Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
AssayType |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
| 49783414 | 17677 | 0 | None | - | 1 | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 320 | 7 | 1 | 5 | 2.9 | CCCCN1CCC(COC(=O)c2ccc(N)cc2OC)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258451 | 17677 | 0 | None | - | 1 | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 320 | 7 | 1 | 5 | 2.9 | CCCCN1CCC(COC(=O)c2ccc(N)cc2OC)CC1 | 10.1021/jm100668r | ||
| 53354764 | 3064 | 34 | None | 1 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 9059 | 3064 | 34 | None | 1 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| CHEMBL2152922 | 3064 | 34 | None | 1 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| DB12675 | 3064 | 34 | None | 1 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 53354764 | 3064 | 34 | None | 1 | 2 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 9059 | 3064 | 34 | None | 1 | 2 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| CHEMBL2152922 | 3064 | 34 | None | 1 | 2 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| DB12675 | 3064 | 34 | None | 1 | 2 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 53354764 | 3064 | 34 | None | 1 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 9059 | 3064 | 34 | None | 1 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| CHEMBL2152922 | 3064 | 34 | None | 1 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| DB12675 | 3064 | 34 | None | 1 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 11166796 | 82676 | 0 | None | 1 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179583 | 82676 | 0 | None | 1 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 11504722 | 76422 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 532 | 8 | 2 | 8 | 1.3 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059588 | 76422 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 532 | 8 | 2 | 8 | 1.3 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 44224237 | 194790 | 8 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL538635 | 194790 | 8 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 44224237 | 194790 | 8 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL538635 | 194790 | 8 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248189 91900499 | 194846 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 549 | 12 | 2 | 6 | 4.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCC[C@@H]2C(N)=O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL539713 | 194846 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 549 | 12 | 2 | 6 | 4.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCC[C@@H]2C(N)=O)cc2ccccc21 | 10.1021/jm900881j | ||
| 71712463 | 91390 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 465 | 9 | 3 | 6 | 1.4 | CC(C)c1nc2c(C(=O)NCC3CCN(CC(O)CN(C)S(C)(=O)=O)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402900 | 91390 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 465 | 9 | 3 | 6 | 1.4 | CC(C)c1nc2c(C(=O)NCC3CCN(CC(O)CN(C)S(C)(=O)=O)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| 53357011 | 82673 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 446 | 7 | 2 | 8 | 2.8 | O[C@@H]1CC[C@@H](Oc2cccc3onc(OCC4CCN(CC5(O)CCOCC5)CC4)c23)C1 | 10.1021/jm300953p | ||
| CHEMBL2179580 | 82673 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 446 | 7 | 2 | 8 | 2.8 | O[C@@H]1CC[C@@H](Oc2cccc3onc(OCC4CCN(CC5(O)CCOCC5)CC4)c23)C1 | 10.1021/jm300953p | ||
| 53354764 | 3064 | 34 | None | 1 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 9059 | 3064 | 34 | None | 1 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| CHEMBL2152922 | 3064 | 34 | None | 1 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| DB12675 | 3064 | 34 | None | 1 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 11350913 | 136795 | 2 | None | - | 1 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 430 | 5 | 2 | 7 | 2.2 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2ccccc21 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741376 | 136795 | 2 | None | - | 1 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 430 | 5 | 2 | 7 | 2.2 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2ccccc21 | 10.1016/j.ejmech.2015.08.051 | ||
| 11961293 | 3769 | 19 | None | - | 1 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.bmcl.2013.05.018 | ||
| 8426 | 3769 | 19 | None | - | 1 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402904 | 3769 | 19 | None | - | 1 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.bmcl.2013.05.018 | ||
| DB12725 | 3769 | 19 | None | - | 1 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.bmcl.2013.05.018 | ||
| 53354764 | 3064 | 34 | None | -1 | 2 | Rat | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 9059 | 3064 | 34 | None | -1 | 2 | Rat | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| CHEMBL2152922 | 3064 | 34 | None | -1 | 2 | Rat | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| DB12675 | 3064 | 34 | None | -1 | 2 | Rat | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 53354764 | 3064 | 34 | None | -1 | 2 | Rat | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 9059 | 3064 | 34 | None | -1 | 2 | Rat | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| CHEMBL2152922 | 3064 | 34 | None | -1 | 2 | Rat | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| DB12675 | 3064 | 34 | None | -1 | 2 | Rat | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 11842633 | 3981 | 21 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 10.1016/j.bmcl.2012.08.051 | ||
| 8425 | 3981 | 21 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087337 | 3981 | 21 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 10.1016/j.bmcl.2012.08.051 | ||
| 70686434 | 76417 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 560 | 10 | 3 | 8 | 2.0 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCC(CNS(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059583 | 76417 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 560 | 10 | 3 | 8 | 2.0 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCC(CNS(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 44248922 | 194900 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 627 | 14 | 2 | 7 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCC(CNS(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL540981 | 194900 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 627 | 14 | 2 | 7 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCC(CNS(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248319 | 195495 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 615 | 16 | 1 | 7 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN(C)CCCN(C)S(C)(=O)=O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL553404 | 195495 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 615 | 16 | 1 | 7 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN(C)CCCN(C)S(C)(=O)=O)cc2ccccc21 | 10.1021/jm900881j | ||
| 44247953 | 195818 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 581 | 12 | 2 | 5 | 6.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN(C)CCc2c[nH]c3ccccc23)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL558163 | 195818 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 581 | 12 | 2 | 5 | 6.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN(C)CCc2c[nH]c3ccccc23)cc2ccccc21 | 10.1021/jm900881j | ||
| 71714541 | 91381 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 520 | 9 | 3 | 7 | 1.1 | CC(C)c1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402891 | 91381 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 520 | 9 | 3 | 7 | 1.1 | CC(C)c1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| 71714542 | 91382 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 518 | 9 | 3 | 7 | 0.8 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(CNC(=O)c3cccc4[nH]c(C5CC5)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402892 | 91382 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 518 | 9 | 3 | 7 | 0.8 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(CNC(=O)c3cccc4[nH]c(C5CC5)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 53354764 | 3064 | 34 | None | -1 | 2 | Rat | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 9059 | 3064 | 34 | None | -1 | 2 | Rat | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| CHEMBL2152922 | 3064 | 34 | None | -1 | 2 | Rat | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| DB12675 | 3064 | 34 | None | -1 | 2 | Rat | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 70694780 | 76416 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 509 | 12 | 1 | 6 | 5.0 | COC[C@@H]1CCCN1CCCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059582 | 76416 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 509 | 12 | 1 | 6 | 5.0 | COC[C@@H]1CCCN1CCCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | ||
| 11606227 | 76419 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 532 | 8 | 2 | 8 | 1.3 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059585 | 76419 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 532 | 8 | 2 | 8 | 1.3 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 11627949 | 76421 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 532 | 8 | 2 | 8 | 1.3 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@H](O)CN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059587 | 76421 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 532 | 8 | 2 | 8 | 1.3 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@H](O)CN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 44248921 | 195246 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 520 | 11 | 1 | 5 | 5.7 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL551013 | 195246 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 520 | 11 | 1 | 5 | 5.7 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248186 | 195461 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 567 | 15 | 3 | 5 | 6.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN(C)CCc2c[nH]c3ccccc23)CC1 | 10.1021/jm900881j | ||
| CHEMBL552484 | 195461 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 567 | 15 | 3 | 5 | 6.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN(C)CCc2c[nH]c3ccccc23)CC1 | 10.1021/jm900881j | ||
| 11519716 | 195496 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL553405 | 195496 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248321 | 195581 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 541 | 8 | 1 | 6 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCN(c3ccccc3)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL555222 | 195581 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 541 | 8 | 1 | 6 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCN(c3ccccc3)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 71714544 | 91384 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 542 | 9 | 3 | 7 | 1.1 | CC(F)(F)c1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402894 | 91384 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 542 | 9 | 3 | 7 | 1.1 | CC(F)(F)c1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| 71712327 | 91387 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 490 | 8 | 2 | 6 | 1.7 | CC(C)c1nc2c(C(=O)NCC3CCN(CCN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402897 | 91387 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 490 | 8 | 2 | 6 | 1.7 | CC(C)c1nc2c(C(=O)NCC3CCN(CCN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| 71451950 | 82675 | 8 | None | 1 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179582 | 82675 | 8 | None | 1 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 71450132 | 82677 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 358 | 8 | 0 | 5 | 4.7 | CCCCN1CCC(COc2noc3cccc(OC4CCC4)c23)CC1 | 10.1021/jm300953p | ||
| CHEMBL2179584 | 82677 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 358 | 8 | 0 | 5 | 4.7 | CCCCN1CCC(COc2noc3cccc(OC4CCC4)c23)CC1 | 10.1021/jm300953p | ||
| 71451950 | 82675 | 8 | None | 1 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179582 | 82675 | 8 | None | 1 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 11166796 | 82676 | 0 | None | 1 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179583 | 82676 | 0 | None | 1 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 11166796 | 82676 | 0 | None | -1 | 2 | Rat | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179583 | 82676 | 0 | None | -1 | 2 | Rat | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 11166796 | 82676 | 0 | None | -1 | 2 | Rat | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179583 | 82676 | 0 | None | -1 | 2 | Rat | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 53357029 | 82682 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 418 | 8 | 1 | 7 | 3.5 | CC(C)COc1cccc2onc(OCC3CCN(CC4(O)CCOCC4)CC3)c12 | 10.1021/jm300953p | ||
| CHEMBL2179589 | 82682 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 418 | 8 | 1 | 7 | 3.5 | CC(C)COc1cccc2onc(OCC3CCN(CC4(O)CCOCC4)CC3)c12 | 10.1021/jm300953p | ||
| 11166796 | 82676 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179583 | 82676 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 135409453 | 3773 | 41 | None | 28 | 35 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.05.034 | ||
| 226 | 3773 | 41 | None | 28 | 35 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL76370 | 3773 | 41 | None | 28 | 35 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.05.034 | ||
| 44248435 | 195580 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 623 | 15 | 2 | 5 | 7.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN(C)CCc2c[nH]c3ccccc23)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL555210 | 195580 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 623 | 15 | 2 | 5 | 7.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN(C)CCc2c[nH]c3ccccc23)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248680 | 195582 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 571 | 10 | 2 | 7 | 3.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCC(CNS(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL555223 | 195582 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 571 | 10 | 2 | 7 | 3.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCC(CNS(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248313 91900492 | 195864 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 492 | 9 | 1 | 5 | 5.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL558719 | 195864 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 492 | 9 | 1 | 5 | 5.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 71714540 | 91380 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 506 | 9 | 3 | 7 | 0.5 | CCc1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402890 | 91380 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 506 | 9 | 3 | 7 | 0.5 | CCc1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| 66810955 | 91393 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 475 | 7 | 2 | 5 | 2.8 | CC(C)c1nc2c(C(=O)NCC3CCN(CC4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402903 | 91393 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 475 | 7 | 2 | 5 | 2.8 | CC(C)c1nc2c(C(=O)NCC3CCN(CC4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| 71462650 | 82679 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 372 | 9 | 0 | 5 | 4.9 | CCCCN1CCC(COc2noc3cccc(OCC4CCC4)c23)CC1 | 10.1021/jm300953p | ||
| CHEMBL2179586 | 82679 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 372 | 9 | 0 | 5 | 4.9 | CCCCN1CCC(COc2noc3cccc(OCC4CCC4)c23)CC1 | 10.1021/jm300953p | ||
| 71451950 | 82675 | 8 | None | -1 | 2 | Rat | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179582 | 82675 | 8 | None | -1 | 2 | Rat | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 11166796 | 82676 | 0 | None | 1 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179583 | 82676 | 0 | None | 1 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 71451951 | 82678 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 372 | 8 | 0 | 5 | 5.0 | CCCCN1CCC(COc2noc3cccc(OC4CCCC4)c23)CC1 | 10.1021/jm300953p | ||
| CHEMBL2179585 | 82678 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 372 | 8 | 0 | 5 | 5.0 | CCCCN1CCC(COc2noc3cccc(OC4CCCC4)c23)CC1 | 10.1021/jm300953p | ||
| 71462651 | 82680 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 360 | 9 | 0 | 5 | 4.8 | CCCCN1CCC(COc2noc3cccc(OCC(C)C)c23)CC1 | 10.1021/jm300953p | ||
| CHEMBL2179587 | 82680 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 360 | 9 | 0 | 5 | 4.8 | CCCCN1CCC(COc2noc3cccc(OCC(C)C)c23)CC1 | 10.1021/jm300953p | ||
| 71451950 | 82675 | 8 | None | 1 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179582 | 82675 | 8 | None | 1 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 44247820 91900493 | 194799 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 534 | 12 | 1 | 5 | 6.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL538706 | 194799 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 534 | 12 | 1 | 5 | 6.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44247951 91900497 | 194912 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 539 | 9 | 2 | 5 | 5.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN(C)CCc2c[nH]c3ccccc23)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL541223 | 194912 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 539 | 9 | 2 | 5 | 5.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN(C)CCc2c[nH]c3ccccc23)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248923 | 194936 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL541968 | 194936 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44247822 91900495 | 195515 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 571 | 10 | 1 | 7 | 3.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL553685 | 195515 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 571 | 10 | 1 | 7 | 3.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248184 | 196162 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 525 | 12 | 3 | 5 | 5.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN(C)CCc2c[nH]c3ccccc23)CC1 | 10.1021/jm900881j | ||
| CHEMBL561278 | 196162 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 525 | 12 | 3 | 5 | 5.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN(C)CCc2c[nH]c3ccccc23)CC1 | 10.1021/jm900881j | ||
| 71451950 | 82675 | 8 | None | 1 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179582 | 82675 | 8 | None | 1 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 53354764 | 3064 | 34 | None | 1 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1016/j.ejmech.2015.08.051 | ||
| 9059 | 3064 | 34 | None | 1 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL2152922 | 3064 | 34 | None | 1 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1016/j.ejmech.2015.08.051 | ||
| DB12675 | 3064 | 34 | None | 1 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1016/j.ejmech.2015.08.051 | ||
| 155565664 | 175603 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 432 | 8 | 2 | 6 | 4.5 | COc1ccc(CN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1O | 10.1016/j.ejmech.2019.111596 | ||
| CHEMBL4580044 | 175603 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 432 | 8 | 2 | 6 | 4.5 | COc1ccc(CN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1O | 10.1016/j.ejmech.2019.111596 | ||
| 11493559 | 73413 | 0 | None | - | 1 | Rat | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 324 | 4 | 1 | 5 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)OC[C@@H]1CCN2CCC[C@@H]12 | 10.1021/jm0509501 | ||
| CHEMBL201621 | 73413 | 0 | None | - | 1 | Rat | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 324 | 4 | 1 | 5 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)OC[C@@H]1CCN2CCC[C@@H]12 | 10.1021/jm0509501 | ||
| 11961293 | 3769 | 19 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.ejmech.2015.08.051 | ||
| 8426 | 3769 | 19 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL2402904 | 3769 | 19 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.ejmech.2015.08.051 | ||
| DB12725 | 3769 | 19 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.ejmech.2015.08.051 | ||
| 71451950 | 82675 | 8 | None | -1 | 2 | Rat | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179582 | 82675 | 8 | None | -1 | 2 | Rat | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 70688535 | 76418 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 586 | 13 | 2 | 7 | 4.2 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCN2CCC(CNS(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059584 | 76418 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 586 | 13 | 2 | 7 | 4.2 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCN2CCC(CNS(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 44248076 | 195044 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 543 | 8 | 1 | 7 | 2.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL549449 | 195044 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 543 | 8 | 1 | 7 | 2.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 71712466 | 91241 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 439 | 6 | 2 | 4 | 3.4 | CC(=O)N1CCC(CN2CCC(CNC(=O)c3cccc4[nH]c(C(C)C)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2401750 | 91241 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 439 | 6 | 2 | 4 | 3.4 | CC(=O)N1CCC(CN2CCC(CNC(=O)c3cccc4[nH]c(C(C)C)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 71712325 | 91385 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 554 | 9 | 3 | 7 | 1.6 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(CNC(=O)c3cccc4[nH]c(-c5ccccc5)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402895 | 91385 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 554 | 9 | 3 | 7 | 1.6 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(CNC(=O)c3cccc4[nH]c(-c5ccccc5)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 71712328 | 91388 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 470 | 7 | 2 | 6 | 2.5 | COC(=O)N1CCN(CCN2CCC(CNC(=O)c3cccc4[nH]c(C(C)C)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402898 | 91388 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 470 | 7 | 2 | 6 | 2.5 | COC(=O)N1CCN(CCN2CCC(CNC(=O)c3cccc4[nH]c(C(C)C)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 71712465 | 91392 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 429 | 8 | 3 | 5 | 2.0 | CC(=O)N(C)CC(O)CN1CCC(CNC(=O)c2cccc3[nH]c(C(C)C)nc23)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402902 | 91392 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 429 | 8 | 3 | 5 | 2.0 | CC(=O)N(C)CC(O)CN1CCC(CNC(=O)c2cccc3[nH]c(C(C)C)nc23)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 11166796 | 82676 | 0 | None | -1 | 2 | Rat | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179583 | 82676 | 0 | None | -1 | 2 | Rat | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 71462652 | 82683 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 434 | 8 | 2 | 8 | 2.6 | CC(C)(O)COc1cccc2onc(OCC3CCN(CC4(O)CCOCC4)CC3)c12 | 10.1021/jm300953p | ||
| CHEMBL2179590 | 82683 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 434 | 8 | 2 | 8 | 2.6 | CC(C)(O)COc1cccc2onc(OCC3CCN(CC4(O)CCOCC4)CC3)c12 | 10.1021/jm300953p | ||
| 9952994 | 106970 | 0 | None | - | 1 | Rat | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 366 | 6 | 1 | 5 | 3.5 | CCCCN1CCC(COC(=O)c2cc(Cl)c(N)c3c2OCC3)CC1 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL315071 | 106970 | 0 | None | - | 1 | Rat | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 366 | 6 | 1 | 5 | 3.5 | CCCCN1CCC(COC(=O)c2cc(Cl)c(N)c3c2OCC3)CC1 | 10.1016/0960-894X(96)00002-9 | ||
| 53357016 | 82674 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 446 | 7 | 1 | 8 | 3.0 | OC1(CN2CCC(COc3noc4cccc(OC5CCOCC5)c34)CC2)CCOCC1 | 10.1021/jm300953p | ||
| CHEMBL2179581 | 82674 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 446 | 7 | 1 | 8 | 3.0 | OC1(CN2CCC(COc3noc4cccc(OC5CCOCC5)c34)CC2)CCOCC1 | 10.1021/jm300953p | ||
| 70682173 | 76411 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 453 | 7 | 2 | 6 | 3.2 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCCCC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059577 | 76411 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 453 | 7 | 2 | 6 | 3.2 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCCCC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 44248439 | 196192 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 464 | 7 | 1 | 5 | 4.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL561398 | 196192 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 464 | 7 | 1 | 5 | 4.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 135409453 | 3773 | 41 | None | 28 | 35 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.05.034 | ||
| 226 | 3773 | 41 | None | 28 | 35 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL76370 | 3773 | 41 | None | 28 | 35 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.05.034 | ||
| 44224237 | 194790 | 8 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL538635 | 194790 | 8 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 71712464 | 91391 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 445 | 8 | 3 | 6 | 2.2 | COC(=O)N(C)CC(O)CN1CCC(CNC(=O)c2cccc3[nH]c(C(C)C)nc23)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402901 | 91391 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 445 | 8 | 3 | 6 | 2.2 | COC(=O)N(C)CC(O)CN1CCC(CNC(=O)c2cccc3[nH]c(C(C)C)nc23)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 44224237 | 194790 | 8 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL538635 | 194790 | 8 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| 19081984 | 205954 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 336 | 7 | 1 | 4 | 3.8 | C=CCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL84398 | 205954 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 336 | 7 | 1 | 4 | 3.8 | C=CCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1016/S0960-894X(01)80413-3 | ||
| 49783210 | 17639 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 440 | 7 | 1 | 6 | 3.9 | CCCCN1CCC(COC(=O)c2cc(Br)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258338 | 17639 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 440 | 7 | 1 | 6 | 3.9 | CCCCN1CCC(COC(=O)c2cc(Br)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| 10837280 91900491 | 195822 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 450 | 6 | 1 | 5 | 3.8 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL558259 | 195822 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 450 | 6 | 1 | 5 | 3.8 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248317 | 195899 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 559 | 12 | 1 | 7 | 2.9 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN(C)CCCN(C)S(C)(=O)=O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL559050 | 195899 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 559 | 12 | 1 | 7 | 2.9 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN(C)CCCN(C)S(C)(=O)=O)cc2ccccc21 | 10.1021/jm900881j | ||
| 11225102 | 76424 | 3 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 466 | 6 | 1 | 6 | 2.5 | CC(=O)N1CCN(CCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2nn(C(C)C)c4ccccc24)C3)CC1 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059590 | 76424 | 3 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 466 | 6 | 1 | 6 | 2.5 | CC(=O)N1CCN(CCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2nn(C(C)C)c4ccccc24)C3)CC1 | 10.1016/j.bmcl.2012.05.034 | ||
| 127039167 | 136821 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 398 | 6 | 1 | 5 | 3.3 | CC(C)c1nc(C(=O)NCC2CCN(CC3CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741608 | 136821 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 398 | 6 | 1 | 5 | 3.3 | CC(C)c1nc(C(=O)NCC2CCN(CC3CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 71712611 | 91377 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 478 | 8 | 3 | 7 | -0.1 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(CNC(=O)c3cccc4[nH]cnc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402887 | 91377 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 478 | 8 | 3 | 7 | -0.1 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(CNC(=O)c3cccc4[nH]cnc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 11225102 | 76424 | 3 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 466 | 6 | 1 | 6 | 2.5 | CC(=O)N1CCN(CCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2nn(C(C)C)c4ccccc24)C3)CC1 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2059590 | 76424 | 3 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 466 | 6 | 1 | 6 | 2.5 | CC(=O)N1CCN(CCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2nn(C(C)C)c4ccccc24)C3)CC1 | 10.1016/j.bmcl.2012.08.051 | ||
| 70684790 | 77507 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 484 | 7 | 2 | 7 | 2.4 | COC(=O)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087333 | 77507 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 484 | 7 | 2 | 7 | 2.4 | COC(=O)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| 11432106 | 77509 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN(C)S(C)(=O)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087335 | 77509 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN(C)S(C)(=O)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| 71462777 | 82965 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 335 | 5 | 0 | 4 | 4.3 | CCCN1CCC(COc2nc3ccccc3c3ncccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181171 | 82965 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 335 | 5 | 0 | 4 | 4.3 | CCCN1CCC(COc2nc3ccccc3c3ncccc23)CC1 | 10.1021/jm300943r | ||
| 130946 | 202758 | 2 | None | - | 1 | Rat | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 328 | 2 | 1 | 5 | 2.0 | CCn1c(=O)n(C(=O)NC2CC3CCC(C2)N3C)c2ccccc21 | 10.1016/S0960-894X(01)81243-9 | ||
| CHEMBL62023 | 202758 | 2 | None | - | 1 | Rat | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 328 | 2 | 1 | 5 | 2.0 | CCn1c(=O)n(C(=O)NC2CC3CCC(C2)N3C)c2ccccc21 | 10.1016/S0960-894X(01)81243-9 | ||
| 5 | 139 | 72 | None | -138 | 26 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1038/nature05991 | ||
| 5202 | 139 | 72 | None | -138 | 26 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1038/nature05991 | ||
| CHEMBL39 | 139 | 72 | None | -138 | 26 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1038/nature05991 | ||
| DB08839 | 139 | 72 | None | -138 | 26 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1038/nature05991 | ||
| 44249186 | 195316 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 327 | 4 | 2 | 4 | 2.3 | CC(C)n1c(=O)c(C(=O)NCC2CCNCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL551535 | 195316 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 327 | 4 | 2 | 4 | 2.3 | CC(C)n1c(=O)c(C(=O)NCC2CCNCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 15231247 91900477 | 195652 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 309 | 3 | 3 | 4 | 1.9 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1C[C@@H]2CC[C@H](C1)N2 | 10.1021/jm900881j | ||
| CHEMBL556438 | 195652 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 309 | 3 | 3 | 4 | 1.9 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1C[C@@H]2CC[C@H](C1)N2 | 10.1021/jm900881j | ||
| 44249053 | 196501 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 394 | 6 | 2 | 5 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN2CCCCC2)CC1 | 10.1021/jm900881j | ||
| CHEMBL563445 | 196501 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 394 | 6 | 2 | 5 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN2CCCCC2)CC1 | 10.1021/jm900881j | ||
| 44247949 | 195114 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | 475 | 12 | 3 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCS(=O)(=O)O)CC1 | 10.1021/jm900881j | ||
| CHEMBL549998 | 195114 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | 475 | 12 | 3 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCS(=O)(=O)O)CC1 | 10.1021/jm900881j | ||
| 127037817 | 136608 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 382 | 5 | 1 | 5 | 2.5 | CC(C)c1nc(C(=O)NC2C3CN(CC4CCOCC4)CC32)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3739689 | 136608 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 382 | 5 | 1 | 5 | 2.5 | CC(C)c1nc(C(=O)NC2C3CN(CC4CCOCC4)CC32)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 127041480 | 136627 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 384 | 5 | 1 | 5 | 3.1 | CC(C)c1nc(C(=O)NCC2CCN(C3CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3739862 | 136627 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 384 | 5 | 1 | 5 | 3.1 | CC(C)c1nc(C(=O)NCC2CCN(C3CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 44323264 | 207112 | 0 | None | - | 1 | Rat | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 322 | 2 | 1 | 5 | 2.1 | Nc1c(Cl)cc(C(=O)O[C@@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL92100 | 207112 | 0 | None | - | 1 | Rat | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 322 | 2 | 1 | 5 | 2.1 | Nc1c(Cl)cc(C(=O)O[C@@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| 5 | 139 | 72 | None | -138 | 26 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm801327q | ||
| 5202 | 139 | 72 | None | -138 | 26 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm801327q | ||
| CHEMBL39 | 139 | 72 | None | -138 | 26 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm801327q | ||
| DB08839 | 139 | 72 | None | -138 | 26 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm801327q | ||
| 3037881 | 99745 | 1 | None | - | 1 | Rat | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 355 | 1 | 1 | 4 | 2.8 | Nc1c(Cl)cc2c3c(cccc13)C(=O)N([C@@H]1CN3CCC1CC3)C2=O | 10.1016/S0960-894X(00)80352-2 | ||
| CHEMBL28499 | 99745 | 1 | None | - | 1 | Rat | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 355 | 1 | 1 | 4 | 2.8 | Nc1c(Cl)cc2c3c(cccc13)C(=O)N([C@@H]1CN3CCC1CC3)C2=O | 10.1016/S0960-894X(00)80352-2 | ||
| 19081885 | 205344 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 338 | 7 | 1 | 4 | 4.0 | CCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL79637 | 205344 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 338 | 7 | 1 | 4 | 4.0 | CCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1016/S0960-894X(01)80413-3 | ||
| 257 | 3493 | 13 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 474 | 6 | 1 | 6 | 3.3 | CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N | 10.1021/jm100668r | ||
| 5311423 | 3493 | 13 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 474 | 6 | 1 | 6 | 3.3 | CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N | 10.1021/jm100668r | ||
| CHEMBL114112 | 3493 | 13 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 474 | 6 | 1 | 6 | 3.3 | CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N | 10.1021/jm100668r | ||
| 70684288 | 76420 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 558 | 11 | 1 | 7 | 3.5 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059586 | 76420 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 558 | 11 | 1 | 7 | 3.5 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 44248793 91900478 | 195623 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 339 | 3 | 2 | 4 | 2.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL556235 | 195623 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 339 | 3 | 2 | 4 | 2.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248068 | 195885 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 515 | 10 | 2 | 7 | 1.9 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN2CCN(S(C)(=O)=O)CC2)CC1 | 10.1021/jm900881j | ||
| CHEMBL558924 | 195885 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 515 | 10 | 2 | 7 | 1.9 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN2CCN(S(C)(=O)=O)CC2)CC1 | 10.1021/jm900881j | ||
| 44247817 91900489 | 195975 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 489 | 9 | 2 | 6 | 3.4 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCS(=O)(=O)O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL559746 | 195975 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 489 | 9 | 2 | 6 | 3.4 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCS(=O)(=O)O)cc2ccccc21 | 10.1021/jm900881j | ||
| 67276147 | 77499 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 468 | 7 | 2 | 6 | 2.1 | CC(=O)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087325 | 77499 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 468 | 7 | 2 | 6 | 2.1 | CC(=O)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| 70695322 | 77502 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 469 | 7 | 4 | 6 | 1.6 | CNC(=O)NCC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087328 | 77502 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 469 | 7 | 4 | 6 | 1.6 | CNC(=O)NCC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| 131725 | 200437 | 3 | None | - | 1 | Rat | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 342 | 2 | 1 | 5 | 2.6 | CC(C)n1c(=O)n(C(=O)NC2CC3CCC(C2)N3C)c2ccccc21 | 10.1016/S0960-894X(01)81243-9 | ||
| CHEMBL59834 | 200437 | 3 | None | - | 1 | Rat | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 342 | 2 | 1 | 5 | 2.6 | CC(C)n1c(=O)n(C(=O)NC2CC3CCC(C2)N3C)c2ccccc21 | 10.1016/S0960-894X(01)81243-9 | ||
| 44626295 | 197774 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 531 | 8 | 3 | 7 | 3.8 | COc1cccc([C@]2(O)CCCC[C@H]2CN2CC[C@@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@@H](OC)C2)c1 | 10.1016/j.bmcl.2009.08.016 | ||
| CHEMBL571799 | 197774 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 531 | 8 | 3 | 7 | 3.8 | COc1cccc([C@]2(O)CCCC[C@H]2CN2CC[C@@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@@H](OC)C2)c1 | 10.1016/j.bmcl.2009.08.016 | ||
| 44461665 | 104548 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 325 | 6 | 2 | 4 | 2.5 | COc1cc(N)c(Cl)cc1C(=O)NCCCN1CCCCC1 | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL310451 | 104548 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 325 | 6 | 2 | 4 | 2.5 | COc1cc(N)c(Cl)cc1C(=O)NCCCN1CCCCC1 | 10.1016/S0960-894X(01)80413-3 | ||
| 9882676 | 205760 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 296 | 5 | 2 | 4 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCNCC1 | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL82833 | 205760 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 296 | 5 | 2 | 4 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCNCC1 | 10.1016/S0960-894X(01)80413-3 | ||
| 11496400 | 11808 | 0 | None | - | 1 | Rat | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 338 | 4 | 2 | 3 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CC[N@@+]2(C)CCC[C@@H]12 | 10.1021/jm0509501 | ||
| CHEMBL1181946 | 11808 | 0 | None | - | 1 | Rat | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 338 | 4 | 2 | 3 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CC[N@@+]2(C)CCC[C@@H]12 | 10.1021/jm0509501 | ||
| CHEMBL199866 | 11808 | 0 | None | - | 1 | Rat | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 338 | 4 | 2 | 3 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CC[N@@+]2(C)CCC[C@@H]12 | 10.1021/jm0509501 | ||
| 127039820 | 136778 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 366 | 6 | 1 | 4 | 3.2 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(CC4CCC4)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741224 | 136778 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 366 | 6 | 1 | 4 | 3.2 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(CC4CCC4)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 127039507 | 136870 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 360 | 5 | 1 | 4 | 3.4 | CC(C)c1nc(C(=O)NC2CCN(CC(C)(C)F)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3742086 | 136870 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 360 | 5 | 1 | 4 | 3.4 | CC(C)c1nc(C(=O)NC2CCN(CC(C)(C)F)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 127041780 | 136677 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 416 | 6 | 1 | 5 | 3.4 | CC(C)c1nc(C(=O)NCC2(F)CCN(CC3CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740278 | 136677 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 416 | 6 | 1 | 5 | 3.4 | CC(C)c1nc(C(=O)NCC2(F)CCN(CC3CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 44323269 | 12072 | 0 | None | - | 1 | Rat | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 378 | 5 | 2 | 3 | 3.0 | CCCC[N+]12CCC(CC1)[C@@H](NC(=O)c1cc(Cl)c(N)c3c1OCC3)C2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL1183709 | 12072 | 0 | None | - | 1 | Rat | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 378 | 5 | 2 | 3 | 3.0 | CCCC[N+]12CCC(CC1)[C@@H](NC(=O)c1cc(Cl)c(N)c3c1OCC3)C2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL314198 | 12072 | 0 | None | - | 1 | Rat | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 378 | 5 | 2 | 3 | 3.0 | CCCC[N+]12CCC(CC1)[C@@H](NC(=O)c1cc(Cl)c(N)c3c1OCC3)C2 | 10.1016/0960-894X(96)00002-9 | ||
| 49783209 | 17609 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 396 | 7 | 1 | 6 | 3.8 | CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258223 | 17609 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 396 | 7 | 1 | 6 | 3.8 | CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| 127042086 | 136718 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 400 | 5 | 2 | 6 | 2.2 | CC(C)c1nc(C(=O)NC2CCN(CC3(O)CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740708 | 136718 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 400 | 5 | 2 | 6 | 2.2 | CC(C)c1nc(C(=O)NC2CCN(CC3(O)CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 127042083 | 136883 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 344 | 6 | 1 | 5 | 2.3 | COCCN1CCC(NC(=O)c2nc(C(C)C)n3ccccc23)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3742190 | 136883 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 344 | 6 | 1 | 5 | 2.3 | COCCN1CCC(NC(=O)c2nc(C(C)C)n3ccccc23)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| 127041784 | 136845 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 354 | 5 | 1 | 4 | 3.5 | CC(C)c1nc(C(=O)NC2CCN(CC3CCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741826 | 136845 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 354 | 5 | 1 | 4 | 3.5 | CC(C)c1nc(C(=O)NC2CCN(CC3CCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 19081860 | 205699 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 324 | 6 | 1 | 4 | 3.6 | CCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL82360 | 205699 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 324 | 6 | 1 | 4 | 3.6 | CCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1016/S0960-894X(01)80413-3 | ||
| 49783212 | 17676 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 387 | 7 | 1 | 7 | 3.0 | CCCCN1CCC(COC(=O)c2cc(C#N)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258450 | 17676 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 387 | 7 | 1 | 7 | 3.0 | CCCCN1CCC(COC(=O)c2cc(C#N)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| 44249316 91900479 | 195352 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 328 | 2 | 2 | 5 | 2.2 | CC(C)n1c(=O)n(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)c2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL551820 | 195352 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 328 | 2 | 2 | 5 | 2.2 | CC(C)n1c(=O)n(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)c2ccccc21 | 10.1021/jm900881j | ||
| 44247811 | 195471 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 369 | 8 | 3 | 5 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCO)CC1 | 10.1021/jm900881j | ||
| CHEMBL552693 | 195471 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 369 | 8 | 3 | 5 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCO)CC1 | 10.1021/jm900881j | ||
| 44247813 | 195592 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 411 | 11 | 3 | 5 | 3.5 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCO)CC1 | 10.1021/jm900881j | ||
| CHEMBL555447 | 195592 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 411 | 11 | 3 | 5 | 3.5 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCO)CC1 | 10.1021/jm900881j | ||
| 44248072 | 195675 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 483 | 9 | 3 | 5 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN(C)CCc2c[nH]c3ccccc23)CC1 | 10.1021/jm900881j | ||
| CHEMBL556595 | 195675 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 483 | 9 | 3 | 5 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN(C)CCc2c[nH]c3ccccc23)CC1 | 10.1021/jm900881j | ||
| 44249057 91900485 | 196099 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 467 | 11 | 2 | 5 | 4.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCO)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL560876 | 196099 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 467 | 11 | 2 | 5 | 4.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCO)cc2ccccc21 | 10.1021/jm900881j | ||
| 44249188 | 196112 | 1 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 316 | 3 | 2 | 5 | 1.9 | CC(C)n1c(=O)n(C(=O)NCC2CCNCC2)c2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL560940 | 196112 | 1 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 316 | 3 | 2 | 5 | 1.9 | CC(C)n1c(=O)n(C(=O)NCC2CCNCC2)c2ccccc21 | 10.1021/jm900881j | ||
| 44249311 | 195326 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 313 | 3 | 2 | 4 | 2.1 | CC(C)n1c(=O)c(C(=O)NC2CCNCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL551614 | 195326 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 313 | 3 | 2 | 4 | 2.1 | CC(C)n1c(=O)c(C(=O)NC2CCNCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44247945 | 196070 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 391 | 6 | 3 | 6 | 1.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCS(=O)(=O)O)CC1 | 10.1021/jm900881j | ||
| CHEMBL560597 | 196070 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 391 | 6 | 3 | 6 | 1.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCS(=O)(=O)O)CC1 | 10.1021/jm900881j | ||
| 132337 | 3543 | 15 | None | -1 | 2 | Rat | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1021/jm0509501 | ||
| 238 | 3543 | 15 | None | -1 | 2 | Rat | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1021/jm0509501 | ||
| CHEMBL34291 | 3543 | 15 | None | -1 | 2 | Rat | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1021/jm0509501 | ||
| 44308599 | 203700 | 0 | None | - | 1 | Rat | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 349 | 5 | 2 | 4 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)NCCC12CC3CN(CC3C1)C2 | 10.1016/S0960-894X(97)00408-3 | ||
| CHEMBL67554 | 203700 | 0 | None | - | 1 | Rat | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 349 | 5 | 2 | 4 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)NCCC12CC3CN(CC3C1)C2 | 10.1016/S0960-894X(97)00408-3 | ||
| 54677674 | 112809 | 4 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3291085 | 112809 | 4 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3306918 | 112809 | 4 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1016/j.ejmech.2015.08.051 | ||
| 5 | 139 | 72 | None | -29 | 26 | Rat | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/0960-894X(96)00002-9 | ||
| 5202 | 139 | 72 | None | -29 | 26 | Rat | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL39 | 139 | 72 | None | -29 | 26 | Rat | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/0960-894X(96)00002-9 | ||
| DB08839 | 139 | 72 | None | -29 | 26 | Rat | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/0960-894X(96)00002-9 | ||
| 42618248 | 187028 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 479 | 8 | 2 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)Cc2ccccc2Cl)CC1 | 10.1021/jm801327q | ||
| CHEMBL490852 | 187028 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 479 | 8 | 2 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)Cc2ccccc2Cl)CC1 | 10.1021/jm801327q | ||
| 127039821 | 136634 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 352 | 5 | 1 | 4 | 2.9 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(C4CCC4)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3739931 | 136634 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 352 | 5 | 1 | 4 | 2.9 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(C4CCC4)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 127039374 | 136819 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 372 | 6 | 1 | 4 | 3.1 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(CC(C)(C)F)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741595 | 136819 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 372 | 6 | 1 | 4 | 3.1 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(CC(C)(C)F)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 127039822 | 136733 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 340 | 5 | 1 | 4 | 2.8 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(C(C)C)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740844 | 136733 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 340 | 5 | 1 | 4 | 2.8 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(C(C)C)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 9905225 | 206944 | 0 | None | - | 1 | Rat | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 321 | 2 | 2 | 4 | 1.7 | Nc1c(Cl)cc(C(=O)N[C@@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL91147 | 206944 | 0 | None | - | 1 | Rat | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 321 | 2 | 2 | 4 | 1.7 | Nc1c(Cl)cc(C(=O)N[C@@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| 9927789 | 111502 | 0 | None | - | 1 | Rat | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 337 | 5 | 2 | 4 | 2.5 | Nc1c(Cl)cc(C(=O)NCCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL327798 | 111502 | 0 | None | - | 1 | Rat | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 337 | 5 | 2 | 4 | 2.5 | Nc1c(Cl)cc(C(=O)NCCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| 127037820 | 136852 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 398 | 8 | 1 | 5 | 3.0 | COCC(C)(C)CN1C[C@H]2[C@H](CNC(=O)c3nc(C(C)C)n4ccccc34)[C@H]2C1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741918 | 136852 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 398 | 8 | 1 | 5 | 3.0 | COCC(C)(C)CN1C[C@H]2[C@H](CNC(=O)c3nc(C(C)C)n4ccccc34)[C@H]2C1 | 10.1016/j.ejmech.2015.08.051 | ||
| 235 | 2564 | 42 | None | -5 | 3 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/S0960-894X(01)80413-3 | ||
| 5311299 | 2564 | 42 | None | -5 | 3 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL286136 | 2564 | 42 | None | -5 | 3 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/S0960-894X(01)80413-3 | ||
| 132337 | 3543 | 15 | None | 1 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1016/S0960-894X(01)80413-3 | ||
| 238 | 3543 | 15 | None | 1 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL34291 | 3543 | 15 | None | 1 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1016/S0960-894X(01)80413-3 | ||
| 49783211 | 17640 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 488 | 7 | 1 | 6 | 3.8 | CCCCN1CCC(COC(=O)c2cc(I)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258339 | 17640 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 488 | 7 | 1 | 6 | 3.8 | CCCCN1CCC(COC(=O)c2cc(I)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| 5311047 | 204763 | 33 | None | 1 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL74656 | 204763 | 33 | None | 1 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC | 10.1016/j.bmcl.2012.05.034 | ||
| 44248312 91900490 | 195130 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 531 | 12 | 2 | 6 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCS(=O)(=O)O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL550122 | 195130 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 531 | 12 | 2 | 6 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCS(=O)(=O)O)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248066 | 195186 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 473 | 7 | 2 | 7 | 0.7 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN2CCN(S(C)(=O)=O)CC2)CC1 | 10.1021/jm900881j | ||
| CHEMBL550530 | 195186 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 473 | 7 | 2 | 7 | 0.7 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN2CCN(S(C)(=O)=O)CC2)CC1 | 10.1021/jm900881j | ||
| 70691118 | 77501 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 469 | 7 | 3 | 6 | 1.7 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN(C)C(N)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087327 | 77501 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 469 | 7 | 3 | 6 | 1.7 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN(C)C(N)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| 70686943 | 77505 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 497 | 7 | 2 | 6 | 2.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN(C)C(=O)N(C)C)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087331 | 77505 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 497 | 7 | 2 | 6 | 2.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN(C)C(=O)N(C)C)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| 1782 | 2518 | 84 | None | -158 | 13 | Rat | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(96)00002-9 | ||
| 241 | 2518 | 84 | None | -158 | 13 | Rat | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(96)00002-9 | ||
| 4168 | 2518 | 84 | None | -158 | 13 | Rat | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL86 | 2518 | 84 | None | -158 | 13 | Rat | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(96)00002-9 | ||
| DB01233 | 2518 | 84 | None | -158 | 13 | Rat | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(96)00002-9 | ||
| 11493794 | 73030 | 0 | None | 26 | 2 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 337 | 5 | 2 | 4 | 2.5 | CCOc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CCN2CCC[C@@H]12 | 10.1021/jm0509501 | ||
| CHEMBL201019 | 73030 | 0 | None | 26 | 2 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 337 | 5 | 2 | 4 | 2.5 | CCOc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CCN2CCC[C@@H]12 | 10.1021/jm0509501 | ||
| 132164 | 206648 | 12 | None | - | 1 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 321 | 2 | 2 | 4 | 1.7 | Nc1c(Cl)cc(C(=O)N[C@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL89259 | 206648 | 12 | None | - | 1 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 321 | 2 | 2 | 4 | 1.7 | Nc1c(Cl)cc(C(=O)N[C@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| 127039508 | 136829 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 402 | 5 | 1 | 5 | 3.2 | CC(C)c1nc(C(=O)NC2CCN(CC3(F)CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741703 | 136829 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 402 | 5 | 1 | 5 | 3.2 | CC(C)c1nc(C(=O)NC2CCN(CC3(F)CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 10493462 | 202487 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 286 | 3 | 2 | 4 | 2.1 | CC(C)n1nc(C(=O)NC2CCNCC2)c2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL61130 | 202487 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 286 | 3 | 2 | 4 | 2.1 | CC(C)n1nc(C(=O)NC2CCNCC2)c2ccccc21 | 10.1021/jm900881j | ||
| 19081864 | 104954 | 0 | None | - | 1 | Rat | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 352 | 9 | 1 | 4 | 4.6 | CCCOc1cc(N)c(Cl)cc1C(=O)CCCCN1CCCCC1 | 10.1016/S0960-894X(01)80414-5 | ||
| CHEMBL311325 | 104954 | 0 | None | - | 1 | Rat | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 352 | 9 | 1 | 4 | 4.6 | CCCOc1cc(N)c(Cl)cc1C(=O)CCCCN1CCCCC1 | 10.1016/S0960-894X(01)80414-5 | ||
| 183782 | 3398 | 20 | None | 3 | 3 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.ejmech.2015.08.051 | ||
| 237 | 3398 | 20 | None | 3 | 3 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL85251 | 3398 | 20 | None | 3 | 3 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.ejmech.2015.08.051 | ||
| 44213662 | 206597 | 0 | None | - | 1 | Rat | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 324 | 4 | 1 | 5 | 2.5 | Nc1c(Cl)cc(C(=O)OCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL88973 | 206597 | 0 | None | - | 1 | Rat | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 324 | 4 | 1 | 5 | 2.5 | Nc1c(Cl)cc(C(=O)OCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| 71451950 | 82675 | 8 | None | -1 | 2 | Rat | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179582 | 82675 | 8 | None | -1 | 2 | Rat | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 235 | 2564 | 42 | None | -5 | 3 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/j.ejmech.2015.08.051 | ||
| 5311299 | 2564 | 42 | None | -5 | 3 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL286136 | 2564 | 42 | None | -5 | 3 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/j.ejmech.2015.08.051 | ||
| 133076 | 3399 | 6 | None | -1 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 417 | 9 | 2 | 6 | 2.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CCNS(=O)(=O)C)Cl | 10.1016/S0960-894X(01)80413-3 | ||
| 3230 | 3399 | 6 | None | -1 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 417 | 9 | 2 | 6 | 2.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CCNS(=O)(=O)C)Cl | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL83899 | 3399 | 6 | None | -1 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 417 | 9 | 2 | 6 | 2.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CCNS(=O)(=O)C)Cl | 10.1016/S0960-894X(01)80413-3 | ||
| 70696825 | 76412 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 479 | 10 | 1 | 5 | 5.4 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCN2CCCCC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059578 | 76412 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 479 | 10 | 1 | 5 | 5.4 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCN2CCCCC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 11677434 | 76415 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 483 | 9 | 2 | 7 | 2.8 | COC[C@@H]1CCCN1CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059581 | 76415 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 483 | 9 | 2 | 7 | 2.8 | COC[C@@H]1CCCN1CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | ||
| 11225102 | 76424 | 3 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 466 | 6 | 1 | 6 | 2.5 | CC(=O)N1CCN(CCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2nn(C(C)C)c4ccccc24)C3)CC1 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059590 | 76424 | 3 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 466 | 6 | 1 | 6 | 2.5 | CC(=O)N1CCN(CCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2nn(C(C)C)c4ccccc24)C3)CC1 | 10.1016/j.bmcl.2012.05.034 | ||
| 44248191 | 194899 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 537 | 8 | 1 | 7 | 3.5 | CCOC(=O)N1CCN(CCCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2cc4ccccc4n(C(C)C)c2=O)C3)CC1 | 10.1021/jm900881j | ||
| CHEMBL540980 | 194899 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 537 | 8 | 1 | 7 | 3.5 | CCOC(=O)N1CCN(CCCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2cc4ccccc4n(C(C)C)c2=O)C3)CC1 | 10.1021/jm900881j | ||
| 44248195 | 195082 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 466 | 7 | 1 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCOCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL549650 | 195082 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 466 | 7 | 1 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCOCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248679 | 195599 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 599 | 12 | 1 | 7 | 3.8 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL555693 | 195599 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 599 | 12 | 1 | 7 | 3.8 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248315 | 195921 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 522 | 11 | 1 | 6 | 4.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCOCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL559322 | 195921 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 522 | 11 | 1 | 6 | 4.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCOCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 135409453 | 3773 | 41 | None | 28 | 35 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2013.05.018 | ||
| 226 | 3773 | 41 | None | 28 | 35 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL76370 | 3773 | 41 | None | 28 | 35 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2013.05.018 | ||
| 135409453 | 3773 | 41 | None | 28 | 35 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.08.051 | ||
| 226 | 3773 | 41 | None | 28 | 35 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL76370 | 3773 | 41 | None | 28 | 35 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.08.051 | ||
| 155543353 | 173301 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 418 | 7 | 3 | 6 | 4.2 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(Cc2ccc(O)c(O)c2)CC1 | 10.1016/j.ejmech.2019.111596 | ||
