670	0	None	2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	Cc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397896	90670	0	None	2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	Cc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	1355	1980	82	None	-1	15	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2005.10.029
	142	1980	82	None	-1	15	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2005.10.029
	CHEMBL478	1980	82	None	-1	15	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2005.10.029
	DB12110	1980	82	None	-1	15	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2005.10.029
	CHEMBL5084249	213133	0	None	-38	8	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCN(CC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	1704	3466	76	None	-10	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	356	3	2	3	4.5	O=C(Nc1cc(C)nc2c1cc(F)cc2F)Nc1ccc(cc1)N(C)C	10.1016/j.bmcl.2013.06.057
	4331799	3466	76	None	-10	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	356	3	2	3	4.5	O=C(Nc1cc(C)nc2c1cc(F)cc2F)Nc1ccc(cc1)N(C)C	10.1016/j.bmcl.2013.06.057
	CHEMBL1334465	3466	76	None	-10	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	356	3	2	3	4.5	O=C(Nc1cc(C)nc2c1cc(F)cc2F)Nc1ccc(cc1)N(C)C	10.1016/j.bmcl.2013.06.057
	118055337	176797	0	None	-28	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	220	0	1	2	2.0	CC1(C)CN2CCNCc3ccc(F)c1c32	10.1016/j.bmcl.2019.126929
	CHEMBL4637882	176797	0	None	-28	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	220	0	1	2	2.0	CC1(C)CN2CCNCc3ccc(F)c1c32	10.1016/j.bmcl.2019.126929
	44582675	189109	0	None	-5	15	Human	6.5	pKi	=	6.5	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL515472	189109	0	None	-5	15	Human	6.5	pKi	=	6.5	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	3336	94560	27	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1021/jm100600y
	CHEMBL1405922	94560	27	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1021/jm100600y
	CHEMBL254832	94560	27	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1021/jm100600y
	16573	177045	30	None	-16	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	341	3	1	5	3.2	COc1cc2c(cc1O)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	CHEMBL464099	177045	30	None	-16	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	341	3	1	5	3.2	COc1cc2c(cc1O)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	168273532	189592	0	None	1	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assayDisplacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assay	ChEMBL	450	3	2	3	7.8	Clc1ccc(Nc2nc3ccccc3c3[nH]c([C@@H]4C[C@@H]5CCC[C@@H](C5)C4)nc23)cc1Cl	10.1021/acs.jmedchem.2c01170
	CHEMBL5174205	189592	0	None	1	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assayDisplacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assay	ChEMBL	450	3	2	3	7.8	Clc1ccc(Nc2nc3ccccc3c3[nH]c([C@@H]4C[C@@H]5CCC[C@@H](C5)C4)nc23)cc1Cl	10.1021/acs.jmedchem.2c01170
	23290944	81414	0	None	-213	7	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptor by radioligand binding assayBinding affinity to 5HT2B receptor by radioligand binding assay	ChEMBL	392	6	0	4	3.8	O=C(C1CCCCC1)N(CCN1CCN(c2ccccc2)CC1)c1ccccn1	10.1016/j.bmcl.2012.05.119
	CHEMBL2164350	81414	0	None	-213	7	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptor by radioligand binding assayBinding affinity to 5HT2B receptor by radioligand binding assay	ChEMBL	392	6	0	4	3.8	O=C(C1CCCCC1)N(CCN1CCN(c2ccccc2)CC1)c1ccccn1	10.1016/j.bmcl.2012.05.119
	6075	149575	36	None	-8	16	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
	CHEMBL395110	149575	36	None	-8	16	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
	44247568	81762	51	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	337	5	0	5	3.0	Cc1cc(OCCN2CCOCC2)nn1-c1ccc2ccccc2c1	10.1021/jm3007323
	CHEMBL2170062	81762	51	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	337	5	0	5	3.0	Cc1cc(OCCN2CCOCC2)nn1-c1ccc2ccccc2c1	10.1021/jm3007323
	16118923	59830	0	None	-30	4	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	434	4	3	5	3.5	O=C(Nc1ccc2[nH]nc(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCNCC1	10.1016/j.bmc.2010.10.033
	CHEMBL1642866	59830	0	None	-30	4	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	434	4	3	5	3.5	O=C(Nc1ccc2[nH]nc(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCNCC1	10.1016/j.bmc.2010.10.033
	CHEMBL1739656	59830	0	None	-30	4	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	434	4	3	5	3.5	O=C(Nc1ccc2[nH]nc(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCNCC1	10.1016/j.bmc.2010.10.033
	11695000	88642	0	None	-4	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337490	88642	0	None	-4	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365083	88642	0	None	-4	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	122178706	120858	0	None	1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	425	8	0	5	5.4	CCCCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL3581251	120858	0	None	1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	425	8	0	5	5.4	CCCCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	3038495	700	30	None	-22	19	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm100600y
	7625	700	30	None	-22	19	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm100600y
	CHEMBL25236	700	30	None	-22	19	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm100600y
	11948707	165614	0	None	-83	13	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5HT2B receptor by radioligand binding assayBinding affinity to 5HT2B receptor by radioligand binding assay	ChEMBL	373	7	0	8	0.6	COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1	10.1016/j.bmcl.2006.01.052
	CHEMBL426317	165614	0	None	-83	13	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5HT2B receptor by radioligand binding assayBinding affinity to 5HT2B receptor by radioligand binding assay	ChEMBL	373	7	0	8	0.6	COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1	10.1016/j.bmcl.2006.01.052
	5624	32474	12	None	5	10	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
	CHEMBL1203324	32474	12	None	5	10	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
	CHEMBL141343	32474	12	None	5	10	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
	56675413	65339	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	378	8	0	4	4.6	COc1ccccc1CCCCN1CCN(Cc2cc3ccccc3o2)CC1	10.1016/j.bmcl.2011.08.029
	CHEMBL1834259	65339	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	378	8	0	4	4.6	COc1ccccc1CCCCN1CCN(Cc2cc3ccccc3o2)CC1	10.1016/j.bmcl.2011.08.029
	134143302	144783	0	None	1	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	503	9	5	9	0.6	CC(=O)NCCNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3913293	144783	0	None	1	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	503	9	5	9	0.6	CC(=O)NCCNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	90181065	160265	0	None	5	2	Mouse	6.5	pKi	=	6.5	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	400	5	0	4	3.4	CC1Cc2ccccc2N1C(=O)CN1CCO[C@@H](COc2cccc(Cl)c2)C1	nan
	CHEMBL4114519	160265	0	None	5	2	Mouse	6.5	pKi	=	6.5	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	400	5	0	4	3.4	CC1Cc2ccccc2N1C(=O)CN1CCO[C@@H](COc2cccc(Cl)c2)C1	nan
	155566272	175215	0	None	4	5	Human	6.5	pKi	=	6.5	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	543	8	3	8	5.1	O[C@H]1[C@H](n2cnc3c(NC(C4CCC4)C4CCC4)nc(Cl)nc32)[C@H]2C[C@@]2(CSc2ccccc2F)[C@H]1O	10.1021/acs.jmedchem.8b01662
	CHEMBL4584140	175215	0	None	4	5	Human	6.5	pKi	=	6.5	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	543	8	3	8	5.1	O[C@H]1[C@H](n2cnc3c(NC(C4CCC4)C4CCC4)nc(Cl)nc32)[C@H]2C[C@@]2(CSc2ccccc2F)[C@H]1O	10.1021/acs.jmedchem.8b01662
	CHEMBL5089613	213442	0	None	-3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL		None	None	None		C=C[C@H]1CN2CCc3c([nH]c4cccc(O)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	16115654	136450	0	None	-38	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.1	Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL374562	136450	0	None	-38	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.1	Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	44451373	95888	1	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	187	0	1	2	2.1	c1cc2ccc3c(c2o1)CCNCC3	10.1016/j.bmc.2007.12.009
	CHEMBL261490	95888	1	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	187	0	1	2	2.1	c1cc2ccc3c(c2o1)CCNCC3	10.1016/j.bmc.2007.12.009
	50878551	90314	60	None	-1	18	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	CHEMBL2391541	90314	60	None	-1	18	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	118706296	120014	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	308	2	3	2	1.3	CC(=O)NC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3310119	120014	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	308	2	3	2	1.3	CC(=O)NC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3545441	120014	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	308	2	3	2	1.3	CC(=O)NC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	134143536	144984	0	None	8	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	419	6	4	8	1.7	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@H](C4CCC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3914843	144984	0	None	8	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	419	6	4	8	1.7	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@H](C4CCC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	71459269	82547	0	None	-1479	8	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	555	7	0	4	6.3	Fc1cccc2c1nc(OCC1CCN(CCCc3ccc(I)cc3)CC1)c1cccnc12	10.1021/jm300943r
	CHEMBL2181166	82547	0	None	-1479	8	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	555	7	0	4	6.3	Fc1cccc2c1nc(OCC1CCN(CCCc3ccc(I)cc3)CC1)c1cccnc12	10.1021/jm300943r
	58911532	90673	0	None	-4	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	244	2	1	2	1.6	CCCc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397899	90673	0	None	-4	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	244	2	1	2	1.6	CCCc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	11176570	90689	0	None	-8	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	270	0	1	2	1.7	O=C1c2cc(C(F)(F)F)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397915	90689	0	None	-8	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	270	0	1	2	1.7	O=C1c2cc(C(F)(F)F)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	56661666	65340	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	378	8	0	4	4.6	COc1cccc(CCCCN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1016/j.bmcl.2011.08.029
	CHEMBL1834260	65340	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	378	8	0	4	4.6	COc1cccc(CCCCN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1016/j.bmcl.2011.08.029
	11150514	84453	0	None	-3	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)[C@H]2CNCCN12	10.1021/jm0612968
	CHEMBL223584	84453	0	None	-3	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)[C@H]2CNCCN12	10.1021/jm0612968
	16071847	59829	0	None	-229	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	394	5	3	5	2.8	NCCC(=O)Nc1ccc2[nH]nc(S(=O)(=O)c3cccc4ccccc34)c2c1	10.1016/j.bmc.2010.10.033
	CHEMBL1642865	59829	0	None	-229	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	394	5	3	5	2.8	NCCC(=O)Nc1ccc2[nH]nc(S(=O)(=O)c3cccc4ccccc34)c2c1	10.1016/j.bmc.2010.10.033
	CHEMBL1739655	59829	0	None	-229	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	394	5	3	5	2.8	NCCC(=O)Nc1ccc2[nH]nc(S(=O)(=O)c3cccc4ccccc34)c2c1	10.1016/j.bmc.2010.10.033
	11195293	90657	0	None	1	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@@]12CNCCN1C(=O)c1ccccc1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397883	90657	0	None	1	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@@]12CNCCN1C(=O)c1ccccc1C2	10.1016/j.bmcl.2013.04.061
	90181070	159990	0	None	1	3	Mouse	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	381	5	0	5	2.4	Cc1ccnc(OC[C@H]2CN(CC(=O)N3c4ccccc4CC3C)CCO2)c1	nan
	CHEMBL4112412	159990	0	None	1	3	Mouse	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	381	5	0	5	2.4	Cc1ccnc(OC[C@H]2CN(CC(=O)N3c4ccccc4CC3C)CCO2)c1	nan
	136118621	75900	0	None	5	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.6	CN1C(=N)N(C)/C(=C/c2c[nH]c3c(Br)cccc23)C1=O	10.1016/j.bmc.2013.09.011
	CHEMBL2058420	75900	0	None	5	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.6	CN1C(=N)N(C)/C(=C/c2c[nH]c3c(Br)cccc23)C1=O	10.1016/j.bmc.2013.09.011
	4943	192814	100	None	1	2	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	178	2	1	1	3.6	CC(C)c1cccc(C(C)C)c1O	nan
	CHEMBL526	192814	100	None	1	2	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	178	2	1	1	3.6	CC(C)c1cccc(C(C)C)c1O	nan
	135399666	168198	4	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	191	2	2	4	1.1	C[C@@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL437314	168198	4	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	191	2	2	4	1.1	C[C@@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	46884034	7847	0	None	-870	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	347	3	2	2	3.3	O=C(NCc1ccc(-c2ccc(Cl)cc2)cc1F)N1CCNCC1	10.1016/j.bmcl.2010.01.107
	CHEMBL1090397	7847	0	None	-870	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	347	3	2	2	3.3	O=C(NCc1ccc(-c2ccc(Cl)cc2)cc1F)N1CCNCC1	10.1016/j.bmcl.2010.01.107
	118055294	176900	0	None	-24	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	204	1	1	3	1.2	COc1ccc2c3c1CCN3CCNC2	10.1016/j.bmcl.2019.126929
	CHEMBL4639115	176900	0	None	-24	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	204	1	1	3	1.2	COc1ccc2c3c1CCN3CCNC2	10.1016/j.bmcl.2019.126929
	56682068	65341	0	None	16	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	378	8	0	4	4.6	COc1ccc(CCCCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
	CHEMBL1834261	65341	0	None	16	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	378	8	0	4	4.6	COc1ccc(CCCCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
	4189	205195	91	None	-26	34	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL1559	205195	91	None	-26	34	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL91	205195	91	None	-26	34	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	136118651	75971	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.0	C/N=C1\NC(=O)/C(=C/c2c[nH]c3c(Br)cccc23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2058706	75971	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.0	C/N=C1\NC(=O)/C(=C/c2c[nH]c3c(Br)cccc23)N1	10.1016/j.bmc.2013.09.011
	127052458	140209	0	None	-35	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	5	1	3	3.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818056	140209	0	None	-35	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	5	1	3	3.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1	10.1016/j.bmc.2016.05.053
	9881119	203762	0	None	-9	3	Human	6.5	pKi	=	6.5	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	232	2	1	3	1.7	C[C@H](N)CN1CCc2ccc3c(c21)CCCO3	10.1016/j.bmcl.2003.05.001
	CHEMBL80482	203762	0	None	-9	3	Human	6.5	pKi	=	6.5	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	232	2	1	3	1.7	C[C@H](N)CN1CCc2ccc3c(c21)CCCO3	10.1016/j.bmcl.2003.05.001
	117209864	185452	1	None	-1	6	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4870675	185452	1	None	-1	6	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	127052458	140209	0	None	-35	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	5	1	3	3.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818056	140209	0	None	-35	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	5	1	3	3.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1	10.1016/j.bmc.2016.05.053
	168284710	190997	0	None	-17	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	509	6	0	5	5.8	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccc(Br)cc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL5195241	190997	0	None	-17	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	509	6	0	5	5.8	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccc(Br)cc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	135398745	2869	108	None	-5	65	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
	47	2869	108	None	-5	65	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
	CHEMBL715	2869	108	None	-5	65	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
	DB00334	2869	108	None	-5	65	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
	127035066	135898	0	None	7	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	507	14	0	7	5.2	COc1ccc(OC)c(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
	CHEMBL3735434	135898	0	None	7	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	507	14	0	7	5.2	COc1ccc(OC)c(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
	156021327	177559	0	None	-33	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	224	0	1	3	1.6	Clc1ccc2c3c1OCCN3CCNC2	10.1016/j.bmcl.2019.126929
	CHEMBL4648457	177559	0	None	-33	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	224	0	1	3	1.6	Clc1ccc2c3c1OCCN3CCNC2	10.1016/j.bmcl.2019.126929
	132075278	162094	0	None	-6	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	308	3	0	3	3.1	c1ccc(CN2CCc3cc(N4CCOCC4)ccc3C2)cc1	10.1016/j.ejmech.2018.02.024
	CHEMBL4169752	162094	0	None	-6	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	308	3	0	3	3.1	c1ccc(CN2CCc3cc(N4CCOCC4)ccc3C2)cc1	10.1016/j.ejmech.2018.02.024
	2683	102415	24	None	-501	16	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	CHEMBL305906	102415	24	None	-501	16	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	CHEMBL334255	102415	24	None	-501	16	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	3598	187238	73	None	-2	7	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	nan
	CHEMBL496	187238	73	None	-2	7	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	nan
	136118635	75959	0	None	5	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	321	1	3	2	2.3	O=C1NC(=S)N/C1=C\c1c[nH]c2cccc(Br)c12	10.1016/j.bmc.2013.09.011
	CHEMBL2058694	75959	0	None	5	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	321	1	3	2	2.3	O=C1NC(=S)N/C1=C\c1c[nH]c2cccc(Br)c12	10.1016/j.bmc.2013.09.011
	16115148	84415	0	None	-3	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	206	0	1	2	0.9	O=C1c2c(F)cccc2C2CNCCN12	10.1021/jm0612968
	CHEMBL223469	84415	0	None	-3	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	206	0	1	2	0.9	O=C1c2c(F)cccc2C2CNCCN12	10.1021/jm0612968
	156014235	176604	0	None	-20	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	240	0	1	3	2.4	Clc1ccc2c3c1SCCN3CCNC2	10.1016/j.bmcl.2019.126929
	CHEMBL4634836	176604	0	None	-20	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	240	0	1	3	2.4	Clc1ccc2c3c1SCCN3CCNC2	10.1016/j.bmcl.2019.126929
	53324045	56776	0	None	-9	16	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	487	7	1	2	7.3	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2018.10.036
	CHEMBL1644980	56776	0	None	-9	16	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	487	7	1	2	7.3	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2018.10.036
	11253485	141446	0	None	-3	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	204	0	2	3	0.5	O=C1c2c(O)cccc2C2CNCCN12	10.1021/jm0612968
	CHEMBL387344	141446	0	None	-3	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	204	0	2	3	0.5	O=C1c2c(O)cccc2C2CNCCN12	10.1021/jm0612968
	44409101	140719	0	None	-23	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	233	2	1	4	1.0	COCc1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
	CHEMBL383051	140719	0	None	-23	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	233	2	1	4	1.0	COCc1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
	18735305	203225	0	None	-2	3	Human	7.4	pKi	=	7.4	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	320	2	1	2	2.1	C[C@H](N)CN1CCc2cc(F)c(I)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL76301	203225	0	None	-2	3	Human	7.4	pKi	=	7.4	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	320	2	1	2	2.1	C[C@H](N)CN1CCc2cc(F)c(I)cc21	10.1016/j.bmcl.2003.05.001
	44404883	71718	26	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	218	3	1	3	2.0	CN(C)CCc1cn(C)c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL197664	71718	26	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	218	3	1	3	2.0	CN(C)CCc1cn(C)c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
	44364215	39390	0	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	202	2	2	2	2.0	COc1ccc2[nH]cc(C3CC3N)c2c1	10.1021/jm980318q
	CHEMBL147434	39390	0	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	202	2	2	2	2.0	COc1ccc2[nH]cc(C3CC3N)c2c1	10.1021/jm980318q
	118464425	137781	0	None	3	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	357	3	2	7	2.8	CCOC(=O)c1cccc(NC2=NC(N(C)C)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770981	137781	0	None	3	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	357	3	2	7	2.8	CCOC(=O)c1cccc(NC2=NC(N(C)C)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	145976085	163113	0	None	2	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	CHEMBL4204576	163113	0	None	2	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	44407453	74054	0	None	-9	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	349	5	1	3	5.0	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccccc1Cl	10.1016/j.bmcl.2005.10.029
	CHEMBL202538	74054	0	None	-9	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	349	5	1	3	5.0	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccccc1Cl	10.1016/j.bmcl.2005.10.029
	11163458	136045	0	None	-7	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	298	2	1	2	2.8	CCCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL373905	136045	0	None	-7	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	298	2	1	2	2.8	CCCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	49865831	15985	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	296	2	1	3	3.0	CCCNC(=O)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	CHEMBL1224033	15985	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	296	2	1	3	3.0	CCCNC(=O)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	132060720	161939	0	None	2	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	315	4	0	2	4.9	COc1cccc(-c2ccc3c(c2)CN(Cc2ccccc2)C3)c1	10.1016/j.ejmech.2018.02.024
	CHEMBL4167315	161939	0	None	2	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	315	4	0	2	4.9	COc1cccc(-c2ccc3c(c2)CN(Cc2ccccc2)C3)c1	10.1016/j.ejmech.2018.02.024
	11206703	90661	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@@H]1CNC[C@H]2Cc3ccccc3C(=O)N12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397887	90661	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@@H]1CNC[C@H]2Cc3ccccc3C(=O)N12	10.1016/j.bmcl.2013.04.061
	10528314	171315	0	None	-12	3	Human	7.4	pKi	=	7.4	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	469	3	1	3	6.7	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(C(C)(C)C)c(-c3cccnc3)c1)CC2	10.1021/jm990388c
	CHEMBL446942	171315	0	None	-12	3	Human	7.4	pKi	=	7.4	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	469	3	1	3	6.7	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(C(C)(C)C)c(-c3cccnc3)c1)CC2	10.1021/jm990388c
	240	931	39	None	-6	25	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human serotonin 5-HT2B receptorBinding affinity to human serotonin 5-HT2B receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
	2769	931	39	None	-6	25	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human serotonin 5-HT2B receptorBinding affinity to human serotonin 5-HT2B receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
	44279790	931	39	None	-6	25	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human serotonin 5-HT2B receptorBinding affinity to human serotonin 5-HT2B receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
	660	931	39	None	-6	25	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human serotonin 5-HT2B receptorBinding affinity to human serotonin 5-HT2B receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
	CHEMBL1729	931	39	None	-6	25	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human serotonin 5-HT2B receptorBinding affinity to human serotonin 5-HT2B receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
	CHEMBL560739	931	39	None	-6	25	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human serotonin 5-HT2B receptorBinding affinity to human serotonin 5-HT2B receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
	DB00604	931	39	None	-6	25	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human serotonin 5-HT2B receptorBinding affinity to human serotonin 5-HT2B receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
	18005120	193298	0	None	-100	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	460	4	1	5	5.9	CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL54560	193298	0	None	-100	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	460	4	1	5	5.9	CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	44298086	193549	0	None	-39	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	428	3	1	4	5.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3c2cc(Cl)c(C)c3Cl)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL55079	193549	0	None	-39	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	428	3	1	4	5.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3c2cc(Cl)c(C)c3Cl)cn1	10.1016/s0960-894x(00)00364-4
	44298234	195060	0	None	-25	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	462	3	1	4	6.2	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cnc(Oc3cccnc3C)c(Cl)c1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL56508	195060	0	None	-25	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	462	3	1	4	6.2	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cnc(Oc3cccnc3C)c(Cl)c1)CC2	10.1016/s0960-894x(00)00364-4
	10255548	86336	0	None	-12	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	467	6	0	5	5.1	COc1ccc(N2Cc3c(c4cc(Cl)ccc4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
	CHEMBL232046	86336	0	None	-12	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	467	6	0	5	5.1	COc1ccc(N2Cc3c(c4cc(Cl)ccc4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
	2726	906	64	None	-19	72	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
	621	906	64	None	-19	72	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
	83	906	64	None	-19	72	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
	CHEMBL71	906	64	None	-19	72	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
	DB00477	906	64	None	-19	72	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
	25235287	177142	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	302	0	1	2	4.5	Cc1nccc2c1C(C)(C)Nc1cc(Br)ccc1-2	10.1021/acs.jnatprod.9b01107
	CHEMBL4642292	177142	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	302	0	1	2	4.5	Cc1nccc2c1C(C)(C)Nc1cc(Br)ccc1-2	10.1021/acs.jnatprod.9b01107
	136188797	57024	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	352	3	2	6	2.5	C[C@@H]1SC(c2ccccc2O)=N[C@H]1[C@H]1SC[C@](C)(C(=O)O)N1C	10.1021/acs.jnatprod.7b00317
	CHEMBL1651094	57024	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	352	3	2	6	2.5	C[C@@H]1SC(c2ccccc2O)=N[C@H]1[C@H]1SC[C@](C)(C(=O)O)N1C	10.1021/acs.jnatprod.7b00317
	136030744	57023	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	352	3	2	6	2.5	C[C@@H]1SC(c2ccccc2O)=N[C@H]1[C@@H]1SC[C@](C)(C(=O)O)N1C	10.1021/np100588c
	CHEMBL1651093	57023	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	352	3	2	6	2.5	C[C@@H]1SC(c2ccccc2O)=N[C@H]1[C@@H]1SC[C@](C)(C(=O)O)N1C	10.1021/np100588c
	11288140	84345	0	None	-12	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	213	0	1	3	0.7	N#Cc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	CHEMBL223090	84345	0	None	-12	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	213	0	1	3	0.7	N#Cc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	46830177	7978	29	None	-4365	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	378	6	2	4	3.6	COc1cc(OC2CCC(C)(C)CC2)c(F)cc1CNC(=O)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	CHEMBL1091105	7978	29	None	-4365	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	378	6	2	4	3.6	COc1cc(OC2CCC(C)(C)CC2)c(F)cc1CNC(=O)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	118055319	176952	0	None	-20	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	256	1	1	2	2.6	FC(F)(F)CC1CN2CCNCc3cccc1c32	10.1016/j.bmcl.2019.126929
	CHEMBL4639970	176952	0	None	-20	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	256	1	1	2	2.6	FC(F)(F)CC1CN2CCNCc3cccc1c32	10.1016/j.bmcl.2019.126929
	10050022	165803	0	None	-39	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	462	7	0	4	5.4	COc1ccc(C2CCN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	CHEMBL427398	165803	0	None	-39	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	462	7	0	4	5.4	COc1ccc(C2CCN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	49850870	56095	0	None	-3162	9	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	424	6	1	5	3.3	Cc1ccc2c(N3CCN(CCc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm100714c
	CHEMBL1631535	56095	0	None	-3162	9	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	424	6	1	5	3.3	Cc1ccc2c(N3CCN(CCc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm100714c
	49850570	56178	0	None	-2511	9	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	417	6	2	4	4.0	CCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
	CHEMBL1632220	56178	0	None	-2511	9	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	417	6	2	4	4.0	CCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
	44298140	100093	0	None	-79	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.2	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3ccc(C(F)(F)F)cc32)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL291510	100093	0	None	-79	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.2	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3ccc(C(F)(F)F)cc32)cn1	10.1016/s0960-894x(00)00364-4
	18931172	105693	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	578	11	3	8	3.2	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccccc1Cl	10.1016/S0960-894X(96)00503-3
	CHEMBL313745	105693	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	578	11	3	8	3.2	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccccc1Cl	10.1016/S0960-894X(96)00503-3
	18931163	205048	0	None	-50	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	569	11	3	9	2.4	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(C#N)cc1	10.1016/S0960-894X(96)00503-3
	CHEMBL90175	205048	0	None	-50	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	569	11	3	9	2.4	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(C#N)cc1	10.1016/S0960-894X(96)00503-3
	18931420	205119	0	None	-251	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	628	12	3	9	3.4	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1	10.1016/S0960-894X(96)00503-3
	CHEMBL90565	205119	0	None	-251	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	628	12	3	9	3.4	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1	10.1016/S0960-894X(96)00503-3
	127052465	140200	0	None	-10	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	340	5	0	3	3.6	O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1	10.1016/j.bmc.2016.05.053
	CHEMBL3817911	140200	0	None	-10	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	340	5	0	3	3.6	O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1	10.1016/j.bmc.2016.05.053
	10835585	101391	0	None	-63	3	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	414	4	1	4	4.7	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2cc(C(F)(F)F)ccc21	10.1016/s0960-894x(00)00365-6
	CHEMBL300618	101391	0	None	-63	3	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	414	4	1	4	4.7	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2cc(C(F)(F)F)ccc21	10.1016/s0960-894x(00)00365-6
	1836	2554	56	None	-69	15	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
	3340	2554	56	None	-69	15	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
	5281040	2554	56	None	-69	15	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
	CHEMBL787	2554	56	None	-69	15	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
	DB00471	2554	56	None	-69	15	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
	10597140	62716	0	None	-251	6	Human	5.4	pKi	=	5.4	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandBinding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	400	5	0	3	4.5	CC1CCN(CC[C@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	CHEMBL1788231	62716	0	None	-251	6	Human	5.4	pKi	=	5.4	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandBinding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	400	5	0	3	4.5	CC1CCN(CC[C@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	1703	3463	90	None	-158	6	Human	5.4	pKi	=	5.4	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	319	2	2	5	3.7	O=C(Nc1ccnc2c1nccc2)Nc1ccc2c(c1)oc(n2)C	10.1016/s0960-894x(01)00343-2
	6604926	3463	90	None	-158	6	Human	5.4	pKi	=	5.4	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	319	2	2	5	3.7	O=C(Nc1ccnc2c1nccc2)Nc1ccc2c(c1)oc(n2)C	10.1016/s0960-894x(01)00343-2
	CHEMBL291536	3463	90	None	-158	6	Human	5.4	pKi	=	5.4	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	319	2	2	5	3.7	O=C(Nc1ccnc2c1nccc2)Nc1ccc2c(c1)oc(n2)C	10.1016/s0960-894x(01)00343-2
	44343212	9745	0	None	-100	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor (human cloned receptor) in HEK 293 cells using [3H]5-HT as radioligand.Binding affinity towards 5-hydroxytryptamine 2B receptor (human cloned receptor) in HEK 293 cells using [3H]5-HT as radioligand.	ChEMBL	400	5	0	3	4.5	CC1CCN(CCC2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	CHEMBL114012	9745	0	None	-100	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor (human cloned receptor) in HEK 293 cells using [3H]5-HT as radioligand.Binding affinity towards 5-hydroxytryptamine 2B receptor (human cloned receptor) in HEK 293 cells using [3H]5-HT as radioligand.	ChEMBL	400	5	0	3	4.5	CC1CCN(CCC2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	49865890	16006	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	310	1	1	3	3.5	Cc1ccccc1NC(=O)N1OCC2COc3ccccc3C21	10.1016/j.bmcl.2010.07.074
	CHEMBL1224106	16006	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	310	1	1	3	3.5	Cc1ccccc1NC(=O)N1OCC2COc3ccccc3C21	10.1016/j.bmcl.2010.07.074
	57799324	88663	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	236	0	2	2	1.4	Cc1ccc2c(c1Cl)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337501	88663	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	236	0	2	2	1.4	Cc1ccc2c(c1Cl)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365359	88663	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	236	0	2	2	1.4	Cc1ccc2c(c1Cl)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	11312173	181529	0	None	-3	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	285	2	1	3	3.1	Fc1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4782005	181529	0	None	-3	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	285	2	1	3	3.1	Fc1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	127034715	135871	0	None	35	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	537	15	0	8	5.2	COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3735261	135871	0	None	35	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	537	15	0	8	5.2	COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	107715	199260	18	None	-14	20	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
	CHEMBL1255837	199260	18	None	-14	20	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
	CHEMBL601773	199260	18	None	-14	20	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
	189	3436	31	None	-5	17	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm100600y
	5163	3436	31	None	-5	17	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm100600y
	CHEMBL297784	3436	31	None	-5	17	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm100600y
	11694810	120028	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3310123	120028	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3545474	120028	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	11694810	120028	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3310123	120028	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3545474	120028	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	10531	1392	18	None	-15	24	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	121	1392	18	None	-15	24	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	888	1392	18	None	-15	24	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	CHEMBL1732	1392	18	None	-15	24	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	DB00320	1392	18	None	-15	24	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	118706301	120027	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	265	1	2	1	2.2	CC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3310122	120027	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	265	1	2	1	2.2	CC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3545473	120027	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	265	1	2	1	2.2	CC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	168293874	191581	0	None	5	11	Human	8.4	pKi	=	8.4	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5204071	191581	0	None	5	11	Human	8.4	pKi	=	8.4	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	145988313	166682	0	None	104	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting methodDisplacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting method	ChEMBL	451	6	2	2	5.0	O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1039/C8MD00204E
	CHEMBL4292326	166682	0	None	104	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting methodDisplacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting method	ChEMBL	451	6	2	2	5.0	O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1039/C8MD00204E
	168268877	189377	0	None	1	12	Human	8.3	pKi	=	8.3	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5170784	189377	0	None	1	12	Human	8.3	pKi	=	8.3	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	127035064	135948	0	None	23	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	477	13	0	6	5.2	COc1cccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
	CHEMBL3735911	135948	0	None	23	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	477	13	0	6	5.2	COc1cccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
	135	2496	38	None	-3	57	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	1796	2496	38	None	-3	57	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	4184	2496	38	None	-3	57	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	CHEMBL6437	2496	38	None	-3	57	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	DB06148	2496	38	None	-3	57	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	11681111	120073	0	None	-7	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	309	3	2	2	2.4	CCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3343666	120073	0	None	-7	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	309	3	2	2	2.4	CCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3545815	120073	0	None	-7	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	309	3	2	2	2.4	CCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	16062783	154483	0	None	2	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	323	3	1	4	3.5	COc1ccc(-c2nc(C3CCCC3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL401509	154483	0	None	2	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	323	3	1	4	3.5	COc1ccc(-c2nc(C3CCCC3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	14049689	196766	8	None	20	2	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	1541	28	21	42	-12.4	CC(O)COC[C@H]1O[C@@H]2O[C@@H]3[C@@H](COCC(C)O)O[C@H](O[C@@H]4[C@@H](COCC(C)O)O[C@H](O[C@@H]5[C@@H](COCC(C)O)O[C@H](O[C@@H]6[C@@H](COCC(C)O)O[C@H](O[C@@H]7[C@@H](COCC(C)O)O[C@H](O[C@@H]8[C@@H](COCC(C)O)O[C@H](O[C@H]1[C@H](O)[C@H]2O)[C@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O	nan
	CHEMBL577294	196766	8	None	20	2	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	1541	28	21	42	-12.4	CC(O)COC[C@H]1O[C@@H]2O[C@@H]3[C@@H](COCC(C)O)O[C@H](O[C@@H]4[C@@H](COCC(C)O)O[C@H](O[C@@H]5[C@@H](COCC(C)O)O[C@H](O[C@@H]6[C@@H](COCC(C)O)O[C@H](O[C@@H]7[C@@H](COCC(C)O)O[C@H](O[C@@H]8[C@@H](COCC(C)O)O[C@H](O[C@H]1[C@H](O)[C@H]2O)[C@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O	nan
	58911653	90685	0	None	2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	244	1	1	2	1.5	CCc1cc(C)c2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397911	90685	0	None	2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	244	1	1	2	1.5	CCc1cc(C)c2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	57799306	88680	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337493	88680	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365469	88680	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
	9899500	67547	0	None	-14	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	236	0	1	2	2.4	Cc1c(Cl)ccc2c1N1[C@H](CNC[C@H]1C)C2	10.1016/j.bmcl.2005.11.083
	CHEMBL191054	67547	0	None	-14	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	236	0	1	2	2.4	Cc1c(Cl)ccc2c1N1[C@H](CNC[C@H]1C)C2	10.1016/j.bmcl.2005.11.083
	168281367	190307	0	None	2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	395	6	0	5	4.3	COc1cc2c(cc1OC)-c1c(OC)c(OCC3CC3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL5185086	190307	0	None	2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	395	6	0	5	4.3	COc1cc2c(cc1OC)-c1c(OC)c(OCC3CC3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	118729232	120163	0	None	9	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	5.0	CN(C)[C@H]1Cc2ccccc2[C@H](C2CCCCCCC2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402655	120163	0	None	9	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	5.0	CN(C)[C@H]1Cc2ccccc2[C@H](C2CCCCCCC2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547008	120163	0	None	9	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	5.0	CN(C)[C@H]1Cc2ccccc2[C@H](C2CCCCCCC2)C1	10.1016/j.bmc.2015.01.060
	90188146	120186	0	None	1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(Br)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402674	120186	0	None	1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(Br)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547135	120186	0	None	1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(Br)c2)C1	10.1016/j.bmc.2015.01.060
	16062912	154613	0	None	-56	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	351	3	1	3	3.7	Fc1ccc(Cc2nc3c(c(-c4ccc(F)cc4)n2)CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL402164	154613	0	None	-56	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	351	3	1	3	3.7	Fc1ccc(Cc2nc3c(c(-c4ccc(F)cc4)n2)CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	71461050	82564	0	None	-13	5	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	352	5	0	3	5.0	CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1	10.1021/jm300943r
	CHEMBL2181189	82564	0	None	-13	5	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	352	5	0	3	5.0	CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1	10.1021/jm300943r
	45486891	195265	0	None	-83	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	449	6	3	4	4.1	O=C1Cc2c(ccc3c2OC[C@H](CNCCCC2CCc4c([nH]c5ccc(F)cc45)C2)O3)N1	10.1016/j.bmcl.2009.08.050
	CHEMBL566379	195265	0	None	-83	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	449	6	3	4	4.1	O=C1Cc2c(ccc3c2OC[C@H](CNCCCC2CCc4c([nH]c5ccc(F)cc45)C2)O3)N1	10.1016/j.bmcl.2009.08.050
	145974750	164203	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	223	2	2	4	1.6	C[C@H]1SC(c2ccccc2O)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	CHEMBL4217810	164203	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	223	2	2	4	1.6	C[C@H]1SC(c2ccccc2O)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	127052465	140200	0	None	-10	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	340	5	0	3	3.6	O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1	10.1016/j.bmc.2016.05.053
	CHEMBL3817911	140200	0	None	-10	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	340	5	0	3	3.6	O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1	10.1016/j.bmc.2016.05.053
	89901924	120194	0	None	-100	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(F)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402667	120194	0	None	-100	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(F)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547153	120194	0	None	-100	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(F)cc2)C1	10.1016/j.bmc.2015.01.060
	16062651	95201	0	None	-13	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	285	3	1	3	3.1	CC(C)Cc1nc2c(c(-c3ccc(F)cc3)n1)CNCC2	10.1016/j.bmcl.2008.01.090
	CHEMBL257944	95201	0	None	-13	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	285	3	1	3	3.1	CC(C)Cc1nc2c(c(-c3ccc(F)cc3)n1)CNCC2	10.1016/j.bmcl.2008.01.090
	132007291	148413	0	None	-33	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	395	3	2	4	4.3	Fc1ccc(C#Cc2nc(NCc3cccc(Cl)c3)c3nc[nH]c3n2)cc1F	10.1021/acs.jmedchem.6b01183
	CHEMBL3941980	148413	0	None	-33	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	395	3	2	4	4.3	Fc1ccc(C#Cc2nc(NCc3cccc(Cl)c3)c3nc[nH]c3n2)cc1F	10.1021/acs.jmedchem.6b01183
	1782	2482	81	None	-3	22	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
	241	2482	81	None	-3	22	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
	4168	2482	81	None	-3	22	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
	CHEMBL86	2482	81	None	-3	22	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
	DB01233	2482	81	None	-3	22	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
	11171955	90662	0	None	-1	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.2	C[C@@H]1c2ccccc2C(=O)N2CCNC[C@@H]12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397888	90662	0	None	-1	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.2	C[C@@H]1c2ccccc2C(=O)N2CCNC[C@@H]12	10.1016/j.bmcl.2013.04.061
	16115515	137071	0	None	-3	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	290	0	1	2	2.5	O=C1c2c(C(F)(F)F)ccc(Cl)c2[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL375575	137071	0	None	-3	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	290	0	1	2	2.5	O=C1c2c(C(F)(F)F)ccc(Cl)c2[C@@H]2CNCCN12	10.1021/jm0612968
	2775690	92579	47	None	-15	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5-HT2B receptor (unknown origin)Binding affinity to 5-HT2B receptor (unknown origin)	ChEMBL	295	1	1	3	3.0	Cc1ccc2nc(C(F)(F)F)cc(N3CCNCC3)c2c1	10.1021/ml400312j
	CHEMBL2441619	92579	47	None	-15	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5-HT2B receptor (unknown origin)Binding affinity to 5-HT2B receptor (unknown origin)	ChEMBL	295	1	1	3	3.0	Cc1ccc2nc(C(F)(F)F)cc(N3CCNCC3)c2c1	10.1021/ml400312j
	11848624	88716	0	None	2	6	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	381	7	1	6	4.3	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1OC	10.1016/j.bmcl.2009.09.024
	CHEMBL236587	88716	0	None	2	6	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	381	7	1	6	4.3	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1OC	10.1016/j.bmcl.2009.09.024
	46230100	197639	0	None	-2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	231	0	2	3	0.9	Cc1ccc2c(c1)N1CCNCCC1NC2=O	10.1016/j.bmcl.2009.12.014
	CHEMBL590531	197639	0	None	-2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	231	0	2	3	0.9	Cc1ccc2c(c1)N1CCNCCC1NC2=O	10.1016/j.bmcl.2009.12.014
	118717211	120067	0	None	-33	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	295	2	3	2	1.7	CCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3343663	120067	0	None	-33	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	295	2	3	2	1.7	CCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3545801	120067	0	None	-33	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	295	2	3	2	1.7	CCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	44451422	166871	2	None	-9	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	199	0	1	1	2.2	Fc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
	CHEMBL429689	166871	2	None	-9	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	199	0	1	1	2.2	Fc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
	75201901	165872	14	None	-301	24	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4277264	165872	14	None	-301	24	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	118729238	120167	0	None	-52	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccccc2Br)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402659	120167	0	None	-52	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccccc2Br)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547012	120167	0	None	-52	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccccc2Br)C1	10.1016/j.bmc.2015.01.060
	118729240	120168	0	None	-6	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	296	3	0	3	3.6	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc([N+](=O)[O-])cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402660	120168	0	None	-6	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	296	3	0	3	3.6	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc([N+](=O)[O-])cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547013	120168	0	None	-6	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	296	3	0	3	3.6	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc([N+](=O)[O-])cc2)C1	10.1016/j.bmc.2015.01.060
	46884098	8103	0	None	-954	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	286	4	2	2	3.1	O=C(NCc1ccc(C2CCCCC2)cc1)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	CHEMBL1092029	8103	0	None	-954	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	286	4	2	2	3.1	O=C(NCc1ccc(C2CCCCC2)cc1)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	142601329	185935	3	None	-63	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4877603	185935	3	None	-63	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	122187379	122511	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	441	5	0	5	5.3	C=CCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	CHEMBL3609144	122511	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	441	5	0	5	5.3	C=CCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	122483223	137581	0	None	-5	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764650	137581	0	None	-5	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765874	137581	0	None	-5	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	122187382	122513	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	429	4	0	5	5.2	CCN1CC(c2ccccc2)c2cc(OC)c(OC)c3c2C1Cc1cc2c(cc1-3)OCO2	10.1016/j.bmcl.2015.07.012
	CHEMBL3609147	122513	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	429	4	0	5	5.2	CCN1CC(c2ccccc2)c2cc(OC)c(OC)c3c2C1Cc1cc2c(cc1-3)OCO2	10.1016/j.bmcl.2015.07.012
	137646281	157264	0	None	-95	17	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	423	8	0	7	3.8	COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1	10.1021/acs.jmedchem.9b00412
	CHEMBL4083252	157264	0	None	-95	17	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	423	8	0	7	3.8	COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1	10.1021/acs.jmedchem.9b00412
	122178711	120863	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	509	6	0	5	5.8	COc1cc2c(cc1OCc1ccc(Br)cc1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
	CHEMBL3581256	120863	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	509	6	0	5	5.8	COc1cc2c(cc1OCc1ccc(Br)cc1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
	46933845	15986	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	336	1	1	3	3.9	O=C(NC1CCCCC1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	CHEMBL1224034	15986	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	336	1	1	3	3.9	O=C(NC1CCCCC1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	11957541	1430	38	None	-1	15	Human	7.4	pKi	=	7.4	Binding	Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm9803525
	1229	1430	38	None	-1	15	Human	7.4	pKi	=	7.4	Binding	Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm9803525
	147	1430	38	None	-1	15	Human	7.4	pKi	=	7.4	Binding	Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm9803525
	170617	1430	38	None	-1	15	Human	7.4	pKi	=	7.4	Binding	Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm9803525
	CHEMBL6616	1430	38	None	-1	15	Human	7.4	pKi	=	7.4	Binding	Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm9803525
	25117676	198775	0	None	-831	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	420	4	1	5	3.7	CN(C)[C@@H]1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
	CHEMBL598444	198775	0	None	-831	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	420	4	1	5	3.7	CN(C)[C@@H]1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
	53325242	56775	0	None	-2	17	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	537	8	1	2	7.9	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	CHEMBL1644978	56775	0	None	-2	17	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	537	8	1	2	7.9	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	21854226	124084	4	None	-1	3	Human	6.4	pKi	=	6.4	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	230	3	2	2	2.5	Oc1cccc2[nH]cc(CCN3CCCC3)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL364061	124084	4	None	-1	3	Human	6.4	pKi	=	6.4	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	230	3	2	2	2.5	Oc1cccc2[nH]cc(CCN3CCCC3)c12	10.1016/j.bmcl.2005.06.104
	2286	3134	48	None	-5	29	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	4927	3134	48	None	-5	29	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	7282	3134	48	None	-5	29	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	CHEMBL643	3134	48	None	-5	29	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	DB01069	3134	48	None	-5	29	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	59752589	179246	0	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	323	2	1	3	4.1	CC(C)n1nc2c(c1-c1ccc(Cl)cc1Cl)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4745055	179246	0	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	323	2	1	3	4.1	CC(C)n1nc2c(c1-c1ccc(Cl)cc1Cl)CCNCC2	10.1016/j.bmcl.2020.127669
	11425677	181753	0	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	269	1	1	3	3.0	CC(C)(C)n1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4784424	181753	0	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	269	1	1	3	3.0	CC(C)(C)n1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
	145975946	163368	0	None	-2	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	307	8	1	4	3.9	CCCCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1	10.1021/acs.jnatprod.7b00317
	CHEMBL4207355	163368	0	None	-2	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	307	8	1	4	3.9	CCCCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1	10.1021/acs.jnatprod.7b00317
	2406	99938	84	None	-27	12	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	nan
	CHEMBL290106	99938	84	None	-27	12	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	nan
	3198	203802	73	None	-30	34	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL1201049	203802	73	None	-30	34	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL808	203802	73	None	-30	34	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	118055192	176459	0	None	-46	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	188	0	1	2	1.7	CC1CN2CCNCc3cccc1c32	10.1016/j.bmcl.2019.126929
	CHEMBL4632419	176459	0	None	-46	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	188	0	1	2	1.7	CC1CN2CCNCc3cccc1c32	10.1016/j.bmcl.2019.126929
	10947658	28490	0	None	-39	16	Human	7.4	pKi	=	7.4	Binding	Binding affinities against 5-hydroxytryptamine 2B receptorBinding affinities against 5-hydroxytryptamine 2B receptor	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	CHEMBL137781	28490	0	None	-39	16	Human	7.4	pKi	=	7.4	Binding	Binding affinities against 5-hydroxytryptamine 2B receptorBinding affinities against 5-hydroxytryptamine 2B receptor	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	44409095	75677	0	None	-4	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	219	1	1	4	0.8	COc1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
	CHEMBL205671	75677	0	None	-4	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	219	1	1	4	0.8	COc1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
	71618702	142850	0	None	1	4	Mouse	6.4	pKi	=	6.4	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	400	5	0	4	3.4	CC1Cc2ccccc2N1C(=O)CN1CCO[C@H](COc2cccc(Cl)c2)C1	nan
	CHEMBL3897835	142850	0	None	1	4	Mouse	6.4	pKi	=	6.4	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	400	5	0	4	3.4	CC1Cc2ccccc2N1C(=O)CN1CCO[C@H](COc2cccc(Cl)c2)C1	nan
	156014421	176631	0	None	-12	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	256	0	1	3	1.4	[O-][S+]1CCN2CCNCc3ccc(Cl)c1c32	10.1016/j.bmcl.2019.126929
	CHEMBL4635293	176631	0	None	-12	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	256	0	1	3	1.4	[O-][S+]1CCN2CCNCc3ccc(Cl)c1c32	10.1016/j.bmcl.2019.126929
	25122654	198844	0	None	-54	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	390	3	2	5	3.0	NC1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc(Cl)c4)c3c2)CC1	10.1021/jm901674f
	CHEMBL598851	198844	0	None	-54	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	390	3	2	5	3.0	NC1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc(Cl)c4)c3c2)CC1	10.1021/jm901674f
	135476741	154985	9	None	-7	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	254	1	2	2	1.8	CN1C(=N)N(C)/C(=C/c2c[nH]c3ccccc23)C1=O	10.1016/j.bmc.2013.09.011
	CHEMBL404232	154985	9	None	-7	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	254	1	2	2	1.8	CN1C(=N)N(C)/C(=C/c2c[nH]c3ccccc23)C1=O	10.1016/j.bmc.2013.09.011
	117209962	184286	1	None	-16	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4852622	184286	1	None	-16	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	136118716	92627	0	None	-3	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3cccc(Br)c23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2442271	92627	0	None	-3	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3cccc(Br)c23)N1	10.1016/j.bmc.2013.09.011
	180	397	50	None	-35	38	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	200	397	50	None	-35	38	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	2160	397	50	None	-35	38	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	CHEMBL629	397	50	None	-35	38	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	DB00321	397	50	None	-35	38	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	122178703	120855	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	383	5	0	5	4.3	COc1cc2c(cc1OC(C)C)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
	CHEMBL3581248	120855	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	383	5	0	5	4.3	COc1cc2c(cc1OC(C)C)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
	127049980	140103	0	None	4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	525	12	0	5	5.9	COc1ccc(CCN(CCCc2ccc(Br)cc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3814485	140103	0	None	4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	525	12	0	5	5.9	COc1ccc(CCN(CCCc2ccc(Br)cc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	134144970	150240	0	None	4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	461	8	3	9	2.3	CCCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3956531	150240	0	None	4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	461	8	3	9	2.3	CCCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	12901777	137471	26	None	-7	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	188	0	1	2	0.8	O=C1c2ccccc2C2CNCCN12	10.1021/jm0612968
	CHEMBL376455	137471	26	None	-7	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	188	0	1	2	0.8	O=C1c2ccccc2C2CNCCN12	10.1021/jm0612968
	44407337	73856	0	None	-5	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	265	5	1	3	3.4	C=CCN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL202324	73856	0	None	-5	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	265	5	1	3	3.4	C=CCN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	45378934	199961	0	None	-8	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	406	3	1	6	3.1	Cn1nc2ccc(N3CC[C@@H](N)C3)cc2c1S(=O)(=O)c1cccc2ccccc12	10.1021/jm901674f
	CHEMBL605971	199961	0	None	-8	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	406	3	1	6	3.1	Cn1nc2ccc(N3CC[C@@H](N)C3)cc2c1S(=O)(=O)c1cccc2ccccc12	10.1021/jm901674f
	135449090	188725	3	None	-2	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	268	1	1	2	1.9	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3ccccc23)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL512332	188725	3	None	-2	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	268	1	1	2	1.9	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3ccccc23)N1C	10.1016/j.bmc.2013.09.011
	4595	176141	102	None	2	15	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	nan
	CHEMBL46	176141	102	None	2	15	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	nan
	136118729	92630	0	None	-4	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3c(Br)cccc23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2442274	92630	0	None	-4	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3c(Br)cccc23)N1	10.1016/j.bmc.2013.09.011