| CHEMBL4526049 | 173301 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 418 | 7 | 3 | 6 | 4.2 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(Cc2ccc(O)c(O)c2)CC1 | 10.1016/j.ejmech.2019.111596 | ||
| 127037818 | 136694 | 2 | None | -1 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1C[C@H]2[C@H](CNC(=O)c3nc(C(C)C)n4ccccc34)[C@H]2C1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740472 | 136694 | 2 | None | -1 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1C[C@H]2[C@H](CNC(=O)c3nc(C(C)C)n4ccccc34)[C@H]2C1 | 10.1016/j.ejmech.2015.08.051 | ||
| 127037818 | 136694 | 2 | None | -1 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1C[C@H]2[C@H](CNC(=O)c3nc(C(C)C)n4ccccc34)[C@H]2C1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740472 | 136694 | 2 | None | -1 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1C[C@H]2[C@H](CNC(=O)c3nc(C(C)C)n4ccccc34)[C@H]2C1 | 10.1016/j.ejmech.2015.08.051 | ||
| 127037818 | 136694 | 2 | None | 1 | 2 | Rat | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1C[C@H]2[C@H](CNC(=O)c3nc(C(C)C)n4ccccc34)[C@H]2C1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740472 | 136694 | 2 | None | 1 | 2 | Rat | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1C[C@H]2[C@H](CNC(=O)c3nc(C(C)C)n4ccccc34)[C@H]2C1 | 10.1016/j.ejmech.2015.08.051 | ||
| 127039823 | 136707 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 382 | 5 | 1 | 5 | 2.5 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(C4CCOCC4)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740612 | 136707 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 382 | 5 | 1 | 5 | 2.5 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(C4CCOCC4)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 6604914 | 100384 | 3 | None | - | 1 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1016/S0960-894X(00)80441-2 | ||
| CHEMBL28992 | 100384 | 3 | None | - | 1 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1016/S0960-894X(00)80441-2 | ||
| 9819119 | 203701 | 0 | None | - | 1 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 335 | 4 | 2 | 4 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NCC12CC3CN(CC3C1)C2 | 10.1016/S0960-894X(97)00408-3 | ||
| CHEMBL67555 | 203701 | 0 | None | - | 1 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 335 | 4 | 2 | 4 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NCC12CC3CN(CC3C1)C2 | 10.1016/S0960-894X(97)00408-3 | ||
| 127037818 | 136694 | 2 | None | -1 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1C[C@H]2[C@H](CNC(=O)c3nc(C(C)C)n4ccccc34)[C@H]2C1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740472 | 136694 | 2 | None | -1 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1C[C@H]2[C@H](CNC(=O)c3nc(C(C)C)n4ccccc34)[C@H]2C1 | 10.1016/j.ejmech.2015.08.051 | ||
| 127039819 | 136897 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 356 | 5 | 1 | 5 | 2.4 | CC(C)c1nc(C(=O)NCC2CN(C3CCC3)CCO2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3742300 | 136897 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 356 | 5 | 1 | 5 | 2.4 | CC(C)c1nc(C(=O)NCC2CN(C3CCC3)CCO2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 132337 | 3543 | 15 | None | -1 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1016/j.bmcl.2004.04.021 | ||
| 238 | 3543 | 15 | None | -1 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1016/j.bmcl.2004.04.021 | ||
| CHEMBL34291 | 3543 | 15 | None | -1 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1016/j.bmcl.2004.04.021 | ||
| 132337 | 3543 | 15 | None | -1 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1021/jm020099f | ||
| 238 | 3543 | 15 | None | -1 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1021/jm020099f | ||
| CHEMBL34291 | 3543 | 15 | None | -1 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1021/jm020099f | ||
| 127039510 | 136720 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 370 | 5 | 1 | 5 | 2.7 | CC(C)c1nc(C(=O)NC2CCN(CC3CCOC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740732 | 136720 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 370 | 5 | 1 | 5 | 2.7 | CC(C)c1nc(C(=O)NC2CCN(CC3CCOC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 44248797 | 195712 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 353 | 7 | 2 | 4 | 3.3 | CCCCCN1CCC(NC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm900881j | ||
| CHEMBL557053 | 195712 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 353 | 7 | 2 | 4 | 3.3 | CCCCCN1CCC(NC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm900881j | ||
| 44248552 91900486 | 195919 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 554 | 9 | 1 | 6 | 4.8 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN2C(=O)c3ccccc3C2=O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL559317 | 195919 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 554 | 9 | 1 | 6 | 4.8 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN2C(=O)c3ccccc3C2=O)cc2ccccc21 | 10.1021/jm900881j | ||
| 10574402 91900484 | 196472 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 425 | 8 | 2 | 5 | 3.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCO)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL563261 | 196472 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 425 | 8 | 2 | 5 | 3.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCO)cc2ccccc21 | 10.1021/jm900881j | ||
| 70695323 | 77510 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@H](O)CN(C)S(C)(=O)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087336 | 77510 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@H](O)CN(C)S(C)(=O)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| 71450247 | 82976 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 368 | 5 | 0 | 3 | 5.5 | CCCN1CCC(COc2nc3c(Cl)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181188 | 82976 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 368 | 5 | 0 | 3 | 5.5 | CCCN1CCC(COc2nc3c(Cl)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| 203435 | 164104 | 3 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 311 | 5 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NCCN1CCCCC1 | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL420969 | 164104 | 3 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 311 | 5 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NCCN1CCCCC1 | 10.1016/S0960-894X(01)80413-3 | ||
| 71712612 | 91378 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 490 | 7 | 3 | 7 | 0.2 | CS(=O)(=O)N1CCN(CC(O)CN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2cccc4[nH]cnc24)C3)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402888 | 91378 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 490 | 7 | 3 | 7 | 0.2 | CS(=O)(=O)N1CCN(CC(O)CN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2cccc4[nH]cnc24)C3)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 44249317 91900480 | 195341 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 299 | 3 | 3 | 3 | 2.2 | COc1ccc2[nH]cc(C(=O)N[C@@H]3C[C@@H]4CC[C@H](C3)N4)c2c1 | 10.1021/jm900881j | ||
| CHEMBL551743 | 195341 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 299 | 3 | 3 | 3 | 2.2 | COc1ccc2[nH]cc(C(=O)N[C@@H]3C[C@@H]4CC[C@H](C3)N4)c2c1 | 10.1021/jm900881j | ||
| 243 | 3202 | 91 | None | -1 | 5 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.ejmech.2015.08.051 | ||
| 3052762 | 3202 | 91 | None | -1 | 5 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.ejmech.2015.08.051 | ||
| 3502 | 3202 | 91 | None | -1 | 5 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL117287 | 3202 | 91 | None | -1 | 5 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.ejmech.2015.08.051 | ||
| DB06480 | 3202 | 91 | None | -1 | 5 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.ejmech.2015.08.051 | ||
| 44288600 | 101117 | 0 | None | - | 1 | Rat | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 335 | 3 | 2 | 4 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CC1CN(C3)C2 | 10.1016/S0960-894X(00)80441-2 | ||
| CHEMBL295155 | 101117 | 0 | None | - | 1 | Rat | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 335 | 3 | 2 | 4 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CC1CN(C3)C2 | 10.1016/S0960-894X(00)80441-2 | ||
| 3019427 | 60382 | 33 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 313 | 4 | 3 | 5 | 1.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCNCC1OC | 10.1016/j.bmcl.2009.08.016 | ||
| CHEMBL1748 | 60382 | 33 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 313 | 4 | 3 | 5 | 1.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCNCC1OC | 10.1016/j.bmcl.2009.08.016 | ||
| 44248193 | 194809 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 593 | 12 | 1 | 7 | 5.0 | CCOC(=O)N1CCN(CCCCCCCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2cc4ccccc4n(C(C)C)c2=O)C3)CC1 | 10.1021/jm900881j | ||
| CHEMBL538956 | 194809 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 593 | 12 | 1 | 7 | 5.0 | CCOC(=O)N1CCN(CCCCCCCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2cc4ccccc4n(C(C)C)c2=O)C3)CC1 | 10.1021/jm900881j | ||
| 44248434 91900496 | 195639 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 613 | 13 | 1 | 7 | 4.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL556326 | 195639 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 613 | 13 | 1 | 7 | 4.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44247943 | 195948 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 540 | 12 | 2 | 6 | 4.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN2C(=O)c3ccccc3C2=O)CC1 | 10.1021/jm900881j | ||
| CHEMBL559548 | 195948 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 540 | 12 | 2 | 6 | 4.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN2C(=O)c3ccccc3C2=O)CC1 | 10.1021/jm900881j | ||
| 44249183 | 196380 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 478 | 12 | 2 | 5 | 5.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN2CCCCC2)CC1 | 10.1021/jm900881j | ||
| CHEMBL562636 | 196380 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 478 | 12 | 2 | 5 | 5.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN2CCCCC2)CC1 | 10.1021/jm900881j | ||
| 71714543 | 91383 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 534 | 8 | 3 | 7 | 1.2 | CC(C)(C)c1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402893 | 91383 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 534 | 8 | 3 | 7 | 1.2 | CC(C)(C)c1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| 71712329 | 91389 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 454 | 7 | 2 | 5 | 2.3 | CC(=O)N1CCN(CCN2CCC(CNC(=O)c3cccc4[nH]c(C(C)C)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402899 | 91389 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 454 | 7 | 2 | 5 | 2.3 | CC(=O)N1CCN(CCN2CCC(CNC(=O)c3cccc4[nH]c(C(C)C)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 127041783 | 136588 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 328 | 4 | 1 | 4 | 3.1 | CC(C)c1nc(C(=O)NC2CCN(C(C)C)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3739521 | 136588 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 328 | 4 | 1 | 4 | 3.1 | CC(C)c1nc(C(=O)NC2CCN(C(C)C)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 127039509 | 136741 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 332 | 5 | 1 | 4 | 2.6 | CC(C)c1nc(C(=O)NC2CCN(CCF)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740908 | 136741 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 332 | 5 | 1 | 4 | 2.6 | CC(C)c1nc(C(=O)NC2CCN(CCF)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 183782 | 3398 | 20 | None | 3 | 3 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/S0960-894X(01)80413-3 | ||
| 237 | 3398 | 20 | None | 3 | 3 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL85251 | 3398 | 20 | None | 3 | 3 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/S0960-894X(01)80413-3 | ||
| 11168006 | 76423 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 502 | 7 | 1 | 7 | 1.9 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059589 | 76423 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 502 | 7 | 1 | 7 | 1.9 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 44248080 91900498 | 195876 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 493 | 8 | 2 | 6 | 2.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCC[C@@H]2C(N)=O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL558855 | 195876 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 493 | 8 | 2 | 6 | 2.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCC[C@@H]2C(N)=O)cc2ccccc21 | 10.1021/jm900881j | ||
| 127039824 | 136601 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 396 | 6 | 1 | 5 | 2.8 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(CC4CCOCC4)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3739647 | 136601 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 396 | 6 | 1 | 5 | 2.8 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(CC4CCOCC4)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 10315431 | 98950 | 0 | None | - | 1 | Rat | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 343 | 1 | 1 | 4 | 2.8 | CN1CCC(N2C(=O)c3cccc4c(N)c(Cl)cc(c34)C2=O)CC1 | 10.1016/S0960-894X(00)80352-2 | ||
| CHEMBL27966 | 98950 | 0 | None | - | 1 | Rat | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 343 | 1 | 1 | 4 | 2.8 | CN1CCC(N2C(=O)c3cccc4c(N)c(Cl)cc(c34)C2=O)CC1 | 10.1016/S0960-894X(00)80352-2 | ||
| 44249055 91900481 | 195419 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 367 | 4 | 1 | 4 | 3.3 | CCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1021/jm900881j | ||
| CHEMBL552218 | 195419 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 367 | 4 | 1 | 4 | 3.3 | CCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1021/jm900881j | ||
| 10643698 | 195452 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 383 | 5 | 2 | 5 | 2.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCO)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL552420 | 195452 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 383 | 5 | 2 | 5 | 2.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCO)cc2ccccc21 | 10.1021/jm900881j | ||
| 70682705 | 77503 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 483 | 7 | 3 | 6 | 1.9 | CNC(=O)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087329 | 77503 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 483 | 7 | 3 | 6 | 1.9 | CNC(=O)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| 127041781 | 136649 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 388 | 8 | 2 | 6 | 2.1 | COCCCN1CCC(O)(CNC(=O)c2nc(C(C)C)n3ccccc23)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740030 | 136649 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 388 | 8 | 2 | 6 | 2.1 | COCCCN1CCC(O)(CNC(=O)c2nc(C(C)C)n3ccccc23)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| 10828801 | 104169 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 310 | 6 | 1 | 4 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)CCCN1CCCCC1 | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL309655 | 104169 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 310 | 6 | 1 | 4 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)CCCN1CCCCC1 | 10.1016/S0960-894X(01)80413-3 | ||
| 44248794 | 195512 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 302 | 2 | 2 | 5 | 1.7 | CC(C)n1c(=O)n(C(=O)NC2CCNCC2)c2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL553658 | 195512 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 302 | 2 | 2 | 5 | 1.7 | CC(C)n1c(=O)n(C(=O)NC2CCNCC2)c2ccccc21 | 10.1021/jm900881j | ||
| 15095973 | 136268 | 0 | None | 12 | 2 | Rat | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NC[C@H]1CCN2CCC[C@H]12 | 10.1021/jm0509501 | ||
| CHEMBL37333 | 136268 | 0 | None | 12 | 2 | Rat | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NC[C@H]1CCN2CCC[C@H]12 | 10.1021/jm0509501 | ||
| 22400452 | 102384 | 0 | None | - | 1 | Rat | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 363 | 4 | 2 | 4 | 2.1 | COc1cc(NC(C)=O)c(Cl)cc1C(=O)NC1C2CC3CC1CN3C2 | 10.1016/S0960-894X(97)00408-3 | ||
| CHEMBL303877 | 102384 | 0 | None | - | 1 | Rat | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 363 | 4 | 2 | 4 | 2.1 | COc1cc(NC(C)=O)c(Cl)cc1C(=O)NC1C2CC3CC1CN3C2 | 10.1016/S0960-894X(97)00408-3 | ||
| 127037821 | 136796 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 370 | 6 | 2 | 5 | 2.1 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(CC(C)(C)O)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741377 | 136796 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 370 | 6 | 2 | 5 | 2.1 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(CC(C)(C)O)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 44213663 | 206581 | 0 | None | - | 1 | Rat | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | Nc1c(Cl)cc(C(=O)NCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL88867 | 206581 | 0 | None | - | 1 | Rat | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | Nc1c(Cl)cc(C(=O)NCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| 11596009 | 73374 | 0 | None | - | 1 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 342 | 3 | 1 | 5 | 2.4 | CC(C)n1c(=O)n(C(=O)NC[C@@H]2CCN3CCC[C@@H]23)c2ccccc21 | 10.1021/jm0509501 | ||
| CHEMBL201414 | 73374 | 0 | None | - | 1 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 342 | 3 | 1 | 5 | 2.4 | CC(C)n1c(=O)n(C(=O)NC[C@@H]2CCN3CCC[C@@H]23)c2ccccc21 | 10.1021/jm0509501 | ||
| 9861932 | 203576 | 0 | None | - | 1 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 321 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CC1CN3C2 | 10.1016/S0960-894X(97)00408-3 | ||
| CHEMBL66768 | 203576 | 0 | None | - | 1 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 321 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CC1CN3C2 | 10.1016/S0960-894X(97)00408-3 | ||
| 44323245 | 107024 | 0 | None | - | 1 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 322 | 2 | 1 | 5 | 2.1 | Nc1c(Cl)cc(C(=O)O[C@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL315443 | 107024 | 0 | None | - | 1 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 322 | 2 | 1 | 5 | 2.1 | Nc1c(Cl)cc(C(=O)O[C@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| 73352662 | 93240 | 0 | None | - | 1 | Rat | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 321 | 3 | 2 | 4 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1C2CC3CN(C2)CC31 | 10.1016/S0960-894X(00)80441-2 | ||
| CHEMBL2448137 | 93240 | 0 | None | - | 1 | Rat | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 321 | 3 | 2 | 4 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1C2CC3CN(C2)CC31 | 10.1016/S0960-894X(00)80441-2 | ||
| 127042089 | 136624 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 384 | 5 | 2 | 5 | 3.0 | CC(C)c1nc(C(=O)NC2CC3CCC(C2)N3CC(C)(C)O)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3739826 | 136624 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 384 | 5 | 2 | 5 | 3.0 | CC(C)c1nc(C(=O)NC2CC3CCC(C2)N3CC(C)(C)O)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 19081862 | 205394 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 310 | 5 | 1 | 4 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(C)CC1 | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL80015 | 205394 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 310 | 5 | 1 | 4 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(C)CC1 | 10.1016/S0960-894X(01)80413-3 | ||
| 9799010 | 205881 | 0 | None | 1 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 324 | 7 | 1 | 4 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)CCCCN1CCCCC1 | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL83841 | 205881 | 0 | None | 1 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 324 | 7 | 1 | 4 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)CCCCN1CCCCC1 | 10.1016/S0960-894X(01)80413-3 | ||
| 10757502 91929739 | 195125 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 312 | 3 | 2 | 4 | 2.6 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL550064 | 195125 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 312 | 3 | 2 | 4 | 2.6 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 10757502 91929739 | 195125 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 312 | 3 | 2 | 4 | 2.6 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)c2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL550064 | 195125 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 312 | 3 | 2 | 4 | 2.6 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)c2ccccc21 | 10.1021/jm900881j | ||
| 44247808 | 195379 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 395 | 10 | 2 | 4 | 4.5 | CCCCCCCCN1CCC(NC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm900881j | ||
| CHEMBL551940 | 195379 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 395 | 10 | 2 | 4 | 4.5 | CCCCCCCCN1CCC(NC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm900881j | ||
| 44248187 91900482 | 195380 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 409 | 7 | 1 | 4 | 4.5 | CCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1021/jm900881j | ||
| CHEMBL551941 | 195380 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 409 | 7 | 1 | 4 | 4.5 | CCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1021/jm900881j | ||
| 44248070 | 195824 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 557 | 13 | 2 | 7 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN2CCN(S(C)(=O)=O)CC2)CC1 | 10.1021/jm900881j | ||
| CHEMBL558261 | 195824 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 557 | 13 | 2 | 7 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN2CCN(S(C)(=O)=O)CC2)CC1 | 10.1021/jm900881j | ||
| 44249056 91900483 | 196337 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 451 | 10 | 1 | 4 | 5.7 | CCCCCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1021/jm900881j | ||
| CHEMBL562400 | 196337 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 451 | 10 | 1 | 4 | 5.7 | CCCCCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1021/jm900881j | ||
| 9799010 | 205881 | 0 | None | -1 | 2 | Rat | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 324 | 7 | 1 | 4 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)CCCCN1CCCCC1 | 10.1016/S0960-894X(01)80414-5 | ||
| CHEMBL83841 | 205881 | 0 | None | -1 | 2 | Rat | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 324 | 7 | 1 | 4 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)CCCCN1CCCCC1 | 10.1016/S0960-894X(01)80414-5 | ||
| 9817713 | 194837 | 61 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 297 | 4 | 3 | 4 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCNCC1 | 10.1021/jm900881j | ||
| CHEMBL539652 | 194837 | 61 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 297 | 4 | 3 | 4 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCNCC1 | 10.1021/jm900881j | ||
| 42499 | 194937 | 23 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 283 | 3 | 3 | 4 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)NC1CCNCC1 | 10.1021/jm900881j | ||
| CHEMBL541969 | 194937 | 23 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 283 | 3 | 3 | 4 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)NC1CCNCC1 | 10.1021/jm900881j | ||
| 44247947 | 195333 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 433 | 9 | 3 | 6 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCS(=O)(=O)O)CC1 | 10.1021/jm900881j | ||
| CHEMBL551678 | 195333 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 433 | 9 | 3 | 6 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCS(=O)(=O)O)CC1 | 10.1021/jm900881j | ||
| 44582815 | 173228 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 621 | 11 | 3 | 9 | 3.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCN2C(=O)c3cccc4c(N)ccc(c34)C2=O)CC1 | 10.1021/jm801327q | ||
| CHEMBL452353 | 173228 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 621 | 11 | 3 | 9 | 3.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCN2C(=O)c3cccc4c(N)ccc(c34)C2=O)CC1 | 10.1021/jm801327q | ||
| 22708808 | 207063 | 0 | None | - | 1 | Rat | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 365 | 6 | 2 | 4 | 3.1 | CCCCN1CCC(CNC(=O)c2cc(Cl)c(N)c3c2OCC3)CC1 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL91771 | 207063 | 0 | None | - | 1 | Rat | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 365 | 6 | 2 | 4 | 3.1 | CCCCN1CCC(CNC(=O)c2cc(Cl)c(N)c3c2OCC3)CC1 | 10.1016/0960-894X(96)00002-9 | ||
| 155525723 | 171085 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 515 | 11 | 3 | 7 | 4.2 | COc1cc(/C=C/C(=O)NCCN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)ccc1O | 10.1016/j.ejmech.2019.111596 | ||
| CHEMBL4457426 | 171085 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 515 | 11 | 3 | 7 | 4.2 | COc1cc(/C=C/C(=O)NCCN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)ccc1O | 10.1016/j.ejmech.2019.111596 | ||
| 127041479 | 136844 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 372 | 8 | 1 | 5 | 2.9 | COCCCN1CCC(CNC(=O)c2nc(C(C)C)n3ccccc23)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741821 | 136844 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 372 | 8 | 1 | 5 | 2.9 | COCCCN1CCC(CNC(=O)c2nc(C(C)C)n3ccccc23)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| 127038726 | 136597 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 358 | 5 | 2 | 5 | 2.4 | CC(C)c1nc(C(=O)NC2CCN(CC(C)(C)O)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3739611 | 136597 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 358 | 5 | 2 | 5 | 2.4 | CC(C)c1nc(C(=O)NC2CCN(CC(C)(C)O)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 127042084 | 136839 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 358 | 7 | 1 | 5 | 2.7 | COCCCN1CCC(NC(=O)c2nc(C(C)C)n3ccccc23)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741776 | 136839 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 358 | 7 | 1 | 5 | 2.7 | COCCCN1CCC(NC(=O)c2nc(C(C)C)n3ccccc23)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| 44343153 | 110347 | 0 | None | 1 | 2 | Rat | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 356 | 2 | 1 | 5 | 3.0 | CC(C)n1c(=O)n(C(=O)NC2CC3CCCC(C2)N3C)c2ccccc21 | 10.1021/jm020099f | ||
| CHEMBL324057 | 110347 | 0 | None | 1 | 2 | Rat | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 356 | 2 | 1 | 5 | 3.0 | CC(C)n1c(=O)n(C(=O)NC2CC3CCCC(C2)N3C)c2ccccc21 | 10.1021/jm020099f | ||
| 22400445 | 204094 | 0 | None | - | 1 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 335 | 4 | 2 | 4 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NCC1C2CC3CC1CN3C2 | 10.1016/S0960-894X(97)00408-3 | ||
| CHEMBL70205 | 204094 | 0 | None | - | 1 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 335 | 4 | 2 | 4 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NCC1C2CC3CC1CN3C2 | 10.1016/S0960-894X(97)00408-3 | ||
| 10065690 | 107427 | 0 | None | - | 1 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 337 | 4 | 2 | 4 | 2.5 | COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CCN2CCC[C@@]12C | 10.1016/j.bmcl.2004.04.021 | ||
| CHEMBL318154 | 107427 | 0 | None | - | 1 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 337 | 4 | 2 | 4 | 2.5 | COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CCN2CCC[C@@]12C | 10.1016/j.bmcl.2004.04.021 | ||
| 127042087 | 136808 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 386 | 5 | 1 | 6 | 2.1 | CC(C)c1nc(C(=O)NCC2CN(C3CCOCC3)CCO2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741508 | 136808 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 386 | 5 | 1 | 6 | 2.1 | CC(C)c1nc(C(=O)NCC2CN(C3CCOCC3)CCO2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 127038354 | 136635 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 386 | 7 | 1 | 5 | 3.3 | COCC(C)(C)CN1CCC(NC(=O)c2nc(C(C)C)n3ccccc23)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3739933 | 136635 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 386 | 7 | 1 | 5 | 3.3 | COCC(C)(C)CN1CCC(NC(=O)c2nc(C(C)C)n3ccccc23)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| 127041786 | 136581 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 340 | 5 | 1 | 4 | 3.1 | CC(C)c1nc(C(=O)NC2CCN(CC3CC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3739470 | 136581 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 340 | 5 | 1 | 4 | 3.1 | CC(C)c1nc(C(=O)NC2CCN(CC3CC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 127042085 | 136787 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 370 | 4 | 1 | 5 | 2.8 | CC(C)c1nc(C(=O)NC2CCN(C3CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741322 | 136787 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 370 | 4 | 1 | 5 | 2.8 | CC(C)c1nc(C(=O)NC2CCN(C3CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 70688534 | 76413 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 441 | 8 | 2 | 6 | 3.0 | CC(C)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059579 | 76413 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 441 | 8 | 2 | 6 | 3.0 | CC(C)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | ||
| 70696826 | 76414 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 467 | 11 | 1 | 5 | 5.2 | CC(C)N(C)CCCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059580 | 76414 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 467 | 11 | 1 | 5 | 5.2 | CC(C)N(C)CCCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | ||
| 44247941 | 195788 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 498 | 9 | 2 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN2C(=O)c3ccccc3C2=O)CC1 | 10.1021/jm900881j | ||
| CHEMBL557867 | 195788 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 498 | 9 | 2 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN2C(=O)c3ccccc3C2=O)CC1 | 10.1021/jm900881j | ||
| 44248925 | 196420 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 436 | 9 | 2 | 5 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN2CCCCC2)CC1 | 10.1021/jm900881j | ||
| CHEMBL562902 | 196420 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 436 | 9 | 2 | 5 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN2CCCCC2)CC1 | 10.1021/jm900881j | ||
| 11842633 | 3981 | 21 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 10.1016/j.bmcl.2012.08.051 | ||
| 8425 | 3981 | 21 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087337 | 3981 | 21 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 10.1016/j.bmcl.2012.08.051 | ||
| 70695321 | 77500 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 455 | 7 | 4 | 6 | 1.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CNC(N)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087326 | 77500 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 455 | 7 | 4 | 6 | 1.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CNC(N)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| 243 | 3202 | 91 | None | 1 | 5 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.ejmech.2015.08.051 | ||
| 3052762 | 3202 | 91 | None | 1 | 5 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.ejmech.2015.08.051 | ||
| 3502 | 3202 | 91 | None | 1 | 5 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL117287 | 3202 | 91 | None | 1 | 5 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.ejmech.2015.08.051 | ||
| DB06480 | 3202 | 91 | None | 1 | 5 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.ejmech.2015.08.051 | ||
| 127042670 | 136812 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 384 | 7 | 2 | 5 | 2.4 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(CC(C)(C)CO)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741548 | 136812 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 384 | 7 | 2 | 5 | 2.4 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(CC(C)(C)CO)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 49783419 | 17749 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 366 | 6 | 1 | 6 | 2.8 | CCCCN1CCC(COC(=O)c2cc(F)c(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258671 | 17749 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 366 | 6 | 1 | 6 | 2.8 | CCCCN1CCC(COC(=O)c2cc(F)c(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| 127041785 | 136690 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 314 | 4 | 1 | 4 | 2.7 | CCN1CCC(NC(=O)c2nc(C(C)C)n3ccccc23)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740400 | 136690 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 314 | 4 | 1 | 4 | 2.7 | CCN1CCC(NC(=O)c2nc(C(C)C)n3ccccc23)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| 44248311 91900487 | 195630 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 596 | 12 | 1 | 6 | 5.9 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN2C(=O)c3ccccc3C2=O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL556279 | 195630 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 596 | 12 | 1 | 6 | 5.9 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN2C(=O)c3ccccc3C2=O)cc2ccccc21 | 10.1021/jm900881j | ||
| 127039505 | 136683 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 353 | 4 | 0 | 6 | 4.1 | CC(C)c1nc(-c2nnc(C3CCN(C(C)C)CC3)o2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740313 | 136683 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 353 | 4 | 0 | 6 | 4.1 | CC(C)c1nc(-c2nnc(C3CCN(C(C)C)CC3)o2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 9819593 | 98804 | 3 | None | - | 1 | Rat | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2 | 10.1016/S0960-894X(00)80352-2 | ||
| CHEMBL27846 | 98804 | 3 | None | - | 1 | Rat | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2 | 10.1016/S0960-894X(00)80352-2 | ||
| 44249179 | 194823 | 1 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 312 | 5 | 3 | 5 | 0.6 | COc1cc(N)c(Cl)cc1C(=O)NCCN1CCNCC1 | 10.1021/jm900881j | ||
| CHEMBL539212 | 194823 | 1 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 312 | 5 | 3 | 5 | 0.6 | COc1cc(N)c(Cl)cc1C(=O)NCCN1CCNCC1 | 10.1021/jm900881j | ||
| 9906777 | 93244 | 0 | None | - | 1 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 321 | 3 | 2 | 4 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1C2CC3CN(C2)CC31 | 10.1021/jm0509501 | ||
| CHEMBL2448165 | 93244 | 0 | None | - | 1 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 321 | 3 | 2 | 4 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1C2CC3CN(C2)CC31 | 10.1021/jm0509501 | ||
| 9885123 | 108215 | 1 | None | - | 1 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 321 | 3 | 2 | 4 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CN(C2)CC31 | 10.1016/S0960-894X(97)00408-3 | ||
| CHEMBL319673 | 108215 | 1 | None | - | 1 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 321 | 3 | 2 | 4 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CN(C2)CC31 | 10.1016/S0960-894X(97)00408-3 | ||
| CHEMBL558226 | 108215 | 1 | None | - | 1 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 321 | 3 | 2 | 4 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CN(C2)CC31 | 10.1016/S0960-894X(97)00408-3 | ||
| 235 | 2564 | 42 | None | -5 | 3 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm801327q | ||
| 5311299 | 2564 | 42 | None | -5 | 3 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm801327q | ||
| CHEMBL286136 | 2564 | 42 | None | -5 | 3 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm801327q | ||
| 9906777 | 93244 | 0 | None | - | 1 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 321 | 3 | 2 | 4 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1C2CC3CN(C2)CC31 | 10.1016/S0960-894X(00)80441-2 | ||
| CHEMBL2448165 | 93244 | 0 | None | - | 1 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 321 | 3 | 2 | 4 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1C2CC3CN(C2)CC31 | 10.1016/S0960-894X(00)80441-2 | ||
| 127039503 | 136578 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 379 | 5 | 0 | 6 | 4.5 | CC(C)c1nc(-c2nnc(C3CCN(CC4CCC4)CC3)o2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3739455 | 136578 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 379 | 5 | 0 | 6 | 4.5 | CC(C)c1nc(-c2nnc(C3CCN(CC4CCC4)CC3)o2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 127039169 | 136760 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 412 | 6 | 1 | 5 | 3.7 | CC(C)c1nc(C(=O)NCC2(C)CCN(CC3CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741062 | 136760 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 412 | 6 | 1 | 5 | 3.7 | CC(C)c1nc(C(=O)NCC2(C)CCN(CC3CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 44288600 | 101117 | 0 | None | - | 1 | Rat | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 335 | 3 | 2 | 4 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CC1CN(C3)C2 | 10.1016/S0960-894X(00)80441-2 | ||
| CHEMBL295155 | 101117 | 0 | None | - | 1 | Rat | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 335 | 3 | 2 | 4 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CC1CN(C3)C2 | 10.1016/S0960-894X(00)80441-2 | ||
| 240 | 944 | 43 | None | -10 | 22 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0509501 | ||
| 2769 | 944 | 43 | None | -10 | 22 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0509501 | ||
| 44279790 | 944 | 43 | None | -10 | 22 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0509501 | ||
| 660 | 944 | 43 | None | -10 | 22 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0509501 | ||
| CHEMBL1729 | 944 | 43 | None | -10 | 22 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0509501 | ||
| CHEMBL560739 | 944 | 43 | None | -10 | 22 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0509501 | ||
| DB00604 | 944 | 43 | None | -10 | 22 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0509501 | ||
| 240 | 944 | 43 | None | -10 | 22 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/S0960-894X(00)80441-2 | ||
| 2769 | 944 | 43 | None | -10 | 22 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/S0960-894X(00)80441-2 | ||
| 44279790 | 944 | 43 | None | -10 | 22 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/S0960-894X(00)80441-2 | ||
| 660 | 944 | 43 | None | -10 | 22 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/S0960-894X(00)80441-2 | ||
| CHEMBL1729 | 944 | 43 | None | -10 | 22 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/S0960-894X(00)80441-2 | ||
| CHEMBL560739 | 944 | 43 | None | -10 | 22 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/S0960-894X(00)80441-2 | ||
| DB00604 | 944 | 43 | None | -10 | 22 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/S0960-894X(00)80441-2 | ||
| 6604914 | 100384 | 3 | None | - | 1 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL28992 | 100384 | 3 | None | - | 1 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1016/0960-894X(96)00002-9 | ||
| 127041782 | 136579 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 414 | 6 | 2 | 6 | 2.4 | CC(C)c1nc(C(=O)NCC2(O)CCN(CC3CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3739459 | 136579 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 414 | 6 | 2 | 6 | 2.4 | CC(C)c1nc(C(=O)NCC2(O)CCN(CC3CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 54677674 | 112809 | 4 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3291085 | 112809 | 4 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3306918 | 112809 | 4 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1016/j.ejmech.2015.08.051 | ||
| 71460941 | 82681 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 374 | 8 | 0 | 5 | 5.1 | CCCCN1CCC(COc2noc3cccc(OCC(C)(C)C)c23)CC1 | 10.1021/jm300953p | ||
| CHEMBL2179588 | 82681 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 374 | 8 | 0 | 5 | 5.1 | CCCCN1CCC(COc2noc3cccc(OCC(C)(C)C)c23)CC1 | 10.1021/jm300953p | ||
| 5 | 139 | 72 | None | -29 | 26 | Rat | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/S0960-894X(00)80352-2 | ||
| 5202 | 139 | 72 | None | -29 | 26 | Rat | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/S0960-894X(00)80352-2 | ||
| CHEMBL39 | 139 | 72 | None | -29 | 26 | Rat | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/S0960-894X(00)80352-2 | ||
| DB08839 | 139 | 72 | None | -29 | 26 | Rat | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/S0960-894X(00)80352-2 | ||
| 44249189 91900488 | 195402 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 447 | 6 | 2 | 6 | 2.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCS(=O)(=O)O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL552075 | 195402 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 447 | 6 | 2 | 6 | 2.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCS(=O)(=O)O)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248433 91900494 | 196741 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 529 | 7 | 1 | 7 | 1.9 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL565146 | 196741 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 529 | 7 | 1 | 7 | 1.9 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 67276466 | 77498 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 454 | 7 | 3 | 6 | 1.8 | CC(=O)NCC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087324 | 77498 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 454 | 7 | 3 | 6 | 1.8 | CC(=O)NCC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| 6604914 | 100384 | 3 | None | - | 1 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1016/S0960-894X(00)80352-2 | ||
| CHEMBL28992 | 100384 | 3 | None | - | 1 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1016/S0960-894X(00)80352-2 | ||
| 19081962 | 106859 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 380 | 10 | 1 | 4 | 5.2 | CCCCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL314489 | 106859 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 380 | 10 | 1 | 4 | 5.2 | CCCCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1016/S0960-894X(01)80413-3 | ||
| 20030109 | 196351 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 327 | 5 | 3 | 5 | 1.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCO)CC1 | 10.1021/jm900881j | ||
| CHEMBL562477 | 196351 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 327 | 5 | 3 | 5 | 1.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCO)CC1 | 10.1021/jm900881j | ||
| 71461050 | 82977 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 352 | 5 | 0 | 3 | 5.0 | CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181189 | 82977 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 352 | 5 | 0 | 3 | 5.0 | CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| 44374544 | 53153 | 0 | None | - | 1 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCC1C2 | 10.1016/S0960-894X(01)81243-9 | ||
| CHEMBL159825 | 53153 | 0 | None | - | 1 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCC1C2 | 10.1016/S0960-894X(01)81243-9 | ||
| 44247815 | 196475 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 456 | 6 | 2 | 6 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN2C(=O)c3ccccc3C2=O)CC1 | 10.1021/jm900881j | ||
| CHEMBL563276 | 196475 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 456 | 6 | 2 | 6 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN2C(=O)c3ccccc3C2=O)CC1 | 10.1021/jm900881j | ||
| 71712613 | 91379 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 464 | 7 | 3 | 7 | -0.3 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(NC(=O)c3cccc4[nH]cnc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402889 | 91379 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 464 | 7 | 3 | 7 | -0.3 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(NC(=O)c3cccc4[nH]cnc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 44248795 | 197631 | 0 | None | - | 1 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 287 | 4 | 3 | 3 | 1.9 | COc1ccc2[nH]cc(C(=O)NCC3CCNCC3)c2c1 | 10.1021/jm900881j | ||
| CHEMBL570780 | 197631 | 0 | None | - | 1 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 287 | 4 | 3 | 3 | 1.9 | COc1ccc2[nH]cc(C(=O)NCC3CCNCC3)c2c1 | 10.1021/jm900881j | ||
| 127041779 | 136737 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 390 | 8 | 1 | 5 | 3.0 | COCCCN1CCC(F)(CNC(=O)c2nc(C(C)C)n3ccccc23)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740864 | 136737 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 390 | 8 | 1 | 5 | 3.0 | COCCCN1CCC(F)(CNC(=O)c2nc(C(C)C)n3ccccc23)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| 132337 | 3543 | 15 | None | -1 | 2 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1016/j.bmcl.2004.04.021 | ||
| 238 | 3543 | 15 | None | -1 | 2 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1016/j.bmcl.2004.04.021 | ||
| CHEMBL34291 | 3543 | 15 | None | -1 | 2 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1016/j.bmcl.2004.04.021 | ||
| 22400445 | 204094 | 0 | None | - | 1 | Rat | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 335 | 4 | 2 | 4 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NCC1C2CC3CC1CN3C2 | 10.1016/S0960-894X(97)00408-3 | ||
| CHEMBL70205 | 204094 | 0 | None | - | 1 | Rat | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 335 | 4 | 2 | 4 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NCC1C2CC3CC1CN3C2 | 10.1016/S0960-894X(97)00408-3 | ||
| 42618252 | 186680 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 580 | 13 | 3 | 8 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCNS(=O)(=O)c2ccc(C)cc2)CC1 | 10.1021/jm801327q | ||
| CHEMBL488325 | 186680 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 580 | 13 | 3 | 8 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCNS(=O)(=O)c2ccc(C)cc2)CC1 | 10.1021/jm801327q | ||
| 44213661 | 207077 | 0 | None | - | 1 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 338 | 5 | 1 | 5 | 2.9 | Nc1c(Cl)cc(C(=O)OCCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL91842 | 207077 | 0 | None | - | 1 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 338 | 5 | 1 | 5 | 2.9 | Nc1c(Cl)cc(C(=O)OCCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| 44248437 | 194836 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 597 | 12 | 1 | 6 | 6.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCN(c3ccccc3)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL539651 | 194836 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 597 | 12 | 1 | 6 | 6.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCN(c3ccccc3)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44249315 | 195175 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 331 | 4 | 2 | 6 | 0.8 | CC(C)n1c(=O)n(C(=O)NCCN2CCNCC2)c2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL550459 | 195175 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 331 | 4 | 2 | 6 | 0.8 | CC(C)n1c(=O)n(C(=O)NCCN2CCNCC2)c2ccccc21 | 10.1021/jm900881j | ||
| 67276168 | 77508 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 490 | 8 | 3 | 7 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CNS(C)(=O)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087334 | 77508 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 490 | 8 | 3 | 7 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CNS(C)(=O)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| 9861932 | 203576 | 0 | None | - | 1 | Rat | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 321 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CC1CN3C2 | 10.1016/S0960-894X(97)00408-3 | ||
| CHEMBL66768 | 203576 | 0 | None | - | 1 | Rat | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 321 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CC1CN3C2 | 10.1016/S0960-894X(97)00408-3 | ||
| 127039168 | 136880 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 388 | 6 | 3 | 6 | 1.8 | CC(C)c1nc(C(=O)NCC2(O)CCN(CC(C)(C)O)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3742145 | 136880 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 388 | 6 | 3 | 6 | 1.8 | CC(C)c1nc(C(=O)NCC2(O)CCN(CC(C)(C)O)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 127039506 | 136580 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 383 | 7 | 0 | 7 | 3.7 | COCCCN1CCC(c2nnc(-c3nc(C(C)C)n4ccccc34)o2)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3739467 | 136580 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 383 | 7 | 0 | 7 | 3.7 | COCCCN1CCC(c2nnc(-c3nc(C(C)C)n4ccccc34)o2)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| 71461049 | 82975 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 364 | 6 | 0 | 4 | 4.9 | CCCN1CCC(COc2nc3c(OC)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181187 | 82975 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 364 | 6 | 0 | 4 | 4.9 | CCCN1CCC(COc2nc3c(OC)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| 44248310 | 196556 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 512 | 6 | 1 | 6 | 3.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2C(=O)c3ccccc3C2=O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL563799 | 196556 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 512 | 6 | 1 | 6 | 3.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2C(=O)c3ccccc3C2=O)cc2ccccc21 | 10.1021/jm900881j | ||
| 44575 | 197516 | 1 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 311 | 4 | 2 | 4 | 2.1 | CCN1CCC(NC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm900881j | ||
| CHEMBL570074 | 197516 | 1 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 311 | 4 | 2 | 4 | 2.1 | CCN1CCC(NC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm900881j | ||
| 240 | 944 | 43 | None | 1 | 22 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| 2769 | 944 | 43 | None | 1 | 22 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| 44279790 | 944 | 43 | None | 1 | 22 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| 660 | 944 | 43 | None | 1 | 22 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL1729 | 944 | 43 | None | 1 | 22 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL560739 | 944 | 43 | None | 1 | 22 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| DB00604 | 944 | 43 | None | 1 | 22 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| 5311047 | 204763 | 33 | None | 1 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL74656 | 204763 | 33 | None | 1 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC | 10.1016/j.bmcl.2012.08.051 | ||
| 1782 | 2518 | 84 | None | -3 | 13 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80413-3 | ||
| 241 | 2518 | 84 | None | -3 | 13 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80413-3 | ||
| 4168 | 2518 | 84 | None | -3 | 13 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL86 | 2518 | 84 | None | -3 | 13 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80413-3 | ||
| DB01233 | 2518 | 84 | None | -3 | 13 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80413-3 | ||
| 1782 | 2518 | 84 | None | -158 | 13 | Rat | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)81243-9 | ||
| 241 | 2518 | 84 | None | -158 | 13 | Rat | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)81243-9 | ||
| 4168 | 2518 | 84 | None | -158 | 13 | Rat | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)81243-9 | ||
| CHEMBL86 | 2518 | 84 | None | -158 | 13 | Rat | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)81243-9 | ||
| DB01233 | 2518 | 84 | None | -158 | 13 | Rat | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)81243-9 | ||
| 44323244 | 12385 | 0 | None | - | 1 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 378 | 5 | 2 | 3 | 3.0 | CCCC[N+]12CCC(CC1)[C@H](NC(=O)c1cc(Cl)c(N)c3c1OCC3)C2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL1185621 | 12385 | 0 | None | - | 1 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 378 | 5 | 2 | 3 | 3.0 | CCCC[N+]12CCC(CC1)[C@H](NC(=O)c1cc(Cl)c(N)c3c1OCC3)C2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL423504 | 12385 | 0 | None | - | 1 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 378 | 5 | 2 | 3 | 3.0 | CCCC[N+]12CCC(CC1)[C@H](NC(=O)c1cc(Cl)c(N)c3c1OCC3)C2 | 10.1016/0960-894X(96)00002-9 | ||
| 127037819 | 136713 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 453 | 6 | 1 | 6 | 2.8 | COC(=O)N1CCC(CN2C[C@H]3[C@H](CNC(=O)c4nc(C(C)C)n5ccccc45)[C@H]3C2)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740669 | 136713 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 453 | 6 | 1 | 6 | 2.8 | COC(=O)N1CCC(CN2C[C@H]3[C@H](CNC(=O)c4nc(C(C)C)n5ccccc45)[C@H]3C2)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| 49783207 | 17578 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 362 | 7 | 1 | 6 | 3.2 | CCCCN1CCC(COC(=O)c2ccc(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258109 | 17578 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 362 | 7 | 1 | 6 | 3.2 | CCCCN1CCC(COC(=O)c2ccc(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| 127039170 | 136773 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 365 | 4 | 0 | 6 | 4.2 | CC(C)c1nc(-c2nnc(C3CCN(C4CCC4)CC3)o2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741199 | 136773 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 365 | 4 | 0 | 6 | 4.2 | CC(C)c1nc(-c2nnc(C3CCN(C4CCC4)CC3)o2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 127039504 | 136645 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 365 | 5 | 0 | 6 | 4.1 | CC(C)c1nc(-c2nnc(C3CCN(CC4CC4)CC3)o2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740000 | 136645 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 365 | 5 | 0 | 6 | 4.1 | CC(C)c1nc(-c2nnc(C3CCN(CC4CC4)CC3)o2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 127042088 | 136869 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 426 | 5 | 2 | 6 | 2.7 | CC(C)c1nc(C(=O)NC2CC3CCC(C2)N3CC2(O)CCOCC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3742080 | 136869 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 426 | 5 | 2 | 6 | 2.7 | CC(C)c1nc(C(=O)NC2CC3CCC(C2)N3CC2(O)CCOCC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 42618250 | 169461 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 982 | 28 | 6 | 14 | 5.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCNCCCc2ccc(CCCNCCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)cc2)CC1 | 10.1021/jm801327q | ||
| CHEMBL442869 | 169461 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 982 | 28 | 6 | 14 | 5.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCNCCCc2ccc(CCCNCCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)cc2)CC1 | 10.1021/jm801327q | ||
| 44372468 | 11675 | 0 | None | - | 1 | Rat | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 380 | 6 | 2 | 3 | 3.5 | CCCC[N+]12CCCC(C1)C(NC(=O)c1cc(Cl)c(N)cc1OC)CC2 | 10.1016/S0960-894X(01)81243-9 | ||
| CHEMBL1181147 | 11675 | 0 | None | - | 1 | Rat | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 380 | 6 | 2 | 3 | 3.5 | CCCC[N+]12CCCC(C1)C(NC(=O)c1cc(Cl)c(N)cc1OC)CC2 | 10.1016/S0960-894X(01)81243-9 | ||
| CHEMBL156977 | 11675 | 0 | None | - | 1 | Rat | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 380 | 6 | 2 | 3 | 3.5 | CCCC[N+]12CCCC(C1)C(NC(=O)c1cc(Cl)c(N)cc1OC)CC2 | 10.1016/S0960-894X(01)81243-9 | ||
| 127039825 | 136841 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 439 | 5 | 1 | 6 | 2.6 | COC(=O)N1CCC(N2C[C@H]3[C@H](CNC(=O)c4nc(C(C)C)n5ccccc45)[C@H]3C2)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741787 | 136841 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 439 | 5 | 1 | 6 | 2.6 | COC(=O)N1CCC(N2C[C@H]3[C@H](CNC(=O)c4nc(C(C)C)n5ccccc45)[C@H]3C2)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| 439280 | 120019 | 107 | None | -13 | 9 | Rat | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 220 | 3 | 4 | 3 | 0.8 | N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O | 10.1016/S0960-894X(01)81243-9 | ||
| 6971044 | 120019 | 107 | None | -13 | 9 | Rat | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 220 | 3 | 4 | 3 | 0.8 | N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O | 10.1016/S0960-894X(01)81243-9 | ||
| CHEMBL350221 | 120019 | 107 | None | -13 | 9 | Rat | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 220 | 3 | 4 | 3 | 0.8 | N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O | 10.1016/S0960-894X(01)81243-9 | ||
| 127041481 | 136833 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 354 | 5 | 1 | 4 | 3.5 | CC(C)c1nc(C(=O)NCC2CCN(C3CCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741733 | 136833 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 354 | 5 | 1 | 4 | 3.5 | CC(C)c1nc(C(=O)NCC2CCN(C3CCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 44626294 | 198999 | 0 | None | -2 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 517 | 7 | 4 | 7 | 3.5 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(C[C@@H]2CCCC[C@@]2(O)c2cccc(O)c2)C[C@H]1OC | 10.1016/j.bmcl.2009.08.016 | ||
| CHEMBL585567 | 198999 | 0 | None | -2 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 517 | 7 | 4 | 7 | 3.5 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(C[C@@H]2CCCC[C@@]2(O)c2cccc(O)c2)C[C@H]1OC | 10.1016/j.bmcl.2009.08.016 | ||
| 6917985 | 93253 | 9 | None | 64 | 2 | Rat | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN2CCC[C@@H]1C2 | 10.1021/jm0509501 | ||
| CHEMBL2448558 | 93253 | 9 | None | 64 | 2 | Rat | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN2CCC[C@@H]1C2 | 10.1021/jm0509501 | ||
| 44374544 | 53153 | 0 | None | - | 1 | Rat | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCC1C2 | 10.1016/S0960-894X(00)80441-2 | ||
| CHEMBL159825 | 53153 | 0 | None | - | 1 | Rat | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCC1C2 | 10.1016/S0960-894X(00)80441-2 | ||
| 119376 | 1841 | 48 | None | 1202 | 3 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm300573d | ||
| 247 | 1841 | 48 | None | 1202 | 3 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm300573d | ||
| CHEMBL33884 | 1841 | 48 | None | 1202 | 3 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm300573d | ||
| 235 | 2564 | 42 | None | 5 | 3 | Rat | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/S0960-894X(01)80508-4 | ||
| 5311299 | 2564 | 42 | None | 5 | 3 | Rat | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/S0960-894X(01)80508-4 | ||
| CHEMBL286136 | 2564 | 42 | None | 5 | 3 | Rat | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/S0960-894X(01)80508-4 | ||
| 44628198 | 82723 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 443 | 7 | 1 | 5 | 4.8 | Cn1cc2c(OCC3CCN(CCc4ccc(C(=O)O)cc4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | ||
| CHEMBL2179674 | 82723 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 443 | 7 | 1 | 5 | 4.8 | Cn1cc2c(OCC3CCN(CCc4ccc(C(=O)O)cc4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | ||
| 5 | 139 | 72 | None | -29 | 26 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/S0960-894X(01)80508-4 | ||
| 5202 | 139 | 72 | None | -29 | 26 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/S0960-894X(01)80508-4 | ||
| CHEMBL39 | 139 | 72 | None | -29 | 26 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/S0960-894X(01)80508-4 | ||
| DB08839 | 139 | 72 | None | -29 | 26 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/S0960-894X(01)80508-4 | ||
| 19956256 | 115298 | 0 | None | -1 | 5 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 275 | 4 | 0 | 5 | 2.5 | Cc1csc2c1-n1cccc1/C2=N/OCCN(C)C | 10.1016/s0960-894x(00)00691-0 | ||
| CHEMBL334923 | 115298 | 0 | None | -1 | 5 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 275 | 4 | 0 | 5 | 2.5 | Cc1csc2c1-n1cccc1/C2=N/OCCN(C)C | 10.1016/s0960-894x(00)00691-0 | ||
| 68490431 | 82728 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 448 | 8 | 2 | 5 | 4.0 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc(C(=O)O)cc3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| CHEMBL2179707 | 82728 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 448 | 8 | 2 | 5 | 4.0 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc(C(=O)O)cc3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| 9800656 | 15550 | 0 | None | - | 1 | Human | 9.2 | pKd | = | 9.2 | Functional | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | ||
| CHEMBL121913 | 15550 | 0 | None | - | 1 | Human | 9.2 | pKd | = | 9.2 | Functional | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | ||
| 44407083 | 73910 | 0 | None | - | 0 | Rat | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 284 | 3 | 1 | 3 | 2.8 | O=C(OC[C@@H]1CCN2CCC[C@@H]12)c1c[nH]c2ccccc12 | 10.1021/jm0509501 | ||
| CHEMBL201946 | 73910 | 0 | None | - | 0 | Rat | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 284 | 3 | 1 | 3 | 2.8 | O=C(OC[C@@H]1CCN2CCC[C@@H]12)c1c[nH]c2ccccc12 | 10.1021/jm0509501 | ||
| 11537858 | 134829 | 0 | None | - | 0 | Rat | 7.0 | pKd | = | 7 | Functional | ChEMBL | 327 | 2 | 1 | 3 | 2.5 | CC1(C)C(=O)N(C(=O)NC[C@@H]2CCN3CCC[C@@H]23)c2ccccc21 | 10.1021/jm0509501 | ||
| CHEMBL371883 | 134829 | 0 | None | - | 0 | Rat | 7.0 | pKd | = | 7 | Functional | ChEMBL | 327 | 2 | 1 | 3 | 2.5 | CC1(C)C(=O)N(C(=O)NC[C@@H]2CCN3CCC[C@@H]23)c2ccccc21 | 10.1021/jm0509501 | ||
| 11515258 | 74400 | 0 | None | - | 0 | Rat | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 319 | 3 | 0 | 5 | 2.6 | O=C(OC[C@@H]1CCN2CCC[C@@H]12)c1cc(Cl)cn2ccnc12 | 10.1021/jm0509501 | ||
| CHEMBL202481 | 74400 | 0 | None | - | 0 | Rat | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 319 | 3 | 0 | 5 | 2.6 | O=C(OC[C@@H]1CCN2CCC[C@@H]12)c1cc(Cl)cn2ccnc12 | 10.1021/jm0509501 | ||
| 11529314 | 141340 | 0 | None | - | 0 | Rat | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 284 | 3 | 1 | 4 | 1.5 | O=C(NC[C@@H]1CCN2CCC[C@@H]12)c1cccn2ccnc12 | 10.1021/jm0509501 | ||
| CHEMBL383554 | 141340 | 0 | None | - | 0 | Rat | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 284 | 3 | 1 | 4 | 1.5 | O=C(NC[C@@H]1CCN2CCC[C@@H]12)c1cccn2ccnc12 | 10.1021/jm0509501 | ||
| 11522273 | 141345 | 0 | None | - | 0 | Rat | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 299 | 3 | 0 | 5 | 2.2 | Cn1nc(C(=O)OC[C@@H]2CCN3CCC[C@@H]23)c2ccccc21 | 10.1021/jm0509501 | ||
| CHEMBL383577 | 141345 | 0 | None | - | 0 | Rat | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 299 | 3 | 0 | 5 | 2.2 | Cn1nc(C(=O)OC[C@@H]2CCN3CCC[C@@H]23)c2ccccc21 | 10.1021/jm0509501 | ||
| 11580445 | 73964 | 0 | None | - | 0 | Rat | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 312 | 4 | 1 | 4 | 2.1 | CCc1nc(C(=O)NC[C@@H]2CCN3CCC[C@@H]23)c2ccccn12 | 10.1021/jm0509501 | ||
| CHEMBL202149 | 73964 | 0 | None | - | 0 | Rat | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 312 | 4 | 1 | 4 | 2.1 | CCc1nc(C(=O)NC[C@@H]2CCN3CCC[C@@H]23)c2ccccn12 | 10.1021/jm0509501 | ||
| 11580890 | 73946 | 0 | None | - | 0 | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 302 | 3 | 1 | 3 | 2.9 | O=C(OC[C@@H]1CCN2CCC[C@@H]12)c1c[nH]c2ccc(F)cc12 | 10.1021/jm0509501 | ||
| CHEMBL202122 | 73946 | 0 | None | - | 0 | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 302 | 3 | 1 | 3 | 2.9 | O=C(OC[C@@H]1CCN2CCC[C@@H]12)c1c[nH]c2ccc(F)cc12 | 10.1021/jm0509501 | ||
| 11508052 | 73837 | 0 | None | - | 0 | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 285 | 3 | 1 | 4 | 2.2 | O=C(OC[C@@H]1CCN2CCC[C@@H]12)c1[nH]nc2ccccc12 | 10.1021/jm0509501 | ||
| CHEMBL201878 | 73837 | 0 | None | - | 0 | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 285 | 3 | 1 | 4 | 2.2 | O=C(OC[C@@H]1CCN2CCC[C@@H]12)c1[nH]nc2ccccc12 | 10.1021/jm0509501 | ||
| 133999 | 74315 | 8 | None | - | 0 | Rat | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 318 | 3 | 1 | 4 | 2.2 | O=C(NC[C@@H]1CCN2CCC[C@@H]12)c1cc(Cl)cn2ccnc12 | 10.1021/jm0509501 | ||
| CHEMBL202434 | 74315 | 8 | None | - | 0 | Rat | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 318 | 3 | 1 | 4 | 2.2 | O=C(NC[C@@H]1CCN2CCC[C@@H]12)c1cc(Cl)cn2ccnc12 | 10.1021/jm0509501 | ||
| 11508567 | 165969 | 0 | None | - | 0 | Rat | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 314 | 4 | 1 | 4 | 2.8 | COc1ccc2[nH]cc(C(=O)OC[C@@H]3CCN4CCC[C@@H]34)c2c1 | 10.1021/jm0509501 | ||
| CHEMBL425222 | 165969 | 0 | None | - | 0 | Rat | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 314 | 4 | 1 | 4 | 2.8 | COc1ccc2[nH]cc(C(=O)OC[C@@H]3CCN4CCC[C@@H]34)c2c1 | 10.1021/jm0509501 | ||
| 11500906 | 135357 | 0 | None | - | 0 | Rat | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 332 | 3 | 1 | 4 | 2.5 | Cc1cnc2c(C(=O)NC[C@@H]3CCN4CCC[C@@H]34)cc(Cl)cn12 | 10.1021/jm0509501 | ||
| CHEMBL372776 | 135357 | 0 | None | - | 0 | Rat | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 332 | 3 | 1 | 4 | 2.5 | Cc1cnc2c(C(=O)NC[C@@H]3CCN4CCC[C@@H]34)cc(Cl)cn12 | 10.1021/jm0509501 | ||
| 119376 | 1841 | 48 | None | 1202 | 3 | Human | 10.1 | pKi | = | 10.1 | Functional | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.bmc.2010.10.011 | ||
| 247 | 1841 | 48 | None | 1202 | 3 | Human | 10.1 | pKi | = | 10.1 | Functional | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL33884 | 1841 | 48 | None | 1202 | 3 | Human | 10.1 | pKi | = | 10.1 | Functional | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.bmc.2010.10.011 | ||
| 119376 | 1841 | 48 | None | 1202 | 3 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm070552t | ||
| 247 | 1841 | 48 | None | 1202 | 3 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm070552t | ||
| CHEMBL33884 | 1841 | 48 | None | 1202 | 3 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm070552t | ||
| 53318069 | 56436 | 0 | None | - | 0 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 344 | 7 | 2 | 4 | 2.9 | O=C(O)CCCN1CCC(COC(=O)c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL1632154 | 56436 | 0 | None | - | 0 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 344 | 7 | 2 | 4 | 2.9 | O=C(O)CCCN1CCC(COC(=O)c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| 53318070 | 56437 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 371 | 8 | 2 | 4 | 3.0 | CCOC(=O)CCCN1CCC(CNC(=O)c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL1632155 | 56437 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 371 | 8 | 2 | 4 | 3.0 | CCOC(=O)CCCN1CCC(CNC(=O)c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| 11557207 | 79055 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 1203 | 39 | 7 | 18 | 10.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCNc2nc(NCCCCCCCCCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)nc(NCc3ccccc3)n2)CC1 | 10.1021/jm070552t | ||
| CHEMBL2113160 | 79055 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 1203 | 39 | 7 | 18 | 10.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCNc2nc(NCCCCCCCCCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)nc(NCc3ccccc3)n2)CC1 | 10.1021/jm070552t | ||
| 17755141 | 79125 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 1183 | 28 | 4 | 16 | 9.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCN(CCCc2ccc(CCCN(CCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| CHEMBL2113289 | 79125 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 1183 | 28 | 4 | 16 | 9.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCN(CCCc2ccc(CCCN(CCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| 46905984 | 10414 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 1179 | 30 | 4 | 14 | 8.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCN(CCCc2ccc(CCCN(CCCC(=O)NCC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)C(C)(C)C)cc2)C(=O)C(C)(C)C)CC1 | 10.1021/jm070552t | ||
| CHEMBL1162955 | 10414 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 1179 | 30 | 4 | 14 | 8.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCN(CCCc2ccc(CCCN(CCCC(=O)NCC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)C(C)(C)C)cc2)C(=O)C(C)(C)C)CC1 | 10.1021/jm070552t | ||
| 44427806 | 143913 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 1151 | 28 | 4 | 14 | 8.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCN(CCCc2cccc(CCCN(CCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)C(C)(C)C)c2)C(=O)C(C)(C)C)CC1 | 10.1021/jm070552t | ||
| CHEMBL390202 | 143913 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 1151 | 28 | 4 | 14 | 8.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCN(CCCc2cccc(CCCN(CCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)C(C)(C)C)c2)C(=O)C(C)(C)C)CC1 | 10.1021/jm070552t | ||
| 10666935 | 207950 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 371 | 5 | 1 | 6 | 1.7 | CC(C)N1CCN(CCNC(=O)n2c(=O)n(C3CC3)c3ccccc32)CC1 | 10.1021/jm020099f | ||
| CHEMBL97019 | 207950 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 371 | 5 | 1 | 6 | 1.7 | CC(C)N1CCN(CCNC(=O)n2c(=O)n(C3CC3)c3ccccc32)CC1 | 10.1021/jm020099f | ||
| 17755040 | 79121 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 1175 | 22 | 4 | 16 | 7.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCN(CC#Cc2ccc(C#CCN(CCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| CHEMBL2113285 | 79121 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 1175 | 22 | 4 | 16 | 7.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCN(CC#Cc2ccc(C#CCN(CCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| 17755140 | 79124 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 1155 | 26 | 4 | 16 | 7.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CN(CCCc2ccc(CCCN(CC(=O)NCC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| CHEMBL2113288 | 79124 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 1155 | 26 | 4 | 16 | 7.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CN(CCCc2ccc(CCCN(CC(=O)NCC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| 11622025 | 143746 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 848 | 23 | 4 | 12 | 6.1 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm070552t | ||
| CHEMBL390075 | 143746 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 848 | 23 | 4 | 12 | 6.1 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm070552t | ||
| 17756519 | 79126 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 1211 | 30 | 4 | 16 | 9.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCN(CCCc2cccc(CCCN(CCCC(=O)NCC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)c2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| CHEMBL2113290 | 79126 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 1211 | 30 | 4 | 16 | 9.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCN(CCCc2cccc(CCCN(CCCC(=O)NCC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)c2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| 17756415 | 79123 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 1203 | 24 | 4 | 16 | 8.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCN(CC#Cc2ccc(C#CCN(CCCC(=O)NCC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| CHEMBL2113287 | 79123 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 1203 | 24 | 4 | 16 | 8.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCN(CC#Cc2ccc(C#CCN(CCCC(=O)NCC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| 11724799 | 10532 | 0 | None | - | 0 | Rat | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 339 | 0 | 2 | 5 | 1.5 | Nc1cc2c(cc1Cl)C(=O)NC1CCN(CCOCCO2)CC1 | 10.1021/jm020099f | ||
| CHEMBL116913 | 10532 | 0 | None | - | 0 | Rat | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 339 | 0 | 2 | 5 | 1.5 | Nc1cc2c(cc1Cl)C(=O)NC1CCN(CCOCCO2)CC1 | 10.1021/jm020099f | ||
| 17754944 | 79127 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 955 | 23 | 3 | 11 | 8.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCN(CCCc2ccc(CCCN(CCCC(=O)NC3CCCCC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| CHEMBL2113291 | 79127 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 955 | 23 | 3 | 11 | 8.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCN(CCCc2ccc(CCCN(CCCC(=O)NC3CCCCC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| 53325991 | 56438 | 3 | None | - | 0 | Human | 5.4 | pKi | = | 5.4 | Functional | ChEMBL | 343 | 7 | 3 | 3 | 2.5 | O=C(O)CCCN1CCC(CNC(=O)c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL1632156 | 56438 | 3 | None | - | 0 | Human | 5.4 | pKi | = | 5.4 | Functional | ChEMBL | 343 | 7 | 3 | 3 | 2.5 | O=C(O)CCCN1CCC(CNC(=O)c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| 17756414 | 79122 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 1203 | 24 | 4 | 16 | 8.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCN(CC#Cc2cccc(C#CCN(CCCC(=O)NCC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)c2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| CHEMBL2113286 | 79122 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 1203 | 24 | 4 | 16 | 8.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCN(CC#Cc2cccc(C#CCN(CCCC(=O)NCC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)c2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| 17755039 | 79119 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 1146 | 20 | 4 | 16 | 6.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CN(CC#Cc2ccc(C#CCN(CC(=O)NCC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| CHEMBL2113283 | 79119 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 1146 | 20 | 4 | 16 | 6.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CN(CC#Cc2ccc(C#CCN(CC(=O)NCC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| 235 | 2564 | 42 | None | -5 | 3 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm070552t | ||
| 5311299 | 2564 | 42 | None | -5 | 3 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm070552t | ||
| CHEMBL286136 | 2564 | 42 | None | -5 | 3 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm070552t | ||
| 11643822 | 157859 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 1158 | 38 | 6 | 15 | 8.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCN(CCCCCCCCCCC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC(=O)NCC2CCNCC2)CC1 | 10.1021/jm070552t | ||
| CHEMBL408379 | 157859 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 1158 | 38 | 6 | 15 | 8.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCN(CCCCCCCCCCC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC(=O)NCC2CCNCC2)CC1 | 10.1021/jm070552t | ||
| 10666935 | 207950 | 0 | None | - | 0 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 371 | 5 | 1 | 6 | 1.7 | CC(C)N1CCN(CCNC(=O)n2c(=O)n(C3CC3)c3ccccc32)CC1 | 10.1021/jm020099f | ||
| CHEMBL97019 | 207950 | 0 | None | - | 0 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 371 | 5 | 1 | 6 | 1.7 | CC(C)N1CCN(CCNC(=O)n2c(=O)n(C3CC3)c3ccccc32)CC1 | 10.1021/jm020099f | ||
| 11513350 | 143916 | 0 | None | - | 0 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 778 | 18 | 4 | 12 | 4.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm070552t | ||
| CHEMBL390205 | 143916 | 0 | None | - | 0 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 778 | 18 | 4 | 12 | 4.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm070552t | ||
| 243 | 3202 | 91 | None | 1 | 5 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/jm020099f | ||
| 3052762 | 3202 | 91 | None | 1 | 5 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/jm020099f | ||
| 3502 | 3202 | 91 | None | 1 | 5 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/jm020099f | ||
| CHEMBL117287 | 3202 | 91 | None | 1 | 5 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/jm020099f | ||
| DB06480 | 3202 | 91 | None | 1 | 5 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/jm020099f | ||
| 17756314 | 79120 | 0 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 1175 | 22 | 4 | 16 | 7.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCN(CC#Cc2cccc(C#CCN(CCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)c2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| CHEMBL2113284 | 79120 | 0 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 1175 | 22 | 4 | 16 | 7.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCN(CC#Cc2cccc(C#CCN(CCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)c2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| 11714901 | 134332 | 0 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 904 | 27 | 4 | 12 | 7.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCNC(=O)CCCCCCCCCCC(=O)NCCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm070552t | ||
| CHEMBL371718 | 134332 | 0 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 904 | 27 | 4 | 12 | 7.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCNC(=O)CCCCCCCCCCC(=O)NCCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm070552t | ||
| 10688893 | 208387 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 345 | 4 | 1 | 6 | 1.2 | CC(C)n1c(=O)n(C(=O)NCCN2CCN(C)CC2)c2ccccc21 | 10.1021/jm020099f | ||
| CHEMBL99591 | 208387 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 345 | 4 | 1 | 6 | 1.2 | CC(C)n1c(=O)n(C(=O)NCCN2CCN(C)CC2)c2ccccc21 | 10.1021/jm020099f | ||
| 1782 | 2518 | 84 | None | -3 | 13 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 241 | 2518 | 84 | None | -3 | 13 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 4168 | 2518 | 84 | None | -3 | 13 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| CHEMBL86 | 2518 | 84 | None | -3 | 13 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| DB01233 | 2518 | 84 | None | -3 | 13 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 243 | 3202 | 91 | None | -1 | 5 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
| 3052762 | 3202 | 91 | None | -1 | 5 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
| 3502 | 3202 | 91 | None | -1 | 5 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
| CHEMBL117287 | 3202 | 91 | None | -1 | 5 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
| DB06480 | 3202 | 91 | None | -1 | 5 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
| 133076 | 3399 | 6 | None | 1 | 2 | Rat | 8.8 | pEC50 | = | 8.8 | Functional | Guide to Pharmacology | 417 | 9 | 2 | 6 | 2.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CCNS(=O)(=O)C)Cl | 8903510 | ||
| 3230 | 3399 | 6 | None | 1 | 2 | Rat | 8.8 | pEC50 | = | 8.8 | Functional | Guide to Pharmacology | 417 | 9 | 2 | 6 | 2.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CCNS(=O)(=O)C)Cl | 8903510 | ||
| CHEMBL83899 | 3399 | 6 | None | 1 | 2 | Rat | 8.8 | pEC50 | = | 8.8 | Functional | Guide to Pharmacology | 417 | 9 | 2 | 6 | 2.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CCNS(=O)(=O)C)Cl | 8903510 | ||
| 4223 | 3992 | 94 | None | -177 | 16 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| 6918314 | 3992 | 94 | None | -177 | 16 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| 7427 | 3992 | 94 | None | -177 | 16 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| CHEMBL439849 | 3992 | 94 | None | -177 | 16 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| DB06684 | 3992 | 94 | None | -177 | 16 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| 4223 | 3992 | 94 | None | -177 | 16 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| 6918314 | 3992 | 94 | None | -177 | 16 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| 7427 | 3992 | 94 | None | -177 | 16 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| CHEMBL439849 | 3992 | 94 | None | -177 | 16 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| DB06684 | 3992 | 94 | None | -177 | 16 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| 4223 | 3992 | 94 | None | -177 | 16 | Human | 6.6 | pIC50 | = | 6.6 | Functional | Guide to Pharmacology | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 15341484 | ||
| 6918314 | 3992 | 94 | None | -177 | 16 | Human | 6.6 | pIC50 | = | 6.6 | Functional | Guide to Pharmacology | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 15341484 | ||
| 7427 | 3992 | 94 | None | -177 | 16 | Human | 6.6 | pIC50 | = | 6.6 | Functional | Guide to Pharmacology | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 15341484 | ||
| CHEMBL439849 | 3992 | 94 | None | -177 | 16 | Human | 6.6 | pIC50 | = | 6.6 | Functional | Guide to Pharmacology | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 15341484 | ||
| DB06684 | 3992 | 94 | None | -177 | 16 | Human | 6.6 | pIC50 | = | 6.6 | Functional | Guide to Pharmacology | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 15341484 | ||
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Similar- ity |
Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
Assay Type |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
| 145973928 | 164569 | 0 | None | - | 0 | Human | 10.0 | pEC50 | = | 10 | Binding | ChEMBL | 398 | 6 | 1 | 5 | 3.3 | CC(C)c1cc2cccc(C(=O)NCC3CCN(CC4CCOCC4)CC3)n2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4215329 | 164569 | 0 | None | - | 0 | Human | 10.0 | pEC50 | = | 10 | Binding | ChEMBL | 398 | 6 | 1 | 5 | 3.3 | CC(C)c1cc2cccc(C(=O)NCC3CCN(CC4CCOCC4)CC3)n2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| 53354764 | 3064 | 34 | None | 1 | 2 | Human | 9.6 | pEC50 | = | 9.6 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/acs.jmedchem.8b00457 | |||
| 9059 | 3064 | 34 | None | 1 | 2 | Human | 9.6 | pEC50 | = | 9.6 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL2152922 | 3064 | 34 | None | 1 | 2 | Human | 9.6 | pEC50 | = | 9.6 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/acs.jmedchem.8b00457 | |||
| DB12675 | 3064 | 34 | None | 1 | 2 | Human | 9.6 | pEC50 | = | 9.6 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/acs.jmedchem.8b00457 | |||
| 145975193 | 163871 | 0 | None | - | 0 | Human | 9.5 | pEC50 | = | 9.5 | Binding | ChEMBL | 372 | 8 | 1 | 5 | 2.9 | COCCCN1CCC(CNC(=O)c2cccc3cc(C(C)C)nn23)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4206847 | 163871 | 0 | None | - | 0 | Human | 9.5 | pEC50 | = | 9.5 | Binding | ChEMBL | 372 | 8 | 1 | 5 | 2.9 | COCCCN1CCC(CNC(=O)c2cccc3cc(C(C)C)nn23)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| 145973097 | 164718 | 0 | None | - | 0 | Human | 9.5 | pEC50 | = | 9.5 | Binding | ChEMBL | 412 | 6 | 2 | 5 | 3.6 | CC(C)c1cn2cccc(C(=O)NCC3CCN(CC4(O)CCCCC4)CC3)c2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4217381 | 164718 | 0 | None | - | 0 | Human | 9.5 | pEC50 | = | 9.5 | Binding | ChEMBL | 412 | 6 | 2 | 5 | 3.6 | CC(C)c1cn2cccc(C(=O)NCC3CCN(CC4(O)CCCCC4)CC3)c2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| 145965246 | 164221 | 0 | None | - | 0 | Human | 9.4 | pEC50 | = | 9.4 | Binding | ChEMBL | 414 | 6 | 2 | 6 | 2.4 | CC(C)c1cn2cccc(C(=O)NCC3CCN(CC4(O)CCOCC4)CC3)c2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4211044 | 164221 | 0 | None | - | 0 | Human | 9.4 | pEC50 | = | 9.4 | Binding | ChEMBL | 414 | 6 | 2 | 6 | 2.4 | CC(C)c1cn2cccc(C(=O)NCC3CCN(CC4(O)CCOCC4)CC3)c2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| 77105903 | 164000 | 0 | None | - | 0 | Human | 9.2 | pEC50 | = | 9.2 | Binding | ChEMBL | 398 | 6 | 1 | 5 | 3.3 | CC(C)c1cn2cccc(C(=O)NCC3CCN(CC4CCOCC4)CC3)c2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4208302 | 164000 | 0 | None | - | 0 | Human | 9.2 | pEC50 | = | 9.2 | Binding | ChEMBL | 398 | 6 | 1 | 5 | 3.3 | CC(C)c1cn2cccc(C(=O)NCC3CCN(CC4CCOCC4)CC3)c2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| 145967487 | 164400 | 0 | None | - | 0 | Human | 9.2 | pEC50 | = | 9.2 | Binding | ChEMBL | 455 | 6 | 1 | 6 | 3.4 | COC(=O)N1CCC(CN2CCC(CNC(=O)c3cccn4cc(C(C)C)nc34)CC2)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4213334 | 164400 | 0 | None | - | 0 | Human | 9.2 | pEC50 | = | 9.2 | Binding | ChEMBL | 455 | 6 | 1 | 6 | 3.4 | COC(=O)N1CCC(CN2CCC(CNC(=O)c3cccn4cc(C(C)C)nc34)CC2)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| 145972577 | 164617 | 0 | None | - | 0 | Human | 9.2 | pEC50 | = | 9.2 | Binding | ChEMBL | 372 | 6 | 2 | 5 | 2.7 | CC(C)c1cn2cccc(C(=O)NCC3CCN(CC(C)(C)O)CC3)c2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4216003 | 164617 | 0 | None | - | 0 | Human | 9.2 | pEC50 | = | 9.2 | Binding | ChEMBL | 372 | 6 | 2 | 5 | 2.7 | CC(C)c1cn2cccc(C(=O)NCC3CCN(CC(C)(C)O)CC3)c2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| 11350913 | 136795 | 2 | None | - | 0 | Human | 8.9 | pEC50 | = | 8.9 | Binding | ChEMBL | 430 | 5 | 2 | 7 | 2.2 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2ccccc21 | 10.1016/j.ejmech.2015.08.051 | |||
| CHEMBL3741376 | 136795 | 2 | None | - | 0 | Human | 8.9 | pEC50 | = | 8.9 | Binding | ChEMBL | 430 | 5 | 2 | 7 | 2.2 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2ccccc21 | 10.1016/j.ejmech.2015.08.051 | |||
| 53354764 | 3064 | 34 | None | 1 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/acs.jmedchem.1c00703 | |||
| 9059 | 3064 | 34 | None | 1 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL2152922 | 3064 | 34 | None | 1 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/acs.jmedchem.1c00703 | |||
| DB12675 | 3064 | 34 | None | 1 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/acs.jmedchem.1c00703 | |||
| 53354764 | 3064 | 34 | None | 1 | 2 | Human | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/acs.jmedchem.8b00457 | |||
| 9059 | 3064 | 34 | None | 1 | 2 | Human | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL2152922 | 3064 | 34 | None | 1 | 2 | Human | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/acs.jmedchem.8b00457 | |||
| DB12675 | 3064 | 34 | None | 1 | 2 | Human | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/acs.jmedchem.8b00457 | |||
| 145975035 | 163531 | 0 | None | - | 0 | Human | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 372 | 8 | 1 | 5 | 2.9 | COCCCN1CCC(CNC(=O)c2cccn3cc(C(C)C)nc23)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4202791 | 163531 | 0 | None | - | 0 | Human | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 372 | 8 | 1 | 5 | 2.9 | COCCCN1CCC(CNC(=O)c2cccn3cc(C(C)C)nc23)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| 145966407 | 164215 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 2.5 | CC(C)c1nc(C(=O)NCC2C3CN(C4CCOCC4)CC23)n2ccccc12 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4210983 | 164215 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 2.5 | CC(C)c1nc(C(=O)NCC2C3CN(C4CCOCC4)CC23)n2ccccc12 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL5283568 | 194621 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 386 | 6 | 2 | 5 | 2.9 | CC(C)n1nc(C(=O)NC2CCN(CC(C)(C)C(=O)O)CC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315410 | 194621 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 386 | 6 | 2 | 5 | 2.9 | CC(C)n1nc(C(=O)NC2CCN(CC(C)(C)C(=O)O)CC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5275962 | 194653 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 370 | 4 | 1 | 5 | 3.0 | CC(C)n1nc(C(=O)NC2CCN(C3CCOCC3)CC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315855 | 194653 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 370 | 4 | 1 | 5 | 3.0 | CC(C)n1nc(C(=O)NC2CCN(C3CCOCC3)CC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| 68592173 | 137841 | 0 | None | - | 0 | Rat | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 494 | 6 | 2 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=O)C(C)(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3759944 | 137841 | 0 | None | - | 0 | Rat | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 494 | 6 | 2 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=O)C(C)(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| 5311047 | 204763 | 33 | None | - | 1 | Rat | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL74656 | 204763 | 33 | None | - | 1 | Rat | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| 67922794 | 137720 | 0 | None | - | 0 | Rat | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 452 | 7 | 2 | 6 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCC(=O)N2CCCCC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3758945 | 137720 | 0 | None | - | 0 | Rat | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 452 | 7 | 2 | 6 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCC(=O)N2CCCCC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL5287697 | 194627 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 409 | 5 | 0 | 7 | 4.3 | CC(C)n1nc(-c2nc(C3CCN(CC4CCOCC4)CC3)no2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315464 | 194627 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 409 | 5 | 0 | 7 | 4.3 | CC(C)n1nc(-c2nc(C3CCN(CC4CCOCC4)CC3)no2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5267721 | 194639 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 409 | 7 | 0 | 7 | 4.4 | COCCCN1C2CCC1CC(c1nnc(-c3nn(C(C)C)c4ccccc34)o1)C2 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315690 | 194639 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 409 | 7 | 0 | 7 | 4.4 | COCCCN1C2CCC1CC(c1nnc(-c3nn(C(C)C)c4ccccc34)o1)C2 | 10.1021/acs.jmedchem.1c00703 | |||
| 145977971 | 164008 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 406 | 8 | 1 | 5 | 3.6 | COCCCN1CCC(CNC(=O)c2cccn3c(Cl)c(C(C)C)nc23)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4208394 | 164008 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 406 | 8 | 1 | 5 | 3.6 | COCCCN1CCC(CNC(=O)c2cccn3c(Cl)c(C(C)C)nc23)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| 10584 | 1463 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1021/acs.jmedchem.5b00115 | |||
| 86582973 | 1463 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1021/acs.jmedchem.5b00115 | |||
| CHEMBL3417009 | 1463 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1021/acs.jmedchem.5b00115 | |||
| 9975257 | 48754 | 1 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 351 | 3 | 2 | 4 | 3.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2C(C)CCCC2C1 | 10.1021/jm020099f | |||
| CHEMBL15585 | 48754 | 1 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 351 | 3 | 2 | 4 | 3.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2C(C)CCCC2C1 | 10.1021/jm020099f | |||
| 9797313 | 101929 | 2 | None | - | 2 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 323 | 3 | 2 | 4 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2C | 10.1021/jm020099f | |||
| CHEMBL301039 | 101929 | 2 | None | - | 2 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 323 | 3 | 2 | 4 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2C | 10.1021/jm020099f | |||
| 145975740 | 163987 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 396 | 6 | 1 | 5 | 2.8 | CC(C)c1cn2cccc(C(=O)NCC3C4CN(CC5CCOCC5)CC34)c2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4208144 | 163987 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 396 | 6 | 1 | 5 | 2.8 | CC(C)c1cn2cccc(C(=O)NCC3C4CN(CC5CCOCC5)CC34)c2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL5288809 | 194637 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 381 | 6 | 0 | 6 | 4.9 | CC(C)CCN1CCC(c2nnc(-c3nn(C(C)C)c4ccccc34)o2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315677 | 194637 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 381 | 6 | 0 | 6 | 4.9 | CC(C)CCN1CCC(c2nnc(-c3nn(C(C)C)c4ccccc34)o2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5289747 | 194634 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 2.7 | CC(C)n1nc(C(=O)NC2C3CN(CC4CCOCC4)CC32)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315613 | 194634 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 2.7 | CC(C)n1nc(C(=O)NC2C3CN(CC4CCOCC4)CC32)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| 9975257 | 48754 | 1 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 351 | 3 | 2 | 4 | 3.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2C(C)CCCC2C1 | 10.1021/jm020099f | |||
| CHEMBL15585 | 48754 | 1 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 351 | 3 | 2 | 4 | 3.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2C(C)CCCC2C1 | 10.1021/jm020099f | |||
| 9797313 | 101929 | 2 | None | - | 2 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 323 | 3 | 2 | 4 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2C | 10.1021/jm020099f | |||
| CHEMBL301039 | 101929 | 2 | None | - | 2 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 323 | 3 | 2 | 4 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2C | 10.1021/jm020099f | |||
| CHEMBL5270858 | 194604 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 365 | 4 | 0 | 6 | 4.4 | CC(C)n1nc(-c2nnc(C3CCN(C4CCC4)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315212 | 194604 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 365 | 4 | 0 | 6 | 4.4 | CC(C)n1nc(-c2nnc(C3CCN(C4CCC4)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| 145973946 | 164611 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1CC2C(CNC(=O)c3nc(C(C)C)c4ccccn34)C2C1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4215943 | 164611 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1CC2C(CNC(=O)c3nc(C(C)C)c4ccccn34)C2C1 | 10.1021/acs.jmedchem.8b00457 | |||
| 145978459 | 163577 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1CC2C(CNC(=O)c3cccn4cc(C(C)C)nc34)C2C1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4203277 | 163577 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1CC2C(CNC(=O)c3cccn4cc(C(C)C)nc34)C2C1 | 10.1021/acs.jmedchem.8b00457 | |||
| 10521792 | 110591 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 349 | 4 | 2 | 4 | 2.6 | Nc1c(Cl)cc(C(=O)NCCC23CCCN2CCC3)c2c1CCO2 | 10.1021/jm020099f | |||
| CHEMBL325494 | 110591 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 349 | 4 | 2 | 4 | 2.6 | Nc1c(Cl)cc(C(=O)NCCC23CCCN2CCC3)c2c1CCO2 | 10.1021/jm020099f | |||
| CHEMBL5286277 | 194631 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 384 | 5 | 1 | 5 | 3.2 | CC(C)n1nc(C(=O)NC2CCN(CC3CCOCC3)CC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315498 | 194631 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 384 | 5 | 1 | 5 | 3.2 | CC(C)n1nc(C(=O)NC2CCN(CC3CCOCC3)CC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5267237 | 194635 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 384 | 5 | 2 | 5 | 3.1 | CC(C)n1nc(C(=O)NC2CC3CCC(C2)N3CC(C)(C)O)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315650 | 194635 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 384 | 5 | 2 | 5 | 3.1 | CC(C)n1nc(C(=O)NC2CC3CCC(C2)N3CC(C)(C)O)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5272596 | 194620 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 369 | 6 | 0 | 7 | 3.5 | COCCN1CCC(c2nnc(-c3nn(C(C)C)c4ccccc34)o2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315395 | 194620 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 369 | 6 | 0 | 7 | 3.5 | COCCN1CCC(c2nnc(-c3nn(C(C)C)c4ccccc34)o2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5275060 | 194644 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 400 | 5 | 2 | 6 | 2.4 | CC(C)n1nc(C(=O)NC2CCN(CC3(O)CCOCC3)CC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315752 | 194644 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 400 | 5 | 2 | 6 | 2.4 | CC(C)n1nc(C(=O)NC2CCN(CC3(O)CCOCC3)CC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| 135409453 | 3773 | 41 | None | -2 | 2 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.05.034 | |||
| 226 | 3773 | 41 | None | -2 | 2 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.05.034 | |||
| CHEMBL76370 | 3773 | 41 | None | -2 | 2 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.05.034 | |||
| CHEMBL5270036 | 194605 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 311 | 3 | 1 | 6 | 3.1 | CC(C)n1nc(-c2nnc(C3CCNCC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315255 | 194605 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 311 | 3 | 1 | 6 | 3.1 | CC(C)n1nc(-c2nnc(C3CCNCC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5277017 | 194661 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 383 | 5 | 1 | 7 | 3.6 | CC(C)n1nc(-c2nnc(C3CCN(CC(C)(C)O)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5316058 | 194661 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 383 | 5 | 1 | 7 | 3.6 | CC(C)n1nc(-c2nnc(C3CCN(CC(C)(C)O)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| 68593871 | 137764 | 0 | None | - | 0 | Rat | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 466 | 7 | 2 | 6 | 2.4 | CCC(=O)N1CCCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)C1 | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3759348 | 137764 | 0 | None | - | 0 | Rat | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 466 | 7 | 2 | 6 | 2.4 | CCC(=O)N1CCCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)C1 | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL5275605 | 193864 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.9 | COCCCN1CCC(c2nc(-c3nn(C(C)C)c4ccccc34)no2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5268064 | 194601 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 369 | 6 | 1 | 7 | 3.2 | CC(C)n1nc(-c2nnc(C3CCN(CCCO)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315175 | 194601 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 369 | 6 | 1 | 7 | 3.2 | CC(C)n1nc(-c2nnc(C3CCN(CCCO)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5286989 | 194367 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 379 | 5 | 0 | 6 | 4.6 | CC(C)n1nc(-c2nnc(C3CCN(CC4CCC4)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| 54677674 | 112809 | 4 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL3291085 | 112809 | 4 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL3306918 | 112809 | 4 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1021/acs.jmedchem.8b00457 | |||
| 145964870 | 164410 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 370 | 6 | 2 | 5 | 2.1 | CC(C)c1cn2cccc(C(=O)NCC3C4CN(CC(C)(C)O)CC34)c2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4213441 | 164410 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 370 | 6 | 2 | 5 | 2.1 | CC(C)c1cn2cccc(C(=O)NCC3C4CN(CC(C)(C)O)CC34)c2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| 54677674 | 112809 | 4 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL3291085 | 112809 | 4 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL3306918 | 112809 | 4 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5269243 | 194599 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 399 | 7 | 0 | 7 | 4.6 | CSCCCN1CCC(c2nnc(-c3nn(C(C)C)c4ccccc34)o2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315148 | 194599 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 399 | 7 | 0 | 7 | 4.6 | CSCCCN1CCC(c2nnc(-c3nn(C(C)C)c4ccccc34)o2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5283556 | 194216 | 0 | None | - | 0 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 384 | 7 | 1 | 5 | 3.4 | COCCCN1C2CCC1CC(NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5272676 | 193731 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 357 | 5 | 0 | 6 | 3.8 | CC(C)n1nc(-c2nnc(C3CCN(CCF)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5278277 | 194657 | 0 | None | - | 0 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 409 | 5 | 0 | 7 | 4.3 | CC(C)n1nc(-c2noc(C3CCN(CC4CCOCC4)CC3)n2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5316010 | 194657 | 0 | None | - | 0 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 409 | 5 | 0 | 7 | 4.3 | CC(C)n1nc(-c2noc(C3CCN(CC4CCOCC4)CC3)n2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| 145976249 | 163545 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 373 | 8 | 1 | 6 | 2.3 | COCCCN1CCC(CNC(=O)c2cccn3nc(C(C)C)nc23)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4202922 | 163545 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 373 | 8 | 1 | 6 | 2.3 | COCCCN1CCC(CNC(=O)c2cccn3nc(C(C)C)nc23)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| 145977126 | 163798 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 373 | 8 | 1 | 6 | 2.3 | COCCCN1CCC(CNC(=O)c2cccc3nc(C(C)C)nn23)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4206020 | 163798 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 373 | 8 | 1 | 6 | 2.3 | COCCCN1CCC(CNC(=O)c2cccc3nc(C(C)C)nn23)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL5283579 | 194624 | 0 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 351 | 4 | 0 | 6 | 4.0 | CC(C)n1nc(-c2nnc(C3CCN(C4CC4)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315441 | 194624 | 0 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 351 | 4 | 0 | 6 | 4.0 | CC(C)n1nc(-c2nnc(C3CCN(C4CC4)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| 183782 | 3398 | 20 | None | 69 | 13 | Human | 8.7 | pEC50 | = | 8.7 | Binding | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/acs.jmedchem.1c00703 | |||
| 237 | 3398 | 20 | None | 69 | 13 | Human | 8.7 | pEC50 | = | 8.7 | Binding | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL85251 | 3398 | 20 | None | 69 | 13 | Human | 8.7 | pEC50 | = | 8.7 | Binding | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/acs.jmedchem.1c00703 | |||
| 138376515 | 163788 | 5 | None | - | 0 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 409 | 5 | 0 | 7 | 4.1 | CC(C)c1cc2cccc(-c3nnc(C4CCN(CC5CCOCC5)CC4)o3)n2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4205936 | 163788 | 5 | None | - | 0 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 409 | 5 | 0 | 7 | 4.1 | CC(C)c1cc2cccc(-c3nnc(C4CCN(CC5CCOCC5)CC4)o3)n2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL5286257 | 194626 | 0 | None | - | 0 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 374 | 7 | 2 | 6 | 2.2 | COCCCN1CCC(O)(NC(=O)c2nn(C(C)C)c3ccccc23)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315460 | 194626 | 0 | None | - | 0 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 374 | 7 | 2 | 6 | 2.2 | COCCCN1CCC(O)(NC(=O)c2nn(C(C)C)c3ccccc23)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5287819 | 194617 | 0 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 425 | 5 | 1 | 8 | 3.4 | CC(C)n1nc(-c2nnc(C3CCN(CC4(O)CCOCC4)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315380 | 194617 | 0 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 425 | 5 | 1 | 8 | 3.4 | CC(C)n1nc(-c2nnc(C3CCN(CC4(O)CCOCC4)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| 127037818 | 136694 | 2 | None | - | 0 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1C[C@H]2[C@H](CNC(=O)c3nc(C(C)C)n4ccccc34)[C@H]2C1 | 10.1016/j.ejmech.2019.111569 | |||
| CHEMBL3740472 | 136694 | 2 | None | - | 0 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1C[C@H]2[C@H](CNC(=O)c3nc(C(C)C)n4ccccc34)[C@H]2C1 | 10.1016/j.ejmech.2019.111569 | |||
| CHEMBL5288438 | 194638 | 0 | None | - | 0 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 409 | 5 | 1 | 7 | 4.2 | CC(C)n1nc(-c2nnc(C3CCN(CC4(O)CCCC4)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315683 | 194638 | 0 | None | - | 0 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 409 | 5 | 1 | 7 | 4.2 | CC(C)n1nc(-c2nnc(C3CCN(CC4(O)CCCC4)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5285364 | 194295 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.9 | COCCCN1CCC(c2noc(-c3nn(C(C)C)c4ccccc34)n2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5290568 | 194502 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 353 | 4 | 0 | 6 | 4.3 | CC(C)N1CCC(c2nnc(-c3nn(C(C)C)c4ccccc34)o2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5275260 | 194652 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 442 | 6 | 1 | 5 | 4.1 | CC(C)n1nc(C(=O)NCC2CC3CCC(C2)N3CC2(F)CCOCC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315833 | 194652 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 442 | 6 | 1 | 5 | 4.1 | CC(C)n1nc(C(=O)NCC2CC3CCC(C2)N3CC2(F)CCOCC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5286642 | 194622 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 415 | 6 | 0 | 6 | 5.1 | CC(C)n1nc(-c2nnc(C3CCN(CCc4ccccc4)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315420 | 194622 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 415 | 6 | 0 | 6 | 5.1 | CC(C)n1nc(-c2nnc(C3CCN(CCc4ccccc4)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5290222 | 194665 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 400 | 5 | 2 | 6 | 2.6 | CC(C)n1nc(C(=O)NC2(O)CCN(CC3CCOCC3)CC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5316143 | 194665 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 400 | 5 | 2 | 6 | 2.6 | CC(C)n1nc(C(=O)NC2(O)CCN(CC3CCOCC3)CC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| 127027397 | 137630 | 0 | None | - | 0 | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 421 | 8 | 2 | 7 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCn2ccnc2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3758199 | 137630 | 0 | None | - | 0 | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 421 | 8 | 2 | 7 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCn2ccnc2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL5272764 | 194618 | 0 | None | - | 0 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 379 | 5 | 0 | 6 | 4.5 | CC(C)n1nc(-c2nnc(CC3CCN(C4CCC4)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315381 | 194618 | 0 | None | - | 0 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 379 | 5 | 0 | 6 | 4.5 | CC(C)n1nc(-c2nnc(CC3CCN(C4CCC4)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| 243 | 3202 | 91 | None | 12 | 34 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.8b00457 | |||
| 3052762 | 3202 | 91 | None | 12 | 34 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.8b00457 | |||
| 3502 | 3202 | 91 | None | 12 | 34 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL117287 | 3202 | 91 | None | 12 | 34 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.8b00457 | |||
| DB06480 | 3202 | 91 | None | 12 | 34 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.8b00457 | |||
| 243 | 3202 | 91 | None | - | 34 | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.1c00703 | |||
| 3052762 | 3202 | 91 | None | - | 34 | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.1c00703 | |||
| 3502 | 3202 | 91 | None | - | 34 | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL117287 | 3202 | 91 | None | - | 34 | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.1c00703 | |||
| DB06480 | 3202 | 91 | None | - | 34 | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5275895 | 194660 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 358 | 5 | 2 | 5 | 2.6 | CC(C)n1nc(C(=O)NC2CCN(CC(C)(C)O)CC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5316054 | 194660 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 358 | 5 | 2 | 5 | 2.6 | CC(C)n1nc(C(=O)NC2CCN(CC(C)(C)O)CC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| 145974756 | 164757 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 416 | 5 | 1 | 5 | 3.2 | CC(C)c1nn2c(C(=O)NCC3C4CN(C5CCOCC5)CC34)cccc2c1Cl | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4217842 | 164757 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 416 | 5 | 1 | 5 | 3.2 | CC(C)c1nn2c(C(=O)NCC3C4CN(C5CCOCC5)CC34)cccc2c1Cl | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL5283058 | 194642 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 358 | 7 | 1 | 5 | 2.8 | COCCCN1CCC(NC(=O)c2nn(C(C)C)c3ccccc23)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315718 | 194642 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 358 | 7 | 1 | 5 | 2.8 | COCCCN1CCC(NC(=O)c2nn(C(C)C)c3ccccc23)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5281997 | 194138 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 353 | 4 | 0 | 6 | 4.3 | CC(C)N1CCC(c2noc(-c3nn(C(C)C)c4ccccc34)n2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5274456 | 193817 | 0 | None | - | 0 | Human | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 386 | 7 | 1 | 4 | 4.1 | CC(C)n1nc(C(=O)NC2CC3CCC(C2)N3CCCCF)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5281474 | 194641 | 0 | None | - | 0 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 439 | 5 | 1 | 6 | 2.8 | COC(=O)N1CCC(N2CC3C(CNC(=O)c4nn(C(C)C)c5ccccc45)C3C2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315714 | 194641 | 0 | None | - | 0 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 439 | 5 | 1 | 6 | 2.8 | COC(=O)N1CCC(N2CC3C(CNC(=O)c4nn(C(C)C)c5ccccc45)C3C2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5276171 | 193887 | 0 | None | - | 0 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 370 | 8 | 1 | 5 | 2.6 | COCCCN1CC2C(CNC(=O)c3nn(C(C)C)c4ccccc34)C2C1 | 10.1021/acs.jmedchem.1c00703 | |||
| 44224237 | 194790 | 8 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1016/j.bmcl.2012.05.034 | |||
| CHEMBL538635 | 194790 | 8 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1016/j.bmcl.2012.05.034 | |||
| CHEMBL5270411 | 193632 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 330 | 5 | 1 | 4 | 2.2 | CC(C)n1nc(C(=O)NC2C3CN(CCF)CC32)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| 71508291 | 167436 | 12 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.9 | COCCCN1CCC(c2nnc(-c3nn(C(C)C)c4ccccc34)o2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL4297327 | 167436 | 12 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.9 | COCCCN1CCC(c2nnc(-c3nn(C(C)C)c4ccccc34)o2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5279298 | 167436 | 12 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.9 | COCCCN1CCC(c2nnc(-c3nn(C(C)C)c4ccccc34)o2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| 71508291 | 167436 | 12 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.9 | COCCCN1CCC(c2nnc(-c3nn(C(C)C)c4ccccc34)o2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL4297327 | 167436 | 12 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.9 | COCCCN1CCC(c2nnc(-c3nn(C(C)C)c4ccccc34)o2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5279298 | 167436 | 12 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.9 | COCCCN1CCC(c2nnc(-c3nn(C(C)C)c4ccccc34)o2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| 71508291 | 167436 | 12 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.9 | COCCCN1CCC(c2nnc(-c3nn(C(C)C)c4ccccc34)o2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL4297327 | 167436 | 12 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.9 | COCCCN1CCC(c2nnc(-c3nn(C(C)C)c4ccccc34)o2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5279298 | 167436 | 12 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.9 | COCCCN1CCC(c2nnc(-c3nn(C(C)C)c4ccccc34)o2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5275886 | 193874 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 402 | 5 | 1 | 5 | 3.3 | CC(C)n1nc(C(=O)NC2CCN(CC3(F)CCOCC3)CC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| 145975076 | 163622 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 340 | 5 | 1 | 4 | 2.8 | CC(C)c1cn2cccc(C(=O)NCC3C4CN(C(C)C)CC34)c2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4203778 | 163622 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 340 | 5 | 1 | 4 | 2.8 | CC(C)c1cn2cccc(C(=O)NCC3C4CN(C(C)C)CC34)c2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL5291111 | 194521 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 374 | 5 | 1 | 4 | 3.5 | CC(C)n1nc(C(=O)NC2C3CN(Cc4ccccc4)CC32)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| 145972323 | 164591 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 2.5 | CC(C)c1cn2cccc(C(=O)NCC3C4CN(C5CCOCC5)CC34)c2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4215651 | 164591 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 2.5 | CC(C)c1cn2cccc(C(=O)NCC3C4CN(C5CCOCC5)CC34)c2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| 155554403 | 174632 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 330 | 2 | 1 | 3 | 1.9 | CCN1C(=O)N(C(=O)NC2CC3CCC(C2)N3C)C2C=CC=CC21 | 10.1016/j.ejmech.2019.111569 | |||
| CHEMBL4557961 | 174632 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 330 | 2 | 1 | 3 | 1.9 | CCN1C(=O)N(C(=O)NC2CC3CCC(C2)N3C)C2C=CC=CC21 | 10.1016/j.ejmech.2019.111569 | |||
| 19426720 | 110606 | 0 | None | - | 0 | Mouse | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 342 | 2 | 1 | 5 | 2.4 | CCn1c(=O)n(C(=O)NC2CC3CCCC(C2)N3C)c2ccccc21 | 10.1021/jm020099f | |||
| CHEMBL325603 | 110606 | 0 | None | - | 0 | Mouse | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 342 | 2 | 1 | 5 | 2.4 | CCn1c(=O)n(C(=O)NC2CC3CCCC(C2)N3C)c2ccccc21 | 10.1021/jm020099f | |||
| CHEMBL5270492 | 194607 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 330 | 5 | 2 | 5 | 1.8 | CC(C)n1nc(C(=O)NC2CCN(CCO)CC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315263 | 194607 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 330 | 5 | 2 | 5 | 1.8 | CC(C)n1nc(C(=O)NC2CCN(CCO)CC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| 68592299 | 137754 | 0 | None | - | 0 | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 466 | 7 | 2 | 6 | 2.4 | CCC(=O)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3759259 | 137754 | 0 | None | - | 0 | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 466 | 7 | 2 | 6 | 2.4 | CCC(=O)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL5273433 | 193764 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 360 | 7 | 1 | 6 | 2.0 | COCCCN1CCOC(NC(=O)c2nn(C(C)C)c3ccccc23)C1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5274204 | 194651 | 0 | None | - | 0 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 426 | 5 | 2 | 6 | 2.9 | CC(C)n1nc(C(=O)NC2CC3CCC(C2)N3CC2(O)CCOCC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315832 | 194651 | 0 | None | - | 0 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 426 | 5 | 2 | 6 | 2.9 | CC(C)n1nc(C(=O)NC2CC3CCC(C2)N3CC2(O)CCOCC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5289203 | 194636 | 0 | None | - | 0 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 453 | 6 | 1 | 6 | 3.0 | COC(=O)N1CCC(CN2CC3C(CNC(=O)c4nn(C(C)C)c5ccccc45)C3C2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315653 | 194636 | 0 | None | - | 0 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 453 | 6 | 1 | 6 | 3.0 | COC(=O)N1CCC(CN2CC3C(CNC(=O)c4nn(C(C)C)c5ccccc45)C3C2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| 9800656 | 15550 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | |||
| CHEMBL121913 | 15550 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | |||
| 145975067 | 163592 | 0 | None | - | 0 | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 455 | 6 | 1 | 6 | 3.4 | COC(=O)N1CCC(CN2CCC(CNC(=O)c3nc(C(C)C)c4ccccn34)CC2)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4203491 | 163592 | 0 | None | - | 0 | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 455 | 6 | 1 | 6 | 3.4 | COC(=O)N1CCC(CN2CCC(CNC(=O)c3nc(C(C)C)c4ccccn34)CC2)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| 145964080 | 164164 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 384 | 5 | 1 | 5 | 3.1 | CC(C)c1nc(C(=O)NCC2CCN(C3CCOCC3)CC2)n2ccccc12 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4210381 | 164164 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 384 | 5 | 1 | 5 | 3.1 | CC(C)c1nc(C(=O)NCC2CCN(C3CCOCC3)CC2)n2ccccc12 | 10.1021/acs.jmedchem.8b00457 | |||
| 71508291 | 167436 | 12 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.9 | COCCCN1CCC(c2nnc(-c3nn(C(C)C)c4ccccc34)o2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL4297327 | 167436 | 12 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.9 | COCCCN1CCC(c2nnc(-c3nn(C(C)C)c4ccccc34)o2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5279298 | 167436 | 12 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.9 | COCCCN1CCC(c2nnc(-c3nn(C(C)C)c4ccccc34)o2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5281000 | 194650 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 386 | 7 | 1 | 5 | 3.5 | COCC(C)(C)CN1CCC(NC(=O)c2nn(C(C)C)c3ccccc23)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315826 | 194650 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 386 | 7 | 1 | 5 | 3.5 | COCC(C)(C)CN1CCC(NC(=O)c2nn(C(C)C)c3ccccc23)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| 25016328 | 137825 | 0 | None | - | 0 | Rat | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 480 | 7 | 2 | 6 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=O)C(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3759860 | 137825 | 0 | None | - | 0 | Rat | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 480 | 7 | 2 | 6 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=O)C(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| 145977443 | 163937 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 342 | 5 | 1 | 4 | 3.3 | CC(C)c1nc(C(=O)NCC2CCN(C(C)C)CC2)n2ccccc12 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4207586 | 163937 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 342 | 5 | 1 | 4 | 3.3 | CC(C)c1nc(C(=O)NCC2CCN(C(C)C)CC2)n2ccccc12 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL5284140 | 194612 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 372 | 6 | 2 | 5 | 2.8 | CC(C)n1nc(C(=O)NC2CCN(CC(C)(C)CO)CC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315296 | 194612 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 372 | 6 | 2 | 5 | 2.8 | CC(C)n1nc(C(=O)NC2CCN(CC(C)(C)CO)CC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5273457 | 194628 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 360 | 5 | 1 | 4 | 3.6 | CC(C)n1nc(C(=O)NC2CCN(CC(C)(C)F)CC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315474 | 194628 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 360 | 5 | 1 | 4 | 3.6 | CC(C)n1nc(C(=O)NC2CCN(CC(C)(C)F)CC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| 145978825 | 163898 | 0 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 409 | 5 | 0 | 7 | 4.1 | CC(C)c1nc(-c2nnc(C3CCN(CC4CCOCC4)CC3)o2)n2ccccc12 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4207136 | 163898 | 0 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 409 | 5 | 0 | 7 | 4.1 | CC(C)c1nc(-c2nnc(C3CCN(CC4CCOCC4)CC3)o2)n2ccccc12 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL5288891 | 194448 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 376 | 7 | 1 | 5 | 3.1 | COCCCN1CCC(F)(NC(=O)c2nn(C(C)C)c3ccccc23)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5271080 | 194603 | 0 | None | - | 0 | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 2.7 | CC(C)n1nc(C(=O)NCC2C3CN(C4CCOCC4)CC23)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315204 | 194603 | 0 | None | - | 0 | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 2.7 | CC(C)n1nc(C(=O)NCC2C3CN(C4CCOCC4)CC23)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| 243 | 3202 | 91 | None | 12 | 34 | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.8b00457 | |||
| 3052762 | 3202 | 91 | None | 12 | 34 | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.8b00457 | |||
| 3502 | 3202 | 91 | None | 12 | 34 | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL117287 | 3202 | 91 | None | 12 | 34 | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.8b00457 | |||
| DB06480 | 3202 | 91 | None | 12 | 34 | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL5274379 | 193812 | 0 | None | - | 0 | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 366 | 5 | 1 | 4 | 3.8 | CC(C)n1nc(C(=O)NC2CC3CCC(C2)N3CC2CC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5278851 | 194658 | 0 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 332 | 5 | 1 | 4 | 2.8 | CC(C)n1nc(C(=O)NC2CCN(CCF)CC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5316011 | 194658 | 0 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 332 | 5 | 1 | 4 | 2.8 | CC(C)n1nc(C(=O)NC2CCN(CCF)CC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5281078 | 194659 | 0 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 410 | 5 | 1 | 5 | 3.8 | CC(C)n1nc(C(=O)NC2CC3CCC(C2)N3CC2CCOCC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5316015 | 194659 | 0 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 410 | 5 | 1 | 5 | 3.8 | CC(C)n1nc(C(=O)NC2CC3CCC(C2)N3CC2CCOCC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5268956 | 194608 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 397 | 6 | 1 | 7 | 4.0 | CC(C)n1nc(-c2nnc(C3CCN(CCC(C)(C)O)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315264 | 194608 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 397 | 6 | 1 | 7 | 4.0 | CC(C)n1nc(-c2nnc(C3CCN(CCC(C)(C)O)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| 145975297 | 163593 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 353 | 4 | 0 | 6 | 4.1 | CC(C)c1cc2cccc(-c3nnc(C4CCN(C(C)C)CC4)o3)n2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4203494 | 163593 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 353 | 4 | 0 | 6 | 4.1 | CC(C)c1cc2cccc(-c3nnc(C4CCN(C(C)C)CC4)o3)n2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL5282103 | 194655 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 365 | 5 | 0 | 6 | 4.1 | CC(C)n1nc(-c2nnc(CC3CCN(C4CC4)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315948 | 194655 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 365 | 5 | 0 | 6 | 4.1 | CC(C)n1nc(-c2nnc(CC3CCN(C4CC4)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| 54677674 | 112809 | 4 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL3291085 | 112809 | 4 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL3306918 | 112809 | 4 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1021/acs.jmedchem.8b00457 | |||
| 54677674 | 112809 | 4 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL3291085 | 112809 | 4 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL3306918 | 112809 | 4 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5278176 | 194646 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 411 | 7 | 0 | 7 | 4.5 | COCC(C)(C)CN1CCC(c2nnc(-c3nn(C(C)C)c4ccccc34)o2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315756 | 194646 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 411 | 7 | 0 | 7 | 4.5 | COCC(C)(C)CN1CCC(c2nnc(-c3nn(C(C)C)c4ccccc34)o2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| 145966243 | 164360 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 409 | 5 | 0 | 7 | 4.1 | CC(C)c1cn2cccc(-c3nnc(C4CCN(CC5CCOCC5)CC4)o3)c2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4212757 | 164360 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 409 | 5 | 0 | 7 | 4.1 | CC(C)c1cn2cccc(-c3nnc(C4CCN(CC5CCOCC5)CC4)o3)c2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| 138376515 | 163788 | 5 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 409 | 5 | 0 | 7 | 4.1 | CC(C)c1cc2cccc(-c3nnc(C4CCN(CC5CCOCC5)CC4)o3)n2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4205936 | 163788 | 5 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 409 | 5 | 0 | 7 | 4.1 | CC(C)c1cc2cccc(-c3nnc(C4CCN(CC5CCOCC5)CC4)o3)n2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| 145972573 | 164609 | 0 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.7 | COCCCN1CCC(c2nnc(-c3cccc4cc(C(C)C)nn34)o2)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4215911 | 164609 | 0 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.7 | COCCCN1CCC(c2nnc(-c3cccc4cc(C(C)C)nn34)o2)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| 138376515 | 163788 | 5 | None | - | 0 | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 409 | 5 | 0 | 7 | 4.1 | CC(C)c1cc2cccc(-c3nnc(C4CCN(CC5CCOCC5)CC4)o3)n2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4205936 | 163788 | 5 | None | - | 0 | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 409 | 5 | 0 | 7 | 4.1 | CC(C)c1cc2cccc(-c3nnc(C4CCN(CC5CCOCC5)CC4)o3)n2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| 145972573 | 164609 | 0 | None | - | 0 | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.7 | COCCCN1CCC(c2nnc(-c3cccc4cc(C(C)C)nn34)o2)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4215911 | 164609 | 0 | None | - | 0 | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.7 | COCCCN1CCC(c2nnc(-c3cccc4cc(C(C)C)nn34)o2)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| 11225102 | 76424 | 3 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 466 | 6 | 1 | 6 | 2.5 | CC(=O)N1CCN(CCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2nn(C(C)C)c4ccccc24)C3)CC1 | 10.1016/j.bmcl.2012.05.034 | |||