	10150497	4011	41	None	-223	4	Human	6.3	pKi	=	6.3	Binding	Inhibition of human 5HT2B receptor expressed in CHO cellsInhibition of human 5HT2B receptor expressed in CHO cells	ChEMBL	380	4	1	7	2.7	NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2	10.1021/jm070521y
	3240	4011	41	None	-223	4	Human	6.3	pKi	=	6.3	Binding	Inhibition of human 5HT2B receptor expressed in CHO cellsInhibition of human 5HT2B receptor expressed in CHO cells	ChEMBL	380	4	1	7	2.7	NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2	10.1021/jm070521y
	CHEMBL392760	4011	41	None	-223	4	Human	6.3	pKi	=	6.3	Binding	Inhibition of human 5HT2B receptor expressed in CHO cellsInhibition of human 5HT2B receptor expressed in CHO cells	ChEMBL	380	4	1	7	2.7	NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2	10.1021/jm070521y
	168	3919	11	None	-3	3	Human	7.3	pKi	=	7.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
	6604042	3919	11	None	-3	3	Human	7.3	pKi	=	7.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
	CHEMBL309760	3919	11	None	-3	3	Human	7.3	pKi	=	7.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
	10430183	203916	0	None	-457	7	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human 5-HT2B receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human 5-HT2B receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	385	5	1	5	2.1	O=C(NCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccc(F)cc1	10.1021/acs.jmedchem.2c00633
	CHEMBL81728	203916	0	None	-457	7	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human 5-HT2B receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human 5-HT2B receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	385	5	1	5	2.1	O=C(NCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccc(F)cc1	10.1021/acs.jmedchem.2c00633
	118055338	176611	0	None	-57	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	222	0	1	2	2.4	CC1CN2CCNCc3ccc(Cl)c1c32	10.1016/j.bmcl.2019.126929
	CHEMBL4634942	176611	0	None	-57	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	222	0	1	2	2.4	CC1CN2CCNCc3ccc(Cl)c1c32	10.1016/j.bmcl.2019.126929
	56852956	111551	1	None	-12	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by PDSP assayDisplacement of [3H]LSD from human 5-HT2B receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
	CHEMBL3289656	111551	1	None	-12	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by PDSP assayDisplacement of [3H]LSD from human 5-HT2B receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
	71618636	148353	0	None	-7	2	Mouse	5.3	pKi	=	5.3	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	381	5	0	5	2.4	Cc1ncccc1OC[C@@H]1CN(CC(=O)N2c3ccccc3CC2C)CCO1	nan
	CHEMBL3941579	148353	0	None	-7	2	Mouse	5.3	pKi	=	5.3	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	381	5	0	5	2.4	Cc1ncccc1OC[C@@H]1CN(CC(=O)N2c3ccccc3CC2C)CCO1	nan
	56665075	65334	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	350	6	0	4	3.8	COc1ccc(CCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
	CHEMBL1834254	65334	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	350	6	0	4	3.8	COc1ccc(CCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
	1547484	927	70	None	-8	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	654	927	70	None	-8	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	9072	927	70	None	-8	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	CHEMBL43064	927	70	None	-8	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	DB00568	927	70	None	-8	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	44582678	180992	0	None	-3	10	Human	6.3	pKi	=	6.3	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	401	9	1	4	4.3	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL476839	180992	0	None	-3	10	Human	6.3	pKi	=	6.3	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	401	9	1	4	4.3	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
	136188797	57024	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	352	3	2	6	2.5	C[C@@H]1SC(c2ccccc2O)=N[C@H]1[C@H]1SC[C@](C)(C(=O)O)N1C	10.1021/np100588c
	CHEMBL1651094	57024	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	352	3	2	6	2.5	C[C@@H]1SC(c2ccccc2O)=N[C@H]1[C@H]1SC[C@](C)(C(=O)O)N1C	10.1021/np100588c
	102	4064	44	None	-93	49	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
	3659	4064	44	None	-93	49	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
	8969	4064	44	None	-93	49	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
	CHEMBL15245	4064	44	None	-93	49	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
	DB01392	4064	44	None	-93	49	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
	24826787	90666	0	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	270	0	1	2	1.7	O=C1c2c(cccc2C(F)(F)F)C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397892	90666	0	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	270	0	1	2	1.7	O=C1c2c(cccc2C(F)(F)F)C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	24826869	90671	0	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	1	1	2	1.2	CCc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397897	90671	0	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	1	1	2	1.2	CCc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	145964159	163777	0	None	3	6	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	273	3	2	4	2.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	CHEMBL4212435	163777	0	None	3	6	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	273	3	2	4	2.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	168281307	190212	0	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	411	8	0	5	5.0	CCCCCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	CHEMBL5183799	190212	0	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	411	8	0	5	5.0	CCCCCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	56852956	111551	1	None	-12	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by PDSP assayDisplacement of [3H]LSD from human 5-HT2B receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
	CHEMBL3289656	111551	1	None	-12	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by PDSP assayDisplacement of [3H]LSD from human 5-HT2B receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
	11347858	136513	0	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	286	1	2	3	1.3	O=C1c2c(cc(CO)cc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL374659	136513	0	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	286	1	2	3	1.3	O=C1c2c(cc(CO)cc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	136030744	57023	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	352	3	2	6	2.5	C[C@@H]1SC(c2ccccc2O)=N[C@H]1[C@@H]1SC[C@](C)(C(=O)O)N1C	10.1021/acs.jnatprod.7b00317
	CHEMBL1651093	57023	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	352	3	2	6	2.5	C[C@@H]1SC(c2ccccc2O)=N[C@H]1[C@@H]1SC[C@](C)(C(=O)O)N1C	10.1021/acs.jnatprod.7b00317
	134149008	147929	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	353	3	3	8	-0.1	CN(C)c1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(C(=O)O)C[C@H]12	10.1021/acs.jmedchem.6b01183
	CHEMBL3938006	147929	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	353	3	3	8	-0.1	CN(C)c1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(C(=O)O)C[C@H]12	10.1021/acs.jmedchem.6b01183
	16115521	84242	0	None	3	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	252	1	1	3	1.4	COc1cc2c(cc1Cl)[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL222466	84242	0	None	3	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	252	1	1	3	1.4	COc1cc2c(cc1Cl)[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	155566338	175338	0	None	-446	6	Human	6.3	pKi	=	6.3	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	405	4	4	8	1.4	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@H]4C[C@H]5CC[C@@H]4C5)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	CHEMBL4587144	175338	0	None	-446	6	Human	6.3	pKi	=	6.3	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	405	4	4	8	1.4	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@H]4C[C@H]5CC[C@@H]4C5)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	134134668	143721	0	None	-4	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	381	6	4	8	1.4	CCC(CC)Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12	10.1021/acs.jmedchem.6b01183
	CHEMBL3904817	143721	0	None	-4	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	381	6	4	8	1.4	CCC(CC)Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12	10.1021/acs.jmedchem.6b01183
	2477	734	54	None	-13	28	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
	36	734	54	None	-13	28	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
	437	734	54	None	-13	28	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
	CHEMBL49	734	54	None	-13	28	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
	DB00490	734	54	None	-13	28	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
	11666237	88683	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337496	88683	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365472	88683	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	11609026	88698	0	None	-3	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337500	88698	0	None	-3	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365705	88698	0	None	-3	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
	44409031	74607	0	None	-30	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	223	0	1	3	1.5	C[C@@H]1CNC[C@H]2Cc3ccc(Cl)nc3N12	10.1016/j.bmcl.2005.11.083
	CHEMBL203230	74607	0	None	-30	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	223	0	1	3	1.5	C[C@@H]1CNC[C@H]2Cc3ccc(Cl)nc3N12	10.1016/j.bmcl.2005.11.083
	122178702	120854	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	387	6	0	5	3.8	COc1cc2c(cc1OCCF)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
	CHEMBL3581247	120854	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	387	6	0	5	3.8	COc1cc2c(cc1OCCF)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
	168295984	191622	0	None	-12	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	431	6	0	5	5.0	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccccc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL5204813	191622	0	None	-12	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	431	6	0	5	5.0	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccccc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	134155462	150577	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	339	3	3	8	-0.2	CN(C)c1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12	10.1021/acs.jmedchem.6b01183
	CHEMBL3959210	150577	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	339	3	3	8	-0.2	CN(C)c1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12	10.1021/acs.jmedchem.6b01183
	10058473	20455	0	None	-4	4	Human	6.3	pKi	=	6.3	Binding	Compound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptorCompound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptor	ChEMBL	194	3	1	2	2.3	CN(C)CCc1c[nH]c2sccc12	10.1021/jm980692q
	CHEMBL13086	20455	0	None	-4	4	Human	6.3	pKi	=	6.3	Binding	Compound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptorCompound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptor	ChEMBL	194	3	1	2	2.3	CN(C)CCc1c[nH]c2sccc12	10.1021/jm980692q
	71681898	90658	0	None	1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	0	2	1.0	CN1CCN2C(=O)c3ccccc3C[C@@H]2C1	10.1016/j.bmcl.2013.04.061
	CHEMBL2397884	90658	0	None	1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	0	2	1.0	CN1CCN2C(=O)c3ccccc3C[C@@H]2C1	10.1016/j.bmcl.2013.04.061
	49865832	15987	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	310	3	1	3	3.3	CCCCNC(=O)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	CHEMBL1224035	15987	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	310	3	1	3	3.3	CCCCNC(=O)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	136118618	75897	0	None	4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3cc(Br)ccc23)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2058417	75897	0	None	4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3cc(Br)ccc23)N1C	10.1016/j.bmc.2013.09.011
	9859257	203413	0	None	-5	3	Human	7.3	pKi	=	7.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	218	2	1	3	1.3	C[C@H](N)CN1CCc2ccc3c(c21)CCO3	10.1016/j.bmcl.2003.05.001
	CHEMBL77880	203413	0	None	-5	3	Human	7.3	pKi	=	7.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	218	2	1	3	1.3	C[C@H](N)CN1CCc2ccc3c(c21)CCO3	10.1016/j.bmcl.2003.05.001
	2105	3005	34	None	-28	33	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	47811	3005	34	None	-28	33	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	48	3005	34	None	-28	33	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	CHEMBL531	3005	34	None	-28	33	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	DB01186	3005	34	None	-28	33	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	71028	83943	23	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	216	1	2	2	2.4	COc1ccc2[nH]c3c(c2c1)CCNC3C	10.1021/jm100600y
	CHEMBL221811	83943	23	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	216	1	2	2	2.4	COc1ccc2[nH]c3c(c2c1)CCNC3C	10.1021/jm100600y
	25122652	198978	0	None	-134	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	420	3	2	5	3.8	Cc1ccc(S(=O)(=O)c2n[nH]c3ccc(N4CCC(N)CC4)cc23)c2ccccc12	10.1021/jm901674f
	CHEMBL599663	198978	0	None	-134	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	420	3	2	5	3.8	Cc1ccc(S(=O)(=O)c2n[nH]c3ccc(N4CCC(N)CC4)cc23)c2ccccc12	10.1021/jm901674f
	11653679	180609	1	None	-75	11	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human cloned 5HT2B receptorBinding affinity to human cloned 5HT2B receptor	ChEMBL	374	6	0	3	4.7	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
	CHEMBL476108	180609	1	None	-75	11	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human cloned 5HT2B receptorBinding affinity to human cloned 5HT2B receptor	ChEMBL	374	6	0	3	4.7	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
	56707820	2866	34	None	-	1	Human	6.3	pKi	=	6.3	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000354a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000354a HTR2B	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	nan
	9155	2866	34	None	-	1	Human	6.3	pKi	=	6.3	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000354a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000354a HTR2B	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	nan
	CHEMBL4548689	2866	34	None	-	1	Human	6.3	pKi	=	6.3	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000354a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000354a HTR2B	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	nan
	5009938	15235	1	None	1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	306	4	0	3	3.8	c1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
	CHEMBL1214829	15235	1	None	1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	306	4	0	3	3.8	c1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
	11393128	182279	0	None	-2	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	323	2	1	3	3.8	CC(C)n1nc2c(c1-c1ccc(C(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4791646	182279	0	None	-2	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	323	2	1	3	3.8	CC(C)n1nc2c(c1-c1ccc(C(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	10527432	36057	0	None	1	3	Human	8.3	pKi	=	8.3	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	447	3	1	3	6.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3)c1Cl)CC2	10.1021/jm990388c
	CHEMBL14458	36057	0	None	1	3	Human	8.3	pKi	=	8.3	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	447	3	1	3	6.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3)c1Cl)CC2	10.1021/jm990388c
	10550405	37824	0	None	-5	3	Human	8.3	pKi	=	8.3	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	427	3	1	3	5.7	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(C)c(-c3cccnc3)c1)CC2	10.1021/jm990388c
	CHEMBL14606	37824	0	None	-5	3	Human	8.3	pKi	=	8.3	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	427	3	1	3	5.7	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(C)c(-c3cccnc3)c1)CC2	10.1021/jm990388c
	75306277	108767	0	None	-2	23	Human	8.3	pKi	=	8.3	Binding	Binding affinity to serotonin 5-HT2B receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	308	0	0	3	4.2	CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3	10.1039/C2MD00311B
	CHEMBL3217984	108767	0	None	-2	23	Human	8.3	pKi	=	8.3	Binding	Binding affinity to serotonin 5-HT2B receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	308	0	0	3	4.2	CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3	10.1039/C2MD00311B
	166	3307	12	None	1	3	Human	8.3	pKi	=	8.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
	3045227	3307	12	None	1	3	Human	8.3	pKi	=	8.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
	CHEMBL76781	3307	12	None	1	3	Human	8.3	pKi	=	8.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
	166	3307	12	None	1	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2005.10.029
	3045227	3307	12	None	1	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2005.10.029
	CHEMBL76781	3307	12	None	1	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2005.10.029
	11536843	114625	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343673	114625	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	11500509	120070	0	None	-3	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343670	120070	0	None	-3	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3545812	120070	0	None	-3	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	31101	720	39	None	-26	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	35	720	39	None	-26	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	403	720	39	None	-26	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	CHEMBL493	720	39	None	-26	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	DB01200	720	39	None	-26	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	10331436	321	7	None	-2	6	Human	8.3	pKi	=	8.3	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	230	2	2	2	2.4	C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N	10.1021/jm030205t
	160	321	7	None	-2	6	Human	8.3	pKi	=	8.3	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	230	2	2	2	2.4	C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N	10.1021/jm030205t
	CHEMBL133455	321	7	None	-2	6	Human	8.3	pKi	=	8.3	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	230	2	2	2	2.4	C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N	10.1021/jm030205t
	242	467	117	None	-1	51	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113931
	34	467	117	None	-1	51	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113931
	60795	467	117	None	-1	51	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113931
	CHEMBL1112	467	117	None	-1	51	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113931
	DB01238	467	117	None	-1	51	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113931
	44364163	39550	1	None	-3	4	Human	8.2	pKi	=	8.2	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	190	1	2	1	2.1	NC1CC1c1c[nH]c2ccc(F)cc12	10.1021/jm980318q
	CHEMBL147656	39550	1	None	-3	4	Human	8.2	pKi	=	8.2	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	190	1	2	1	2.1	NC1CC1c1c[nH]c2ccc(F)cc12	10.1021/jm980318q
	118464420	137717	0	None	26	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL3770342	137717	0	None	26	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
	127035063	135963	0	None	21	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	477	13	0	6	5.2	COc1ccccc1CCCN(CCc1ccc(OC)c(OC)c1)CCc1ccc2c(c1)OCO2	10.1039/C4MD00418C
	CHEMBL3736149	135963	0	None	21	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	477	13	0	6	5.2	COc1ccccc1CCCN(CCc1ccc(OC)c(OC)c1)CCc1ccc2c(c1)OCO2	10.1039/C4MD00418C
	44404886	71881	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	260	6	1	3	3.3	CCCCn1cc(CCN(C)C)c2c(O)cccc21	10.1016/j.bmcl.2005.06.104
	CHEMBL198124	71881	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	260	6	1	3	3.3	CCCCn1cc(CCN(C)C)c2c(O)cccc21	10.1016/j.bmcl.2005.06.104
	CHEMBL5077293	212720	0	None	-17	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCNC2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	136118648	75968	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.0	C/N=C1\NC(=O)/C(=C/c2c[nH]c3cccc(Br)c23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2058703	75968	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.0	C/N=C1\NC(=O)/C(=C/c2c[nH]c3cccc(Br)c23)N1	10.1016/j.bmc.2013.09.011
	118729266	120188	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(Cl)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402676	120188	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(Cl)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547137	120188	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(Cl)c2)C1	10.1016/j.bmc.2015.01.060
	10837002	35139	0	None	-79	3	Human	7.3	pKi	=	7.3	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	444	4	1	5	5.2	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1021/jm990388c
	CHEMBL14374	35139	0	None	-79	3	Human	7.3	pKi	=	7.3	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	444	4	1	5	5.2	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1021/jm990388c
	18475647	196035	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	334	5	2	3	4.7	CCN(CC)c1ccc(NC(=O)Nc2ccnc3ccccc23)cc1	10.1016/s0960-894x(01)00343-2
	CHEMBL57135	196035	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	334	5	2	3	4.7	CCN(CC)c1ccc(NC(=O)Nc2ccnc3ccccc23)cc1	10.1016/s0960-894x(01)00343-2
	10837002	35139	0	None	-79	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	444	4	1	5	5.2	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL14374	35139	0	None	-79	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	444	4	1	5	5.2	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	44298175	100473	0	None	-39	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.5	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cccnc3Cl)nc1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL294030	100473	0	None	-39	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.5	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cccnc3Cl)nc1)CC2	10.1016/s0960-894x(00)00364-4
	11742218	194120	0	None	-25	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	408	4	1	4	5.4	CCc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(C)c(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL55792	194120	0	None	-25	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	408	4	1	4	5.4	CCc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(C)c(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
	18931202	205076	0	None	-12	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	393	7	2	5	2.4	COc1ccc(Cl)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
	CHEMBL90346	205076	0	None	-12	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	393	7	2	5	2.4	COc1ccc(Cl)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
	73350823	102057	0	None	-33	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptor by competitive binding assayBinding affinity to human 5HT2B receptor by competitive binding assay	ChEMBL	509	8	1	5	3.7	O=C(Cc1ccc(OC2CCNCC2)cc1OCCF)N1CCC(N2C(=O)CCc3ccccc32)CC1	10.1016/j.bmcl.2013.07.045
	CHEMBL2424668	102057	0	None	-33	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptor by competitive binding assayBinding affinity to human 5HT2B receptor by competitive binding assay	ChEMBL	509	8	1	5	3.7	O=C(Cc1ccc(OC2CCNCC2)cc1OCCF)N1CCC(N2C(=O)CCc3ccccc32)CC1	10.1016/j.bmcl.2013.07.045
	CHEMBL3040578	102057	0	None	-33	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptor by competitive binding assayBinding affinity to human 5HT2B receptor by competitive binding assay	ChEMBL	509	8	1	5	3.7	O=C(Cc1ccc(OC2CCNCC2)cc1OCCF)N1CCC(N2C(=O)CCc3ccccc32)CC1	10.1016/j.bmcl.2013.07.045
	10257042	202658	0	None	-12	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity for 5-hydroxytryptamine 2B receptor was determinedBinding affinity for 5-hydroxytryptamine 2B receptor was determined	ChEMBL	551	6	3	3	7.3	O=C(/C=C/c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@@H](CN2[C@H]3CC[C@@H]2C[C@@H](c2c[nH]c4ccc(O)cc24)C3)CC1	10.1016/s0960-894x(01)00397-3
	CHEMBL71707	202658	0	None	-12	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity for 5-hydroxytryptamine 2B receptor was determinedBinding affinity for 5-hydroxytryptamine 2B receptor was determined	ChEMBL	551	6	3	3	7.3	O=C(/C=C/c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@@H](CN2[C@H]3CC[C@@H]2C[C@@H](c2c[nH]c4ccc(O)cc24)C3)CC1	10.1016/s0960-894x(01)00397-3
	9866423	71960	0	None	-316	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	413	7	0	4	4.1	COc1ccc(N2CCN(c3cccc(F)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
	CHEMBL198330	71960	0	None	-316	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	413	7	0	4	4.1	COc1ccc(N2CCN(c3cccc(F)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
	24887527	79616	0	None	-100	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	440	7	0	4	4.9	COc1ccc(N2CC=C(c3cccc(Cl)c3)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.05.034
	CHEMBL212886	79616	0	None	-100	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	440	7	0	4	4.9	COc1ccc(N2CC=C(c3cccc(Cl)c3)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.05.034
	24887290	79839	0	None	-630	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	410	7	0	4	4.1	COc1ccc(N2CC=C(c3cccc(F)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	CHEMBL213839	79839	0	None	-630	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	410	7	0	4	4.1	COc1ccc(N2CC=C(c3cccc(F)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	44414051	165674	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	440	7	0	4	5.0	COc1ccc(C2=C(C)CN(c3ccc(Cl)cc3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	CHEMBL426684	165674	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	440	7	0	4	5.0	COc1ccc(C2=C(C)CN(c3ccc(Cl)cc3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	10454231	168395	0	None	-79	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	410	7	0	4	4.1	COc1ccc(C2=CCN(c3cccc(F)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	CHEMBL438963	168395	0	None	-79	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	410	7	0	4	4.1	COc1ccc(C2=CCN(c3cccc(F)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	11292933	56100	39	None	-2511	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	415	5	1	4	3.4	Cc1ccc2c(N3CCN(CCc4cccc(N5CCNC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
	CHEMBL1631540	56100	39	None	-2511	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	415	5	1	4	3.4	Cc1ccc2c(N3CCN(CCc4cccc(N5CCNC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
	44298100	194391	0	None	-158	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.5	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3c2ccc(Cl)c3Cl)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL56050	194391	0	None	-158	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.5	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3c2ccc(Cl)c3Cl)cn1	10.1016/s0960-894x(00)00364-4
	153287551	169385	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	307	1	0	2	3.8	CC(=O)N1CC[C@H]2c3cccc(-c4ccccc4)c3OC[C@]21C	10.1021/acsmedchemlett.9b00225
	CHEMBL4441621	169385	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	307	1	0	2	3.8	CC(=O)N1CC[C@H]2c3cccc(-c4ccccc4)c3OC[C@]21C	10.1021/acsmedchemlett.9b00225
	153287553	170538	0	None	-79	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	264	1	1	2	3.7	C[C@@]12CN(c3ccccc3)c3ccccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	CHEMBL4457754	170538	0	None	-79	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	264	1	1	2	3.7	C[C@@]12CN(c3ccccc3)c3ccccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	17989823	151544	0	None	-316	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.0	COc1ccc(N2Cc3cccc(C(F)(F)F)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	CHEMBL396748	151544	0	None	-316	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.0	COc1ccc(N2Cc3cccc(C(F)(F)F)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	10813396	98263	0	None	-6	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	449	3	1	3	5.6	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3cc(F)cc(F)c3)c1)CC2	10.1021/jm990388c
	CHEMBL277732	98263	0	None	-6	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	449	3	1	3	5.6	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3cc(F)cc(F)c3)c1)CC2	10.1021/jm990388c
	18357723	193848	0	None	-31	3	Human	6.3	pKi	=	6.3	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	424	4	1	4	4.4	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2cc(Br)ccc21	10.1016/s0960-894x(00)00365-6
	CHEMBL55388	193848	0	None	-31	3	Human	6.3	pKi	=	6.3	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	424	4	1	4	4.4	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2cc(Br)ccc21	10.1016/s0960-894x(00)00365-6
	44298129	194283	0	None	-125	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	364	3	1	4	4.3	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(F)ccc32)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL55958	194283	0	None	-125	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	364	3	1	4	4.3	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(F)ccc32)cn1	10.1016/s0960-894x(00)00364-4
	2028	2931	77	None	-40	11	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	359	2931	77	None	-40	11	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	4634	2931	77	None	-40	11	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	CHEMBL1231	2931	77	None	-40	11	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	DB01062	2931	77	None	-40	11	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	136020617	57025	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@@H]1CO	10.1021/np100588c
	CHEMBL1651095	57025	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@@H]1CO	10.1021/np100588c
	132060770	162089	0	None	-8	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	451	7	0	6	3.5	CCOC(=O)CCN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1	10.1016/j.ejmech.2018.02.024
	CHEMBL4169689	162089	0	None	-8	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	451	7	0	6	3.5	CCOC(=O)CCN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1	10.1016/j.ejmech.2018.02.024
	135367820	164269	0	None	-9	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218672	164269	0	None	-9	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	135846981	92620	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	254	1	2	2	1.6	C/N=C1/N/C(=C/c2c[nH]c3ccccc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2442265	92620	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	254	1	2	2	1.6	C/N=C1/N/C(=C/c2c[nH]c3ccccc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL5072247	212504	5	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL		None	None	None		CC[C@H]1CN2CCc3c([nH]c4cccc(O)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	145980271	165939	0	None	1	16	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	538	8	1	3	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	CHEMBL4278465	165939	0	None	1	16	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	538	8	1	3	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	71452172	83105	0	None	-1	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by microbeta scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by microbeta scintillation counting analysis	ChEMBL	274	6	1	5	2.4	c1ccc(OCc2cc(OC[C@@H]3CCCN3)no2)cc1	10.1021/ml3002715
	CHEMBL2203551	83105	0	None	-1	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by microbeta scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by microbeta scintillation counting analysis	ChEMBL	274	6	1	5	2.4	c1ccc(OCc2cc(OC[C@@H]3CCCN3)no2)cc1	10.1021/ml3002715
	46230100	197639	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	231	0	2	3	0.9	Cc1ccc2c(c1)N1CCNCCC1NC2=O	10.1016/j.bmcl.2009.12.014
	CHEMBL590531	197639	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	231	0	2	3	0.9	Cc1ccc2c(c1)N1CCNCCC1NC2=O	10.1016/j.bmcl.2009.12.014
	127049981	140069	0	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	573	12	0	5	5.8	COc1ccc(CCN(CCCc2ccc(I)cc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3813789	140069	0	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	573	12	0	5	5.8	COc1ccc(CCN(CCCc2ccc(I)cc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	135464118	92628	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2442272	92628	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1	10.1016/j.bmc.2013.09.011
	155556596	173851	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Inhibition of human 5HT2B by radio-ligand binding displacement assayInhibition of human 5HT2B by radio-ligand binding displacement assay	ChEMBL	428	5	4	7	3.1	OC[C@@]12C[C@@H]1[C@@H](n1cc(-c3ccccc3)c3c(Nc4ccccc4)ncnc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b00689
	CHEMBL4552895	173851	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Inhibition of human 5HT2B by radio-ligand binding displacement assayInhibition of human 5HT2B by radio-ligand binding displacement assay	ChEMBL	428	5	4	7	3.1	OC[C@@]12C[C@@H]1[C@@H](n1cc(-c3ccccc3)c3c(Nc4ccccc4)ncnc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b00689
	161	743	3	None	2	6	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	nan
	4284720	743	3	None	2	6	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	nan
	CHEMBL1255834	743	3	None	2	6	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	nan
	58911644	90669	0	None	3	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	227	0	1	3	0.5	N#Cc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397895	90669	0	None	3	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	227	0	1	3	0.5	N#Cc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	136020617	57025	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@@H]1CO	10.1021/acs.jnatprod.7b00317
	CHEMBL1651095	57025	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@@H]1CO	10.1021/acs.jnatprod.7b00317
	44407460	139820	0	None	-6	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	315	5	1	3	4.4	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccccc1	10.1016/j.bmcl.2005.10.029
	CHEMBL380763	139820	0	None	-6	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	315	5	1	3	4.4	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccccc1	10.1016/j.bmcl.2005.10.029
	90181061	160324	0	None	1	2	Mouse	5.3	pKi	=	5.3	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	381	5	0	5	2.4	Cc1ncccc1OC[C@H]1CN(CC(=O)N2c3ccccc3CC2C)CCO1	nan
	CHEMBL4115017	160324	0	None	1	2	Mouse	5.3	pKi	=	5.3	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	381	5	0	5	2.4	Cc1ncccc1OC[C@H]1CN(CC(=O)N2c3ccccc3CC2C)CCO1	nan
	145	140	48	None	-87	29	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm050663x
	1832	140	48	None	-87	29	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm050663x
	CHEMBL7257	140	48	None	-87	29	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm050663x
	DB14010	140	48	None	-87	29	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm050663x
	2726	906	64	None	-19	72	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm100600y
	621	906	64	None	-19	72	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm100600y
	83	906	64	None	-19	72	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm100600y
	CHEMBL71	906	64	None	-19	72	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm100600y
	DB00477	906	64	None	-19	72	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm100600y
	72735042	105829	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	293	2	3	2	1.6	NC(N)=NC(=O)/C=C/c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3092763	105829	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	293	2	3	2	1.6	NC(N)=NC(=O)/C=C/c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3139089	105829	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	293	2	3	2	1.6	NC(N)=NC(=O)/C=C/c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	127036953	136990	0	None	-5	22	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	318	7	1	1	4.1	C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12	10.1016/j.bmcl.2015.12.053
	CHEMBL3754166	136990	0	None	-5	22	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	318	7	1	1	4.1	C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12	10.1016/j.bmcl.2015.12.053
	118709751	113042	0	None	-407	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccccc1F	10.1016/j.bmcl.2014.07.018
	CHEMBL3321792	113042	0	None	-407	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccccc1F	10.1016/j.bmcl.2014.07.018
	136118653	92622	0	None	2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3ccc(Br)cc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2442267	92622	0	None	2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3ccc(Br)cc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
	54764240	68526	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	242	1	1	2	2.7	CC/C=C1\C[C@H]2CNc3ccccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
	CHEMBL1922539	68526	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	242	1	1	2	2.7	CC/C=C1\C[C@H]2CNc3ccccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
	CHEMBL4592872	212267	0	None	-4	3	Human	5.3	pKi	=	5.3	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000340a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000340a HTR2B	ChEMBL		None	None	None		O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@H]1c1ccc(F)cc1	nan
	58405078	110207	0	None	-6	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	310	5	1	5	3.0	Cc1nc(COc2ccc(Cl)cc2OC2CNC2)cs1	10.1021/ml500082j
	CHEMBL3260335	110207	0	None	-6	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	310	5	1	5	3.0	Cc1nc(COc2ccc(Cl)cc2OC2CNC2)cs1	10.1021/ml500082j
	398712	77516	5	None	-52	5	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5HT2B receptor by radioligand binding assayBinding affinity to 5HT2B receptor by radioligand binding assay	ChEMBL	417	9	1	5	2.9	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm0508641
	CHEMBL209324	77516	5	None	-52	5	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5HT2B receptor by radioligand binding assayBinding affinity to 5HT2B receptor by radioligand binding assay	ChEMBL	417	9	1	5	2.9	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm0508641
	9859144	67024	1	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	208	0	1	2	1.7	Clc1ccc2c(c1)N1CCNCC1C2	10.1016/j.bmcl.2005.05.074
	CHEMBL188605	67024	1	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	208	0	1	2	1.7	Clc1ccc2c(c1)N1CCNCC1C2	10.1016/j.bmcl.2005.05.074
	122178701	120853	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	425	9	0	5	5.4	CCCCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL3581246	120853	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	425	9	0	5	5.4	CCCCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	122178708	120860	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	423	5	0	5	5.2	COc1cc2c(cc1OC1CCCCC1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
	CHEMBL3581253	120860	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	423	5	0	5	5.2	COc1cc2c(cc1OC1CCCCC1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
	2884131	166355	7	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	275	1	3	5	2.2	NC1=NC2(CCCCC2)NC(Nc2cccc(F)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL4286420	166355	7	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	275	1	3	5	2.2	NC1=NC2(CCCCC2)NC(Nc2cccc(F)c2)=N1	10.1021/acsmedchemlett.8b00300
	71655748	87397	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	359	5	1	4	4.8	CC(C)CCOc1ccc2c(c1)[C@H]1OCCC[C@H]1[C@@H](C1CCOCC1)N2	10.1021/jm400181k
	CHEMBL2338343	87397	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	359	5	1	4	4.8	CC(C)CCOc1ccc2c(c1)[C@H]1OCCC[C@H]1[C@@H](C1CCOCC1)N2	10.1021/jm400181k
	142601335	185839	0	None	-44	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876193	185839	0	None	-44	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	134157367	153364	0	None	4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	517	10	5	9	1.0	CC(=O)NCCCNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3983143	153364	0	None	4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	517	10	5	9	1.0	CC(=O)NCCCNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	11644842	88668	0	None	-6	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	244	1	2	2	1.9	Cc1cc(C(C)C)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337105	88668	0	None	-6	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	244	1	2	2	1.9	Cc1cc(C(C)C)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365394	88668	0	None	-6	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	244	1	2	2	1.9	Cc1cc(C(C)C)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	4098	32289	24	None	-14	11	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
	CHEMBL1255739	32289	24	None	-14	11	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
	CHEMBL1411979	32289	24	None	-14	11	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
	CHEMBL4557026	212254	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000700a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000700a HTR2B	ChEMBL		None	None	None		C[C@H](NC(=O)Nc1cc2[nH]ncc2c(CO)n1)c1ccccn1	nan
	54764241	68525	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	258	1	1	3	2.3	C/C=C1\C[C@H]2CNc3c(OC)cccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
	CHEMBL1922538	68525	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	258	1	1	3	2.3	C/C=C1\C[C@H]2CNc3c(OC)cccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
	18735313	203226	1	None	-4	3	Human	7.3	pKi	=	7.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	210	2	1	2	2.1	C[C@H](N)CN1CCc2ccc(Cl)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL76307	203226	1	None	-4	3	Human	7.3	pKi	=	7.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	210	2	1	2	2.1	C[C@H](N)CN1CCc2ccc(Cl)cc21	10.1016/j.bmcl.2003.05.001
	24826868	90651	1	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	236	0	1	2	1.3	O=C1c2cc(Cl)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397877	90651	1	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	236	0	1	2	1.3	O=C1c2cc(Cl)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	127049979	140119	0	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	481	12	0	5	5.8	COc1ccc(CCN(CCCc2ccc(Cl)cc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3814708	140119	0	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	481	12	0	5	5.8	COc1ccc(CCN(CCCc2ccc(Cl)cc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	5282379	193314	64	None	1	3	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C\C(=O)O)C(C)(C)CCC1	nan
	CHEMBL547	193314	64	None	1	3	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C\C(=O)O)C(C)(C)CCC1	nan
	118729242	120173	0	None	-1	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(C(F)(F)F)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402661	120173	0	None	-1	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(C(F)(F)F)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547028	120173	0	None	-1	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(C(F)(F)F)cc2)C1	10.1016/j.bmc.2015.01.060
	181743	177997	3	None	-275	22	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2015.07.012
	CHEMBL467094	177997	3	None	-275	22	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2015.07.012
	181743	177997	3	None	-275	22	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2009.11.053
	CHEMBL467094	177997	3	None	-275	22	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2009.11.053
	16115511	84413	0	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	250	1	1	2	2.0	CCc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL223466	84413	0	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	250	1	1	2	2.0	CCc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	122178709	120861	0	None	-2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	381	6	0	5	4.0	C=CCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL3581254	120861	0	None	-2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	381	6	0	5	4.0	C=CCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	4407909	192264	1	None	4	10	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5182943	192264	1	None	4	10	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221893	192264	1	None	4	10	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	118055233	176694	0	None	-38	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	214	0	1	2	2.0	c1cc2c3c(c1)C1(CCC1)CN3CCNC2	10.1016/j.bmcl.2019.126929
	CHEMBL4636196	176694	0	None	-38	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	214	0	1	2	2.0	c1cc2c3c(c1)C1(CCC1)CN3CCNC2	10.1016/j.bmcl.2019.126929
	11448649	83020	0	None	-27	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	272	1	1	3	1.7	O=C1c2c(OC(F)(F)F)cccc2C2CNCCN12	10.1021/jm0612968
	CHEMBL219734	83020	0	None	-27	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	272	1	1	3	1.7	O=C1c2c(OC(F)(F)F)cccc2C2CNCCN12	10.1021/jm0612968
	29101	71880	1	None	-10	2	Human	5.3	pKi	=	5.3	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	298	5	2	4	1.8	CN(C)CCc1cn(C)c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL198123	71880	1	None	-10	2	Human	5.3	pKi	=	5.3	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	298	5	2	4	1.8	CN(C)CCc1cn(C)c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	71061709	148995	0	None	-3	12	Mouse	6.3	pKi	=	6.3	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	372	6	0	4	3.5	Clc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
	CHEMBL3946540	148995	0	None	-3	12	Mouse	6.3	pKi	=	6.3	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	372	6	0	4	3.5	Clc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
	11222829	90680	0	None	-3	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	270	0	1	2	1.7	O=C1c2cccc(C(F)(F)F)c2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397906	90680	0	None	-3	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	270	0	1	2	1.7	O=C1c2cccc(C(F)(F)F)c2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	162669941	182073	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	409	6	4	8	1.8	CC(C)C(Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C(C)C	10.1016/j.bmcl.2020.127599
	CHEMBL4788883	182073	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	409	6	4	8	1.8	CC(C)C(Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C(C)C	10.1016/j.bmcl.2020.127599
	44404895	170242	0	None	-12	3	Human	5.3	pKi	=	5.3	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	292	3	2	2	3.9	Oc1cccc2[nH]cc(CCN3CCCc4ccccc43)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL445331	170242	0	None	-12	3	Human	5.3	pKi	=	5.3	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	292	3	2	2	3.9	Oc1cccc2[nH]cc(CCN3CCCc4ccccc43)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL4798829	212289	4	None	6	2	Human	6.3	pKi	=	6.3	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000752a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000752a HTR2B	ChEMBL		None	None	None		c1ccc2oc(-c3csc(C4CCN(Cc5nc6ncccc6[nH]5)CC4)n3)cc2c1	nan
	44582705	186413	0	None	-3	13	Human	6.3	pKi	=	6.3	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	399	9	0	4	4.5	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL490632	186413	0	None	-3	13	Human	6.3	pKi	=	6.3	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	399	9	0	4	4.5	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
	3158	55974	21	None	-389	20	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
	CHEMBL1628227	55974	21	None	-389	20	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
	122178699	120852	0	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	397	7	0	5	4.6	CCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL3581245	120852	0	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	397	7	0	5	4.6	CCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	216239	23591	114	None	2	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counter	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1021/jm300338m
	CHEMBL1200485	23591	114	None	2	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counter	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1021/jm300338m
	CHEMBL1336	23591	114	None	2	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counter	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1021/jm300338m
	73213195	103980	0	None	-1	12	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
	CHEMBL3104092	103980	0	None	-1	12	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
	11808247	17891	0	None	-6	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL126667	17891	0	None	-6	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819366	17891	0	None	-6	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	11808247	17891	0	None	-6	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL126667	17891	0	None	-6	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819366	17891	0	None	-6	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	44456400	12725	0	None	-2	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	CHEMBL1188501	12725	0	None	-2	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	CHEMBL2436555	12725	0	None	-2	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	CHEMBL536539	12725	0	None	-2	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	44456400	12725	0	None	-2	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	CHEMBL1188501	12725	0	None	-2	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	CHEMBL2436555	12725	0	None	-2	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	CHEMBL536539	12725	0	None	-2	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	49865830	15984	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	296	1	1	3	3.0	CC(C)NC(=O)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	CHEMBL1224032	15984	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	296	1	1	3	3.0	CC(C)NC(=O)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	41305446	166699	1	None	1	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting methodDisplacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting method	ChEMBL	398	5	1	2	4.5	O=C(NCc1ccccc1)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1039/C8MD00204E
	CHEMBL4292719	166699	1	None	1	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting methodDisplacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting method	ChEMBL	398	5	1	2	4.5	O=C(NCc1ccccc1)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1039/C8MD00204E
	46914772	15267	0	None	56	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	368	7	0	4	4.1	FCCOc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
	CHEMBL1215036	15267	0	None	56	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	368	7	0	4	4.1	FCCOc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
	73213195	103980	0	None	-1	12	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
	CHEMBL3104092	103980	0	None	-1	12	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
	122178700	120791	0	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	411	8	0	5	5.0	CCCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL3580670	120791	0	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	411	8	0	5	5.0	CCCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	71681899	90656	0	None	-3	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	202	0	1	2	0.7	O=C1c2ccccc2C[C@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397882	90656	0	None	-3	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	202	0	1	2	0.7	O=C1c2ccccc2C[C@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	2291	3135	52	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
	2561	3135	52	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
	4932	3135	52	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
	CHEMBL631	3135	52	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
	DB01182	3135	52	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
	44364514	121185	9	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	172	1	2	1	2.0	NC1CC1c1c[nH]c2ccccc12	10.1021/jm980318q
	CHEMBL358810	121185	9	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	172	1	2	1	2.0	NC1CC1c1c[nH]c2ccccc12	10.1021/jm980318q
	10103618	121012	4	None	-1	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	172	1	2	1	2.0	N[C@@H]1C[C@H]1c1c[nH]c2ccccc12	10.1021/jm980318q
	CHEMBL358522	121012	4	None	-1	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	172	1	2	1	2.0	N[C@@H]1C[C@H]1c1c[nH]c2ccccc12	10.1021/jm980318q
	50878551	90314	60	None	-1	18	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2015.12.053
	CHEMBL2391541	90314	60	None	-1	18	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2015.12.053
	11492300	88682	1	None	-5	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	188	0	2	2	0.5	O=C1N[C@H]2CNC[C@@H]2c2ccccc21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337495	88682	1	None	-5	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	188	0	2	2	0.5	O=C1N[C@H]2CNC[C@@H]2c2ccccc21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365471	88682	1	None	-5	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	188	0	2	2	0.5	O=C1N[C@H]2CNC[C@@H]2c2ccccc21	10.1016/j.bmcl.2012.10.091
	68691189	90677	0	None	1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	227	0	1	3	0.5	N#Cc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397903	90677	0	None	1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	227	0	1	3	0.5	N#Cc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	25117677	198568	0	None	-23	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	420	4	1	5	3.7	CN(C)[C@H]1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
	CHEMBL597009	198568	0	None	-23	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	420	4	1	5	3.7	CN(C)[C@H]1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
	176	394	63	None	-1	31	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2157	394	63	None	-1	31	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2566	394	63	None	-1	31	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	CHEMBL633	394	63	None	-1	31	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	DB01118	394	63	None	-1	31	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	127051844	140316	0	None	-48	9	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	322	6	1	3	2.8	NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819427	140316	0	None	-48	9	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	322	6	1	3	2.8	NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	127051844	140316	0	None	-48	9	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	322	6	1	3	2.8	NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819427	140316	0	None	-48	9	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	322	6	1	3	2.8	NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	136118620	75899	0	None	-1	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.6	CN1C(=N)N(C)/C(=C/c2c[nH]c3cccc(Br)c23)C1=O	10.1016/j.bmc.2013.09.011
	CHEMBL2058419	75899	0	None	-1	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.6	CN1C(=N)N(C)/C(=C/c2c[nH]c3cccc(Br)c23)C1=O	10.1016/j.bmc.2013.09.011
	44397846	67303	0	None	-22	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	202	0	1	2	1.7	Cc1cccc2c1N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
	CHEMBL190584	67303	0	None	-22	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	202	0	1	2	1.7	Cc1cccc2c1N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
	127034729	135842	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	463	12	0	6	5.1	COc1cccc(CCCN(CCc2ccc(OC)c(OC)c2)Cc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
	CHEMBL3734894	135842	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	463	12	0	6	5.1	COc1cccc(CCCN(CCc2ccc(OC)c(OC)c2)Cc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
	127036910	135942	0	None	18	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	419	10	0	5	4.7	COc1ccc(CCN(CCc2ccc3c(c2)OCO3)Cc2ccccc2)cc1OC	10.1039/C4MD00418C
	CHEMBL3735862	135942	0	None	18	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	419	10	0	5	4.7	COc1ccc(CCN(CCc2ccc3c(c2)OCO3)Cc2ccccc2)cc1OC	10.1039/C4MD00418C
	136118615	92633	0	None	2	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3c(Br)cccc23)C1=O	10.1016/j.bmc.2013.09.011
	CHEMBL2442277	92633	0	None	2	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3c(Br)cccc23)C1=O	10.1016/j.bmc.2013.09.011
	657255	197406	29	None	-9	15	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	nan
	CHEMBL588119	197406	29	None	-9	15	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	nan
	45486824	195701	0	None	-14	3	Human	8.2	pKi	=	8.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	421	4	3	4	3.3	O=C1Cc2c(ccc3c2OC[C@H](CNCC2CCc4[nH]c5ccc(F)cc5c4C2)O3)N1	10.1016/j.bmcl.2009.08.050
	CHEMBL569251	195701	0	None	-14	3	Human	8.2	pKi	=	8.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	421	4	3	4	3.3	O=C1Cc2c(ccc3c2OC[C@H](CNCC2CCc4[nH]c5ccc(F)cc5c4C2)O3)N1	10.1016/j.bmcl.2009.08.050
	135427931	72773	2	None	-1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	317	2	2	4	1.7	C[C@H](N)Cn1ncc2ccc(O)c(I)c21	10.1021/jm050663x
	CHEMBL201132	72773	2	None	-1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	317	2	2	4	1.7	C[C@H](N)Cn1ncc2ccc(O)c(I)c21	10.1021/jm050663x
	58911579	90665	0	None	12	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	242	1	1	2	1.5	O=C1c2c(cccc2C2CC2)C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397891	90665	0	None	12	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	242	1	1	2	1.5	O=C1c2c(cccc2C2CC2)C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	277	1274	55	None	-5	45	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	2913	1274	55	None	-5	45	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	765	1274	55	None	-5	45	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	CHEMBL516	1274	55	None	-5	45	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	DB00434	1274	55	None	-5	45	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	118464420	137717	0	None	26	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770342	137717	0	None	26	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acs.jmedchem.5b01631
	118464421	166739	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	291	1	3	5	2.7	NC1=NC2(CCCCC2)NC(Nc2cccc(Cl)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL4293638	166739	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	291	1	3	5	2.7	NC1=NC2(CCCCC2)NC(Nc2cccc(Cl)c2)=N1	10.1021/acsmedchemlett.8b00300
	118706294	120024	0	None	7	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	311	3	3	3	1.3	COCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	CHEMBL3310118	120024	0	None	7	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	311	3	3	3	1.3	COCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	CHEMBL3545470	120024	0	None	7	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	311	3	3	3	1.3	COCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	44324142	205228	0	None	-25	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	427	7	2	5	3.0	COc1cc(Cl)c(Cl)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
	CHEMBL91221	205228	0	None	-25	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	427	7	2	5	3.0	COc1cc(Cl)c(Cl)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
	10670191	40656	0	None	-15	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	428	3	1	4	5.1	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3cnccc3C)c1)CC2	10.1021/jm990388c
	CHEMBL14864	40656	0	None	-15	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	428	3	1	4	5.1	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3cnccc3C)c1)CC2	10.1021/jm990388c
	135398745	2869	108	None	-5	65	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm070516u
	47	2869	108	None	-5	65	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm070516u
	CHEMBL715	2869	108	None	-5	65	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm070516u
	DB00334	2869	108	None	-5	65	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm070516u
	44298080	194296	0	None	-1	3	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	431	4	1	5	4.3	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3cncn3C)nc1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL55969	194296	0	None	-1	3	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	431	4	1	5	4.3	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3cncn3C)nc1)CC2	10.1016/s0960-894x(00)00365-6