| CHEMBL2059590 | 76424 | 3 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 466 | 6 | 1 | 6 | 2.5 | CC(=O)N1CCN(CCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2nn(C(C)C)c4ccccc24)C3)CC1 | 10.1016/j.bmcl.2012.05.034 | |||
| CHEMBL5280851 | 194647 | 0 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 344 | 6 | 2 | 5 | 2.2 | CC(C)n1nc(C(=O)NC2CCN(CCCO)CC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315805 | 194647 | 0 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 344 | 6 | 2 | 5 | 2.2 | CC(C)n1nc(C(=O)NC2CCN(CCCO)CC2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| 127027375 | 137840 | 0 | None | - | 0 | Rat | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 542 | 9 | 2 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCC(=O)N2CCC(Cc3ccccc3)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3759928 | 137840 | 0 | None | - | 0 | Rat | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 542 | 9 | 2 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCC(=O)N2CCC(Cc3ccccc3)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL5267529 | 194633 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 386 | 5 | 1 | 4 | 4.1 | CC(C)n1nc(C(=O)NC2CC3CCC(C2)N3CC(C)(C)F)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315542 | 194633 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 386 | 5 | 1 | 4 | 4.1 | CC(C)n1nc(C(=O)NC2CC3CCC(C2)N3CC(C)(C)F)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| 145972573 | 164609 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.7 | COCCCN1CCC(c2nnc(-c3cccc4cc(C(C)C)nn34)o2)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4215911 | 164609 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.7 | COCCCN1CCC(c2nnc(-c3cccc4cc(C(C)C)nn34)o2)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| 145978541 | 163745 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 372 | 8 | 1 | 5 | 2.9 | COCCCN1CCC(CNC(=O)c2nc(C(C)C)c3ccccn23)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4205387 | 163745 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 372 | 8 | 1 | 5 | 2.9 | COCCCN1CCC(CNC(=O)c2nc(C(C)C)c3ccccn23)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| 9800656 | 15550 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | |||
| CHEMBL121913 | 15550 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | |||
| CHEMBL5286398 | 194344 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 365 | 5 | 0 | 6 | 4.3 | CC(C)n1nc(-c2nnc(C3CCN(CC4CC4)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5288222 | 194411 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 399 | 7 | 1 | 8 | 3.0 | COCCCN1CCC(O)(c2nnc(-c3nn(C(C)C)c4ccccc34)o2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| 68592484 | 137718 | 0 | None | - | 0 | Rat | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 420 | 8 | 2 | 6 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCn2cccc2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3758932 | 137718 | 0 | None | - | 0 | Rat | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 420 | 8 | 2 | 6 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCn2cccc2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| 145968234 | 164782 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.7 | COCCCN1CCC(c2nnc(-c3cccn4cc(C(C)C)nc34)o2)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4218152 | 164782 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.7 | COCCCN1CCC(c2nnc(-c3cccn4cc(C(C)C)nc34)o2)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL5276881 | 194649 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 351 | 3 | 0 | 6 | 4.0 | CC(C)n1nc(-c2nnc(C3CC4CCC(C3)N4C)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315816 | 194649 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 351 | 3 | 0 | 6 | 4.0 | CC(C)n1nc(-c2nnc(C3CC4CCC(C3)N4C)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| 145966863 | 164145 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1CC2C(CNC(=O)c3cccc4cc(C(C)C)nn34)C2C1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4210176 | 164145 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1CC2C(CNC(=O)c3cccc4cc(C(C)C)nn34)C2C1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL5287000 | 194369 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 358 | 5 | 1 | 4 | 3.3 | CC(C)n1nc(C(=O)NC2CC3CCC(C2)N3CCF)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| 68593479 | 137799 | 0 | None | - | 0 | Rat | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 422 | 8 | 2 | 8 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCn2cncn2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3759601 | 137799 | 0 | None | - | 0 | Rat | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 422 | 8 | 2 | 8 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCn2cncn2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| 155558212 | 174726 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 344 | 2 | 1 | 3 | 2.3 | CC(C)N1C(=O)N(C(=O)NC2CC3CCC(C2)N3C)C2C=CC=CC21 | 10.1016/j.ejmech.2019.111569 | |||
| CHEMBL4560185 | 174726 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 344 | 2 | 1 | 3 | 2.3 | CC(C)N1C(=O)N(C(=O)NC2CC3CCC(C2)N3C)C2C=CC=CC21 | 10.1016/j.ejmech.2019.111569 | |||
| CHEMBL5286814 | 194358 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 379 | 4 | 0 | 6 | 4.8 | CC(C)n1nc(-c2nnc(C3CCN(C4CCCC4)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| 44343153 | 110347 | 0 | None | - | 0 | Mouse | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 356 | 2 | 1 | 5 | 3.0 | CC(C)n1c(=O)n(C(=O)NC2CC3CCCC(C2)N3C)c2ccccc21 | 10.1021/jm020099f | |||
| CHEMBL324057 | 110347 | 0 | None | - | 0 | Mouse | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 356 | 2 | 1 | 5 | 3.0 | CC(C)n1c(=O)n(C(=O)NC2CC3CCCC(C2)N3C)c2ccccc21 | 10.1021/jm020099f | |||
| 9975257 | 48754 | 1 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 351 | 3 | 2 | 4 | 3.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2C(C)CCCC2C1 | 10.1021/jm020099f | |||
| CHEMBL15585 | 48754 | 1 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 351 | 3 | 2 | 4 | 3.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2C(C)CCCC2C1 | 10.1021/jm020099f | |||
| 9797313 | 101929 | 2 | None | - | 2 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 323 | 3 | 2 | 4 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2C | 10.1021/jm020099f | |||
| CHEMBL301039 | 101929 | 2 | None | - | 2 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 323 | 3 | 2 | 4 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2C | 10.1021/jm020099f | |||
| 145978151 | 163927 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 353 | 4 | 0 | 6 | 4.1 | CC(C)c1nc(-c2nnc(C3CCN(C(C)C)CC3)o2)n2ccccc12 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4207406 | 163927 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 353 | 4 | 0 | 6 | 4.1 | CC(C)c1nc(-c2nnc(C3CCN(C(C)C)CC3)o2)n2ccccc12 | 10.1021/acs.jmedchem.8b00457 | |||
| 145964746 | 164150 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 399 | 6 | 1 | 6 | 2.7 | CC(C)c1nc2c(C(=O)NCC3CCN(CC4CCOCC4)CC3)cccn2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4210213 | 164150 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 399 | 6 | 1 | 6 | 2.7 | CC(C)c1nc2c(C(=O)NCC3CCN(CC4CCOCC4)CC3)cccn2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL5277726 | 193944 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 395 | 4 | 0 | 7 | 4.0 | CC(C)n1nc(-c2nnc(C3CCN(C4CCOCC4)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| 145977409 | 163856 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.7 | COCCCN1CCC(c2nnc(-c3nc(C(C)C)c4ccccn34)o2)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4206608 | 163856 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.7 | COCCCN1CCC(c2nnc(-c3nc(C(C)C)c4ccccn34)o2)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| 145978067 | 163735 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 453 | 6 | 1 | 6 | 2.8 | COC(=O)N1CCC(CN2CC3C(CNC(=O)c4cccc5cc(C(C)C)nn45)C3C2)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4205273 | 163735 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 453 | 6 | 1 | 6 | 2.8 | COC(=O)N1CCC(CN2CC3C(CNC(=O)c4cccc5cc(C(C)C)nn45)C3C2)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| 145965914 | 164135 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 441 | 5 | 1 | 6 | 3.1 | COC(=O)N1CCC(N2CCC(CNC(=O)c3cccn4cc(C(C)C)nc34)CC2)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4210063 | 164135 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 441 | 5 | 1 | 6 | 3.1 | COC(=O)N1CCC(N2CCC(CNC(=O)c3cccn4cc(C(C)C)nc34)CC2)CC1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL5283820 | 194230 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 353 | 4 | 0 | 6 | 4.3 | CC(C)N1CCC(c2nc(-c3nn(C(C)C)c4ccccc34)no2)CC1 | 10.1021/acs.jmedchem.1c00703 | |||
| 183782 | 3398 | 20 | None | - | 13 | Rat | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.ejmech.2015.08.051 | |||
| 237 | 3398 | 20 | None | - | 13 | Rat | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.ejmech.2015.08.051 | |||
| CHEMBL85251 | 3398 | 20 | None | - | 13 | Rat | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.ejmech.2015.08.051 | |||
| 145964157 | 164328 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 396 | 6 | 1 | 5 | 2.8 | CC(C)c1cc2cccc(C(=O)NCC3C4CN(CC5CCOCC5)CC34)n2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4212433 | 164328 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 396 | 6 | 1 | 5 | 2.8 | CC(C)c1cc2cccc(C(=O)NCC3C4CN(CC5CCOCC5)CC34)n2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| 145977034 | 163616 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 398 | 6 | 1 | 5 | 3.3 | CC(C)c1nc(C(=O)NCC2CCN(CC3CCOCC3)CC2)n2ccccc12 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4203734 | 163616 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 398 | 6 | 1 | 5 | 3.3 | CC(C)c1nc(C(=O)NCC2CCN(CC3CCOCC3)CC2)n2ccccc12 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL5290981 | 194663 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 409 | 5 | 0 | 7 | 4.3 | CC(C)n1nc(-c2nnc(C3CCN(CC4CCOCC4)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5316123 | 194663 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 409 | 5 | 0 | 7 | 4.3 | CC(C)n1nc(-c2nnc(C3CCN(CC4CCOCC4)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| 145968730 | 164840 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 342 | 5 | 1 | 4 | 3.3 | CC(C)c1cn2cccc(C(=O)NCC3CCN(C(C)C)CC3)c2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4218868 | 164840 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 342 | 5 | 1 | 4 | 3.3 | CC(C)c1cn2cccc(C(=O)NCC3CCN(C(C)C)CC3)c2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| 145974160 | 164580 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 342 | 5 | 1 | 4 | 3.3 | CC(C)c1cc2cccc(C(=O)NCC3CCN(C(C)C)CC3)n2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL4215511 | 164580 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 342 | 5 | 1 | 4 | 3.3 | CC(C)c1cc2cccc(C(=O)NCC3CCN(C(C)C)CC3)n2n1 | 10.1021/acs.jmedchem.8b00457 | |||
| CHEMBL5280230 | 194656 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6 | Binding | ChEMBL | 393 | 5 | 0 | 6 | 4.9 | CC(C)n1nc(-c2nnc(CC3CCN(C4CCCC4)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| CHEMBL5315982 | 194656 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6 | Binding | ChEMBL | 393 | 5 | 0 | 6 | 4.9 | CC(C)n1nc(-c2nnc(CC3CCN(C4CCCC4)CC3)o2)c2ccccc21 | 10.1021/acs.jmedchem.1c00703 | |||
| 15166837 | 122388 | 0 | None | - | 1 | Rat | 5.9 | pED50 | = | 5.9 | Binding | ChEMBL | 337 | 5 | 2 | 4 | 2.5 | CCOc1cc(N)c(Cl)cc1C(=O)NCC1CCN2CCCC12 | 10.1021/jm00086a019 | |||
| CHEMBL36005 | 122388 | 0 | None | - | 1 | Rat | 5.9 | pED50 | = | 5.9 | Binding | ChEMBL | 337 | 5 | 2 | 4 | 2.5 | CCOc1cc(N)c(Cl)cc1C(=O)NCC1CCN2CCCC12 | 10.1021/jm00086a019 | |||
| 5 | 139 | 72 | None | -117 | 54 | Rat | 7.8 | pED50 | = | 7.8 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00086a019 | |||
| 5202 | 139 | 72 | None | -117 | 54 | Rat | 7.8 | pED50 | = | 7.8 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00086a019 | |||
| CHEMBL39 | 139 | 72 | None | -117 | 54 | Rat | 7.8 | pED50 | = | 7.8 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00086a019 | |||
| DB08839 | 139 | 72 | None | -117 | 54 | Rat | 7.8 | pED50 | = | 7.8 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00086a019 | |||
| 57391435 | 67731 | 0 | None | - | 0 | Rat | 6.8 | pED50 | = | 6.8 | Binding | ChEMBL | 307 | 3 | 2 | 4 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@]12CN3CCC1C2C3 | 10.1021/jm00086a019 | |||
| CHEMBL1907770 | 67731 | 0 | None | - | 0 | Rat | 6.8 | pED50 | = | 6.8 | Binding | ChEMBL | 307 | 3 | 2 | 4 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@]12CN3CCC1C2C3 | 10.1021/jm00086a019 | |||
| 15166838 | 41692 | 0 | None | - | 0 | Rat | 6.7 | pED50 | = | 6.7 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.9 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCCC12 | 10.1021/jm00086a019 | |||
| CHEMBL14923 | 41692 | 0 | None | - | 0 | Rat | 6.7 | pED50 | = | 6.7 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.9 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCCC12 | 10.1021/jm00086a019 | |||
| 10358856 | 120188 | 0 | None | - | 1 | Rat | 5.6 | pED50 | = | 5.6 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.3 | CCOc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCCC12 | 10.1021/jm00086a019 | |||
| CHEMBL35180 | 120188 | 0 | None | - | 1 | Rat | 5.6 | pED50 | = | 5.6 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.3 | CCOc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCCC12 | 10.1021/jm00086a019 | |||
| 132337 | 3543 | 15 | None | - | 1 | Rat | 7.6 | pED50 | = | 7.6 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1021/jm00086a019 | |||
| 238 | 3543 | 15 | None | - | 1 | Rat | 7.6 | pED50 | = | 7.6 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1021/jm00086a019 | |||
| CHEMBL34291 | 3543 | 15 | None | - | 1 | Rat | 7.6 | pED50 | = | 7.6 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1021/jm00086a019 | |||
| 1782 | 2518 | 84 | None | -11 | 22 | Rat | 4.6 | pED50 | = | 4.6 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm00086a019 | |||
| 241 | 2518 | 84 | None | -11 | 22 | Rat | 4.6 | pED50 | = | 4.6 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm00086a019 | |||
| 4168 | 2518 | 84 | None | -11 | 22 | Rat | 4.6 | pED50 | = | 4.6 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm00086a019 | |||
| CHEMBL86 | 2518 | 84 | None | -11 | 22 | Rat | 4.6 | pED50 | = | 4.6 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm00086a019 | |||
| DB01233 | 2518 | 84 | None | -11 | 22 | Rat | 4.6 | pED50 | = | 4.6 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm00086a019 | |||
| 15095972 | 137545 | 0 | None | - | 0 | Rat | 6.6 | pED50 | = | 6.6 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN2CCCC12 | 10.1021/jm00086a019 | |||
| CHEMBL37544 | 137545 | 0 | None | - | 0 | Rat | 6.6 | pED50 | = | 6.6 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN2CCCC12 | 10.1021/jm00086a019 | |||
| 15095973 | 136268 | 0 | None | - | 0 | Rat | 6.5 | pED50 | = | 6.5 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NC[C@H]1CCN2CCC[C@H]12 | 10.1021/jm00086a019 | |||
| CHEMBL37333 | 136268 | 0 | None | - | 0 | Rat | 6.5 | pED50 | = | 6.5 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NC[C@H]1CCN2CCC[C@H]12 | 10.1021/jm00086a019 | |||
| 15166838 | 41692 | 0 | None | - | 0 | Rat | 5.5 | pED50 | = | 5.5 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.9 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCCC12 | 10.1021/jm00086a019 | |||
| CHEMBL14923 | 41692 | 0 | None | - | 0 | Rat | 5.5 | pED50 | = | 5.5 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.9 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCCC12 | 10.1021/jm00086a019 | |||
| 44283512 | 140180 | 0 | None | - | 0 | Rat | 7.4 | pED50 | = | 7.4 | Binding | ChEMBL | 341 | 3 | 0 | 5 | 3.3 | CC(C)n1c(=O)n(C(=O)CC2CC3CCC(C2)N3C)c2ccccc21 | 10.1021/jm00086a019 | |||
| CHEMBL38041 | 140180 | 0 | None | - | 0 | Rat | 7.4 | pED50 | = | 7.4 | Binding | ChEMBL | 341 | 3 | 0 | 5 | 3.3 | CC(C)n1c(=O)n(C(=O)CC2CC3CCC(C2)N3C)c2ccccc21 | 10.1021/jm00086a019 | |||
| 44374544 | 53153 | 0 | None | - | 0 | Rat | 7.4 | pED50 | = | 7.4 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCC1C2 | 10.1021/jm00086a019 | |||
| CHEMBL159825 | 53153 | 0 | None | - | 0 | Rat | 7.4 | pED50 | = | 7.4 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCC1C2 | 10.1021/jm00086a019 | |||
| 9819593 | 98804 | 3 | None | - | 1 | Rat | 6.3 | pED50 | = | 6.3 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2 | 10.1021/jm00086a019 | |||
| CHEMBL27846 | 98804 | 3 | None | - | 1 | Rat | 6.3 | pED50 | = | 6.3 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2 | 10.1021/jm00086a019 | |||
| 240 | 944 | 43 | None | -8 | 24 | Rat | 7.3 | pED50 | = | 7.3 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm00086a019 | |||
| 2769 | 944 | 43 | None | -8 | 24 | Rat | 7.3 | pED50 | = | 7.3 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm00086a019 | |||
| 44279790 | 944 | 43 | None | -8 | 24 | Rat | 7.3 | pED50 | = | 7.3 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm00086a019 | |||
| 660 | 944 | 43 | None | -8 | 24 | Rat | 7.3 | pED50 | = | 7.3 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm00086a019 | |||
| CHEMBL1729 | 944 | 43 | None | -8 | 24 | Rat | 7.3 | pED50 | = | 7.3 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm00086a019 | |||
| CHEMBL560739 | 944 | 43 | None | -8 | 24 | Rat | 7.3 | pED50 | = | 7.3 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm00086a019 | |||
| DB00604 | 944 | 43 | None | -8 | 24 | Rat | 7.3 | pED50 | = | 7.3 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm00086a019 | |||
| 15095972 | 137545 | 0 | None | - | 0 | Rat | 7.2 | pED50 | = | 7.2 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN2CCCC12 | 10.1021/jm00086a019 | |||
| CHEMBL37544 | 137545 | 0 | None | - | 0 | Rat | 7.2 | pED50 | = | 7.2 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN2CCCC12 | 10.1021/jm00086a019 | |||
| 54575167 | 152032 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 454 | 8 | 2 | 5 | 4.4 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2ccc3ccccc32)CC1 | nan | |||
| CHEMBL3967117 | 152032 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 454 | 8 | 2 | 5 | 4.4 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2ccc3ccccc32)CC1 | nan | |||
| 54575171 | 150064 | 2 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 406 | 8 | 2 | 7 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2ccnn2)CC1 | nan | |||
| CHEMBL3950712 | 150064 | 2 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 406 | 8 | 2 | 7 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2ccnn2)CC1 | nan | |||
| 54575225 | 148010 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 440 | 6 | 2 | 5 | 4.1 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2cn(C)c3ccccc23)CC1 | nan | |||
| CHEMBL3934371 | 148010 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 440 | 6 | 2 | 5 | 4.1 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2cn(C)c3ccccc23)CC1 | nan | |||
| 54575170 | 146988 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 434 | 10 | 2 | 7 | 2.8 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCCn2ccnn2)CC1 | nan | |||
| CHEMBL3926377 | 146988 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 434 | 10 | 2 | 7 | 2.8 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCCn2ccnn2)CC1 | nan | |||
| 54575227 | 142529 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 405 | 6 | 2 | 4 | 3.7 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2ccc(F)cc2)CC1 | nan | |||
| CHEMBL3890747 | 142529 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 405 | 6 | 2 | 4 | 3.7 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2ccc(F)cc2)CC1 | nan | |||
| 54575166 | 154341 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 407 | 8 | 2 | 8 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2cnnn2)CC1 | nan | |||
| CHEMBL3986866 | 154341 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 407 | 8 | 2 | 8 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2cnnn2)CC1 | nan | |||
| 54575223 | 150854 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 406 | 8 | 2 | 7 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2nccn2)CC1 | nan | |||
| CHEMBL3957180 | 150854 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 406 | 8 | 2 | 7 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2nccn2)CC1 | nan | |||
| 66780300 | 149468 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 406 | 8 | 2 | 7 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2cncn2)CC1 | nan | |||
| CHEMBL3946162 | 149468 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 406 | 8 | 2 | 7 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2cncn2)CC1 | nan | |||
| 54575168 | 147194 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 419 | 8 | 2 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2ccnc2C)CC1 | nan | |||
| CHEMBL3928124 | 147194 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 419 | 8 | 2 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2ccnc2C)CC1 | nan | |||
| 54575224 | 153822 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 388 | 6 | 2 | 5 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2cccnc2)CC1 | nan | |||
| CHEMBL3982522 | 153822 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 388 | 6 | 2 | 5 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2cccnc2)CC1 | nan | |||
| 240 | 944 | 43 | None | -11 | 24 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | nan | |||
| 2769 | 944 | 43 | None | -11 | 24 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | nan | |||
| 44279790 | 944 | 43 | None | -11 | 24 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | nan | |||
| 660 | 944 | 43 | None | -11 | 24 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | nan | |||
| CHEMBL1729 | 944 | 43 | None | -11 | 24 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | nan | |||
| CHEMBL560739 | 944 | 43 | None | -11 | 24 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | nan | |||
| DB00604 | 944 | 43 | None | -11 | 24 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | nan | |||
| 54575228 | 146187 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 403 | 6 | 3 | 5 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2ccc(O)cc2)CC1 | nan | |||
| CHEMBL3920018 | 146187 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 403 | 6 | 3 | 5 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2ccc(O)cc2)CC1 | nan | |||
| 53472864 | 145569 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 390 | 6 | 2 | 5 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2cccn2C)CC1 | nan | |||
| CHEMBL3915236 | 145569 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 390 | 6 | 2 | 5 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2cccn2C)CC1 | nan | |||
| 54575226 | 144989 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 377 | 6 | 3 | 5 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2ncc[nH]2)CC1 | nan | |||
| CHEMBL3910849 | 144989 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 377 | 6 | 3 | 5 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2ncc[nH]2)CC1 | nan | |||
| 9881053 | 120245 | 0 | None | - | 0 | Mouse | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 4.1 | CCCN1CCC(COc2nc3ccccc3c3c2CCCN3)CC1 | 10.1021/jm020954v | |||
| CHEMBL35226 | 120245 | 0 | None | - | 0 | Mouse | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 4.1 | CCCN1CCC(COc2nc3ccccc3c3c2CCCN3)CC1 | 10.1021/jm020954v | |||
| 177336 | 3120 | 50 | None | 1412 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1021/jm00024a002 | |||
| 225 | 3120 | 50 | None | 1412 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1021/jm00024a002 | |||
| CHEMBL356359 | 3120 | 50 | None | 1412 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1021/jm00024a002 | |||
| DB04873 | 3120 | 50 | None | 1412 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1021/jm00024a002 | |||
| 90666907 | 109451 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 467 | 7 | 1 | 8 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2-c2cnccn2)CC1 | 10.1039/C1MD00213A | |||
| CHEMBL3220223 | 109451 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 467 | 7 | 1 | 8 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2-c2cnccn2)CC1 | 10.1039/C1MD00213A | |||
| 155525723 | 171085 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 515 | 11 | 3 | 7 | 4.2 | COc1cc(/C=C/C(=O)NCCN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)ccc1O | 10.1016/j.ejmech.2019.111596 | |||
| CHEMBL4457426 | 171085 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 515 | 11 | 3 | 7 | 4.2 | COc1cc(/C=C/C(=O)NCCN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)ccc1O | 10.1016/j.ejmech.2019.111596 | |||
| 90644473 | 112280 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 353 | 5 | 0 | 5 | 2.7 | COc1cc2c3c(cccc3n1)C(=O)N(CCCN1CCCCC1)C2=O | 10.1016/j.ejmech.2014.05.015 | |||
| CHEMBL3291078 | 112280 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 353 | 5 | 0 | 5 | 2.7 | COc1cc2c3c(cccc3n1)C(=O)N(CCCN1CCCCC1)C2=O | 10.1016/j.ejmech.2014.05.015 | |||
| 127027374 | 137667 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 423 | 8 | 2 | 9 | 0.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCn2ncnn2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3758523 | 137667 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 423 | 8 | 2 | 9 | 0.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCn2ncnn2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| 127027397 | 137630 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 421 | 8 | 2 | 7 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCn2ccnc2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3758199 | 137630 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 421 | 8 | 2 | 7 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCn2ccnc2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| 68592173 | 137841 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 494 | 6 | 2 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=O)C(C)(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3759944 | 137841 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 494 | 6 | 2 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=O)C(C)(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| 68593479 | 137799 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 422 | 8 | 2 | 8 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCn2cncn2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3759601 | 137799 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 422 | 8 | 2 | 8 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCn2cncn2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| 68592826 | 137681 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 496 | 8 | 2 | 7 | 3.0 | CCCOC(=O)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3758641 | 137681 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 496 | 8 | 2 | 7 | 3.0 | CCCOC(=O)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | |||
| 25016328 | 137825 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 480 | 7 | 2 | 6 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=O)C(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3759860 | 137825 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 480 | 7 | 2 | 6 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=O)C(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| 155565664 | 175603 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 432 | 8 | 2 | 6 | 4.5 | COc1ccc(CN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1O | 10.1016/j.ejmech.2019.111596 | |||
| CHEMBL4580044 | 175603 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 432 | 8 | 2 | 6 | 4.5 | COc1ccc(CN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1O | 10.1016/j.ejmech.2019.111596 | |||
| 16005860 | 187406 | 7 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 388 | 5 | 1 | 2 | 4.8 | CC(C)(C)CCN1CC[C@H](CNC(=O)c2cc(Cl)cc(Cl)c2)[C@H](F)C1 | 10.1021/jm800830n | |||
| CHEMBL493677 | 187406 | 7 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 388 | 5 | 1 | 2 | 4.8 | CC(C)(C)CCN1CC[C@H](CNC(=O)c2cc(Cl)cc(Cl)c2)[C@H](F)C1 | 10.1021/jm800830n | |||
| 5 | 139 | 72 | None | -117 | 54 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm970376w | |||
| 5202 | 139 | 72 | None | -117 | 54 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm970376w | |||
| CHEMBL39 | 139 | 72 | None | -117 | 54 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm970376w | |||
| DB08839 | 139 | 72 | None | -117 | 54 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm970376w | |||
| 87509467 | 137683 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 496 | 7 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=S)C(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3758674 | 137683 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 496 | 7 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=S)C(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| 10645984 | 18817 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cccc(Cl)c2)CC1 | 10.1039/C1MD00213A | |||
| CHEMBL127876 | 18817 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cccc(Cl)c2)CC1 | 10.1039/C1MD00213A | |||
| 10645103 | 164341 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 407 | 6 | 1 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2F)CC1 | 10.1039/C1MD00213A | |||
| CHEMBL421256 | 164341 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 407 | 6 | 1 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2F)CC1 | 10.1039/C1MD00213A | |||
| 68593295 | 137787 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 480 | 8 | 2 | 6 | 2.8 | CCCC(=O)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3759546 | 137787 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 480 | 8 | 2 | 6 | 2.8 | CCCC(=O)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | |||
| 10669778 | 117475 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 419 | 7 | 1 | 7 | 2.9 | COc1ccc(N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1 | 10.1039/C1MD00213A | |||
| CHEMBL339936 | 117475 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 419 | 7 | 1 | 7 | 2.9 | COc1ccc(N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1 | 10.1039/C1MD00213A | |||
| 3019427 | 60382 | 33 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 313 | 4 | 3 | 5 | 1.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCNCC1OC | 10.1016/j.bmcl.2009.08.016 | |||
| CHEMBL1748 | 60382 | 33 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 313 | 4 | 3 | 5 | 1.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCNCC1OC | 10.1016/j.bmcl.2009.08.016 | |||
| 68593458 | 137843 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 468 | 6 | 2 | 7 | 2.2 | COC(=O)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3759969 | 137843 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 468 | 6 | 2 | 7 | 2.2 | COC(=O)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | |||
| 90644474 | 112281 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 343 | 4 | 0 | 3 | 3.7 | O=C1c2cc(Cl)nc3cccc(c23)CN1CCCN1CCCCC1 | 10.1016/j.ejmech.2014.05.015 | |||
| CHEMBL3291079 | 112281 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 343 | 4 | 0 | 3 | 3.7 | O=C1c2cc(Cl)nc3cccc(c23)CN1CCCN1CCCCC1 | 10.1016/j.ejmech.2014.05.015 | |||
| 90644470 | 112278 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 328 | 6 | 0 | 5 | 3.3 | COc1cc(C(=O)OCCCN2CCCCC2)c2ccccc2n1 | 10.1016/j.ejmech.2014.05.015 | |||
| CHEMBL3291075 | 112278 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 328 | 6 | 0 | 5 | 3.3 | COc1cc(C(=O)OCCCN2CCCCC2)c2ccccc2n1 | 10.1016/j.ejmech.2014.05.015 | |||
| 4223 | 3992 | 94 | None | - | 3 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | |||
| 6918314 | 3992 | 94 | None | - | 3 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | |||
| 7427 | 3992 | 94 | None | - | 3 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | |||
| CHEMBL439849 | 3992 | 94 | None | - | 3 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | |||
| DB06684 | 3992 | 94 | None | - | 3 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | |||
| 10550242 | 17257 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2Cl)CC1 | 10.1039/C1MD00213A | |||
| CHEMBL125670 | 17257 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2Cl)CC1 | 10.1039/C1MD00213A | |||
| 11796362 | 115101 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 419 | 7 | 1 | 7 | 2.9 | COc1cccc(N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)c1 | 10.1039/C1MD00213A | |||
| CHEMBL334325 | 115101 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 419 | 7 | 1 | 7 | 2.9 | COc1cccc(N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)c1 | 10.1039/C1MD00213A | |||
| 5 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2019.111596 | |||
| 5202 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2019.111596 | |||
| CHEMBL39 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2019.111596 | |||
| DB08839 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2019.111596 | |||
| 68592299 | 137754 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 7 | 2 | 6 | 2.4 | CCC(=O)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3759259 | 137754 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 7 | 2 | 6 | 2.4 | CCC(=O)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | |||
| 68593622 | 137653 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 482 | 7 | 2 | 7 | 2.6 | CCOC(=O)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3758398 | 137653 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 482 | 7 | 2 | 7 | 2.6 | CCOC(=O)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | |||
| 44626295 | 197774 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 531 | 8 | 3 | 7 | 3.8 | COc1cccc([C@]2(O)CCCC[C@H]2CN2CC[C@@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@@H](OC)C2)c1 | 10.1016/j.bmcl.2009.08.016 | |||
| CHEMBL571799 | 197774 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 531 | 8 | 3 | 7 | 3.8 | COc1cccc([C@]2(O)CCCC[C@H]2CN2CC[C@@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@@H](OC)C2)c1 | 10.1016/j.bmcl.2009.08.016 | |||
| 90644475 | 112282 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 357 | 4 | 0 | 4 | 3.4 | O=C1c2cccc3nc(Cl)cc(c23)C(=O)N1CCCN1CCCCC1 | 10.1016/j.ejmech.2014.05.015 | |||
| CHEMBL3291080 | 112282 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 357 | 4 | 0 | 4 | 3.4 | O=C1c2cccc3nc(Cl)cc(c23)C(=O)N1CCCN1CCCCC1 | 10.1016/j.ejmech.2014.05.015 | |||
| 45485653 | 197584 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 531 | 8 | 3 | 7 | 3.8 | COc1cccc([C@]2(O)CCCC[C@H]2CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)c1 | 10.1016/j.bmcl.2009.08.016 | |||
| CHEMBL570487 | 197584 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 531 | 8 | 3 | 7 | 3.8 | COc1cccc([C@]2(O)CCCC[C@H]2CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)c1 | 10.1016/j.bmcl.2009.08.016 | |||
| 5311047 | 204763 | 33 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL74656 | 204763 | 33 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| 182593 | 3395 | 6 | None | 2 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1016/j.ejmech.2014.05.015 | |||
| 254 | 3395 | 6 | None | 2 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1016/j.ejmech.2014.05.015 | |||
| CHEMBL83954 | 3395 | 6 | None | 2 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1016/j.ejmech.2014.05.015 | |||
| 68593871 | 137764 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 466 | 7 | 2 | 6 | 2.4 | CCC(=O)N1CCCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)C1 | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3759348 | 137764 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 466 | 7 | 2 | 6 | 2.4 | CCC(=O)N1CCCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)C1 | 10.1016/j.ejmech.2015.12.006 | |||
| 45485563 | 197800 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 475 | 9 | 3 | 6 | 3.7 | COc1cccc([C@@]2(O)CCCC[C@@H]2CN(C)CCNC(=O)c2cc(Cl)c(N)cc2OC)c1 | 10.1016/j.bmcl.2009.08.016 | |||
| CHEMBL572038 | 197800 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 475 | 9 | 3 | 6 | 3.7 | COc1cccc([C@@]2(O)CCCC[C@@H]2CN(C)CCNC(=O)c2cc(Cl)c(N)cc2OC)c1 | 10.1016/j.bmcl.2009.08.016 | |||
| 68592632 | 137815 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 481 | 6 | 2 | 6 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=O)N(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3759759 | 137815 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 481 | 6 | 2 | 6 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=O)N(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| 67922794 | 137720 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 452 | 7 | 2 | 6 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCC(=O)N2CCCCC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3758945 | 137720 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 452 | 7 | 2 | 6 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCC(=O)N2CCCCC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| 68593774 | 137693 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 406 | 7 | 2 | 6 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCn2cccc2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3758721 | 137693 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 406 | 7 | 2 | 6 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCn2cccc2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| 68591735 | 137766 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 452 | 6 | 2 | 6 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(C)=O)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3759362 | 137766 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 452 | 6 | 2 | 6 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(C)=O)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| 87509988 | 137652 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 482 | 7 | 2 | 6 | 3.2 | CCC(=S)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3758397 | 137652 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 482 | 7 | 2 | 6 | 3.2 | CCC(=S)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | |||
| 45485620 | 197420 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 531 | 8 | 3 | 7 | 3.8 | COc1cccc([C@@]2(O)CCCC[C@@H]2CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)c1 | 10.1016/j.bmcl.2009.08.016 | |||
| CHEMBL569585 | 197420 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 531 | 8 | 3 | 7 | 3.8 | COc1cccc([C@@]2(O)CCCC[C@@H]2CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)c1 | 10.1016/j.bmcl.2009.08.016 | |||
| 10812045 | 15521 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 419 | 7 | 1 | 7 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2OC)CC1 | 10.1039/C1MD00213A | |||
| CHEMBL121766 | 15521 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 419 | 7 | 1 | 7 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2OC)CC1 | 10.1039/C1MD00213A | |||
| 68592484 | 137718 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 420 | 8 | 2 | 6 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCn2cccc2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3758932 | 137718 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 420 | 8 | 2 | 6 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCn2cccc2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| 127027375 | 137840 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 542 | 9 | 2 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCC(=O)N2CCC(Cc3ccccc3)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3759928 | 137840 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 542 | 9 | 2 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCC(=O)N2CCC(Cc3ccccc3)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| 25016330 | 137643 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 480 | 7 | 2 | 6 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CCN(CC2CCN(C(=O)C(C)C)CC2)C[C@@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3758309 | 137643 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 480 | 7 | 2 | 6 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CCN(CC2CCN(C(=O)C(C)C)CC2)C[C@@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| 155543353 | 173301 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 418 | 7 | 3 | 6 | 4.2 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(Cc2ccc(O)c(O)c2)CC1 | 10.1016/j.ejmech.2019.111596 | |||
| CHEMBL4526049 | 173301 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 418 | 7 | 3 | 6 | 4.2 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(Cc2ccc(O)c(O)c2)CC1 | 10.1016/j.ejmech.2019.111596 | |||
| 10717193 | 16782 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1039/C1MD00213A | |||
| CHEMBL124485 | 16782 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1039/C1MD00213A | |||
| 68592631 | 137724 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 495 | 7 | 3 | 6 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=O)NC(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3758976 | 137724 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 495 | 7 | 3 | 6 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=O)NC(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| 68593153 | 137659 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 494 | 8 | 2 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=O)CC(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3758433 | 137659 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 494 | 8 | 2 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=O)CC(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| 68593732 | 137823 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 480 | 8 | 2 | 6 | 2.8 | CCC(=O)N1CCC(CCN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3759824 | 137823 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 480 | 8 | 2 | 6 | 2.8 | CCC(=O)N1CCC(CCN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | |||
| 90644472 | 112279 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 339 | 5 | 0 | 4 | 3.1 | COc1cc2c3c(cccc3n1)CN(CCCN1CCCCC1)C2=O | 10.1016/j.ejmech.2014.05.015 | |||
| CHEMBL3291077 | 112279 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 339 | 5 | 0 | 4 | 3.1 | COc1cc2c3c(cccc3n1)CN(CCCN1CCCCC1)C2=O | 10.1016/j.ejmech.2014.05.015 | |||
| 127028946 | 137674 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 438 | 7 | 2 | 6 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCC(=O)N2CCCC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3758578 | 137674 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 438 | 7 | 2 | 6 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCC(=O)N2CCCC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| 127027702 | 137656 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 454 | 7 | 2 | 7 | 1.0 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCC(=O)N2CCOCC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| CHEMBL3758410 | 137656 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 454 | 7 | 2 | 7 | 1.0 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCC(=O)N2CCOCC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | |||
| 44626294 | 198999 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 517 | 7 | 4 | 7 | 3.5 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(C[C@@H]2CCCC[C@@]2(O)c2cccc(O)c2)C[C@H]1OC | 10.1016/j.bmcl.2009.08.016 | |||
| CHEMBL585567 | 198999 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 517 | 7 | 4 | 7 | 3.5 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(C[C@@H]2CCCC[C@@]2(O)c2cccc(O)c2)C[C@H]1OC | 10.1016/j.bmcl.2009.08.016 | |||
| 257 | 3493 | 13 | None | 1 | 3 | Rat | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 474 | 6 | 1 | 6 | 3.3 | CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N | 10.1016/j.bmcl.2013.09.097 | |||
| 5311423 | 3493 | 13 | None | 1 | 3 | Rat | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 474 | 6 | 1 | 6 | 3.3 | CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N | 10.1016/j.bmcl.2013.09.097 | |||
| CHEMBL114112 | 3493 | 13 | None | 1 | 3 | Rat | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 474 | 6 | 1 | 6 | 3.3 | CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N | 10.1016/j.bmcl.2013.09.097 | |||
| 76310958 | 105727 | 1 | None | -1 | 2 | Rat | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 340 | 3 | 1 | 6 | 2.2 | CN1CCC(COC(=O)c2cc(Cl)c(N)c3c2OCCO3)CC1 | 10.1016/j.bmcl.2013.09.097 | |||
| CHEMBL3126112 | 105727 | 1 | None | -1 | 2 | Rat | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 340 | 3 | 1 | 6 | 2.2 | CN1CCC(COC(=O)c2cc(Cl)c(N)c3c2OCCO3)CC1 | 10.1016/j.bmcl.2013.09.097 | |||
| CHEMBL5182119 | 105727 | 1 | None | -1 | 2 | Rat | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 340 | 3 | 1 | 6 | 2.2 | CN1CCC(COC(=O)c2cc(Cl)c(N)c3c2OCCO3)CC1 | 10.1016/j.bmcl.2013.09.097 | |||
| 119376 | 1841 | 48 | None | -1 | 26 | Human | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/np0601760 | |||
| 247 | 1841 | 48 | None | -1 | 26 | Human | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/np0601760 | |||
| CHEMBL33884 | 1841 | 48 | None | -1 | 26 | Human | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/np0601760 | |||
| 243 | 3202 | 91 | None | 12 | 34 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.2c00633 | |||
| 3052762 | 3202 | 91 | None | 12 | 34 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.2c00633 | |||
| 3502 | 3202 | 91 | None | 12 | 34 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.2c00633 | |||
| CHEMBL117287 | 3202 | 91 | None | 12 | 34 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.2c00633 | |||
| DB06480 | 3202 | 91 | None | 12 | 34 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.2c00633 | |||
| 121881 | 3490 | 27 | None | 11 | 14 | Human | 10.8 | pKi | = | 10.8 | Binding | ChEMBL | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10.1016/j.bmc.2008.11.045 | |||
| 256 | 3490 | 27 | None | 11 | 14 | Human | 10.8 | pKi | = | 10.8 | Binding | ChEMBL | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10.1016/j.bmc.2008.11.045 | |||
| CHEMBL68131 | 3490 | 27 | None | 11 | 14 | Human | 10.8 | pKi | = | 10.8 | Binding | ChEMBL | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10.1016/j.bmc.2008.11.045 | |||
| 9936969 | 64134 | 0 | None | - | 1 | Human | 10.8 | pKi | = | 10.8 | Binding | ChEMBL | 534 | 9 | 1 | 7 | 2.2 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCN(C3CCCC3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | |||
| CHEMBL180835 | 64134 | 0 | None | - | 1 | Human | 10.8 | pKi | = | 10.8 | Binding | ChEMBL | 534 | 9 | 1 | 7 | 2.2 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCN(C3CCCC3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | |||
| 44390256 | 64339 | 0 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 522 | 10 | 1 | 7 | 2.0 | CCC(C)N1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | |||
| CHEMBL181202 | 64339 | 0 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 522 | 10 | 1 | 7 | 2.0 | CCC(C)N1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | |||
| 9914629 | 123115 | 0 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 519 | 8 | 1 | 6 | 3.3 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCC3(CCCC3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | |||
| CHEMBL361118 | 123115 | 0 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 519 | 8 | 1 | 6 | 3.3 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCC3(CCCC3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | |||
| 9870916 | 64322 | 0 | None | - | 1 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 508 | 10 | 1 | 7 | 1.6 | CCCN1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | |||
| CHEMBL181126 | 64322 | 0 | None | - | 1 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 508 | 10 | 1 | 7 | 1.6 | CCCN1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | |||
| 9892494 | 65468 | 0 | None | - | 1 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 508 | 9 | 1 | 7 | 1.6 | CC(C)N1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | |||
| CHEMBL182999 | 65468 | 0 | None | - | 1 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 508 | 9 | 1 | 7 | 1.6 | CC(C)N1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | |||
| 9873926 | 129656 | 0 | None | - | 1 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 624 | 10 | 1 | 8 | 1.8 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCN(S(=O)(=O)c3ccc(F)cc3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | |||
| CHEMBL367354 | 129656 | 0 | None | - | 1 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 624 | 10 | 1 | 8 | 1.8 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCN(S(=O)(=O)c3ccc(F)cc3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | |||
| 119376 | 1841 | 48 | None | -1 | 26 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.ejmech.2013.03.060 | |||
| 247 | 1841 | 48 | None | -1 | 26 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.ejmech.2013.03.060 | |||
| CHEMBL33884 | 1841 | 48 | None | -1 | 26 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.ejmech.2013.03.060 | |||
| 119376 | 1841 | 48 | None | -1 | 26 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.bmc.2013.09.004 | |||
| 247 | 1841 | 48 | None | -1 | 26 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.bmc.2013.09.004 | |||
| CHEMBL33884 | 1841 | 48 | None | -1 | 26 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.bmc.2013.09.004 | |||
| 71455625 | 82964 | 0 | None | 3388 | 5 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 353 | 5 | 0 | 4 | 4.4 | CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1 | 10.1021/jm300943r | |||
| CHEMBL2181170 | 82964 | 0 | None | 3388 | 5 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 353 | 5 | 0 | 4 | 4.4 | CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1 | 10.1021/jm300943r | |||
| 71455625 | 82964 | 0 | None | 3388 | 5 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 353 | 5 | 0 | 4 | 4.4 | CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1 | 10.1016/j.bmc.2013.08.061 | |||
| CHEMBL2181170 | 82964 | 0 | None | 3388 | 5 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 353 | 5 | 0 | 4 | 4.4 | CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1 | 10.1016/j.bmc.2013.08.061 | |||
| 71455625 | 82964 | 0 | None | 3388 | 5 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 353 | 5 | 0 | 4 | 4.4 | CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1 | 10.1021/jm300943r | |||
| CHEMBL2181170 | 82964 | 0 | None | 3388 | 5 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 353 | 5 | 0 | 4 | 4.4 | CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1 | 10.1021/jm300943r | |||
| 53325605 | 56447 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 489 | 9 | 1 | 6 | 4.4 | O=C(CCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1)OCc1ccccc1 | 10.1016/j.bmc.2010.10.011 | |||
| CHEMBL1632165 | 56447 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 489 | 9 | 1 | 6 | 4.4 | O=C(CCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1)OCc1ccccc1 | 10.1016/j.bmc.2010.10.011 | |||
| 46935636 | 102572 | 0 | None | 31622 | 2 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.9 | O=C(O)c1ccccc1-c1ccc(CN2CCC(COC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2013.09.004 | |||
| CHEMBL2440460 | 102572 | 0 | None | 31622 | 2 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.9 | O=C(O)c1ccccc1-c1ccc(CN2CCC(COC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2013.09.004 | |||
| CHEMBL3040772 | 102572 | 0 | None | 31622 | 2 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.9 | O=C(O)c1ccccc1-c1ccc(CN2CCC(COC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2013.09.004 | |||
| 118712571 | 114233 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 538 | 9 | 2 | 6 | 4.5 | CC(C)CS(=O)(=O)Nc1ccc(CN2CCC(CNC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmcl.2014.06.083 | |||
| CHEMBL3329805 | 114233 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 538 | 9 | 2 | 6 | 4.5 | CC(C)CS(=O)(=O)Nc1ccc(CN2CCC(CNC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmcl.2014.06.083 | |||
| 9807895 | 63950 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 560 | 9 | 1 | 7 | 2.6 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCN(c3ccc(F)cc3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | |||
| CHEMBL180680 | 63950 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 560 | 9 | 1 | 7 | 2.6 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCN(c3ccc(F)cc3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | |||
| 9870390 | 165792 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 494 | 9 | 1 | 7 | 1.3 | CCN1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | |||
| CHEMBL424790 | 165792 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 494 | 9 | 1 | 7 | 1.3 | CCN1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | |||
| 177336 | 3120 | 50 | None | 1412 | 2 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2010.10.011 | |||
| 225 | 3120 | 50 | None | 1412 | 2 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2010.10.011 | |||
| CHEMBL356359 | 3120 | 50 | None | 1412 | 2 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2010.10.011 | |||
| DB04873 | 3120 | 50 | None | 1412 | 2 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2010.10.011 | |||
| 50898776 | 56445 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 483 | 9 | 1 | 6 | 4.8 | CC(C)(C)OC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | |||
| CHEMBL1632163 | 56445 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 483 | 9 | 1 | 6 | 4.8 | CC(C)(C)OC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | |||
| 46935596 | 92876 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 537 | 7 | 1 | 6 | 5.5 | COC(=O)c1ccccc1-c1ccc(CN2CCC(CNC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2013.09.004 | |||
| CHEMBL2440457 | 92876 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 537 | 7 | 1 | 6 | 5.5 | COC(=O)c1ccccc1-c1ccc(CN2CCC(CNC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2013.09.004 | |||
| 9892465 | 63789 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 507 | 10 | 1 | 6 | 3.1 | CCCC1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | |||
| CHEMBL180201 | 63789 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 507 | 10 | 1 | 6 | 3.1 | CCCC1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | |||
| 50898699 | 56450 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 541 | 11 | 1 | 8 | 4.5 | CC(C)(C)C(=O)OCOC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | |||
| CHEMBL1632169 | 56450 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 541 | 11 | 1 | 8 | 4.5 | CC(C)(C)C(=O)OCOC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | |||
| 72545050 | 105725 | 0 | None | - | 1 | Rat | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 386 | 6 | 1 | 6 | 2.9 | Nc1c(Cl)cc(C(=O)OCC2CCN(CCCF)CC2)c2c1OCCO2 | 10.1016/j.bmcl.2013.09.097 | |||
| CHEMBL3126108 | 105725 | 0 | None | - | 1 | Rat | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 386 | 6 | 1 | 6 | 2.9 | Nc1c(Cl)cc(C(=O)OCC2CCN(CCCF)CC2)c2c1OCCO2 | 10.1016/j.bmcl.2013.09.097 | |||
| 119376 | 1841 | 48 | None | -1 | 26 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | |||
| 247 | 1841 | 48 | None | -1 | 26 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | |||
| CHEMBL33884 | 1841 | 48 | None | -1 | 26 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | |||
| 9954930 | 84585 | 0 | None | 398 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 404 | 7 | 1 | 4 | 4.3 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccccc3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| CHEMBL2177130 | 84585 | 0 | None | 398 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 404 | 7 | 1 | 4 | 4.3 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccccc3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| CHEMBL2220969 | 84585 | 0 | None | 398 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 404 | 7 | 1 | 4 | 4.3 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccccc3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| 91754444 | 114242 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 388 | 6 | 2 | 7 | 1.6 | O=C(OCC1CCN(CC(O)CO)CC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmcl.2014.06.083 | |||
| CHEMBL3329814 | 114242 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 388 | 6 | 2 | 7 | 1.6 | O=C(OCC1CCN(CC(O)CO)CC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmcl.2014.06.083 | |||
| 21268036 | 122734 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 599 | 10 | 1 | 8 | 0.6 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCN(S(=O)(=O)N3CCCC3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | |||
| CHEMBL360449 | 122734 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 599 | 10 | 1 | 8 | 0.6 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCN(S(=O)(=O)N3CCCC3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | |||
| 90667897 | 109530 | 0 | None | - | 1 | Rat | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 364 | 6 | 2 | 3 | 4.0 | CCCCN1CCC(CNC(=S)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1039/C0MD00258E | |||
| CHEMBL3221572 | 109530 | 0 | None | - | 1 | Rat | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 364 | 6 | 2 | 3 | 4.0 | CCCCN1CCC(CNC(=S)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1039/C0MD00258E | |||
| 119376 | 1841 | 48 | None | -1 | 26 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | |||
| 247 | 1841 | 48 | None | -1 | 26 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | |||
| CHEMBL33884 | 1841 | 48 | None | -1 | 26 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | |||
| 11153975 | 84566 | 7 | None | 1000 | 2 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 405 | 7 | 1 | 5 | 3.7 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccccn3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| CHEMBL2179697 | 84566 | 7 | None | 1000 | 2 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 405 | 7 | 1 | 5 | 3.7 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccccn3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| CHEMBL2220892 | 84566 | 7 | None | 1000 | 2 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 405 | 7 | 1 | 5 | 3.7 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccccn3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| 177336 | 3120 | 50 | None | 1412 | 2 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.ejmech.2013.03.060 | |||
| 225 | 3120 | 50 | None | 1412 | 2 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.ejmech.2013.03.060 | |||
| CHEMBL356359 | 3120 | 50 | None | 1412 | 2 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.ejmech.2013.03.060 | |||
| DB04873 | 3120 | 50 | None | 1412 | 2 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.ejmech.2013.03.060 | |||
| 177336 | 3120 | 50 | None | 1412 | 2 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2013.09.004 | |||
| 225 | 3120 | 50 | None | 1412 | 2 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2013.09.004 | |||
| CHEMBL356359 | 3120 | 50 | None | 1412 | 2 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2013.09.004 | |||
| DB04873 | 3120 | 50 | None | 1412 | 2 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2013.09.004 | |||
| 21268033 | 64128 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 560 | 9 | 1 | 8 | 1.7 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCN(C(=O)c3ccco3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | |||
| CHEMBL180830 | 64128 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 560 | 9 | 1 | 8 | 1.7 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCN(C(=O)c3ccco3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | |||
| 15485936 | 122607 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 572 | 11 | 1 | 8 | 1.0 | CCCS(=O)(=O)N1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | |||
| CHEMBL360245 | 122607 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 572 | 11 | 1 | 8 | 1.0 | CCCS(=O)(=O)N1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | |||
| 53319410 | 56439 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 427 | 8 | 1 | 6 | 3.2 | CCOC(=O)CCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | |||
| CHEMBL1632157 | 56439 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 427 | 8 | 1 | 6 | 3.2 | CCOC(=O)CCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | |||