	191	399	92	None	-5	28	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	201	399	92	None	-5	28	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	2170	399	92	None	-5	28	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	CHEMBL1113	399	92	None	-5	28	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	DB00543	399	92	None	-5	28	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	118706292	120023	0	None	6	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	297	2	4	3	0.7	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(CO)c1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310117	120023	0	None	6	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	297	2	4	3	0.7	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(CO)c1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545469	120023	0	None	6	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	297	2	4	3	0.7	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(CO)c1-2	10.1016/j.bmc.2014.05.027
	127035065	135977	0	None	30	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	477	13	0	6	5.2	COc1ccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1	10.1039/C4MD00418C
	CHEMBL3736207	135977	0	None	30	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	477	13	0	6	5.2	COc1ccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1	10.1039/C4MD00418C
	73453	29403	22	None	-9	17	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
	CHEMBL1385840	29403	22	None	-9	17	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
	118729258	120184	0	None	-6	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(C(F)(F)F)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402671	120184	0	None	-6	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(C(F)(F)F)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547133	120184	0	None	-6	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(C(F)(F)F)c2)C1	10.1016/j.bmc.2015.01.060
	127036186	136889	0	None	-1	19	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	254	7	1	1	3.7	C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12	10.1016/j.bmcl.2015.12.053
	CHEMBL3753318	136889	0	None	-1	19	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	254	7	1	1	3.7	C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12	10.1016/j.bmcl.2015.12.053
	71062829	159587	0	None	1	3	Mouse	6.2	pKi	=	6.2	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	339	6	0	5	2.2	c1ccc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)nc1	nan
	CHEMBL4108986	159587	0	None	1	3	Mouse	6.2	pKi	=	6.2	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	339	6	0	5	2.2	c1ccc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)nc1	nan
	10659364	120202	0	None	-50	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	265	2	0	1	4.0	Cc1ccccc1[C@@H]1C[C@@H](N(C)C)Cc2ccccc21	10.1016/j.bmc.2015.01.060
	CHEMBL3402685	120202	0	None	-50	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	265	2	0	1	4.0	Cc1ccccc1[C@@H]1C[C@@H](N(C)C)Cc2ccccc21	10.1016/j.bmc.2015.01.060
	CHEMBL3547178	120202	0	None	-50	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	265	2	0	1	4.0	Cc1ccccc1[C@@H]1C[C@@H](N(C)C)Cc2ccccc21	10.1016/j.bmc.2015.01.060
	122187376	122508	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	457	6	0	5	5.9	CCCCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	CHEMBL3609141	122508	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	457	6	0	5	5.9	CCCCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	9978683	18487	0	None	-380	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	406	3	1	5	3.3	CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)CC1	10.1021/jm1007825
	CHEMBL1277104	18487	0	None	-380	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	406	3	1	5	3.3	CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)CC1	10.1021/jm1007825
	53325861	56561	0	None	-2	3	Human	5.2	pKi	=	5.2	Binding	Inhibition of 5-HT2B receptor (unknown origin) by PDSP assayInhibition of 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	297	4	0	1	3.4	CN(CCc1cccc(F)c1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmc.2013.07.045
	CHEMBL1643902	56561	0	None	-2	3	Human	5.2	pKi	=	5.2	Binding	Inhibition of 5-HT2B receptor (unknown origin) by PDSP assayInhibition of 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	297	4	0	1	3.4	CN(CCc1cccc(F)c1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmc.2013.07.045
	53325861	56561	0	None	-2	3	Human	5.2	pKi	=	5.2	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	297	4	0	1	3.4	CN(CCc1cccc(F)c1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmcl.2010.11.075
	CHEMBL1643902	56561	0	None	-2	3	Human	5.2	pKi	=	5.2	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	297	4	0	1	3.4	CN(CCc1cccc(F)c1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmcl.2010.11.075
	117209858	183971	1	None	-3	7	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4848305	183971	1	None	-3	7	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	46230047	197570	0	None	16	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1ccc2c(c1)C(=O)NC1CNCCN21	10.1016/j.bmcl.2009.12.014
	CHEMBL590089	197570	0	None	16	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1ccc2c(c1)C(=O)NC1CNCCN21	10.1016/j.bmcl.2009.12.014
	24839550	136791	14	None	1	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	240	7	1	1	3.4	C=CCN(CC=C)CCc1c[nH]c2ccccc12	10.1016/j.bmcl.2015.12.053
	CHEMBL3752576	136791	14	None	1	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	240	7	1	1	3.4	C=CCN(CC=C)CCc1c[nH]c2ccccc12	10.1016/j.bmcl.2015.12.053
	45486891	195265	0	None	-83	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	449	6	3	4	4.1	O=C1Cc2c(ccc3c2OC[C@H](CNCCCC2CCc4c([nH]c5ccc(F)cc45)C2)O3)N1	10.1016/j.bmcl.2009.08.050
	CHEMBL566379	195265	0	None	-83	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	449	6	3	4	4.1	O=C1Cc2c(ccc3c2OC[C@H](CNCCCC2CCc4c([nH]c5ccc(F)cc45)C2)O3)N1	10.1016/j.bmcl.2009.08.050
	27620	140287	13	None	-269	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	297	5	0	2	3.8	O=C(CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818994	140287	13	None	-269	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	297	5	0	2	3.8	O=C(CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	24360	201653	101	None	-	1	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	348	1	1	6	2.1	CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3ccccc3nc2-1	nan
	CHEMBL65	201653	101	None	-	1	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	348	1	1	6	2.1	CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3ccccc3nc2-1	nan
	44315697	203794	0	None	-9	3	Human	7.2	pKi	=	7.2	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	254	4	1	3	2.6	CCSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	CHEMBL80731	203794	0	None	-9	3	Human	7.2	pKi	=	7.2	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	254	4	1	3	2.6	CCSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	3952	1857	33	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
	5353646	1857	33	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
	5443	1857	33	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
	5702063	1857	33	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
	CHEMBL1331786	1857	33	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
	CHEMBL420	1857	33	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
	145967771	164235	0	None	3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	223	2	2	4	1.6	C[C@H]1SC(c2ccccc2O)=N[C@@H]1CO	10.1021/acs.jnatprod.7b00317
	CHEMBL4218231	164235	0	None	3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	223	2	2	4	1.6	C[C@H]1SC(c2ccccc2O)=N[C@@H]1CO	10.1021/acs.jnatprod.7b00317
	57396813	71201	0	None	-891	5	Human	5.2	pKi	=	5.2	Binding	Inhibition of human 5HT2BInhibition of human 5HT2B	ChEMBL	403	5	1	6	3.2	COc1cc(OC(C)C)cc(S(=O)(=O)c2ccc3c(c2)O[C@H]2CNCC[C@@H]32)c1	10.1016/j.bmcl.2011.12.026
	CHEMBL1949930	71201	0	None	-891	5	Human	5.2	pKi	=	5.2	Binding	Inhibition of human 5HT2BInhibition of human 5HT2B	ChEMBL	403	5	1	6	3.2	COc1cc(OC(C)C)cc(S(=O)(=O)c2ccc3c(c2)O[C@H]2CNCC[C@@H]32)c1	10.1016/j.bmcl.2011.12.026
	CHEMBL1963007	71201	0	None	-891	5	Human	5.2	pKi	=	5.2	Binding	Inhibition of human 5HT2BInhibition of human 5HT2B	ChEMBL	403	5	1	6	3.2	COc1cc(OC(C)C)cc(S(=O)(=O)c2ccc3c(c2)O[C@H]2CNCC[C@@H]32)c1	10.1016/j.bmcl.2011.12.026
	44407335	72747	0	None	-7	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	321	5	1	3	4.7	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCC1CCCCC1	10.1016/j.bmcl.2005.10.029
	CHEMBL201117	72747	0	None	-7	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	321	5	1	3	4.7	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCC1CCCCC1	10.1016/j.bmcl.2005.10.029
	57799321	88632	1	None	-5	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@@H]2CNC[C@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337491	88632	1	None	-5	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@@H]2CNC[C@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2364961	88632	1	None	-5	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@@H]2CNC[C@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	71462777	82552	0	None	-83	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	335	5	0	4	4.3	CCCN1CCC(COc2nc3ccccc3c3ncccc23)CC1	10.1021/jm300943r
	CHEMBL2181171	82552	0	None	-83	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	335	5	0	4	4.3	CCCN1CCC(COc2nc3ccccc3c3ncccc23)CC1	10.1021/jm300943r
	56658156	65336	0	None	9	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	364	7	0	4	4.2	COc1ccccc1CCCN1CCN(Cc2cc3ccccc3o2)CC1	10.1016/j.bmcl.2011.08.029
	CHEMBL1834256	65336	0	None	9	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	364	7	0	4	4.2	COc1ccccc1CCCN1CCN(Cc2cc3ccccc3o2)CC1	10.1016/j.bmcl.2011.08.029
	168281486	190440	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	387	6	0	5	3.8	COc1cc2c(cc1OC)-c1c(OC)c(OCCF)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL5187013	190440	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	387	6	0	5	3.8	COc1cc2c(cc1OC)-c1c(OC)c(OCCF)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	11630147	90682	0	None	-3	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	246	2	1	3	1.1	CCOc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397908	90682	0	None	-3	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	246	2	1	3	1.1	CCOc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	44298209	192993	0	None	-19	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	395	3	1	5	4.5	Cc1cc2c(cc1Cl)N(C(=O)Nc1cnc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL53113	192993	0	None	-19	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	395	3	1	5	4.5	Cc1cc2c(cc1Cl)N(C(=O)Nc1cnc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	44298225	193807	0	None	-50	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	456	3	1	5	5.1	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3c2cc(C(F)(F)F)c2c3CCO2)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL55292	193807	0	None	-50	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	456	3	1	5	5.1	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3c2cc(C(F)(F)F)c2c3CCO2)cn1	10.1016/s0960-894x(00)00364-4
	44298244	198392	0	None	-79	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	438	3	1	4	5.2	Cc1cc2c(cc1Br)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL59584	198392	0	None	-79	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	438	3	1	4	5.2	Cc1cc2c(cc1Br)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	17989871	149792	0	None	-50	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	462	6	0	4	5.6	COc1ccc(N2Cc3cc(Cl)c(C)c(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	CHEMBL395298	149792	0	None	-50	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	462	6	0	4	5.6	COc1ccc(N2Cc3cc(Cl)c(C)c(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	10693974	35437	0	None	-9	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	431	3	1	3	5.5	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3ccc(F)cc3)c1)CC2	10.1021/jm990388c
	CHEMBL14401	35437	0	None	-9	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	431	3	1	3	5.5	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3ccc(F)cc3)c1)CC2	10.1021/jm990388c
	10458193	86414	0	None	-25	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	451	6	0	5	4.6	COc1ccc(N2Cc3c(c4cc(F)ccc4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
	CHEMBL232254	86414	0	None	-25	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	451	6	0	5	4.6	COc1ccc(N2Cc3c(c4cc(F)ccc4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
	44568347	191055	0	None	-30	15	Human	6.2	pKi	=	6.2	Binding	Antagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assay	ChEMBL	356	6	0	4	5.2	CCN(CC)CCCOC(=O)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
	CHEMBL519609	191055	0	None	-30	15	Human	6.2	pKi	=	6.2	Binding	Antagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assay	ChEMBL	356	6	0	4	5.2	CCN(CC)CCCOC(=O)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
	18475581	197918	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	318	2	2	4	4.3	Cc1nc2ccc(NC(=O)Nc3ccnc4ccccc34)cc2o1	10.1016/s0960-894x(01)00343-2
	CHEMBL59266	197918	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	318	2	2	4	4.3	Cc1nc2ccc(NC(=O)Nc3ccnc4ccccc34)cc2o1	10.1016/s0960-894x(01)00343-2
	24888180	79458	0	None	-251	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	426	7	0	4	4.6	COc1ccc(N2CC=C(c3cccc(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	CHEMBL212270	79458	0	None	-251	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	426	7	0	4	4.6	COc1ccc(N2CC=C(c3cccc(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	24887518	79874	0	None	-794	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	460	7	0	4	5.3	COc1ccc(N2CC=C(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	CHEMBL213987	79874	0	None	-794	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	460	7	0	4	5.3	COc1ccc(N2CC=C(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	44298091	101249	0	None	-99	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	398	3	1	4	5.0	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(F)c(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL299530	101249	0	None	-99	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	398	3	1	4	5.0	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(F)c(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
	10476876	193306	0	None	-158	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.2	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(C(F)(F)F)ccc32)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL54610	193306	0	None	-158	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.2	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(C(F)(F)F)ccc32)cn1	10.1016/s0960-894x(00)00364-4
	44298182	193327	0	None	-199	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	424	3	1	4	4.9	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Br)ccc32)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL54769	193327	0	None	-199	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	424	3	1	4	4.9	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Br)ccc32)cn1	10.1016/s0960-894x(00)00364-4
	10413595	161292	0	None	-1995	11	Human	6.2	pKi	=	6.2	Binding	Compound was evaluated for binding affinity against human cloned 5-HT2B receptor in HEK 293 cells using [3H]5-HT as the radioligandCompound was evaluated for binding affinity against human cloned 5-HT2B receptor in HEK 293 cells using [3H]5-HT as the radioligand	ChEMBL	499	4	1	5	2.5	COc1ccc(S(=O)(=O)N2CCc3ccc(I)cc32)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
	CHEMBL414628	161292	0	None	-1995	11	Human	6.2	pKi	=	6.2	Binding	Compound was evaluated for binding affinity against human cloned 5-HT2B receptor in HEK 293 cells using [3H]5-HT as the radioligandCompound was evaluated for binding affinity against human cloned 5-HT2B receptor in HEK 293 cells using [3H]5-HT as the radioligand	ChEMBL	499	4	1	5	2.5	COc1ccc(S(=O)(=O)N2CCc3ccc(I)cc32)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
	6918647	100278	2	None	-125	14	Human	6.2	pKi	=	6.2	Binding	Compound was tested for its binding affinity against cloned human 5-hydroxytryptamine 2B receptor in HEK 293 cells using [3H]5-HTCompound was tested for its binding affinity against cloned human 5-hydroxytryptamine 2B receptor in HEK 293 cells using [3H]5-HT	ChEMBL	439	5	1	5	3.0	COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1	10.1021/jm980532e
	CHEMBL292759	100278	2	None	-125	14	Human	6.2	pKi	=	6.2	Binding	Compound was tested for its binding affinity against cloned human 5-hydroxytryptamine 2B receptor in HEK 293 cells using [3H]5-HTCompound was tested for its binding affinity against cloned human 5-hydroxytryptamine 2B receptor in HEK 293 cells using [3H]5-HT	ChEMBL	439	5	1	5	3.0	COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1	10.1021/jm980532e
	18931344	204808	0	None	-19	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	544	11	3	8	2.5	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccccc1	10.1016/S0960-894X(96)00503-3
	CHEMBL88571	204808	0	None	-19	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	544	11	3	8	2.5	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccccc1	10.1016/S0960-894X(96)00503-3
	155557042	173985	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	1	1	3	1.9	COc1ccc2c(c1)[C@@H]1CCN[C@]1(C)CO2	10.1021/acsmedchemlett.9b00225
	CHEMBL4556297	173985	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	1	1	3	1.9	COc1ccc2c(c1)[C@@H]1CCN[C@]1(C)CO2	10.1021/acsmedchemlett.9b00225
	15124	140604	6	None	1	4	Human	5.2	pKi	=	5.2	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	204	3	2	2	2.0	CN(C)CCc1c[nH]c2cc(O)ccc12	10.1016/j.bmcl.2005.06.104
	CHEMBL382750	140604	6	None	1	4	Human	5.2	pKi	=	5.2	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	204	3	2	2	2.0	CN(C)CCc1c[nH]c2cc(O)ccc12	10.1016/j.bmcl.2005.06.104
	118055308	177188	0	None	-2	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	208	0	1	2	1.8	Clc1ccc2c3c1CCN3CCNC2	10.1016/j.bmcl.2019.126929
	CHEMBL4642763	177188	0	None	-2	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	208	0	1	2	1.8	Clc1ccc2c3c1CCN3CCNC2	10.1016/j.bmcl.2019.126929
	2099	9217	49	None	-	1	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	nan
	CHEMBL1110	9217	49	None	-	1	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	nan
	25209050	181008	0	None	-3	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	479	6	2	6	3.9	Cc1c(Cn2ncc(N3CCNCC3)cc2=O)cccc1NC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
	CHEMBL477008	181008	0	None	-3	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	479	6	2	6	3.9	Cc1c(Cn2ncc(N3CCNCC3)cc2=O)cccc1NC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
	11820166	40035	0	None	-5	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	202	2	2	2	2.0	COc1cccc2[nH]cc(C3CC3N)c12	10.1021/jm980318q
	CHEMBL148091	40035	0	None	-5	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	202	2	2	2	2.0	COc1cccc2[nH]cc(C3CC3N)c12	10.1021/jm980318q
	70695812	72937	0	None	-831	8	Human	6.2	pKi	=	6.2	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	375	5	3	7	2.0	O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NC(C3CC3)C3CC3)nc(Cl)nc21	10.1021/acs.jmedchem.8b01662
	CHEMBL2012686	72937	0	None	-831	8	Human	6.2	pKi	=	6.2	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	375	5	3	7	2.0	O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NC(C3CC3)C3CC3)nc(Cl)nc21	10.1021/acs.jmedchem.8b01662
	71062560	152894	0	None	-1	2	Mouse	5.2	pKi	=	5.2	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	352	5	0	4	2.4	O=C(CN1CCO[C@H](COc2ccccc2)C1)N1CCc2ccccc21	nan
	CHEMBL3979116	152894	0	None	-1	2	Mouse	5.2	pKi	=	5.2	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	352	5	0	4	2.4	O=C(CN1CCO[C@H](COc2ccccc2)C1)N1CCc2ccccc21	nan
	59511191	184941	3	None	-8	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4862745	184941	3	None	-8	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	44276349	99542	0	None	-288	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	325	3	4	8	-0.2	CNc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12	10.1021/acs.jmedchem.6b01183
	CHEMBL286739	99542	0	None	-288	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	325	3	4	8	-0.2	CNc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12	10.1021/acs.jmedchem.6b01183
	11427139	84263	0	None	-15	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	282	1	1	2	2.4	C=Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL222566	84263	0	None	-15	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	282	1	1	2	2.4	C=Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	2274	3124	53	None	-10	32	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	4917	3124	53	None	-10	32	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	7279	3124	53	None	-10	32	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	CHEMBL728	3124	53	None	-10	32	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	DB00433	3124	53	None	-10	32	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	132060812	161487	0	None	-16	10	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	329	4	0	2	4.9	COc1cccc(-c2ccc3c(c2)CCN(Cc2ccccc2)C3)c1	10.1016/j.ejmech.2018.02.024
	CHEMBL4160064	161487	0	None	-16	10	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	329	4	0	2	4.9	COc1cccc(-c2ccc3c(c2)CCN(Cc2ccccc2)C3)c1	10.1016/j.ejmech.2018.02.024
	44215629	155801	1	None	-12	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	206	0	1	2	1.9	N#Cc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
	CHEMBL406585	155801	1	None	-12	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	206	0	1	2	1.9	N#Cc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
	118729236	120166	0	None	-9	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccccc2Br)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402658	120166	0	None	-9	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccccc2Br)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547011	120166	0	None	-9	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccccc2Br)C1	10.1016/j.bmc.2015.01.060
	CHEMBL4513786	212217	5	None	-1174	8	Human	5.2	pKi	=	5.2	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000289bCl HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000289bCl HTR2B	ChEMBL		None	None	None		CCCCN(CCCC)C(=O)CN1C[C@@H](c2cc(OC)c3c(c2)OCO3)[C@H](C(=O)O)[C@H]1CC(C)(C)CCC	nan
	CHEMBL4796803	212217	5	None	-1174	8	Human	5.2	pKi	=	5.2	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000289bCl HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000289bCl HTR2B	ChEMBL		None	None	None		CCCCN(CCCC)C(=O)CN1C[C@@H](c2cc(OC)c3c(c2)OCO3)[C@H](C(=O)O)[C@H]1CC(C)(C)CCC	nan
	46914776	15244	0	None	7	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	364	7	0	4	4.5	CCCOc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
	CHEMBL1214892	15244	0	None	7	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	364	7	0	4	4.5	CCCOc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
	71062708	153772	0	None	-3	12	Mouse	6.2	pKi	=	6.2	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	368	7	0	5	2.8	COc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
	CHEMBL3986651	153772	0	None	-3	12	Mouse	6.2	pKi	=	6.2	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	368	7	0	5	2.8	COc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
	49865886	16004	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	262	2	1	3	2.1	CCCNC(=O)N1OCC2COc3ccccc3C21	10.1016/j.bmcl.2010.07.074
	CHEMBL1224102	16004	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	262	2	1	3	2.1	CCCNC(=O)N1OCC2COc3ccccc3C21	10.1016/j.bmcl.2010.07.074
	11198145	9722	2	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
	CHEMBL113830	9722	2	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
	49783209	17427	0	None	-114	27	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
	CHEMBL1258223	17427	0	None	-114	27	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
	10539928	120195	0	None	-8	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(F)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402668	120195	0	None	-8	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(F)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547154	120195	0	None	-8	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(F)cc2)C1	10.1016/j.bmc.2015.01.060
	136118619	75898	0	None	2	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3c(Br)cccc23)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2058418	75898	0	None	2	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3c(Br)cccc23)N1C	10.1016/j.bmc.2013.09.011
	25060119	103837	0	None	-9332	7	Human	6.2	pKi	=	6.2	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	493	7	1	5	6.1	COc1ccc(CNC(=O)c2cc(-c3cc(Cl)cc(Cl)c3)cnc2-c2cccnc2)cc1OC	10.1016/j.bmcl.2013.10.045
	CHEMBL3099899	103837	0	None	-9332	7	Human	6.2	pKi	=	6.2	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	493	7	1	5	6.1	COc1ccc(CNC(=O)c2cc(-c3cc(Cl)cc(Cl)c3)cnc2-c2cccnc2)cc1OC	10.1016/j.bmcl.2013.10.045
	122187377	122509	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	485	8	0	5	6.7	CCCCCCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	CHEMBL3609142	122509	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	485	8	0	5	6.7	CCCCCCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	CHEMBL5071978	212501	0	None	1	6	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCN(CC)Cc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	44397752	124749	0	None	-7	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	216	0	1	2	2.0	Cc1ccc2c(c1C)N1[C@H](CNC[C@H]1C)C2	10.1016/j.bmcl.2005.05.074
	CHEMBL364534	124749	0	None	-7	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	216	0	1	2	2.0	Cc1ccc2c(c1C)N1[C@H](CNC[C@H]1C)C2	10.1016/j.bmcl.2005.05.074
	46230097	197685	0	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.6	O=C1NC2CCNCCN2c2ccccc21	10.1016/j.bmcl.2009.12.014
	CHEMBL590816	197685	0	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.6	O=C1NC2CCNCCN2c2ccccc21	10.1016/j.bmcl.2009.12.014
	130442480	174698	0	None	-83	24	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	CHEMBL4572614	174698	0	None	-83	24	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	134150123	151558	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	381	4	2	9	0.4	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N(C)C)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3967613	151558	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	381	4	2	9	0.4	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N(C)C)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	3033538	1292	36	None	-12	9	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
	7155	1292	36	None	-12	9	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
	781	1292	36	None	-12	9	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
	CHEMBL1201216	1292	36	None	-12	9	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
	DB00298	1292	36	None	-12	9	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
	16118795	59780	0	None	-954	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	406	4	3	5	3.7	O=S(=O)(c1cccc2ccccc12)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
	CHEMBL1642851	59780	0	None	-954	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	406	4	3	5	3.7	O=S(=O)(c1cccc2ccccc12)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
	CHEMBL1739215	59780	0	None	-954	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	406	4	3	5	3.7	O=S(=O)(c1cccc2ccccc12)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
	16117153	59823	0	None	-1122	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	406	4	3	5	3.7	O=S(=O)(c1ccc2ccccc2c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
	CHEMBL1642889	59823	0	None	-1122	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	406	4	3	5	3.7	O=S(=O)(c1ccc2ccccc2c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
	CHEMBL1739616	59823	0	None	-1122	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	406	4	3	5	3.7	O=S(=O)(c1ccc2ccccc2c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
	70695812	72937	0	None	-831	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	375	5	3	7	2.0	O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NC(C3CC3)C3CC3)nc(Cl)nc21	10.1021/acs.jmedchem.6b01183
	CHEMBL2012686	72937	0	None	-831	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	375	5	3	7	2.0	O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NC(C3CC3)C3CC3)nc(Cl)nc21	10.1021/acs.jmedchem.6b01183
	44352308	116984	0	None	-83	12	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human 5-hydroxytryptamine 2B receptor using [3H]5-HT as radioligandBinding affinity towards human 5-hydroxytryptamine 2B receptor using [3H]5-HT as radioligand	ChEMBL	339	5	2	2	4.0	Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C	10.1021/jm0155190
	CHEMBL339980	116984	0	None	-83	12	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human 5-hydroxytryptamine 2B receptor using [3H]5-HT as radioligandBinding affinity towards human 5-hydroxytryptamine 2B receptor using [3H]5-HT as radioligand	ChEMBL	339	5	2	2	4.0	Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C	10.1021/jm0155190
	122442272	137820	0	None	-2	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human 5HT2B receptor by radioligand binding assayBinding affinity to human 5HT2B receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769968	137820	0	None	-2	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human 5HT2B receptor by radioligand binding assayBinding affinity to human 5HT2B receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771384	137820	0	None	-2	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human 5HT2B receptor by radioligand binding assayBinding affinity to human 5HT2B receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	213	3792	50	None	-3	43	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
	2717	3792	50	None	-3	43	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
	5533	3792	50	None	-3	43	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
	CHEMBL621	3792	50	None	-3	43	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
	DB00656	3792	50	None	-3	43	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
	44409097	76253	0	None	-4	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	257	0	1	3	1.8	C[C@@H]1CNC[C@H]2Cc3ccc(C(F)(F)F)nc3N12	10.1016/j.bmcl.2005.11.083
	CHEMBL206333	76253	0	None	-4	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	257	0	1	3	1.8	C[C@@H]1CNC[C@H]2Cc3ccc(C(F)(F)F)nc3N12	10.1016/j.bmcl.2005.11.083
	44626329	195732	0	None	-20	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	420	3	2	4	3.7	O=c1[nH]c2cccc(N3CCN(CC4CCc5[nH]c6ccc(F)cc6c5C4)CC3)c2o1	10.1016/j.bmcl.2009.08.050
	CHEMBL569513	195732	0	None	-20	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	420	3	2	4	3.7	O=c1[nH]c2cccc(N3CCN(CC4CCc5[nH]c6ccc(F)cc6c5C4)CC3)c2o1	10.1016/j.bmcl.2009.08.050
	11148641	90659	0	None	-1	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@H]1CN2C(=O)c3ccccc3C[C@@H]2CN1	10.1016/j.bmcl.2013.04.061
	CHEMBL2397885	90659	0	None	-1	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@H]1CN2C(=O)c3ccccc3C[C@@H]2CN1	10.1016/j.bmcl.2013.04.061
	CHEMBL5091373	213791	0	None	-33	9	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095981	213791	0	None	-33	9	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	2351	3234	60	None	-7	21	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1021/jm100600y
	2820	3234	60	None	-7	21	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1021/jm100600y
	5035	3234	60	None	-7	21	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1021/jm100600y
	CHEMBL81	3234	60	None	-7	21	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1021/jm100600y
	DB00481	3234	60	None	-7	21	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1021/jm100600y
	122442272	137820	0	None	-2	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human 5HT2B receptor by radioligand binding assayBinding affinity to human 5HT2B receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769968	137820	0	None	-2	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human 5HT2B receptor by radioligand binding assayBinding affinity to human 5HT2B receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771384	137820	0	None	-2	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human 5HT2B receptor by radioligand binding assayBinding affinity to human 5HT2B receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	9909648	203861	1	None	-22	12	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	340	4	0	3	3.7	Fc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1	10.1021/jm100600y
	CHEMBL81330	203861	1	None	-22	12	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	340	4	0	3	3.7	Fc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1	10.1021/jm100600y
	145977799	163091	0	None	1	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	CHEMBL4204036	163091	0	None	1	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	12488	1627	51	None	-11	23	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
	941361	1627	51	None	-11	23	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
	CHEMBL30008	1627	51	None	-11	23	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
	DB04841	1627	51	None	-11	23	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
	53324553	56560	0	None	-9	10	Human	5.2	pKi	=	5.2	Binding	Inhibition of 5-HT2B receptor (unknown origin) by PDSP assayInhibition of 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmc.2013.07.045
	CHEMBL1643900	56560	0	None	-9	10	Human	5.2	pKi	=	5.2	Binding	Inhibition of 5-HT2B receptor (unknown origin) by PDSP assayInhibition of 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmc.2013.07.045
	53324553	56560	0	None	-9	10	Human	5.2	pKi	=	5.2	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmcl.2010.11.075
	CHEMBL1643900	56560	0	None	-9	10	Human	5.2	pKi	=	5.2	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmcl.2010.11.075
	16115271	78698	0	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	298	1	1	2	2.8	CC(C)[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	CHEMBL2113264	78698	0	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	298	1	1	2	2.8	CC(C)[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	71720492	86540	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	493	8	2	5	3.0	C=CCN1C[C@H](C(=O)N(CCCN2CCOCC2)C(=O)NCC)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/ml3003814
	CHEMBL2323578	86540	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	493	8	2	5	3.0	C=CCN1C[C@H](C(=O)N(CCCN2CCOCC2)C(=O)NCC)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/ml3003814
	135398737	944	89	None	-2	91	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	38	944	89	None	-2	91	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	722	944	89	None	-2	91	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	CHEMBL42	944	89	None	-2	91	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	DB00363	944	89	None	-2	91	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	9803032	190857	0	None	-12	3	Human	8.1	pKi	=	8.1	Binding	Binding affinity to 5-HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	435	7	0	4	4.4	COc1ccccc1N1CCN(CC[C@@H](C(=O)N2CCCCCC2)c2ccccc2)CC1	10.1021/acs.jmedchem.2c00633
	CHEMBL5193178	190857	0	None	-12	3	Human	8.1	pKi	=	8.1	Binding	Binding affinity to 5-HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	435	7	0	4	4.4	COc1ccccc1N1CCN(CC[C@@H](C(=O)N2CCCCCC2)c2ccccc2)CC1	10.1021/acs.jmedchem.2c00633
	3649661	137691	6	None	23	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	329	3	3	7	2.2	CCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770106	137691	6	None	23	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	329	3	3	7	2.2	CCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	2247	502	77	None	-4	41	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	249	502	77	None	-4	41	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	2603	502	77	None	-4	41	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	CHEMBL296419	502	77	None	-4	41	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	DB00637	502	77	None	-4	41	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	11708275	72367	3	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	205	3	1	4	1.4	COc1ccc2cnn(C[C@H](C)N)c2c1	10.1021/jm050663x
	CHEMBL199775	72367	3	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	205	3	1	4	1.4	COc1ccc2cnn(C[C@H](C)N)c2c1	10.1021/jm050663x
	134	2478	19	None	-2	67	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
	1775	2478	19	None	-2	67	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
	9681	2478	19	None	-2	67	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
	CHEMBL1065	2478	19	None	-2	67	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
	DB00247	2478	19	None	-2	67	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
	134	2478	19	None	-2	67	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
	1775	2478	19	None	-2	67	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
	9681	2478	19	None	-2	67	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
	CHEMBL1065	2478	19	None	-2	67	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
	DB00247	2478	19	None	-2	67	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
	11949710	198220	0	None	-5	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from human 5HT2B receptor expressed in CHO cells	ChEMBL	355	4	1	4	3.5	Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL594717	198220	0	None	-5	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from human 5HT2B receptor expressed in CHO cells	ChEMBL	355	4	1	4	3.5	Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21	10.1016/j.bmcl.2009.10.112
	36906	104401	68	None	-1	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	204	3	2	2	2.1	COc1ccc2[nH]cc(CC(C)N)c2c1	10.1021/jm050663x
	CHEMBL31115	104401	68	None	-1	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	204	3	2	2	2.1	COc1ccc2[nH]cc(CC(C)N)c2c1	10.1021/jm050663x
	36906	104401	68	None	-1	5	Human	8.1	pKi	=	8.1	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	204	3	2	2	2.1	COc1ccc2[nH]cc(CC(C)N)c2c1	10.1021/jm030205t
	CHEMBL31115	104401	68	None	-1	5	Human	8.1	pKi	=	8.1	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	204	3	2	2	2.1	COc1ccc2[nH]cc(CC(C)N)c2c1	10.1021/jm030205t
	44573547	187049	0	None	-11	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-HT2B expressed in HEK293 cells assessed as inhibition constant by radioligand binding assayBinding affinity to human recombinant 5-HT2B expressed in HEK293 cells assessed as inhibition constant by radioligand binding assay	ChEMBL	348	5	1	5	2.6	C[C@H](Cc1cccc(F)c1)Oc1nc(N2CCNC[C@H]2C)ncc1F	10.1021/acs.jmedchem.2c00633
	CHEMBL494948	187049	0	None	-11	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-HT2B expressed in HEK293 cells assessed as inhibition constant by radioligand binding assayBinding affinity to human recombinant 5-HT2B expressed in HEK293 cells assessed as inhibition constant by radioligand binding assay	ChEMBL	348	5	1	5	2.6	C[C@H](Cc1cccc(F)c1)Oc1nc(N2CCNC[C@H]2C)ncc1F	10.1021/acs.jmedchem.2c00633
	9931534	33887	0	None	-7	3	Human	8.1	pKi	=	8.1	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	413	3	1	3	5.4	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3)c1)CC2	10.1021/jm990388c
	CHEMBL14255	33887	0	None	-7	3	Human	8.1	pKi	=	8.1	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	413	3	1	3	5.4	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3)c1)CC2	10.1021/jm990388c
	10623205	98610	0	None	-12	3	Human	8.1	pKi	=	8.1	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	445	3	1	3	5.8	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(F)c(C)c(-c3cccnc3)c1)CC2	10.1021/jm990388c
	CHEMBL280465	98610	0	None	-12	3	Human	8.1	pKi	=	8.1	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	445	3	1	3	5.8	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(F)c(C)c(-c3cccnc3)c1)CC2	10.1021/jm990388c
	10837468	162158	0	None	-15	3	Human	8.1	pKi	=	8.1	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	455	3	1	4	5.3	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc3c(c(-c4cccnc4)c1)OCC3)CC2	10.1021/jm990388c
	CHEMBL417082	162158	0	None	-15	3	Human	8.1	pKi	=	8.1	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	455	3	1	4	5.3	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc3c(c(-c4cccnc4)c1)OCC3)CC2	10.1021/jm990388c
	10622480	166483	0	None	-5	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	429	3	1	3	6.1	CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3)c1)CC2	10.1021/jm990388c
	CHEMBL428879	166483	0	None	-5	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	429	3	1	3	6.1	CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3)c1)CC2	10.1021/jm990388c
	44298176	100161	0	None	-6	3	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	394	4	1	4	4.6	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3ccncc3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL291949	100161	0	None	-6	3	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	394	4	1	4	4.6	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3ccncc3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	18357730	194235	0	None	-19	3	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	442	4	1	4	5.3	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cnc(OCc3ccccn3)c(C)c1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL55914	194235	0	None	-19	3	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	442	4	1	4	5.3	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cnc(OCc3ccccn3)c(C)c1)CC2	10.1016/s0960-894x(00)00365-6
	44453103	97611	0	None	-3	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity at 5HT2B receptorBinding affinity at 5HT2B receptor	ChEMBL	296	4	1	4	2.9	CCN(CC)c1nc2c(c(-c3ccc(C)cc3)n1)CNCC2	10.1016/j.bmcl.2008.01.090
	CHEMBL273173	97611	0	None	-3	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity at 5HT2B receptorBinding affinity at 5HT2B receptor	ChEMBL	296	4	1	4	2.9	CCN(CC)c1nc2c(c(-c3ccc(C)cc3)n1)CNCC2	10.1016/j.bmcl.2008.01.090
	240	931	39	None	-6	25	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
	2769	931	39	None	-6	25	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
	44279790	931	39	None	-6	25	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
	660	931	39	None	-6	25	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
	CHEMBL1729	931	39	None	-6	25	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
	CHEMBL560739	931	39	None	-6	25	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
	DB00604	931	39	None	-6	25	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
	11737939	83812	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	256	0	1	2	2.1	O=C1c2c(ccc(Cl)c2Cl)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL220900	83812	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	256	0	1	2	2.1	O=C1c2c(ccc(Cl)c2Cl)[C@@H]2CNCCN12	10.1021/jm0612968
	118729268	120189	0	None	-22	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(F)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402677	120189	0	None	-22	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(F)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547138	120189	0	None	-22	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(F)c2)C1	10.1016/j.bmc.2015.01.060
	118729254	120196	0	None	-6	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	296	3	0	3	3.6	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc([N+](=O)[O-])c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402669	120196	0	None	-6	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	296	3	0	3	3.6	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc([N+](=O)[O-])c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547155	120196	0	None	-6	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	296	3	0	3	3.6	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc([N+](=O)[O-])c2)C1	10.1016/j.bmc.2015.01.060
	16062136	157126	4	None	-13	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	285	1	1	3	3.2	CC(C)(C)c1nc2c(c(-c3ccc(F)cc3)n1)CNCC2	10.1016/j.bmcl.2008.01.090
	CHEMBL408155	157126	4	None	-13	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	285	1	1	3	3.2	CC(C)(C)c1nc2c(c(-c3ccc(F)cc3)n1)CNCC2	10.1016/j.bmcl.2008.01.090
	146159245	187866	27	None	-	1	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	nan
	451415	187866	27	None	-	1	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	nan
	86289437	187866	27	None	-	1	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	nan
	CHEMBL502620	187866	27	None	-	1	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	nan
	12613159	186743	7	None	-2	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
	CHEMBL493054	186743	7	None	-2	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
	10517285	120200	0	None	-14	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccccc2Cl)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402683	120200	0	None	-14	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccccc2Cl)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547176	120200	0	None	-14	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccccc2Cl)C1	10.1016/j.bmc.2015.01.060
	1224	1404	79	None	-6	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	3100	1404	79	None	-6	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	8980	1404	79	None	-6	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	916	1404	79	None	-6	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	CHEMBL657	1404	79	None	-6	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	DB01075	1404	79	None	-6	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	122187381	122512	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	401	2	1	5	4.5	COc1cc2c3c(c1O)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	CHEMBL3609146	122512	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	401	2	1	5	4.5	COc1cc2c3c(c1O)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	135465870	188404	7	None	3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	254	1	2	2	1.6	C/N=C1\NC(=O)/C(=C\c2c[nH]c3ccccc23)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL508657	188404	7	None	3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	254	1	2	2	1.6	C/N=C1\NC(=O)/C(=C\c2c[nH]c3ccccc23)N1C	10.1016/j.bmc.2013.09.011
	155565326	175012	0	None	-467	7	Human	6.1	pKi	=	6.1	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	462	6	5	9	0.5	O=C(NCCO)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@H]4C[C@H]5CC[C@@H]4C5)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	CHEMBL4579650	175012	0	None	-467	7	Human	6.1	pKi	=	6.1	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	462	6	5	9	0.5	O=C(NCCO)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@H]4C[C@H]5CC[C@@H]4C5)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	46914620	15259	0	None	6	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	350	6	0	4	4.1	CCOc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
	CHEMBL1214962	15259	0	None	6	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	350	6	0	4	4.1	CCOc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
	46230094	197631	0	None	5	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	237	0	2	3	0.8	O=C1NC2CNCCN2c2ccc(Cl)cc21	10.1016/j.bmcl.2009.12.014
	CHEMBL590482	197631	0	None	5	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	237	0	2	3	0.8	O=C1NC2CNCCN2c2ccc(Cl)cc21	10.1016/j.bmcl.2009.12.014
	57403525	69811	0	None	-478	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	361	6	1	2	4.8	OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	CHEMBL1940402	69811	0	None	-478	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	361	6	1	2	4.8	OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	127051845	140198	0	None	-42	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	309	6	0	3	3.7	COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3817898	140198	0	None	-42	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	309	6	0	3	3.7	COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	4178	194130	58	None	-	1	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	179	3	1	2	2.0	Cc1cccc(C)c1OCC(C)N	nan
	CHEMBL558	194130	58	None	-	1	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	179	3	1	2	2.0	Cc1cccc(C)c1OCC(C)N	nan
	127051845	140198	0	None	-42	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	309	6	0	3	3.7	COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3817898	140198	0	None	-42	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	309	6	0	3	3.7	COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	145986752	166723	0	None	-1	17	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	562	10	1	5	7.3	COc1ccc(N(CCCCN2CCC(O)(c3ccc(Cl)c(C(F)(F)F)c3)CC2)c2ccc(OC)cc2)cc1	10.1016/j.bmcl.2018.10.036
	CHEMBL4293307	166723	0	None	-1	17	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	562	10	1	5	7.3	COc1ccc(N(CCCCN2CCC(O)(c3ccc(Cl)c(C(F)(F)F)c3)CC2)c2ccc(OC)cc2)cc1	10.1016/j.bmcl.2018.10.036
	11695000	88642	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337490	88642	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365083	88642	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	118729276	120177	0	None	-14	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	327	3	0	1	5.4	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(-c3ccccc3)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402682	120177	0	None	-14	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	327	3	0	1	5.4	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(-c3ccccc3)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547045	120177	0	None	-14	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	327	3	0	1	5.4	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(-c3ccccc3)c2)C1	10.1016/j.bmc.2015.01.060
	134152157	152605	0	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	393	6	4	8	1.4	CC[C@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1021/acs.jmedchem.6b01183
	CHEMBL3976579	152605	0	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	393	6	4	8	1.4	CC[C@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1021/acs.jmedchem.6b01183
	21830793	91403	5	None	-489	46	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	10.1016/j.bmc.2013.05.050
	CHEMBL2413154	91403	5	None	-489	46	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	10.1016/j.bmc.2013.05.050
	16115392	84373	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	236	0	1	2	1.7	Cc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL223292	84373	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	236	0	1	2	1.7	Cc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	11665991	197664	0	None	2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	251	0	2	3	1.2	O=C1NC2CNCCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
	CHEMBL590721	197664	0	None	2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	251	0	2	3	1.2	O=C1NC2CNCCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
	222757	98917	70	None	-1	3	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	376	2	1	3	5.1	C[C@]12CC[C@@H]3c4ccc(OC(=O)c5ccccc5)cc4CC[C@H]3[C@@H]1CC[C@@H]2O	nan
	CHEMBL282575	98917	70	None	-1	3	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	376	2	1	3	5.1	C[C@]12CC[C@@H]3c4ccc(OC(=O)c5ccccc5)cc4CC[C@H]3[C@@H]1CC[C@@H]2O	nan
	2812	4711	96	None	-40	34	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
	CHEMBL104	4711	96	None	-40	34	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
	44407440	138776	0	None	-4	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	329	5	1	3	4.7	Cc1ccccc1CN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL379223	138776	0	None	-4	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	329	5	1	3	4.7	Cc1ccccc1CN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	24740863	88728	0	None	1	6	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	385	6	1	5	5.0	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1Cl	10.1016/j.bmcl.2009.09.024
	CHEMBL236610	88728	0	None	1	6	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	385	6	1	5	5.0	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1Cl	10.1016/j.bmcl.2009.09.024
	46214153	110206	0	None	-6	5	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	367	5	1	3	4.0	Clc1cccc(COc2ccc(Br)cc2OC2CNC2)c1	10.1021/ml500082j
	CHEMBL3260334	110206	0	None	-6	5	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	367	5	1	3	4.0	Clc1cccc(COc2ccc(Br)cc2OC2CNC2)c1	10.1021/ml500082j
	11221167	84257	0	None	-10	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL222514	84257	0	None	-10	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL4520788	212225	6	None	-3	25	Human	7.1	pKi	=	7.1	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000743a HTR2B	ChEMBL		None	None	None		CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1	nan
	155535754	171509	0	None	13	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	301	1	1	4	1.2	Cc1cccc(C)c1N1C(=O)CNC2(CCN(C)CC2)C1=O	10.1016/j.ejmech.2018.12.048
	CHEMBL4472251	171509	0	None	13	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	301	1	1	4	1.2	Cc1cccc(C)c1N1C(=O)CNC2(CCN(C)CC2)C1=O	10.1016/j.ejmech.2018.12.048
	44404906	69927	0	None	-5	3	Human	6.1	pKi	=	6.1	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	218	3	2	2	2.4	CC(Cc1c[nH]c2cccc(O)c12)N(C)C	10.1016/j.bmcl.2005.06.104
	CHEMBL194202	69927	0	None	-5	3	Human	6.1	pKi	=	6.1	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	218	3	2	2	2.4	CC(Cc1c[nH]c2cccc(O)c12)N(C)C	10.1016/j.bmcl.2005.06.104
	24873261	182612	0	None	-1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	241	2	1	3	2.3	CCn1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4795756	182612	0	None	-1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	241	2	1	3	2.3	CCn1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
	16115644	136437	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	246	2	1	3	1.4	CCc1cc2c(cc1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL374436	136437	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	246	2	1	3	1.4	CCc1cc2c(cc1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	145964150	163754	0	None	-3	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	279	6	1	4	3.1	CCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1	10.1021/acs.jnatprod.7b00317
	CHEMBL4212246	163754	0	None	-3	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	279	6	1	4	3.1	CCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1	10.1021/acs.jnatprod.7b00317
	118567543	170802	0	None	-7	3	Human	6.1	pKi	=	6.1	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	463	4	0	4	4.2	O=C1N(c2cccnc2C(F)(F)F)CC2(CCN(CCc3ccccc3F)CC2)OC12CC2	10.1021/acs.jmedchem.9b01256
	CHEMBL4461774	170802	0	None	-7	3	Human	6.1	pKi	=	6.1	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	463	4	0	4	4.2	O=C1N(c2cccnc2C(F)(F)F)CC2(CCN(CCc3ccccc3F)CC2)OC12CC2	10.1021/acs.jmedchem.9b01256
	88912137	110209	0	None	-245	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	405	5	1	3	5.2	C[C@@H](Oc1ccc(C(F)(F)F)cc1OC1CNC1)c1cccc(C(F)(F)F)c1	10.1021/ml500082j
	CHEMBL3260337	110209	0	None	-245	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	405	5	1	3	5.2	C[C@@H](Oc1ccc(C(F)(F)F)cc1OC1CNC1)c1cccc(C(F)(F)F)c1	10.1021/ml500082j
	122188580	122669	0	None	-19	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	485	5	4	8	2.4	CCCNc1cc(C#Cc2ccc(Cl)s2)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(C(=O)NC)C[C@H]12	10.1021/acsmedchemlett.9b00637
	CHEMBL3612941	122669	0	None	-19	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	485	5	4	8	2.4	CCCNc1cc(C#Cc2ccc(Cl)s2)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(C(=O)NC)C[C@H]12	10.1021/acsmedchemlett.9b00637
	71062889	147742	0	None	-41	5	Mouse	5.1	pKi	=	5.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	353	5	0	5	1.8	O=C(CN1CCO[C@H](COc2cccnc2)C1)N1CCc2ccccc21	nan
	CHEMBL3936595	147742	0	None	-41	5	Mouse	5.1	pKi	=	5.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	353	5	0	5	1.8	O=C(CN1CCO[C@H](COc2cccnc2)C1)N1CCc2ccccc21	nan
	44409096	76422	0	None	-28	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	203	0	1	3	1.1	Cc1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
	CHEMBL206845	76422	0	None	-28	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	203	0	1	3	1.1	Cc1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
	134138769	147138	0	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	419	6	4	8	1.7	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@@H](C4CCC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3931747	147138	0	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	419	6	4	8	1.7	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@@H](C4CCC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	132559161	172453	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5HT2b (unknown origin)Binding affinity to 5HT2b (unknown origin)	ChEMBL	538	7	2	7	1.8	CC(C)[C@@H]1NC(=O)[C@H](Cc2ccoc2)N(C)C(=O)[C@H](Cc2ccoc2)NC(=O)[C@H](Cc2ccoc2)N(C)C1=O	10.1039/C9MD00050J
	CHEMBL4518571	172453	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5HT2b (unknown origin)Binding affinity to 5HT2b (unknown origin)	ChEMBL	538	7	2	7	1.8	CC(C)[C@@H]1NC(=O)[C@H](Cc2ccoc2)N(C)C(=O)[C@H](Cc2ccoc2)NC(=O)[C@H](Cc2ccoc2)N(C)C1=O	10.1039/C9MD00050J
	90181066	159616	0	None	9	2	Mouse	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	380	5	0	4	3.1	Cc1ccccc1OC[C@H]1CN(CC(=O)N2c3ccccc3CC2C)CCO1	nan
	CHEMBL4109218	159616	0	None	9	2	Mouse	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	380	5	0	4	3.1	Cc1ccccc1OC[C@H]1CN(CC(=O)N2c3ccccc3CC2C)CCO1	nan
	136118652	92621	0	None	3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3cccc(Br)c23)C(=O)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2442266	92621	0	None	3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3cccc(Br)c23)C(=O)N1C	10.1016/j.bmc.2013.09.011
	11673842	88659	0	None	-1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	264	2	2	2	2.1	CCCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337498	88659	0	None	-1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	264	2	2	2	2.1	CCCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365254	88659	0	None	-1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	264	2	2	2	2.1	CCCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	11361103	90674	1	None	-1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	270	0	1	2	1.7	O=C1c2ccc(C(F)(F)F)cc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397900	90674	1	None	-1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	270	0	1	2	1.7	O=C1c2ccc(C(F)(F)F)cc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	18715554	74075	0	None	-10	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3cnccc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL202656	74075	0	None	-10	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3cnccc3c21	10.1016/j.bmcl.2005.10.029
	24826871	90681	0	None	1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	232	1	1	3	0.7	COc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397907	90681	0	None	1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	232	1	1	3	0.7	COc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	25122653	198843	0	None	-17	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	440	3	2	5	4.1	NC1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5c(Cl)cccc45)c3c2)CC1	10.1021/jm901674f
	CHEMBL598850	198843	0	None	-17	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	440	3	2	5	4.1	NC1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5c(Cl)cccc45)c3c2)CC1	10.1021/jm901674f
	136118638	75963	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	335	1	2	3	3.1	CSC1=NC(=O)/C(=C/c2c[nH]c3cccc(Br)c23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2058698	75963	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	335	1	2	3	3.1	CSC1=NC(=O)/C(=C/c2c[nH]c3cccc(Br)c23)N1	10.1016/j.bmc.2013.09.011
	136118730	75891	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2cccc(Br)c12	10.1016/j.bmc.2013.09.011
	CHEMBL2058407	75891	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2cccc(Br)c12	10.1016/j.bmc.2013.09.011
	71062567	159868	0	None	2	2	Mouse	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	353	6	0	5	2.5	Cc1ccnc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
	CHEMBL4111349	159868	0	None	2	2	Mouse	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	353	6	0	5	2.5	Cc1ccnc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
	54764239	68524	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	272	2	1	3	2.7	CC/C=C1\C[C@H]2CNc3c(OC)cccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
	CHEMBL1922537	68524	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	272	2	1	3	2.7	CC/C=C1\C[C@H]2CNc3c(OC)cccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
	11630623	88670	0	None	-1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337499	88670	0	None	-1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365399	88670	0	None	-1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	56649649	67515	0	None	-93	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	480	8	0	5	4.6	COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)CC3)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