| 50898777 | 56440 | 0 | None | 2951 | 8 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 441 | 9 | 1 | 6 | 3.6 | COC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | |||
| CHEMBL1632158 | 56440 | 0 | None | 2951 | 8 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 441 | 9 | 1 | 6 | 3.6 | COC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | |||
| 10476858 | 112365 | 0 | None | - | 1 | Rat | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 413 | 7 | 3 | 5 | 1.2 | CS(=O)(=O)NCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL329487 | 112365 | 0 | None | - | 1 | Rat | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 413 | 7 | 3 | 5 | 1.2 | CS(=O)(=O)NCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 10476858 | 112365 | 0 | None | - | 1 | Rat | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 413 | 7 | 3 | 5 | 1.2 | CS(=O)(=O)NCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| CHEMBL329487 | 112365 | 0 | None | - | 1 | Rat | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 413 | 7 | 3 | 5 | 1.2 | CS(=O)(=O)NCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| 72698087 | 103988 | 0 | None | 2089 | 2 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 407 | 5 | 0 | 4 | 5.0 | Fc1cccc2c1nc(OCC1CCN(CCC(F)(F)F)CC1)c1cccnc12 | 10.1016/j.bmc.2013.08.061 | |||
| CHEMBL3093186 | 103988 | 0 | None | 2089 | 2 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 407 | 5 | 0 | 4 | 5.0 | Fc1cccc2c1nc(OCC1CCN(CCC(F)(F)F)CC1)c1cccnc12 | 10.1016/j.bmc.2013.08.061 | |||
| 10476858 | 112365 | 0 | None | - | 1 | Rat | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 413 | 7 | 3 | 5 | 1.2 | CS(=O)(=O)NCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL329487 | 112365 | 0 | None | - | 1 | Rat | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 413 | 7 | 3 | 5 | 1.2 | CS(=O)(=O)NCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 46935743 | 90821 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 490 | 7 | 1 | 6 | 4.9 | CC(C)(C(=O)O)c1ccc(CN2CCC(COC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.ejmech.2013.03.060 | |||
| CHEMBL2391994 | 90821 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 490 | 7 | 1 | 6 | 4.9 | CC(C)(C(=O)O)c1ccc(CN2CCC(COC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.ejmech.2013.03.060 | |||
| 21268037 | 62596 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 493 | 8 | 1 | 6 | 2.7 | CC1(C)CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | |||
| CHEMBL178285 | 62596 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 493 | 8 | 1 | 6 | 2.7 | CC1(C)CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | |||
| 21268031 | 62999 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 508 | 8 | 1 | 7 | 0.8 | CC(=O)N1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | |||
| CHEMBL178669 | 62999 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 508 | 8 | 1 | 7 | 0.8 | CC(=O)N1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | |||
| 44390214 | 63466 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 572 | 10 | 1 | 8 | 1.0 | CC(C)S(=O)(=O)N1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | |||
| CHEMBL179833 | 63466 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 572 | 10 | 1 | 8 | 1.0 | CC(C)S(=O)(=O)N1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | |||
| 9952994 | 106970 | 0 | None | - | 1 | Rat | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 366 | 6 | 1 | 5 | 3.5 | CCCCN1CCC(COC(=O)c2cc(Cl)c(N)c3c2OCC3)CC1 | 10.1016/0960-894X(96)00002-9 | |||
| CHEMBL315071 | 106970 | 0 | None | - | 1 | Rat | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 366 | 6 | 1 | 5 | 3.5 | CCCCN1CCC(COC(=O)c2cc(Cl)c(N)c3c2OCC3)CC1 | 10.1016/0960-894X(96)00002-9 | |||
| 50898775 | 56448 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 517 | 11 | 1 | 6 | 5.2 | O=C(CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1)OCc1ccccc1 | 10.1016/j.bmc.2010.10.011 | |||
| CHEMBL1632167 | 56448 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 517 | 11 | 1 | 6 | 5.2 | O=C(CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1)OCc1ccccc1 | 10.1016/j.bmc.2010.10.011 | |||
| 119376 | 1841 | 48 | None | -2 | 26 | Rat | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm960853v | |||
| 247 | 1841 | 48 | None | -2 | 26 | Rat | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm960853v | |||
| CHEMBL33884 | 1841 | 48 | None | -2 | 26 | Rat | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm960853v | |||
| 119376 | 1841 | 48 | None | -2 | 26 | Rat | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm960320m | |||
| 247 | 1841 | 48 | None | -2 | 26 | Rat | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm960320m | |||
| CHEMBL33884 | 1841 | 48 | None | -2 | 26 | Rat | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm960320m | |||
| 90667896 | 109529 | 0 | None | - | 1 | Rat | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 330 | 6 | 2 | 3 | 3.3 | CCCCN1CCC(CNC(=S)c2cccc3[nH]cnc23)CC1 | 10.1039/C0MD00258E | |||
| CHEMBL3221571 | 109529 | 0 | None | - | 1 | Rat | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 330 | 6 | 2 | 3 | 3.3 | CCCCN1CCC(CNC(=S)c2cccc3[nH]cnc23)CC1 | 10.1039/C0MD00258E | |||
| 53354764 | 3064 | 34 | None | 1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | |||
| 9059 | 3064 | 34 | None | 1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | |||
| CHEMBL2152922 | 3064 | 34 | None | 1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | |||
| DB12675 | 3064 | 34 | None | 1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | |||
| 119376 | 1841 | 48 | None | -1 | 26 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.bmc.2008.11.045 | |||
| 247 | 1841 | 48 | None | -1 | 26 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.bmc.2008.11.045 | |||
| CHEMBL33884 | 1841 | 48 | None | -1 | 26 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.bmc.2008.11.045 | |||
| 177336 | 3120 | 50 | None | 1412 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1021/jm300573d | |||
| 225 | 3120 | 50 | None | 1412 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1021/jm300573d | |||
| CHEMBL356359 | 3120 | 50 | None | 1412 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1021/jm300573d | |||
| DB04873 | 3120 | 50 | None | 1412 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1021/jm300573d | |||
| 21252894 | 84596 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 410 | 7 | 1 | 4 | 5.0 | CC(C)n1nc(C(=O)NCC2CCN(CCC3CCCCC3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| CHEMBL2179699 | 84596 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 410 | 7 | 1 | 4 | 5.0 | CC(C)n1nc(C(=O)NCC2CCN(CCC3CCCCC3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| CHEMBL2221066 | 84596 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 410 | 7 | 1 | 4 | 5.0 | CC(C)n1nc(C(=O)NCC2CCN(CCC3CCCCC3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| 11317280 | 63978 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 466 | 8 | 2 | 7 | 0.5 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCNCC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | |||
| CHEMBL180697 | 63978 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 466 | 8 | 2 | 7 | 0.5 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCNCC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | |||
| 44390243 | 64484 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 557 | 10 | 1 | 8 | 1.8 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCN(Cc3cccnc3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | |||
| CHEMBL181415 | 64484 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 557 | 10 | 1 | 8 | 1.8 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCN(Cc3cccnc3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | |||
| 53317702 | 56441 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 497 | 13 | 1 | 6 | 5.2 | COC(=O)CCCCCCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | |||
| CHEMBL1632159 | 56441 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 497 | 13 | 1 | 6 | 5.2 | COC(=O)CCCCCCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | |||
| 9823412 | 84610 | 0 | None | 398 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 419 | 7 | 2 | 5 | 3.9 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc(N)cc3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| CHEMBL2221193 | 84610 | 0 | None | 398 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 419 | 7 | 2 | 5 | 3.9 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc(N)cc3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| CHEMBL3216126 | 84610 | 0 | None | 398 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 419 | 7 | 2 | 5 | 3.9 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc(N)cc3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| 118712569 | 114231 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 496 | 7 | 2 | 6 | 3.4 | CS(=O)(=O)Nc1ccc(CN2CCC(CNC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmcl.2014.06.083 | |||
| CHEMBL3329803 | 114231 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 496 | 7 | 2 | 6 | 3.4 | CS(=O)(=O)Nc1ccc(CN2CCC(CNC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmcl.2014.06.083 | |||
| 118712572 | 114234 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 564 | 8 | 2 | 6 | 5.1 | O=C(NCC1CCN(Cc2ccc(NS(=O)(=O)C3CCCCC3)cc2)CC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmcl.2014.06.083 | |||
| CHEMBL3329806 | 114234 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 564 | 8 | 2 | 6 | 5.1 | O=C(NCC1CCN(Cc2ccc(NS(=O)(=O)C3CCCCC3)cc2)CC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmcl.2014.06.083 | |||
| 118712573 | 114235 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 459 | 7 | 2 | 6 | 2.5 | CS(=O)(=O)Nc1ccc(CN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)cc1 | 10.1016/j.bmcl.2014.06.083 | |||
| CHEMBL3329807 | 114235 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 459 | 7 | 2 | 6 | 2.5 | CS(=O)(=O)Nc1ccc(CN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)cc1 | 10.1016/j.bmcl.2014.06.083 | |||
| 118712575 | 114237 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 501 | 9 | 2 | 6 | 3.5 | CC(C)CS(=O)(=O)Nc1ccc(CN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)cc1 | 10.1016/j.bmcl.2014.06.083 | |||
| CHEMBL3329809 | 114237 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 501 | 9 | 2 | 6 | 3.5 | CC(C)CS(=O)(=O)Nc1ccc(CN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)cc1 | 10.1016/j.bmcl.2014.06.083 | |||
| 44390192 | 64771 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 465 | 8 | 1 | 6 | 2.1 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCCCC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | |||
| CHEMBL181928 | 64771 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 465 | 8 | 1 | 6 | 2.1 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCCCC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | |||
| 72698088 | 103989 | 0 | None | 954 | 4 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 421 | 6 | 0 | 4 | 5.4 | Fc1cccc2c1nc(OCC1CCN(CCCC(F)(F)F)CC1)c1cccnc12 | 10.1016/j.bmc.2013.08.061 | |||
| CHEMBL3093187 | 103989 | 0 | None | 954 | 4 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 421 | 6 | 0 | 4 | 5.4 | Fc1cccc2c1nc(OCC1CCN(CCCC(F)(F)F)CC1)c1cccnc12 | 10.1016/j.bmc.2013.08.061 | |||
| 72545049 | 105726 | 0 | None | - | 1 | Rat | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 372 | 5 | 1 | 6 | 2.5 | Nc1c(Cl)cc(C(=O)OCC2CCN(CCF)CC2)c2c1OCCO2 | 10.1016/j.bmcl.2013.09.097 | |||
| CHEMBL3126109 | 105726 | 0 | None | - | 1 | Rat | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 372 | 5 | 1 | 6 | 2.5 | Nc1c(Cl)cc(C(=O)OCC2CCN(CCF)CC2)c2c1OCCO2 | 10.1016/j.bmcl.2013.09.097 | |||
| 71459269 | 82960 | 0 | None | 660 | 7 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 555 | 7 | 0 | 4 | 6.3 | Fc1cccc2c1nc(OCC1CCN(CCCc3ccc(I)cc3)CC1)c1cccnc12 | 10.1021/jm300943r | |||
| CHEMBL2181166 | 82960 | 0 | None | 660 | 7 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 555 | 7 | 0 | 4 | 6.3 | Fc1cccc2c1nc(OCC1CCN(CCCc3ccc(I)cc3)CC1)c1cccnc12 | 10.1021/jm300943r | |||
| 53320711 | 56444 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 455 | 7 | 1 | 6 | 4.0 | CC(C)(C)OC(=O)CCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | |||
| CHEMBL1632162 | 56444 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 455 | 7 | 1 | 6 | 4.0 | CC(C)(C)OC(=O)CCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | |||
| 17984294 | 84608 | 0 | None | 39 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 420 | 7 | 2 | 5 | 4.0 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc(O)cc3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| CHEMBL2179704 | 84608 | 0 | None | 39 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 420 | 7 | 2 | 5 | 4.0 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc(O)cc3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| CHEMBL2221162 | 84608 | 0 | None | 39 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 420 | 7 | 2 | 5 | 4.0 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc(O)cc3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| 119376 | 1841 | 48 | None | -1 | 26 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.bmcl.2014.06.083 | |||
| 247 | 1841 | 48 | None | -1 | 26 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.bmcl.2014.06.083 | |||
| CHEMBL33884 | 1841 | 48 | None | -1 | 26 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.bmcl.2014.06.083 | |||
| 118712574 | 114236 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 501 | 10 | 2 | 6 | 3.6 | CCCCS(=O)(=O)Nc1ccc(CN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)cc1 | 10.1016/j.bmcl.2014.06.083 | |||
| CHEMBL3329808 | 114236 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 501 | 10 | 2 | 6 | 3.6 | CCCCS(=O)(=O)Nc1ccc(CN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)cc1 | 10.1016/j.bmcl.2014.06.083 | |||
| 177336 | 3120 | 50 | None | 1412 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmcl.2005.01.039 | |||
| 225 | 3120 | 50 | None | 1412 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmcl.2005.01.039 | |||
| CHEMBL356359 | 3120 | 50 | None | 1412 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmcl.2005.01.039 | |||
| DB04873 | 3120 | 50 | None | 1412 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmcl.2005.01.039 | |||
| 9869791 | 63926 | 20 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 480 | 8 | 1 | 7 | 0.9 | CN1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | |||
| CHEMBL180632 | 63926 | 20 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 480 | 8 | 1 | 7 | 0.9 | CN1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | |||
| 44390227 | 122812 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 543 | 9 | 1 | 8 | 1.8 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCN(c3ccccn3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | |||
| CHEMBL360531 | 122812 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 543 | 9 | 1 | 8 | 1.8 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCN(c3ccccn3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | |||
| 10831066 | 188836 | 6 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(Cl)cc1C(=O)OCCN1C[C@@H](C)C[C@@H](C)C1 | 10.1021/jm960853v | |||
| CHEMBL50660 | 188836 | 6 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(Cl)cc1C(=O)OCCN1C[C@@H](C)C[C@@H](C)C1 | 10.1021/jm960853v | |||
| 249 | 2565 | 4 | None | -1 | 2 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10.1021/jm960320m | |||
| 9905972 | 2565 | 4 | None | -1 | 2 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10.1021/jm960320m | |||
| CHEMBL155917 | 2565 | 4 | None | -1 | 2 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10.1021/jm960320m | |||
| 71457409 | 82962 | 0 | None | 1318 | 5 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 461 | 5 | 0 | 4 | 4.9 | CCCN1CCC(COc2nc3c(I)cccc3c3ncccc23)CC1 | 10.1021/jm300943r | |||
| CHEMBL2181168 | 82962 | 0 | None | 1318 | 5 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 461 | 5 | 0 | 4 | 4.9 | CCCN1CCC(COc2nc3c(I)cccc3c3ncccc23)CC1 | 10.1021/jm300943r | |||
| 71450132 | 82677 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 358 | 8 | 0 | 5 | 4.7 | CCCCN1CCC(COc2noc3cccc(OC4CCC4)c23)CC1 | 10.1021/jm300953p | |||
| CHEMBL2179584 | 82677 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 358 | 8 | 0 | 5 | 4.7 | CCCCN1CCC(COc2noc3cccc(OC4CCC4)c23)CC1 | 10.1021/jm300953p | |||
| 10472977 | 96554 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 348 | 5 | 2 | 3 | 3.3 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL262950 | 96554 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 348 | 5 | 2 | 3 | 3.3 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 10472977 | 96554 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 348 | 5 | 2 | 3 | 3.3 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| CHEMBL262950 | 96554 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 348 | 5 | 2 | 3 | 3.3 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| 71462651 | 82680 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 360 | 9 | 0 | 5 | 4.8 | CCCCN1CCC(COc2noc3cccc(OCC(C)C)c23)CC1 | 10.1021/jm300953p | |||
| CHEMBL2179587 | 82680 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 360 | 9 | 0 | 5 | 4.8 | CCCCN1CCC(COc2noc3cccc(OCC(C)C)c23)CC1 | 10.1021/jm300953p | |||
| 10472977 | 96554 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 348 | 5 | 2 | 3 | 3.3 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL262950 | 96554 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 348 | 5 | 2 | 3 | 3.3 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 76310958 | 105727 | 1 | None | 1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 340 | 3 | 1 | 6 | 2.2 | CN1CCC(COC(=O)c2cc(Cl)c(N)c3c2OCCO3)CC1 | 10.1021/acs.jmedchem.2c00633 | |||
| CHEMBL3126112 | 105727 | 1 | None | 1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 340 | 3 | 1 | 6 | 2.2 | CN1CCC(COC(=O)c2cc(Cl)c(N)c3c2OCCO3)CC1 | 10.1021/acs.jmedchem.2c00633 | |||
| CHEMBL5182119 | 105727 | 1 | None | 1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 340 | 3 | 1 | 6 | 2.2 | CN1CCC(COC(=O)c2cc(Cl)c(N)c3c2OCCO3)CC1 | 10.1021/acs.jmedchem.2c00633 | |||
| 53354764 | 3064 | 34 | None | -1 | 2 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | |||
| 9059 | 3064 | 34 | None | -1 | 2 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | |||
| CHEMBL2152922 | 3064 | 34 | None | -1 | 2 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | |||
| DB12675 | 3064 | 34 | None | -1 | 2 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | |||
| 71712326 | 91386 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 554 | 9 | 3 | 7 | 1.7 | CC(C)c1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cc(Cl)cc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | |||
| CHEMBL2402896 | 91386 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 554 | 9 | 3 | 7 | 1.7 | CC(C)c1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cc(Cl)cc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | |||
| 21252889 | 84576 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 421 | 8 | 2 | 6 | 1.6 | CC(C)n1nc(C(=O)NCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| CHEMBL2179702 | 84576 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 421 | 8 | 2 | 6 | 1.6 | CC(C)n1nc(C(=O)NCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| CHEMBL2220908 | 84576 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 421 | 8 | 2 | 6 | 1.6 | CC(C)n1nc(C(=O)NCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| 118712580 | 114241 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 476 | 7 | 1 | 6 | 4.7 | CC(C(=O)O)c1ccc(CN2CCC(COC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmcl.2014.06.083 | |||
| CHEMBL3329813 | 114241 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 476 | 7 | 1 | 6 | 4.7 | CC(C(=O)O)c1ccc(CN2CCC(COC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmcl.2014.06.083 | |||
| 44390250 | 63460 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 544 | 9 | 1 | 8 | 0.2 | CS(=O)(=O)N1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | |||
| CHEMBL179799 | 63460 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 544 | 9 | 1 | 8 | 0.2 | CS(=O)(=O)N1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | |||
| 10089141 | 207572 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 348 | 6 | 2 | 3 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| CHEMBL94880 | 207572 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 348 | 6 | 2 | 3 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| 10089141 | 207572 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 348 | 6 | 2 | 3 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1039/C0MD00258E | |||
| CHEMBL94880 | 207572 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 348 | 6 | 2 | 3 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1039/C0MD00258E | |||
| 53354764 | 3064 | 34 | None | 1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | |||
| 9059 | 3064 | 34 | None | 1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | |||
| CHEMBL2152922 | 3064 | 34 | None | 1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | |||
| DB12675 | 3064 | 34 | None | 1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | |||
| 10089141 | 207572 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 348 | 6 | 2 | 3 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL94880 | 207572 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 348 | 6 | 2 | 3 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 10089141 | 207572 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 348 | 6 | 2 | 3 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL94880 | 207572 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 348 | 6 | 2 | 3 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 119376 | 1841 | 48 | None | -1 | 26 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | |||
| 247 | 1841 | 48 | None | -1 | 26 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | |||
| CHEMBL33884 | 1841 | 48 | None | -1 | 26 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | |||
| 53319411 | 56442 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 525 | 15 | 1 | 6 | 5.9 | COC(=O)CCCCCCCCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | |||
| CHEMBL1632160 | 56442 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 525 | 15 | 1 | 6 | 5.9 | COC(=O)CCCCCCCCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | |||
| 53324684 | 56449 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 4.8 | CC(C)(C)C(=O)OCOC(=O)c1ccc(CN2CCC(CNC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2010.10.011 | |||
| CHEMBL1632168 | 56449 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 4.8 | CC(C)(C)C(=O)OCOC(=O)c1ccc(CN2CCC(CNC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2010.10.011 | |||
| 53354764 | 3064 | 34 | None | 1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | |||
| 9059 | 3064 | 34 | None | 1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | |||
| CHEMBL2152922 | 3064 | 34 | None | 1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | |||
| DB12675 | 3064 | 34 | None | 1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | |||
| 53357029 | 82682 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 418 | 8 | 1 | 7 | 3.5 | CC(C)COc1cccc2onc(OCC3CCN(CC4(O)CCOCC4)CC3)c12 | 10.1021/jm300953p | |||
| CHEMBL2179589 | 82682 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 418 | 8 | 1 | 7 | 3.5 | CC(C)COc1cccc2onc(OCC3CCN(CC4(O)CCOCC4)CC3)c12 | 10.1021/jm300953p | |||
| 11961293 | 3769 | 19 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.bmcl.2013.05.018 | |||
| 8426 | 3769 | 19 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.bmcl.2013.05.018 | |||
| CHEMBL2402904 | 3769 | 19 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.bmcl.2013.05.018 | |||
| DB12725 | 3769 | 19 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.bmcl.2013.05.018 | |||
| 21252892 | 84574 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 413 | 7 | 1 | 6 | 2.4 | CC(C)n1nc(C(=O)NCC2CCN(CCN3CCOCC3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| CHEMBL2220906 | 84574 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 413 | 7 | 1 | 6 | 2.4 | CC(C)n1nc(C(=O)NCC2CCN(CCN3CCOCC3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| CHEMBL3215681 | 84574 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 413 | 7 | 1 | 6 | 2.4 | CC(C)n1nc(C(=O)NCC2CCN(CCN3CCOCC3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| 177336 | 3120 | 50 | None | 1412 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmcl.2014.06.083 | |||
| 225 | 3120 | 50 | None | 1412 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmcl.2014.06.083 | |||
| CHEMBL356359 | 3120 | 50 | None | 1412 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmcl.2014.06.083 | |||
| DB04873 | 3120 | 50 | None | 1412 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmcl.2014.06.083 | |||
| 9912434 | 123853 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 467 | 8 | 1 | 7 | 1.0 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCOCC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | |||
| CHEMBL362582 | 123853 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 467 | 8 | 1 | 7 | 1.0 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCOCC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | |||
| 119376 | 1841 | 48 | None | -1 | 26 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | |||
| 247 | 1841 | 48 | None | -1 | 26 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | |||
| CHEMBL33884 | 1841 | 48 | None | -1 | 26 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | |||
| 53354764 | 3064 | 34 | None | 1 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | |||
| 9059 | 3064 | 34 | None | 1 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | |||
| CHEMBL2152922 | 3064 | 34 | None | 1 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | |||
| DB12675 | 3064 | 34 | None | 1 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | |||
| 119376 | 1841 | 48 | None | -1 | 26 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm070552t | |||
| 247 | 1841 | 48 | None | -1 | 26 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm070552t | |||
| CHEMBL33884 | 1841 | 48 | None | -1 | 26 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm070552t | |||
| 53357011 | 82673 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 446 | 7 | 2 | 8 | 2.8 | O[C@@H]1CC[C@@H](Oc2cccc3onc(OCC4CCN(CC5(O)CCOCC5)CC4)c23)C1 | 10.1021/jm300953p | |||
| CHEMBL2179580 | 82673 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 446 | 7 | 2 | 8 | 2.8 | O[C@@H]1CC[C@@H](Oc2cccc3onc(OCC4CCN(CC5(O)CCOCC5)CC4)c23)C1 | 10.1021/jm300953p | |||
| 177336 | 3120 | 50 | None | 1412 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2008.11.045 | |||
| 225 | 3120 | 50 | None | 1412 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2008.11.045 | |||
| CHEMBL356359 | 3120 | 50 | None | 1412 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2008.11.045 | |||
| DB04873 | 3120 | 50 | None | 1412 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2008.11.045 | |||
| 71714540 | 91380 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 506 | 9 | 3 | 7 | 0.5 | CCc1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | |||
| CHEMBL2402890 | 91380 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 506 | 9 | 3 | 7 | 0.5 | CCc1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | |||
| 71714541 | 91381 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 520 | 9 | 3 | 7 | 1.1 | CC(C)c1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | |||
| CHEMBL2402891 | 91381 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 520 | 9 | 3 | 7 | 1.1 | CC(C)c1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | |||
| 71714542 | 91382 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 518 | 9 | 3 | 7 | 0.8 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(CNC(=O)c3cccc4[nH]c(C5CC5)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | |||
| CHEMBL2402892 | 91382 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 518 | 9 | 3 | 7 | 0.8 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(CNC(=O)c3cccc4[nH]c(C5CC5)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | |||
| 66810955 | 91393 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 475 | 7 | 2 | 5 | 2.8 | CC(C)c1nc2c(C(=O)NCC3CCN(CC4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | |||
| CHEMBL2402903 | 91393 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 475 | 7 | 2 | 5 | 2.8 | CC(C)c1nc2c(C(=O)NCC3CCN(CC4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | |||
| 177336 | 3120 | 50 | None | 1412 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1021/jm00024a002 | |||
| 225 | 3120 | 50 | None | 1412 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1021/jm00024a002 | |||
| CHEMBL356359 | 3120 | 50 | None | 1412 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1021/jm00024a002 | |||
| DB04873 | 3120 | 50 | None | 1412 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1021/jm00024a002 | |||
| 71457299 | 84607 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 385 | 7 | 2 | 5 | 2.2 | CNC(=O)CCN1CCC(CNC(=O)c2nn(C(C)C)c3ccccc23)CC1 | 10.1021/jm300573d | |||
| CHEMBL2179703 | 84607 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 385 | 7 | 2 | 5 | 2.2 | CNC(=O)CCN1CCC(CNC(=O)c2nn(C(C)C)c3ccccc23)CC1 | 10.1021/jm300573d | |||
| CHEMBL2221161 | 84607 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 385 | 7 | 2 | 5 | 2.2 | CNC(=O)CCN1CCC(CNC(=O)c2nn(C(C)C)c3ccccc23)CC1 | 10.1021/jm300573d | |||
| 119376 | 1841 | 48 | None | -1 | 26 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | |||
| 247 | 1841 | 48 | None | -1 | 26 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | |||
| CHEMBL33884 | 1841 | 48 | None | -1 | 26 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | |||
| 44327645 | 208117 | 0 | None | - | 1 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 362 | 7 | 2 | 3 | 3.8 | CCCCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL97955 | 208117 | 0 | None | - | 1 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 362 | 7 | 2 | 3 | 3.8 | CCCCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 44327645 | 208117 | 0 | None | - | 1 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 362 | 7 | 2 | 3 | 3.8 | CCCCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| CHEMBL97955 | 208117 | 0 | None | - | 1 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 362 | 7 | 2 | 3 | 3.8 | CCCCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| 44327645 | 208117 | 0 | None | - | 1 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 362 | 7 | 2 | 3 | 3.8 | CCCCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL97955 | 208117 | 0 | None | - | 1 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 362 | 7 | 2 | 3 | 3.8 | CCCCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 21252899 | 84587 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 390 | 6 | 1 | 4 | 4.3 | CC(C)n1nc(C(=O)NCC2CCN(Cc3ccccc3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| CHEMBL2179696 | 84587 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 390 | 6 | 1 | 4 | 4.3 | CC(C)n1nc(C(=O)NCC2CCN(Cc3ccccc3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| CHEMBL2220973 | 84587 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 390 | 6 | 1 | 4 | 4.3 | CC(C)n1nc(C(=O)NCC2CCN(Cc3ccccc3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| 72697441 | 92877 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 523 | 7 | 2 | 5 | 5.4 | O=C(O)c1ccccc1-c1ccc(CN2CCC(CNC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2013.09.004 | |||
| CHEMBL2440458 | 92877 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 523 | 7 | 2 | 5 | 5.4 | O=C(O)c1ccccc1-c1ccc(CN2CCC(CNC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2013.09.004 | |||
| 11014701 | 207629 | 0 | None | - | 1 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 392 | 6 | 2 | 3 | 3.6 | CCCCN1CCC(CNC(=O)c2cc(Br)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| CHEMBL95178 | 207629 | 0 | None | - | 1 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 392 | 6 | 2 | 3 | 3.6 | CCCCN1CCC(CNC(=O)c2cc(Br)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| 11014701 | 207629 | 0 | None | - | 1 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 392 | 6 | 2 | 3 | 3.6 | CCCCN1CCC(CNC(=O)c2cc(Br)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL95178 | 207629 | 0 | None | - | 1 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 392 | 6 | 2 | 3 | 3.6 | CCCCN1CCC(CNC(=O)c2cc(Br)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 11014701 | 207629 | 0 | None | - | 1 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 392 | 6 | 2 | 3 | 3.6 | CCCCN1CCC(CNC(=O)c2cc(Br)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL95178 | 207629 | 0 | None | - | 1 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 392 | 6 | 2 | 3 | 3.6 | CCCCN1CCC(CNC(=O)c2cc(Br)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 119376 | 1841 | 48 | None | -1 | 26 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm070552t | |||
| 247 | 1841 | 48 | None | -1 | 26 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm070552t | |||
| CHEMBL33884 | 1841 | 48 | None | -1 | 26 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm070552t | |||
| 71451951 | 82678 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 372 | 8 | 0 | 5 | 5.0 | CCCCN1CCC(COc2noc3cccc(OC4CCCC4)c23)CC1 | 10.1021/jm300953p | |||
| CHEMBL2179585 | 82678 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 372 | 8 | 0 | 5 | 5.0 | CCCCN1CCC(COc2noc3cccc(OC4CCCC4)c23)CC1 | 10.1021/jm300953p | |||
| 53322003 | 56443 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 427 | 5 | 1 | 6 | 3.2 | CC(C)(C)OC(=O)CN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | |||
| CHEMBL1632161 | 56443 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 427 | 5 | 1 | 6 | 3.2 | CC(C)(C)OC(=O)CN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | |||
| 71712327 | 91387 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 490 | 8 | 2 | 6 | 1.7 | CC(C)c1nc2c(C(=O)NCC3CCN(CCN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | |||
| CHEMBL2402897 | 91387 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 490 | 8 | 2 | 6 | 1.7 | CC(C)c1nc2c(C(=O)NCC3CCN(CCN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | |||
| 9886435 | 92873 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 385 | 6 | 2 | 5 | 2.6 | CC(O)CCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2013.09.004 | |||
| CHEMBL2440453 | 92873 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 385 | 6 | 2 | 5 | 2.6 | CC(O)CCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2013.09.004 | |||
| 68490431 | 82728 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 448 | 8 | 2 | 5 | 4.0 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc(C(=O)O)cc3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| CHEMBL2179707 | 82728 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 448 | 8 | 2 | 5 | 4.0 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc(C(=O)O)cc3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| 21252902 | 84575 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 385 | 8 | 1 | 5 | 3.0 | CC(C)n1nc(C(=O)NCC2CCN(CCCN(C)C)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| CHEMBL2179701 | 84575 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 385 | 8 | 1 | 5 | 3.0 | CC(C)n1nc(C(=O)NCC2CCN(CCCN(C)C)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| CHEMBL2220907 | 84575 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 385 | 8 | 1 | 5 | 3.0 | CC(C)n1nc(C(=O)NCC2CCN(CCCN(C)C)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| 70694780 | 76416 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 509 | 12 | 1 | 6 | 5.0 | COC[C@@H]1CCCN1CCCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | |||
| CHEMBL2059582 | 76416 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 509 | 12 | 1 | 6 | 5.0 | COC[C@@H]1CCCN1CCCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | |||
| 252 | 3342 | 3 | None | -1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 332 | 6 | 1 | 4 | 2.7 | CCCCN1CCC(CC1)CNC(=O)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | |||
| 44391713 | 3342 | 3 | None | -1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 332 | 6 | 1 | 4 | 2.7 | CCCCN1CCC(CC1)CNC(=O)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | |||
| CHEMBL182590 | 3342 | 3 | None | -1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 332 | 6 | 1 | 4 | 2.7 | CCCCN1CCC(CC1)CNC(=O)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | |||
| 9973683 | 119807 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 326 | 5 | 1 | 5 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCCCC1 | 10.1021/jm960320m | |||
| CHEMBL348311 | 119807 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 326 | 5 | 1 | 5 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCCCC1 | 10.1021/jm960320m | |||
| 10381762 | 49303 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 326 | 5 | 1 | 5 | 2.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(C)C1 | 10.1021/jm960320m | |||
| CHEMBL156349 | 49303 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 326 | 5 | 1 | 5 | 2.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(C)C1 | 10.1021/jm960320m | |||
| 44213662 | 206597 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 324 | 4 | 1 | 5 | 2.5 | Nc1c(Cl)cc(C(=O)OCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | |||
| CHEMBL88973 | 206597 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 324 | 4 | 1 | 5 | 2.5 | Nc1c(Cl)cc(C(=O)OCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | |||
| 71462650 | 82679 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 372 | 9 | 0 | 5 | 4.9 | CCCCN1CCC(COc2noc3cccc(OCC4CCC4)c23)CC1 | 10.1021/jm300953p | |||
| CHEMBL2179586 | 82679 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 372 | 9 | 0 | 5 | 4.9 | CCCCN1CCC(COc2noc3cccc(OCC4CCC4)c23)CC1 | 10.1021/jm300953p | |||
| 71712466 | 91241 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 439 | 6 | 2 | 4 | 3.4 | CC(=O)N1CCC(CN2CCC(CNC(=O)c3cccc4[nH]c(C(C)C)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | |||
| CHEMBL2401750 | 91241 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 439 | 6 | 2 | 4 | 3.4 | CC(=O)N1CCC(CN2CCC(CNC(=O)c3cccc4[nH]c(C(C)C)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | |||
| 15295138 | 51062 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9 | Binding | ChEMBL | 328 | 5 | 2 | 6 | 1.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(O)C1 | 10.1021/jm960320m | |||
| CHEMBL157880 | 51062 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9 | Binding | ChEMBL | 328 | 5 | 2 | 6 | 1.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(O)C1 | 10.1021/jm960320m | |||
| 235 | 2564 | 42 | None | -4 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0307887 | |||
| 5311299 | 2564 | 42 | None | -4 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0307887 | |||
| CHEMBL286136 | 2564 | 42 | None | -4 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0307887 | |||
| 9800656 | 15550 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | |||
| CHEMBL121913 | 15550 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | |||
| 118712570 | 114232 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 538 | 10 | 2 | 6 | 4.6 | CCCCS(=O)(=O)Nc1ccc(CN2CCC(CNC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmcl.2014.06.083 | |||
| CHEMBL3329804 | 114232 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 538 | 10 | 2 | 6 | 4.6 | CCCCS(=O)(=O)Nc1ccc(CN2CCC(CNC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmcl.2014.06.083 | |||
| 70696825 | 76412 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 479 | 10 | 1 | 5 | 5.4 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCN2CCCCC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | |||
| CHEMBL2059578 | 76412 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 479 | 10 | 1 | 5 | 5.4 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCN2CCCCC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | |||
| 70696826 | 76414 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 467 | 11 | 1 | 5 | 5.2 | CC(C)N(C)CCCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | |||
| CHEMBL2059580 | 76414 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 467 | 11 | 1 | 5 | 5.2 | CC(C)N(C)CCCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | |||
| 10615668 | 186683 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 320 | 6 | 1 | 4 | 3.6 | CCOc1ccccc1NC(=O)OCCN1C[C@@H](C)C[C@@H](C)C1 | 10.1021/jm960853v | |||
| CHEMBL48836 | 186683 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 320 | 6 | 1 | 4 | 3.6 | CCOc1ccccc1NC(=O)OCCN1C[C@@H](C)C[C@@H](C)C1 | 10.1021/jm960853v | |||
| 10690483 | 49300 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 369 | 6 | 2 | 6 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(C)=O)CC1 | 10.1021/jm960320m | |||
| CHEMBL156348 | 49300 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 369 | 6 | 2 | 6 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(C)=O)CC1 | 10.1021/jm960320m | |||
| 235 | 2564 | 42 | None | 4 | 2 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/S0960-894X(01)80508-4 | |||
| 5311299 | 2564 | 42 | None | 4 | 2 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/S0960-894X(01)80508-4 | |||
| CHEMBL286136 | 2564 | 42 | None | 4 | 2 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/S0960-894X(01)80508-4 | |||
| 235 | 2564 | 42 | None | 4 | 2 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm960853v | |||
| 5311299 | 2564 | 42 | None | 4 | 2 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm960853v | |||
| CHEMBL286136 | 2564 | 42 | None | 4 | 2 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm960853v | |||
| 235 | 2564 | 42 | None | 4 | 2 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm960320m | |||
| 5311299 | 2564 | 42 | None | 4 | 2 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm960320m | |||
| CHEMBL286136 | 2564 | 42 | None | 4 | 2 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm960320m | |||
| 53320712 | 56452 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 385 | 6 | 2 | 5 | 2.3 | O=C(O)CCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | |||
| CHEMBL1632171 | 56452 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 385 | 6 | 2 | 5 | 2.3 | O=C(O)CCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | |||
| 71454555 | 79634 | 0 | None | - | 1 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 320 | 6 | 1 | 4 | 3.6 | CCOc1ccccc1NC(=O)OCCN1C[C@H](C)C[C@@H](C)C1 | 10.1021/jm960853v | |||
| CHEMBL2115017 | 79634 | 0 | None | - | 1 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 320 | 6 | 1 | 4 | 3.6 | CCOc1ccccc1NC(=O)OCCN1C[C@H](C)C[C@@H](C)C1 | 10.1021/jm960853v | |||
| 71462776 | 82963 | 0 | None | 125 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 460 | 5 | 0 | 3 | 5.5 | CCCN1CCC(COc2nc3c(I)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | |||
| CHEMBL2181169 | 82963 | 0 | None | 125 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 460 | 5 | 0 | 3 | 5.5 | CCCN1CCC(COc2nc3c(I)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | |||
| 71712325 | 91385 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 554 | 9 | 3 | 7 | 1.6 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(CNC(=O)c3cccc4[nH]c(-c5ccccc5)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | |||
| CHEMBL2402895 | 91385 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 554 | 9 | 3 | 7 | 1.6 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(CNC(=O)c3cccc4[nH]c(-c5ccccc5)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | |||
| 71712463 | 91390 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 465 | 9 | 3 | 6 | 1.4 | CC(C)c1nc2c(C(=O)NCC3CCN(CC(O)CN(C)S(C)(=O)=O)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | |||
| CHEMBL2402900 | 91390 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 465 | 9 | 3 | 6 | 1.4 | CC(C)c1nc2c(C(=O)NCC3CCN(CC(O)CN(C)S(C)(=O)=O)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | |||
| 11293856 | 84609 | 0 | None | 794 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 449 | 8 | 1 | 6 | 4.2 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc([N+](=O)[O-])cc3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| CHEMBL2179705 | 84609 | 0 | None | 794 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 449 | 8 | 1 | 6 | 4.2 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc([N+](=O)[O-])cc3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| CHEMBL2221192 | 84609 | 0 | None | 794 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 449 | 8 | 1 | 6 | 4.2 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc([N+](=O)[O-])cc3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| 53322004 | 56446 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 477 | 10 | 1 | 7 | 4.1 | CCOP(=O)(CCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1)OCC | 10.1016/j.bmc.2010.10.011 | |||
| CHEMBL1632164 | 56446 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 477 | 10 | 1 | 7 | 4.1 | CCOP(=O)(CCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1)OCC | 10.1016/j.bmc.2010.10.011 | |||
| 118712576 | 114238 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 527 | 8 | 2 | 6 | 4.2 | O=C(NCC1CCN(Cc2ccc(NS(=O)(=O)C3CCCCC3)cc2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2014.06.083 | |||
| CHEMBL3329810 | 114238 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 527 | 8 | 2 | 6 | 4.2 | O=C(NCC1CCN(Cc2ccc(NS(=O)(=O)C3CCCCC3)cc2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2014.06.083 | |||
| 118712578 | 114239 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 440 | 6 | 1 | 6 | 3.8 | O=C(OCC1CCN(CC2CCC(C(=O)O)C2)CC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmcl.2014.06.083 | |||
| CHEMBL3329811 | 114239 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 440 | 6 | 1 | 6 | 3.8 | O=C(OCC1CCN(CC2CCC(C(=O)O)C2)CC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmcl.2014.06.083 | |||
| 118712579 | 114240 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 454 | 6 | 1 | 6 | 4.2 | O=C(OCC1CCN(CC2CCCC(C(=O)O)C2)CC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmcl.2014.06.083 | |||
| CHEMBL3329812 | 114240 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 454 | 6 | 1 | 6 | 4.2 | O=C(OCC1CCN(CC2CCCC(C(=O)O)C2)CC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmcl.2014.06.083 | |||
| 44248186 | 195461 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 567 | 15 | 3 | 5 | 6.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN(C)CCc2c[nH]c3ccccc23)CC1 | 10.1021/jm900881j | |||
| CHEMBL552484 | 195461 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 567 | 15 | 3 | 5 | 6.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN(C)CCc2c[nH]c3ccccc23)CC1 | 10.1021/jm900881j | |||
| 119376 | 1841 | 48 | None | -1 | 26 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.bmc.2023.117256 | |||
| 247 | 1841 | 48 | None | -1 | 26 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.bmc.2023.117256 | |||
| CHEMBL33884 | 1841 | 48 | None | -1 | 26 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.bmc.2023.117256 | |||
| 10524522 | 15525 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cnccn2)CC1 | 10.1021/jm0009538 | |||
| CHEMBL121776 | 15525 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cnccn2)CC1 | 10.1021/jm0009538 | |||
| 10548505 | 113104 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cccnn2)CC1 | 10.1021/jm0009538 | |||
| CHEMBL331396 | 113104 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cccnn2)CC1 | 10.1021/jm0009538 | |||
| 52945318 | 17543 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 348 | 6 | 1 | 6 | 2.7 | CCCCN1CCC(COC(=O)c2ccc(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | |||
| CHEMBL1257991 | 17543 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 348 | 6 | 1 | 6 | 2.7 | CCCCN1CCC(COC(=O)c2ccc(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | |||
| 44592414 | 179170 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 332 | 3 | 2 | 3 | 2.8 | C[C@@]12CCCN1CC[C@H]2CNC(=O)c1cc(Cl)cc2nc[nH]c12 | 10.1016/j.bmc.2008.11.045 | |||
| CHEMBL472219 | 179170 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 332 | 3 | 2 | 3 | 2.8 | C[C@@]12CCCN1CC[C@H]2CNC(=O)c1cc(Cl)cc2nc[nH]c12 | 10.1016/j.bmc.2008.11.045 | |||
| 9905514 | 119682 | 0 | None | - | 1 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 328 | 5 | 2 | 6 | 1.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(O)CC1 | 10.1021/jm960320m | |||
| CHEMBL347235 | 119682 | 0 | None | - | 1 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 328 | 5 | 2 | 6 | 1.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(O)CC1 | 10.1021/jm960320m | |||
| 10570203 | 49552 | 0 | None | - | 1 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 355 | 6 | 2 | 6 | 1.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(N)=O)CC1 | 10.1021/jm960320m | |||
| CHEMBL156554 | 49552 | 0 | None | - | 1 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 355 | 6 | 2 | 6 | 1.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(N)=O)CC1 | 10.1021/jm960320m | |||
| 10644148 | 113824 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 390 | 6 | 1 | 7 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccn2)CC1 | 10.1021/jm0009538 | |||
| CHEMBL332553 | 113824 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 390 | 6 | 1 | 7 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccn2)CC1 | 10.1021/jm0009538 | |||
| 11166796 | 82676 | 0 | None | 2 | 2 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | |||
| CHEMBL2179583 | 82676 | 0 | None | 2 | 2 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | |||
| 50898778 | 56455 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 427 | 9 | 2 | 5 | 3.5 | O=C(O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | |||
| CHEMBL1632174 | 56455 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 427 | 9 | 2 | 5 | 3.5 | O=C(O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | |||
| 71712328 | 91388 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 470 | 7 | 2 | 6 | 2.5 | COC(=O)N1CCN(CCN2CCC(CNC(=O)c3cccc4[nH]c(C(C)C)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | |||
| CHEMBL2402898 | 91388 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 470 | 7 | 2 | 6 | 2.5 | COC(=O)N1CCN(CCN2CCC(CNC(=O)c3cccc4[nH]c(C(C)C)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | |||
| 177336 | 3120 | 50 | None | 1412 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2013.09.004 | |||
| 225 | 3120 | 50 | None | 1412 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2013.09.004 | |||
| CHEMBL356359 | 3120 | 50 | None | 1412 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2013.09.004 | |||
| DB04873 | 3120 | 50 | None | 1412 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2013.09.004 | |||
| 118712577 | 114141 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 464 | 6 | 1 | 6 | 3.5 | O=C(OCC1CCN(CC2C3CC4C2C4C3C(=O)O)CC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmcl.2014.06.083 | |||
| CHEMBL3329226 | 114141 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 464 | 6 | 1 | 6 | 3.5 | O=C(OCC1CCN(CC2C3CC4C2C4C3C(=O)O)CC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmcl.2014.06.083 | |||
| 70688535 | 76418 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 586 | 13 | 2 | 7 | 4.2 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCN2CCC(CNS(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | |||
| CHEMBL2059584 | 76418 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 586 | 13 | 2 | 7 | 4.2 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCN2CCC(CNS(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | |||
| 44248184 | 196162 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 525 | 12 | 3 | 5 | 5.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN(C)CCc2c[nH]c3ccccc23)CC1 | 10.1021/jm900881j | |||
| CHEMBL561278 | 196162 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 525 | 12 | 3 | 5 | 5.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN(C)CCc2c[nH]c3ccccc23)CC1 | 10.1021/jm900881j | |||
| 11166796 | 82676 | 0 | None | -2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | |||
| CHEMBL2179583 | 82676 | 0 | None | -2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | |||
| 10854687 | 48556 | 0 | None | - | 1 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 340 | 5 | 1 | 5 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(C)(C)C1 | 10.1021/jm960320m | |||
| CHEMBL155682 | 48556 | 0 | None | - | 1 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 340 | 5 | 1 | 5 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(C)(C)C1 | 10.1021/jm960320m | |||
| 44323244 | 12385 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 378 | 5 | 2 | 3 | 3.0 | CCCC[N+]12CCC(CC1)[C@H](NC(=O)c1cc(Cl)c(N)c3c1OCC3)C2 | 10.1016/0960-894X(96)00002-9 | |||
| CHEMBL1185621 | 12385 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 378 | 5 | 2 | 3 | 3.0 | CCCC[N+]12CCC(CC1)[C@H](NC(=O)c1cc(Cl)c(N)c3c1OCC3)C2 | 10.1016/0960-894X(96)00002-9 | |||
| CHEMBL423504 | 12385 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 378 | 5 | 2 | 3 | 3.0 | CCCC[N+]12CCC(CC1)[C@H](NC(=O)c1cc(Cl)c(N)c3c1OCC3)C2 | 10.1016/0960-894X(96)00002-9 | |||
| 22708808 | 207063 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 365 | 6 | 2 | 4 | 3.1 | CCCCN1CCC(CNC(=O)c2cc(Cl)c(N)c3c2OCC3)CC1 | 10.1016/0960-894X(96)00002-9 | |||
| CHEMBL91771 | 207063 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 365 | 6 | 2 | 4 | 3.1 | CCCCN1CCC(CNC(=O)c2cc(Cl)c(N)c3c2OCC3)CC1 | 10.1016/0960-894X(96)00002-9 | |||
| 71714544 | 91384 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 542 | 9 | 3 | 7 | 1.1 | CC(F)(F)c1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | |||
| CHEMBL2402894 | 91384 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 542 | 9 | 3 | 7 | 1.1 | CC(F)(F)c1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | |||
| 44628200 | 82719 | 0 | None | 1584 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 456 | 7 | 1 | 5 | 5.0 | CC(=O)Nc1ccc(CCN2CCC(COc3nc4ccccc4c4cn(C)cc34)CC2)cc1 | 10.1021/jm300573d | |||
| CHEMBL2179670 | 82719 | 0 | None | 1584 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 456 | 7 | 1 | 5 | 5.0 | CC(=O)Nc1ccc(CCN2CCC(COc3nc4ccccc4c4cn(C)cc34)CC2)cc1 | 10.1021/jm300573d | |||
| 44628198 | 82723 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 443 | 7 | 1 | 5 | 4.8 | Cn1cc2c(OCC3CCN(CCc4ccc(C(=O)O)cc4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | |||
| CHEMBL2179674 | 82723 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 443 | 7 | 1 | 5 | 4.8 | Cn1cc2c(OCC3CCN(CCc4ccc(C(=O)O)cc4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | |||
| 44629279 | 82724 | 0 | None | 39 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 399 | 6 | 0 | 4 | 5.1 | Cn1cc2c(OCC3CCN(CCc4ccccc4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | |||
| CHEMBL2179678 | 82724 | 0 | None | 39 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 399 | 6 | 0 | 4 | 5.1 | Cn1cc2c(OCC3CCN(CCc4ccccc4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | |||
| 53320713 | 56453 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 399 | 7 | 2 | 5 | 2.7 | O=C(O)CCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | |||
| CHEMBL1632172 | 56453 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 399 | 7 | 2 | 5 | 2.7 | O=C(O)CCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | |||
| 70682173 | 76411 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 453 | 7 | 2 | 6 | 3.2 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCCCC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | |||
| CHEMBL2059577 | 76411 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 453 | 7 | 2 | 6 | 3.2 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCCCC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | |||
| 44248189 91900499 | 194846 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 549 | 12 | 2 | 6 | 4.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCC[C@@H]2C(N)=O)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL539713 | 194846 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 549 | 12 | 2 | 6 | 4.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCC[C@@H]2C(N)=O)cc2ccccc21 | 10.1021/jm900881j | |||
| 44248315 | 195921 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 522 | 11 | 1 | 6 | 4.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCOCC2)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL559322 | 195921 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 522 | 11 | 1 | 6 | 4.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCOCC2)cc2ccccc21 | 10.1021/jm900881j | |||
| 11520655 | 132831 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 792 | 19 | 4 | 12 | 4.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCNC(=O)CCC(=O)NCCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| CHEMBL370181 | 132831 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 792 | 19 | 4 | 12 | 4.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCNC(=O)CCC(=O)NCCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| 17755141 | 79125 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 1183 | 28 | 4 | 16 | 9.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCN(CCCc2ccc(CCCN(CCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | |||
| CHEMBL2113289 | 79125 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 1183 | 28 | 4 | 16 | 9.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCN(CCCc2ccc(CCCN(CCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | |||
| 17755141 | 79125 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 1183 | 28 | 4 | 16 | 9.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCN(CCCc2ccc(CCCN(CCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | |||
| CHEMBL2113289 | 79125 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 1183 | 28 | 4 | 16 | 9.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCN(CCCc2ccc(CCCN(CCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | |||
| 44628201 | 82721 | 0 | None | 3 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 429 | 7 | 1 | 5 | 4.6 | Cn1cc2c(OCC3CCN(CCc4ccc(CO)cc4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | |||
| CHEMBL2179672 | 82721 | 0 | None | 3 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 429 | 7 | 1 | 5 | 4.6 | Cn1cc2c(OCC3CCN(CCc4ccc(CO)cc4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | |||
| 11225102 | 76424 | 3 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 466 | 6 | 1 | 6 | 2.5 | CC(=O)N1CCN(CCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2nn(C(C)C)c4ccccc24)C3)CC1 | 10.1016/j.bmcl.2012.05.034 | |||
| CHEMBL2059590 | 76424 | 3 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 466 | 6 | 1 | 6 | 2.5 | CC(=O)N1CCN(CCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2nn(C(C)C)c4ccccc24)C3)CC1 | 10.1016/j.bmcl.2012.05.034 | |||
| 11225102 | 76424 | 3 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 466 | 6 | 1 | 6 | 2.5 | CC(=O)N1CCN(CCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2nn(C(C)C)c4ccccc24)C3)CC1 | 10.1016/j.bmcl.2012.08.051 | |||
| CHEMBL2059590 | 76424 | 3 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 466 | 6 | 1 | 6 | 2.5 | CC(=O)N1CCN(CCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2nn(C(C)C)c4ccccc24)C3)CC1 | 10.1016/j.bmcl.2012.08.051 | |||
| 44248679 | 195599 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 599 | 12 | 1 | 7 | 3.8 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL555693 | 195599 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 599 | 12 | 1 | 7 | 3.8 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | |||
| 44248925 | 196420 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 436 | 9 | 2 | 5 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN2CCCCC2)CC1 | 10.1021/jm900881j | |||
| CHEMBL562902 | 196420 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 436 | 9 | 2 | 5 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN2CCCCC2)CC1 | 10.1021/jm900881j | |||
| 10712297 | 187109 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 341 | 5 | 2 | 5 | 3.2 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCCC(C)C1 | 10.1021/jm960853v | |||
| CHEMBL49155 | 187109 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 341 | 5 | 2 | 5 | 3.2 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCCC(C)C1 | 10.1021/jm960853v | |||
| 44281102 | 116715 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 312 | 4 | 1 | 5 | 2.6 | CCN1CCC(OC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1016/S0960-894X(01)80508-4 | |||
| CHEMBL33732 | 116715 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 312 | 4 | 1 | 5 | 2.6 | CCN1CCC(OC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1016/S0960-894X(01)80508-4 | |||
| 10584 | 1463 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1016/j.ejmech.2018.10.064 | |||
| 86582973 | 1463 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1016/j.ejmech.2018.10.064 | |||
| CHEMBL3417009 | 1463 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1016/j.ejmech.2018.10.064 | |||
| 10584 | 1463 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1016/j.bmcl.2022.128873 | |||
| 86582973 | 1463 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1016/j.bmcl.2022.128873 | |||
| CHEMBL3417009 | 1463 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1016/j.bmcl.2022.128873 | |||
| 235 | 2564 | 42 | None | -4 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | |||
| 5311299 | 2564 | 42 | None | -4 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | |||
| CHEMBL286136 | 2564 | 42 | None | -4 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | |||
| 240 | 944 | 43 | None | -11 | 24 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | |||
| 2769 | 944 | 43 | None | -11 | 24 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | |||
| 44279790 | 944 | 43 | None | -11 | 24 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | |||
| 660 | 944 | 43 | None | -11 | 24 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | |||
| CHEMBL1729 | 944 | 43 | None | -11 | 24 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | |||
| CHEMBL560739 | 944 | 43 | None | -11 | 24 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | |||
| DB00604 | 944 | 43 | None | -11 | 24 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | |||
| 5311047 | 204763 | 33 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC | 10.1016/j.bmcl.2012.05.034 | |||
| CHEMBL74656 | 204763 | 33 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC | 10.1016/j.bmcl.2012.05.034 | |||
| 70682705 | 77503 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 483 | 7 | 3 | 6 | 1.9 | CNC(=O)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | |||
| CHEMBL2087329 | 77503 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 483 | 7 | 3 | 6 | 1.9 | CNC(=O)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | |||
| 70686942 | 77504 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 483 | 7 | 3 | 6 | 1.9 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CNC(=O)N(C)C)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | |||
| CHEMBL2087330 | 77504 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 483 | 7 | 3 | 6 | 1.9 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CNC(=O)N(C)C)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | |||
| 5311047 | 204763 | 33 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC | 10.1016/j.bmcl.2012.08.051 | |||
| CHEMBL74656 | 204763 | 33 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC | 10.1016/j.bmcl.2012.08.051 | |||
| 44248797 | 195712 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 353 | 7 | 2 | 4 | 3.3 | CCCCCN1CCC(NC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm900881j | |||
| CHEMBL557053 | 195712 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 353 | 7 | 2 | 4 | 3.3 | CCCCCN1CCC(NC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm900881j | |||
| 118712568 | 114230 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 516 | 9 | 3 | 4 | 4.8 | O=C(NCC1CCN(Cc2ccc(NS(=O)(=O)Cc3ccccc3)cc2)CC1)c1c[nH]c2ccccc12 | 10.1016/j.bmcl.2014.06.083 | |||
| CHEMBL3329802 | 114230 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 516 | 9 | 3 | 4 | 4.8 | O=C(NCC1CCN(Cc2ccc(NS(=O)(=O)Cc3ccccc3)cc2)CC1)c1c[nH]c2ccccc12 | 10.1016/j.bmcl.2014.06.083 | |||
| 44249189 91900488 | 195402 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 447 | 6 | 2 | 6 | 2.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCS(=O)(=O)O)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL552075 | 195402 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 447 | 6 | 2 | 6 | 2.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCS(=O)(=O)O)cc2ccccc21 | 10.1021/jm900881j | |||
| 44248310 | 196556 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 512 | 6 | 1 | 6 | 3.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2C(=O)c3ccccc3C2=O)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL563799 | 196556 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 512 | 6 | 1 | 6 | 3.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2C(=O)c3ccccc3C2=O)cc2ccccc21 | 10.1021/jm900881j | |||
| 44575 | 197516 | 1 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 311 | 4 | 2 | 4 | 2.1 | CCN1CCC(NC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm900881j | |||
| CHEMBL570074 | 197516 | 1 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 311 | 4 | 2 | 4 | 2.1 | CCN1CCC(NC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm900881j | |||
| 15544715 | 112795 | 4 | None | - | 1 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 272 | 3 | 2 | 3 | 1.8 | CCN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL330605 | 112795 | 4 | None | - | 1 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 272 | 3 | 2 | 3 | 1.8 | CCN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 44327586 | 163831 | 4 | None | - | 1 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 286 | 4 | 2 | 3 | 2.2 | CCCN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL420638 | 163831 | 4 | None | - | 1 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 286 | 4 | 2 | 3 | 2.2 | CCCN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 15544721 | 98973 | 4 | None | - | 1 | Rat | 5.0 | pKi | = | 5 | Binding | ChEMBL | 259 | 2 | 1 | 4 | 1.8 | CN1CCC(OC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL279823 | 98973 | 4 | None | - | 1 | Rat | 5.0 | pKi | = | 5 | Binding | ChEMBL | 259 | 2 | 1 | 4 | 1.8 | CN1CCC(OC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 155525723 | 171085 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 515 | 11 | 3 | 7 | 4.2 | COc1cc(/C=C/C(=O)NCCN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)ccc1O | 10.1016/j.ejmech.2019.111596 | |||
| CHEMBL4457426 | 171085 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 515 | 11 | 3 | 7 | 4.2 | COc1cc(/C=C/C(=O)NCCN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)ccc1O | 10.1016/j.ejmech.2019.111596 | |||
| 10712151 | 120165 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 339 | 5 | 2 | 4 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)NCCN1CC(C)CC(C)C1 | 10.1021/jm960320m | |||
| CHEMBL351557 | 120165 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 339 | 5 | 2 | 4 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)NCCN1CC(C)CC(C)C1 | 10.1021/jm960320m | |||
| 2780 | 110529 | 36 | None | -20 | 10 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 373 | 5 | 2 | 4 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1 | 10.1016/0960-894X(95)00115-A | |||
| CHEMBL325109 | 110529 | 36 | None | -20 | 10 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 373 | 5 | 2 | 4 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1 | 10.1016/0960-894X(95)00115-A | |||
| 5 | 139 | 72 | None | -288 | 54 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm801327q | |||
| 5202 | 139 | 72 | None | -288 | 54 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm801327q | |||
| CHEMBL39 | 139 | 72 | None | -288 | 54 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm801327q | |||
| DB08839 | 139 | 72 | None | -288 | 54 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm801327q | |||
| 136118638 | 76316 | 0 | None | -1 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 335 | 1 | 2 | 3 | 3.1 | CSC1=NC(=O)/C(=C/c2c[nH]c3cccc(Br)c23)N1 | 10.1016/j.bmc.2013.09.011 | |||
| CHEMBL2058698 | 76316 | 0 | None | -1 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 335 | 1 | 2 | 3 | 3.1 | CSC1=NC(=O)/C(=C/c2c[nH]c3cccc(Br)c23)N1 | 10.1016/j.bmc.2013.09.011 | |||
| 5 | 139 | 72 | None | -288 | 54 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2009.01.015 | |||
| 5202 | 139 | 72 | None | -288 | 54 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2009.01.015 | |||
| CHEMBL39 | 139 | 72 | None | -288 | 54 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2009.01.015 | |||
| DB08839 | 139 | 72 | None | -288 | 54 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2009.01.015 | |||
| 11686484 | 132842 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 806 | 20 | 4 | 12 | 4.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCNC(=O)CCCC(=O)NCCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| CHEMBL370182 | 132842 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 806 | 20 | 4 | 12 | 4.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCNC(=O)CCCC(=O)NCCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| 11629240 | 141075 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 806 | 20 | 4 | 12 | 4.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCCCC(=O)NCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| CHEMBL382543 | 141075 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 806 | 20 | 4 | 12 | 4.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCCCC(=O)NCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| 49783421 | 17788 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 352 | 9 | 1 | 5 | 3.3 | CCCCN1CCC(COC(=O)c2ccc(N)c(OCCF)c2)CC1 | 10.1021/jm100668r | |||
| CHEMBL1258786 | 17788 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 352 | 9 | 1 | 5 | 3.3 | CCCCN1CCC(COC(=O)c2ccc(N)c(OCCF)c2)CC1 | 10.1021/jm100668r | |||
| 15544716 | 111395 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 379 | 7 | 3 | 5 | 0.6 | CS(=O)(=O)NCCN1CCC(CNC(=O)c2cccc3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| CHEMBL327192 | 111395 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 379 | 7 | 3 | 5 | 0.6 | CS(=O)(=O)NCCN1CCC(CNC(=O)c2cccc3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| 15544716 | 111395 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 379 | 7 | 3 | 5 | 0.6 | CS(=O)(=O)NCCN1CCC(CNC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL327192 | 111395 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 379 | 7 | 3 | 5 | 0.6 | CS(=O)(=O)NCCN1CCC(CNC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 15544716 | 111395 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 379 | 7 | 3 | 5 | 0.6 | CS(=O)(=O)NCCN1CCC(CNC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL327192 | 111395 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 379 | 7 | 3 | 5 | 0.6 | CS(=O)(=O)NCCN1CCC(CNC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 10739944 | 78755 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 403 | 7 | 1 | 6 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)OCCCN1CCN(c2ccccc2)CC1 | 10.1021/jm0009538 | |||
| CHEMBL2112621 | 78755 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 403 | 7 | 1 | 6 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)OCCCN1CCN(c2ccccc2)CC1 | 10.1021/jm0009538 | |||
| 243 | 3202 | 91 | None | 12 | 34 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/jm020099f | |||
| 3052762 | 3202 | 91 | None | 12 | 34 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/jm020099f | |||
| 3502 | 3202 | 91 | None | 12 | 34 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/jm020099f | |||
| CHEMBL117287 | 3202 | 91 | None | 12 | 34 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/jm020099f | |||
| DB06480 | 3202 | 91 | None | 12 | 34 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/jm020099f | |||
| 44582815 | 173228 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 621 | 11 | 3 | 9 | 3.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCN2C(=O)c3cccc4c(N)ccc(c34)C2=O)CC1 | 10.1021/jm801327q | |||
| CHEMBL452353 | 173228 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 621 | 11 | 3 | 9 | 3.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCN2C(=O)c3cccc4c(N)ccc(c34)C2=O)CC1 | 10.1021/jm801327q | |||
| 11557207 | 79055 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 1203 | 39 | 7 | 18 | 10.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCNc2nc(NCCCCCCCCCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)nc(NCc3ccccc3)n2)CC1 | 10.1021/jm050234z | |||
| CHEMBL2113160 | 79055 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 1203 | 39 | 7 | 18 | 10.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCNc2nc(NCCCCCCCCCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)nc(NCc3ccccc3)n2)CC1 | 10.1021/jm050234z | |||
| 10925529 | 207897 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 329 | 6 | 3 | 4 | 2.4 | CCCCN1CCC(CNC(=O)c2ccc(N)c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL96667 | 207897 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 329 | 6 | 3 | 4 | 2.4 | CCCCN1CCC(CNC(=O)c2ccc(N)c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 132164 | 206648 | 12 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 321 | 2 | 2 | 4 | 1.7 | Nc1c(Cl)cc(C(=O)N[C@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | |||
| CHEMBL89259 | 206648 | 12 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 321 | 2 | 2 | 4 | 1.7 | Nc1c(Cl)cc(C(=O)N[C@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | |||
| 10925529 | 207897 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 329 | 6 | 3 | 4 | 2.4 | CCCCN1CCC(CNC(=O)c2ccc(N)c3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| CHEMBL96667 | 207897 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 329 | 6 | 3 | 4 | 2.4 | CCCCN1CCC(CNC(=O)c2ccc(N)c3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| 10925529 | 207897 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 329 | 6 | 3 | 4 | 2.4 | CCCCN1CCC(CNC(=O)c2ccc(N)c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL96667 | 207897 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 329 | 6 | 3 | 4 | 2.4 | CCCCN1CCC(CNC(=O)c2ccc(N)c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 136118650 | 76323 | 0 | None | -7 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 318 | 1 | 3 | 2 | 2.0 | C/N=C1\NC(=O)/C(=C/c2c[nH]c3cc(Br)ccc23)N1 | 10.1016/j.bmc.2013.09.011 | |||
| CHEMBL2058705 | 76323 | 0 | None | -7 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 318 | 1 | 3 | 2 | 2.0 | C/N=C1\NC(=O)/C(=C/c2c[nH]c3cc(Br)ccc23)N1 | 10.1016/j.bmc.2013.09.011 | |||
| 11039391 | 206284 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 617 | 11 | 2 | 9 | 2.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | |||
| CHEMBL86985 | 206284 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 617 | 11 | 2 | 9 | 2.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | |||
| 42618251 | 186935 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 530 | 14 | 3 | 7 | 3.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCNCCCc2ccccc2)CC1 | 10.1021/jm801327q | |||
| CHEMBL490050 | 186935 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 530 | 14 | 3 | 7 | 3.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCNCCCc2ccccc2)CC1 | 10.1021/jm801327q | |||
| 49783418 | 17715 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 334 | 8 | 1 | 5 | 3.3 | CCCCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1 | 10.1021/jm100668r | |||
| CHEMBL1258561 | 17715 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 334 | 8 | 1 | 5 | 3.3 | CCCCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1 | 10.1021/jm100668r | |||
| 10408029 | 16460 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 389 | 6 | 1 | 6 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2)CC1 | 10.1021/jm0009538 | |||
| CHEMBL123377 | 16460 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 389 | 6 | 1 | 6 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2)CC1 | 10.1021/jm0009538 | |||
| 71714543 | 91383 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 534 | 8 | 3 | 7 | 1.2 | CC(C)(C)c1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | |||
| CHEMBL2402893 | 91383 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 534 | 8 | 3 | 7 | 1.2 | CC(C)(C)c1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | |||
| 11168006 | 76423 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 502 | 7 | 1 | 7 | 1.9 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | |||
| CHEMBL2059589 | 76423 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 502 | 7 | 1 | 7 | 1.9 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | |||
| 44224237 | 194790 | 8 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1016/j.bmcl.2012.05.034 | |||
| CHEMBL538635 | 194790 | 8 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1016/j.bmcl.2012.05.034 | |||
| 44224237 | 194790 | 8 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | |||
| CHEMBL538635 | 194790 | 8 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | |||
| 44224237 | 194790 | 8 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL538635 | 194790 | 8 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | |||
| 155565664 | 175603 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 432 | 8 | 2 | 6 | 4.5 | COc1ccc(CN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1O | 10.1016/j.ejmech.2019.111596 | |||
| CHEMBL4580044 | 175603 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 432 | 8 | 2 | 6 | 4.5 | COc1ccc(CN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1O | 10.1016/j.ejmech.2019.111596 | |||
| 4595 | 176715 | 106 | None | -3 | 15 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 293 | 2 | 0 | 4 | 3.1 | Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O | 10.1021/jm00075a026 | |||
| CHEMBL46 | 176715 | 106 | None | -3 | 15 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 293 | 2 | 0 | 4 | 3.1 | Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O | 10.1021/jm00075a026 | |||
| 10567201 | 184265 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 313 | 5 | 2 | 5 | 2.6 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCCC1 | 10.1021/jm960853v | |||
| CHEMBL48379 | 184265 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 313 | 5 | 2 | 5 | 2.6 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCCC1 | 10.1021/jm960853v | |||
| 240 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | |||
| 2769 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | |||
| 44279790 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | |||
| 660 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | |||
| CHEMBL1729 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | |||
| CHEMBL560739 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | |||
| DB00604 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | |||
| 44629348 | 84583 | 0 | None | -1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 427 | 7 | 0 | 4 | 6.1 | CC(C)n1cc2c(OCC3CCN(CCc4ccccc4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | |||
| CHEMBL2179677 | 84583 | 0 | None | -1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 427 | 7 | 0 | 4 | 6.1 | CC(C)n1cc2c(OCC3CCN(CCc4ccccc4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | |||
| CHEMBL2220955 | 84583 | 0 | None | -1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 427 | 7 | 0 | 4 | 6.1 | CC(C)n1cc2c(OCC3CCN(CCc4ccccc4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | |||
| 44249315 | 195175 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 331 | 4 | 2 | 6 | 0.8 | CC(C)n1c(=O)n(C(=O)NCCN2CCNCC2)c2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL550459 | 195175 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 331 | 4 | 2 | 6 | 0.8 | CC(C)n1c(=O)n(C(=O)NCCN2CCNCC2)c2ccccc21 | 10.1021/jm900881j | |||
| 44248066 | 195186 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 473 | 7 | 2 | 7 | 0.7 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN2CCN(S(C)(=O)=O)CC2)CC1 | 10.1021/jm900881j | |||
| CHEMBL550530 | 195186 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 473 | 7 | 2 | 7 | 0.7 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN2CCN(S(C)(=O)=O)CC2)CC1 | 10.1021/jm900881j | |||
| 44249055 91900481 | 195419 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 367 | 4 | 1 | 4 | 3.3 | CCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1021/jm900881j | |||
| CHEMBL552218 | 195419 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 367 | 4 | 1 | 4 | 3.3 | CCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1021/jm900881j | |||
| 10643698 | 195452 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 383 | 5 | 2 | 5 | 2.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCO)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL552420 | 195452 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 383 | 5 | 2 | 5 | 2.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCO)cc2ccccc21 | 10.1021/jm900881j | |||
| 3233 | 3512 | 44 | None | -933 | 12 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm991151j | |||
| 3247 | 3512 | 44 | None | -933 | 12 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm991151j | |||
| 6604889 | 3512 | 44 | None | -933 | 12 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm991151j | |||
| CHEMBL282199 | 3512 | 44 | None | -933 | 12 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm991151j | |||
| DB13988 | 3512 | 44 | None | -933 | 12 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm991151j | |||
| 44249179 | 194823 | 1 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 312 | 5 | 3 | 5 | 0.6 | COc1cc(N)c(Cl)cc1C(=O)NCCN1CCNCC1 | 10.1021/jm900881j | |||
| CHEMBL539212 | 194823 | 1 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 312 | 5 | 3 | 5 | 0.6 | COc1cc(N)c(Cl)cc1C(=O)NCCN1CCNCC1 | 10.1021/jm900881j | |||
| 11577105 | 72164 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 510 | 16 | 3 | 7 | 4.1 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCN)CC1 | 10.1021/jm050234z | |||
| CHEMBL197965 | 72164 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 510 | 16 | 3 | 7 | 4.1 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCN)CC1 | 10.1021/jm050234z | |||
| 11593090 | 72194 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 834 | 22 | 4 | 12 | 5.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCNC(=O)CCCCCC(=O)NCCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| CHEMBL198052 | 72194 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 834 | 22 | 4 | 12 | 5.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCNC(=O)CCCCCC(=O)NCCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| 44404964 | 72472 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 736 | 15 | 5 | 12 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3O)CC2)CC1 | 10.1021/jm050234z | |||
| CHEMBL198921 | 72472 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 736 | 15 | 5 | 12 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3O)CC2)CC1 | 10.1021/jm050234z | |||
| 130946 | 202758 | 2 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 328 | 2 | 1 | 5 | 2.0 | CCn1c(=O)n(C(=O)NC2CC3CCC(C2)N3C)c2ccccc21 | 10.1016/j.bmc.2008.12.025 | |||
| CHEMBL62023 | 202758 | 2 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 328 | 2 | 1 | 5 | 2.0 | CCn1c(=O)n(C(=O)NC2CC3CCC(C2)N3C)c2ccccc21 | 10.1016/j.bmc.2008.12.025 | |||
| 9839847 | 208246 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 314 | 6 | 2 | 3 | 2.8 | CCCCN1CCC(CNC(=O)c2cccc3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| CHEMBL98734 | 208246 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 314 | 6 | 2 | 3 | 2.8 | CCCCN1CCC(CNC(=O)c2cccc3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| 9839847 | 208246 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 314 | 6 | 2 | 3 | 2.8 | CCCCN1CCC(CNC(=O)c2cccc3[nH]cnc23)CC1 | 10.1039/C0MD00258E | |||
| CHEMBL98734 | 208246 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 314 | 6 | 2 | 3 | 2.8 | CCCCN1CCC(CNC(=O)c2cccc3[nH]cnc23)CC1 | 10.1039/C0MD00258E | |||
| 9839847 | 208246 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 314 | 6 | 2 | 3 | 2.8 | CCCCN1CCC(CNC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL98734 | 208246 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 314 | 6 | 2 | 3 | 2.8 | CCCCN1CCC(CNC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 9839847 | 208246 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 314 | 6 | 2 | 3 | 2.8 | CCCCN1CCC(CNC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL98734 | 208246 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 314 | 6 | 2 | 3 | 2.8 | CCCCN1CCC(CNC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 6604914 | 100384 | 3 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1016/0960-894X(96)00002-9 | |||
| CHEMBL28992 | 100384 | 3 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1016/0960-894X(96)00002-9 | |||
| 203435 | 164104 | 3 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 311 | 5 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NCCN1CCCCC1 | 10.1021/jm960320m | |||
| CHEMBL420969 | 164104 | 3 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 311 | 5 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NCCN1CCCCC1 | 10.1021/jm960320m | |||
| 44404968 | 72355 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 711 | 20 | 3 | 8 | 6.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCC(=O)NC2CCN(Cc3ccccc3)CC2)CC1 | 10.1021/jm050234z | |||
| CHEMBL198504 | 72355 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 711 | 20 | 3 | 8 | 6.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCC(=O)NC2CCN(Cc3ccccc3)CC2)CC1 | 10.1021/jm050234z | |||
| 42618250 | 169461 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 982 | 28 | 6 | 14 | 5.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCNCCCc2ccc(CCCNCCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)cc2)CC1 | 10.1021/jm801327q | |||
| CHEMBL442869 | 169461 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 982 | 28 | 6 | 14 | 5.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCNCCCc2ccc(CCCNCCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)cc2)CC1 | 10.1021/jm801327q | |||
| 10408029 | 16460 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 389 | 6 | 1 | 6 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2)CC1 | 10.1021/jm0009538 | |||
| CHEMBL123377 | 16460 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 389 | 6 | 1 | 6 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2)CC1 | 10.1021/jm0009538 | |||
| 10545215 | 188982 | 0 | None | - | 1 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 341 | 5 | 2 | 5 | 3.4 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCCCCC1 | 10.1021/jm960853v | |||
| CHEMBL50852 | 188982 | 0 | None | - | 1 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 341 | 5 | 2 | 5 | 3.4 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCCCCC1 | 10.1021/jm960853v | |||
| 42646835 | 195154 | 2 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 261 | 4 | 2 | 4 | 1.5 | COc1ccc2[nH]cc(CNN3CCOCC3)c2c1 | 10.1016/j.ejmech.2009.01.015 | |||
| CHEMBL550302 | 195154 | 2 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 261 | 4 | 2 | 4 | 1.5 | COc1ccc2[nH]cc(CNN3CCOCC3)c2c1 | 10.1016/j.ejmech.2009.01.015 | |||
| 70695321 | 77500 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 455 | 7 | 4 | 6 | 1.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CNC(N)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | |||
| CHEMBL2087326 | 77500 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 455 | 7 | 4 | 6 | 1.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CNC(N)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | |||
| 44247822 91900495 | 195515 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 571 | 10 | 1 | 7 | 3.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL553685 | 195515 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 571 | 10 | 1 | 7 | 3.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | |||
| 44248434 91900496 | 195639 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 613 | 13 | 1 | 7 | 4.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL556326 | 195639 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 613 | 13 | 1 | 7 | 4.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | |||
| 44248070 | 195824 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 557 | 13 | 2 | 7 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN2CCN(S(C)(=O)=O)CC2)CC1 | 10.1021/jm900881j | |||
| CHEMBL558261 | 195824 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 557 | 13 | 2 | 7 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN2CCN(S(C)(=O)=O)CC2)CC1 | 10.1021/jm900881j | |||
| 44248552 91900486 | 195919 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 554 | 9 | 1 | 6 | 4.8 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN2C(=O)c3ccccc3C2=O)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL559317 | 195919 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 554 | 9 | 1 | 6 | 4.8 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN2C(=O)c3ccccc3C2=O)cc2ccccc21 | 10.1021/jm900881j | |||
| 10615288 | 187009 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 315 | 7 | 2 | 5 | 2.8 | CCN(CC)CCOC(=O)Nc1cc(Cl)c(N)cc1OC | 10.1021/jm960853v | |||
| CHEMBL49072 | 187009 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 315 | 7 | 2 | 5 | 2.8 | CCN(CC)CCOC(=O)Nc1cc(Cl)c(N)cc1OC | 10.1021/jm960853v | |||
| 134828069 | 173302 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 410 | 7 | 1 | 3 | 5.7 | COc1c(C(=O)CCC2CCN(Cc3ccccc3)CC2)cc(Cl)c2[nH]ccc12 | 10.1016/j.ejmech.2018.10.064 | |||
| CHEMBL4526050 | 173302 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 410 | 7 | 1 | 3 | 5.7 | COc1c(C(=O)CCC2CCN(Cc3ccccc3)CC2)cc(Cl)c2[nH]ccc12 | 10.1016/j.ejmech.2018.10.064 | |||
| 9819593 | 98804 | 3 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2 | 10.1021/jm960320m | |||
| CHEMBL27846 | 98804 | 3 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2 | 10.1021/jm960320m | |||
| 108182 | 4131 | 22 | None | -1 | 16 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 10.1016/0960-894X(96)00200-4 | |||
| 245 | 4131 | 22 | None | -1 | 16 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 10.1016/0960-894X(96)00200-4 | |||
| CHEMBL18041 | 4131 | 22 | None | -1 | 16 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 10.1016/0960-894X(96)00200-4 | |||
| 15231247 91900477 | 195652 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 309 | 3 | 3 | 4 | 1.9 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1C[C@@H]2CC[C@H](C1)N2 | 10.1021/jm900881j | |||
| CHEMBL556438 | 195652 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 309 | 3 | 3 | 4 | 1.9 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1C[C@@H]2CC[C@H](C1)N2 | 10.1021/jm900881j | |||
| 42499 | 194937 | 23 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 283 | 3 | 3 | 4 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)NC1CCNCC1 | 10.1021/jm900881j | |||
| CHEMBL541969 | 194937 | 23 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 283 | 3 | 3 | 4 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)NC1CCNCC1 | 10.1021/jm900881j | |||
| 44248794 | 195512 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 302 | 2 | 2 | 5 | 1.7 | CC(C)n1c(=O)n(C(=O)NC2CCNCC2)c2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL553658 | 195512 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 302 | 2 | 2 | 5 | 1.7 | CC(C)n1c(=O)n(C(=O)NC2CCNCC2)c2ccccc21 | 10.1021/jm900881j | |||
| 44247817 91900489 | 195975 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 489 | 9 | 2 | 6 | 3.4 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCS(=O)(=O)O)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL559746 | 195975 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 489 | 9 | 2 | 6 | 3.4 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCS(=O)(=O)O)cc2ccccc21 | 10.1021/jm900881j | |||
| 9935387 | 99442 | 0 | None | -1995 | 14 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 491 | 5 | 1 | 6 | 5.0 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1 | 10.1016/s0960-894x(02)00172-5 | |||
| CHEMBL282971 | 99442 | 0 | None | -1995 | 14 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 491 | 5 | 1 | 6 | 5.0 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1 | 10.1016/s0960-894x(02)00172-5 | |||
| 44247949 | 195114 | 0 | None | - | 1 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 475 | 12 | 3 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCS(=O)(=O)O)CC1 | 10.1021/jm900881j | |||
| CHEMBL549998 | 195114 | 0 | None | - | 1 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 475 | 12 | 3 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCS(=O)(=O)O)CC1 | 10.1021/jm900881j | |||
| 11600413 | 67524 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 876 | 25 | 4 | 12 | 6.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCCCCCCCCC(=O)NCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| CHEMBL189580 | 67524 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 876 | 25 | 4 | 12 | 6.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCCCCCCCCC(=O)NCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| 44404962 | 72545 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 834 | 22 | 5 | 12 | 5.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3O)CC2)CC1 | 10.1021/jm050234z | |||
| CHEMBL199150 | 72545 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 834 | 22 | 5 | 12 | 5.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3O)CC2)CC1 | 10.1021/jm050234z | |||
| 10645103 | 164341 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 407 | 6 | 1 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2F)CC1 | 10.1021/jm0009538 | |||
| CHEMBL421256 | 164341 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 407 | 6 | 1 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2F)CC1 | 10.1021/jm0009538 | |||
| 10645984 | 18817 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cccc(Cl)c2)CC1 | 10.1021/jm0009538 | |||
| CHEMBL127876 | 18817 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cccc(Cl)c2)CC1 | 10.1021/jm0009538 | |||
| 11841878 | 67597 | 4 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 332 | 2 | 2 | 3 | 3.0 | CN1C2CCCC1CC(NC(=O)c1cc(Cl)cc3[nH]cnc13)C2 | 10.1016/0960-894X(96)00200-4 | |||
| CHEMBL19022 | 67597 | 4 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 332 | 2 | 2 | 3 | 3.0 | CN1C2CCCC1CC(NC(=O)c1cc(Cl)cc3[nH]cnc13)C2 | 10.1016/0960-894X(96)00200-4 | |||
| 11841878 | 67597 | 4 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 332 | 2 | 2 | 3 | 3.0 | CN1C2CCCC1CC(NC(=O)c1cc(Cl)cc3[nH]cnc13)C2 | 10.1021/jm991076c | |||
| CHEMBL19022 | 67597 | 4 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 332 | 2 | 2 | 3 | 3.0 | CN1C2CCCC1CC(NC(=O)c1cc(Cl)cc3[nH]cnc13)C2 | 10.1021/jm991076c | |||
| 10859701 | 67583 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 304 | 2 | 2 | 3 | 2.0 | O=C(NC1CN2CCC1CC2)c1cc(Cl)cc2nc[nH]c12 | 10.1016/0960-894X(96)00200-4 | |||
| CHEMBL19006 | 67583 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 304 | 2 | 2 | 3 | 2.0 | O=C(NC1CN2CCC1CC2)c1cc(Cl)cc2nc[nH]c12 | 10.1016/0960-894X(96)00200-4 | |||
| 10859701 | 67583 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 304 | 2 | 2 | 3 | 2.0 | O=C(NC1CN2CCC1CC2)c1cc(Cl)cc2nc[nH]c12 | 10.1021/jm991076c | |||
| CHEMBL19006 | 67583 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 304 | 2 | 2 | 3 | 2.0 | O=C(NC1CN2CCC1CC2)c1cc(Cl)cc2nc[nH]c12 | 10.1021/jm991076c | |||
| 11841879 | 121013 | 7 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 348 | 2 | 2 | 3 | 2.1 | O=C(NC1CN2CCC1CC2)c1cc(Br)cc2nc[nH]c12 | 10.1021/jm991076c | |||
| CHEMBL356521 | 121013 | 7 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 348 | 2 | 2 | 3 | 2.1 | O=C(NC1CN2CCC1CC2)c1cc(Br)cc2nc[nH]c12 | 10.1021/jm991076c | |||
| 9924349 | 175867 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 346 | 6 | 1 | 2 | 5.0 | O=C(CCC1CCN(Cc2ccccc2)CC1)c1ccc2[nH]ccc2c1 | 10.1016/j.ejmech.2018.10.064 | |||
| CHEMBL4585990 | 175867 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 346 | 6 | 1 | 2 | 5.0 | O=C(CCC1CCN(Cc2ccccc2)CC1)c1ccc2[nH]ccc2c1 | 10.1016/j.ejmech.2018.10.064 | |||
| 9905225 | 206944 | 0 | None | - | 1 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 321 | 2 | 2 | 4 | 1.7 | Nc1c(Cl)cc(C(=O)N[C@@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | |||
| CHEMBL91147 | 206944 | 0 | None | - | 1 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 321 | 2 | 2 | 4 | 1.7 | Nc1c(Cl)cc(C(=O)N[C@@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | |||
| 49783417 | 17714 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 306 | 6 | 1 | 5 | 2.6 | CCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1 | 10.1021/jm100668r | |||
| CHEMBL1258560 | 17714 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 306 | 6 | 1 | 5 | 2.6 | CCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1 | 10.1021/jm100668r | |||
| 49783420 | 17750 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 338 | 8 | 1 | 5 | 3.2 | CCCCN1CCC(COC(=O)c2ccc(N)c(OCF)c2)CC1 | 10.1021/jm100668r | |||
| CHEMBL1258672 | 17750 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 338 | 8 | 1 | 5 | 3.2 | CCCCN1CCC(COC(=O)c2ccc(N)c(OCF)c2)CC1 | 10.1021/jm100668r | |||
| 71461049 | 82975 | 0 | None | 1 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 4.9 | CCCN1CCC(COc2nc3c(OC)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | |||
| CHEMBL2181187 | 82975 | 0 | None | 1 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 4.9 | CCCN1CCC(COc2nc3c(OC)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | |||
| 10669778 | 117475 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 419 | 7 | 1 | 7 | 2.9 | COc1ccc(N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1 | 10.1021/jm0009538 | |||
| CHEMBL339936 | 117475 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 419 | 7 | 1 | 7 | 2.9 | COc1ccc(N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1 | 10.1021/jm0009538 | |||
| 10267187 | 206498 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 306 | 2 | 1 | 3 | 2.1 | O=C(N[C@@H]1CN2CCC1CC2)c1cc(Cl)cc2c1OCC2 | 10.1016/0960-894X(96)00002-9 | |||
| CHEMBL88310 | 206498 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 306 | 2 | 1 | 3 | 2.1 | O=C(N[C@@H]1CN2CCC1CC2)c1cc(Cl)cc2c1OCC2 | 10.1016/0960-894X(96)00002-9 | |||
| 10331436 | 324 | 10 | None | -851 | 6 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 230 | 2 | 2 | 2 | 2.4 | C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N | 10.1021/jm030205t | |||
| 160 | 324 | 10 | None | -851 | 6 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 230 | 2 | 2 | 2 | 2.4 | C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N | 10.1021/jm030205t | |||
| CHEMBL133455 | 324 | 10 | None | -851 | 6 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 230 | 2 | 2 | 2 | 2.4 | C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N | 10.1021/jm030205t | |||
| 11146446 | 105954 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 603 | 10 | 2 | 9 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | |||
| CHEMBL312940 | 105954 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 603 | 10 | 2 | 9 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | |||
| 11714901 | 134332 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 904 | 27 | 4 | 12 | 7.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCNC(=O)CCCCCCCCCCC(=O)NCCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| CHEMBL371718 | 134332 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 904 | 27 | 4 | 12 | 7.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCNC(=O)CCCCCCCCCCC(=O)NCCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| 10919426 | 206220 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 659 | 14 | 2 | 9 | 4.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CCCCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | |||
| CHEMBL86624 | 206220 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 659 | 14 | 2 | 9 | 4.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CCCCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | |||
| 9856041 | 24114 | 3 | None | -489 | 8 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 230 | 2 | 2 | 2 | 2.4 | CC(N)Cc1c[nH]c2ccc3c(c12)CCCO3 | 10.1021/jm030205t | |||
| CHEMBL133868 | 24114 | 3 | None | -489 | 8 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 230 | 2 | 2 | 2 | 2.4 | CC(N)Cc1c[nH]c2ccc3c(c12)CCCO3 | 10.1021/jm030205t | |||
| 11813759 | 206296 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 564 | 8 | 1 | 8 | 4.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CN2C(=O)c3cccc4c(N(C)C)ccc(c34)C2=O)CC1 | 10.1021/jm0307887 | |||
| CHEMBL87063 | 206296 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 564 | 8 | 1 | 8 | 4.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CN2C(=O)c3cccc4c(N(C)C)ccc(c34)C2=O)CC1 | 10.1021/jm0307887 | |||
| 11050452 | 49147 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 631 | 12 | 2 | 9 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | |||
| CHEMBL156206 | 49147 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 631 | 12 | 2 | 9 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | |||
| 5 | 139 | 72 | None | -117 | 54 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm960320m | |||
| 5202 | 139 | 72 | None | -117 | 54 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm960320m | |||
| CHEMBL39 | 139 | 72 | None | -117 | 54 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm960320m | |||
| DB08839 | 139 | 72 | None | -117 | 54 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm960320m | |||
| 10615623 | 157123 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 319 | 2 | 3 | 4 | 1.6 | Nc1c(Cl)cc(C(=O)NC2CN3CCC2CC3)c2[nH]cnc12 | 10.1021/jm991076c | |||
| CHEMBL407493 | 157123 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 319 | 2 | 3 | 4 | 1.6 | Nc1c(Cl)cc(C(=O)NC2CN3CCC2CC3)c2[nH]cnc12 | 10.1021/jm991076c | |||
| 11527897 | 134299 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 780 | 18 | 4 | 13 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCOCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| CHEMBL371707 | 134299 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 780 | 18 | 4 | 13 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCOCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| 67251061 | 82720 | 0 | None | 10 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 443 | 8 | 0 | 5 | 5.2 | COCc1ccc(CCN2CCC(COc3nc4ccccc4c4cn(C)cc34)CC2)cc1 | 10.1021/jm300573d | |||
| CHEMBL2179671 | 82720 | 0 | None | 10 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 443 | 8 | 0 | 5 | 5.2 | COCc1ccc(CCN2CCC(COc3nc4ccccc4c4cn(C)cc34)CC2)cc1 | 10.1021/jm300573d | |||
| 11842633 | 3981 | 21 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 10.1016/j.bmcl.2012.08.051 | |||
| 8425 | 3981 | 21 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 10.1016/j.bmcl.2012.08.051 | |||
| CHEMBL2087337 | 3981 | 21 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 10.1016/j.bmcl.2012.08.051 | |||
| 67276168 | 77508 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 490 | 8 | 3 | 7 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CNS(C)(=O)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | |||
| CHEMBL2087334 | 77508 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 490 | 8 | 3 | 7 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CNS(C)(=O)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | |||
| 11432106 | 77509 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN(C)S(C)(=O)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | |||
| CHEMBL2087335 | 77509 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN(C)S(C)(=O)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | |||
| 11519716 | 195496 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL553405 | 195496 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | |||
| 44247941 | 195788 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 498 | 9 | 2 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN2C(=O)c3ccccc3C2=O)CC1 | 10.1021/jm900881j | |||
| CHEMBL557867 | 195788 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 498 | 9 | 2 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN2C(=O)c3ccccc3C2=O)CC1 | 10.1021/jm900881j | |||
| 10028436 | 3532 | 5 | None | -954 | 12 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 487 | 7 | 1 | 4 | 4.9 | Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 | 10.1016/s0960-894x(02)00690-x | |||
| 3237 | 3532 | 5 | None | -954 | 12 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 487 | 7 | 1 | 4 | 4.9 | Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 | 10.1016/s0960-894x(02)00690-x | |||
| CHEMBL95104 | 3532 | 5 | None | -954 | 12 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 487 | 7 | 1 | 4 | 4.9 | Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 | 10.1016/s0960-894x(02)00690-x | |||
| 11177588 | 95189 | 5 | None | -5 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 418 | 5 | 6 | 3 | 1.1 | N=C(N)NCCC[C@@H]1NC(=O)/C(=C/c2c[nH]c3cc(Br)ccc23)NC1=O | 10.1021/np0601760 | |||
| CHEMBL255898 | 95189 | 5 | None | -5 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 418 | 5 | 6 | 3 | 1.1 | N=C(N)NCCC[C@@H]1NC(=O)/C(=C/c2c[nH]c3cc(Br)ccc23)NC1=O | 10.1021/np0601760 | |||
| 10623729 | 113086 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 457 | 6 | 1 | 6 | 3.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 | 10.1021/jm0009538 | |||
| CHEMBL331264 | 113086 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 457 | 6 | 1 | 6 | 3.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 | 10.1021/jm0009538 | |||
| 260 | 3869 | 54 | None | -38 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/j.bmc.2008.11.045 | |||
| 2775 | 3869 | 54 | None | -38 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/j.bmc.2008.11.045 | |||
| 656665 | 3869 | 54 | None | -38 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/j.bmc.2008.11.045 | |||
| CHEMBL56564 | 3869 | 54 | None | -38 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/j.bmc.2008.11.045 | |||
| DB11699 | 3869 | 54 | None | -38 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/j.bmc.2008.11.045 | |||
| 44628269 | 82722 | 0 | None | 3 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 443 | 7 | 1 | 5 | 4.8 | Cn1cc2c(OCC3CCN(CCc4ccccc4C(=O)O)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | |||
| CHEMBL2179673 | 82722 | 0 | None | 3 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 443 | 7 | 1 | 5 | 4.8 | Cn1cc2c(OCC3CCN(CCc4ccccc4C(=O)O)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | |||
| 44248317 | 195899 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 559 | 12 | 1 | 7 | 2.9 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN(C)CCCN(C)S(C)(=O)=O)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL559050 | 195899 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 559 | 12 | 1 | 7 | 2.9 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN(C)CCCN(C)S(C)(=O)=O)cc2ccccc21 | 10.1021/jm900881j | |||
| 20030109 | 196351 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 327 | 5 | 3 | 5 | 1.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCO)CC1 | 10.1021/jm900881j | |||
| CHEMBL562477 | 196351 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 327 | 5 | 3 | 5 | 1.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCO)CC1 | 10.1021/jm900881j | |||
| 15295138 | 51062 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 328 | 5 | 2 | 6 | 1.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(O)C1 | 10.1021/jm960320m | |||
| CHEMBL157880 | 51062 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 328 | 5 | 2 | 6 | 1.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(O)C1 | 10.1021/jm960320m | |||
| 10741078 | 112840 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 425 | 6 | 1 | 8 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccc(Cl)nn2)CC1 | 10.1021/jm0009538 | |||
| CHEMBL330848 | 112840 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 425 | 6 | 1 | 8 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccc(Cl)nn2)CC1 | 10.1021/jm0009538 | |||
| 42618252 | 186680 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 580 | 13 | 3 | 8 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCNS(=O)(=O)c2ccc(C)cc2)CC1 | 10.1021/jm801327q | |||
| CHEMBL488325 | 186680 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 580 | 13 | 3 | 8 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCNS(=O)(=O)c2ccc(C)cc2)CC1 | 10.1021/jm801327q | |||
| 49783209 | 17609 | 0 | None | 21 | 26 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 396 | 7 | 1 | 6 | 3.8 | CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | |||
| CHEMBL1258223 | 17609 | 0 | None | 21 | 26 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 396 | 7 | 1 | 6 | 3.8 | CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | |||
| 53321958 | 56454 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 413 | 8 | 2 | 5 | 3.1 | O=C(O)CCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | |||
| CHEMBL1632173 | 56454 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 413 | 8 | 2 | 5 | 3.1 | O=C(O)CCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | |||
| 49783419 | 17749 | 0 | None | 41 | 12 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 366 | 6 | 1 | 6 | 2.8 | CCCCN1CCC(COC(=O)c2cc(F)c(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | |||
| CHEMBL1258671 | 17749 | 0 | None | 41 | 12 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 366 | 6 | 1 | 6 | 2.8 | CCCCN1CCC(COC(=O)c2cc(F)c(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | |||
| 5324247 | 208055 | 1 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 362 | 5 | 1 | 4 | 3.3 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3c2ncn3C)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL97594 | 208055 | 1 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 362 | 5 | 1 | 4 | 3.3 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3c2ncn3C)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 5324247 | 208055 | 1 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 362 | 5 | 1 | 4 | 3.3 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3c2ncn3C)CC1 | 10.1021/jm020807x | |||
| CHEMBL97594 | 208055 | 1 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 362 | 5 | 1 | 4 | 3.3 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3c2ncn3C)CC1 | 10.1021/jm020807x | |||
| 257 | 3493 | 13 | None | -1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 474 | 6 | 1 | 6 | 3.3 | CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N | 10.1021/jm100668r | |||
| 5311423 | 3493 | 13 | None | -1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 474 | 6 | 1 | 6 | 3.3 | CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N | 10.1021/jm100668r | |||
| CHEMBL114112 | 3493 | 13 | None | -1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 474 | 6 | 1 | 6 | 3.3 | CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N | 10.1021/jm100668r | |||
| 5324247 | 208055 | 1 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 362 | 5 | 1 | 4 | 3.3 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3c2ncn3C)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL97594 | 208055 | 1 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 362 | 5 | 1 | 4 | 3.3 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3c2ncn3C)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 15544728 | 207553 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 414 | 7 | 2 | 6 | 1.6 | CS(=O)(=O)NCCN1CCC(COC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL94784 | 207553 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 414 | 7 | 2 | 6 | 1.6 | CS(=O)(=O)NCCN1CCC(COC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 15544728 | 207553 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 414 | 7 | 2 | 6 | 1.6 | CS(=O)(=O)NCCN1CCC(COC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| CHEMBL94784 | 207553 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 414 | 7 | 2 | 6 | 1.6 | CS(=O)(=O)NCCN1CCC(COC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| 15544728 | 207553 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 414 | 7 | 2 | 6 | 1.6 | CS(=O)(=O)NCCN1CCC(COC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL94784 | 207553 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 414 | 7 | 2 | 6 | 1.6 | CS(=O)(=O)NCCN1CCC(COC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 249 | 2565 | 4 | None | -1 | 2 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10.1021/jm960320m | |||
| 9905972 | 2565 | 4 | None | -1 | 2 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10.1021/jm960320m | |||
| CHEMBL155917 | 2565 | 4 | None | -1 | 2 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10.1021/jm960320m | |||
| 10522209 | 101696 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 355 | 5 | 2 | 5 | 3.5 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CC(C)CC(C)C1 | 10.1021/jm960853v | |||
| CHEMBL299408 | 101696 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 355 | 5 | 2 | 5 | 3.5 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CC(C)CC(C)C1 | 10.1021/jm960853v | |||
| 49783415 | 17678 | 0 | None | 416 | 12 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 320 | 7 | 1 | 5 | 2.9 | CCCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1 | 10.1021/jm100668r | |||
| CHEMBL1258452 | 17678 | 0 | None | 416 | 12 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 320 | 7 | 1 | 5 | 2.9 | CCCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1 | 10.1021/jm100668r | |||
| 53318013 | 56456 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 511 | 15 | 2 | 5 | 5.9 | O=C(O)CCCCCCCCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | |||
| CHEMBL1632175 | 56456 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 511 | 15 | 2 | 5 | 5.9 | O=C(O)CCCCCCCCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | |||
| 9800656 | 15550 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | |||
| CHEMBL121913 | 15550 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | |||
| 243 | 3202 | 91 | None | 12 | 34 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.bmc.2008.11.045 | |||
| 3052762 | 3202 | 91 | None | 12 | 34 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.bmc.2008.11.045 | |||
| 3502 | 3202 | 91 | None | 12 | 34 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.bmc.2008.11.045 | |||
| CHEMBL117287 | 3202 | 91 | None | 12 | 34 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.bmc.2008.11.045 | |||
| DB06480 | 3202 | 91 | None | 12 | 34 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.bmc.2008.11.045 | |||
| 44629350 | 84582 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 408 | 6 | 0 | 6 | 3.2 | Cn1cc2c(OCC3CCN(CCN4CCOCC4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | |||
| CHEMBL2179676 | 84582 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 408 | 6 | 0 | 6 | 3.2 | Cn1cc2c(OCC3CCN(CCN4CCOCC4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | |||
| CHEMBL2220954 | 84582 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 408 | 6 | 0 | 6 | 3.2 | Cn1cc2c(OCC3CCN(CCN4CCOCC4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | |||
| 67472601 | 92875 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 548 | 7 | 1 | 8 | 5.3 | O=C(OCC1CCN(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)CC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmc.2013.09.004 | |||
| CHEMBL2440456 | 92875 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 548 | 7 | 1 | 8 | 5.3 | O=C(OCC1CCN(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)CC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmc.2013.09.004 | |||
| 70686434 | 76417 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 560 | 10 | 3 | 8 | 2.0 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCC(CNS(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | |||
| CHEMBL2059583 | 76417 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 560 | 10 | 3 | 8 | 2.0 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCC(CNS(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | |||
| 70684288 | 76420 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 558 | 11 | 1 | 7 | 3.5 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | |||
| CHEMBL2059586 | 76420 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 558 | 11 | 1 | 7 | 3.5 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | |||
| 11504722 | 76422 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 532 | 8 | 2 | 8 | 1.3 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | |||
| CHEMBL2059588 | 76422 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 532 | 8 | 2 | 8 | 1.3 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | |||
| 44248922 | 194900 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 627 | 14 | 2 | 7 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCC(CNS(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL540981 | 194900 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 627 | 14 | 2 | 7 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCC(CNS(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | |||
| 44248921 | 195246 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 520 | 11 | 1 | 5 | 5.7 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL551013 | 195246 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 520 | 11 | 1 | 5 | 5.7 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | |||
| 41585 | 101621 | 3 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 292 | 6 | 1 | 4 | 3.1 | CCOc1ccccc1NC(=O)OCCN1CCCCC1 | 10.1021/jm960853v | |||
| CHEMBL298920 | 101621 | 3 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 292 | 6 | 1 | 4 | 3.1 | CCOc1ccccc1NC(=O)OCCN1CCCCC1 | 10.1021/jm960853v | |||
| 10566592 | 185887 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 306 | 5 | 1 | 4 | 3.2 | COc1ccccc1NC(=O)OCCN1C[C@@H](C)C[C@@H](C)C1 | 10.1021/jm960853v | |||
| CHEMBL48684 | 185887 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 306 | 5 | 1 | 4 | 3.2 | COc1ccccc1NC(=O)OCCN1C[C@@H](C)C[C@@H](C)C1 | 10.1021/jm960853v | |||
| 71451950 | 82675 | 8 | None | -1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | |||
| CHEMBL2179582 | 82675 | 8 | None | -1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | |||
| 53324017 | 56451 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 371 | 5 | 2 | 5 | 2.0 | O=C(O)CN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | |||
| CHEMBL1632170 | 56451 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 371 | 5 | 2 | 5 | 2.0 | O=C(O)CN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | |||
| 15544727 | 107242 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 349 | 6 | 1 | 4 | 3.9 | CCCCN1CCC(COC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL316856 | 107242 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 349 | 6 | 1 | 4 | 3.9 | CCCCN1CCC(COC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 15544727 | 107242 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 349 | 6 | 1 | 4 | 3.9 | CCCCN1CCC(COC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| CHEMBL316856 | 107242 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 349 | 6 | 1 | 4 | 3.9 | CCCCN1CCC(COC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| 15544727 | 107242 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 349 | 6 | 1 | 4 | 3.9 | CCCCN1CCC(COC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL316856 | 107242 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 349 | 6 | 1 | 4 | 3.9 | CCCCN1CCC(COC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 11622025 | 143746 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 848 | 23 | 4 | 12 | 6.1 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| CHEMBL390075 | 143746 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 848 | 23 | 4 | 12 | 6.1 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| 11686510 | 72314 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 820 | 21 | 2 | 12 | 5.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CCCCCCCCCCC(=O)N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| CHEMBL198372 | 72314 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 820 | 21 | 2 | 12 | 5.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CCCCCCCCCCC(=O)N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| 1235483 | 38000 | 1 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 304 | 2 | 2 | 3 | 2.0 | O=C(N[C@H]1CN2CCC1CC2)c1cc(Cl)cc2nc[nH]c12 | 10.1021/jm991076c | |||
| CHEMBL146012 | 38000 | 1 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 304 | 2 | 2 | 3 | 2.0 | O=C(N[C@H]1CN2CCC1CC2)c1cc(Cl)cc2nc[nH]c12 | 10.1021/jm991076c | |||
| 11650641 | 72089 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 736 | 15 | 4 | 12 | 3.1 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| CHEMBL197751 | 72089 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 736 | 15 | 4 | 12 | 3.1 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| 11810608 | 208054 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 363 | 6 | 3 | 4 | 3.0 | CCCCN1CCC(CNC(=O)c2cc(Cl)c(N)c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL97591 | 208054 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 363 | 6 | 3 | 4 | 3.0 | CCCCN1CCC(CNC(=O)c2cc(Cl)c(N)c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 11810608 | 208054 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 363 | 6 | 3 | 4 | 3.0 | CCCCN1CCC(CNC(=O)c2cc(Cl)c(N)c3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| CHEMBL97591 | 208054 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 363 | 6 | 3 | 4 | 3.0 | CCCCN1CCC(CNC(=O)c2cc(Cl)c(N)c3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| 11810608 | 208054 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 363 | 6 | 3 | 4 | 3.0 | CCCCN1CCC(CNC(=O)c2cc(Cl)c(N)c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL97591 | 208054 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 363 | 6 | 3 | 4 | 3.0 | CCCCN1CCC(CNC(=O)c2cc(Cl)c(N)c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 136118637 | 76315 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 321 | 1 | 3 | 2 | 2.3 | O=C1NC(=S)N/C1=C\c1c[nH]c2c(Br)cccc12 | 10.1016/j.bmc.2013.09.011 | |||