	CHEMBL1910140	67515	0	None	-93	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	480	8	0	5	4.6	COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)CC3)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
	86221574	166134	2	None	9	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting methodDisplacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting method	ChEMBL	375	5	2	2	3.4	O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccccc2)CC1	10.1039/C8MD00204E
	CHEMBL4282117	166134	2	None	9	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting methodDisplacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting method	ChEMBL	375	5	2	2	3.4	O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccccc2)CC1	10.1039/C8MD00204E
	162674022	182639	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	305	4	1	4	3.5	N#Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
	CHEMBL4796102	182639	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	305	4	1	4	3.5	N#Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
	44299663	162576	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	306	3	2	3	3.9	CN(C)c1ccc(NC(=O)Nc2ccnc3ccccc23)cc1	10.1016/s0960-894x(01)00343-2
	CHEMBL417753	162576	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	306	3	2	3	3.9	CN(C)c1ccc(NC(=O)Nc2ccnc3ccccc23)cc1	10.1016/s0960-894x(01)00343-2
	10127939	71898	0	None	-39	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	477	7	0	4	5.3	COc1ccc(N2CCN(c3ccc(C)c(C(F)(F)F)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
	CHEMBL198171	71898	0	None	-39	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	477	7	0	4	5.3	COc1ccc(N2CCN(c3ccc(C)c(C(F)(F)F)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
	49850772	56105	0	None	-501	9	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	397	5	0	5	4.1	Cc1ccc2c(N3CCN(CCc4cccc(-n5cccn5)c4)CC3)cccc2n1	10.1021/jm100714c
	CHEMBL1631545	56105	0	None	-501	9	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	397	5	0	5	4.1	Cc1ccc2c(N3CCN(CCc4cccc(-n5cccn5)c4)CC3)cccc2n1	10.1021/jm100714c
	44298208	193019	0	None	-39	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	429	3	1	5	4.9	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cnc(Oc3cccnc3C)cn1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL53308	193019	0	None	-39	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	429	3	1	5	4.9	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cnc(Oc3cccnc3C)cn1)CC2	10.1016/s0960-894x(00)00364-4
	18931357	204862	0	None	-15	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	578	11	3	8	3.2	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(Cl)cc1	10.1016/S0960-894X(96)00503-3
	CHEMBL88894	204862	0	None	-15	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	578	11	3	8	3.2	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(Cl)cc1	10.1016/S0960-894X(96)00503-3
	153287568	170418	0	None	15	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	217	0	1	2	2.5	Cc1cc(C)c2c(c1)OC[C@@]1(C)NCC[C@@H]21	10.1021/acsmedchemlett.9b00225
	CHEMBL4456195	170418	0	None	15	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	217	0	1	2	2.5	Cc1cc(C)c2c(c1)OC[C@@]1(C)NCC[C@@H]21	10.1021/acsmedchemlett.9b00225
	12017598	167554	0	None	-15	3	Human	7.1	pKi	=	7.1	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	429	4	1	5	4.4	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ccccn3)nn1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL432879	167554	0	None	-15	3	Human	7.1	pKi	=	7.1	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	429	4	1	5	4.4	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ccccn3)nn1)CC2	10.1016/s0960-894x(00)00365-6
	21533446	69812	0	None	-213	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	379	6	1	3	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	CHEMBL1940403	69812	0	None	-213	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	379	6	1	3	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	117209964	185552	1	None	-10	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4871980	185552	1	None	-10	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	10194524	72207	0	None	-63	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	415	7	0	5	3.0	COc1ccc(N2CCN(c3cccc(F)c3)C2=O)cc1OCCN1CCOCC1	10.1016/j.bmcl.2005.08.004
	CHEMBL199177	72207	0	None	-63	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	415	7	0	5	3.0	COc1ccc(N2CCN(c3cccc(F)c3)C2=O)cc1OCCN1CCOCC1	10.1016/j.bmcl.2005.08.004
	49850567	56175	0	None	-3981	9	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	452	6	1	6	4.0	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cnccn5)c4)CC3)cccc2n1	10.1021/jm100714c
	CHEMBL1632217	56175	0	None	-3981	9	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	452	6	1	6	4.0	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cnccn5)c4)CC3)cccc2n1	10.1021/jm100714c
	44298142	101275	0	None	-199	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	380	3	1	4	4.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3ccc(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL299726	101275	0	None	-199	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	380	3	1	4	4.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3ccc(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
	153287574	174675	0	None	-10	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	266	2	1	2	4.0	CC[C@H]1c2ccccc2N(c2ccccc2)C[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	CHEMBL4572167	174675	0	None	-10	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	266	2	1	2	4.0	CC[C@H]1c2ccccc2N(c2ccccc2)C[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	10368126	86292	0	None	-25	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	449	7	0	6	4.2	COc1ccc2c(c1)c1c(n2C)CN(c2ccc(OC)c(OCCN3CCCCC3)c2)C1=O	10.1016/j.bmcl.2006.10.034
	CHEMBL231833	86292	0	None	-25	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	449	7	0	6	4.2	COc1ccc2c(c1)c1c(n2C)CN(c2ccc(OC)c(OCCN3CCCCC3)c2)C1=O	10.1016/j.bmcl.2006.10.034
	25164129	160613	0	None	-1479	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	ChEMBL	447	12	1	5	4.1	CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4088036	160613	0	None	-1479	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	ChEMBL	447	12	1	5	4.1	CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4117406	160613	0	None	-1479	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	ChEMBL	447	12	1	5	4.1	CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	25056080	65359	0	None	-407	2	Human	5.1	pKi	=	5.1	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	342	3	1	3	2.3	CCN/C(=N\S(=O)(=O)c1cccc(Cl)c1)N1CC(C)(C)C=N1	10.1021/jm200466r
	CHEMBL1834345	65359	0	None	-407	2	Human	5.1	pKi	=	5.1	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	342	3	1	3	2.3	CCN/C(=N\S(=O)(=O)c1cccc(Cl)c1)N1CC(C)(C)C=N1	10.1021/jm200466r
	24826788	90667	0	None	7	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	236	0	1	2	1.3	O=C1c2c(Cl)cccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397893	90667	0	None	7	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	236	0	1	2	1.3	O=C1c2c(Cl)cccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	71657836	120185	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(Br)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402673	120185	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(Br)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547134	120185	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(Br)c2)C1	10.1016/j.bmc.2015.01.060
	135453290	133083	23	None	-2	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL371300	133083	23	None	-2	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	134551	355	25	None	-6	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
	271	355	25	None	-6	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
	885	355	25	None	-6	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
	CHEMBL1403281	355	25	None	-6	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
	30241	41799	14	None	-8	3	Human	8.1	pKi	=	8.1	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	204	3	2	2	2.2	COc1ccc2[nH]cc(C(C)CN)c2c1	10.1021/jm980318q
	CHEMBL149564	41799	14	None	-8	3	Human	8.1	pKi	=	8.1	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	204	3	2	2	2.2	COc1ccc2[nH]cc(C(C)CN)c2c1	10.1021/jm980318q
	11492162	71709	2	None	10	4	Human	8.1	pKi	=	8.1	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	206	3	1	1	2.4	CN(C)CCc1c[nH]c2cccc(F)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL197646	71709	2	None	10	4	Human	8.1	pKi	=	8.1	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	206	3	1	1	2.4	CN(C)CCc1c[nH]c2cccc(F)c12	10.1016/j.bmcl.2005.06.104
	11615459	197568	0	None	10	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1cccc2c1C(=O)NC1CNCCN21	10.1016/j.bmcl.2009.12.014
	CHEMBL590078	197568	0	None	10	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1cccc2c1C(=O)NC1CNCCN21	10.1016/j.bmcl.2009.12.014
	135414348	72464	2	None	-4	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	205	2	2	4	1.4	Cc1c(O)ccc2cnn(C[C@H](C)N)c12	10.1021/jm050663x
	CHEMBL200104	72464	2	None	-4	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	205	2	2	4	1.4	Cc1c(O)ccc2cnn(C[C@H](C)N)c12	10.1021/jm050663x
	CHEMBL5082177	213020	0	None	5	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCCN(CCC)Cc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	2726	906	64	None	-19	72	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	621	906	64	None	-19	72	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	83	906	64	None	-19	72	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	CHEMBL71	906	64	None	-19	72	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	DB00477	906	64	None	-19	72	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	122178698	120851	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	369	5	0	5	3.9	CCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL3581244	120851	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	369	5	0	5	3.9	CCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	10827035	120193	0	None	-13	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(Cl)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402666	120193	0	None	-13	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(Cl)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547152	120193	0	None	-13	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(Cl)cc2)C1	10.1016/j.bmc.2015.01.060
	118729281	120172	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	265	2	0	1	4.0	Cc1ccccc1[C@H]1C[C@H](N(C)C)Cc2ccccc21	10.1016/j.bmc.2015.01.060
	CHEMBL3402686	120172	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	265	2	0	1	4.0	Cc1ccccc1[C@H]1C[C@H](N(C)C)Cc2ccccc21	10.1016/j.bmc.2015.01.060
	CHEMBL3547018	120172	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	265	2	0	1	4.0	Cc1ccccc1[C@H]1C[C@H](N(C)C)Cc2ccccc21	10.1016/j.bmc.2015.01.060
	44409316	74671	0	None	-102	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	267	0	1	3	1.6	C[C@@H]1CNC[C@H]2Cc3ccc(Br)nc3N12	10.1016/j.bmcl.2005.11.083
	CHEMBL203393	74671	0	None	-102	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	267	0	1	3	1.6	C[C@@H]1CNC[C@H]2Cc3ccc(Br)nc3N12	10.1016/j.bmcl.2005.11.083
	145965940	163646	0	None	2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	273	2	2	4	2.8	C[C@@H]1SC(c2cc3ccccc3cc2O)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	CHEMBL4210787	163646	0	None	2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	273	2	2	4	2.8	C[C@@H]1SC(c2cc3ccccc3cc2O)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	100	3745	52	None	-11	55	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	2637	3745	52	None	-11	55	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	5452	3745	52	None	-11	55	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	CHEMBL479	3745	52	None	-11	55	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	DB00679	3745	52	None	-11	55	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	168277348	189705	0	None	-1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	425	8	0	5	5.4	CCCCC(C)Oc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	CHEMBL5175973	189705	0	None	-1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	425	8	0	5	5.4	CCCCC(C)Oc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	155558726	174236	0	None	-19	4	Human	5.1	pKi	=	5.1	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	835	11	0	13	6.7	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CC[C@H]3O[C@H](Cn4cc(nn4)COC[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12)[C@@H]1OC(C)(C)O[C@@H]1[C@H]3OCCC(C)C	10.1016/j.ejmech.2019.04.064
	CHEMBL4562303	174236	0	None	-19	4	Human	5.1	pKi	=	5.1	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	835	11	0	13	6.7	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CC[C@H]3O[C@H](Cn4cc(nn4)COC[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12)[C@@H]1OC(C)(C)O[C@@H]1[C@H]3OCCC(C)C	10.1016/j.ejmech.2019.04.064
	3042	1386	31	None	-39	15	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	355	1386	31	None	-39	15	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	868	1386	31	None	-39	15	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	CHEMBL1123	1386	31	None	-39	15	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	DB00804	1386	31	None	-39	15	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	122483275	137582	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3764133	137582	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765875	137582	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	11949706	198372	0	None	-11	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]DOI from human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from human 5HT2B receptor expressed in CHO cells	ChEMBL	359	4	1	4	3.4	C[C@@H]1CNCCN1c1ccc2c(n1)[C@@H](OCc1cc(F)ccc1F)CC2	10.1016/j.bmcl.2009.10.112
	CHEMBL595645	198372	0	None	-11	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]DOI from human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from human 5HT2B receptor expressed in CHO cells	ChEMBL	359	4	1	4	3.4	C[C@@H]1CNCCN1c1ccc2c(n1)[C@@H](OCc1cc(F)ccc1F)CC2	10.1016/j.bmcl.2009.10.112
	3037629	183989	13	None	1	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	396	5	1	5	3.6	C=C[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	CHEMBL4848517	183989	13	None	1	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	396	5	1	5	3.6	C=C[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	130442572	171342	0	None	-17	24	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4469848	171342	0	None	-17	24	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	5591	156989	84	None	1	2	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	nan
	CHEMBL408	156989	84	None	1	2	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	nan
	21044398	140553	0	None	-21	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	233	1	2	4	0.9	C[C@H](O)c1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
	CHEMBL382618	140553	0	None	-21	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	233	1	2	4	0.9	C[C@H](O)c1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
	46945446	17580	0	None	-5	2	Human	5.1	pKi	=	5.1	Binding	Inhibition of 5-HT2B receptorInhibition of 5-HT2B receptor	ChEMBL	408	9	0	5	4.6	CCCCOc1ccc(-c2nn3c(C)cc(C)nc3c2CC(=O)N(CC)CC)cc1	10.1016/j.bmcl.2010.07.135
	CHEMBL1258723	17580	0	None	-5	2	Human	5.1	pKi	=	5.1	Binding	Inhibition of 5-HT2B receptorInhibition of 5-HT2B receptor	ChEMBL	408	9	0	5	4.6	CCCCOc1ccc(-c2nn3c(C)cc(C)nc3c2CC(=O)N(CC)CC)cc1	10.1016/j.bmcl.2010.07.135
	136118657	92624	0	None	12	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3c(Br)cccc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2442269	92624	0	None	12	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3c(Br)cccc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
	44451393	156131	1	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	211	1	1	2	2.0	COc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
	CHEMBL406957	156131	1	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	211	1	1	2	2.0	COc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
	11437171	83077	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	234	1	1	3	1.5	CSc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	CHEMBL220207	83077	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	234	1	1	3	1.5	CSc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	155558968	174246	0	None	-1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	432	3	2	5	3.2	Cc1cccc(C)c1N1C(=O)[C@H](CC2CNc3ccccc32)NC2(CCN(C)CC2)C1=O	10.1016/j.ejmech.2018.12.048
	CHEMBL4562437	174246	0	None	-1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	432	3	2	5	3.2	Cc1cccc(C)c1N1C(=O)[C@H](CC2CNc3ccccc32)NC2(CCN(C)CC2)C1=O	10.1016/j.ejmech.2018.12.048
	44572802	12338	2	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL1186019	12338	2	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL445747	12338	2	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	136016509 136118731	10859	0	None	2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2ccc(Br)cc12	10.1016/j.bmc.2013.09.011
	CHEMBL1173331	10859	0	None	2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2ccc(Br)cc12	10.1016/j.bmc.2013.09.011
	3168	9172	84	None	-107	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
	CHEMBL1108	9172	84	None	-107	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
	71450550	83393	0	None	-1	16	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
	CHEMBL2205836	83393	0	None	-1	16	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
	4543	169982	36	None	-3	29	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2ccccc21	nan
	CHEMBL1201156	169982	36	None	-3	29	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2ccccc21	nan
	CHEMBL445	169982	36	None	-3	29	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2ccccc21	nan
	11300712	141154	0	None	2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	252	1	1	3	1.4	COc1c(Cl)ccc2c1C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL385577	141154	0	None	2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	252	1	1	3	1.4	COc1c(Cl)ccc2c1C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	59757162	105823	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)-c1ccccc1C2O	10.1016/j.bmc.2013.10.010
	CHEMBL3092761	105823	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)-c1ccccc1C2O	10.1016/j.bmc.2013.10.010
	CHEMBL3139074	105823	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)-c1ccccc1C2O	10.1016/j.bmc.2013.10.010
	1548953	205945	24	None	-4	17	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
	CHEMBL954	205945	24	None	-4	17	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
	5870	31445	85	None	-	1	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	270	0	1	2	3.8	C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CCC2=O	nan
	CHEMBL1405	31445	85	None	-	1	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	270	0	1	2	3.8	C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CCC2=O	nan
	6452095	40462	17	None	-9	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	174	2	2	1	2.2	CC(CN)c1c[nH]c2ccccc12	10.1021/jm980318q
	CHEMBL148463	40462	17	None	-9	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	174	2	2	1	2.2	CC(CN)c1c[nH]c2ccccc12	10.1021/jm980318q
	11493484	88641	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337106	88641	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365079	88641	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	21509921	103979	0	None	-8	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
	CHEMBL3104091	103979	0	None	-8	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
	44554395	18536	0	None	-54	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	406	3	1	6	3.0	Cn1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CCNCC3)ccc21	10.1021/jm1007825
	CHEMBL1277565	18536	0	None	-54	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	406	3	1	6	3.0	Cn1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CCNCC3)ccc21	10.1021/jm1007825
	21509921	103979	0	None	-8	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
	CHEMBL3104091	103979	0	None	-8	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
	155565189	174992	0	None	-6	4	Human	6.1	pKi	=	6.1	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	634	7	0	9	6.2	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CCCCCCOCc3cn(nn3)C[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12	10.1016/j.ejmech.2019.04.064
	CHEMBL4579120	174992	0	None	-6	4	Human	6.1	pKi	=	6.1	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	634	7	0	9	6.2	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CCCCCCOCc3cn(nn3)C[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12	10.1016/j.ejmech.2019.04.064
	18735309	203722	0	None	-3	3	Human	7.1	pKi	=	7.1	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	262	2	1	2	2.6	C[C@H](N)CN1CCc2cc(F)c(C(F)(F)F)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL80246	203722	0	None	-3	3	Human	7.1	pKi	=	7.1	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	262	2	1	2	2.6	C[C@H](N)CN1CCc2cc(F)c(C(F)(F)F)cc21	10.1016/j.bmcl.2003.05.001
	53381002	65134	0	None	15	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation counting	ChEMBL	240	2	2	4	2.2	COc1cccc2[nH]cc(-c3ccnc(N)n3)c12	10.1016/j.bmc.2011.08.033
	CHEMBL1829959	65134	0	None	15	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation counting	ChEMBL	240	2	2	4	2.2	COc1cccc2[nH]cc(-c3ccnc(N)n3)c12	10.1016/j.bmc.2011.08.033
	56649650	67516	0	None	-100	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	466	8	0	5	4.2	COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)C3)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
	CHEMBL1910141	67516	0	None	-100	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	466	8	0	5	4.2	COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)C3)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
	71062530	159545	0	None	-3	2	Mouse	5.1	pKi	=	5.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	353	5	0	5	1.8	O=C(CN1CCO[C@@H](COc2cccnc2)C1)N1CCc2ccccc21	nan
	CHEMBL4108620	159545	0	None	-3	2	Mouse	5.1	pKi	=	5.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	353	5	0	5	1.8	O=C(CN1CCO[C@@H](COc2cccnc2)C1)N1CCc2ccccc21	nan
	44407327	140716	0	None	-5	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	345	6	1	4	4.4	COc1ccccc1CN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL383042	140716	0	None	-5	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	345	6	1	4	4.4	COc1ccccc1CN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	136118617	75896	0	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2058416	75896	0	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C	10.1016/j.bmc.2013.09.011
	44315993	172308	0	None	-15	3	Human	7.1	pKi	=	7.1	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	222	3	1	3	2.1	CSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	CHEMBL451543	172308	0	None	-15	3	Human	7.1	pKi	=	7.1	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	222	3	1	3	2.1	CSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	44572810	12546	2	None	2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
	CHEMBL1187196	12546	2	None	2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
	CHEMBL493130	12546	2	None	2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
	11346775	83068	0	None	-4	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	252	1	1	3	1.4	COc1cc(Cl)c2c(c1)[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL220157	83068	0	None	-4	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	252	1	1	3	1.4	COc1cc(Cl)c2c(c1)[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	132060776	161852	0	None	-3	16	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	419	4	0	4	4.4	O=C(OCc1ccccc1)N1CCc2ccc(N3CCN(C4CCCC4)CC3)cc2C1	10.1016/j.ejmech.2018.02.024
	CHEMBL4165863	161852	0	None	-3	16	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	419	4	0	4	4.4	O=C(OCc1ccccc1)N1CCc2ccc(N3CCN(C4CCCC4)CC3)cc2C1	10.1016/j.ejmech.2018.02.024
	136118658	75901	0	None	2	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3cccc(Br)c23)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2058426	75901	0	None	2	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3cccc(Br)c23)N1C	10.1016/j.bmc.2013.09.011
	13091356	113039	0	None	-218	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	389	6	1	3	4.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCOc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
	CHEMBL3321789	113039	0	None	-218	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	389	6	1	3	4.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCOc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
	118717223	120071	0	None	-7	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	321	1	2	2	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CCOCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343671	120071	0	None	-7	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	321	1	2	2	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CCOCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3545813	120071	0	None	-7	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	321	1	2	2	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CCOCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	46914485	15258	0	None	83	3	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	336	5	0	4	3.8	COc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
	CHEMBL1214961	15258	0	None	83	3	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	336	5	0	4	3.8	COc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
	44397731	66882	0	None	-23	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	213	0	1	3	1.3	C[C@@H]1CNC[C@H]2Cc3ccc(C#N)cc3N12	10.1016/j.bmcl.2005.05.074
	CHEMBL187888	66882	0	None	-23	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	213	0	1	3	1.3	C[C@@H]1CNC[C@H]2Cc3ccc(C#N)cc3N12	10.1016/j.bmcl.2005.05.074
	6319	23272	90	None	-	1	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	4	2	2	5.2	c1ccc(Nc2ccc(Nc3ccccc3)cc2)cc1	nan
	CHEMBL1333512	23272	90	None	-	1	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	4	2	2	5.2	c1ccc(Nc2ccc(Nc3ccccc3)cc2)cc1	nan
	44451369	95887	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	187	0	1	2	2.1	c1cc2c3c(ccc2o1)CCNCC3	10.1016/j.bmc.2007.12.009
	CHEMBL261489	95887	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	187	0	1	2	2.1	c1cc2c3c(ccc2o1)CCNCC3	10.1016/j.bmc.2007.12.009
	135753056	190581	1	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5-HT2B receptor (unknown origin) assessed as displacement of radioligand at 10 uM by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) assessed as displacement of radioligand at 10 uM by radioligand binding assay	ChEMBL	337	4	2	5	2.4	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2cccc(C)c2)n1	10.1021/acs.jmedchem.1c01759
	CHEMBL5188949	190581	1	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5-HT2B receptor (unknown origin) assessed as displacement of radioligand at 10 uM by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) assessed as displacement of radioligand at 10 uM by radioligand binding assay	ChEMBL	337	4	2	5	2.4	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2cccc(C)c2)n1	10.1021/acs.jmedchem.1c01759
	16062145	97209	0	None	-223	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	269	2	1	3	2.8	Fc1ccc(-c2nc(C3CC3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL271111	97209	0	None	-223	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	269	2	1	3	2.8	Fc1ccc(-c2nc(C3CC3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
	11716185	88635	0	None	-20	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	250	1	2	2	1.7	CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337497	88635	0	None	-20	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	250	1	2	2	1.7	CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2364998	88635	0	None	-20	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	250	1	2	2	1.7	CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	10028436	3476	3	None	-45	12	Human	7.0	pKi	=	7.0	Binding	Compound was tested for its binding affinity for human cloned 5-hydroxytryptamine 2B receptor in HEK 293 using [3H]ketanserin as a radioligandCompound was tested for its binding affinity for human cloned 5-hydroxytryptamine 2B receptor in HEK 293 using [3H]ketanserin as a radioligand	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/s0960-894x(02)00690-x
	3237	3476	3	None	-45	12	Human	7.0	pKi	=	7.0	Binding	Compound was tested for its binding affinity for human cloned 5-hydroxytryptamine 2B receptor in HEK 293 using [3H]ketanserin as a radioligandCompound was tested for its binding affinity for human cloned 5-hydroxytryptamine 2B receptor in HEK 293 using [3H]ketanserin as a radioligand	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/s0960-894x(02)00690-x
	CHEMBL95104	3476	3	None	-45	12	Human	7.0	pKi	=	7.0	Binding	Compound was tested for its binding affinity for human cloned 5-hydroxytryptamine 2B receptor in HEK 293 using [3H]ketanserin as a radioligandCompound was tested for its binding affinity for human cloned 5-hydroxytryptamine 2B receptor in HEK 293 using [3H]ketanserin as a radioligand	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/s0960-894x(02)00690-x
	25209705	180478	23	None	-144	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	510	7	2	8	3.3	COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCNCC5)cc4=O)c3C)cc2)cn1	10.1021/jm800962k
	CHEMBL475965	180478	23	None	-144	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	510	7	2	8	3.3	COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCNCC5)cc4=O)c3C)cc2)cn1	10.1021/jm800962k
	168294400	191882	0	None	1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	423	5	0	5	5.2	COc1cc2c(cc1OC)-c1c(OC)c(OC3CCCCC3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL5208882	191882	0	None	1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	423	5	0	5	5.2	COc1cc2c(cc1OC)-c1c(OC)c(OC3CCCCC3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	118055296	177377	0	None	-58	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	264	2	1	2	2.7	c1ccc(Cc2ccc3c4c2CCN4CCNC3)cc1	10.1016/j.bmcl.2019.126929
	CHEMBL4645736	177377	0	None	-58	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	264	2	1	2	2.7	c1ccc(Cc2ccc3c4c2CCN4CCNC3)cc1	10.1016/j.bmcl.2019.126929
	122483281	137580	0	None	-18	8	Human	7.0	pKi	=	7.0	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3763779	137580	0	None	-18	8	Human	7.0	pKi	=	7.0	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765873	137580	0	None	-18	8	Human	7.0	pKi	=	7.0	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	136118649	75969	0	None	2	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.0	C/N=C1\NC(=O)/C(=C/c2c[nH]c3ccc(Br)cc23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2058704	75969	0	None	2	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.0	C/N=C1\NC(=O)/C(=C/c2c[nH]c3ccc(Br)cc23)N1	10.1016/j.bmc.2013.09.011
	11819486	120636	0	None	-4	4	Human	7.0	pKi	=	7.0	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	172	1	2	1	2.0	N[C@H]1C[C@@H]1c1c[nH]c2ccccc12	10.1021/jm980318q
	CHEMBL357702	120636	0	None	-4	4	Human	7.0	pKi	=	7.0	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	172	1	2	1	2.0	N[C@H]1C[C@@H]1c1c[nH]c2ccccc12	10.1021/jm980318q
	58911668	90679	0	None	-3	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	1	1	2	1.2	CCc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397905	90679	0	None	-3	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	1	1	2	1.2	CCc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	162652711	179799	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	409	6	3	7	2.6	CC(C)[C@@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CF)C[C@H]12)C1CC1	10.1016/j.bmcl.2020.127599
	CHEMBL4751718	179799	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	409	6	3	7	2.6	CC(C)[C@@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CF)C[C@H]12)C1CC1	10.1016/j.bmcl.2020.127599
	71452341	83283	4	None	-3	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by scintillation counting analysis	ChEMBL	376	6	0	3	5.3	Cc1c(C(=O)N(CCCN2CCCCC2)c2ccccc2)oc2ccccc12	10.1016/j.bmc.2012.09.044
	CHEMBL2205361	83283	4	None	-3	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by scintillation counting analysis	ChEMBL	376	6	0	3	5.3	Cc1c(C(=O)N(CCCN2CCCCC2)c2ccccc2)oc2ccccc12	10.1016/j.bmc.2012.09.044
	11848625	5715	0	None	2	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	451	8	1	7	4.9	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)cc(OC2CCOCC2)c1	10.1016/j.bmcl.2009.09.024
	CHEMBL1078745	5715	0	None	2	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	451	8	1	7	4.9	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)cc(OC2CCOCC2)c1	10.1016/j.bmcl.2009.09.024
	136118614	92632	0	None	13	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3ccc(Br)cc23)C1=O	10.1016/j.bmc.2013.09.011
	CHEMBL2442276	92632	0	None	13	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3ccc(Br)cc23)C1=O	10.1016/j.bmc.2013.09.011
	10106214	2073	1	None	-46	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	251	2	0	1	3.7	CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C	10.1016/j.bmc.2015.01.060
	1207	2073	1	None	-46	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	251	2	0	1	3.7	CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C	10.1016/j.bmc.2015.01.060
	1209	2073	1	None	-46	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	251	2	0	1	3.7	CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C	10.1016/j.bmc.2015.01.060
	CHEMBL127307	2073	1	None	-46	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	251	2	0	1	3.7	CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C	10.1016/j.bmc.2015.01.060
	6604117	187264	6	None	1	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
	CHEMBL2062340	187264	6	None	1	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
	CHEMBL49623	187264	6	None	1	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
	49864027	15243	0	None	25	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	400	8	0	4	4.8	FC(F)CCOc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
	CHEMBL1214891	15243	0	None	25	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	400	8	0	4	4.8	FC(F)CCOc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
	168279369	190539	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	397	6	0	5	4.6	CCC(C)Oc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	CHEMBL5188171	190539	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	397	6	0	5	4.6	CCC(C)Oc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	122186880	122465	0	None	4	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	415	3	0	5	4.8	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	CHEMBL3608450	122465	0	None	4	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	415	3	0	5	4.8	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	44554227	18563	0	None	-33	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	434	4	1	6	4.0	CC(C)n1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CCNCC3)ccc21	10.1021/jm1007825
	CHEMBL1277837	18563	0	None	-33	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	434	4	1	6	4.0	CC(C)n1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CCNCC3)ccc21	10.1021/jm1007825
	20824949	66860	0	None	-1	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	245	1	2	3	1.4	CC(=O)Nc1ccc2c(c1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
	CHEMBL187787	66860	0	None	-1	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	245	1	2	3	1.4	CC(=O)Nc1ccc2c(c1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
	667590	67452	12	None	-	1	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	3	0	1	4.4	O=C(c1ccccc1Cl)N1CCC(Cc2ccccc2)CC1	nan
	CHEMBL1909048	67452	12	None	-	1	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	3	0	1	4.4	O=C(c1ccccc1Cl)N1CCC(Cc2ccccc2)CC1	nan
	44582676	189187	0	None	-7	17	Human	6.0	pKi	=	6.0	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	403	9	0	4	4.3	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL516088	189187	0	None	-7	17	Human	6.0	pKi	=	6.0	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	403	9	0	4	4.3	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	135511529 135555540	10886	0	None	5	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	240	1	3	2	1.5	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2ccccc12	10.1016/j.bmc.2013.09.011
	CHEMBL1173525	10886	0	None	5	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	240	1	3	2	1.5	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2ccccc12	10.1016/j.bmc.2013.09.011
	136118661	75904	0	None	6	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3c(Br)cccc23)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2058429	75904	0	None	6	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3c(Br)cccc23)N1C	10.1016/j.bmc.2013.09.011
	44112	120777	41	None	-11	7	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	nan
	CHEMBL357995	120777	41	None	-11	7	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	nan
	124247485	163517	7	None	1	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4209274	163517	7	None	1	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	155563428	174714	0	None	-1	5	Human	7.0	pKi	=	7.0	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	475	7	3	9	2.7	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CCC4)C4CCC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	CHEMBL4572905	174714	0	None	-1	5	Human	7.0	pKi	=	7.0	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	475	7	3	9	2.7	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CCC4)C4CCC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	44581974	175131	0	None	-1	9	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	513	6	2	6	4.6	Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
	CHEMBL458220	175131	0	None	-1	9	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	513	6	2	6	4.6	Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
	25123013	198774	0	None	-27	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	378	3	2	5	2.7	NC1CN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
	CHEMBL598443	198774	0	None	-27	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	378	3	2	5	2.7	NC1CN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
	10383646	18575	0	None	-512	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	356	3	1	5	2.1	CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4ccccc4)c3c2)CC1	10.1021/jm1007825
	CHEMBL1277917	18575	0	None	-512	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	356	3	1	5	2.1	CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4ccccc4)c3c2)CC1	10.1021/jm1007825
	71450247	82563	0	None	-19	9	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	368	5	0	3	5.5	CCCN1CCC(COc2nc3c(Cl)cccc3c3ccccc23)CC1	10.1021/jm300943r
	CHEMBL2181188	82563	0	None	-19	9	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	368	5	0	3	5.5	CCCN1CCC(COc2nc3c(Cl)cccc3c3ccccc23)CC1	10.1021/jm300943r
	44404905	72035	0	None	3	3	Human	7.0	pKi	=	7.0	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	218	4	2	2	2.4	CN(C)CCCc1c[nH]c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL198617	72035	0	None	3	3	Human	7.0	pKi	=	7.0	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	218	4	2	2	2.4	CN(C)CCCc1c[nH]c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
	17683252	67454	3	None	-	1	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	347	3	0	1	4.8	O=C(c1ccccc1C(F)(F)F)N1CCC(Cc2ccccc2)CC1	nan
	CHEMBL1909051	67454	3	None	-	1	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	347	3	0	1	4.8	O=C(c1ccccc1C(F)(F)F)N1CCC(Cc2ccccc2)CC1	nan
	142601328	184420	0	None	-63	5	Human	6.0	pKi	=	6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4854605	184420	0	None	-63	5	Human	6.0	pKi	=	6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	142601341	184790	0	None	-3	3	Human	6.0	pKi	=	6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4860503	184790	0	None	-3	3	Human	6.0	pKi	=	6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	56649648	67513	0	None	-301	8	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	474	8	0	5	3.0	COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52CF)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
	CHEMBL1910139	67513	0	None	-301	8	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	474	8	0	5	3.0	COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52CF)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
	136118616	75895	0	None	3	5	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3cccc(Br)c23)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2058415	75895	0	None	3	5	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3cccc(Br)c23)N1C	10.1016/j.bmc.2013.09.011
	136118646	75966	0	None	2	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	335	1	2	3	3.1	CSC1=NC(=O)/C(=C/c2c[nH]c3c(Br)cccc23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2058701	75966	0	None	2	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	335	1	2	3	3.1	CSC1=NC(=O)/C(=C/c2c[nH]c3c(Br)cccc23)N1	10.1016/j.bmc.2013.09.011
	3007	155144	25	None	-1	6	Rat	8.3	pKd	=	8.3	Binding	Affinity against serotonergic receptor in the isolated rat stomach fundusAffinity against serotonergic receptor in the isolated rat stomach fundus	Drug Central	135	2	1	1	1.6	CC(N)Cc1ccccc1	None
	CHEMBL405	155144	25	None	-1	6	Rat	8.3	pKd	=	8.3	Binding	Affinity against serotonergic receptor in the isolated rat stomach fundusAffinity against serotonergic receptor in the isolated rat stomach fundus	Drug Central	135	2	1	1	1.6	CC(N)Cc1ccccc1	None
	10615	566	26	None	501	4	Human	11.6	pKd	=	11.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	409	3	0	6	4.4	CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1	31951127
	46200932	566	26	None	501	4	Human	11.6	pKd	=	11.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	409	3	0	6	4.4	CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1	31951127
	CHEMBL4297183	566	26	None	501	4	Human	11.6	pKd	=	11.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	409	3	0	6	4.4	CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1	31951127
	DB14823	566	26	None	501	4	Human	11.6	pKd	=	11.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	409	3	0	6	4.4	CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1	31951127
	136	3240	28	None	-12	16	Human	8.4	pKd	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
	223	3240	28	None	-12	16	Human	8.4	pKd	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
	643606	3240	28	None	-12	16	Human	8.4	pKd	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
	CHEMBL10347	3240	28	None	-12	16	Human	8.4	pKd	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
	134	2478	19	3H- LSD	-2	67	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	134	2478	19	3H-LSD	-2	67	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2478	19	3H- LSD	-2	67	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2478	19	3H-LSD	-2	67	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2478	19	3H- LSD	-2	67	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2478	19	3H-LSD	-2	67	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2478	19	3H- LSD	-2	67	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2478	19	3H-LSD	-2	67	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2478	19	3H- LSD	-2	67	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2478	19	3H-LSD	-2	67	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	188	3339	73	3H-5HT	-1	6	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	None
	196968	3339	73	3H-5HT	-1	6	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	None
	CHEMBL473186	3339	73	3H-5HT	-1	6	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	None
	242	467	117	3H-LSD	-1	51	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	242	467	117	[3H]-LSD	-1	51	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	467	117	3H-LSD	-1	51	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	467	117	[3H]-LSD	-1	51	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	467	117	3H-LSD	-1	51	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	467	117	[3H]-LSD	-1	51	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	467	117	3H-LSD	-1	51	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	467	117	[3H]-LSD	-1	51	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	467	117	3H-LSD	-1	51	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	467	117	[3H]-LSD	-1	51	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	134	2478	19	3H-5HT	-2	67	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2478	19	3H-5HT	-2	67	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2478	19	3H-5HT	-2	67	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2478	19	3H-5HT	-2	67	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2478	19	3H-5HT	-2	67	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	5074	3280	75	3H-RAUWOLSCINE	-3	29	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3280	75	3H-RAUWOLSCINE	-3	29	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3280	75	3H-RAUWOLSCINE	-3	29	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3280	75	3H-RAUWOLSCINE	-3	29	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	None	214281	0	3H-5HT	-2	7	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	339	4	3	3	1.9	CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
	None	214281	0	3H-5HT	-2	7	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	339	4	3	3	1.9	CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
	107	141	116	3H-5HT	-4	30	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	116	3H-5HT	-4	30	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	116	3H-5HT	-4	30	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	None	214630	0	3H-MESULERGINE	5	4	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	342	4	3	4	2.5	CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N.C(=CC(=O)O)C(=O)O	None
	4106	2466	16	3H-RAUWOLSCINE	-3	33	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2466	16	3H-RAUWOLSCINE	-3	33	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2466	16	3H-RAUWOLSCINE	-3	33	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2466	16	3H-RAUWOLSCINE	-3	33	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	134	2478	19	3H-RAUWOLSCINE	-2	67	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2478	19	3H-RAUWOLSCINE	-2	67	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2478	19	3H-RAUWOLSCINE	-2	67	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2478	19	3H-RAUWOLSCINE	-2	67	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2478	19	3H-RAUWOLSCINE	-2	67	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	133	2460	48	3H-MESULERGINE	-2	42	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2460	48	3H-MESULERGINE	-2	42	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2460	48	3H-MESULERGINE	-2	42	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2460	48	3H-MESULERGINE	-2	42	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2460	48	3H-MESULERGINE	-2	42	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	133	2460	48	3H-5HT	-2	42	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2460	48	3H-5HT	-2	42	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2460	48	3H-5HT	-2	42	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2460	48	3H-5HT	-2	42	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2460	48	3H-5HT	-2	42	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	6437377	214175	0	3H-RAUWOLSCINE	5	4	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	500	6	3	7	3.2	CC(C)N1C=C2CC3C(CC(CN3C)C(=O)OC(C)C(C)O)C4=C2C1=CC=C4.C(=CC(=O)O)C(=O)O	None
	5	139	66	3H-5HT	-13	54	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-5HT	-13	54	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-5HT	-13	54	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-5HT	-13	54	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	2470	3596	46	3H-KETANSERIN	-23	59	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3596	46	3H-KETANSERIN	-23	59	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3596	46	3H-KETANSERIN	-23	59	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3596	46	3H-KETANSERIN	-23	59	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3596	46	3H-KETANSERIN	-23	59	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	None	214281	0	Functional	-2	7	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	339	4	3	3	1.9	CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
	1342	36	42	3H-RAUWOLSCINE	2	18	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3	36	42	3H-RAUWOLSCINE	2	18	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	CHEMBL277120	36	42	3H-RAUWOLSCINE	2	18	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	None	214630	0	Functional	5	4	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	342	4	3	4	2.5	CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N.C(=CC(=O)O)C(=O)O	None
	1621	2396	16	3H-5HT	-19	44	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2396	16	3H-5HT	-19	44	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2396	16	3H-5HT	-19	44	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2396	16	3H-5HT	-19	44	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2396	16	3H-5HT	-19	44	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5	139	66	Functional	-13	54	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	Functional	-13	54	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	Functional	-13	54	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	Functional	-13	54	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5074	3280	75	3H-5HT	-3	29	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3280	75	3H-5HT	-3	29	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3280	75	3H-5HT	-3	29	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3280	75	3H-5HT	-3	29	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	1588	2294	24	3H-5HT	-8	43	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2294	24	3H-5HT	-8	43	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2294	24	3H-5HT	-8	43	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2294	24	3H-5HT	-8	43	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2294	24	3H-5HT	-8	43	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	188	3339	73	3H-5HT	-1	6	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	None
	196968	3339	73	3H-5HT	-1	6	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	None
	CHEMBL473186	3339	73	3H-5HT	-1	6	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	None
	None	214703	0	Functional	1	27	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
	5	139	66	3H-5HT	-13	54	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-5HT	-13	54	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-5HT	-13	54	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-5HT	-13	54	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	None	214590	0	3H-MESULERGINE	-1	19	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	451	8	2	4	3.2	CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C	None
	103	4089	56	3H-LSD	1	53	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2875	4089	56	3H-LSD	1	53	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5736	4089	56	3H-LSD	1	53	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL285802	4089	56	3H-LSD	1	53	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB09225	4089	56	3H-LSD	1	53	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5074	3280	75	3H-MESULERGINE	-3	29	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3280	75	3H-MESULERGINE	-3	29	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3280	75	3H-MESULERGINE	-3	29	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3280	75	3H-MESULERGINE	-3	29	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	189	3436	31	UNDEFINED	2	17	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	5163	3436	31	UNDEFINED	2	17	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	CHEMBL297784	3436	31	UNDEFINED	2	17	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	11954224	214174	0	3H-5HT	-66	59	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	1588	2294	24	3H-MESULERGINE	-8	43	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2294	24	3H-MESULERGINE	-8	43	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2294	24	3H-MESULERGINE	-8	43	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2294	24	3H-MESULERGINE	-8	43	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2294	24	3H-MESULERGINE	-8	43	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	1588	2294	24	3H-MESULERGINE	-8	43	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2294	24	3H-MESULERGINE	-8	43	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2294	24	3H-MESULERGINE	-8	43	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2294	24	3H-MESULERGINE	-8	43	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2294	24	3H-MESULERGINE	-8	43	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	2435	3533	78	3H-LSD	-2	48	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	60149	3533	78	3H-LSD	-2	48	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	98	3533	78	3H-LSD	-2	48	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	CHEMBL12713	3533	78	3H-LSD	-2	48	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	DB06144	3533	78	3H-LSD	-2	48	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	11957541	1430	38	Functional	-1	15	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	1229	1430	38	Functional	-1	15	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	147	1430	38	Functional	-1	15	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	170617	1430	38	Functional	-1	15	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	CHEMBL6616	1430	38	Functional	-1	15	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	206	2457	10	3H-5HT	-1	24	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2457	10	3H-5HT	-1	24	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2457	10	3H-5HT	-1	24	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	134	2478	19	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2478	19	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2478	19	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2478	19	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2478	19	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	6437377	214175	0	3H-5HT	5	4	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	500	6	3	7	3.2	CC(C)N1C=C2CC3C(CC(CN3C)C(=O)OC(C)C(C)O)C4=C2C1=CC=C4.C(=CC(=O)O)C(=O)O	None
	277	1274	55	3H-5HT	-5	45	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1274	55	3H-5HT	-5	45	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1274	55	3H-5HT	-5	45	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1274	55	3H-5HT	-5	45	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1274	55	3H-5HT	-5	45	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	4106	2466	16	3H-5HT	-3	33	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2466	16	3H-5HT	-3	33	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2466	16	3H-5HT	-3	33	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2466	16	3H-5HT	-3	33	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	135	2496	38	3H-5HT	-3	57	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2496	38	3H-5HT	-3	57	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2496	38	3H-5HT	-3	57	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2496	38	3H-5HT	-3	57	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2496	38	3H-5HT	-3	57	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	134	2478	19	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2478	19	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2478	19	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2478	19	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2478	19	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	6437377	214175	0	3H-5HT	5	4	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	500	6	3	7	3.2	CC(C)N1C=C2CC3C(CC(CN3C)C(=O)OC(C)C(C)O)C4=C2C1=CC=C4.C(=CC(=O)O)C(=O)O	None
	5074	3280	75	3H-5HT	-3	29	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3280	75	3H-5HT	-3	29	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3280	75	3H-5HT	-3	29	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3280	75	3H-5HT	-3	29	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	134	2478	19	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2478	19	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2478	19	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2478	19	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2478	19	3H-5HT	-2	67	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	5074	3280	75	3H-5HT	-3	29	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3280	75	3H-5HT	-3	29	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3280	75	3H-5HT	-3	29	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3280	75	3H-5HT	-3	29	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	133	2460	48	3H-5HT	-2	42	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2460	48	3H-5HT	-2	42	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2460	48	3H-5HT	-2	42	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2460	48	3H-5HT	-2	42	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2460	48	3H-5HT	-2	42	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	11954224	214174	0	3H- LSD	-66	59	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	11954224	214174	0	3H-LSD	-66	59	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	206	2457	10	3H-RAUWOLSCINE	-1	24	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2457	10	3H-RAUWOLSCINE	-1	24	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2457	10	3H-RAUWOLSCINE	-1	24	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	206	2457	10	3H-MESULERGINE	-1	24	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2457	10	3H-MESULERGINE	-1	24	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2457	10	3H-MESULERGINE	-1	24	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	199	389	0	3H-5HT	3	4	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	None
	9821951	389	0	3H-5HT	3	4	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	None
	CHEMBL160293	389	0	3H-5HT	3	4	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	None
	5	139	66	3H-5HT	-29	54	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-5HT	-29	54	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-5HT	-29	54	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-5HT	-29	54	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5	139	66	3H-5HT	-29	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-5HT	-29	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-5HT	-29	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-5HT	-29	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5	139	66	3H-5HT	-29	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-5HT	-29	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-5HT	-29	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-5HT	-29	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	135398737	944	89	3H-5HT	-2	91	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	944	89	3H-5HT	-2	91	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	944	89	3H-5HT	-2	91	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	944	89	3H-5HT	-2	91	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	944	89	3H-5HT	-2	91	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	152	361	18	3H-5HT	-1	18	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	2107	361	18	3H-5HT	-1	18	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	CHEMBL275854	361	18	3H-5HT	-1	18	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	152	361	18	3H-5HT	-1	18	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	2107	361	18	3H-5HT	-1	18	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	CHEMBL275854	361	18	3H-5HT	-1	18	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	7153	97570	74	3H-RAUWOLSCINE	-1	33	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97570	74	3H-RAUWOLSCINE	-1	33	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	199	389	0	3H-5HT	-5	4	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	None
	9821951	389	0	3H-5HT	-5	4	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	None
	CHEMBL160293	389	0	3H-5HT	-5	4	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	None
	11957541	1430	38	3H-KETANSERIN	-13	15	Bovine	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	1229	1430	38	3H-KETANSERIN	-13	15	Bovine	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	147	1430	38	3H-KETANSERIN	-13	15	Bovine	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	170617	1430	38	3H-KETANSERIN	-13	15	Bovine	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	CHEMBL6616	1430	38	3H-KETANSERIN	-13	15	Bovine	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	1614	201960	22	Functional	2	9	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	179	2	1	3	1.3	CC(N)Cc1ccc2c(c1)OCO2	None