| CHEMBL2058697 | 76315 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 321 | 1 | 3 | 2 | 2.3 | O=C1NC(=S)N/C1=C\c1c[nH]c2c(Br)cccc12 | 10.1016/j.bmc.2013.09.011 | |||
| 136118649 | 76322 | 0 | None | -2 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 318 | 1 | 3 | 2 | 2.0 | C/N=C1\NC(=O)/C(=C/c2c[nH]c3ccc(Br)cc23)N1 | 10.1016/j.bmc.2013.09.011 | |||
| CHEMBL2058704 | 76322 | 0 | None | -2 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 318 | 1 | 3 | 2 | 2.0 | C/N=C1\NC(=O)/C(=C/c2c[nH]c3ccc(Br)cc23)N1 | 10.1016/j.bmc.2013.09.011 | |||
| 10618741 | 165679 | 0 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 363 | 2 | 3 | 4 | 1.7 | Nc1c(Br)cc(C(=O)NC2CN3CCC2CC3)c2[nH]cnc12 | 10.1021/jm991076c | |||
| CHEMBL424498 | 165679 | 0 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 363 | 2 | 3 | 4 | 1.7 | Nc1c(Br)cc(C(=O)NC2CN3CCC2CC3)c2[nH]cnc12 | 10.1021/jm991076c | |||
| 44281492 | 118872 | 2 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 298 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)OC1CCN(C)CC1 | 10.1016/S0960-894X(01)80508-4 | |||
| CHEMBL34224 | 118872 | 2 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 298 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)OC1CCN(C)CC1 | 10.1016/S0960-894X(01)80508-4 | |||
| 10408029 | 16460 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 389 | 6 | 1 | 6 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2)CC1 | 10.1021/jm0009538 | |||
| CHEMBL123377 | 16460 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 389 | 6 | 1 | 6 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2)CC1 | 10.1021/jm0009538 | |||
| 10834000 | 16329 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 385 | 6 | 1 | 7 | 1.9 | CCOC(=O)N1CCN(CCOC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm0009538 | |||
| CHEMBL122818 | 16329 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 385 | 6 | 1 | 7 | 1.9 | CCOC(=O)N1CCN(CCOC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm0009538 | |||
| 10669143 | 114254 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 407 | 6 | 1 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccc(F)cc2)CC1 | 10.1021/jm0009538 | |||
| CHEMBL333028 | 114254 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 407 | 6 | 1 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccc(F)cc2)CC1 | 10.1021/jm0009538 | |||
| 10069545 | 56576 | 0 | None | -831 | 2 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 399 | 5 | 2 | 4 | 3.9 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2Cc1ccccc1 | 10.1016/0960-894X(95)00115-A | |||
| CHEMBL164169 | 56576 | 0 | None | -831 | 2 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 399 | 5 | 2 | 4 | 3.9 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2Cc1ccccc1 | 10.1016/0960-894X(95)00115-A | |||
| 136118646 | 76319 | 0 | None | -2 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 335 | 1 | 2 | 3 | 3.1 | CSC1=NC(=O)/C(=C/c2c[nH]c3c(Br)cccc23)N1 | 10.1016/j.bmc.2013.09.011 | |||
| CHEMBL2058701 | 76319 | 0 | None | -2 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 335 | 1 | 2 | 3 | 3.1 | CSC1=NC(=O)/C(=C/c2c[nH]c3c(Br)cccc23)N1 | 10.1016/j.bmc.2013.09.011 | |||
| 136118635 | 76312 | 0 | None | -6 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 321 | 1 | 3 | 2 | 2.3 | O=C1NC(=S)N/C1=C\c1c[nH]c2cccc(Br)c12 | 10.1016/j.bmc.2013.09.011 | |||
| CHEMBL2058694 | 76312 | 0 | None | -6 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 321 | 1 | 3 | 2 | 2.3 | O=C1NC(=S)N/C1=C\c1c[nH]c2cccc(Br)c12 | 10.1016/j.bmc.2013.09.011 | |||
| 11549456 | 79052 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 736 | 15 | 4 | 12 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| CHEMBL2113157 | 79052 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 736 | 15 | 4 | 12 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| 11146533 | 107051 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 616 | 13 | 2 | 8 | 5.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | |||
| CHEMBL315590 | 107051 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 616 | 13 | 2 | 8 | 5.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | |||
| 15544722 | 207548 | 1 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 315 | 6 | 1 | 4 | 3.2 | CCCCN1CCC(COC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL94756 | 207548 | 1 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 315 | 6 | 1 | 4 | 3.2 | CCCCN1CCC(COC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 15544722 | 207548 | 1 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 315 | 6 | 1 | 4 | 3.2 | CCCCN1CCC(COC(=O)c2cccc3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| CHEMBL94756 | 207548 | 1 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 315 | 6 | 1 | 4 | 3.2 | CCCCN1CCC(COC(=O)c2cccc3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| 15544722 | 207548 | 1 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 315 | 6 | 1 | 4 | 3.2 | CCCCN1CCC(COC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL94756 | 207548 | 1 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 315 | 6 | 1 | 4 | 3.2 | CCCCN1CCC(COC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 10811181 | 163495 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 403 | 7 | 1 | 6 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(Cc2ccccc2)CC1 | 10.1021/jm0009538 | |||
| CHEMBL420166 | 163495 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 403 | 7 | 1 | 6 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(Cc2ccccc2)CC1 | 10.1021/jm0009538 | |||
| 9947817 | 5047 | 0 | None | -436 | 9 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 286 | 3 | 2 | 3 | 2.7 | CCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| CHEMBL105261 | 5047 | 0 | None | -436 | 9 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 286 | 3 | 2 | 3 | 2.7 | CCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| 107 | 141 | 121 | None | -389 | 30 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10.1016/j.ejmech.2009.01.015 | |||
| 1833 | 141 | 121 | None | -389 | 30 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10.1016/j.ejmech.2009.01.015 | |||
| CHEMBL8165 | 141 | 121 | None | -389 | 30 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10.1016/j.ejmech.2009.01.015 | |||
| 5 | 139 | 72 | None | -288 | 54 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2019.111596 | |||
| 5202 | 139 | 72 | None | -288 | 54 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2019.111596 | |||
| CHEMBL39 | 139 | 72 | None | -288 | 54 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2019.111596 | |||
| DB08839 | 139 | 72 | None | -288 | 54 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2019.111596 | |||
| 155559813 | 174839 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 338 | 6 | 1 | 2 | 5.0 | O=C(CCC1CCN(CC2CCCC2)CC1)c1ccc2[nH]ccc2c1 | 10.1016/j.ejmech.2018.10.064 | |||
| CHEMBL4562793 | 174839 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 338 | 6 | 1 | 2 | 5.0 | O=C(CCC1CCN(CC2CCCC2)CC1)c1ccc2[nH]ccc2c1 | 10.1016/j.ejmech.2018.10.064 | |||
| 10569278 | 187250 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 341 | 5 | 2 | 5 | 3.2 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCC(C)CC1 | 10.1021/jm960853v | |||
| CHEMBL49266 | 187250 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 341 | 5 | 2 | 5 | 3.2 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCC(C)CC1 | 10.1021/jm960853v | |||
| 70695322 | 77502 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 469 | 7 | 4 | 6 | 1.6 | CNC(=O)NCC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | |||
| CHEMBL2087328 | 77502 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 469 | 7 | 4 | 6 | 1.6 | CNC(=O)NCC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | |||
| 6604789 | 101047 | 5 | None | 12 | 10 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 311 | 3 | 1 | 4 | 1.6 | Cn1cc(C(=O)C(=O)N[C@H]2CN3CCC2CC3)c2ccccc21 | 10.1016/0960-894X(95)00308-G | |||
| CHEMBL294649 | 101047 | 5 | None | 12 | 10 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 311 | 3 | 1 | 4 | 1.6 | Cn1cc(C(=O)C(=O)N[C@H]2CN3CCC2CC3)c2ccccc21 | 10.1016/0960-894X(95)00308-G | |||
| 71712613 | 91379 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 464 | 7 | 3 | 7 | -0.3 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(NC(=O)c3cccc4[nH]cnc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | |||
| CHEMBL2402889 | 91379 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 464 | 7 | 3 | 7 | -0.3 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(NC(=O)c3cccc4[nH]cnc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | |||
| 44248793 91900478 | 195623 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 339 | 3 | 2 | 4 | 2.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL556235 | 195623 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 339 | 3 | 2 | 4 | 2.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)cc2ccccc21 | 10.1021/jm900881j | |||
| 44249053 | 196501 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 394 | 6 | 2 | 5 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN2CCCCC2)CC1 | 10.1021/jm900881j | |||
| CHEMBL563445 | 196501 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 394 | 6 | 2 | 5 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN2CCCCC2)CC1 | 10.1021/jm900881j | |||
| 6918647 | 100746 | 2 | None | -501 | 14 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 439 | 5 | 1 | 5 | 3.0 | COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1 | 10.1021/jm980532e | |||
| CHEMBL292759 | 100746 | 2 | None | -501 | 14 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 439 | 5 | 1 | 5 | 3.0 | COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1 | 10.1021/jm980532e | |||
| 44247945 | 196070 | 0 | None | - | 1 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 391 | 6 | 3 | 6 | 1.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCS(=O)(=O)O)CC1 | 10.1021/jm900881j | |||
| CHEMBL560597 | 196070 | 0 | None | - | 1 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 391 | 6 | 3 | 6 | 1.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCS(=O)(=O)O)CC1 | 10.1021/jm900881j | |||
| 131725 | 200437 | 3 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 342 | 2 | 1 | 5 | 2.6 | CC(C)n1c(=O)n(C(=O)NC2CC3CCC(C2)N3C)c2ccccc21 | 10.1021/jm960320m | |||
| CHEMBL59834 | 200437 | 3 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 342 | 2 | 1 | 5 | 2.6 | CC(C)n1c(=O)n(C(=O)NC2CC3CCC(C2)N3C)c2ccccc21 | 10.1021/jm960320m | |||
| 15544723 | 207436 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 380 | 7 | 2 | 6 | 1.0 | CS(=O)(=O)NCCN1CCC(COC(=O)c2cccc3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| CHEMBL94099 | 207436 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 380 | 7 | 2 | 6 | 1.0 | CS(=O)(=O)NCCN1CCC(COC(=O)c2cccc3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| 15544723 | 207436 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 380 | 7 | 2 | 6 | 1.0 | CS(=O)(=O)NCCN1CCC(COC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL94099 | 207436 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 380 | 7 | 2 | 6 | 1.0 | CS(=O)(=O)NCCN1CCC(COC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 15544723 | 207436 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 380 | 7 | 2 | 6 | 1.0 | CS(=O)(=O)NCCN1CCC(COC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL94099 | 207436 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 380 | 7 | 2 | 6 | 1.0 | CS(=O)(=O)NCCN1CCC(COC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 107 | 141 | 121 | None | -389 | 30 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10.1016/j.ejmech.2009.01.015 | |||
| 1833 | 141 | 121 | None | -389 | 30 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10.1016/j.ejmech.2009.01.015 | |||
| CHEMBL8165 | 141 | 121 | None | -389 | 30 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10.1016/j.ejmech.2009.01.015 | |||
| 10897011 | 168165 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 560 | 9 | 2 | 8 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | |||
| CHEMBL433149 | 168165 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 560 | 9 | 2 | 8 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | |||
| 11825705 | 108208 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 407 | 6 | 3 | 4 | 3.2 | CCCCN1CCC(CNC(=O)c2cc(Br)c(N)c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL319663 | 108208 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 407 | 6 | 3 | 4 | 3.2 | CCCCN1CCC(CNC(=O)c2cc(Br)c(N)c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 11825705 | 108208 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 407 | 6 | 3 | 4 | 3.2 | CCCCN1CCC(CNC(=O)c2cc(Br)c(N)c3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| CHEMBL319663 | 108208 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 407 | 6 | 3 | 4 | 3.2 | CCCCN1CCC(CNC(=O)c2cc(Br)c(N)c3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| 11825705 | 108208 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 407 | 6 | 3 | 4 | 3.2 | CCCCN1CCC(CNC(=O)c2cc(Br)c(N)c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL319663 | 108208 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 407 | 6 | 3 | 4 | 3.2 | CCCCN1CCC(CNC(=O)c2cc(Br)c(N)c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 850953 | 38411 | 2 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 348 | 2 | 2 | 3 | 2.1 | O=C(N[C@H]1CN2CCC1CC2)c1cc(Br)cc2nc[nH]c12 | 10.1021/jm991076c | |||
| CHEMBL146368 | 38411 | 2 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 348 | 2 | 2 | 3 | 2.1 | O=C(N[C@H]1CN2CCC1CC2)c1cc(Br)cc2nc[nH]c12 | 10.1021/jm991076c | |||
| 182593 | 3395 | 6 | None | -2 | 2 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1021/jm960320m | |||
| 254 | 3395 | 6 | None | -2 | 2 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1021/jm960320m | |||
| CHEMBL83954 | 3395 | 6 | None | -2 | 2 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1021/jm960320m | |||
| 10425296 | 163399 | 0 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 306 | 2 | 1 | 3 | 2.1 | O=C(N[C@H]1CN2CCC1CC2)c1cc(Cl)cc2c1OCC2 | 10.1016/0960-894X(96)00002-9 | |||
| CHEMBL419496 | 163399 | 0 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 306 | 2 | 1 | 3 | 2.1 | O=C(N[C@H]1CN2CCC1CC2)c1cc(Cl)cc2c1OCC2 | 10.1016/0960-894X(96)00002-9 | |||
| 44327605 | 207491 | 3 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 300 | 5 | 2 | 3 | 2.6 | CCCCN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL94415 | 207491 | 3 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 300 | 5 | 2 | 3 | 2.6 | CCCCN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 240 | 944 | 43 | None | -11 | 24 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0205651 | |||
| 2769 | 944 | 43 | None | -11 | 24 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0205651 | |||
| 44279790 | 944 | 43 | None | -11 | 24 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0205651 | |||
| 660 | 944 | 43 | None | -11 | 24 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0205651 | |||
| CHEMBL1729 | 944 | 43 | None | -11 | 24 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0205651 | |||
| CHEMBL560739 | 944 | 43 | None | -11 | 24 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0205651 | |||
| DB00604 | 944 | 43 | None | -11 | 24 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0205651 | |||
| 5 | 139 | 72 | None | -288 | 54 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2009.01.015 | |||
| 5202 | 139 | 72 | None | -288 | 54 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2009.01.015 | |||
| CHEMBL39 | 139 | 72 | None | -288 | 54 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2009.01.015 | |||
| DB08839 | 139 | 72 | None | -288 | 54 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2009.01.015 | |||
| 11724799 | 10532 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 339 | 0 | 2 | 5 | 1.5 | Nc1cc2c(cc1Cl)C(=O)NC1CCN(CCOCCO2)CC1 | 10.1016/0960-894X(95)00115-A | |||
| CHEMBL116913 | 10532 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 339 | 0 | 2 | 5 | 1.5 | Nc1cc2c(cc1Cl)C(=O)NC1CCN(CCOCCO2)CC1 | 10.1016/0960-894X(95)00115-A | |||
| 44327605 | 207491 | 3 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 300 | 5 | 2 | 3 | 2.6 | CCCCN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| CHEMBL94415 | 207491 | 3 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 300 | 5 | 2 | 3 | 2.6 | CCCCN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| 44327605 | 207491 | 3 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 300 | 5 | 2 | 3 | 2.6 | CCCCN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL94415 | 207491 | 3 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 300 | 5 | 2 | 3 | 2.6 | CCCCN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 10550242 | 17257 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2Cl)CC1 | 10.1021/jm0009538 | |||
| CHEMBL125670 | 17257 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2Cl)CC1 | 10.1021/jm0009538 | |||
| 11629268 | 72277 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 824 | 21 | 4 | 14 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCOCCOCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| CHEMBL198271 | 72277 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 824 | 21 | 4 | 14 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCOCCOCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| 11796362 | 115101 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 419 | 7 | 1 | 7 | 2.9 | COc1cccc(N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)c1 | 10.1021/jm0009538 | |||
| CHEMBL334325 | 115101 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 419 | 7 | 1 | 7 | 2.9 | COc1cccc(N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)c1 | 10.1021/jm0009538 | |||
| 71461050 | 82977 | 0 | None | 13 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 352 | 5 | 0 | 3 | 5.0 | CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1 | 10.1016/j.bmc.2013.08.061 | |||
| CHEMBL2181189 | 82977 | 0 | None | 13 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 352 | 5 | 0 | 3 | 5.0 | CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1 | 10.1016/j.bmc.2013.08.061 | |||
| 71461050 | 82977 | 0 | None | 13 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 352 | 5 | 0 | 3 | 5.0 | CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | |||
| CHEMBL2181189 | 82977 | 0 | None | 13 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 352 | 5 | 0 | 3 | 5.0 | CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | |||
| 44247820 91900493 | 194799 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 534 | 12 | 1 | 5 | 6.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL538706 | 194799 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 534 | 12 | 1 | 5 | 6.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | |||
| 44248435 | 195580 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 623 | 15 | 2 | 5 | 7.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN(C)CCc2c[nH]c3ccccc23)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL555210 | 195580 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 623 | 15 | 2 | 5 | 7.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN(C)CCc2c[nH]c3ccccc23)cc2ccccc21 | 10.1021/jm900881j | |||
| 44247953 | 195818 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 581 | 12 | 2 | 5 | 6.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN(C)CCc2c[nH]c3ccccc23)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL558163 | 195818 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 581 | 12 | 2 | 5 | 6.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN(C)CCc2c[nH]c3ccccc23)cc2ccccc21 | 10.1021/jm900881j | |||
| 44249183 | 196380 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 478 | 12 | 2 | 5 | 5.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN2CCCCC2)CC1 | 10.1021/jm900881j | |||
| CHEMBL562636 | 196380 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 478 | 12 | 2 | 5 | 5.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN2CCCCC2)CC1 | 10.1021/jm900881j | |||
| 235 | 2564 | 42 | None | -4 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm070552t | |||
| 5311299 | 2564 | 42 | None | -4 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm070552t | |||
| CHEMBL286136 | 2564 | 42 | None | -4 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm070552t | |||
| 9800656 | 15550 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | |||
| CHEMBL121913 | 15550 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | |||
| 10715463 | 16351 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 390 | 6 | 1 | 7 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccncc2)CC1 | 10.1021/jm0009538 | |||
| CHEMBL122914 | 16351 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 390 | 6 | 1 | 7 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccncc2)CC1 | 10.1021/jm0009538 | |||
| 71462652 | 82683 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 434 | 8 | 2 | 8 | 2.6 | CC(C)(O)COc1cccc2onc(OCC3CCN(CC4(O)CCOCC4)CC3)c12 | 10.1021/jm300953p | |||
| CHEMBL2179590 | 82683 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 434 | 8 | 2 | 8 | 2.6 | CC(C)(O)COc1cccc2onc(OCC3CCN(CC4(O)CCOCC4)CC3)c12 | 10.1021/jm300953p | |||
| 235 | 2564 | 42 | None | -4 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | |||
| 5311299 | 2564 | 42 | None | -4 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | |||
| CHEMBL286136 | 2564 | 42 | None | -4 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | |||
| 5145950 | 203487 | 7 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 553 | 13 | 2 | 8 | 3.7 | COc1cc(COc2cc(N)c(Cl)cc2C(=O)CCC2CCN(CCNS(C)(=O)=O)CC2)cc(OC)c1 | 10.1021/jm400766k | |||
| CHEMBL586946 | 203487 | 7 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 553 | 13 | 2 | 8 | 3.7 | COc1cc(COc2cc(N)c(Cl)cc2C(=O)CCC2CCN(CCNS(C)(=O)=O)CC2)cc(OC)c1 | 10.1021/jm400766k | |||
| CHEMBL66114 | 203487 | 7 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 553 | 13 | 2 | 8 | 3.7 | COc1cc(COc2cc(N)c(Cl)cc2C(=O)CCC2CCN(CCNS(C)(=O)=O)CC2)cc(OC)c1 | 10.1021/jm400766k | |||
| 71451950 | 82675 | 8 | None | 1 | 2 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | |||
| CHEMBL2179582 | 82675 | 8 | None | 1 | 2 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | |||
| 135409453 | 3773 | 41 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmc.2008.11.045 | |||
| 226 | 3773 | 41 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmc.2008.11.045 | |||
| CHEMBL76370 | 3773 | 41 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmc.2008.11.045 | |||
| 135409453 | 3773 | 41 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2013.05.018 | |||
| 226 | 3773 | 41 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2013.05.018 | |||
| CHEMBL76370 | 3773 | 41 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2013.05.018 | |||
| 71712464 | 91391 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 445 | 8 | 3 | 6 | 2.2 | COC(=O)N(C)CC(O)CN1CCC(CNC(=O)c2cccc3[nH]c(C(C)C)nc23)CC1 | 10.1016/j.bmcl.2013.05.018 | |||
| CHEMBL2402901 | 91391 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 445 | 8 | 3 | 6 | 2.2 | COC(=O)N(C)CC(O)CN1CCC(CNC(=O)c2cccc3[nH]c(C(C)C)nc23)CC1 | 10.1016/j.bmcl.2013.05.018 | |||
| 71712465 | 91392 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 429 | 8 | 3 | 5 | 2.0 | CC(=O)N(C)CC(O)CN1CCC(CNC(=O)c2cccc3[nH]c(C(C)C)nc23)CC1 | 10.1016/j.bmcl.2013.05.018 | |||
| CHEMBL2402902 | 91392 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 429 | 8 | 3 | 5 | 2.0 | CC(=O)N(C)CC(O)CN1CCC(CNC(=O)c2cccc3[nH]c(C(C)C)nc23)CC1 | 10.1016/j.bmcl.2013.05.018 | |||
| 72697299 | 92874 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 547 | 7 | 2 | 7 | 4.9 | O=C(NCC1CCN(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)CC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmc.2013.09.004 | |||
| CHEMBL2440455 | 92874 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 547 | 7 | 2 | 7 | 4.9 | O=C(NCC1CCN(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)CC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmc.2013.09.004 | |||
| 135409453 | 3773 | 41 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.05.034 | |||
| 226 | 3773 | 41 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.05.034 | |||
| CHEMBL76370 | 3773 | 41 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.05.034 | |||
| 70688534 | 76413 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 441 | 8 | 2 | 6 | 3.0 | CC(C)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | |||
| CHEMBL2059579 | 76413 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 441 | 8 | 2 | 6 | 3.0 | CC(C)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | |||
| 11677434 | 76415 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 483 | 9 | 2 | 7 | 2.8 | COC[C@@H]1CCCN1CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | |||
| CHEMBL2059581 | 76415 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 483 | 9 | 2 | 7 | 2.8 | COC[C@@H]1CCCN1CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | |||
| 11606227 | 76419 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 532 | 8 | 2 | 8 | 1.3 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | |||
| CHEMBL2059585 | 76419 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 532 | 8 | 2 | 8 | 1.3 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | |||
| 135409453 | 3773 | 41 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.08.051 | |||
| 226 | 3773 | 41 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.08.051 | |||
| CHEMBL76370 | 3773 | 41 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.08.051 | |||
| 44248437 | 194836 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 597 | 12 | 1 | 6 | 6.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCN(c3ccccc3)CC2)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL539651 | 194836 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 597 | 12 | 1 | 6 | 6.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCN(c3ccccc3)CC2)cc2ccccc21 | 10.1021/jm900881j | |||
| 11714709 | 79053 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 750 | 16 | 4 | 12 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| CHEMBL2113158 | 79053 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 750 | 16 | 4 | 12 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| 11039730 | 206248 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 687 | 16 | 2 | 9 | 4.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CCCCCCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | |||
| CHEMBL86777 | 206248 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 687 | 16 | 2 | 9 | 4.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CCCCCCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | |||
| 135409453 | 3773 | 41 | None | -2 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1021/np0601760 | |||
| 226 | 3773 | 41 | None | -2 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1021/np0601760 | |||
| CHEMBL76370 | 3773 | 41 | None | -2 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1021/np0601760 | |||
| 182593 | 3395 | 6 | None | 2 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1016/j.bmc.2008.11.045 | |||
| 254 | 3395 | 6 | None | 2 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1016/j.bmc.2008.11.045 | |||
| CHEMBL83954 | 3395 | 6 | None | 2 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1016/j.bmc.2008.11.045 | |||
| 71459132 | 84567 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 419 | 7 | 1 | 3 | 4.4 | CC(C)n1nc(C(=O)NCC2CC[N+](C)(CCc3ccccc3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| CHEMBL2179698 | 84567 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 419 | 7 | 1 | 3 | 4.4 | CC(C)n1nc(C(=O)NCC2CC[N+](C)(CCc3ccccc3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| CHEMBL2220893 | 84567 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 419 | 7 | 1 | 3 | 4.4 | CC(C)n1nc(C(=O)NCC2CC[N+](C)(CCc3ccccc3)CC2)c2ccccc21 | 10.1021/jm300573d | |||
| 67276466 | 77498 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 454 | 7 | 3 | 6 | 1.8 | CC(=O)NCC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | |||
| CHEMBL2087324 | 77498 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 454 | 7 | 3 | 6 | 1.8 | CC(=O)NCC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | |||
| 44248311 91900487 | 195630 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 596 | 12 | 1 | 6 | 5.9 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN2C(=O)c3ccccc3C2=O)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL556279 | 195630 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 596 | 12 | 1 | 6 | 5.9 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN2C(=O)c3ccccc3C2=O)cc2ccccc21 | 10.1021/jm900881j | |||
| 39736 | 184232 | 8 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 248 | 4 | 1 | 3 | 2.7 | O=C(Nc1ccccc1)OCCN1CCCCC1 | 10.1021/jm960853v | |||
| CHEMBL48351 | 184232 | 8 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 248 | 4 | 1 | 3 | 2.7 | O=C(Nc1ccccc1)OCCN1CCCCC1 | 10.1021/jm960853v | |||
| 71712612 | 91378 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 490 | 7 | 3 | 7 | 0.2 | CS(=O)(=O)N1CCN(CC(O)CN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2cccc4[nH]cnc24)C3)CC1 | 10.1016/j.bmcl.2013.05.018 | |||
| CHEMBL2402888 | 91378 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 490 | 7 | 3 | 7 | 0.2 | CS(=O)(=O)N1CCN(CC(O)CN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2cccc4[nH]cnc24)C3)CC1 | 10.1016/j.bmcl.2013.05.018 | |||
| 9817713 | 194837 | 61 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 297 | 4 | 3 | 4 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCNCC1 | 10.1021/jm900881j | |||
| CHEMBL539652 | 194837 | 61 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 297 | 4 | 3 | 4 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCNCC1 | 10.1021/jm900881j | |||
| 44249316 91900479 | 195352 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 328 | 2 | 2 | 5 | 2.2 | CC(C)n1c(=O)n(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)c2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL551820 | 195352 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 328 | 2 | 2 | 5 | 2.2 | CC(C)n1c(=O)n(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)c2ccccc21 | 10.1021/jm900881j | |||
| 44248796 | 195516 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 302 | 5 | 3 | 4 | 0.8 | COc1ccc2[nH]cc(C(=O)NCCN3CCNCC3)c2c1 | 10.1021/jm900881j | |||
| CHEMBL553688 | 195516 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 302 | 5 | 3 | 4 | 0.8 | COc1ccc2[nH]cc(C(=O)NCCN3CCNCC3)c2c1 | 10.1021/jm900881j | |||
| 10346043 | 47120 | 0 | None | -3162 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 503 | 5 | 2 | 5 | 3.4 | COc1ccc(S(=O)(=O)Nc2cc(Br)ccc2Br)cc1N1CCNCC1 | 10.1016/s0960-894x(00)00597-7 | |||
| CHEMBL154274 | 47120 | 0 | None | -3162 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 503 | 5 | 2 | 5 | 3.4 | COc1ccc(S(=O)(=O)Nc2cc(Br)ccc2Br)cc1N1CCNCC1 | 10.1016/s0960-894x(00)00597-7 | |||
| 6918648 | 101559 | 1 | None | -5128 | 14 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 465 | 5 | 1 | 6 | 4.4 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 | 10.1021/jm980532e | |||
| CHEMBL29846 | 101559 | 1 | None | -5128 | 14 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 465 | 5 | 1 | 6 | 4.4 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 | 10.1021/jm980532e | |||
| 44249311 | 195326 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 313 | 3 | 2 | 4 | 2.1 | CC(C)n1c(=O)c(C(=O)NC2CCNCC2)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL551614 | 195326 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 313 | 3 | 2 | 4 | 2.1 | CC(C)n1c(=O)c(C(=O)NC2CCNCC2)cc2ccccc21 | 10.1021/jm900881j | |||
| 44249317 91900480 | 195341 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 299 | 3 | 3 | 3 | 2.2 | COc1ccc2[nH]cc(C(=O)N[C@@H]3C[C@@H]4CC[C@H](C3)N4)c2c1 | 10.1021/jm900881j | |||
| CHEMBL551743 | 195341 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 299 | 3 | 3 | 3 | 2.2 | COc1ccc2[nH]cc(C(=O)N[C@@H]3C[C@@H]4CC[C@H](C3)N4)c2c1 | 10.1021/jm900881j | |||
| 44249318 | 195868 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 273 | 3 | 3 | 3 | 1.7 | COc1ccc2[nH]cc(C(=O)NC3CCNCC3)c2c1 | 10.1021/jm900881j | |||
| CHEMBL558757 | 195868 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 273 | 3 | 3 | 3 | 1.7 | COc1ccc2[nH]cc(C(=O)NC3CCNCC3)c2c1 | 10.1021/jm900881j | |||
| 6918648 | 101559 | 1 | None | -5128 | 14 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 465 | 5 | 1 | 6 | 4.4 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 | 10.1016/s0960-894x(02)00172-5 | |||
| CHEMBL29846 | 101559 | 1 | None | -5128 | 14 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 465 | 5 | 1 | 6 | 4.4 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 | 10.1016/s0960-894x(02)00172-5 | |||
| 11841877 | 39848 | 1 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 318 | 2 | 2 | 3 | 2.6 | CN1C2CCC1CC(NC(=O)c1cc(Cl)cc3[nH]cnc13)C2 | 10.1021/jm991076c | |||
| CHEMBL147725 | 39848 | 1 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 318 | 2 | 2 | 3 | 2.6 | CN1C2CCC1CC(NC(=O)c1cc(Cl)cc3[nH]cnc13)C2 | 10.1021/jm991076c | |||
| 11093246 | 111545 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 602 | 12 | 2 | 8 | 4.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | |||
| CHEMBL327999 | 111545 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 602 | 12 | 2 | 8 | 4.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | |||
| 10408029 | 16460 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 389 | 6 | 1 | 6 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2)CC1 | 10.1021/jm0009538 | |||
| CHEMBL123377 | 16460 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 389 | 6 | 1 | 6 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2)CC1 | 10.1021/jm0009538 | |||
| 49783206 | 17577 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 373 | 6 | 1 | 7 | 2.6 | CCCCN1CCC(COC(=O)c2cc(C#N)c(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | |||
| CHEMBL1258108 | 17577 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 373 | 6 | 1 | 7 | 2.6 | CCCCN1CCC(COC(=O)c2cc(C#N)c(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | |||
| 71461048 | 82973 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 352 | 5 | 0 | 3 | 5.0 | CCCN1CCC(COc2nc3cc(F)ccc3c3ccccc23)CC1 | 10.1021/jm300943r | |||
| CHEMBL2181185 | 82973 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 352 | 5 | 0 | 3 | 5.0 | CCCN1CCC(COc2nc3cc(F)ccc3c3ccccc23)CC1 | 10.1021/jm300943r | |||
| 44281491 | 112474 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 312 | 4 | 1 | 5 | 2.6 | CCN1CCCC(OC(=O)c2cc(Cl)c(N)cc2OC)C1 | 10.1016/S0960-894X(01)80508-4 | |||
| CHEMBL32986 | 112474 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 312 | 4 | 1 | 5 | 2.6 | CCN1CCCC(OC(=O)c2cc(Cl)c(N)cc2OC)C1 | 10.1016/S0960-894X(01)80508-4 | |||
| 10018558 | 50751 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 314 | 5 | 1 | 6 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCOCC1 | 10.1021/jm960320m | |||
| CHEMBL157631 | 50751 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 314 | 5 | 1 | 6 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCOCC1 | 10.1021/jm960320m | |||
| 44364334 | 39956 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 319 | 2 | 1 | 4 | 3.0 | CN1C2CCC1CC(OC(=O)c1cc(Cl)cc3[nH]cnc13)C2 | 10.1021/jm991076c | |||
| CHEMBL147827 | 39956 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 319 | 2 | 1 | 4 | 3.0 | CN1C2CCC1CC(OC(=O)c1cc(Cl)cc3[nH]cnc13)C2 | 10.1021/jm991076c | |||
| 54677674 | 112809 | 4 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1016/j.ejmech.2014.05.015 | |||
| CHEMBL3291085 | 112809 | 4 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1016/j.ejmech.2014.05.015 | |||
| CHEMBL3306918 | 112809 | 4 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1016/j.ejmech.2014.05.015 | |||
| 11498641 | 79054 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 736 | 15 | 4 | 12 | 2.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| CHEMBL2113159 | 79054 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 736 | 15 | 4 | 12 | 2.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| 49783212 | 17676 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 387 | 7 | 1 | 7 | 3.0 | CCCCN1CCC(COC(=O)c2cc(C#N)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | |||
| CHEMBL1258450 | 17676 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 387 | 7 | 1 | 7 | 3.0 | CCCCN1CCC(COC(=O)c2cc(C#N)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | |||
| 5 | 139 | 72 | None | -117 | 54 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/0960-894X(96)00002-9 | |||
| 5202 | 139 | 72 | None | -117 | 54 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/0960-894X(96)00002-9 | |||
| CHEMBL39 | 139 | 72 | None | -117 | 54 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/0960-894X(96)00002-9 | |||
| DB08839 | 139 | 72 | None | -117 | 54 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/0960-894X(96)00002-9 | |||
| 155517675 | 170189 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 386 | 6 | 1 | 2 | 6.1 | O=C(CCC1CCN(CC2CCCCC2)CC1)c1cc(Cl)c2[nH]ccc2c1 | 10.1016/j.ejmech.2018.10.064 | |||
| CHEMBL4444843 | 170189 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 386 | 6 | 1 | 2 | 6.1 | O=C(CCC1CCN(CC2CCCCC2)CC1)c1cc(Cl)c2[nH]ccc2c1 | 10.1016/j.ejmech.2018.10.064 | |||
| 155545651 | 173464 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 352 | 6 | 1 | 2 | 5.4 | O=C(CCC1CCN(CC2CCCCC2)CC1)c1ccc2[nH]ccc2c1 | 10.1016/j.ejmech.2018.10.064 | |||
| CHEMBL4529710 | 173464 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 352 | 6 | 1 | 2 | 5.4 | O=C(CCC1CCN(CC2CCCCC2)CC1)c1ccc2[nH]ccc2c1 | 10.1016/j.ejmech.2018.10.064 | |||
| 146025727 | 171685 | 0 | None | -138 | 27 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 411 | 3 | 0 | 5 | 6.4 | FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12 | 10.1021/acs.jmedchem.9b00351 | |||
| CHEMBL4466483 | 171685 | 0 | None | -138 | 27 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 411 | 3 | 0 | 5 | 6.4 | FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12 | 10.1021/acs.jmedchem.9b00351 | |||
| 136118639 | 76317 | 0 | None | -2 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 335 | 1 | 2 | 3 | 3.1 | CSC1=NC(=O)/C(=C/c2c[nH]c3ccc(Br)cc23)N1 | 10.1016/j.bmc.2013.09.011 | |||
| CHEMBL2058699 | 76317 | 0 | None | -2 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 335 | 1 | 2 | 3 | 3.1 | CSC1=NC(=O)/C(=C/c2c[nH]c3ccc(Br)cc23)N1 | 10.1016/j.bmc.2013.09.011 | |||
| 850954 | 40256 | 2 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 348 | 2 | 2 | 3 | 2.1 | O=C(N[C@@H]1CN2CCC1CC2)c1cc(Br)cc2nc[nH]c12 | 10.1021/jm991076c | |||
| CHEMBL148080 | 40256 | 2 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 348 | 2 | 2 | 3 | 2.1 | O=C(N[C@@H]1CN2CCC1CC2)c1cc(Br)cc2nc[nH]c12 | 10.1021/jm991076c | |||
| 44352308 | 117487 | 0 | None | -46 | 12 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 339 | 5 | 2 | 2 | 4.0 | Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C | 10.1021/jm0155190 | |||
| CHEMBL339980 | 117487 | 0 | None | -46 | 12 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 339 | 5 | 2 | 2 | 4.0 | Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C | 10.1021/jm0155190 | |||
| 6604914 | 100384 | 3 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1016/0960-894X(95)00115-A | |||
| CHEMBL28992 | 100384 | 3 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1016/0960-894X(95)00115-A | |||
| 6604914 | 100384 | 3 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1021/jm960320m | |||
| CHEMBL28992 | 100384 | 3 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1021/jm960320m | |||
| 10568248 | 185978 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 327 | 5 | 2 | 5 | 3.0 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCCCC1 | 10.1021/jm960853v | |||
| CHEMBL48698 | 185978 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 327 | 5 | 2 | 5 | 3.0 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCCCC1 | 10.1021/jm960853v | |||
| 10545158 | 50356 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 340 | 5 | 1 | 5 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1C(C)CCCC1C | 10.1021/jm960320m | |||
| CHEMBL157233 | 50356 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 340 | 5 | 1 | 5 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1C(C)CCCC1C | 10.1021/jm960320m | |||
| 67276147 | 77499 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 468 | 7 | 2 | 6 | 2.1 | CC(=O)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | |||
| CHEMBL2087325 | 77499 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 468 | 7 | 2 | 6 | 2.1 | CC(=O)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | |||
| 70684790 | 77507 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 484 | 7 | 2 | 7 | 2.4 | COC(=O)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | |||
| CHEMBL2087333 | 77507 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 484 | 7 | 2 | 7 | 2.4 | COC(=O)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | |||
| 44248191 | 194899 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 537 | 8 | 1 | 7 | 3.5 | CCOC(=O)N1CCN(CCCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2cc4ccccc4n(C(C)C)c2=O)C3)CC1 | 10.1021/jm900881j | |||
| CHEMBL540980 | 194899 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 537 | 8 | 1 | 7 | 3.5 | CCOC(=O)N1CCN(CCCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2cc4ccccc4n(C(C)C)c2=O)C3)CC1 | 10.1021/jm900881j | |||
| 44247951 91900497 | 194912 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 539 | 9 | 2 | 5 | 5.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN(C)CCc2c[nH]c3ccccc23)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL541223 | 194912 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 539 | 9 | 2 | 5 | 5.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN(C)CCc2c[nH]c3ccccc23)cc2ccccc21 | 10.1021/jm900881j | |||
| 44248076 | 195044 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 543 | 8 | 1 | 7 | 2.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL549449 | 195044 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 543 | 8 | 1 | 7 | 2.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | |||
| 44248195 | 195082 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 466 | 7 | 1 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCOCC2)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL549650 | 195082 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 466 | 7 | 1 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCOCC2)cc2ccccc21 | 10.1021/jm900881j | |||
| 44248072 | 195675 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 483 | 9 | 3 | 5 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN(C)CCc2c[nH]c3ccccc23)CC1 | 10.1021/jm900881j | |||
| CHEMBL556595 | 195675 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 483 | 9 | 3 | 5 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN(C)CCc2c[nH]c3ccccc23)CC1 | 10.1021/jm900881j | |||
| 44248068 | 195885 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 515 | 10 | 2 | 7 | 1.9 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN2CCN(S(C)(=O)=O)CC2)CC1 | 10.1021/jm900881j | |||
| CHEMBL558924 | 195885 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 515 | 10 | 2 | 7 | 1.9 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN2CCN(S(C)(=O)=O)CC2)CC1 | 10.1021/jm900881j | |||
| 44247943 | 195948 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 540 | 12 | 2 | 6 | 4.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN2C(=O)c3ccccc3C2=O)CC1 | 10.1021/jm900881j | |||
| CHEMBL559548 | 195948 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 540 | 12 | 2 | 6 | 4.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN2C(=O)c3ccccc3C2=O)CC1 | 10.1021/jm900881j | |||
| 44249188 | 196112 | 1 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 316 | 3 | 2 | 5 | 1.9 | CC(C)n1c(=O)n(C(=O)NCC2CCNCC2)c2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL560940 | 196112 | 1 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 316 | 3 | 2 | 5 | 1.9 | CC(C)n1c(=O)n(C(=O)NCC2CCNCC2)c2ccccc21 | 10.1021/jm900881j | |||
| 10337773 | 101585 | 0 | None | 31 | 10 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 311 | 3 | 1 | 4 | 1.6 | Cn1cc(C(=O)C(=O)N[C@@H]2CN3CCC2CC3)c2ccccc21 | 10.1016/0960-894X(95)00308-G | |||
| CHEMBL298612 | 101585 | 0 | None | 31 | 10 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 311 | 3 | 1 | 4 | 1.6 | Cn1cc(C(=O)C(=O)N[C@@H]2CN3CCC2CC3)c2ccccc21 | 10.1016/0960-894X(95)00308-G | |||
| 67211178 | 82726 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 295 | 3 | 1 | 4 | 3.1 | Cn1cc2c(OCC3CCNCC3)nc3ccccc3c2c1 | 10.1021/jm300573d | |||
| CHEMBL2179680 | 82726 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 295 | 3 | 1 | 4 | 3.1 | Cn1cc2c(OCC3CCNCC3)nc3ccccc3c2c1 | 10.1021/jm300573d | |||
| 10493462 | 202487 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 286 | 3 | 2 | 4 | 2.1 | CC(C)n1nc(C(=O)NC2CCNCC2)c2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL61130 | 202487 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 286 | 3 | 2 | 4 | 2.1 | CC(C)n1nc(C(=O)NC2CCNCC2)c2ccccc21 | 10.1021/jm900881j | |||
| 10413595 | 161841 | 0 | None | -12589 | 11 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 499 | 4 | 1 | 5 | 2.5 | COc1ccc(S(=O)(=O)N2CCc3ccc(I)cc32)cc1N1CCNCC1 | 10.1016/s0960-894x(00)00597-7 | |||
| CHEMBL414628 | 161841 | 0 | None | -12589 | 11 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 499 | 4 | 1 | 5 | 2.5 | COc1ccc(S(=O)(=O)N2CCc3ccc(I)cc32)cc1N1CCNCC1 | 10.1016/s0960-894x(00)00597-7 | |||
| 276 | 3513 | 50 | None | -2691 | 13 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 451 | 5 | 2 | 6 | 4.1 | COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl | 10.1021/jm980532e | |||
| 5312149 | 3513 | 50 | None | -2691 | 13 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 451 | 5 | 2 | 6 | 4.1 | COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl | 10.1021/jm980532e | |||
| CHEMBL431298 | 3513 | 50 | None | -2691 | 13 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 451 | 5 | 2 | 6 | 4.1 | COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl | 10.1021/jm980532e | |||
| 44248795 | 197631 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 287 | 4 | 3 | 3 | 1.9 | COc1ccc2[nH]cc(C(=O)NCC3CCNCC3)c2c1 | 10.1021/jm900881j | |||
| CHEMBL570780 | 197631 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 287 | 4 | 3 | 3 | 1.9 | COc1ccc2[nH]cc(C(=O)NCC3CCNCC3)c2c1 | 10.1021/jm900881j | |||
| 276 | 3513 | 50 | None | -2691 | 13 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 451 | 5 | 2 | 6 | 4.1 | COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl | 10.1016/s0960-894x(02)00172-5 | |||
| 5312149 | 3513 | 50 | None | -2691 | 13 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 451 | 5 | 2 | 6 | 4.1 | COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl | 10.1016/s0960-894x(02)00172-5 | |||
| CHEMBL431298 | 3513 | 50 | None | -2691 | 13 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 451 | 5 | 2 | 6 | 4.1 | COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl | 10.1016/s0960-894x(02)00172-5 | |||
| 9973684 | 51474 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 326 | 5 | 1 | 5 | 2.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C)CC1 | 10.1021/jm960320m | |||
| CHEMBL158238 | 51474 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 326 | 5 | 1 | 5 | 2.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C)CC1 | 10.1021/jm960320m | |||
| 10519226 | 101987 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 312 | 5 | 1 | 4 | 3.4 | COc1ccc(Cl)cc1NC(=O)OCCN1CCCCC1 | 10.1021/jm960853v | |||
| CHEMBL301510 | 101987 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 312 | 5 | 1 | 4 | 3.4 | COc1ccc(Cl)cc1NC(=O)OCCN1CCCCC1 | 10.1021/jm960853v | |||
| 11166796 | 82676 | 0 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | |||
| CHEMBL2179583 | 82676 | 0 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | |||
| 44213661 | 207077 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 338 | 5 | 1 | 5 | 2.9 | Nc1c(Cl)cc(C(=O)OCCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | |||
| CHEMBL91842 | 207077 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 338 | 5 | 1 | 5 | 2.9 | Nc1c(Cl)cc(C(=O)OCCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | |||
| 53357016 | 82674 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 446 | 7 | 1 | 8 | 3.0 | OC1(CN2CCC(COc3noc4cccc(OC5CCOCC5)c34)CC2)CCOCC1 | 10.1021/jm300953p | |||
| CHEMBL2179581 | 82674 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 446 | 7 | 1 | 8 | 3.0 | OC1(CN2CCC(COc3noc4cccc(OC5CCOCC5)c34)CC2)CCOCC1 | 10.1021/jm300953p | |||
| 49783210 | 17639 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 440 | 7 | 1 | 6 | 3.9 | CCCCN1CCC(COC(=O)c2cc(Br)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | |||
| CHEMBL1258338 | 17639 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 440 | 7 | 1 | 6 | 3.9 | CCCCN1CCC(COC(=O)c2cc(Br)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | |||
| 71451950 | 82675 | 8 | None | -1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | |||
| CHEMBL2179582 | 82675 | 8 | None | -1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | |||
| 15295138 | 51062 | 0 | None | - | 1 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 328 | 5 | 2 | 6 | 1.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(O)C1 | 10.1021/jm960320m | |||
| CHEMBL157880 | 51062 | 0 | None | - | 1 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 328 | 5 | 2 | 6 | 1.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(O)C1 | 10.1021/jm960320m | |||
| 11166796 | 82676 | 0 | None | -2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | |||
| CHEMBL2179583 | 82676 | 0 | None | -2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | |||
| 134828071 | 173761 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 416 | 7 | 1 | 3 | 6.1 | COc1c(C(=O)CCC2CCN(CC3CCCCC3)CC2)cc(Cl)c2[nH]ccc12 | 10.1016/j.ejmech.2018.10.064 | |||
| CHEMBL4537101 | 173761 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 416 | 7 | 1 | 3 | 6.1 | COc1c(C(=O)CCC2CCN(CC3CCCCC3)CC2)cc(Cl)c2[nH]ccc12 | 10.1016/j.ejmech.2018.10.064 | |||
| 10020895 | 4705 | 0 | None | -524 | 8 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL103479 | 4705 | 0 | None | -524 | 8 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| 71452073 | 82966 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 335 | 5 | 0 | 4 | 4.3 | CCCN1CCC(COc2nc3ccccc3c3cnccc23)CC1 | 10.1021/jm300943r | |||
| CHEMBL2181172 | 82966 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 335 | 5 | 0 | 4 | 4.3 | CCCN1CCC(COc2nc3ccccc3c3cnccc23)CC1 | 10.1021/jm300943r | |||
| 44213663 | 206581 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | Nc1c(Cl)cc(C(=O)NCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | |||
| CHEMBL88867 | 206581 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | Nc1c(Cl)cc(C(=O)NCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | |||
| 44323269 | 12072 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 378 | 5 | 2 | 3 | 3.0 | CCCC[N+]12CCC(CC1)[C@@H](NC(=O)c1cc(Cl)c(N)c3c1OCC3)C2 | 10.1016/0960-894X(96)00002-9 | |||
| CHEMBL1183709 | 12072 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 378 | 5 | 2 | 3 | 3.0 | CCCC[N+]12CCC(CC1)[C@@H](NC(=O)c1cc(Cl)c(N)c3c1OCC3)C2 | 10.1016/0960-894X(96)00002-9 | |||
| CHEMBL314198 | 12072 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 378 | 5 | 2 | 3 | 3.0 | CCCC[N+]12CCC(CC1)[C@@H](NC(=O)c1cc(Cl)c(N)c3c1OCC3)C2 | 10.1016/0960-894X(96)00002-9 | |||
| 135446149 | 208185 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 393 | 7 | 2 | 5 | 3.4 | CCCCN1CCC(CNC(=O)c2cc(Cl)c([N+](=O)[O-])c3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| CHEMBL98397 | 208185 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 393 | 7 | 2 | 5 | 3.4 | CCCCN1CCC(CNC(=O)c2cc(Cl)c([N+](=O)[O-])c3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| 135446149 | 208185 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 393 | 7 | 2 | 5 | 3.4 | CCCCN1CCC(CNC(=O)c2cc(Cl)c([N+](=O)[O-])c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL98397 | 208185 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 393 | 7 | 2 | 5 | 3.4 | CCCCN1CCC(CNC(=O)c2cc(Cl)c([N+](=O)[O-])c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 135446149 | 208185 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 393 | 7 | 2 | 5 | 3.4 | CCCCN1CCC(CNC(=O)c2cc(Cl)c([N+](=O)[O-])c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL98397 | 208185 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 393 | 7 | 2 | 5 | 3.4 | CCCCN1CCC(CNC(=O)c2cc(Cl)c([N+](=O)[O-])c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 10566528 | 162140 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 305 | 2 | 1 | 4 | 2.5 | O=C(OC1CN2CCC1CC2)c1cc(Cl)cc2nc[nH]c12 | 10.1016/0960-894X(96)00200-4 | |||
| CHEMBL416172 | 162140 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 305 | 2 | 1 | 4 | 2.5 | O=C(OC1CN2CCC1CC2)c1cc(Cl)cc2nc[nH]c12 | 10.1016/0960-894X(96)00200-4 | |||
| 10566528 | 162140 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 305 | 2 | 1 | 4 | 2.5 | O=C(OC1CN2CCC1CC2)c1cc(Cl)cc2nc[nH]c12 | 10.1021/jm991076c | |||
| CHEMBL416172 | 162140 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 305 | 2 | 1 | 4 | 2.5 | O=C(OC1CN2CCC1CC2)c1cc(Cl)cc2nc[nH]c12 | 10.1021/jm991076c | |||
| 41581 | 189823 | 5 | None | - | 1 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 278 | 5 | 1 | 4 | 2.7 | COc1cccc(NC(=O)OCCN2CCCCC2)c1 | 10.1021/jm960853v | |||
| CHEMBL51647 | 189823 | 5 | None | - | 1 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 278 | 5 | 1 | 4 | 2.7 | COc1cccc(NC(=O)OCCN2CCCCC2)c1 | 10.1021/jm960853v | |||
| 44404969 | 72262 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 930 | 18 | 4 | 13 | 6.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCc2ccc3c(c2)oc2cc(CCC(=O)NC4CCN(CCOC(=O)c5cc(Cl)c(N)cc5OC)CC4)ccc23)CC1 | 10.1021/jm050234z | |||
| CHEMBL198226 | 72262 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 930 | 18 | 4 | 13 | 6.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCc2ccc3c(c2)oc2cc(CCC(=O)NC4CCN(CCOC(=O)c5cc(Cl)c(N)cc5OC)CC4)ccc23)CC1 | 10.1021/jm050234z | |||
| 10802184 | 54158 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 272 | 5 | 1 | 5 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN(C)C | 10.1021/jm960320m | |||
| CHEMBL160705 | 54158 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 272 | 5 | 1 | 5 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN(C)C | 10.1021/jm960320m | |||
| 135442121 | 112374 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 437 | 7 | 2 | 5 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(Br)c([N+](=O)[O-])c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL329545 | 112374 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 437 | 7 | 2 | 5 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(Br)c([N+](=O)[O-])c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 136118648 | 76321 | 0 | None | -9 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 318 | 1 | 3 | 2 | 2.0 | C/N=C1\NC(=O)/C(=C/c2c[nH]c3cccc(Br)c23)N1 | 10.1016/j.bmc.2013.09.011 | |||
| CHEMBL2058703 | 76321 | 0 | None | -9 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 318 | 1 | 3 | 2 | 2.0 | C/N=C1\NC(=O)/C(=C/c2c[nH]c3cccc(Br)c23)N1 | 10.1016/j.bmc.2013.09.011 | |||
| 9797313 | 101929 | 2 | None | -154 | 2 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 323 | 3 | 2 | 4 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2C | 10.1016/0960-894X(95)00115-A | |||
| CHEMBL301039 | 101929 | 2 | None | -154 | 2 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 323 | 3 | 2 | 4 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2C | 10.1016/0960-894X(95)00115-A | |||
| 135442121 | 112374 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 437 | 7 | 2 | 5 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(Br)c([N+](=O)[O-])c3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| CHEMBL329545 | 112374 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 437 | 7 | 2 | 5 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(Br)c([N+](=O)[O-])c3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| 135442121 | 112374 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 437 | 7 | 2 | 5 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(Br)c([N+](=O)[O-])c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL329545 | 112374 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 437 | 7 | 2 | 5 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(Br)c([N+](=O)[O-])c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 9797313 | 101929 | 2 | None | -154 | 2 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 323 | 3 | 2 | 4 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2C | 10.1021/jm960320m | |||
| CHEMBL301039 | 101929 | 2 | None | -154 | 2 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 323 | 3 | 2 | 4 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2C | 10.1021/jm960320m | |||
| 10757374 | 163092 | 0 | None | - | 1 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@H]1CN2CCC1CC2 | 10.1016/S0960-894X(01)80508-4 | |||
| CHEMBL41769 | 163092 | 0 | None | - | 1 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@H]1CN2CCC1CC2 | 10.1016/S0960-894X(01)80508-4 | |||
| 11520559 | 72313 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 750 | 16 | 2 | 12 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CCCCCC(=O)N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| CHEMBL198371 | 72313 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 750 | 16 | 2 | 12 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CCCCCC(=O)N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| 10757374 | 163092 | 0 | None | - | 1 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@H]1CN2CCC1CC2 | 10.1021/jm960320m | |||
| CHEMBL41769 | 163092 | 0 | None | - | 1 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@H]1CN2CCC1CC2 | 10.1021/jm960320m | |||
| 155544687 | 175031 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 312 | 7 | 1 | 2 | 4.6 | CCCCN1CCC(CCC(=O)c2ccc3[nH]ccc3c2)CC1 | 10.1016/j.ejmech.2018.10.064 | |||
| CHEMBL4567394 | 175031 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 312 | 7 | 1 | 2 | 4.6 | CCCCN1CCC(CCC(=O)c2ccc3[nH]ccc3c2)CC1 | 10.1016/j.ejmech.2018.10.064 | |||
| 235 | 2564 | 42 | None | -4 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm050234z | |||
| 5311299 | 2564 | 42 | None | -4 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm050234z | |||
| CHEMBL286136 | 2564 | 42 | None | -4 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm050234z | |||
| 44404965 | 72085 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 764 | 17 | 5 | 12 | 3.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCCCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3O)CC2)CC1 | 10.1021/jm050234z | |||
| CHEMBL197745 | 72085 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 764 | 17 | 5 | 12 | 3.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCCCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3O)CC2)CC1 | 10.1021/jm050234z | |||
| 44404960 | 72091 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 736 | 15 | 5 | 12 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3O)CC2)CC1 | 10.1021/jm050234z | |||
| CHEMBL197752 | 72091 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 736 | 15 | 5 | 12 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3O)CC2)CC1 | 10.1021/jm050234z | |||
| 11629247 | 72394 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 812 | 16 | 4 | 12 | 4.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCc2cccc(CNC(=O)C3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)c2)CC1 | 10.1021/jm050234z | |||
| CHEMBL198668 | 72394 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 812 | 16 | 4 | 12 | 4.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCc2cccc(CNC(=O)C3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)c2)CC1 | 10.1021/jm050234z | |||
| 235 | 2564 | 42 | None | -4 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm801327q | |||
| 5311299 | 2564 | 42 | None | -4 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm801327q | |||