	CHEMBL6731	201960	22	Functional	2	9	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	179	2	1	3	1.3	CC(N)Cc1ccc2c(c1)OCO2	None
	24840389	114714	3	3H-MESULERGINE	-741	15	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	415	9	0	4	4.6	CCCN(CCC)C1CCc2cc(CS(=O)(=O)c3ccc(OC)cc3)ccc2C1	None
	CHEMBL334529	114714	3	3H-MESULERGINE	-741	15	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	415	9	0	4	4.6	CCCN(CCC)C1CCc2cc(CS(=O)(=O)c3ccc(OC)cc3)ccc2C1	None
	1809	134	28	3H-KETANSERIN	-109647	36	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	28	3H-KETANSERIN	-109647	36	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	28	3H-KETANSERIN	-109647	36	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	1209	1628	69	3H-5HT	-199	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	203	1628	69	3H-5HT	-199	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	3386	1628	69	3H-5HT	-199	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	CHEMBL41	1628	69	3H-5HT	-199	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	DB00472	1628	69	3H-5HT	-199	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	1357	2450	133	3H-5HT	-3890	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2450	133	3H-5HT	-3890	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2450	133	3H-5HT	-3890	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2450	133	3H-5HT	-3890	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2450	133	3H-5HT	-3890	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2450	133	3H-5HT	-3890	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	107992	2516	47	3H-5HT	-5	9	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	165	2516	47	3H-5HT	-5	9	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	CHEMBL269521	2516	47	3H-5HT	-5	9	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	DB12111	2516	47	3H-5HT	-5	9	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	208	2820	0	3H-5HT	-69	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	4541	2820	0	3H-5HT	-69	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	CHEMBL1494	2820	0	3H-5HT	-69	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	119570	3110	90	3H-LSD	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	119570	3110	90	3H-MESULERGINE	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	2233	3110	90	3H-LSD	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	2233	3110	90	3H-MESULERGINE	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	953	3110	90	3H-LSD	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	953	3110	90	3H-MESULERGINE	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	CHEMBL301265	3110	90	3H-LSD	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	CHEMBL301265	3110	90	3H-MESULERGINE	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	DB00413	3110	90	3H-LSD	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	DB00413	3110	90	3H-MESULERGINE	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	243	3153	85	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
	3052762	3153	85	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
	3502	3153	85	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
	CHEMBL117287	3153	85	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
	DB06480	3153	85	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
	2	3210	19	3H-MESULERGINE	-363	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
	54562	3210	19	3H-MESULERGINE	-363	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
	CHEMBL240773	3210	19	3H-MESULERGINE	-363	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
	128563	3408	28	3H-LSD	-2398	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
	1666	3408	28	3H-LSD	-2398	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
	CHEMBL445332	3408	28	3H-LSD	-2398	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
	DB12327	3408	28	3H-LSD	-2398	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
	2470	3596	46	3H-5HT	-120226	59	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3596	46	3H-5HT	-120226	59	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3596	46	3H-5HT	-120226	59	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3596	46	3H-5HT	-120226	59	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3596	46	3H-5HT	-120226	59	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	2543	3651	66	3H-5HT	-2818	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	2543	3651	66	3H-5HT	-2818	31	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5358	3651	66	3H-5HT	-2818	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5358	3651	66	3H-5HT	-2818	31	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	54	3651	66	3H-5HT	-2818	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	54	3651	66	3H-5HT	-2818	31	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL128	3651	66	3H-5HT	-2818	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL128	3651	66	3H-5HT	-2818	31	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB00669	3651	66	3H-5HT	-2818	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB00669	3651	66	3H-5HT	-2818	31	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	46882133	5731	0	UNDEFINED	-54	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	478	9	2	7	5.1	CCOc1cc(CN2CCC(Nc3nc4cc(NC(=O)C5CCC5)ccc4o3)CC2)ccc1OC	None
	CHEMBL1078896	5731	0	UNDEFINED	-54	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	478	9	2	7	5.1	CCOc1cc(CN2CCC(Nc3nc4cc(NC(=O)C5CCC5)ccc4o3)CC2)ccc1OC	None
	46882180	5764	0	UNDEFINED	-39	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	482	7	2	7	3.7	CCOc1cc(CN2CCC(Nc3nc4cc(Cl)c(S(N)(=O)=O)cc4o3)CC2)ccc1F	None
	CHEMBL1079180	5764	0	UNDEFINED	-39	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	482	7	2	7	3.7	CCOc1cc(CN2CCC(Nc3nc4cc(Cl)c(S(N)(=O)=O)cc4o3)CC2)ccc1F	None
	2662	11279	124	3H-LSD	-41	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
	CHEMBL118	11279	124	3H-LSD	-41	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
	10836	14329	13	3H-LSD	-3	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	3	1	1	1.8	CN[C@@H](C)Cc1ccccc1	None
	CHEMBL1201201	14329	13	3H-LSD	-3	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	3	1	1	1.8	CN[C@@H](C)Cc1ccccc1	None
	5210	33119	45	3H-5HT	-123	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	None
	CHEMBL1200765	33119	45	3H-5HT	-123	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	None
	CHEMBL1419	33119	45	3H-5HT	-123	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	None
	156391	46537	95	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
	CHEMBL1200806	46537	95	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
	CHEMBL154	46537	95	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
	4771	50259	26	3H-5HT	1	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	2	1	1	2.0	CC(C)(N)Cc1ccccc1	None
	CHEMBL1574	50259	26	3H-5HT	1	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	2	1	1	2.0	CC(C)(N)Cc1ccccc1	None
	2244	93798	96	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
	CHEMBL25	93798	96	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
	4076	96585	23	3H-KETANSERIN	-26	7	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	5	1	4	1.2	COc1cc(CCN)cc(OC)c1OC	None
	CHEMBL26687	96585	23	3H-KETANSERIN	-26	7	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	5	1	4	1.2	COc1cc(CCN)cc(OC)c1OC	None
	104870	98423	39	3H-MESULERGINE	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
	5374	98423	39	3H-MESULERGINE	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
	CHEMBL279085	98423	39	3H-MESULERGINE	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
	43815	186337	58	3H-5HT	-1995	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
	CHEMBL1708	186337	58	3H-5HT	-1995	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
	CHEMBL490	186337	58	3H-5HT	-1995	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
	54676228	192874	108	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	2	5	1.6	CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O	None
	CHEMBL527	192874	108	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	2	5	1.6	CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O	None
	4495	194860	87	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
	CHEMBL56367	194860	87	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
	54677470	198867	110	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
	CHEMBL1256873	198867	110	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
	CHEMBL599	198867	110	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
	5281600	201336	85	3H-LSD	-275	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
	CHEMBL63354	201336	85	3H-LSD	-275	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
	5656	201377	82	3H-5HT	-79	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
	CHEMBL637	201377	82	3H-5HT	-79	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
	4158	203630	21	3H-5HT	-141	20	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
	CHEMBL1722	203630	21	3H-5HT	-141	20	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
	CHEMBL796	203630	21	3H-5HT	-141	20	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
	4054	203790	64	3H-LSD	-1	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
	CHEMBL1699	203790	64	3H-LSD	-1	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
	CHEMBL807	203790	64	3H-LSD	-1	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
	6852400	214160	0	3H-KETANSERIN	-25118	21	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
	73759726	214160	0	3H-KETANSERIN	-25118	21	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
	3821	214549	0	3H-LSD	-1	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	237	2	1	2	2.9	CNC1(CCCCC1=O)C2=CC=CC=C2Cl	None
	None	214591	0	3H-MESULERGINE	-1862	19	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	246	2	1	4	1.6	CCCN1CCCC2C1CC3=CN=C(N=C3C2)N	None
	135269	214639	0	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	222	5	1	3	2.5	CCCCC(=O)OC1=CC=CC=C1C(=O)O	None
	23681059	214640	0	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O	None
	5018304	214641	0	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	317	4	1	3	0.0	C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+]	None
	3672	214642	0	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)CC1=CC=C(C=C1)C(C)C(=O)O	None
	84003	214643	0	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	376	6	5	7	-0.0	C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O	None
	123619	214644	0	3H-LSD	-1412	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	358	3	0	4	4.2	CC1=NC=C(C=C1)C2=NC=C(C=C2C3=CC=C(C=C3)S(=O)(=O)C)Cl	None
	119828	214645	0	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	5	1	5	3.5	CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C	None
	5090	214646	0	3H-LSD	-1348	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3	None
	None	214648	0	3H-LSD	-7	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	517	8	2	5	5.2	CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)NCCC4=CC=C(C=C4)NC(=O)C	None
	None	214704	0	3H-5HT	-1	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	4	1	1	4.6	CC(C)CC(C1(CCC1)C2=CC=C(C=C2)Cl)N.Cl	None
	None	214747	0	3H-LSD	-4570	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	347	6	0	3	5.0	CC(=O)N(CC1=CC=CC=C1OC)C2=CC=CC=C2OC3=CC=CC=C3	None
	1150	3817	116	3H-5HT	-2	24	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3817	116	3H-5HT	-2	24	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3817	116	3H-5HT	-2	24	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3817	116	3H-5HT	-2	24	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	185	3943	54	3H-5HT	-2344	37	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	5311271	3943	54	3H-5HT	-2344	37	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	CHEMBL74355	3943	54	3H-5HT	-2344	37	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	DB16351	3943	54	3H-5HT	-2344	37	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	62787	204467	17	3H-5HT	-10	9	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	195	4	1	3	1.6	COc1ccc(OC)c(CC(C)N)c1	None
	CHEMBL8642	204467	17	3H-5HT	-10	9	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	195	4	1	3	1.6	COc1ccc(OC)c(CC(C)N)c1	None
	None	214366	0	3H-LSD	-1071	23	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	772	16	4	10	5.5	CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.C(=CC(=O)O)C(=O)O	None
	102	4064	44	3H-5HT	-100	49	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4064	44	3H-5HT	-100	49	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4064	44	3H-5HT	-100	49	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4064	44	3H-5HT	-100	49	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4064	44	3H-5HT	-100	49	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	141	1399	32	3H-LSD	-1	21	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	6089	1399	32	3H-LSD	-1	21	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	CHEMBL12420	1399	32	3H-LSD	-1	21	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	DB01488	1399	32	3H-LSD	-1	21	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	3668	214352	0	3H-LSD	-977	10	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	510	5	4	9	0.4	CNC(=O)C1C(C(C(O1)N2C=NC3=C2N=CN=C3NCC4=CC(=CC=C4)I)O)O	None
	146	135	80	3H-5HT	-1	3	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	178	2	2	1	1.8	NCCc1c[nH]c2c1cc(F)cc2	None
	164682	135	80	3H-5HT	-1	3	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	178	2	2	1	1.8	NCCc1c[nH]c2c1cc(F)cc2	None
	CHEMBL275628	135	80	3H-5HT	-1	3	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	178	2	2	1	1.8	NCCc1c[nH]c2c1cc(F)cc2	None
	1621	2396	16	3H-KETANSERIN	-35	44	Bovine	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2396	16	3H-KETANSERIN	-35	44	Bovine	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2396	16	3H-KETANSERIN	-35	44	Bovine	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2396	16	3H-KETANSERIN	-35	44	Bovine	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2396	16	3H-KETANSERIN	-35	44	Bovine	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	15897	2817	0	3H-LSD	12	36	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2817	0	3H-LSD	12	36	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2817	0	3H-LSD	12	36	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	15897	2817	0	3H-5-HT	12	36	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	15897	2817	0	3H-5HT	12	36	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2817	0	3H-5-HT	12	36	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2817	0	3H-5HT	12	36	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2817	0	3H-5-HT	12	36	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2817	0	3H-5HT	12	36	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	5	139	66	3H-5HT	-29	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-5HT	-29	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-5HT	-29	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-5HT	-29	54	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	152	361	18	3H-5HT	1	18	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	2107	361	18	3H-5HT	1	18	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	CHEMBL275854	361	18	3H-5HT	1	18	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	135398745	2869	108	3H-5HT	-5	65	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2869	108	3H-5HT	-5	65	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2869	108	3H-5HT	-5	65	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2869	108	3H-5HT	-5	65	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	152	361	18	3H-5HT	1	18	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	2107	361	18	3H-5HT	1	18	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	CHEMBL275854	361	18	3H-5HT	1	18	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	45486902	195271	0	UNDEFINED	-3	2	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	449	5	2	4	4.6	O=c1[nH]c2cccc(OCC3CCN(CC4CCc5[nH]c6ccc(F)cc6c5C4)CC3)c2o1	None
	CHEMBL566396	195271	0	UNDEFINED	-3	2	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	449	5	2	4	4.6	O=c1[nH]c2cccc(OCC3CCN(CC4CCc5[nH]c6ccc(F)cc6c5C4)CC3)c2o1	None
	1150	3817	116	3H-5HT	-8	24	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3817	116	3H-5HT	-8	24	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3817	116	3H-5HT	-8	24	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3817	116	3H-5HT	-8	24	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	1150	3817	116	3H-5HT	-8	24	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3817	116	3H-5HT	-8	24	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3817	116	3H-5HT	-8	24	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3817	116	3H-5HT	-8	24	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	77590	214176	0	3H-5HT	-15	6	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	124	4	0	2	0.8	COCCOCCl	None
	2389	3279	114	35S-GTPGammaS	-63	67	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3279	114	35S-GTPGammaS	-63	67	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3279	114	35S-GTPGammaS	-63	67	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3279	114	35S-GTPGammaS	-63	67	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3279	114	35S-GTPGammaS	-63	67	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	542051	204380	4	3H-5HT	-128	7	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	237	6	1	3	2.5	CCCc1cc(OC)c(CC(C)N)cc1OC	None
	CHEMBL8569	204380	4	3H-5HT	-128	7	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	237	6	1	3	2.5	CCCc1cc(OC)c(CC(C)N)cc1OC	None
	1809	134	28	3H-5HT	-999	36	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	28	3H-5HT	-999	36	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	28	3H-5HT	-999	36	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	5	139	66	3H-5HT	-13	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-5HT	-13	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-5HT	-13	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-5HT	-13	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	199	389	0	3H-5HT	-5	4	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	None
	9821951	389	0	3H-5HT	-5	4	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	None
	CHEMBL160293	389	0	3H-5HT	-5	4	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	None
	135398745	2869	108	35S-GTPGammaS	-5	65	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2869	108	35S-GTPGammaS	-5	65	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2869	108	35S-GTPGammaS	-5	65	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2869	108	35S-GTPGammaS	-5	65	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	135	2496	38	3H-5HT	-3	57	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2496	38	3H-5HT	-3	57	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2496	38	3H-5HT	-3	57	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2496	38	3H-5HT	-3	57	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2496	38	3H-5HT	-3	57	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	7153	97570	74	3H-MESULERGINE	-1	33	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97570	74	3H-MESULERGINE	-1	33	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	134	2478	19	125I-DOI	-10	67	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2478	19	125I-DOI	-10	67	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2478	19	125I-DOI	-10	67	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2478	19	125I-DOI	-10	67	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2478	19	125I-DOI	-10	67	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	None	214703	0	Functional	-1	27	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
	None	214703	0	UNDEFINED	-1	27	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
	None	214168	0	3H-KETANSERIN	-851	23	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
	2202	3083	91	3H-MESULERGINE	-6	21	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
	4850	3083	91	3H-MESULERGINE	-6	21	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
	49	3083	91	3H-MESULERGINE	-6	21	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
	CHEMBL1371770	3083	91	3H-MESULERGINE	-6	21	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
	DB12478	3083	91	3H-MESULERGINE	-6	21	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
	221	3435	63	3H-5HT	-4	13	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	3277600	3435	63	3H-5HT	-4	13	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	CHEMBL323356	3435	63	3H-5HT	-4	13	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	5	139	66	125I-DOI	-2951	54	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	125I-DOI	-2951	54	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	125I-DOI	-2951	54	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	125I-DOI	-2951	54	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	1809	134	28	3H-5HT	-999	36	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	28	3H-5HT	-999	36	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	28	3H-5HT	-999	36	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	173	3211	88	3H-5HT	-3	22	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	5011	3211	88	3H-5HT	-3	22	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	CHEMBL18772	3211	88	3H-5HT	-3	22	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	None	214461	0	3H-5HT	-120	15	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	438	5	1	4	4.8	C1CC(CCC1CCN2CCC3=C(C2)C=CC(=C3)C#N)NC(=O)C4=CC=NC5=CC=CC=C45	None
	179	396	107	3H-LSD	-17	50	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	2159	396	107	3H-LSD	-17	50	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	963	396	107	3H-LSD	-17	50	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	CHEMBL243712	396	107	3H-LSD	-17	50	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	DB06288	396	107	3H-LSD	-17	50	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	77379	18856	66	3H-5HT	-2	2	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	194	2	2	1	2.3	NCCc1c[nH]c2ccc(Cl)cc12	None
	CHEMBL1288716	18856	66	3H-5HT	-2	2	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	194	2	2	1	2.3	NCCc1c[nH]c2ccc(Cl)cc12	None
	102	4064	44	3H-RAUWOLSCINE	-93	49	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4064	44	3H-RAUWOLSCINE	-93	49	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4064	44	3H-RAUWOLSCINE	-93	49	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4064	44	3H-RAUWOLSCINE	-93	49	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4064	44	3H-RAUWOLSCINE	-93	49	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	5	139	66	3H-5HT	-13	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-5HT	-13	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-5HT	-13	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-5HT	-13	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	77158	18857	48	3H-5HT	2	2	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	238	2	2	1	2.4	NCCc1c[nH]c2ccc(Br)cc12	None
	CHEMBL1288717	18857	48	3H-5HT	2	2	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	238	2	2	1	2.4	NCCc1c[nH]c2ccc(Br)cc12	None
	None	215731	0	UNDEFINED	-14	3	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	421	4	3	4	3.3	C1CC2=C(CC1CNCC3COC4=C(O3)C=CC5=C4CC(=O)N5)C6=C(N2)C=CC(=C6)F	None
	145	140	48	3H-KETANSERIN	-251	29	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	1832	140	48	3H-KETANSERIN	-251	29	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL7257	140	48	3H-KETANSERIN	-251	29	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB14010	140	48	3H-KETANSERIN	-251	29	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	1150	3817	116	3H-KETANSERIN	-56	24	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3817	116	3H-KETANSERIN	-56	24	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3817	116	3H-KETANSERIN	-56	24	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3817	116	3H-KETANSERIN	-56	24	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	173	3211	88	3H-5HT	-3	22	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	5011	3211	88	3H-5HT	-3	22	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	CHEMBL18772	3211	88	3H-5HT	-3	22	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	25058166	214181	0	3H-MESULERGINE	-66	26	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	6852389	214181	0	3H-MESULERGINE	-66	26	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	2470	3596	46	3H-5HT	-14125	59	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3596	46	3H-5HT	-14125	59	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3596	46	3H-5HT	-14125	59	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3596	46	3H-5HT	-14125	59	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3596	46	3H-5HT	-14125	59	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	2470	3596	46	3H-5HT	-14125	59	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3596	46	3H-5HT	-14125	59	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3596	46	3H-5HT	-14125	59	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3596	46	3H-5HT	-14125	59	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3596	46	3H-5HT	-14125	59	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	None	214168	0	3H-5HT	-33	23	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
	130	3444	43	3H-5HT	-478	13	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	3378093	3444	43	3H-5HT	-478	13	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	CHEMBL281350	3444	43	3H-5HT	-478	13	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	240	931	39	3H-5HT	-26	25	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	2769	931	39	3H-5HT	-26	25	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	44279790	931	39	3H-5HT	-26	25	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	660	931	39	3H-5HT	-26	25	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL1729	931	39	3H-5HT	-26	25	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL560739	931	39	3H-5HT	-26	25	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	DB00604	931	39	3H-5HT	-26	25	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	2105	3005	34	3H-LSD	-28	33	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	47811	3005	34	3H-LSD	-28	33	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	48	3005	34	3H-LSD	-28	33	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	CHEMBL531	3005	34	3H-LSD	-28	33	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	DB01186	3005	34	3H-LSD	-28	33	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	138107169	214173	0	3H-5HT	-33	22	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	22831402	214173	0	3H-5HT	-33	22	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	186	1777	47	3H-LSD	-338	16	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
	71781	1777	47	3H-LSD	-338	16	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
	CHEMBL18972	1777	47	3H-LSD	-338	16	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
	1353	1880	85	3H-5HT	-295	85	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1880	85	3H-5HT	-295	85	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1880	85	3H-5HT	-295	85	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1880	85	3H-5HT	-295	85	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1880	85	3H-5HT	-295	85	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	None	214161	0	3H-5HT	-2398	20	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
	1809	134	28	3H-5HT	-1659	36	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	28	3H-5HT	-1659	36	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	28	3H-5HT	-1659	36	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	124	2933	44	3H-5HT	-181	32	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
	2032	2933	44	3H-5HT	-181	32	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
	4636	2933	44	3H-5HT	-181	32	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
	CHEMBL762	2933	44	3H-5HT	-181	32	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
	DB00935	2933	44	3H-5HT	-181	32	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
	15897	2817	0	3H-LSD	12	36	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2817	0	3H-LSD	12	36	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2817	0	3H-LSD	12	36	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	138107169	214173	0	3H-5HT	-33	22	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	22831402	214173	0	3H-5HT	-33	22	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	None	214161	0	3H-LSD	-407	20	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
	1809	134	28	Functional	-999	36	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	28	Functional	-999	36	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	28	Functional	-999	36	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	221	3435	63	UNDEFINED	4	13	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	3277600	3435	63	UNDEFINED	4	13	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	CHEMBL323356	3435	63	UNDEFINED	4	13	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	6446436	214706	0	3H-MESULERGINE	-1	2	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	370	4	3	4	3.2	CC1=CC2=C(C=C1)C(C3=C2N(C=C3)CC(C)N)(C)C.C(=CC(=O)O)C(=O)O	None
	134	2478	19	Functional	-2	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2478	19	Functional	-2	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2478	19	Functional	-2	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2478	19	Functional	-2	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2478	19	Functional	-2	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1614	201960	22	Functional	2	9	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	179	2	1	3	1.3	CC(N)Cc1ccc2c(c1)OCO2	None
	CHEMBL6731	201960	22	Functional	2	9	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	179	2	1	3	1.3	CC(N)Cc1ccc2c(c1)OCO2	None
	1809	134	28	3H-5HT	-1659	36	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	28	3H-5HT	-1659	36	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	28	3H-5HT	-1659	36	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	107992	2516	47	3H-MESULERGINE	-1	9	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	165	2516	47	3H-MESULERGINE	-1	9	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	CHEMBL269521	2516	47	3H-MESULERGINE	-1	9	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	DB12111	2516	47	3H-MESULERGINE	-1	9	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	28	3440	37	3H-5HT	-954	10	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	3292447	3440	37	3H-5HT	-954	10	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	CHEMBL20963	3440	37	3H-5HT	-954	10	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	2470	3596	46	3H-5HT	-14125	59	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3596	46	3H-5HT	-14125	59	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3596	46	3H-5HT	-14125	59	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3596	46	3H-5HT	-14125	59	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3596	46	3H-5HT	-14125	59	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	2389	3279	114	3H-LSD	-63	67	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3279	114	3H-LSD	-63	67	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3279	114	3H-LSD	-63	67	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3279	114	3H-LSD	-63	67	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3279	114	3H-LSD	-63	67	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	107	141	116	3H-5HT	-4	30	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	116	3H-5HT	-4	30	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	116	3H-5HT	-4	30	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	None	214168	0	3H-5HT	-12	23	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
	None	215733	0	UNDEFINED	-12	3	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	432	3	2	4	3.8	C1CC2=C(CC1CN3CC4CC3CN4C5=CC=CC6=C5OC(=O)N6)C7=C(N2)C=CC(=C7)F	None
	105432	214254	0	3H-5HT	-30	4	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	240	5	1	5	1.5	CC(CC1=CC(=C(C=C1OC)[N+](=O)[O-])OC)N	None
	18971832	2385	0	3H-5HT	-263	13	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
	21	2385	0	3H-5HT	-263	13	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
	CHEMBL3186179	2385	0	3H-5HT	-263	13	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
	37459	735	10	3H-KETANSERIN	-39	24	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	62	735	10	3H-KETANSERIN	-39	24	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	CHEMBL8514	735	10	3H-KETANSERIN	-39	24	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	None	214168	0	3H-5HT	-12	23	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
	5268	3599	34	3H-RAUWOLSCINE	-1047	17	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
	53	3599	34	3H-RAUWOLSCINE	-1047	17	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
	CHEMBL300555	3599	34	3H-RAUWOLSCINE	-1047	17	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
	173	3211	88	Functional	1	22	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	5011	3211	88	Functional	1	22	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	CHEMBL18772	3211	88	Functional	1	22	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	1353	1880	85	3H-5HT	-295	85	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1880	85	3H-5HT	-295	85	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1880	85	3H-5HT	-295	85	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1880	85	3H-5HT	-295	85	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1880	85	3H-5HT	-295	85	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	119607	214647	0	3H-LSD	97	28	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	CC1=C(C(=NO1)C2=CC=CC=C2)C3=CC=C(C=C3)S(=O)(=O)N	None
	1809	134	28	3H-5HT	-999	36	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	28	3H-5HT	-999	36	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	28	3H-5HT	-999	36	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	31016	101817	12	3H-5HT	-11	5	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	225	5	1	4	1.6	COc1cc(CC(C)N)cc(OC)c1OC	None
	CHEMBL30336	101817	12	3H-5HT	-11	5	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	225	5	1	4	1.6	COc1cc(CC(C)N)cc(OC)c1OC	None
	213	3792	50	3H-LSD	-3	43	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	2717	3792	50	3H-LSD	-3	43	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	5533	3792	50	3H-LSD	-3	43	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	CHEMBL621	3792	50	3H-LSD	-3	43	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	DB00656	3792	50	3H-LSD	-3	43	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	5	139	66	3H-5HT	-13	54	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-5HT	-13	54	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-5HT	-13	54	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-5HT	-13	54	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	134	2478	19	3H-LSD	-2	67	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2478	19	3H-LSD	-2	67	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2478	19	3H-LSD	-2	67	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2478	19	3H-LSD	-2	67	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2478	19	3H-LSD	-2	67	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	11957541	1430	38	3H-5HT	-1	15	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	1229	1430	38	3H-5HT	-1	15	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	147	1430	38	3H-5HT	-1	15	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	170617	1430	38	3H-5HT	-1	15	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	CHEMBL6616	1430	38	3H-5HT	-1	15	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	7153	97570	74	3H-LSD	-1	33	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97570	74	3H-LSD	-1	33	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	135	2496	38	3H-5HT	-3	57	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2496	38	3H-5HT	-3	57	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2496	38	3H-5HT	-3	57	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2496	38	3H-5HT	-3	57	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2496	38	3H-5HT	-3	57	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	3652	4034	72	3H-5HT	-2	18	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	57	4034	72	3H-5HT	-2	18	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	60809	4034	72	3H-5HT	-2	18	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	CHEMBL21536	4034	72	3H-5HT	-2	18	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	DB15357	4034	72	3H-5HT	-2	18	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	5268	3599	34	3H-5HT	-616	17	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
	53	3599	34	3H-5HT	-616	17	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
	CHEMBL300555	3599	34	3H-5HT	-616	17	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
	1574	81	52	3H-5HT	-2	20	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	218	81	52	3H-5HT	-2	20	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	CHEMBL266591	81	52	3H-5HT	-2	20	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	135	2496	38	3H-5HT	-37	57	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2496	38	3H-5HT	-37	57	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2496	38	3H-5HT	-37	57	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2496	38	3H-5HT	-37	57	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2496	38	3H-5HT	-37	57	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1150	3817	116	125I-DOI	-8	24	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	1150	3817	116	3H-5HT	-8	24	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3817	116	125I-DOI	-8	24	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3817	116	3H-5HT	-8	24	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3817	116	125I-DOI	-8	24	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3817	116	3H-5HT	-8	24	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3817	116	125I-DOI	-8	24	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3817	116	3H-5HT	-8	24	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	152	361	18	Functional	1	18	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	2107	361	18	Functional	1	18	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	CHEMBL275854	361	18	Functional	1	18	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	5	139	66	Functional	-13	54	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	Functional	-13	54	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	Functional	-13	54	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	Functional	-13	54	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	4106	2466	16	3H-5HT	-3	33	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2466	16	3H-5HT	-3	33	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2466	16	3H-5HT	-3	33	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2466	16	3H-5HT	-3	33	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5074	3280	75	3H-5HT	-3	29	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3280	75	3H-5HT	-3	29	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3280	75	3H-5HT	-3	29	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3280	75	3H-5HT	-3	29	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	None	214281	0	3H-LSD	-2	7	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	339	4	3	3	1.9	CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
	133	2460	48	3H-KETANSERIN	-4	42	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2460	48	3H-KETANSERIN	-4	42	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2460	48	3H-KETANSERIN	-4	42	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2460	48	3H-KETANSERIN	-4	42	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2460	48	3H-KETANSERIN	-4	42	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1524	2150	89	3H-KETANSERIN	-1	51	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2150	89	3H-KETANSERIN	-1	51	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2150	89	3H-KETANSERIN	-1	51	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2150	89	3H-KETANSERIN	-1	51	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2150	89	3H-KETANSERIN	-1	51	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2150	89	3H-KETANSERIN	-1	51	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	None	214630	0	3H-5HT	5	4	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	342	4	3	4	2.5	CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N.C(=CC(=O)O)C(=O)O	None
	191	3442	47	3H-5HT	-1	3	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	None
	443389	3442	47	3H-5HT	-1	3	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	None
	CHEMBL276140	3442	47	3H-5HT	-1	3	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	None
	None	214629	0	3H-5HT	-2	11	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	243	3	1	4	2.7	CCC1=CC2=C(O1)C=CC3=C2N(N=C3)CC(C)N	None
	135409468	2004	63	3H-LSD	1	40	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
	333	2004	63	3H-LSD	1	40	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
	CHEMBL845	2004	63	3H-LSD	1	40	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
	5	139	66	3H-MESULERGINE	-13	54	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-MESULERGINE	-13	54	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-MESULERGINE	-13	54	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-MESULERGINE	-13	54	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	155	719	20	Functional	-5	12	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	163	719	20	Functional	-5	12	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	62065	719	20	Functional	-5	12	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	CHEMBL6607	719	20	Functional	-5	12	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	DB01484	719	20	Functional	-5	12	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	1588	2294	24	3H-LSD	-8	43	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2294	24	3H-LSD	-8	43	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2294	24	3H-LSD	-8	43	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2294	24	3H-LSD	-8	43	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2294	24	3H-LSD	-8	43	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	None	214526	0	3H-LSD	-32	11	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	426	6	0	6	3.4	C1CCC2C(C1)C(=O)N(C2=O)CCCCN3CCN(CC3)C4=NSC5=CC=CC=C54	None
	11957541	1430	38	3H-5HT	-1	15	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	1229	1430	38	3H-5HT	-1	15	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	147	1430	38	3H-5HT	-1	15	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	170617	1430	38	3H-5HT	-1	15	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	CHEMBL6616	1430	38	3H-5HT	-1	15	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	11957541	1430	38	3H-5HT	-1	15	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	1229	1430	38	3H-5HT	-1	15	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	147	1430	38	3H-5HT	-1	15	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	170617	1430	38	3H-5HT	-1	15	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	CHEMBL6616	1430	38	3H-5HT	-1	15	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	1615	167228	22	Functional	-2	44	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
	CHEMBL43048	167228	22	Functional	-2	44	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
	2389	3279	114	3H-5HT	-524	67	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3279	114	3H-5HT	-524	67	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3279	114	3H-5HT	-524	67	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3279	114	3H-5HT	-524	67	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3279	114	3H-5HT	-524	67	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	1524	2150	89	125I-DOI	-147	51	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2150	89	125I-DOI	-147	51	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2150	89	125I-DOI	-147	51	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2150	89	125I-DOI	-147	51	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2150	89	125I-DOI	-147	51	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2150	89	125I-DOI	-147	51	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	189	3436	31	3H-LSD	-5	17	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	5163	3436	31	3H-LSD	-5	17	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	CHEMBL297784	3436	31	3H-LSD	-5	17	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	155	719	20	3H-5HT	-10	12	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	163	719	20	3H-5HT	-10	12	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	62065	719	20	3H-5HT	-10	12	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	CHEMBL6607	719	20	3H-5HT	-10	12	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	DB01484	719	20	3H-5HT	-10	12	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	202	1480	0	3H-5HT	-1	31	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	60835	1480	0	3H-5HT	-1	31	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	972	1480	0	3H-5HT	-1	31	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	CHEMBL1175	1480	0	3H-5HT	-1	31	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	DB00476	1480	0	3H-5HT	-1	31	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	2477	734	54	3H-5HT	-13	28	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	36	734	54	3H-5HT	-13	28	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	437	734	54	3H-5HT	-13	28	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	CHEMBL49	734	54	3H-5HT	-13	28	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	DB00490	734	54	3H-5HT	-13	28	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	1524	2150	89	3H-RAUWOLSCINE	-218	51	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2150	89	3H-RAUWOLSCINE	-218	51	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2150	89	3H-RAUWOLSCINE	-218	51	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2150	89	3H-RAUWOLSCINE	-218	51	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2150	89	3H-RAUWOLSCINE	-218	51	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2150	89	3H-RAUWOLSCINE	-218	51	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	2176	3077	66	3H-5HT	-933	26	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	4828	3077	66	3H-5HT	-933	26	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	91	3077	66	3H-5HT	-933	26	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	CHEMBL500	3077	66	3H-5HT	-933	26	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	DB00960	3077	66	3H-5HT	-933	26	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	277	1274	55	125I-DOI	-26	45	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1274	55	125I-DOI	-26	45	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1274	55	125I-DOI	-26	45	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1274	55	125I-DOI	-26	45	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1274	55	125I-DOI	-26	45	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	189	3436	31	3H-5HT	-5	17	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	5163	3436	31	3H-5HT	-5	17	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	CHEMBL297784	3436	31	3H-5HT	-5	17	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	1220	186	46	3H-5HT	-1905	44	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	186	46	3H-5HT	-1905	44	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	186	46	3H-5HT	-1905	44	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	186	46	3H-5HT	-1905	44	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	6917970	3635	54	3H-LSD	-51	34	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
	8370	3635	54	3H-LSD	-51	34	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
	CHEMBL487387	3635	54	3H-LSD	-51	34	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
	1524	2150	89	3H-MESULERGINE	-218	51	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2150	89	3H-MESULERGINE	-218	51	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2150	89	3H-MESULERGINE	-218	51	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2150	89	3H-MESULERGINE	-218	51	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2150	89	3H-MESULERGINE	-218	51	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2150	89	3H-MESULERGINE	-218	51	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	104911	214249	0	3H-LSD	-99	36	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	530	7	0	5	5.1	COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl	None
	105432	214254	0	3H-5HT	-44	4	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	240	5	1	5	1.5	CC(CC1=CC(=C(C=C1OC)[N+](=O)[O-])OC)N	None
	1150	3817	116	3H-5HT	-2	24	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3817	116	3H-5HT	-2	24	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3817	116	3H-5HT	-2	24	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3817	116	3H-5HT	-2	24	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	7153	97570	74	3H-5HT	-1	33	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97570	74	3H-5HT	-1	33	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	7153	97570	74	UNDEFINED	-1	33	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97570	74	UNDEFINED	-1	33	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	None	214703	0	UNDEFINED	-1	27	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
	198	310	120	3H-MESULERGINE	-346	5	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	82148	310	120	3H-MESULERGINE	-346	5	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	99	310	120	3H-MESULERGINE	-346	5	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	CHEMBL10878	310	120	3H-MESULERGINE	-346	5	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	DB06594	310	120	3H-MESULERGINE	-346	5	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	None	214168	0	Functional	-33	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
	11957541	1430	38	3H-5HT	-4	15	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	1229	1430	38	3H-5HT	-4	15	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	147	1430	38	3H-5HT	-4	15	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	170617	1430	38	3H-5HT	-4	15	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	CHEMBL6616	1430	38	3H-5HT	-4	15	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	7153	97570	74	3H-5HT	-1	33	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97570	74	3H-5HT	-1	33	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	6166	214253	0	3H-5HT	-7	4	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	330	2	1	3	3.7	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)CO)CCC4=CC(=O)CC[C@]34C	None
	155	719	20	3H-5HT	-5	12	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	163	719	20	3H-5HT	-5	12	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	62065	719	20	3H-5HT	-5	12	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	CHEMBL6607	719	20	3H-5HT	-5	12	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	DB01484	719	20	3H-5HT	-5	12	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	7153	97570	74	3H-5HT	-1	33	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97570	74	3H-5HT	-1	33	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	57174031	214163	0	3H-KETANSERIN	-457	19	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	284	2	1	3	3.0	CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43	None
	185	3943	54	3H-LSD	-2344	37	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	5311271	3943	54	3H-LSD	-2344	37	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	CHEMBL74355	3943	54	3H-LSD	-2344	37	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	DB16351	3943	54	3H-LSD	-2344	37	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	3294	1975	106	3H-LSD	-38	44	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	71360	1975	106	3H-LSD	-38	44	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	87	1975	106	3H-LSD	-38	44	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	CHEMBL14376	1975	106	3H-LSD	-38	44	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	DB04946	1975	106	3H-LSD	-38	44	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	3337	214441	0	3H-LSD	-75	40	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	65801	214441	0	3H-LSD	-75	40	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	66264	214441	0	3H-LSD	-75	40	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	91452	214441	0	3H-LSD	-75	40	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	2865	4079	67	3H-5HT	-12	53	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4079	67	3H-5HT	-12	53	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4079	67	3H-5HT	-12	53	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4079	67	3H-5HT	-12	53	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4079	67	3H-5HT	-12	53	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	11957541	1430	38	3H-5HT	-4	15	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	1229	1430	38	3H-5HT	-4	15	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	147	1430	38	3H-5HT	-4	15	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	170617	1430	38	3H-5HT	-4	15	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	CHEMBL6616	1430	38	3H-5HT	-4	15	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	5	139	66	3H-5HT	-29	54	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-5HT	-29	54	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-5HT	-29	54	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-5HT	-29	54	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	11957541	1430	38	3H-5HT	-1	15	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	1229	1430	38	3H-5HT	-1	15	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	147	1430	38	3H-5HT	-1	15	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	170617	1430	38	3H-5HT	-1	15	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	CHEMBL6616	1430	38	3H-5HT	-1	15	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	7153	97570	74	3H-5HT	-1	33	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97570	74	3H-5HT	-1	33	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	7153	97570	74	3H-5HT	-1	33	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97570	74	3H-5HT	-1	33	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	138107169	214173	0	3H-5HT	-33	22	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	22831402	214173	0	3H-5HT	-33	22	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	1574	81	52	3H-5HT	-3	20	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	218	81	52	3H-5HT	-3	20	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	CHEMBL266591	81	52	3H-5HT	-3	20	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	1574	81	52	3H-5HT	-3	20	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	218	81	52	3H-5HT	-3	20	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	CHEMBL266591	81	52	3H-5HT	-3	20	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	115	3732	78	Functional	-1	26	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	4296	3732	78	Functional	-1	26	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	CHEMBL274866	3732	78	Functional	-1	26	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	2389	3279	114	3H-5HT	-63	67	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3279	114	3H-5HT	-63	67	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3279	114	3H-5HT	-63	67	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3279	114	3H-5HT	-63	67	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3279	114	3H-5HT	-63	67	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	1150	3817	116	Functional	-2	24	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3817	116	Functional	-2	24	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3817	116	Functional	-2	24	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3817	116	Functional	-2	24	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	107992	2516	47	Functional	-1	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	165	2516	47	Functional	-1	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	CHEMBL269521	2516	47	Functional	-1	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	DB12111	2516	47	Functional	-1	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	11954224	214174	0	3H-5HT	-66	59	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	None	214703	0	3H-MESULERGINE	1	27	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
	7153	97570	74	3H-5HT	-1	33	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97570	74	3H-5HT	-1	33	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	1342	36	42	3H-5HT	2	18	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3	36	42	3H-5HT	2	18	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	CHEMBL277120	36	42	3H-5HT	2	18	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	206	2457	10	3H-5HT	-1	24	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2457	10	3H-5HT	-1	24	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2457	10	3H-5HT	-1	24	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	135398737	944	89	3H-RAUWOLSCINE	-2	91	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	944	89	3H-RAUWOLSCINE	-2	91	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	944	89	3H-RAUWOLSCINE	-2	91	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	944	89	3H-RAUWOLSCINE	-2	91	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	944	89	3H-RAUWOLSCINE	-2	91	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	206	2457	10	3H-5HT	-1	24	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2457	10	3H-5HT	-1	24	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2457	10	3H-5HT	-1	24	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	242	467	117	3H-LSD	-1	51	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	467	117	3H-LSD	-1	51	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	467	117	3H-LSD	-1	51	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	467	117	3H-LSD	-1	51	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	467	117	3H-LSD	-1	51	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	11954224	214174	0	3H-5HT	-66	59	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	206	2457	10	3H-5HT	-1	24	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2457	10	3H-5HT	-1	24	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2457	10	3H-5HT	-1	24	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	5074	3280	75	125I-DOI	-6	29	Mouse	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3280	75	125I-DOI	-6	29	Mouse	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3280	75	125I-DOI	-6	29	Mouse	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3280	75	125I-DOI	-6	29	Mouse	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	1342	36	42	3H-5HT	2	18	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3	36	42	3H-5HT	2	18	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	CHEMBL277120	36	42	3H-5HT	2	18	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	1621	2396	16	3H-LSD	-19	44	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2396	16	3H-LSD	-19	44	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2396	16	3H-LSD	-19	44	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2396	16	3H-LSD	-19	44	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2396	16	3H-LSD	-19	44	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	1342	36	42	3H-5HT	2	18	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3	36	42	3H-5HT	2	18	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	CHEMBL277120	36	42	3H-5HT	2	18	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	1621	2396	16	3H-LSD	-39	44	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2396	16	3H-LSD	-39	44	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2396	16	3H-LSD	-39	44	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2396	16	3H-LSD	-39	44	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2396	16	3H-LSD	-39	44	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	None	214161	0	Functional	-407	20	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
	6971132	214235	0	3H-LSD	-7	14	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	268	1	2	2	2.1	CN1CC(C=C2C1CC3=CNC4=CC=CC2=C34)C(=O)O	None
	219050	3321	21	3H-MESULERGINE	-194	21	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
	52	3321	21	3H-MESULERGINE	-194	21	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
	CHEMBL431367	3321	21	3H-MESULERGINE	-194	21	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
	2470	3596	46	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3596	46	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3596	46	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3596	46	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3596	46	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	2	3210	19	3H-5HT	-363	28	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
	54562	3210	19	3H-5HT	-363	28	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
	CHEMBL240773	3210	19	3H-5HT	-363	28	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
	186	1777	47	3H-5HT	-338	16	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
	71781	1777	47	3H-5HT	-338	16	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
	CHEMBL18972	1777	47	3H-5HT	-338	16	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
	31016	101817	12	3H-5HT	-5	5	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	225	5	1	4	1.6	COc1cc(CC(C)N)cc(OC)c1OC	None
	CHEMBL30336	101817	12	3H-5HT	-5	5	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	225	5	1	4	1.6	COc1cc(CC(C)N)cc(OC)c1OC	None
	135398737	944	89	3H-5HT	-36	91	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	944	89	3H-5HT	-36	91	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	944	89	3H-5HT	-36	91	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	944	89	3H-5HT	-36	91	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	944	89	3H-5HT	-36	91	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	102	4064	44	3H-5HT	-93	49	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4064	44	3H-5HT	-93	49	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4064	44	3H-5HT	-93	49	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4064	44	3H-5HT	-93	49	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4064	44	3H-5HT	-93	49	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	7153	97570	74	3H-5HT	-1	33	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97570	74	3H-5HT	-1	33	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	None	214168	0	3H-5HT	-33	23	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
	6166	214253	0	3H-5HT	-4	4	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	330	2	1	3	3.7	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)CO)CCC4=CC(=O)CC[C@]34C	None
	1574	81	52	3H-5HT	-3	20	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	218	81	52	3H-5HT	-3	20	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	CHEMBL266591	81	52	3H-5HT	-3	20	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	130	3444	43	35S-GTPGammaS	-478	13	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	3378093	3444	43	35S-GTPGammaS	-478	13	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	CHEMBL281350	3444	43	35S-GTPGammaS	-478	13	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	2470	3596	46	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3596	46	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3596	46	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3596	46	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3596	46	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	1524	2150	89	3H-5HT	-2570	51	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2150	89	3H-5HT	-2570	51	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2150	89	3H-5HT	-2570	51	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2150	89	3H-5HT	-2570	51	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2150	89	3H-5HT	-2570	51	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2150	89	3H-5HT	-2570	51	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	2470	3596	46	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3596	46	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3596	46	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3596	46	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3596	46	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	2470	3596	46	3H-RAUWOLSCINE	-14125	59	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3596	46	3H-RAUWOLSCINE	-14125	59	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3596	46	3H-RAUWOLSCINE	-14125	59	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3596	46	3H-RAUWOLSCINE	-14125	59	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3596	46	3H-RAUWOLSCINE	-14125	59	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	7153	97570	74	3H-5HT	-1	33	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97570	74	3H-5HT	-1	33	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	1524	2150	89	3H-5HT	-218	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2150	89	3H-5HT	-218	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2150	89	3H-5HT	-218	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2150	89	3H-5HT	-218	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2150	89	3H-5HT	-218	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2150	89	3H-5HT	-218	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	1524	2150	89	3H-5HT	-2570	51	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2150	89	3H-5HT	-2570	51	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2150	89	3H-5HT	-2570	51	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2150	89	3H-5HT	-2570	51	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2150	89	3H-5HT	-2570	51	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2150	89	3H-5HT	-2570	51	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	2470	3596	46	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3596	46	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3596	46	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3596	46	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3596	46	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	15760	112580	55	3H-5HT	-5	2	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	174	2	2	1	2.0	Cc1ccc2[nH]cc(CCN)c2c1	None
	CHEMBL331241	112580	55	3H-5HT	-5	2	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	174	2	2	1	2.0	Cc1ccc2[nH]cc(CCN)c2c1	None
	None	214161	0	3H-LSD	-407	20	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
	186	1777	47	3H-5HT	-338	16	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
	71781	1777	47	3H-5HT	-338	16	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
	CHEMBL18972	1777	47	3H-5HT	-338	16	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
	2470	3596	46	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3596	46	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3596	46	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3596	46	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3596	46	3H-5HT	-120226	59	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	138107169	214173	0	3H-5HT	-117	22	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	22831402	214173	0	3H-5HT	-117	22	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	138107169	214173	0	3H-5HT	-117	22	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	22831402	214173	0	3H-5HT	-117	22	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	206	2457	10	3H-5HT	-26	24	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2457	10	3H-5HT	-26	24	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2457	10	3H-5HT	-26	24	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	1524	2150	89	3H-5HT	-2570	51	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2150	89	3H-5HT	-2570	51	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2150	89	3H-5HT	-2570	51	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2150	89	3H-5HT	-2570	51	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2150	89	3H-5HT	-2570	51	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2150	89	3H-5HT	-2570	51	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	1524	2150	89	3H-5HT	-2570	51	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2150	89	3H-5HT	-2570	51	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2150	89	3H-5HT	-2570	51	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2150	89	3H-5HT	-2570	51	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2150	89	3H-5HT	-2570	51	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2150	89	3H-5HT	-2570	51	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	206	2457	10	3H-5HT	-26	24	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2457	10	3H-5HT	-26	24	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2457	10	3H-5HT	-26	24	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	7153	97570	74	3H-5HT	-1	33	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97570	74	3H-5HT	-1	33	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	1353	1880	85	3H-5HT	-295	85	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1880	85	3H-5HT	-295	85	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1880	85	3H-5HT	-295	85	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1880	85	3H-5HT	-295	85	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1880	85	3H-5HT	-295	85	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	1524	2150	89	3H-5HT	-218	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	1524	2150	89	3H-KETANSERIN	-218	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2150	89	3H-5HT	-218	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2150	89	3H-KETANSERIN	-218	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2150	89	3H-5HT	-218	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2150	89	3H-KETANSERIN	-218	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2150	89	3H-5HT	-218	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2150	89	3H-KETANSERIN	-218	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2150	89	3H-5HT	-218	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2150	89	3H-KETANSERIN	-218	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2150	89	3H-5HT	-218	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2150	89	3H-KETANSERIN	-218	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	1524	2150	89	3H-5HT	-218	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2150	89	3H-5HT	-218	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2150	89	3H-5HT	-218	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2150	89	3H-5HT	-218	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2150	89	3H-5HT	-218	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2150	89	3H-5HT	-218	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	2220	3085	78	3H-5HT	-10	13	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	27400	3085	78	3H-5HT	-10	13	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	93	3085	78	3H-5HT	-10	13	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	CHEMBL294951	3085	78	3H-5HT	-10	13	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	DB06153	3085	78	3H-5HT	-10	13	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	77158	18857	48	3H-5HT	-2	2	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	238	2	2	1	2.4	NCCc1c[nH]c2ccc(Br)cc12	None
	CHEMBL1288717	18857	48	3H-5HT	-2	2	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	238	2	2	1	2.4	NCCc1c[nH]c2ccc(Br)cc12	None
	2402	3318	58	3H-MESULERGINE	-9	25	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	5095	3318	58	3H-MESULERGINE	-9	25	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	7295	3318	58	3H-MESULERGINE	-9	25	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	CHEMBL589	3318	58	3H-MESULERGINE	-9	25	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	DB00268	3318	58	3H-MESULERGINE	-9	25	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	145	140	48	3H-LSD	-87	29	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	1832	140	48	3H-LSD	-87	29	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL7257	140	48	3H-LSD	-87	29	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB14010	140	48	3H-LSD	-87	29	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	77158	18857	48	3H-5HT	-2	2	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	238	2	2	1	2.4	NCCc1c[nH]c2ccc(Br)cc12	None
	CHEMBL1288717	18857	48	3H-5HT	-2	2	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	238	2	2	1	2.4	NCCc1c[nH]c2ccc(Br)cc12	None
	206	2457	10	3H-5HT	-26	24	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2457	10	3H-5HT	-26	24	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2457	10	3H-5HT	-26	24	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	138107169	214173	0	3H-5HT	-117	22	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	22831402	214173	0	3H-5HT	-117	22	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	115	3732	78	3H-5HT	-1	26	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	4296	3732	78	3H-5HT	-1	26	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	CHEMBL274866	3732	78	3H-5HT	-1	26	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	3337	214441	0	3H-LSD	-75	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	65801	214441	0	3H-LSD	-75	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	66264	214441	0	3H-LSD	-75	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	91452	214441	0	3H-LSD	-75	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	1524	2150	89	3H-5HT	-218	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2150	89	3H-5HT	-218	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2150	89	3H-5HT	-218	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2150	89	3H-5HT	-218	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2150	89	3H-5HT	-218	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2150	89	3H-5HT	-218	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	102	4064	44	3H-5HT	-93	49	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4064	44	3H-5HT	-93	49	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4064	44	3H-5HT	-93	49	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4064	44	3H-5HT	-93	49	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4064	44	3H-5HT	-93	49	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	102	4064	44	3H-5HT	-93	49	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4064	44	3H-5HT	-93	49	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4064	44	3H-5HT	-93	49	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4064	44	3H-5HT	-93	49	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4064	44	3H-5HT	-93	49	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	1524	2150	89	3H-5HT	-2570	51	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2150	89	3H-5HT	-2570	51	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2150	89	3H-5HT	-2570	51	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2150	89	3H-5HT	-2570	51	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2150	89	3H-5HT	-2570	51	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2150	89	3H-5HT	-2570	51	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	5	139	66	3H-5HT	-13	54	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-5HT	-13	54	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-5HT	-13	54	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-5HT	-13	54	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	135398737	944	89	3H-LSD	-2	91	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	944	89	3H-LSD	-2	91	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	944	89	3H-LSD	-2	91	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	944	89	3H-LSD	-2	91	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	944	89	3H-LSD	-2	91	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	138107169	214173	0	3H-RAUWOLSCINE	-33	22	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	22831402	214173	0	3H-RAUWOLSCINE	-33	22	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	135	2496	38	3H-5HT	-3	57	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2496	38	3H-5HT	-3	57	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2496	38	3H-5HT	-3	57	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2496	38	3H-5HT	-3	57	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2496	38	3H-5HT	-3	57	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	2865	4079	67	3H-LSD	-12	53	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4079	67	3H-LSD	-12	53	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4079	67	3H-LSD	-12	53	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4079	67	3H-LSD	-12	53	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4079	67	3H-LSD	-12	53	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	1342	36	42	3H-5HT	-4	18	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3	36	42	3H-5HT	-4	18	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	CHEMBL277120	36	42	3H-5HT	-4	18	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3117	206106	100	None	-8	16	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	None
	CHEMBL964	206106	100	None	-8	16	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	None
	104903	56050	14	None	-4	6	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	None
	CHEMBL1630578	56050	14	None	-4	6	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	None
	7153	97570	74	3H-5HT	-1	33	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97570	74	3H-5HT	-1	33	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	102	4064	44	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4064	44	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4064	44	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4064	44	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4064	44	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	7153	97570	74	3H-5HT	-1	33	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97570	74	3H-5HT	-1	33	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	164	1432	17	3H-KETANSERIN	-17	9	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	209	4	1	3	1.9	COc1cc(C)c(cc1CC(N)C)OC	None
	85875	1432	17	3H-KETANSERIN	-17	9	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	209	4	1	3	1.9	COc1cc(C)c(cc1CC(N)C)OC	None
	CHEMBL8600	1432	17	3H-KETANSERIN	-17	9	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	209	4	1	3	1.9	COc1cc(C)c(cc1CC(N)C)OC	None
	DB01528	1432	17	3H-KETANSERIN	-17	9	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	209	4	1	3	1.9	COc1cc(C)c(cc1CC(N)C)OC	None
	3337	214441	0	Functional	-75	40	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	65801	214441	0	Functional	-75	40	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	66264	214441	0	Functional	-75	40	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	91452	214441	0	Functional	-75	40	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	None	215730	0	UNDEFINED	-83	3	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	449	6	3	4	4.1	C1CC2=C(CC1CCCNCC3COC4=C(O3)C=CC5=C4CC(=O)N5)NC6=C2C=C(C=C6)F	None
	107992	2516	47	3H-5HT	-5	9	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	165	2516	47	3H-5HT	-5	9	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	CHEMBL269521	2516	47	3H-5HT	-5	9	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	DB12111	2516	47	3H-5HT	-5	9	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	1220	186	46	3H-5HT	-1905	44	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	186	46	3H-5HT	-1905	44	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	186	46	3H-5HT	-1905	44	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	186	46	3H-5HT	-1905	44	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	11848624	88716	0	UNDEFINED	2	6	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	381	7	1	6	4.3	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1OC	None
	CHEMBL236587	88716	0	UNDEFINED	2	6	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	381	7	1	6	4.3	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1OC	None
	2389	3279	114	3H-LSD	-63	67	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3279	114	3H-LSD	-63	67	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3279	114	3H-LSD	-63	67	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3279	114	3H-LSD	-63	67	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3279	114	3H-LSD	-63	67	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	1220	186	46	3H-5HT	-3235	44	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	186	46	3H-5HT	-3235	44	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	186	46	3H-5HT	-3235	44	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	186	46	3H-5HT	-3235	44	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	3337	214441	0	3H-5HT	-75	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	3337	214441	0	3H-LSD	-75	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	65801	214441	0	3H-5HT	-75	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	65801	214441	0	3H-LSD	-75	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	66264	214441	0	3H-5HT	-75	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	66264	214441	0	3H-LSD	-75	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	91452	214441	0	3H-5HT	-75	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	91452	214441	0	3H-LSD	-75	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	1210	905	45	3H-RAUWOLSCINE	-1380	20	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	1213	905	45	3H-RAUWOLSCINE	-1380	20	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	2725	905	45	3H-RAUWOLSCINE	-1380	20	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	33036	905	45	3H-RAUWOLSCINE	-1380	20	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	4411	905	45	3H-RAUWOLSCINE	-1380	20	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	616	905	45	3H-RAUWOLSCINE	-1380	20	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	6976	905	45	3H-RAUWOLSCINE	-1380	20	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	716121	905	45	3H-RAUWOLSCINE	-1380	20	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	90475904	905	45	3H-RAUWOLSCINE	-1380	20	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL1201353	905	45	3H-RAUWOLSCINE	-1380	20	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL1554789	905	45	3H-RAUWOLSCINE	-1380	20	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL505	905	45	3H-RAUWOLSCINE	-1380	20	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	DB01114	905	45	3H-RAUWOLSCINE	-1380	20	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	DB13679	905	45	3H-RAUWOLSCINE	-1380	20	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	102	4064	44	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4064	44	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4064	44	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4064	44	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4064	44	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	155	719	20	3H-5HT	-5	12	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	163	719	20	3H-5HT	-5	12	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	62065	719	20	3H-5HT	-5	12	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	CHEMBL6607	719	20	3H-5HT	-5	12	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	DB01484	719	20	3H-5HT	-5	12	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	102	4064	44	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4064	44	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4064	44	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4064	44	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4064	44	3H-5HT	-93	49	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	11954224	214174	0	3H-LSD	-66	59	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	11291	3169	23	3H-KETANSERIN	-44	4	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	None
	4980	3169	23	3H-KETANSERIN	-44	4	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	None
	CHEMBL65547	3169	23	3H-KETANSERIN	-44	4	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	None
	None	214703	0	3H-5HT	1	27	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
	173	3211	88	3H-KETANSERIN	-5	22	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	5011	3211	88	3H-KETANSERIN	-5	22	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	CHEMBL18772	3211	88	3H-KETANSERIN	-5	22	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	2181	3079	0	3H-5HT	-2	34	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	4830	3079	0	3H-5HT	-2	34	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	92	3079	0	3H-5HT	-2	34	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	CHEMBL440294	3079	0	3H-5HT	-2	34	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	DB09286	3079	0	3H-5HT	-2	34	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	15897	2817	0	3H-5-HT	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	15897	2817	0	3H-5HT	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2817	0	3H-5-HT	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2817	0	3H-5HT	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2817	0	3H-5-HT	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2817	0	3H-5HT	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	186	1777	47	3H-5HT	-616	16	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
	71781	1777	47	3H-5HT	-616	16	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
	CHEMBL18972	1777	47	3H-5HT	-616	16	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
	5268	3599	34	3H-5HT	-1047	17	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
	53	3599	34	3H-5HT	-1047	17	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
	CHEMBL300555	3599	34	3H-5HT	-1047	17	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
	15897	2817	0	3H-LSD	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2817	0	3H-LSD	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2817	0	3H-LSD	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	173	3211	88	3H-5HT	1	22	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	5011	3211	88	3H-5HT	1	22	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	CHEMBL18772	3211	88	3H-5HT	1	22	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	11653679	180609	1	UNDEFINED	-75	11	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	374	6	0	3	4.7	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	None
	CHEMBL476108	180609	1	UNDEFINED	-75	11	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	374	6	0	3	4.7	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	None
	10836	14329	13	None	-3	8	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	149	3	1	1	1.8	CN[C@@H](C)Cc1ccccc1	None
	CHEMBL1201201	14329	13	None	-3	8	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	149	3	1	1	1.8	CN[C@@H](C)Cc1ccccc1	None
	5475158	66877	20	3H-KETANSERIN	-1	13	Bovine	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	340	8	1	3	4.4	CN(C)CCCSc1ccccc1NC(=O)/C=C/c1ccccc1	None
	CHEMBL18786	66877	20	3H-KETANSERIN	-1	13	Bovine	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	340	8	1	3	4.4	CN(C)CCCSc1ccccc1NC(=O)/C=C/c1ccccc1	None
	5074	3280	75	3H-5HT	-3	29	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	5074	3280	75	3H-5HT	-9	29	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3280	75	3H-5HT	-3	29	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3280	75	3H-5HT	-9	29	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3280	75	3H-5HT	-3	29	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3280	75	3H-5HT	-9	29	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3280	75	3H-5HT	-3	29	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3280	75	3H-5HT	-9	29	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	5870	31445	85	None	-	1	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	270	0	1	2	3.8	C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CCC2=O	None
	CHEMBL1405	31445	85	None	-	1	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	270	0	1	2	3.8	C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CCC2=O	None
	None	214630	0	3H-5HT	5	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	342	4	3	4	2.5	CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N.C(=CC(=O)O)C(=O)O	None
	5074	3280	75	3H-5HT	-9	29	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3280	75	3H-5HT	-9	29	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3280	75	3H-5HT	-9	29	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3280	75	3H-5HT	-9	29	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	2812	4711	96	None	-40	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
	CHEMBL104	4711	96	None	-40	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
	222757	98917	70	None	-1	3	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	376	2	1	3	5.1	C[C@]12CC[C@@H]3c4ccc(OC(=O)c5ccccc5)cc4CC[C@H]3[C@@H]1CC[C@@H]2O	None
	CHEMBL282575	98917	70	None	-1	3	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	376	2	1	3	5.1	C[C@]12CC[C@@H]3c4ccc(OC(=O)c5ccccc5)cc4CC[C@H]3[C@@H]1CC[C@@H]2O	None
	1210	905	45	None	-1380	20	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	1213	905	45	None	-1380	20	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	2725	905	45	None	-1380	20	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	33036	905	45	None	-1380	20	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	4411	905	45	None	-1380	20	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	616	905	45	None	-1380	20	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	6976	905	45	None	-1380	20	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	716121	905	45	None	-1380	20	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	90475904	905	45	None	-1380	20	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL1201353	905	45	None	-1380	20	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL1554789	905	45	None	-1380	20	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL505	905	45	None	-1380	20	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	DB01114	905	45	None	-1380	20	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	DB13679	905	45	None	-1380	20	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	5074	3280	75	3H-5HT	-9	29	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3280	75	3H-5HT	-9	29	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3280	75	3H-5HT	-9	29	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3280	75	3H-5HT	-9	29	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	1357	2450	133	None	-3890	8	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2450	133	None	-3890	8	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2450	133	None	-3890	8	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2450	133	None	-3890	8	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2450	133	None	-3890	8	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2450	133	None	-3890	8	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1342	36	42	3H-5HT	-4	18	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3	36	42	3H-5HT	-4	18	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	CHEMBL277120	36	42	3H-5HT	-4	18	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	1209	1628	69	None	-199	31	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	203	1628	69	None	-199	31	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	3386	1628	69	None	-199	31	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	CHEMBL41	1628	69	None	-199	31	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	DB00472	1628	69	None	-199	31	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	3198	203802	73	None	-30	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
	CHEMBL1201049	203802	73	None	-30	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
	CHEMBL808	203802	73	None	-30	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
	2406	99938	84	None	-27	12	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	None
	CHEMBL290106	99938	84	None	-27	12	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	None
	None	214630	0	3H-5HT	5	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	342	4	3	4	2.5	CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N.C(=CC(=O)O)C(=O)O	None
	66265	93579	12	None	-1	19	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL248702	93579	12	None	-1	19	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1	None
	1836	2554	56	None	-69	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
	3340	2554	56	None	-69	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
	5281040	2554	56	None	-69	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
	CHEMBL787	2554	56	None	-69	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
	DB00471	2554	56	None	-69	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
	2402	3318	58	None	-9	25	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	5095	3318	58	None	-9	25	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	7295	3318	58	None	-9	25	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	CHEMBL589	3318	58	None	-9	25	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	DB00268	3318	58	None	-9	25	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	3598	187238	73	None	-2	7	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	None
	CHEMBL496	187238	73	None	-2	7	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	None
	135	2496	38	3H-RAUWOLSCINE	-3	57	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2496	38	3H-RAUWOLSCINE	-3	57	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2496	38	3H-RAUWOLSCINE	-3	57	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2496	38	3H-RAUWOLSCINE	-3	57	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2496	38	3H-RAUWOLSCINE	-3	57	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4189	205195	91	None	-26	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	CHEMBL1559	205195	91	None	-26	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	CHEMBL91	205195	91	None	-26	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	4943	192814	100	None	1	2	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	178	2	1	1	3.6	CC(C)c1cccc(C(C)C)c1O	None
	CHEMBL526	192814	100	None	1	2	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	178	2	1	1	3.6	CC(C)c1cccc(C(C)C)c1O	None
	3336	94560	27	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	None
	CHEMBL1405922	94560	27	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	None
	CHEMBL254832	94560	27	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	None
	135	2496	38	3H-MESULERGINE	-3	57	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2496	38	3H-MESULERGINE	-3	57	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2496	38	3H-MESULERGINE	-3	57	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2496	38	3H-MESULERGINE	-3	57	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2496	38	3H-MESULERGINE	-3	57	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	189	3436	31	3H-MESULERGINE	-5	17	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	5163	3436	31	3H-MESULERGINE	-5	17	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	CHEMBL297784	3436	31	3H-MESULERGINE	-5	17	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	4211	57517	81	None	-2	4	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	None
	CHEMBL1670	57517	81	None	-2	4	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	None
	5353853	17803	41	None	-23	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	9556529	17803	41	None	-23	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	CHEMBL1262	17803	41	None	-23	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	1599	2309	47	None	-144	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	None
	3955	2309	47	None	-144	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	None
	7215	2309	47	None	-144	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	None
	CHEMBL841	2309	47	None	-144	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	None
	DB00836	2309	47	None	-144	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	None
	4209	3114	71	None	-758	33	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	4893	3114	71	None	-758	33	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	503	3114	71	None	-758	33	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	5385	3114	71	None	-758	33	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	CHEMBL2	3114	71	None	-758	33	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	DB00457	3114	71	None	-758	33	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	2142	3047	54	None	-43	36	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	4920903	3047	54	None	-43	36	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	502	3047	54	None	-43	36	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	5775	3047	54	None	-43	36	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	CHEMBL597	3047	54	None	-43	36	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	DB00692	3047	54	None	-43	36	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	146	135	80	3H-5HT	1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	178	2	2	1	1.8	NCCc1c[nH]c2c1cc(F)cc2	None
	164682	135	80	3H-5HT	1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	178	2	2	1	1.8	NCCc1c[nH]c2c1cc(F)cc2	None
	CHEMBL275628	135	80	3H-5HT	1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	178	2	2	1	1.8	NCCc1c[nH]c2c1cc(F)cc2	None
	68617	203816	60	None	-15	25	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
	CHEMBL1709	203816	60	None	-15	25	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
	CHEMBL809	203816	60	None	-15	25	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
	4601	205020	29	None	-4	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
	CHEMBL1201023	205020	29	None	-4	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
	CHEMBL900	205020	29	None	-4	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
	448537	159703	86	None	-21	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	None
	CHEMBL411	159703	86	None	-21	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	None
	2176	3077	66	None	-933	26	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	4828	3077	66	None	-933	26	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	91	3077	66	None	-933	26	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	CHEMBL500	3077	66	None	-933	26	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	DB00960	3077	66	None	-933	26	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	1531	2235	64	None	-16	14	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	None
	3869	2235	64	None	-16	14	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	None
	7207	2235	64	None	-16	14	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	None
	CHEMBL429	2235	64	None	-16	14	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	None
	DB00598	2235	64	None	-16	14	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	None
	5318	15400	44	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
	CHEMBL1200348	15400	44	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
	CHEMBL1221	15400	44	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
	119607	214647	0	None	97	28	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	3	1	4	3.0	CC1=C(C(=NO1)C2=CC=CC=C2)C3=CC=C(C=C3)S(=O)(=O)N	None
	1227	2454	35	None	-112	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
	2331	2454	35	None	-112	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
	3957	2454	35	None	-112	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
	4992	2454	35	None	-112	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
	CHEMBL511	2454	35	None	-112	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
	DB06691	2454	35	None	-112	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
	3151	1434	93	None	-125	26	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
	945	1434	93	None	-125	26	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
	965	1434	93	None	-125	26	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
	CHEMBL219916	1434	93	None	-125	26	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
	DB01184	1434	93	None	-125	26	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
	1343	1858	55	None	-14	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
	3519	1858	55	None	-14	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
	522	1858	55	None	-14	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
	CHEMBL862	1858	55	None	-14	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
	DB01018	1858	55	None	-14	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
	1016	3690	75	None	-17	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	2561	3690	75	None	-17	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	2733526	3690	75	None	-17	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	5384	3690	75	None	-17	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	CHEMBL83	3690	75	None	-17	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	DB00675	3690	75	None	-17	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	5510	204137	97	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	307	2	0	2	4.9	Cc1cccc(N(C)C(=S)Oc2ccc3ccccc3c2)c1	None
	CHEMBL83668	204137	97	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	307	2	0	2	4.9	Cc1cccc(N(C)C(=S)Oc2ccc3ccccc3c2)c1	None
	2202	3083	91	None	-6	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
	4850	3083	91	None	-6	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
	49	3083	91	None	-6	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
	CHEMBL1371770	3083	91	None	-6	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
	DB12478	3083	91	None	-6	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
	2723	153512	104	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	156	0	1	1	2.7	Cc1cc(O)cc(C)c1Cl	None
	CHEMBL398440	153512	104	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	156	0	1	1	2.7	Cc1cc(O)cc(C)c1Cl	None
	2771	193347	67	None	1	26	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
	CHEMBL1200781	193347	67	None	1	26	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
	CHEMBL549	193347	67	None	1	26	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
	2333	141803	91	None	1	2	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	None
	CHEMBL388590	141803	91	None	1	2	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	None
	135	2496	38	3H-5HT	-37	57	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2496	38	3H-5HT	-37	57	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2496	38	3H-5HT	-37	57	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2496	38	3H-5HT	-37	57	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2496	38	3H-5HT	-37	57	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	2470	3596	46	125I-DOI	-1513	59	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3596	46	125I-DOI	-1513	59	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3596	46	125I-DOI	-1513	59	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3596	46	125I-DOI	-1513	59	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3596	46	125I-DOI	-1513	59	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	102	4064	44	3H-5HT	-93	49	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	102	4064	44	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4064	44	3H-5HT	-93	49	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4064	44	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4064	44	3H-5HT	-93	49	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4064	44	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4064	44	3H-5HT	-93	49	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4064	44	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4064	44	3H-5HT	-93	49	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4064	44	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	135	2496	38	3H-5HT	-37	57	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2496	38	3H-5HT	-37	57	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2496	38	3H-5HT	-37	57	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2496	38	3H-5HT	-37	57	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2496	38	3H-5HT	-37	57	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	221	3435	63	UNDEFINED	4	13	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	3277600	3435	63	UNDEFINED	4	13	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	CHEMBL323356	3435	63	UNDEFINED	4	13	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	102	4064	44	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4064	44	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4064	44	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4064	44	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4064	44	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	1615	167228	22	3H-LSD	-2	44	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
	CHEMBL43048	167228	22	3H-LSD	-2	44	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
	122	1409	9	3H-5HT	-100	10	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
	156314	1409	9	3H-5HT	-100	10	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL1332062	1409	9	3H-5HT	-100	10	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
	1209	1628	69	3H-5HT	-199	31	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	203	1628	69	3H-5HT	-199	31	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	3386	1628	69	3H-5HT	-199	31	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	CHEMBL41	1628	69	3H-5HT	-199	31	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	DB00472	1628	69	3H-5HT	-199	31	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	5268	3599	34	3H-5HT	-1047	17	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
	53	3599	34	3H-5HT	-1047	17	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
	CHEMBL300555	3599	34	3H-5HT	-1047	17	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
	208	2820	0	3H-5HT	-69	12	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	4541	2820	0	3H-5HT	-69	12	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	CHEMBL1494	2820	0	3H-5HT	-69	12	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	3337	214441	0	3H-5-HT	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	3337	214441	0	3H-5HT	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	65801	214441	0	3H-5-HT	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	65801	214441	0	3H-5HT	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	66264	214441	0	3H-5-HT	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	66264	214441	0	3H-5HT	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	91452	214441	0	3H-5-HT	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	91452	214441	0	3H-5HT	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	221	3435	63	3H-MESULERGINE	-4	13	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	3277600	3435	63	3H-MESULERGINE	-4	13	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	CHEMBL323356	3435	63	3H-MESULERGINE	-4	13	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	3337	214441	0	3H-LSD	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	65801	214441	0	3H-LSD	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	66264	214441	0	3H-LSD	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	91452	214441	0	3H-LSD	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	108182	4068	18	3H-5HT	-1	16	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	245	4068	18	3H-5HT	-1	16	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	CHEMBL18041	4068	18	3H-5HT	-1	16	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	15897	2817	0	3H-LSD	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2817	0	3H-LSD	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2817	0	3H-LSD	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	15897	2817	0	3H-5HT	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2817	0	3H-5HT	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2817	0	3H-5HT	12	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	135	2496	38	3H-5HT	-37	57	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2496	38	3H-5HT	-37	57	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2496	38	3H-5HT	-37	57	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2496	38	3H-5HT	-37	57	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2496	38	3H-5HT	-37	57	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	135	2496	38	3H-5HT	-37	57	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2496	38	3H-5HT	-37	57	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2496	38	3H-5HT	-37	57	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2496	38	3H-5HT	-37	57	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2496	38	3H-5HT	-37	57	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	None	214255	0	3H-5HT	-5	4	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase		None	None	None		None	None
	2105	3005	34	Functional	-28	33	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	47811	3005	34	Functional	-28	33	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	48	3005	34	Functional	-28	33	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	CHEMBL531	3005	34	Functional	-28	33	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	DB01186	3005	34	Functional	-28	33	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	102	4064	44	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4064	44	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4064	44	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4064	44	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4064	44	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	135398745	2869	108	3H-5HT	-27	65	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2869	108	3H-5HT	-27	65	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2869	108	3H-5HT	-27	65	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2869	108	3H-5HT	-27	65	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	11957541	1430	38	3H-5HT	-1	15	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	1229	1430	38	3H-5HT	-1	15	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	147	1430	38	3H-5HT	-1	15	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	170617	1430	38	3H-5HT	-1	15	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	CHEMBL6616	1430	38	3H-5HT	-1	15	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	102	4064	44	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4064	44	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4064	44	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4064	44	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4064	44	3H-5HT	-100	49	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	542051	204380	4	3H-5HT	-61	7	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	237	6	1	3	2.5	CCCc1cc(OC)c(CC(C)N)cc1OC	None
	CHEMBL8569	204380	4	3H-5HT	-61	7	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	237	6	1	3	2.5	CCCc1cc(OC)c(CC(C)N)cc1OC	None
	1220	186	46	3H-KETANSERIN	-4265	44	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	186	46	3H-KETANSERIN	-4265	44	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	186	46	3H-KETANSERIN	-4265	44	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	186	46	3H-KETANSERIN	-4265	44	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	3337	214441	0	3H-5HT	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	65801	214441	0	3H-5HT	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	66264	214441	0	3H-5HT	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	91452	214441	0	3H-5HT	-75	40	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	11957541	1430	38	3H-KETANSERIN	-13	15	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	1229	1430	38	3H-KETANSERIN	-13	15	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	147	1430	38	3H-KETANSERIN	-13	15	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	170617	1430	38	3H-KETANSERIN	-13	15	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	CHEMBL6616	1430	38	3H-KETANSERIN	-13	15	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	141	1399	32	3H-KETANSERIN	-6	21	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	6089	1399	32	3H-KETANSERIN	-6	21	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	CHEMBL12420	1399	32	3H-KETANSERIN	-6	21	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	DB01488	1399	32	3H-KETANSERIN	-6	21	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	31101	720	39	3H-MESULERGINE	-26	35	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	35	720	39	3H-MESULERGINE	-26	35	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	403	720	39	3H-MESULERGINE	-26	35	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	CHEMBL493	720	39	3H-MESULERGINE	-26	35	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	DB01200	720	39	3H-MESULERGINE	-26	35	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	2181	3079	0	3H-5HT	-91	34	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	4830	3079	0	3H-5HT	-91	34	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	92	3079	0	3H-5HT	-91	34	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	CHEMBL440294	3079	0	3H-5HT	-91	34	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	DB09286	3079	0	3H-5HT	-91	34	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	3337	214441	0	3H-5-HT	-75	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	3337	214441	0	3H-5HT	-75	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	3337	214441	0	3H-LSD	-75	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	65801	214441	0	3H-5-HT	-75	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	65801	214441	0	3H-5HT	-75	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	65801	214441	0	3H-LSD	-75	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	66264	214441	0	3H-5-HT	-75	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	66264	214441	0	3H-5HT	-75	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	66264	214441	0	3H-LSD	-75	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	91452	214441	0	3H-5-HT	-75	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	91452	214441	0	3H-5HT	-75	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	91452	214441	0	3H-LSD	-75	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	1357	2450	133	3H-MESULERGINE	-3890	8	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2450	133	3H-MESULERGINE	-3890	8	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2450	133	3H-MESULERGINE	-3890	8	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2450	133	3H-MESULERGINE	-3890	8	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2450	133	3H-MESULERGINE	-3890	8	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2450	133	3H-MESULERGINE	-3890	8	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	115	3732	78	3H-5HT	-1	26	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	4296	3732	78	3H-5HT	-1	26	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	CHEMBL274866	3732	78	3H-5HT	-1	26	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	138107169	214173	0	3H-5HT	-117	22	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	22831402	214173	0	3H-5HT	-117	22	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	2470	3596	46	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3596	46	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3596	46	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3596	46	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3596	46	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	283	3081	47	3H-5HT	-562	12	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
	4847	3081	47	3H-5HT	-562	12	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
	CHEMBL18331	3081	47	3H-5HT	-562	12	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
	2726	906	64	3H-KETANSERIN	-3	72	Bovine	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	906	64	3H-KETANSERIN	-3	72	Bovine	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	906	64	3H-KETANSERIN	-3	72	Bovine	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	906	64	3H-KETANSERIN	-3	72	Bovine	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	906	64	3H-KETANSERIN	-3	72	Bovine	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	None	215731	0	UNDEFINED	-14	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	421	4	3	4	3.3	C1CC2=C(CC1CNCC3COC4=C(O3)C=CC5=C4CC(=O)N5)C6=C(N2)C=CC(=C6)F	None
	44112	120777	41	None	-11	7	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	None
	CHEMBL357995	120777	41	None	-11	7	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	None
	1548955	88153	17	None	-1	18	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
	2800	88153	17	None	-1	18	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
	CHEMBL2355051	88153	17	None	-1	18	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
	3168	9172	84	None	-107	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	None
	CHEMBL1108	9172	84	None	-107	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	None
	3042	1386	31	None	-39	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	355	1386	31	None	-39	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	868	1386	31	None	-39	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	CHEMBL1123	1386	31	None	-39	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	DB00804	1386	31	None	-39	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	5591	156989	84	None	1	2	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	None
	CHEMBL408	156989	84	None	1	2	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	None
	1353	1880	85	None	-295	85	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1880	85	None	-295	85	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1880	85	None	-295	85	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1880	85	None	-295	85	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1880	85	None	-295	85	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	4452	2721	18	3H-LSD	-208	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
	983	2721	18	3H-LSD	-208	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
	CHEMBL20734	2721	18	3H-LSD	-208	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
	4178	194130	58	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	179	3	1	2	2.0	Cc1cccc(C)c1OCC(C)N	None
	CHEMBL558	194130	58	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	179	3	1	2	2.0	Cc1cccc(C)c1OCC(C)N	None
	1224	1404	79	None	-6	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	3100	1404	79	None	-6	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	8980	1404	79	None	-6	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	916	1404	79	None	-6	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	CHEMBL657	1404	79	None	-6	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	DB01075	1404	79	None	-6	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	146159245	187866	27	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	None
	451415	187866	27	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	None
	86289437	187866	27	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	None
	CHEMBL502620	187866	27	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	None
	12488	1627	51	None	-11	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
	941361	1627	51	None	-11	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
	CHEMBL30008	1627	51	None	-11	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
	DB04841	1627	51	None	-11	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
	3033538	1292	36	None	-12	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	None
	7155	1292	36	None	-12	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	None
	781	1292	36	None	-12	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	None
	CHEMBL1201216	1292	36	None	-12	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	None
	DB00298	1292	36	None	-12	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	None
	77379	18856	66	3H-5HT	2	2	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	194	2	2	1	2.3	NCCc1c[nH]c2ccc(Cl)cc12	None
	CHEMBL1288716	18856	66	3H-5HT	2	2	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	194	2	2	1	2.3	NCCc1c[nH]c2ccc(Cl)cc12	None
	657255	197406	29	None	-9	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	None
	CHEMBL588119	197406	29	None	-9	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	None
	176	394	63	None	-1	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	2157	394	63	None	-1	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	2566	394	63	None	-1	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	CHEMBL633	394	63	None	-1	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	DB01118	394	63	None	-1	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	4098	32289	24	None	-14	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
	CHEMBL1255739	32289	24	None	-14	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
	CHEMBL1411979	32289	24	None	-14	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
	5282379	193314	64	None	1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C\C(=O)O)C(C)(C)CCC1	None
	CHEMBL547	193314	64	None	1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C\C(=O)O)C(C)(C)CCC1	None
	134	2478	19	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2478	19	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2478	19	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2478	19	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2478	19	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	2028	2931	77	None	-40	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	359	2931	77	None	-40	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	4634	2931	77	None	-40	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	CHEMBL1231	2931	77	None	-40	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	DB01062	2931	77	None	-40	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	134	2478	19	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2478	19	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2478	19	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2478	19	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2478	19	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	134	2478	19	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2478	19	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2478	19	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2478	19	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2478	19	3H-5HT	-12	67	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	6437377	214175	0	3H-5HT	-5	4	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	500	6	3	7	3.2	CC(C)N1C=C2CC3C(CC(CN3C)C(=O)OC(C)C(C)O)C4=C2C1=CC=C4.C(=CC(=O)O)C(=O)O	None
	1547484	927	70	None	-8	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	654	927	70	None	-8	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	9072	927	70	None	-8	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	CHEMBL43064	927	70	None	-8	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	DB00568	927	70	None	-8	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	4595	176141	102	None	2	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
	CHEMBL46	176141	102	None	2	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
	1782	2482	81	None	-3	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
	241	2482	81	None	-3	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
	4168	2482	81	None	-3	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
	CHEMBL86	2482	81	None	-3	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
	DB01233	2482	81	None	-3	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
	2477	734	54	None	-13	28	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	36	734	54	None	-13	28	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	437	734	54	None	-13	28	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	CHEMBL49	734	54	None	-13	28	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	DB00490	734	54	None	-13	28	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	5074	3280	75	3H-5HT	-3	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3280	75	3H-5HT	-3	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3280	75	3H-5HT	-3	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3280	75	3H-5HT	-3	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	6075	149575	36	None	-8	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	None
	CHEMBL395110	149575	36	None	-8	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	None
	2470	3596	46	None	-14125	59	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3596	46	None	-14125	59	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3596	46	None	-14125	59	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3596	46	None	-14125	59	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3596	46	None	-14125	59	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	198	310	120	None	-346	5	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	82148	310	120	None	-346	5	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	99	310	120	None	-346	5	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	CHEMBL10878	310	120	None	-346	5	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	DB06594	310	120	None	-346	5	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	210	3421	0	None	-7	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	None
	2423	3421	0	None	-7	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	None
	5160	3421	0	None	-7	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	None
	CHEMBL52939	3421	0	None	-7	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	None
	DB12163	3421	0	None	-7	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	None
	133	2460	48	3H-5HT	-12	42	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2460	48	3H-5HT	-12	42	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2460	48	3H-5HT	-12	42	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2460	48	3H-5HT	-12	42	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2460	48	3H-5HT	-12	42	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	6726	1254	46	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	7151	1254	46	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	749	1254	46	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	CHEMBL648	1254	46	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	DB01176	1254	46	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	3157	1442	69	None	-37	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	None
	7170	1442	69	None	-37	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	None
	954	1442	69	None	-37	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	None
	CHEMBL707	1442	69	None	-37	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	None
	DB00590	1442	69	None	-37	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	None
	444795	139469	102	None	3	2	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1	None
	CHEMBL38	139469	102	None	3	2	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1	None
	2284	3133	27	None	-16	28	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	4926	3133	27	None	-16	28	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	7281	3133	27	None	-16	28	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	CHEMBL564	3133	27	None	-16	28	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	DB00420	3133	27	None	-16	28	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	165193	3138	60	None	-72	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	2303	3138	60	None	-72	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	4946	3138	60	None	-72	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	564	3138	60	None	-72	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	62882	3138	60	None	-72	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	63	3138	60	None	-72	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	66366	3138	60	None	-72	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	91536	3138	60	None	-72	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	CHEMBL27	3138	60	None	-72	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	CHEMBL452861	3138	60	None	-72	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	DB00571	3138	60	None	-72	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	4011	81996	43	None	-20	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
	CHEMBL21731	81996	43	None	-20	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
	3191	102385	93	None	-7	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
	CHEMBL305660	102385	93	None	-7	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
	1524	2150	89	None	-218	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2150	89	None	-218	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2150	89	None	-218	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2150	89	None	-218	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2150	89	None	-218	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2150	89	None	-218	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	119584	2557	99	None	1	6	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	None
	1848	2557	99	None	1	6	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	None
	242	2557	99	None	1	6	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	None
	CHEMBL60889	2557	99	None	1	6	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	None
	DB11675	2557	99	None	1	6	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	None
	33630	178379	94	None	-6	27	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	Drug Central	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
	CHEMBL47050	178379	94	None	-6	27	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	Drug Central	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
	1605	2310	110	None	-1	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
	3957	2310	110	None	-1	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
	7216	2310	110	None	-1	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
	CHEMBL998	2310	110	None	-1	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
	DB00455	2310	110	None	-1	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
	2895	201898	35	None	1	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	None
	CHEMBL669	201898	35	None	1	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	None
	2801	161325	56	None	-3	28	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	314	4	0	2	4.5	CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21	None
	CHEMBL1200710	161325	56	None	-3	28	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	314	4	0	2	4.5	CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21	None
	CHEMBL415	161325	56	None	-3	28	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	314	4	0	2	4.5	CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21	None
	1222	1634	44	None	-52	32	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3396	1634	44	None	-52	32	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	85	1634	44	None	-52	32	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL46516	1634	44	None	-52	32	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	DB04842	1634	44	None	-52	32	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	11658860	2312	47	None	-1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	None
	2941	2312	47	None	-1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	None
	4374	2312	47	None	-1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	None
	CHEMBL360328	2312	47	None	-1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	None
	DB04871	2312	47	None	-1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	None
	124	2933	44	None	-181	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
	2032	2933	44	None	-181	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
	4636	2933	44	None	-181	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
	CHEMBL762	2933	44	None	-181	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
	DB00935	2933	44	None	-181	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
	6437377	214175	0	3H-5HT	-5	4	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	500	6	3	7	3.2	CC(C)N1C=C2CC3C(CC(CN3C)C(=O)OC(C)C(C)O)C4=C2C1=CC=C4.C(=CC(=O)O)C(=O)O	None
	1201549	590	22	None	-26	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	333	590	22	None	-26	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	7601	590	22	None	-26	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	CHEMBL1201203	590	22	None	-26	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	CHEMBL438151	590	22	None	-26	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	DB00245	590	22	None	-26	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	228	441	26	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	33	441	26	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	6005	441	26	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	CHEMBL53	441	26	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	DB00714	441	26	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	152	361	18	3H-5HT	1	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	2107	361	18	3H-5HT	1	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	CHEMBL275854	361	18	3H-5HT	1	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	2520	202310	65	None	-4	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
	CHEMBL1280	202310	65	None	-4	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
	CHEMBL6966	202310	65	None	-4	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
	15897	2817	0	Functional	12	36	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2817	0	Functional	12	36	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2817	0	Functional	12	36	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	None	214162	0	3H-KETANSERIN	-3	5	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	6	2	7	2.1	CC(C1=CC=CC2=NC3=C(C=CC=C3N=C21)C(=O)O)OC(=O)C(CO)OC	None
	10624	69957	17	3H-KETANSERIN	-6	32	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
	138543650	69957	17	3H-KETANSERIN	-6	32	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
	CHEMBL194378	69957	17	3H-KETANSERIN	-6	32	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
	71285	214207	0	Functional	-	1	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	209	3	2	4	1.3	CC(CC1=CC2=C(C=C1O)OCO2)NC	None
	283	3081	47	3H-5HT	-57	12	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
	4847	3081	47	3H-5HT	-57	12	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
	CHEMBL18331	3081	47	3H-5HT	-57	12	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
	115237	55296	113	3H-LSD	-16	54	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	CHEMBL1621	55296	113	3H-LSD	-16	54	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	None	215730	0	UNDEFINED	-83	3	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	449	6	3	4	4.1	C1CC2=C(CC1CCCNCC3COC4=C(O3)C=CC5=C4CC(=O)N5)NC6=C2C=C(C=C6)F	None
	107992	2516	47	3H-5HT	-1	9	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	165	2516	47	3H-5HT	-1	9	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	CHEMBL269521	2516	47	3H-5HT	-1	9	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	DB12111	2516	47	3H-5HT	-1	9	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	240	931	39	3H-5HT	-6	25	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	2769	931	39	3H-5HT	-6	25	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	44279790	931	39	3H-5HT	-6	25	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	660	931	39	3H-5HT	-6	25	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL1729	931	39	3H-5HT	-6	25	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL560739	931	39	3H-5HT	-6	25	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	DB00604	931	39	3H-5HT	-6	25	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	7153	97570	74	Functional	-1	33	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97570	74	Functional	-1	33	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	None	214703	0	Functional	1	27	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
	107780	1814	50	3H-5HT	-676	17	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	14	1814	50	3H-5HT	-676	17	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	CHEMBL15928	1814	50	3H-5HT	-676	17	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	1524	2150	89	3H-5HT	-218	51	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2150	89	3H-5HT	-218	51	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2150	89	3H-5HT	-218	51	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2150	89	3H-5HT	-218	51	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2150	89	3H-5HT	-218	51	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2150	89	3H-5HT	-218	51	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	1524	2150	89	3H-5HT	-218	51	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2150	89	3H-5HT	-218	51	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2150	89	3H-5HT	-218	51	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2150	89	3H-5HT	-218	51	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2150	89	3H-5HT	-218	51	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2150	89	3H-5HT	-218	51	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	173	3211	88	3H-5HT	-3	22	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	5011	3211	88	3H-5HT	-3	22	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	CHEMBL18772	3211	88	3H-5HT	-3	22	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	1574	81	52	125I-DOI	-70	20	Mouse	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	218	81	52	125I-DOI	-70	20	Mouse	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	CHEMBL266591	81	52	125I-DOI	-70	20	Mouse	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	173	3211	88	125I-DOI	-75	22	Mouse	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	5011	3211	88	125I-DOI	-75	22	Mouse	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	CHEMBL18772	3211	88	125I-DOI	-75	22	Mouse	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	1342	36	42	3H-5HT	-4	18	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3	36	42	3H-5HT	-4	18	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	CHEMBL277120	36	42	3H-5HT	-4	18	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	44626329	195732	0	UNDEFINED	-20	3	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	420	3	2	4	3.7	O=c1[nH]c2cccc(N3CCN(CC4CCc5[nH]c6ccc(F)cc6c5C4)CC3)c2o1	None
	CHEMBL569513	195732	0	UNDEFINED	-20	3	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	420	3	2	4	3.7	O=c1[nH]c2cccc(N3CCN(CC4CCc5[nH]c6ccc(F)cc6c5C4)CC3)c2o1	None
	3337	214441	0	3H-LSD	-75	40	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	65801	214441	0	3H-LSD	-75	40	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	66264	214441	0	3H-LSD	-75	40	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	91452	214441	0	3H-LSD	-75	40	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	1210	905	45	3H-5HT	-1380	20	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	1213	905	45	3H-5HT	-1380	20	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	2725	905	45	3H-5HT	-1380	20	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	33036	905	45	3H-5HT	-1380	20	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	4411	905	45	3H-5HT	-1380	20	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	616	905	45	3H-5HT	-1380	20	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	6976	905	45	3H-5HT	-1380	20	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	716121	905	45	3H-5HT	-1380	20	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	90475904	905	45	3H-5HT	-1380	20	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL1201353	905	45	3H-5HT	-1380	20	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL1554789	905	45	3H-5HT	-1380	20	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL505	905	45	3H-5HT	-1380	20	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	DB01114	905	45	3H-5HT	-1380	20	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	DB13679	905	45	3H-5HT	-1380	20	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	62787	204467	17	3H-KETANSERIN	-64	9	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	195	4	1	3	1.6	COc1ccc(OC)c(CC(C)N)c1	None
	CHEMBL8642	204467	17	3H-KETANSERIN	-64	9	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	195	4	1	3	1.6	COc1ccc(OC)c(CC(C)N)c1	None
	2470	3596	46	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3596	46	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3596	46	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3596	46	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3596	46	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	4976	201885	27	None	-1	11	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	None
	CHEMBL668	201885	27	None	-1	11	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	None
	5440	216001	0	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	399	6	0	5	5.0	CCSC1=CC=C2SC3=CC=CC=C3N(CCCN3CCN(C)CC3)C2=C1	None
	5022	1621	67	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	None
	6918248	1621	67	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	None
	8182	1621	67	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	None
	CHEMBL231068	1621	67	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	None
	DB04908	1621	67	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	None
	4543	169982	36	None	-3	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2ccccc21	None
	CHEMBL1201156	169982	36	None	-3	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2ccccc21	None
	CHEMBL445	169982	36	None	-3	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2ccccc21	None
	107	141	116	3H-5HT	-12	30	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	116	3H-5HT	-12	30	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	116	3H-5HT	-12	30	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	213	3792	50	None	-3	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	2717	3792	50	None	-3	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	5533	3792	50	None	-3	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	CHEMBL621	3792	50	None	-3	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	DB00656	3792	50	None	-3	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	11957541	1430	38	3H-MESULERGINE	-1	15	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	1229	1430	38	3H-MESULERGINE	-1	15	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	147	1430	38	3H-MESULERGINE	-1	15	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	170617	1430	38	3H-MESULERGINE	-1	15	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	CHEMBL6616	1430	38	3H-MESULERGINE	-1	15	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	2105	3005	34	3H-MESULERGINE	-28	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	47811	3005	34	3H-MESULERGINE	-28	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	48	3005	34	3H-MESULERGINE	-28	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	CHEMBL531	3005	34	3H-MESULERGINE	-28	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	DB01186	3005	34	3H-MESULERGINE	-28	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	2601	3721	30	3H-MESULERGINE	-8	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	443951	3721	30	3H-MESULERGINE	-8	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	56	3721	30	3H-MESULERGINE	-8	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL73151	3721	30	3H-MESULERGINE	-8	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB13399	3721	30	3H-MESULERGINE	-8	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	100	3745	52	None	-11	55	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3745	52	None	-11	55	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3745	52	None	-11	55	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3745	52	None	-11	55	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3745	52	None	-11	55	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	240	931	39	None	-6	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	2769	931	39	None	-6	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	44279790	931	39	None	-6	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	660	931	39	None	-6	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL1729	931	39	None	-6	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL560739	931	39	None	-6	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	DB00604	931	39	None	-6	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	135398737	944	89	3H-5HT	-2	91	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	944	89	3H-5HT	-2	91	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	944	89	3H-5HT	-2	91	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	944	89	3H-5HT	-2	91	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	944	89	3H-5HT	-2	91	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	2351	3234	60	None	-7	21	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
	2820	3234	60	None	-7	21	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
	5035	3234	60	None	-7	21	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
	CHEMBL81	3234	60	None	-7	21	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
	DB00481	3234	60	None	-7	21	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
	2274	3124	53	None	-10	32	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4917	3124	53	None	-10	32	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	7279	3124	53	None	-10	32	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL728	3124	53	None	-10	32	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00433	3124	53	None	-10	32	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	2099	9217	49	None	-	1	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	None
	CHEMBL1110	9217	49	None	-	1	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	None
	135398745	2869	108	3H-LSD	-5	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2869	108	3H-LSD	-5	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2869	108	3H-LSD	-5	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2869	108	3H-LSD	-5	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	3952	1857	33	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
	5353646	1857	33	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
	5443	1857	33	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
	5702063	1857	33	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
	CHEMBL1331786	1857	33	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
	CHEMBL420	1857	33	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
	115237	55296	113	None	-16	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	CHEMBL1621	55296	113	None	-16	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	2291	3135	52	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	None
	2561	3135	52	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	None
	4932	3135	52	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	None
	CHEMBL631	3135	52	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	None
	DB01182	3135	52	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	None
	216239	23591	114	None	2	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counter	Drug Central	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	None
	CHEMBL1200485	23591	114	None	2	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counter	Drug Central	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	None
	CHEMBL1336	23591	114	None	2	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counter	Drug Central	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	None
	2726	906	64	None	-19	72	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	906	64	None	-19	72	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	906	64	None	-19	72	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	906	64	None	-19	72	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	906	64	None	-19	72	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	31101	720	39	None	-26	35	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	35	720	39	None	-26	35	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	403	720	39	None	-26	35	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	CHEMBL493	720	39	None	-26	35	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	DB01200	720	39	None	-26	35	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	102	4064	44	None	-100	49	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4064	44	None	-100	49	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4064	44	None	-100	49	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4064	44	None	-100	49	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4064	44	None	-100	49	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	2181	3079	0	None	-2	34	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	4830	3079	0	None	-2	34	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	92	3079	0	None	-2	34	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	CHEMBL440294	3079	0	None	-2	34	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	DB09286	3079	0	None	-2	34	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	2286	3134	48	None	-5	29	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	4927	3134	48	None	-5	29	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	7282	3134	48	None	-5	29	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	CHEMBL643	3134	48	None	-5	29	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	DB01069	3134	48	None	-5	29	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	180	397	50	None	-35	38	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	200	397	50	None	-35	38	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	2160	397	50	None	-35	38	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL629	397	50	None	-35	38	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	DB00321	397	50	None	-35	38	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	2389	3279	114	None	-63	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3279	114	None	-63	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3279	114	None	-63	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3279	114	None	-63	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3279	114	None	-63	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	114948	216017	0	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Biased for β-arrestin signalling.Biased for β-arrestin signalling.	Drug Central	577	5	3	6	2.5	CC(C)C[C@@H]1N2C(=O)[C@](NC(=O)[C@@H]3C[C@H]4[C@@H](CC5=CNC6=CC=CC4=C56)N(C)C3)(O[C@@]2(O)[C@@H]2CCCN2C1=O)C(C)C	None
	6761	67457	17	None	-7	18	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	None
	CHEMBL1909072	67457	17	None	-7	18	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	None
	1621	2396	16	None	-19	44	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2396	16	None	-19	44	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2396	16	None	-19	44	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2396	16	None	-19	44	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2396	16	None	-19	44	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	2600	3720	73	None	-1	13	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
	2608	3720	73	None	-1	13	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
	5405	3720	73	None	-1	13	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
	CHEMBL17157	3720	73	None	-1	13	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
	DB00342	3720	73	None	-1	13	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
	1530	2151	44	None	-19	20	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
	3827	2151	44	None	-19	20	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
	7206	2151	44	None	-19	20	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
	CHEMBL534	2151	44	None	-19	20	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
	DB00920	2151	44	None	-19	20	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
	124087	1362	106	None	-5	15	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
	7157	1362	106	None	-5	15	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
	814	1362	106	None	-5	15	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
	CHEMBL1172	1362	106	None	-5	15	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
	DB00967	1362	106	None	-5	15	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
	2865	4079	67	None	-12	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4079	67	None	-12	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4079	67	None	-12	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4079	67	None	-12	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4079	67	None	-12	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	135398737	944	89	3H-5HT	-2	91	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	944	89	3H-5HT	-2	91	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	944	89	3H-5HT	-2	91	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	944	89	3H-5HT	-2	91	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	944	89	3H-5HT	-2	91	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	1212	1632	45	None	-27	65	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1632	45	None	-27	65	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1632	45	None	-27	65	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1632	45	None	-27	65	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1632	45	None	-27	65	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	26987	936	29	None	-47	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
	6063	936	29	None	-47	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
	671	936	29	None	-47	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
	CHEMBL1626	936	29	None	-47	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
	DB00283	936	29	None	-47	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
	2267	553	64	None	-10	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	Drug Central	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	None
	271	553	64	None	-10	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	Drug Central	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	None
	7121	553	64	None	-10	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	Drug Central	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	None
	CHEMBL639	553	64	None	-10	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	Drug Central	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	None
	DB00972	553	64	None	-10	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	Drug Central	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	None
	3652	4034	72	None	-2	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	57	4034	72	None	-2	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	60809	4034	72	None	-2	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	CHEMBL21536	4034	72	None	-2	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	DB15357	4034	72	None	-2	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	2585	790	100	None	-18	22	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
	522	790	100	None	-18	22	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
	551	790	100	None	-18	22	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
	CHEMBL723	790	100	None	-18	22	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
	DB01136	790	100	None	-18	22	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
	102	4064	44	None	-93	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4064	44	None	-93	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4064	44	None	-93	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4064	44	None	-93	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4064	44	None	-93	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	135398745	2869	108	None	-5	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2869	108	None	-5	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2869	108	None	-5	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2869	108	None	-5	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	134	2478	19	3H-5HT	-2	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2478	19	3H-5HT	-2	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2478	19	3H-5HT	-2	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2478	19	3H-5HT	-2	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2478	19	3H-5HT	-2	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	3036864	201066	16	Functional	-295	27	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1256645	201066	16	Functional	-295	27	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1814790	201066	16	Functional	-295	27	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL62	201066	16	Functional	-295	27	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	1615	167228	22	3H-LSD	-2	44	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
	CHEMBL43048	167228	22	3H-LSD	-2	44	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
	2470	3596	46	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3596	46	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3596	46	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3596	46	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3596	46	3H-5HT	-14125	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	1210	905	45	3H-5HT	-1380	20	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	1213	905	45	3H-5HT	-1380	20	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	2725	905	45	3H-5HT	-1380	20	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	33036	905	45	3H-5HT	-1380	20	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	4411	905	45	3H-5HT	-1380	20	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	616	905	45	3H-5HT	-1380	20	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	6976	905	45	3H-5HT	-1380	20	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	716121	905	45	3H-5HT	-1380	20	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	90475904	905	45	3H-5HT	-1380	20	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL1201353	905	45	3H-5HT	-1380	20	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL1554789	905	45	3H-5HT	-1380	20	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL505	905	45	3H-5HT	-1380	20	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	DB01114	905	45	3H-5HT	-1380	20	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	DB13679	905	45	3H-5HT	-1380	20	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	1150	3817	116	3H-5HT	-2	24	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3817	116	3H-5HT	-2	24	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3817	116	3H-5HT	-2	24	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3817	116	3H-5HT	-2	24	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	213	3792	50	3H-5HT	-3	43	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	2717	3792	50	3H-5HT	-3	43	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	5533	3792	50	3H-5HT	-3	43	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	CHEMBL621	3792	50	3H-5HT	-3	43	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	DB00656	3792	50	3H-5HT	-3	43	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	21830793	91403	5	3H-8-OH-DPAT	-489	46	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
	CHEMBL2413154	91403	5	3H-8-OH-DPAT	-489	46	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
	45266826	215954	0	[3H] LSD	2	8	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	177	3	1	2	1.8	CC1=CC=C(C=C1)C(=O)C(C)NC	None
	179	396	107	3H-LSD	-17	50	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	2159	396	107	3H-LSD	-17	50	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	963	396	107	3H-LSD	-17	50	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	CHEMBL243712	396	107	3H-LSD	-17	50	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	DB06288	396	107	3H-LSD	-17	50	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	24740863	88728	0	UNDEFINED	1	6	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	385	6	1	5	5.0	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1Cl	None
	CHEMBL236610	88728	0	UNDEFINED	1	6	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	385	6	1	5	5.0	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1Cl	None
	1524	2150	89	3H-5HT	-218	51	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2150	89	3H-5HT	-218	51	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2150	89	3H-5HT	-218	51	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2150	89	3H-5HT	-218	51	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2150	89	3H-5HT	-218	51	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2150	89	3H-5HT	-218	51	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	5	139	66	3H-KETANSERIN	-1778	54	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-KETANSERIN	-1778	54	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-KETANSERIN	-1778	54	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-KETANSERIN	-1778	54	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	77590	214176	0	3H-5HT	-10	6	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	124	4	0	2	0.8	COCCOCCl	None
	221	3435	63	3H-5HT	-4	13	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	3277600	3435	63	3H-5HT	-4	13	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	CHEMBL323356	3435	63	3H-5HT	-4	13	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	None	214703	0	UNDEFINED	1	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
	206	2457	10	3H-KETANSERIN	-5	24	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2457	10	3H-KETANSERIN	-5	24	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2457	10	3H-KETANSERIN	-5	24	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	134551	355	25	None	-6	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
	271	355	25	None	-6	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
	885	355	25	None	-6	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
	CHEMBL1403281	355	25	None	-6	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
	135	2496	38	None	-3	57	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2496	38	None	-3	57	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2496	38	None	-3	57	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2496	38	None	-3	57	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2496	38	None	-3	57	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	2247	502	77	None	-4	41	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	249	502	77	None	-4	41	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	2603	502	77	None	-4	41	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	CHEMBL296419	502	77	None	-4	41	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	DB00637	502	77	None	-4	41	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	1385580	29063	73	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	None
	4615	29063	73	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	None
	CHEMBL13828	29063	73	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	None
	191	399	92	None	-5	28	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	201	399	92	None	-5	28	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	2170	399	92	None	-5	28	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	CHEMBL1113	399	92	None	-5	28	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	DB00543	399	92	None	-5	28	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	2601	3721	30	None	-8	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	443951	3721	30	None	-8	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	56	3721	30	None	-8	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL73151	3721	30	None	-8	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB13399	3721	30	None	-8	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	135398737	944	89	None	-2	91	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	944	89	None	-2	91	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	944	89	None	-2	91	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	944	89	None	-2	91	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	944	89	None	-2	91	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	10531	1392	18	None	-15	24	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	121	1392	18	None	-15	24	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	888	1392	18	None	-15	24	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	CHEMBL1732	1392	18	None	-15	24	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	DB00320	1392	18	None	-15	24	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	107715	199260	18	None	-14	20	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	None
	CHEMBL1255837	199260	18	None	-14	20	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	None
	CHEMBL601773	199260	18	None	-14	20	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	None
	135526515	216000	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	301	7	4	3	2.8	CCCCCNC(=N)NN=CC1=CNC2=C1C=C(OC)C=C2	None
	1588	2294	24	None	-8	43	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2294	24	None	-8	43	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2294	24	None	-8	43	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2294	24	None	-8	43	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2294	24	None	-8	43	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	135398737	944	89	3H-5HT	-2	91	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	944	89	3H-5HT	-2	91	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	944	89	3H-5HT	-2	91	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	944	89	3H-5HT	-2	91	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	944	89	3H-5HT	-2	91	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	1042	1551	20	None	-7	16	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
	148	1551	20	None	-7	16	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
	443884	1551	20	None	-7	16	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
	CHEMBL119443	1551	20	None	-7	16	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
	DB01253	1551	20	None	-7	16	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
	2220	3085	78	None	-1	13	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	27400	3085	78	None	-1	13	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	93	3085	78	None	-1	13	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	CHEMBL294951	3085	78	None	-1	13	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	DB06153	3085	78	None	-1	13	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	3337	214441	0	Functional	-75	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	65801	214441	0	Functional	-75	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	66264	214441	0	Functional	-75	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	91452	214441	0	Functional	-75	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	11978813	713	72	None	-2	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
	5014	713	72	None	-2	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
	7672	713	72	None	-2	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
	CHEMBL2105760	713	72	None	-2	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
	DB09128	713	72	None	-2	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
	133	2460	48	None	-2	42	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2460	48	None	-2	42	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2460	48	None	-2	42	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2460	48	None	-2	42	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2460	48	None	-2	42	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	277	1274	55	None	-5	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1274	55	None	-5	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1274	55	None	-5	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1274	55	None	-5	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1274	55	None	-5	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	37	766	56	None	1	17	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
	460	766	56	None	1	17	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
	54746	766	56	None	1	17	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
	CHEMBL1201087	766	56	None	1	17	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
	DB00248	766	56	None	1	17	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
	11954224	214174	0	None	-66	59	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	1621	2396	16	Functional	-19	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2396	16	Functional	-19	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2396	16	Functional	-19	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2396	16	Functional	-19	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2396	16	Functional	-19	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	135	2496	38	3H-5HT	-3	57	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2496	38	3H-5HT	-3	57	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2496	38	3H-5HT	-3	57	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2496	38	3H-5HT	-3	57	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2496	38	3H-5HT	-3	57	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	None	214191	0	3H-KETANSERIN	-	1	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	259	5	1	3	2.6	CCC1=CC(=C(C=C1OC)CC(C)N)OC.Cl	None
	3036864	201066	16	3H-5HT	-346	27	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1256645	201066	16	3H-5HT	-346	27	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1814790	201066	16	3H-5HT	-346	27	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL62	201066	16	3H-5HT	-346	27	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	213	3792	50	3H-5HT	-3	43	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	2717	3792	50	3H-5HT	-3	43	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	5533	3792	50	3H-5HT	-3	43	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	CHEMBL621	3792	50	3H-5HT	-3	43	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	DB00656	3792	50	3H-5HT	-3	43	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	115	3732	78	3H-5HT	-2	26	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	4296	3732	78	3H-5HT	-2	26	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	CHEMBL274866	3732	78	3H-5HT	-2	26	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	173	3211	88	3H-5HT	1	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	5011	3211	88	3H-5HT	1	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	CHEMBL18772	3211	88	3H-5HT	1	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	115	3732	78	3H-5HT	-2	26	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	4296	3732	78	3H-5HT	-2	26	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	CHEMBL274866	3732	78	3H-5HT	-2	26	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	2337	3205	72	3H-LSD	-15	62	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3205	72	3H-LSD	-15	62	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3205	72	3H-LSD	-15	62	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3205	72	3H-LSD	-15	62	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3205	72	3H-LSD	-15	62	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	134	2478	19	3H-5HT	-12	67	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2478	19	3H-5HT	-12	67	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2478	19	3H-5HT	-12	67	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2478	19	3H-5HT	-12	67	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2478	19	3H-5HT	-12	67	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	119376	1811	41	3H-5HT	-4786	26	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
	247	1811	41	3H-5HT	-4786	26	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
	CHEMBL33884	1811	41	3H-5HT	-4786	26	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
	71299720	214172	0	3H-5HT	-691	16	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	450	3	2	6	3.0	CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4.C(=CC(=O)O)C(=O)O	None
	1220	186	46	Functional	-1905	44	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	186	46	Functional	-1905	44	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	186	46	Functional	-1905	44	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	186	46	Functional	-1905	44	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	150	2473	18	None	1	15	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
	1764	2473	18	None	1	15	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
	8226	2473	18	None	1	15	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
	CHEMBL1201356	2473	18	None	1	15	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
	DB00353	2473	18	None	1	15	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
	134	2478	19	3H-5HT	-2	67	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2478	19	3H-5HT	-2	67	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2478	19	3H-5HT	-2	67	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2478	19	3H-5HT	-2	67	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2478	19	3H-5HT	-2	67	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	107	141	116	3H-5HT	-12	30	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	116	3H-5HT	-12	30	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	116	3H-5HT	-12	30	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	107	141	116	3H-5HT	-12	30	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	116	3H-5HT	-12	30	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	116	3H-5HT	-12	30	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	11154555	788	57	None	-39	12	Human	8.0	pKi	=	8.0	Binding	CHO-K1 cells, [3H]LSD (1.2nM)CHO-K1 cells, [3H]LSD (1.2nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	5037	788	57	None	-39	12	Human	8.0	pKi	=	8.0	Binding	CHO-K1 cells, [3H]LSD (1.2nM)CHO-K1 cells, [3H]LSD (1.2nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	7671	788	57	None	-39	12	Human	8.0	pKi	=	8.0	Binding	CHO-K1 cells, [3H]LSD (1.2nM)CHO-K1 cells, [3H]LSD (1.2nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL2028019	788	57	None	-39	12	Human	8.0	pKi	=	8.0	Binding	CHO-K1 cells, [3H]LSD (1.2nM)CHO-K1 cells, [3H]LSD (1.2nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL3085826	788	57	None	-39	12	Human	8.0	pKi	=	8.0	Binding	CHO-K1 cells, [3H]LSD (1.2nM)CHO-K1 cells, [3H]LSD (1.2nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB06016	788	57	None	-39	12	Human	8.0	pKi	=	8.0	Binding	CHO-K1 cells, [3H]LSD (1.2nM)CHO-K1 cells, [3H]LSD (1.2nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	134	2478	19	None	-2	67	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cellsDisplacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cells	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2478	19	None	-2	67	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cellsDisplacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cells	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2478	19	None	-2	67	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cellsDisplacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cells	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2478	19	None	-2	67	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cellsDisplacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cells	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2478	19	None	-2	67	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cellsDisplacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cells	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	242	467	117	None	-1	51	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	467	117	None	-1	51	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	467	117	None	-1	51	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	467	117	None	-1	51	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	467	117	None	-1	51	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	5	139	66	3H-5HT	-13	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-5HT	-13	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-5HT	-13	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-5HT	-13	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	135	2496	38	3H-5HT	-3	57	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2496	38	3H-5HT	-3	57	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2496	38	3H-5HT	-3	57	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2496	38	3H-5HT	-3	57	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2496	38	3H-5HT	-3	57	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	46780481	107045	18	None	-57	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	9903970	107045	18	None	-57	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3187365	107045	18	None	-57	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3544974	107045	18	None	-57	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	5	139	66	3H-5HT	-13	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-5HT	-13	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-5HT	-13	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-5HT	-13	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	11848625	5715	0	UNDEFINED	2	6	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	451	8	1	7	4.9	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)cc(OC2CCOCC2)c1	None
	CHEMBL1078745	5715	0	UNDEFINED	2	6	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	451	8	1	7	4.9	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)cc(OC2CCOCC2)c1	None
	62787	204467	17	3H-5HT	-3	9	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	195	4	1	3	1.6	COc1ccc(OC)c(CC(C)N)c1	None
	CHEMBL8642	204467	17	3H-5HT	-3	9	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	195	4	1	3	1.6	COc1ccc(OC)c(CC(C)N)c1	None
	7153	97570	74	3H-KETANSERIN	-50	33	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97570	74	3H-KETANSERIN	-50	33	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	None	214255	0	3H-5HT	-10	4	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase		None	None	None		None	None
	None	214705	0	3H-5HT	-43	3	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	419	6	1	4	3.4	C1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CCCOC4=CC=C(C=C4)F.Cl	None
	10624	69957	17	3H-LSD	1	32	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
	138543650	69957	17	3H-LSD	1	32	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
	CHEMBL194378	69957	17	3H-LSD	1	32	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
	282	1391	0	None	-371	7	Human	7.5	pKi	=	7.5	Binding	Biased for β-arrestin signalling.Biased for β-arrestin signalling.	Guide to Pharmacology	577	5	3	6	2.5	CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	23519215
	522609	1391	0	None	-371	7	Human	7.5	pKi	=	7.5	Binding	Biased for β-arrestin signalling.Biased for β-arrestin signalling.	Guide to Pharmacology	577	5	3	6	2.5	CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	23519215
	1621	2396	16	None	-19	44	Human	8.4	pKi	=	8.4	Binding	Biased for β-arrestin sihnalling.Biased for β-arrestin sihnalling.	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	23519215
	17	2396	16	None	-19	44	Human	8.4	pKi	=	8.4	Binding	Biased for β-arrestin sihnalling.Biased for β-arrestin sihnalling.	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	23519215
	5761	2396	16	None	-19	44	Human	8.4	pKi	=	8.4	Binding	Biased for β-arrestin sihnalling.Biased for β-arrestin sihnalling.	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	23519215
	CHEMBL263881	2396	16	None	-19	44	Human	8.4	pKi	=	8.4	Binding	Biased for β-arrestin sihnalling.Biased for β-arrestin sihnalling.	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	23519215
	DB04829	2396	16	None	-19	44	Human	8.4	pKi	=	8.4	Binding	Biased for β-arrestin sihnalling.Biased for β-arrestin sihnalling.	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	23519215
	10287037	619	0	None	31	2	Human	10.1	pKi	=	10.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	367	3	0	4	5.1	CCOc1ccc2c(c1)Sc1c(C2=C2CCN(CC2)C)c(OC)ccc1	25666387
	8424	619	0	None	31	2	Human	10.1	pKi	=	10.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	367	3	0	4	5.1	CCOc1ccc2c(c1)Sc1c(C2=C2CCN(CC2)C)c(OC)ccc1	25666387
	2	3210	19	None	-363	28	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	12388666
	2	3210	19	None	-363	28	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	15322733
	54562	3210	19	None	-363	28	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	12388666
	54562	3210	19	None	-363	28	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	15322733
	CHEMBL240773	3210	19	None	-363	28	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	12388666
	CHEMBL240773	3210	19	None	-363	28	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	15322733
	11658860	2312	47	None	-1	3	Human	6.8	pKi	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
	2941	2312	47	None	-1	3	Human	6.8	pKi	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
	4374	2312	47	None	-1	3	Human	6.8	pKi	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
	CHEMBL360328	2312	47	None	-1	3	Human	6.8	pKi	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
	DB04871	2312	47	None	-1	3	Human	6.8	pKi	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
	45275554	3260	0	None	-6	3	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	9	3	6	3.7	COc1cc(N)c(cc1C(=O)NCC1CCN(CC1)CC[C@@H](c1ccc(cc1)F)OC(=O)N)Cl	25316608
	8427	3260	0	None	-6	3	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	9	3	6	3.7	COc1cc(N)c(cc1C(=O)NCC1CCN(CC1)CC[C@@H](c1ccc(cc1)F)OC(=O)N)Cl	25316608
	CHEMBL3544975	3260	0	None	-6	3	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	9	3	6	3.7	COc1cc(N)c(cc1C(=O)NCC1CCN(CC1)CC[C@@H](c1ccc(cc1)F)OC(=O)N)Cl	25316608
	DB12798	3260	0	None	-6	3	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	9	3	6	3.7	COc1cc(N)c(cc1C(=O)NCC1CCN(CC1)CC[C@@H](c1ccc(cc1)F)OC(=O)N)Cl	25316608
	11957541	1430	38	None	-4	15	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
	11957541	1430	38	None	-4	15	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8450835
	1229	1430	38	None	-4	15	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
	1229	1430	38	None	-4	15	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8450835
	147	1430	38	None	-4	15	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
	147	1430	38	None	-4	15	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8450835
	170617	1430	38	None	-4	15	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
	170617	1430	38	None	-4	15	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8450835
	CHEMBL6616	1430	38	None	-4	15	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
	CHEMBL6616	1430	38	None	-4	15	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8450835
	11957541	1430	38	None	-1	15	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	12970106
	11957541	1430	38	None	-1	15	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
	11957541	1430	38	None	-1	15	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	9933142
	1229	1430	38	None	-1	15	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	12970106
	1229	1430	38	None	-1	15	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
	1229	1430	38	None	-1	15	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	9933142
	147	1430	38	None	-1	15	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	12970106
	147	1430	38	None	-1	15	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
	147	1430	38	None	-1	15	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	9933142
	170617	1430	38	None	-1	15	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	12970106
	170617	1430	38	None	-1	15	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
	170617	1430	38	None	-1	15	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	9933142
	CHEMBL6616	1430	38	None	-1	15	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	12970106
	CHEMBL6616	1430	38	None	-1	15	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
	CHEMBL6616	1430	38	None	-1	15	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	9933142
	161	743	3	None	2	6	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	12970106
	161	743	3	None	2	6	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	15322733
	161	743	3	None	2	6	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	15466450
	4284720	743	3	None	2	6	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	12970106
	4284720	743	3	None	2	6	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	15322733
	4284720	743	3	None	2	6	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	15466450
	CHEMBL1255834	743	3	None	2	6	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	12970106
	CHEMBL1255834	743	3	None	2	6	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	15322733
	CHEMBL1255834	743	3	None	2	6	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	15466450
	166	3307	12	None	1	3	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	15322733
	3045227	3307	12	None	1	3	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	15322733
	CHEMBL76781	3307	12	None	1	3	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	15322733
	135	2496	38	None	-3	57	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10455251
	135	2496	38	None	-3	57	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	15322733
	135	2496	38	None	-3	57	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9459568
	1796	2496	38	None	-3	57	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10455251
	1796	2496	38	None	-3	57	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	15322733
	1796	2496	38	None	-3	57	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9459568
	4184	2496	38	None	-3	57	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10455251
	4184	2496	38	None	-3	57	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	15322733
	4184	2496	38	None	-3	57	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9459568
	CHEMBL6437	2496	38	None	-3	57	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10455251
	CHEMBL6437	2496	38	None	-3	57	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	15322733
	CHEMBL6437	2496	38	None	-3	57	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9459568
	DB06148	2496	38	None	-3	57	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10455251
	DB06148	2496	38	None	-3	57	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	15322733
	DB06148	2496	38	None	-3	57	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9459568
	134	2478	19	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11104741
	134	2478	19	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	15322733
	134	2478	19	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9459568
	1775	2478	19	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11104741
	1775	2478	19	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	15322733
	1775	2478	19	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9459568
	9681	2478	19	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11104741
	9681	2478	19	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	15322733
	9681	2478	19	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9459568
	CHEMBL1065	2478	19	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11104741
	CHEMBL1065	2478	19	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	15322733
	CHEMBL1065	2478	19	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9459568
	DB00247	2478	19	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11104741
	DB00247	2478	19	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	15322733
	DB00247	2478	19	None	-2	67	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9459568
	176	1508	0	None	19	3	Human	9.0	pKi	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	4	1	5	2.8	Nc1cc(N2CCN(CC2)Cc2ccccc2)c(cc1C)[N+](=O)[O-]	15107597
	9930789	1508	0	None	19	3	Human	9.0	pKi	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	4	1	5	2.8	Nc1cc(N2CCN(CC2)Cc2ccccc2)c(cc1C)[N+](=O)[O-]	15107597
	CHEMBL1628720	1508	0	None	19	3	Human	9.0	pKi	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	4	1	5	2.8	Nc1cc(N2CCN(CC2)Cc2ccccc2)c(cc1C)[N+](=O)[O-]	15107597
	188	3339	73	None	-1	6	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10455251
	188	3339	73	None	-1	6	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	15322733
	196968	3339	73	None	-1	6	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10455251
	196968	3339	73	None	-1	6	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	15322733
	CHEMBL473186	3339	73	None	-1	6	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10455251
	CHEMBL473186	3339	73	None	-1	6	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	15322733
	3763	215984	0	None	-	1	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	184	2	0	1	2.4	FC(F)OC(Cl)C(F)(F)F	None
	202	1480	0	None	-1	31	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	60835	1480	0	None	-1	31	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	972	1480	0	None	-1	31	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	CHEMBL1175	1480	0	None	-1	31	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	DB00476	1480	0	None	-1	31	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	3337	214441	0	None	-75	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	65801	214441	0	None	-75	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	66264	214441	0	None	-75	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	91452	214441	0	None	-75	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	4450	215991	0	None	-1	3	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	253	1	0	2	3.2	CN1CCOC(C2=CC=CC=C2)C2=CC=CC=C2C1	None
	6166	214253	0	None	-4	4	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	330	2	1	3	3.7	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)CO)CCC4=CC(=O)CC[C@]34C	None
	179	396	107	None	-17	50	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	2159	396	107	None	-17	50	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	963	396	107	None	-17	50	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	CHEMBL243712	396	107	None	-17	50	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	DB06288	396	107	None	-17	50	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	1357	2450	133	None	-3890	8	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12750432
	1672	2450	133	None	-3890	8	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12750432
	224	2450	133	None	-3890	8	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12750432
	896	2450	133	None	-3890	8	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12750432
	CHEMBL45	2450	133	None	-3890	8	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12750432
	DB01065	2450	133	None	-3890	8	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12750432
	1209	1628	69	None	-199	31	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	11104741
	203	1628	69	None	-199	31	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	11104741
	3386	1628	69	None	-199	31	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	11104741
	CHEMBL41	1628	69	None	-199	31	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	11104741
	DB00472	1628	69	None	-199	31	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	11104741
	208	2820	0	None	-69	12	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	11104741
	4541	2820	0	None	-69	12	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	11104741
	CHEMBL1494	2820	0	None	-69	12	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	11104741
	1220	186	46	None	-1905	44	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	15322733
	1220	186	46	None	-3235	44	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8450835
	31	186	46	None	-1905	44	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	15322733
	31	186	46	None	-3235	44	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8450835
	7	186	46	None	-1905	44	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	15322733
	7	186	46	None	-3235	44	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8450835
	CHEMBL56	186	46	None	-1905	44	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	15322733
	CHEMBL56	186	46	None	-3235	44	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8450835
	1524	2150	89	None	-2570	51	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8450835
	197	2150	89	None	-2570	51	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8450835
	3822	2150	89	None	-2570	51	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8450835
	88	2150	89	None	-2570	51	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8450835
	CHEMBL51	2150	89	None	-2570	51	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8450835
	DB12465	2150	89	None	-2570	51	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8450835
	186	1777	47	None	-338	16	Human	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	15322733
	71781	1777	47	None	-338	16	Human	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	15322733
	CHEMBL18972	1777	47	None	-338	16	Human	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	15322733
	2470	3596	46	None	-120226	59	Rat	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8450835
	3300	3596	46	None	-120226	59	Rat	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8450835
	5265	3596	46	None	-120226	59	Rat	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8450835
	99	3596	46	None	-120226	59	Rat	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8450835
	CHEMBL267930	3596	46	None	-120226	59	Rat	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8450835
	2176	3077	66	None	-933	26	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	15322733
	4828	3077	66	None	-933	26	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	15322733
	91	3077	66	None	-933	26	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	15322733
	CHEMBL500	3077	66	None	-933	26	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	15322733
	DB00960	3077	66	None	-933	26	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	15322733
	29	780	0	None	-2511	9	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	456	5	1	8	3.4	Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1	12130738
	9805719	780	0	None	-2511	9	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	456	5	1	8	3.4	Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1	12130738
	CHEMBL2027925	780	0	None	-2511	9	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	456	5	1	8	3.4	Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1	12130738
	18971832	2385	0	None	-263	13	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	9395253
	21	2385	0	None	-263	13	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	9395253
	CHEMBL3186179	2385	0	None	-263	13	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	9395253
	28	3440	37	None	-954	10	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9303567
	3292447	3440	37	None	-954	10	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9303567
	CHEMBL20963	3440	37	None	-954	10	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9303567
	2202	3083	91	None	-6	21	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	12388666
	4850	3083	91	None	-6	21	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	12388666
	49	3083	91	None	-6	21	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	12388666
	CHEMBL1371770	3083	91	None	-6	21	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	12388666
	DB12478	3083	91	None	-6	21	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	12388666
	130	3444	43	None	-478	13	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	15322733
	3378093	3444	43	None	-478	13	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	15322733
	CHEMBL281350	3444	43	None	-478	13	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	15322733
	143	3459	45	None	-158	7	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10945872
	5311096	3459	45	None	-158	7	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10945872
	CHEMBL85606	3459	45	None	-158	7	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10945872
	175	3598	38	None	-331	7	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	6	1	4	3.0	Fc1ccc(cc1)OCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	15322733
	68186	3598	38	None	-331	7	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	6	1	4	3.0	Fc1ccc(cc1)OCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	15322733
	CHEMBL79834	3598	38	None	-331	7	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	6	1	4	3.0	Fc1ccc(cc1)OCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	15322733
	185	3943	54	None	-2344	37	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	10188965
	185	3943	54	None	-2344	37	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	15322733
	5311271	3943	54	None	-2344	37	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	10188965
	5311271	3943	54	None	-2344	37	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	15322733
	CHEMBL74355	3943	54	None	-2344	37	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	10188965
	CHEMBL74355	3943	54	None	-2344	37	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	15322733
	DB16351	3943	54	None	-2344	37	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	10188965
	DB16351	3943	54	None	-2344	37	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	15322733
	187	3336	15	None	-288	4	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	612	11	3	8	3.6	COc1cc(OC)c(cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O)NS(=O)(=O)c1ccc(cc1)C(F)(F)F	15322733
	187	3336	15	None	-288	4	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	612	11	3	8	3.6	COc1cc(OC)c(cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O)NS(=O)(=O)c1ccc(cc1)C(F)(F)F	9225287
	3693566	3336	15	None	-288	4	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	612	11	3	8	3.6	COc1cc(OC)c(cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O)NS(=O)(=O)c1ccc(cc1)C(F)(F)F	15322733
	3693566	3336	15	None	-288	4	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	612	11	3	8	3.6	COc1cc(OC)c(cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O)NS(=O)(=O)c1ccc(cc1)C(F)(F)F	9225287
	CHEMBL88402	3336	15	None	-288	4	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	612	11	3	8	3.6	COc1cc(OC)c(cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O)NS(=O)(=O)c1ccc(cc1)C(F)(F)F	15322733
	CHEMBL88402	3336	15	None	-288	4	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	612	11	3	8	3.6	COc1cc(OC)c(cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O)NS(=O)(=O)c1ccc(cc1)C(F)(F)F	9225287
	1353	1880	85	None	-295	85	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9459568
	3559	1880	85	None	-295	85	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9459568
	86	1880	85	None	-295	85	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9459568
	CHEMBL54	1880	85	None	-295	85	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9459568
	DB00502	1880	85	None	-295	85	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9459568
	109	889	23	None	-281	7	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	1	0	4	3.3	CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F	15322733
	2689	889	23	None	-281	7	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	1	0	4	3.3	CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F	15322733
	CHEMBL27403	889	23	None	-281	7	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	1	0	4	3.3	CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F	15322733
	2470	3596	46	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	15322733
	2470	3596	46	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8078486
	2470	3596	46	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9459568
	3300	3596	46	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	15322733
	3300	3596	46	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8078486
	3300	3596	46	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9459568
	5265	3596	46	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	15322733
	5265	3596	46	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8078486
	5265	3596	46	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9459568
	99	3596	46	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	15322733
	99	3596	46	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8078486
	99	3596	46	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9459568
	CHEMBL267930	3596	46	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	15322733
	CHEMBL267930	3596	46	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8078486
	CHEMBL267930	3596	46	None	-14125	59	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9459568
	107780	1814	50	None	-676	17	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9303567
	14	1814	50	None	-676	17	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9303567
	CHEMBL15928	1814	50	None	-676	17	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9303567
	133633	2210	46	None	-87	8	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	4.3	Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2	10869410
	177	2210	46	None	-87	8	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	4.3	Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2	10869410
	CHEMBL445102	2210	46	None	-87	8	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	4.3	Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2	10869410
	177336	3071	45	None	-1412	3	Human	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	6	1	4	3.7	CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2	11504648
	225	3071	45	None	-1412	3	Human	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	6	1	4	3.7	CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2	11504648
	CHEMBL356359	3071	45	None	-1412	3	Human	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	6	1	4	3.7	CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2	11504648
	DB04873	3071	45	None	-1412	3	Human	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	6	1	4	3.7	CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2	11504648
	1524	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	12738034
	1524	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	15322733
	1524	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8078486
	1524	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8845011
	1524	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9459568
	197	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	12738034
	197	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	15322733
	197	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8078486
	197	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8845011
	197	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9459568
	3822	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	12738034
	3822	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	15322733
	3822	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8078486
	3822	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8845011
	3822	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9459568
	88	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	12738034
	88	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	15322733
	88	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8078486
	88	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8845011
	88	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9459568
	CHEMBL51	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	12738034
	CHEMBL51	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	15322733
	CHEMBL51	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8078486
	CHEMBL51	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8845011
	CHEMBL51	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9459568
	DB12465	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	12738034
	DB12465	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	15322733
	DB12465	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8078486
	DB12465	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8845011
	DB12465	2150	89	None	-218	51	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9459568
	107992	2516	47	None	-5	9	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	8450835
	165	2516	47	None	-5	9	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	8450835
	CHEMBL269521	2516	47	None	-5	9	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	8450835
	DB12111	2516	47	None	-5	9	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	8450835
	107992	2516	47	None	-1	9	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	12970106
	107992	2516	47	None	-1	9	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	15322733
	165	2516	47	None	-1	9	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	12970106
	165	2516	47	None	-1	9	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	15322733
	CHEMBL269521	2516	47	None	-1	9	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	12970106
	CHEMBL269521	2516	47	None	-1	9	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	15322733
	DB12111	2516	47	None	-1	9	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	12970106
	DB12111	2516	47	None	-1	9	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	15322733
	5268	3599	34	None	-1047	17	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	9459568
	53	3599	34	None	-1047	17	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	9459568
	CHEMBL300555	3599	34	None	-1047	17	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	9459568
	1574	81	52	None	-3	20	Rat	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	8450835
	218	81	52	None	-3	20	Rat	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	8450835
	CHEMBL266591	81	52	None	-3	20	Rat	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	8450835
	198	310	120	None	-346	5	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12750432
	82148	310	120	None	-346	5	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12750432
	99	310	120	None	-346	5	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12750432
	CHEMBL10878	310	120	None	-346	5	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12750432
	DB06594	310	120	None	-346	5	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12750432
	177336	3071	45	None	-1412	3	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	6	1	4	3.7	CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2	15466450
	225	3071	45	None	-1412	3	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	6	1	4	3.7	CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2	15466450
	CHEMBL356359	3071	45	None	-1412	3	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	6	1	4	3.7	CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2	15466450
	DB04873	3071	45	None	-1412	3	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	6	1	4	3.7	CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2	15466450
	210	3421	0	None	-7	3	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	12738034
	2423	3421	0	None	-7	3	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	12738034
	5160	3421	0	None	-7	3	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	12738034
	CHEMBL52939	3421	0	None	-7	3	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	12738034
	DB12163	3421	0	None	-7	3	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	12738034
	195	3514	5	None	-25	4	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	0	0	2	2.1	CN1CC[C@H]2[C@@H](C1)c1cccc3c1N(C2)CC3	15322733
	9859407	3514	5	None	-25	4	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	0	0	2	2.1	CN1CC[C@H]2[C@@H](C1)c1cccc3c1N(C2)CC3	15322733
	CHEMBL316069	3514	5	None	-25	4	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	0	0	2	2.1	CN1CC[C@H]2[C@@H](C1)c1cccc3c1N(C2)CC3	15322733
	1809	134	28	None	-999	36	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	15322733
	1809	134	28	None	-999	36	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8078486
	4	134	28	None	-999	36	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	15322733
	4	134	28	None	-999	36	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8078486
	CHEMBL18840	134	28	None	-999	36	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	15322733
	CHEMBL18840	134	28	None	-999	36	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8078486
	1809	134	28	None	-1659	36	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8078486
	1809	134	28	None	-1659	36	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8450835
	4	134	28	None	-1659	36	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8078486
	4	134	28	None	-1659	36	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8450835
	CHEMBL18840	134	28	None	-1659	36	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8078486
	CHEMBL18840	134	28	None	-1659	36	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8450835
	129	3385	7	None	-562	9	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	7	1	4	4.8	N#Cc1ccc2c(c1)[C@H]1CN(C[C@@H]1CO2)CCCCNC(=O)c1ccc(cc1)c1ccccc1	10869410
	9868452	3385	7	None	-562	9	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	7	1	4	4.8	N#Cc1ccc2c(c1)[C@H]1CN(C[C@@H]1CO2)CCCCNC(=O)c1ccc(cc1)c1ccccc1	10869410
	CHEMBL65280	3385	7	None	-562	9	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	7	1	4	4.8	N#Cc1ccc2c(c1)[C@H]1CN(C[C@@H]1CO2)CCCCNC(=O)c1ccc(cc1)c1ccccc1	10869410
	193	3450	38	None	-707	4	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	15322733
	193	3450	38	None	-707	4	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	9225286
	3644637	3450	38	None	-707	4	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	15322733
	3644637	3450	38	None	-707	4	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	9225286
	CHEMBL14563	3450	38	None	-707	4	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	15322733
	CHEMBL14563	3450	38	None	-707	4	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	9225286
	228	441	26	None	-5	24	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	12388666
	33	441	26	None	-5	24	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	12388666
	6005	441	26	None	-5	24	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	12388666
	CHEMBL53	441	26	None	-5	24	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	12388666
	DB00714	441	26	None	-5	24	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	12388666
	173	3211	88	None	-3	22	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	8450835
	5011	3211	88	None	-3	22	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	8450835
	CHEMBL18772	3211	88	None	-3	22	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	8450835
	108029	3361	50	None	-125	13	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	15322733
	23	3361	50	None	-125	13	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	15322733
	CHEMBL18785	3361	50	None	-125	13	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	15322733
	221	3435	63	None	-4	13	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	15322733
	3277600	3435	63	None	-4	13	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	15322733
	CHEMBL323356	3435	63	None	-4	13	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	15322733
	170	2917	0	None	-6	3	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	265	1	1	3	2.2	FC(c1ccc(nc1Cl)N1CCNCC1)(F)F	15322733
	9796408	2917	0	None	-6	3	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	265	1	1	3	2.2	FC(c1ccc(nc1Cl)N1CCNCC1)(F)F	15322733
	CHEMBL506999	2917	0	None	-6	3	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	265	1	1	3	2.2	FC(c1ccc(nc1Cl)N1CCNCC1)(F)F	15322733
	194	3451	25	None	-100	3	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10737744
	443391	3451	25	None	-100	3	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10737744
	CHEMBL14460	3451	25	None	-100	3	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10737744
	1150	3817	116	None	-2	24	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	15322733
	1150	3817	116	None	-8	24	Rat	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8450835
	125	3817	116	None	-2	24	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	15322733
	125	3817	116	None	-8	24	Rat	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8450835
	CHEMBL6640	3817	116	None	-2	24	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	15322733
	CHEMBL6640	3817	116	None	-8	24	Rat	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8450835
	DB08653	3817	116	None	-2	24	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	15322733
	DB08653	3817	116	None	-8	24	Rat	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8450835
	173	3211	88	None	1	22	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	15322733
	5011	3211	88	None	1	22	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	15322733
	CHEMBL18772	3211	88	None	1	22	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	15322733
	115	3732	78	None	-2	26	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	8450835
	4296	3732	78	None	-2	26	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	8450835
	CHEMBL274866	3732	78	None	-2	26	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	8450835
	213	3792	50	None	-3	43	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	11104741
	213	3792	50	None	-3	43	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	15322733
	2717	3792	50	None	-3	43	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	11104741
	2717	3792	50	None	-3	43	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	15322733
	5533	3792	50	None	-3	43	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	11104741
	5533	3792	50	None	-3	43	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	15322733
	CHEMBL621	3792	50	None	-3	43	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	11104741
	CHEMBL621	3792	50	None	-3	43	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	15322733
	DB00656	3792	50	None	-3	43	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	11104741
	DB00656	3792	50	None	-3	43	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	15322733
	115	3732	78	None	-1	26	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	15322733
	4296	3732	78	None	-1	26	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	15322733
	CHEMBL274866	3732	78	None	-1	26	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	15322733
	31101	720	39	None	-26	35	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
	35	720	39	None	-26	35	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
	403	720	39	None	-26	35	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
	CHEMBL493	720	39	None	-26	35	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
	DB01200	720	39	None	-26	35	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
	135	2496	38	None	-37	57	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8450835
	1796	2496	38	None	-37	57	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8450835
	4184	2496	38	None	-37	57	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8450835
	CHEMBL6437	2496	38	None	-37	57	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8450835
	DB06148	2496	38	None	-37	57	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8450835
	15897	2817	0	None	12	36	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	11104741
	215	2817	0	None	12	36	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	11104741
	CHEMBL1979333	2817	0	None	12	36	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	11104741
	12895728	2818	0	None	-	1	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	2	1	1	2.6	C[C@H](Cc1cccc(c1)C(F)(F)F)N	11104741
	217	2818	0	None	-	1	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	2	1	1	2.6	C[C@H](Cc1cccc(c1)C(F)(F)F)N	11104741
	CHEMBL250881	2818	0	None	-	1	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	2	1	1	2.6	C[C@H](Cc1cccc(c1)C(F)(F)F)N	11104741
	102	4064	44	None	-100	49	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8450835
	3659	4064	44	None	-100	49	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8450835
	8969	4064	44	None	-100	49	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8450835
	CHEMBL15245	4064	44	None	-100	49	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8450835
	DB01392	4064	44	None	-100	49	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8450835
	157	2038	5	None	-20	4	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	15322733
	157	2038	5	None	-20	4	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	9857084
	9840090	2038	5	None	-20	4	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	15322733
	9840090	2038	5	None	-20	4	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	9857084
	CHEMBL134519	2038	5	None	-20	4	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	15322733
	CHEMBL134519	2038	5	None	-20	4	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	9857084
	10	715	23	None	-3	9	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	406	6	1	3	4.7	Clc1cccc(c1)N1CCN(CC1)CC(C(c1ccccc1)c1ccccc1)O	9303567
	3654103	715	23	None	-3	9	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	406	6	1	3	4.7	Clc1cccc(c1)N1CCN(CC1)CC(C(c1ccccc1)c1ccccc1)O	9303567
	CHEMBL534232	715	23	None	-3	9	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	406	6	1	3	4.7	Clc1cccc(c1)N1CCN(CC1)CC(C(c1ccccc1)c1ccccc1)O	9303567
	206	2457	10	None	-26	24	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8450835
	68848	2457	10	None	-26	24	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8450835
	CHEMBL12314	2457	10	None	-26	24	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8450835
	171	2919	0	None	-5	3	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	233	3	1	3	1.9	COc1ccc2c(c1O[C@@H]1CNCC1)CCC2	15322733
	9794656	2919	0	None	-5	3	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	233	3	1	3	1.9	COc1ccc2c(c1O[C@@H]1CNCC1)CCC2	15322733
	136	3240	28	None	-85	16	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8450835
	223	3240	28	None	-85	16	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8450835
	643606	3240	28	None	-85	16	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8450835
	CHEMBL10347	3240	28	None	-85	16	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8450835
	155	719	20	None	-5	12	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	15322733
	155	719	20	None	-5	12	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	9933142
	163	719	20	None	-5	12	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	15322733
	163	719	20	None	-5	12	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	9933142
	62065	719	20	None	-5	12	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	15322733
	62065	719	20	None	-5	12	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	9933142
	CHEMBL6607	719	20	None	-5	12	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	15322733
	CHEMBL6607	719	20	None	-5	12	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	9933142
	DB01484	719	20	None	-5	12	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	15322733
	DB01484	719	20	None	-5	12	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	9933142
	219050	3321	21	None	-194	21	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	12388666
	52	3321	21	None	-194	21	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	12388666
	CHEMBL431367	3321	21	None	-194	21	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	12388666
	168	3919	11	None	-3	3	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	15322733
	6604042	3919	11	None	-3	3	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	15322733
	CHEMBL309760	3919	11	None	-3	3	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	15322733
	153	1431	5	None	-25	3	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@@H](N)C)OC	15322733
	6603801	1431	5	None	-25	3	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@@H](N)C)OC	15322733
	CHEMBL1434583	1431	5	None	-25	3	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@@H](N)C)OC	15322733
	1355	1980	82	None	-1	15	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	8450835
	142	1980	82	None	-1	15	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	8450835
	CHEMBL478	1980	82	None	-1	15	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	8450835
	DB12110	1980	82	None	-1	15	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	8450835
	102	4064	44	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10455251
	102	4064	44	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8078486
	102	4064	44	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
	3659	4064	44	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10455251
	3659	4064	44	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8078486
	3659	4064	44	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
	8969	4064	44	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10455251
	8969	4064	44	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8078486
	8969	4064	44	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
	CHEMBL15245	4064	44	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10455251
	CHEMBL15245	4064	44	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8078486
	CHEMBL15245	4064	44	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
	DB01392	4064	44	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10455251
	DB01392	4064	44	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8078486
	DB01392	4064	44	None	-93	49	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
	157	2038	5	None	-20	4	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	12954071
	9840090	2038	5	None	-20	4	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	12954071
	CHEMBL134519	2038	5	None	-20	4	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	12954071
	3652	4034	72	None	-2	18	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	57	4034	72	None	-2	18	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	60809	4034	72	None	-2	18	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	CHEMBL21536	4034	72	None	-2	18	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	DB15357	4034	72	None	-2	18	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	108029	3361	50	None	-15	13	Rat	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	8450835
	23	3361	50	None	-15	13	Rat	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	8450835
	CHEMBL18785	3361	50	None	-15	13	Rat	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	8450835
	13878025	2394	0	None	-19	2	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	342	3	2	4	2.4	CC(C(OC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C)O	8450835
	184	2394	0	None	-19	2	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	342	3	2	4	2.4	CC(C(OC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C)O	8450835
	CHEMBL52422	2394	0	None	-19	2	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	342	3	2	4	2.4	CC(C(OC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C)O	8450835
	1355	1980	82	None	-1	15	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	11104741
	1355	1980	82	None	-1	15	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	12970106
	1355	1980	82	None	-1	15	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	15322733
	1355	1980	82	None	-1	15	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	9459568
	1355	1980	82	None	-1	15	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	9933142
	142	1980	82	None	-1	15	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	11104741
	142	1980	82	None	-1	15	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	12970106
	142	1980	82	None	-1	15	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	15322733
	142	1980	82	None	-1	15	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	9459568
	142	1980	82	None	-1	15	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	9933142
	CHEMBL478	1980	82	None	-1	15	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	11104741
	CHEMBL478	1980	82	None	-1	15	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	12970106
	CHEMBL478	1980	82	None	-1	15	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	15322733
	CHEMBL478	1980	82	None	-1	15	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	9459568
	CHEMBL478	1980	82	None	-1	15	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	9933142
	DB12110	1980	82	None	-1	15	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	11104741
	DB12110	1980	82	None	-1	15	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	12970106
	DB12110	1980	82	None	-1	15	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	15322733
	DB12110	1980	82	None	-1	15	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	9459568
	DB12110	1980	82	None	-1	15	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	9933142
	5	139	66	None	-29	54	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8450835
	5202	139	66	None	-29	54	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8450835
	CHEMBL39	139	66	None	-29	54	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8450835
	DB08839	139	66	None	-29	54	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8450835
	107	141	116	None	-12	30	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8450835
	1833	141	116	None	-12	30	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8450835
	CHEMBL8165	141	116	None	-12	30	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8450835
	152	361	18	None	-1	18	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	8450835
	2107	361	18	None	-1	18	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	8450835
	CHEMBL275854	361	18	None	-1	18	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	8450835
	199	389	0	None	-5	4	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	8450835
	9821951	389	0	None	-5	4	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	8450835
	CHEMBL160293	389	0	None	-5	4	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	8450835
	216	2819	29	None	-	1	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	11104741
	9815618	2819	29	None	-	1	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	11104741
	CHEMBL253811	2819	29	None	-	1	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	11104741
	189	3436	31	None	-5	17	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	15322733
	189	3436	31	None	-5	17	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	15466450
	5163	3436	31	None	-5	17	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	15322733
	5163	3436	31	None	-5	17	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	15466450
	CHEMBL297784	3436	31	None	-5	17	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	15322733
	CHEMBL297784	3436	31	None	-5	17	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	15466450
	192	3446	46	None	-10	3	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	3	1	3	5.5	COc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cc(F)cc(c1)c1cccnc1	10188965
	192	3446	46	None	-10	3	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	3	1	3	5.5	COc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cc(F)cc(c1)c1cccnc1	10737744
	443390	3446	46	None	-10	3	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	3	1	3	5.5	COc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cc(F)cc(c1)c1cccnc1	10188965
	443390	3446	46	None	-10	3	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	3	1	3	5.5	COc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cc(F)cc(c1)c1cccnc1	10737744
	CHEMBL14276	3446	46	None	-10	3	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	3	1	3	5.5	COc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cc(F)cc(c1)c1cccnc1	10188965
	CHEMBL14276	3446	46	None	-10	3	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	3	1	3	5.5	COc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cc(F)cc(c1)c1cccnc1	10737744
	136	3240	28	None	-12	16	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
	223	3240	28	None	-12	16	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
	643606	3240	28	None	-12	16	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
	CHEMBL10347	3240	28	None	-12	16	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
	152	361	18	None	1	18	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	15322733
	152	361	18	None	1	18	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	15466450
	152	361	18	None	1	18	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	8078486
	2107	361	18	None	1	18	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	15322733
	2107	361	18	None	1	18	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	15466450
	2107	361	18	None	1	18	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	8078486
	CHEMBL275854	361	18	None	1	18	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	15322733
	CHEMBL275854	361	18	None	1	18	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	15466450
	CHEMBL275854	361	18	None	1	18	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	8078486
	5	139	66	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	11104741
	5	139	66	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	12954071
	5	139	66	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	15322733
	5	139	66	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	15466450
	5	139	66	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8078486
	5202	139	66	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	11104741
	5202	139	66	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	12954071
	5202	139	66	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	15322733
	5202	139	66	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	15466450
	5202	139	66	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8078486
	CHEMBL39	139	66	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	11104741
	CHEMBL39	139	66	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	12954071
	CHEMBL39	139	66	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	15322733
	CHEMBL39	139	66	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	15466450
	CHEMBL39	139	66	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8078486
	DB08839	139	66	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	11104741
	DB08839	139	66	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	12954071
	DB08839	139	66	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	15322733
	DB08839	139	66	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	15466450
	DB08839	139	66	None	-13	54	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8078486
	183	2392	0	None	-5	3	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	384	4	1	5	3.5	CC(C(O)C)OC(=O)[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C	8450835
	3034814	2392	0	None	-5	3	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	384	4	1	5	3.5	CC(C(O)C)OC(=O)[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C	8450835
	CHEMBL1356280	2392	0	None	-5	3	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	384	4	1	5	3.5	CC(C(O)C)OC(=O)[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C	8450835
	133	2460	48	None	-12	42	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8450835
	1723	2460	48	None	-12	42	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8450835
	28693	2460	48	None	-12	42	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8450835
	CHEMBL19215	2460	48	None	-12	42	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8450835
	DB13520	2460	48	None	-12	42	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8450835
	134	2478	19	None	-12	67	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8450835
	1775	2478	19	None	-12	67	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8450835
	9681	2478	19	None	-12	67	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8450835
	CHEMBL1065	2478	19	None	-12	67	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8450835
	DB00247	2478	19	None	-12	67	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8450835
	2105	3005	34	None	-28	33	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
	47811	3005	34	None	-28	33	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
	48	3005	34	None	-28	33	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
	CHEMBL531	3005	34	None	-28	33	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
	DB01186	3005	34	None	-28	33	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
	2601	3721	30	None	-8	21	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
	443951	3721	30	None	-8	21	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
	56	3721	30	None	-8	21	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
	CHEMBL73151	3721	30	None	-8	21	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
	DB13399	3721	30	None	-8	21	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
	10331436	321	7	None	-2	6	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	2.4	C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N	12954071
	160	321	7	None	-2	6	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	2.4	C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N	12954071
	CHEMBL133455	321	7	None	-2	6	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	2.4	C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N	12954071
	1621	2396	16	None	-39	44	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12213075
	17	2396	16	None	-39	44	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12213075
	5761	2396	16	None	-39	44	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12213075
	CHEMBL263881	2396	16	None	-39	44	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12213075
	DB04829	2396	16	None	-39	44	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12213075
	5074	3280	75	None	-9	29	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8450835
	97	3280	75	None	-9	29	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8450835
	CHEMBL267777	3280	75	None	-9	29	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8450835
	DB12693	3280	75	None	-9	29	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8450835
	10449757	3439	26	None	3	3	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10188965
	190	3439	26	None	3	3	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10188965
	CHEMBL2110371	3439	26	None	3	3	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10188965
	1342	36	42	None	-4	18	Rat	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8078486
	1342	36	42	None	-4	18	Rat	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8450835
	3	36	42	None	-4	18	Rat	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8078486
	3	36	42	None	-4	18	Rat	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8450835
	CHEMBL277120	36	42	None	-4	18	Rat	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8078486
	CHEMBL277120	36	42	None	-4	18	Rat	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8450835
	135398737	944	89	None	-2	91	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15322733
	135398737	944	89	None	-2	91	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9459568
	135398737	944	89	None	-2	91	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9732398
	38	944	89	None	-2	91	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15322733
	38	944	89	None	-2	91	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9459568
	38	944	89	None	-2	91	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9732398
	722	944	89	None	-2	91	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15322733
	722	944	89	None	-2	91	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9459568
	722	944	89	None	-2	91	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9732398
	CHEMBL42	944	89	None	-2	91	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15322733
	CHEMBL42	944	89	None	-2	91	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9459568
	CHEMBL42	944	89	None	-2	91	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9732398
	DB00363	944	89	None	-2	91	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15322733
	DB00363	944	89	None	-2	91	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9459568
	DB00363	944	89	None	-2	91	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9732398
	167	3376	0	None	-3	5	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	7	0	5	3.6	Fc1ccc(cc1)C(=O)CC1CCN(C1)CCOc1cccc2c1OCCO2	9732398
	9821498	3376	0	None	-3	5	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	7	0	5	3.6	Fc1ccc(cc1)C(=O)CC1CCN(C1)CCOc1cccc2c1OCCO2	9732398
	135409453	3714	38	None	2	2	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	15466450
	226	3714	38	None	2	2	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	15466450
	CHEMBL76370	3714	38	None	2	2	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	15466450
	191	3442	47	None	-1	3	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	15322733
	443389	3442	47	None	-1	3	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	15322733
	CHEMBL276140	3442	47	None	-1	3	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	15322733
	206	2457	10	None	-1	24	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	15107597
	206	2457	10	None	-1	24	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	15322733
	206	2457	10	None	-1	24	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	9459568
	68848	2457	10	None	-1	24	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	15107597
	68848	2457	10	None	-1	24	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	15322733
	68848	2457	10	None	-1	24	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	9459568
	CHEMBL12314	2457	10	None	-1	24	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	15107597
	CHEMBL12314	2457	10	None	-1	24	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	15322733
	CHEMBL12314	2457	10	None	-1	24	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	9459568
	1342	36	42	None	2	18	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8078486
	1342	36	42	None	2	18	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	9459568
	3	36	42	None	2	18	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8078486
	3	36	42	None	2	18	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	9459568
	CHEMBL277120	36	42	None	2	18	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8078486
	CHEMBL277120	36	42	None	2	18	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	9459568
	1043	1552	13	None	-22	28	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	11104741
	1043	1552	13	None	-22	28	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	15322733
	149	1552	13	None	-22	28	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	11104741
	149	1552	13	None	-22	28	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	15322733
	8223	1552	13	None	-22	28	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	11104741
	8223	1552	13	None	-22	28	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	15322733
	CHEMBL442	1552	13	None	-22	28	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	11104741
	CHEMBL442	1552	13	None	-22	28	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	15322733
	DB00696	1552	13	None	-22	28	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	11104741
	DB00696	1552	13	None	-22	28	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	15322733
	133	2460	48	None	-2	42	Human	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	15322733
	1723	2460	48	None	-2	42	Human	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	15322733
	28693	2460	48	None	-2	42	Human	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	15322733
	CHEMBL19215	2460	48	None	-2	42	Human	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	15322733
	DB13520	2460	48	None	-2	42	Human	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	15322733
	37	766	56	None	1	17	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
	460	766	56	None	1	17	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
	54746	766	56	None	1	17	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
	CHEMBL1201087	766	56	None	1	17	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
	DB00248	766	56	None	1	17	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
	1588	2294	24	None	-8	43	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
	28864	2294	24	None	-8	43	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
	43	2294	24	None	-8	43	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
	CHEMBL157138	2294	24	None	-8	43	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
	DB00589	2294	24	None	-8	43	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
	4106	2466	16	None	-3	33	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	15322733
	4106	2466	16	None	-3	33	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9459568
	5358812	2466	16	None	-3	33	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	15322733
	5358812	2466	16	None	-3	33	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9459568
	89	2466	16	None	-3	33	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	15322733
	89	2466	16	None	-3	33	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9459568
	CHEMBL93240	2466	16	None	-3	33	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	15322733
	CHEMBL93240	2466	16	None	-3	33	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9459568
	5074	3280	75	None	-3	29	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10188965
	5074	3280	75	None	-3	29	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10455251
	5074	3280	75	None	-3	29	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	15322733
	5074	3280	75	None	-3	29	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	9459568
	97	3280	75	None	-3	29	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10188965
	97	3280	75	None	-3	29	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10455251
	97	3280	75	None	-3	29	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	15322733
	97	3280	75	None	-3	29	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	9459568
	CHEMBL267777	3280	75	None	-3	29	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10188965
	CHEMBL267777	3280	75	None	-3	29	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10455251
	CHEMBL267777	3280	75	None	-3	29	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	15322733
	CHEMBL267777	3280	75	None	-3	29	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	9459568
	DB12693	3280	75	None	-3	29	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10188965
	DB12693	3280	75	None	-3	29	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10455251
	DB12693	3280	75	None	-3	29	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	15322733
	DB12693	3280	75	None	-3	29	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	9459568
	183	2392	0	None	5	3	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	384	4	1	5	3.5	CC(C(O)C)OC(=O)[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C	9459568
	3034814	2392	0	None	5	3	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	384	4	1	5	3.5	CC(C(O)C)OC(=O)[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C	9459568
	CHEMBL1356280	2392	0	None	5	3	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	384	4	1	5	3.5	CC(C(O)C)OC(=O)[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C	9459568
	154	2327	0	None	-1	4	Human	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	15322733
	638252	2327	0	None	-1	4	Human	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	15322733
	150	2473	18	None	1	15	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	11104741
	150	2473	18	None	1	15	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	15322733
	1764	2473	18	None	1	15	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	11104741
	1764	2473	18	None	1	15	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	15322733
	8226	2473	18	None	1	15	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	11104741
	8226	2473	18	None	1	15	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	15322733
	CHEMBL1201356	2473	18	None	1	15	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	11104741
	CHEMBL1201356	2473	18	None	1	15	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	15322733
	DB00353	2473	18	None	1	15	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	11104741
	DB00353	2473	18	None	1	15	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	15322733

Join us

Cite us

Main reference

Ligand source activities (1 row/activity)