| CHEMBL286136 | 2564 | 42 | None | -4 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm801327q | |||
| 42618248 | 187028 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 479 | 8 | 2 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)Cc2ccccc2Cl)CC1 | 10.1021/jm801327q | |||
| CHEMBL490852 | 187028 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 479 | 8 | 2 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)Cc2ccccc2Cl)CC1 | 10.1021/jm801327q | |||
| 71450247 | 82976 | 0 | None | 19 | 8 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 368 | 5 | 0 | 3 | 5.5 | CCCN1CCC(COc2nc3c(Cl)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | |||
| CHEMBL2181188 | 82976 | 0 | None | 19 | 8 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 368 | 5 | 0 | 3 | 5.5 | CCCN1CCC(COc2nc3c(Cl)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | |||
| 71712329 | 91389 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 454 | 7 | 2 | 5 | 2.3 | CC(=O)N1CCN(CCN2CCC(CNC(=O)c3cccc4[nH]c(C(C)C)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | |||
| CHEMBL2402899 | 91389 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 454 | 7 | 2 | 5 | 2.3 | CC(=O)N1CCN(CCN2CCC(CNC(=O)c3cccc4[nH]c(C(C)C)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | |||
| 44628133 | 84581 | 0 | None | 50 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 414 | 6 | 1 | 5 | 4.6 | Cn1cc2c(OCC3CCN(CCc4ccc(N)cc4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | |||
| CHEMBL2179675 | 84581 | 0 | None | 50 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 414 | 6 | 1 | 5 | 4.6 | Cn1cc2c(OCC3CCN(CCc4ccc(N)cc4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | |||
| CHEMBL2220953 | 84581 | 0 | None | 50 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 414 | 6 | 1 | 5 | 4.6 | Cn1cc2c(OCC3CCN(CCc4ccc(N)cc4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | |||
| 53320666 | 56457 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 447 | 6 | 2 | 5 | 3.8 | O=C(O)c1ccc(CN2CCC(CNC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2010.10.011 | |||
| CHEMBL1632176 | 56457 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 447 | 6 | 2 | 5 | 3.8 | O=C(O)c1ccc(CN2CCC(CNC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2010.10.011 | |||
| 44248319 | 195495 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 615 | 16 | 1 | 7 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN(C)CCCN(C)S(C)(=O)=O)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL553404 | 195495 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 615 | 16 | 1 | 7 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN(C)CCCN(C)S(C)(=O)=O)cc2ccccc21 | 10.1021/jm900881j | |||
| 44248680 | 195582 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 3.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCC(CNS(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL555223 | 195582 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 3.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCC(CNS(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | |||
| 44248313 91900492 | 195864 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 492 | 9 | 1 | 5 | 5.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL558719 | 195864 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 492 | 9 | 1 | 5 | 5.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | |||
| 71460941 | 82681 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 374 | 8 | 0 | 5 | 5.1 | CCCCN1CCC(COc2noc3cccc(OCC(C)(C)C)c23)CC1 | 10.1021/jm300953p | |||
| CHEMBL2179588 | 82681 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 374 | 8 | 0 | 5 | 5.1 | CCCCN1CCC(COc2noc3cccc(OCC(C)(C)C)c23)CC1 | 10.1021/jm300953p | |||
| 258 | 3567 | 31 | None | -1 | 7 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80508-4 | |||
| 5191 | 3567 | 31 | None | -1 | 7 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80508-4 | |||
| CHEMBL287045 | 3567 | 31 | None | -1 | 7 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80508-4 | |||
| 10447437 | 50066 | 0 | None | - | 1 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 298 | 5 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC1 | 10.1021/jm960320m | |||
| CHEMBL156970 | 50066 | 0 | None | - | 1 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 298 | 5 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC1 | 10.1021/jm960320m | |||
| 10498232 | 51366 | 0 | None | - | 1 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 352 | 5 | 1 | 5 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CC2CCC(CC2)C1 | 10.1021/jm960320m | |||
| CHEMBL158147 | 51366 | 0 | None | - | 1 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 352 | 5 | 1 | 5 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CC2CCC(CC2)C1 | 10.1021/jm960320m | |||
| 258 | 3567 | 31 | None | -1 | 7 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm960853v | |||
| 5191 | 3567 | 31 | None | -1 | 7 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm960853v | |||
| CHEMBL287045 | 3567 | 31 | None | -1 | 7 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm960853v | |||
| 258 | 3567 | 31 | None | -1 | 7 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm960320m | |||
| 5191 | 3567 | 31 | None | -1 | 7 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm960320m | |||
| CHEMBL287045 | 3567 | 31 | None | -1 | 7 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm960320m | |||
| 11166796 | 82676 | 0 | None | -2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | |||
| CHEMBL2179583 | 82676 | 0 | None | -2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | |||
| 235 | 2564 | 42 | None | -4 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | |||
| 5311299 | 2564 | 42 | None | -4 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | |||
| CHEMBL286136 | 2564 | 42 | None | -4 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | |||
| 235 | 2564 | 42 | None | -4 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm070552t | |||
| 5311299 | 2564 | 42 | None | -4 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm070552t | |||
| CHEMBL286136 | 2564 | 42 | None | -4 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm070552t | |||
| 155543353 | 173301 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 418 | 7 | 3 | 6 | 4.2 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(Cc2ccc(O)c(O)c2)CC1 | 10.1016/j.ejmech.2019.111596 | |||
| CHEMBL4526049 | 173301 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 418 | 7 | 3 | 6 | 4.2 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(Cc2ccc(O)c(O)c2)CC1 | 10.1016/j.ejmech.2019.111596 | |||
| 11643822 | 157859 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 1158 | 38 | 6 | 15 | 8.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCN(CCCCCCCCCCC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC(=O)NCC2CCNCC2)CC1 | 10.1021/jm050234z | |||
| CHEMBL408379 | 157859 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 1158 | 38 | 6 | 15 | 8.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCN(CCCCCCCCCCC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC(=O)NCC2CCNCC2)CC1 | 10.1021/jm050234z | |||
| 49783414 | 17677 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 320 | 7 | 1 | 5 | 2.9 | CCCCN1CCC(COC(=O)c2ccc(N)cc2OC)CC1 | 10.1021/jm100668r | |||
| CHEMBL1258451 | 17677 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 320 | 7 | 1 | 5 | 2.9 | CCCCN1CCC(COC(=O)c2ccc(N)cc2OC)CC1 | 10.1021/jm100668r | |||
| 70691118 | 77501 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 469 | 7 | 3 | 6 | 1.7 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN(C)C(N)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | |||
| CHEMBL2087327 | 77501 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 469 | 7 | 3 | 6 | 1.7 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN(C)C(N)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | |||
| 70686943 | 77505 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 497 | 7 | 2 | 6 | 2.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN(C)C(=O)N(C)C)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | |||
| CHEMBL2087331 | 77505 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 497 | 7 | 2 | 6 | 2.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN(C)C(=O)N(C)C)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | |||
| 70684789 | 77506 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 470 | 7 | 3 | 7 | 2.0 | COC(=O)NCC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | |||
| CHEMBL2087332 | 77506 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 470 | 7 | 3 | 7 | 2.0 | COC(=O)NCC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | |||
| 70695323 | 77510 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@H](O)CN(C)S(C)(=O)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | |||
| CHEMBL2087336 | 77510 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@H](O)CN(C)S(C)(=O)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | |||
| 44248923 | 194936 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL541968 | 194936 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | |||
| 44248080 91900498 | 195876 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 493 | 8 | 2 | 6 | 2.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCC[C@@H]2C(N)=O)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL558855 | 195876 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 493 | 8 | 2 | 6 | 2.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCC[C@@H]2C(N)=O)cc2ccccc21 | 10.1021/jm900881j | |||
| 44249057 91900485 | 196099 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 467 | 11 | 2 | 5 | 4.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCO)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL560876 | 196099 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 467 | 11 | 2 | 5 | 4.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCO)cc2ccccc21 | 10.1021/jm900881j | |||
| 5 | 139 | 72 | None | -288 | 54 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/np0601760 | |||
| 5202 | 139 | 72 | None | -288 | 54 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/np0601760 | |||
| CHEMBL39 | 139 | 72 | None | -288 | 54 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/np0601760 | |||
| DB08839 | 139 | 72 | None | -288 | 54 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/np0601760 | |||
| 118712567 | 114229 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 508 | 8 | 3 | 4 | 4.9 | O=C(NCC1CCN(Cc2ccc(NS(=O)(=O)C3CCCCC3)cc2)CC1)c1c[nH]c2ccccc12 | 10.1016/j.bmcl.2014.06.083 | |||
| CHEMBL3329801 | 114229 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 508 | 8 | 3 | 4 | 4.9 | O=C(NCC1CCN(Cc2ccc(NS(=O)(=O)C3CCCCC3)cc2)CC1)c1c[nH]c2ccccc12 | 10.1016/j.bmcl.2014.06.083 | |||
| 189 | 3492 | 39 | None | -2089 | 17 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 292 | 1 | 1 | 3 | 3.2 | O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1 | 10.1021/jm00014a004 | |||
| 5163 | 3492 | 39 | None | -2089 | 17 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 292 | 1 | 1 | 3 | 3.2 | O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1 | 10.1021/jm00014a004 | |||
| CHEMBL297784 | 3492 | 39 | None | -2089 | 17 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 292 | 1 | 1 | 3 | 3.2 | O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1 | 10.1021/jm00014a004 | |||
| 9913554 | 100992 | 0 | None | -6309 | 14 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 491 | 5 | 1 | 6 | 5.0 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1 | 10.1016/s0960-894x(02)00172-5 | |||
| CHEMBL29433 | 100992 | 0 | None | -6309 | 14 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 491 | 5 | 1 | 6 | 5.0 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1 | 10.1016/s0960-894x(02)00172-5 | |||
| 9928343 | 103470 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 349 | 4 | 2 | 4 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)NCC1C2CC3CC1CN(C3)C2 | 10.1016/j.bmcl.2004.09.005 | |||
| CHEMBL3085015 | 103470 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 349 | 4 | 2 | 4 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)NCC1C2CC3CC1CN(C3)C2 | 10.1016/j.bmcl.2004.09.005 | |||
| 155523661 | 170904 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 382 | 7 | 1 | 3 | 5.4 | COc1c(C(=O)CCC2CCN(CC3CCCCC3)CC2)ccc2[nH]ccc12 | 10.1016/j.ejmech.2018.10.064 | |||
| CHEMBL4454706 | 170904 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 382 | 7 | 1 | 3 | 5.4 | COc1c(C(=O)CCC2CCN(CC3CCCCC3)CC2)ccc2[nH]ccc12 | 10.1016/j.ejmech.2018.10.064 | |||
| 135453290 | 133606 | 33 | None | -169 | 8 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 191 | 2 | 2 | 4 | 1.1 | C[C@H](N)Cn1ncc2ccc(O)cc21 | 10.1021/jm050663x | |||
| CHEMBL371300 | 133606 | 33 | None | -169 | 8 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 191 | 2 | 2 | 4 | 1.1 | C[C@H](N)Cn1ncc2ccc(O)cc21 | 10.1021/jm050663x | |||
| 15544720 | 67168 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 292 | 2 | 2 | 3 | 2.0 | CN1CCC(NC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL18769 | 67168 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 292 | 2 | 2 | 3 | 2.0 | CN1CCC(NC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 136118640 | 76318 | 0 | None | -4 | 3 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 335 | 1 | 2 | 3 | 3.1 | CSC1=NC(=O)/C(=C/c2c[nH]c3cc(Br)ccc23)N1 | 10.1016/j.bmc.2013.09.011 | |||
| CHEMBL2058700 | 76318 | 0 | None | -4 | 3 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 335 | 1 | 2 | 3 | 3.1 | CSC1=NC(=O)/C(=C/c2c[nH]c3cc(Br)ccc23)N1 | 10.1016/j.bmc.2013.09.011 | |||
| 15544720 | 67168 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 292 | 2 | 2 | 3 | 2.0 | CN1CCC(NC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| CHEMBL18769 | 67168 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 292 | 2 | 2 | 3 | 2.0 | CN1CCC(NC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| 15544720 | 67168 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 292 | 2 | 2 | 3 | 2.0 | CN1CCC(NC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/0960-894X(96)00200-4 | |||
| CHEMBL18769 | 67168 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 292 | 2 | 2 | 3 | 2.0 | CN1CCC(NC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/0960-894X(96)00200-4 | |||
| 15544720 | 67168 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 292 | 2 | 2 | 3 | 2.0 | CN1CCC(NC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL18769 | 67168 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 292 | 2 | 2 | 3 | 2.0 | CN1CCC(NC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 10408029 | 16460 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 389 | 6 | 1 | 6 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2)CC1 | 10.1021/jm0009538 | |||
| CHEMBL123377 | 16460 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 389 | 6 | 1 | 6 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2)CC1 | 10.1021/jm0009538 | |||
| 44288600 | 101117 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 335 | 3 | 2 | 4 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CC1CN(C3)C2 | 10.1016/j.bmcl.2004.09.005 | |||
| CHEMBL295155 | 101117 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 335 | 3 | 2 | 4 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CC1CN(C3)C2 | 10.1016/j.bmcl.2004.09.005 | |||
| 56850385 | 71477 | 0 | None | -72 | 3 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 351 | 7 | 1 | 3 | 3.1 | O=C1C2CCCN2C(=O)N1CCCCNCc1ccc2ccccc2c1 | 10.1021/jm2007886 | |||
| CHEMBL1926730 | 71477 | 0 | None | -72 | 3 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 351 | 7 | 1 | 3 | 3.1 | O=C1C2CCCN2C(=O)N1CCCCNCc1ccc2ccccc2c1 | 10.1021/jm2007886 | |||
| CHEMBL1962454 | 71477 | 0 | None | -72 | 3 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 351 | 7 | 1 | 3 | 3.1 | O=C1C2CCCN2C(=O)N1CCCCNCc1ccc2ccccc2c1 | 10.1021/jm2007886 | |||
| 11174673 | 173631 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 321 | 3 | 3 | 5 | 1.6 | Cc1cn2c(N)c(Cl)cc(C(=O)NCC3CCNCC3)c2n1 | 10.1016/j.ejmech.2019.111569 | |||
| CHEMBL4533922 | 173631 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 321 | 3 | 3 | 5 | 1.6 | Cc1cn2c(N)c(Cl)cc(C(=O)NCC3CCNCC3)c2n1 | 10.1016/j.ejmech.2019.111569 | |||
| 11135810 | 206504 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 606 | 11 | 1 | 8 | 5.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCCCN2C(=O)c3cccc4c(N(C)C)ccc(c34)C2=O)CC1 | 10.1021/jm0307887 | |||
| CHEMBL88355 | 206504 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 606 | 11 | 1 | 8 | 5.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCCCN2C(=O)c3cccc4c(N(C)C)ccc(c34)C2=O)CC1 | 10.1021/jm0307887 | |||
| 56850387 | 71478 | 0 | None | -13 | 3 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 365 | 8 | 1 | 3 | 3.2 | O=C1C2CCCN2C(=O)N1CCCCNCCc1ccc2ccccc2c1 | 10.1021/jm2007886 | |||
| CHEMBL1926731 | 71478 | 0 | None | -13 | 3 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 365 | 8 | 1 | 3 | 3.2 | O=C1C2CCCN2C(=O)N1CCCCNCCc1ccc2ccccc2c1 | 10.1021/jm2007886 | |||
| CHEMBL1962455 | 71478 | 0 | None | -13 | 3 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 365 | 8 | 1 | 3 | 3.2 | O=C1C2CCCN2C(=O)N1CCCCNCCc1ccc2ccccc2c1 | 10.1021/jm2007886 | |||
| 44404955 | 133520 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 868 | 24 | 4 | 15 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCCOCCOCCOCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| CHEMBL370796 | 133520 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 868 | 24 | 4 | 15 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCCOCCOCCOCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| 10764565 | 49013 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 2.7 | COc1cc(N)c(Cl)cc1C(=O)OCC[N+]12CCC(CC1)CC2 | 10.1021/jm960320m | |||
| CHEMBL156088 | 49013 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 2.7 | COc1cc(N)c(Cl)cc1C(=O)OCC[N+]12CCC(CC1)CC2 | 10.1021/jm960320m | |||
| 10548275 | 48511 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 307 | 5 | 1 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)OCC[n+]1ccccc1 | 10.1021/jm960320m | |||
| CHEMBL155631 | 48511 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 307 | 5 | 1 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)OCC[n+]1ccccc1 | 10.1021/jm960320m | |||
| 44371350 | 120168 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 342 | 5 | 1 | 6 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CC(C)OC(C)C1 | 10.1021/jm960320m | |||
| CHEMBL351570 | 120168 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 342 | 5 | 1 | 6 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CC(C)OC(C)C1 | 10.1021/jm960320m | |||
| 71451950 | 82675 | 8 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | |||
| CHEMBL2179582 | 82675 | 8 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | |||
| 49783208 | 17608 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 362 | 6 | 1 | 6 | 3.0 | CCCCN1CCC(COC(=O)c2cc(C)c(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | |||
| CHEMBL1258222 | 17608 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 362 | 6 | 1 | 6 | 3.0 | CCCCN1CCC(COC(=O)c2cc(C)c(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | |||
| 258 | 3567 | 31 | None | 1 | 7 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/j.bmc.2008.11.045 | |||
| 5191 | 3567 | 31 | None | 1 | 7 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/j.bmc.2008.11.045 | |||
| CHEMBL287045 | 3567 | 31 | None | 1 | 7 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/j.bmc.2008.11.045 | |||
| 71712611 | 91377 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 478 | 8 | 3 | 7 | -0.1 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(CNC(=O)c3cccc4[nH]cnc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | |||
| CHEMBL2402887 | 91377 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 478 | 8 | 3 | 7 | -0.1 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(CNC(=O)c3cccc4[nH]cnc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | |||
| 44248439 | 196192 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 464 | 7 | 1 | 5 | 4.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL561398 | 196192 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 464 | 7 | 1 | 5 | 4.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | |||
| 10584 | 1463 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1016/j.ejmech.2019.02.076 | |||
| 86582973 | 1463 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1016/j.ejmech.2019.02.076 | |||
| CHEMBL3417009 | 1463 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1016/j.ejmech.2019.02.076 | |||
| 71451950 | 82675 | 8 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | |||
| CHEMBL2179582 | 82675 | 8 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | |||
| 11603514 | 71490 | 0 | None | -5 | 4 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 390 | 11 | 1 | 5 | 4.0 | O=C1CSC(=O)N1CCCCCCCCNCC1CCc2ccccc2O1 | 10.1021/jm2007886 | |||
| CHEMBL1926760 | 71490 | 0 | None | -5 | 4 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 390 | 11 | 1 | 5 | 4.0 | O=C1CSC(=O)N1CCCCCCCCNCC1CCc2ccccc2O1 | 10.1021/jm2007886 | |||
| CHEMBL1962492 | 71490 | 0 | None | -5 | 4 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 390 | 11 | 1 | 5 | 4.0 | O=C1CSC(=O)N1CCCCCCCCNCC1CCc2ccccc2O1 | 10.1021/jm2007886 | |||
| 209710 | 101847 | 1 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 282 | 4 | 1 | 3 | 3.4 | O=C(Nc1cccc(Cl)c1)OCCN1CCCCC1 | 10.1021/jm960853v | |||
| CHEMBL300476 | 101847 | 1 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 282 | 4 | 1 | 3 | 3.4 | O=C(Nc1cccc(Cl)c1)OCCN1CCCCC1 | 10.1021/jm960853v | |||
| 44240743 | 6757 | 15 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 370 | 7 | 2 | 3 | 4.3 | O=C(NCCCCN1CCCCC1)Nc1ccc(-c2ccc(F)cc2)nc1 | 10.1021/jm901692q | |||
| CHEMBL1083787 | 6757 | 15 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 370 | 7 | 2 | 3 | 4.3 | O=C(NCCCCN1CCCCC1)Nc1ccc(-c2ccc(F)cc2)nc1 | 10.1021/jm901692q | |||
| 136118651 | 76324 | 0 | None | -1 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 318 | 1 | 3 | 2 | 2.0 | C/N=C1\NC(=O)/C(=C/c2c[nH]c3c(Br)cccc23)N1 | 10.1016/j.bmc.2013.09.011 | |||
| CHEMBL2058706 | 76324 | 0 | None | -1 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 318 | 1 | 3 | 2 | 2.0 | C/N=C1\NC(=O)/C(=C/c2c[nH]c3c(Br)cccc23)N1 | 10.1016/j.bmc.2013.09.011 | |||
| 260 | 3869 | 54 | None | -19 | 5 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/0960-894X(96)00200-4 | |||
| 2775 | 3869 | 54 | None | -19 | 5 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/0960-894X(96)00200-4 | |||
| 656665 | 3869 | 54 | None | -19 | 5 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/0960-894X(96)00200-4 | |||
| CHEMBL56564 | 3869 | 54 | None | -19 | 5 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/0960-894X(96)00200-4 | |||
| DB11699 | 3869 | 54 | None | -19 | 5 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/0960-894X(96)00200-4 | |||
| 76313431 | 103370 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 330 | 2 | 2 | 5 | 1.5 | COc1ccc2[nH]c(=O)n(C(=O)N[C@H]3C[C@@H]4CC[C@H](C3)N4C)c2c1 | 10.1016/j.bmc.2008.11.045 | |||
| CHEMBL3084582 | 103370 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 330 | 2 | 2 | 5 | 1.5 | COc1ccc2[nH]c(=O)n(C(=O)N[C@H]3C[C@@H]4CC[C@H](C3)N4C)c2c1 | 10.1016/j.bmc.2008.11.045 | |||
| 9839803 | 92872 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 313 | 3 | 2 | 4 | 2.2 | O=C(NCC1CCNCC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmc.2013.09.004 | |||
| CHEMBL2440452 | 92872 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 313 | 3 | 2 | 4 | 2.2 | O=C(NCC1CCNCC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmc.2013.09.004 | |||
| 10757502 91929739 | 195125 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 312 | 3 | 2 | 4 | 2.6 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | |||
| CHEMBL550064 | 195125 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 312 | 3 | 2 | 4 | 2.6 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | |||
| 10757502 91929739 | 195125 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 312 | 3 | 2 | 4 | 2.6 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)c2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL550064 | 195125 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 312 | 3 | 2 | 4 | 2.6 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)c2ccccc21 | 10.1021/jm900881j | |||
| 44248312 91900490 | 195130 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 531 | 12 | 2 | 6 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCS(=O)(=O)O)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL550122 | 195130 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 531 | 12 | 2 | 6 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCS(=O)(=O)O)cc2ccccc21 | 10.1021/jm900881j | |||
| 44248187 91900482 | 195380 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 409 | 7 | 1 | 4 | 4.5 | CCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1021/jm900881j | |||
| CHEMBL551941 | 195380 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 409 | 7 | 1 | 4 | 4.5 | CCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1021/jm900881j | |||
| 44247811 | 195471 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 369 | 8 | 3 | 5 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCO)CC1 | 10.1021/jm900881j | |||
| CHEMBL552693 | 195471 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 369 | 8 | 3 | 5 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCO)CC1 | 10.1021/jm900881j | |||
| 44249056 91900483 | 196337 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 451 | 10 | 1 | 4 | 5.7 | CCCCCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1021/jm900881j | |||
| CHEMBL562400 | 196337 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 451 | 10 | 1 | 4 | 5.7 | CCCCCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1021/jm900881j | |||
| 10574402 91900484 | 196472 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 425 | 8 | 2 | 5 | 3.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCO)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL563261 | 196472 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 425 | 8 | 2 | 5 | 3.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCO)cc2ccccc21 | 10.1021/jm900881j | |||
| 44248433 91900494 | 196741 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 529 | 7 | 1 | 7 | 1.9 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL565146 | 196741 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 529 | 7 | 1 | 7 | 1.9 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | |||
| 44247947 | 195333 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 433 | 9 | 3 | 6 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCS(=O)(=O)O)CC1 | 10.1021/jm900881j | |||
| CHEMBL551678 | 195333 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 433 | 9 | 3 | 6 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCS(=O)(=O)O)CC1 | 10.1021/jm900881j | |||
| 10347130 | 206034 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 536 | 7 | 2 | 8 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CN2C(=O)c3cccc4c(N)ccc(c34)C2=O)CC1 | 10.1021/jm0307887 | |||
| CHEMBL85125 | 206034 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 536 | 7 | 2 | 8 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CN2C(=O)c3cccc4c(N)ccc(c34)C2=O)CC1 | 10.1021/jm0307887 | |||
| 10812045 | 15521 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 419 | 7 | 1 | 7 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2OC)CC1 | 10.1021/jm0009538 | |||
| CHEMBL121766 | 15521 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 419 | 7 | 1 | 7 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2OC)CC1 | 10.1021/jm0009538 | |||
| 14403199 | 116610 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 324 | 3 | 1 | 5 | 2.7 | COc1cc(N)c(Cl)cc1C(=O)OC1CC2CCC(C1)N2C | 10.1016/S0960-894X(01)80508-4 | |||
| CHEMBL33676 | 116610 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 324 | 3 | 1 | 5 | 2.7 | COc1cc(N)c(Cl)cc1C(=O)OC1CC2CCC(C1)N2C | 10.1016/S0960-894X(01)80508-4 | |||
| 14403199 | 116610 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 324 | 3 | 1 | 5 | 2.7 | COc1cc(N)c(Cl)cc1C(=O)OC1CC2CCC(C1)N2C | 10.1021/jm960320m | |||
| CHEMBL33676 | 116610 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 324 | 3 | 1 | 5 | 2.7 | COc1cc(N)c(Cl)cc1C(=O)OC1CC2CCC(C1)N2C | 10.1021/jm960320m | |||
| 21588627 | 106622 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 438 | 7 | 1 | 4 | 4.8 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3c2ncn3Cc2ccccc2)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL314299 | 106622 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 438 | 7 | 1 | 4 | 4.8 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3c2ncn3Cc2ccccc2)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 21588627 | 106622 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 438 | 7 | 1 | 4 | 4.8 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3c2ncn3Cc2ccccc2)CC1 | 10.1021/jm020807x | |||
| CHEMBL314299 | 106622 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 438 | 7 | 1 | 4 | 4.8 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3c2ncn3Cc2ccccc2)CC1 | 10.1021/jm020807x | |||
| 21588627 | 106622 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 438 | 7 | 1 | 4 | 4.8 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3c2ncn3Cc2ccccc2)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL314299 | 106622 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 438 | 7 | 1 | 4 | 4.8 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3c2ncn3Cc2ccccc2)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 44404958 | 72407 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 764 | 17 | 5 | 12 | 3.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCCCCC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3O)CC2)CC1 | 10.1021/jm050234z | |||
| CHEMBL198719 | 72407 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 764 | 17 | 5 | 12 | 3.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCCCCC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3O)CC2)CC1 | 10.1021/jm050234z | |||
| 11813852 | 112017 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 574 | 10 | 2 | 8 | 4.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | |||
| CHEMBL328918 | 112017 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 574 | 10 | 2 | 8 | 4.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | |||
| 9800656 | 15550 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | |||
| CHEMBL121913 | 15550 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | |||
| 49783211 | 17640 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 488 | 7 | 1 | 6 | 3.8 | CCCCN1CCC(COC(=O)c2cc(I)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | |||
| CHEMBL1258339 | 17640 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 488 | 7 | 1 | 6 | 3.8 | CCCCN1CCC(COC(=O)c2cc(I)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | |||
| 11005668 | 206642 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 504 | 9 | 2 | 11 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNc2ccc([N+](=O)[O-])c3nonc23)CC1 | 10.1021/jm0307887 | |||
| CHEMBL89225 | 206642 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 504 | 9 | 2 | 11 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNc2ccc([N+](=O)[O-])c3nonc23)CC1 | 10.1021/jm0307887 | |||
| 71462777 | 82965 | 0 | None | 83 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 335 | 5 | 0 | 4 | 4.3 | CCCN1CCC(COc2nc3ccccc3c3ncccc23)CC1 | 10.1021/jm300943r | |||
| CHEMBL2181171 | 82965 | 0 | None | 83 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 335 | 5 | 0 | 4 | 4.3 | CCCN1CCC(COc2nc3ccccc3c3ncccc23)CC1 | 10.1021/jm300943r | |||
| 10788092 | 53588 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 416 | 7 | 1 | 6 | 3.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)c2ccccc2)CC1 | 10.1021/jm960320m | |||
| CHEMBL160237 | 53588 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 416 | 7 | 1 | 6 | 3.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)c2ccccc2)CC1 | 10.1021/jm960320m | |||
| 10449091 | 119965 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 326 | 5 | 1 | 5 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCCC1C | 10.1021/jm960320m | |||
| CHEMBL349809 | 119965 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 326 | 5 | 1 | 5 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCCC1C | 10.1021/jm960320m | |||
| 49780155 | 17140 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 393 | 7 | 1 | 8 | 2.6 | CCCCN1CCC(COC(=O)c2cc([N+](=O)[O-])c(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | |||
| CHEMBL1255606 | 17140 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 393 | 7 | 1 | 8 | 2.6 | CCCCN1CCC(COC(=O)c2cc([N+](=O)[O-])c(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | |||
| 44629280 | 82725 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 351 | 6 | 0 | 4 | 4.6 | CCCCN1CCC(COc2nc3ccccc3c3cn(C)cc23)CC1 | 10.1021/jm300573d | |||
| CHEMBL2179679 | 82725 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 351 | 6 | 0 | 4 | 4.6 | CCCCN1CCC(COc2nc3ccccc3c3cn(C)cc23)CC1 | 10.1021/jm300573d | |||
| 11627949 | 76421 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 532 | 8 | 2 | 8 | 1.3 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@H](O)CN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | |||
| CHEMBL2059587 | 76421 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 532 | 8 | 2 | 8 | 1.3 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@H](O)CN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | |||
| 44248193 | 194809 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 593 | 12 | 1 | 7 | 5.0 | CCOC(=O)N1CCN(CCCCCCCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2cc4ccccc4n(C(C)C)c2=O)C3)CC1 | 10.1021/jm900881j | |||
| CHEMBL538956 | 194809 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 593 | 12 | 1 | 7 | 5.0 | CCOC(=O)N1CCN(CCCCCCCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2cc4ccccc4n(C(C)C)c2=O)C3)CC1 | 10.1021/jm900881j | |||
| 21252890 | 195476 | 1 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 300 | 4 | 2 | 4 | 2.3 | CC(C)n1nc(C(=O)NCC2CCNCC2)c2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL552796 | 195476 | 1 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 300 | 4 | 2 | 4 | 2.3 | CC(C)n1nc(C(=O)NCC2CCNCC2)c2ccccc21 | 10.1021/jm900881j | |||
| 44248321 | 195581 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 541 | 8 | 1 | 6 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCN(c3ccccc3)CC2)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL555222 | 195581 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 541 | 8 | 1 | 6 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCN(c3ccccc3)CC2)cc2ccccc21 | 10.1021/jm900881j | |||
| 235 | 2564 | 42 | None | -4 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | |||
| 5311299 | 2564 | 42 | None | -4 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | |||
| CHEMBL286136 | 2564 | 42 | None | -4 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | |||
| 10717193 | 16782 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/jm0009538 | |||
| CHEMBL124485 | 16782 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/jm0009538 | |||
| 15544714 | 66283 | 7 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 258 | 2 | 2 | 3 | 1.4 | CN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| CHEMBL18473 | 66283 | 7 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 258 | 2 | 2 | 3 | 1.4 | CN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1021/jm020807x | |||
| 15544714 | 66283 | 7 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 258 | 2 | 2 | 3 | 1.4 | CN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/0960-894X(96)00200-4 | |||
| CHEMBL18473 | 66283 | 7 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 258 | 2 | 2 | 3 | 1.4 | CN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/0960-894X(96)00200-4 | |||
| 15544714 | 66283 | 7 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 258 | 2 | 2 | 3 | 1.4 | CN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL18473 | 66283 | 7 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 258 | 2 | 2 | 3 | 1.4 | CN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 1471834 | 3629 | 42 | None | -4 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 366 | 2 | 0 | 2 | 5.5 | O=C1C(=Nc2cccc(c2)C(F)(F)F)c2c(N1c1ccccc1)cccc2 | 10.1021/jm060001n | |||
| 6126 | 3629 | 42 | None | -4 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 366 | 2 | 0 | 2 | 5.5 | O=C1C(=Nc2cccc(c2)C(F)(F)F)c2c(N1c1ccccc1)cccc2 | 10.1021/jm060001n | |||
| CHEMBL210288 | 3629 | 42 | None | -4 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 366 | 2 | 0 | 2 | 5.5 | O=C1C(=Nc2cccc(c2)C(F)(F)F)c2c(N1c1ccccc1)cccc2 | 10.1021/jm060001n | |||
| 15544714 | 66283 | 7 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 258 | 2 | 2 | 3 | 1.4 | CN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| CHEMBL18473 | 66283 | 7 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 258 | 2 | 2 | 3 | 1.4 | CN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | |||
| 30049 | 188203 | 1 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 282 | 4 | 1 | 3 | 3.4 | O=C(Nc1ccc(Cl)cc1)OCCN1CCCCC1 | 10.1021/jm960853v | |||
| CHEMBL49907 | 188203 | 1 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 282 | 4 | 1 | 3 | 3.4 | O=C(Nc1ccc(Cl)cc1)OCCN1CCCCC1 | 10.1021/jm960853v | |||
| 108182 | 4131 | 22 | None | -1 | 16 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 10.1016/S0960-894X(01)80508-4 | |||
| 245 | 4131 | 22 | None | -1 | 16 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 10.1016/S0960-894X(01)80508-4 | |||
| CHEMBL18041 | 4131 | 22 | None | -1 | 16 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 10.1016/S0960-894X(01)80508-4 | |||
| 11966400 | 206844 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 588 | 11 | 2 | 8 | 4.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | |||
| CHEMBL90559 | 206844 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 588 | 11 | 2 | 8 | 4.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | |||
| 10779499 | 38074 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 285 | 2 | 3 | 4 | 1.0 | Nc1ccc(C(=O)NC2CN3CCC2CC3)c2[nH]cnc12 | 10.1021/jm991076c | |||
| CHEMBL146068 | 38074 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 285 | 2 | 3 | 4 | 1.0 | Nc1ccc(C(=O)NC2CN3CCC2CC3)c2[nH]cnc12 | 10.1021/jm991076c | |||
| 44247808 | 195379 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 395 | 10 | 2 | 4 | 4.5 | CCCCCCCCN1CCC(NC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm900881j | |||
| CHEMBL551940 | 195379 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 395 | 10 | 2 | 4 | 4.5 | CCCCCCCCN1CCC(NC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm900881j | |||
| 44247813 | 195592 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 411 | 11 | 3 | 5 | 3.5 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCO)CC1 | 10.1021/jm900881j | |||
| CHEMBL555447 | 195592 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 411 | 11 | 3 | 5 | 3.5 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCO)CC1 | 10.1021/jm900881j | |||
| 10837280 91900491 | 195822 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 450 | 6 | 1 | 5 | 3.8 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL558259 | 195822 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 450 | 6 | 1 | 5 | 3.8 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | |||
| 73354085 | 92871 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 385 | 6 | 2 | 5 | 3.4 | CCCCN1CCC(CNC(=O)c2c3n(c4cc(O)ccc24)CCCO3)CC1 | 10.1016/j.bmc.2013.09.004 | |||
| CHEMBL2440451 | 92871 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 385 | 6 | 2 | 5 | 3.4 | CCCCN1CCC(CNC(=O)c2c3n(c4cc(O)ccc24)CCCO3)CC1 | 10.1016/j.bmc.2013.09.004 | |||
| 44249186 | 195316 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 327 | 4 | 2 | 4 | 2.3 | CC(C)n1c(=O)c(C(=O)NCC2CCNCC2)cc2ccccc21 | 10.1021/jm900881j | |||
| CHEMBL551535 | 195316 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 327 | 4 | 2 | 4 | 2.3 | CC(C)n1c(=O)c(C(=O)NCC2CCNCC2)cc2ccccc21 | 10.1021/jm900881j | |||
| 44247815 | 196475 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 456 | 6 | 2 | 6 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN2C(=O)c3ccccc3C2=O)CC1 | 10.1021/jm900881j | |||
| CHEMBL563276 | 196475 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 456 | 6 | 2 | 6 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN2C(=O)c3ccccc3C2=O)CC1 | 10.1021/jm900881j | |||
| 24865727 | 193113 | 0 | None | -5011 | 11 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 479 | 7 | 0 | 5 | 4.4 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCS5(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
| CHEMBL522708 | 193113 | 0 | None | -5011 | 11 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 479 | 7 | 0 | 5 | 4.4 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCS5(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
| 11686414 | 71749 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 764 | 17 | 4 | 12 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCC(=O)NCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| CHEMBL196633 | 71749 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 764 | 17 | 4 | 12 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCC(=O)NCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| 44404966 | 133449 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 834 | 22 | 5 | 12 | 5.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCCCCCCCCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3O)CC2)CC1 | 10.1021/jm050234z | |||
| CHEMBL370646 | 133449 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 834 | 22 | 5 | 12 | 5.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCCCCCCCCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3O)CC2)CC1 | 10.1021/jm050234z | |||
| 9800656 | 15550 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | |||
| CHEMBL121913 | 15550 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | |||
| 44323264 | 207112 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 322 | 2 | 1 | 5 | 2.1 | Nc1c(Cl)cc(C(=O)O[C@@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | |||
| CHEMBL92100 | 207112 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 322 | 2 | 1 | 5 | 2.1 | Nc1c(Cl)cc(C(=O)O[C@@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | |||
| 235 | 2564 | 42 | None | -4 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | |||
| 5311299 | 2564 | 42 | None | -4 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | |||
| CHEMBL286136 | 2564 | 42 | None | -4 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | |||
| 151758 | 189336 | 4 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 278 | 5 | 1 | 4 | 2.7 | COc1ccccc1NC(=O)OCCN1CCCCC1 | 10.1021/jm960853v | |||
| CHEMBL51251 | 189336 | 4 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 278 | 5 | 1 | 4 | 2.7 | COc1ccccc1NC(=O)OCCN1CCCCC1 | 10.1021/jm960853v | |||
| 10541689 | 102053 | 4 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 292 | 6 | 1 | 4 | 3.1 | COc1ccccc1NC(=O)OCCCN1CCCCC1 | 10.1021/jm960853v | |||
| CHEMBL301967 | 102053 | 4 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 292 | 6 | 1 | 4 | 3.1 | COc1ccccc1NC(=O)OCCCN1CCCCC1 | 10.1021/jm960853v | |||
| 44573 | 56993 | 1 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 297 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(C)CC1 | 10.1016/0960-894X(95)00115-A | |||
| CHEMBL164425 | 56993 | 1 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 297 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(C)CC1 | 10.1016/0960-894X(95)00115-A | |||
| 49783416 | 17713 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 319 | 7 | 2 | 4 | 2.5 | CCCCN1CCC(CNC(=O)c2ccc(N)c(OC)c2)CC1 | 10.1021/jm100668r | |||
| CHEMBL1258559 | 17713 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 319 | 7 | 2 | 4 | 2.5 | CCCCN1CCC(CNC(=O)c2ccc(N)c(OC)c2)CC1 | 10.1021/jm100668r | |||
| 44404961 | 133014 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 764 | 17 | 5 | 12 | 4.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3O)CC2)CC1 | 10.1021/jm050234z | |||
| CHEMBL370227 | 133014 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 764 | 17 | 5 | 12 | 4.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3O)CC2)CC1 | 10.1021/jm050234z | |||
| 11693471 | 135239 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 778 | 18 | 4 | 12 | 4.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCC(=O)NCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| CHEMBL372479 | 135239 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 778 | 18 | 4 | 12 | 4.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCC(=O)NCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | |||
| 10757373 | 49587 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 310 | 5 | 1 | 5 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CC=CCC1 | 10.1021/jm960320m | |||
| CHEMBL156579 | 49587 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 310 | 5 | 1 | 5 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CC=CCC1 | 10.1021/jm960320m | |||
| 49783207 | 17578 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 362 | 7 | 1 | 6 | 3.2 | CCCCN1CCC(COC(=O)c2ccc(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | |||
| CHEMBL1258109 | 17578 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 362 | 7 | 1 | 6 | 3.2 | CCCCN1CCC(COC(=O)c2ccc(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | |||
| 11794824 | 17936 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cncnc2)CC1 | 10.1021/jm0009538 | |||
| CHEMBL125926 | 17936 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cncnc2)CC1 | 10.1021/jm0009538 | |||
| 44371317 | 50063 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 338 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(Cl)cc1C(=O)OCCN1C2CCCC1CC2 | 10.1021/jm960320m | |||
| CHEMBL156965 | 50063 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 338 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(Cl)cc1C(=O)OCCN1C2CCCC1CC2 | 10.1021/jm960320m | |||
| 183782 | 3398 | 20 | None | 69 | 13 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.ejmech.2018.10.064 | |||
| 237 | 3398 | 20 | None | 69 | 13 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.ejmech.2018.10.064 | |||
| CHEMBL85251 | 3398 | 20 | None | 69 | 13 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.ejmech.2018.10.064 | |||
| 10584 | 1463 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1016/j.ejmech.2018.10.064 | |||
| 86582973 | 1463 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1016/j.ejmech.2018.10.064 | |||
| CHEMBL3417009 | 1463 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1016/j.ejmech.2018.10.064 | |||
| 9927789 | 111502 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 337 | 5 | 2 | 4 | 2.5 | Nc1c(Cl)cc(C(=O)NCCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | |||
| CHEMBL327798 | 111502 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 337 | 5 | 2 | 4 | 2.5 | Nc1c(Cl)cc(C(=O)NCCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | |||
| 10526438 | 17295 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 425 | 6 | 1 | 8 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cnc(Cl)nc2)CC1 | 10.1021/jm0009538 | |||
| CHEMBL125716 | 17295 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 425 | 6 | 1 | 8 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cnc(Cl)nc2)CC1 | 10.1021/jm0009538 | |||
| 1782 | 2518 | 84 | None | -11 | 22 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(96)00002-9 | |||
| 241 | 2518 | 84 | None | -11 | 22 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(96)00002-9 | |||
| 4168 | 2518 | 84 | None | -11 | 22 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(96)00002-9 | |||
| CHEMBL86 | 2518 | 84 | None | -11 | 22 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(96)00002-9 | |||
| DB01233 | 2518 | 84 | None | -11 | 22 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(96)00002-9 | |||
| 10828800 | 100189 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@@H]1CN2CCC1CC2 | 10.1016/S0960-894X(01)80508-4 | |||
| CHEMBL288199 | 100189 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@@H]1CN2CCC1CC2 | 10.1016/S0960-894X(01)80508-4 | |||
| 10828800 | 100189 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@@H]1CN2CCC1CC2 | 10.1021/jm960320m | |||
| CHEMBL288199 | 100189 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@@H]1CN2CCC1CC2 | 10.1021/jm960320m | |||
| 75201901 | 166425 | 19 | None | -676 | 24 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 356 | 3 | 0 | 6 | 4.9 | Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12 | 10.1021/acs.jmedchem.9b00351 | |||
| CHEMBL4277264 | 166425 | 19 | None | -676 | 24 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 356 | 3 | 0 | 6 | 4.9 | Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12 | 10.1021/acs.jmedchem.9b00351 | |||
| 136118647 | 76320 | 0 | None | -3 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 240 | 1 | 3 | 2 | 1.2 | C/N=C1\NC(=O)/C(=C/c2c[nH]c3ccccc23)N1 | 10.1016/j.bmc.2013.09.011 | |||
| CHEMBL2058702 | 76320 | 0 | None | -3 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 240 | 1 | 3 | 2 | 1.2 | C/N=C1\NC(=O)/C(=C/c2c[nH]c3ccccc23)N1 | 10.1016/j.bmc.2013.09.011 | |||
| 44323245 | 107024 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 322 | 2 | 1 | 5 | 2.1 | Nc1c(Cl)cc(C(=O)O[C@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | |||
| CHEMBL315443 | 107024 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 322 | 2 | 1 | 5 | 2.1 | Nc1c(Cl)cc(C(=O)O[C@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | |||
| 10930618 | 107039 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 729 | 19 | 2 | 9 | 5.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CCCCCCCCCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | |||
| CHEMBL315526 | 107039 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 729 | 19 | 2 | 9 | 5.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CCCCCCCCCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | |||
| 6918107 | 78146 | 16 | None | -1 | 5 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 319 | 2 | 0 | 4 | 3.5 | Cc1nccn1C[C@H]1CCc2c(c3cccc4c3n2CCC4)C1=O | 10.1021/jm00075a026 | |||
| CHEMBL2103778 | 78146 | 16 | None | -1 | 5 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 319 | 2 | 0 | 4 | 3.5 | Cc1nccn1C[C@H]1CCc2c(c3cccc4c3n2CCC4)C1=O | 10.1021/jm00075a026 | |||
| 1782 | 2518 | 84 | None | -11 | 22 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(95)00115-A | |||
| 241 | 2518 | 84 | None | -11 | 22 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(95)00115-A | |||
| 4168 | 2518 | 84 | None | -11 | 22 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(95)00115-A | |||
| CHEMBL86 | 2518 | 84 | None | -11 | 22 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(95)00115-A | |||
| DB01233 | 2518 | 84 | None | -11 | 22 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(95)00115-A | |||
| 1782 | 2518 | 84 | None | -11 | 22 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80508-4 | |||
| 241 | 2518 | 84 | None | -11 | 22 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80508-4 | |||
| 4168 | 2518 | 84 | None | -11 | 22 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80508-4 | |||
| CHEMBL86 | 2518 | 84 | None | -11 | 22 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80508-4 | |||
| DB01233 | 2518 | 84 | None | -11 | 22 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80508-4 | |||
| 5 | 139 | 72 | None | -117 | 54 | Rat | 7.7 | pKd | = | 7.7 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8813606 | |||
| 5202 | 139 | 72 | None | -117 | 54 | Rat | 7.7 | pKd | = | 7.7 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8813606 | |||
| CHEMBL39 | 139 | 72 | None | -117 | 54 | Rat | 7.7 | pKd | = | 7.7 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8813606 | |||
| DB08839 | 139 | 72 | None | -117 | 54 | Rat | 7.7 | pKd | = | 7.7 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8813606 | |||
| 5 | 139 | 72 | None | -288 | 54 | Human | 8.6 | pKd | = | 8.6 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10646498 | |||
| 5202 | 139 | 72 | None | -288 | 54 | Human | 8.6 | pKd | = | 8.6 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10646498 | |||
| CHEMBL39 | 139 | 72 | None | -288 | 54 | Human | 8.6 | pKd | = | 8.6 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10646498 | |||
| DB08839 | 139 | 72 | None | -288 | 54 | Human | 8.6 | pKd | = | 8.6 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10646498 | |||
| 236 | 3397 | 0 | None | - | 1 | Rat | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | 474 | 8 | 1 | 7 | 4.2 | COc1cc(N)c(cc1C(=O)OCC1CCN(CC1)CCCc1ccc2c(c1)OCCO2)Cl | 9225293 | |||
| 239 | 3397 | 0 | None | - | 1 | Rat | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | 474 | 8 | 1 | 7 | 4.2 | COc1cc(N)c(cc1C(=O)OCC1CCN(CC1)CCCc1ccc2c(c1)OCCO2)Cl | 9225293 | |||
| 5311417 | 3397 | 0 | None | - | 1 | Rat | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | 474 | 8 | 1 | 7 | 4.2 | COc1cc(N)c(cc1C(=O)OCC1CCN(CC1)CCCc1ccc2c(c1)OCCO2)Cl | 9225293 | |||
| CHEMBL1908857 | 3397 | 0 | None | - | 1 | Rat | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | 474 | 8 | 1 | 7 | 4.2 | COc1cc(N)c(cc1C(=O)OCC1CCN(CC1)CCCc1ccc2c(c1)OCCO2)Cl | 9225293 | |||
| 119376 | 1841 | 48 | 3H-GR-113808 | -1 | 26 | Human | 10.7 | pKi | = | 10.7 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| 119376 | 1841 | 48 | 3H-GR-113808 | -2 | 26 | Rat | 10.7 | pKi | = | 10.7 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| 247 | 1841 | 48 | 3H-GR-113808 | -1 | 26 | Human | 10.7 | pKi | = | 10.7 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| 247 | 1841 | 48 | 3H-GR-113808 | -2 | 26 | Rat | 10.7 | pKi | = | 10.7 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| CHEMBL33884 | 1841 | 48 | 3H-GR-113808 | -1 | 26 | Human | 10.7 | pKi | = | 10.7 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| CHEMBL33884 | 1841 | 48 | 3H-GR-113808 | -2 | 26 | Rat | 10.7 | pKi | = | 10.7 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| 119376 | 1841 | 48 | 3H-GR-113808 | -2 | 26 | Rat | 10.5 | pKi | = | 10.5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| 247 | 1841 | 48 | 3H-GR-113808 | -2 | 26 | Rat | 10.5 | pKi | = | 10.5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| CHEMBL33884 | 1841 | 48 | 3H-GR-113808 | -2 | 26 | Rat | 10.5 | pKi | = | 10.5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| 119376 | 1841 | 48 | 3H-GR-113808 | -1 | 26 | Human | 10.1 | pKi | = | 10.1 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| 247 | 1841 | 48 | 3H-GR-113808 | -1 | 26 | Human | 10.1 | pKi | = | 10.1 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| CHEMBL33884 | 1841 | 48 | 3H-GR-113808 | -1 | 26 | Human | 10.1 | pKi | = | 10.1 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| 121881 | 3490 | 27 | 3H-GR-113808 | 11 | 14 | Human | 10.0 | pKi | = | 10 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | |||
| 256 | 3490 | 27 | 3H-GR-113808 | 11 | 14 | Human | 10.0 | pKi | = | 10 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | |||
| CHEMBL68131 | 3490 | 27 | 3H-GR-113808 | 11 | 14 | Human | 10.0 | pKi | = | 10 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | |||
| 119376 | 1841 | 48 | 3H-GR-113808 | -1 | 26 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| 247 | 1841 | 48 | 3H-GR-113808 | -1 | 26 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| CHEMBL33884 | 1841 | 48 | 3H-GR-113808 | -1 | 26 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| 119376 | 1841 | 48 | 3H-GR-113808 | 1 | 26 | Mouse | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| 247 | 1841 | 48 | 3H-GR-113808 | 1 | 26 | Mouse | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| CHEMBL33884 | 1841 | 48 | 3H-GR-113808 | 1 | 26 | Mouse | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| 119376 | 1841 | 48 | 3H-GR-113808 | -1 | 26 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| 247 | 1841 | 48 | 3H-GR-113808 | -1 | 26 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| CHEMBL33884 | 1841 | 48 | 3H-GR-113808 | -1 | 26 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| 119376 | 1841 | 48 | 3H-GR-113808 | 1 | 26 | Mouse | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| 247 | 1841 | 48 | 3H-GR-113808 | 1 | 26 | Mouse | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| CHEMBL33884 | 1841 | 48 | 3H-GR-113808 | 1 | 26 | Mouse | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| 121881 | 3490 | 27 | 3H-RS 57639 | -11 | 14 | Rat | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | |||
| 256 | 3490 | 27 | 3H-RS 57639 | -11 | 14 | Rat | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | |||
| CHEMBL68131 | 3490 | 27 | 3H-RS 57639 | -11 | 14 | Rat | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | |||
| 121881 | 3490 | 27 | 3H-GR-113808 | -11 | 14 | Rat | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | |||
| 256 | 3490 | 27 | 3H-GR-113808 | -11 | 14 | Rat | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | |||
| CHEMBL68131 | 3490 | 27 | 3H-GR-113808 | -11 | 14 | Rat | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | |||
| 121881 | 3490 | 27 | 3H-5HT | -11 | 14 | Rat | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | |||
| 256 | 3490 | 27 | 3H-5HT | -11 | 14 | Rat | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | |||
| CHEMBL68131 | 3490 | 27 | 3H-5HT | -11 | 14 | Rat | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | |||
| 119376 | 1841 | 48 | 3H-GR-113808 | -2 | 26 | Rat | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| 247 | 1841 | 48 | 3H-GR-113808 | -2 | 26 | Rat | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| CHEMBL33884 | 1841 | 48 | 3H-GR-113808 | -2 | 26 | Rat | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| 240 | 944 | 43 | 3H-5HT | -8 | 24 | Rat | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 2769 | 944 | 43 | 3H-5HT | -8 | 24 | Rat | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 44279790 | 944 | 43 | 3H-5HT | -8 | 24 | Rat | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 660 | 944 | 43 | 3H-5HT | -8 | 24 | Rat | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| CHEMBL1729 | 944 | 43 | 3H-5HT | -8 | 24 | Rat | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| CHEMBL560739 | 944 | 43 | 3H-5HT | -8 | 24 | Rat | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| DB00604 | 944 | 43 | 3H-5HT | -8 | 24 | Rat | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| None | 216011 | 0 | 3H-GR-113808 | 1 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 367 | 2 | 1 | 6 | 2.4 | CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl | None | |||
| 108182 | 4131 | 22 | 3H-5HT | -1 | 16 | Rat | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 245 | 4131 | 22 | 3H-5HT | -1 | 16 | Rat | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| CHEMBL18041 | 4131 | 22 | 3H-5HT | -1 | 16 | Rat | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 57174031 | 215940 | 0 | 3H-5HT | -33 | 19 | Rat | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | |||
| 1809 | 134 | 32 | 3H-5HT | -46773 | 36 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 1809 | 134 | 32 | 3H-GR-113808 | -46773 | 36 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-5HT | -46773 | 36 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-GR-113808 | -46773 | 36 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-5HT | -46773 | 36 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-GR-113808 | -46773 | 36 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 107 | 141 | 121 | 3H-GR-113808 | -389 | 30 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1833 | 141 | 121 | 3H-GR-113808 | -389 | 30 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| CHEMBL8165 | 141 | 121 | 3H-GR-113808 | -389 | 30 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1220 | 187 | 55 | 3H-GR-113808 | -2511 | 44 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 31 | 187 | 55 | 3H-GR-113808 | -2511 | 44 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 7 | 187 | 55 | 3H-GR-113808 | -2511 | 44 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| CHEMBL56 | 187 | 55 | 3H-GR-113808 | -2511 | 44 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 1524 | 2181 | 96 | 3H-GR-113808 | -758 | 52 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 197 | 2181 | 96 | 3H-GR-113808 | -758 | 52 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 3822 | 2181 | 96 | 3H-GR-113808 | -758 | 52 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 88 | 2181 | 96 | 3H-GR-113808 | -758 | 52 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| CHEMBL51 | 2181 | 96 | 3H-GR-113808 | -758 | 52 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| DB12465 | 2181 | 96 | 3H-GR-113808 | -758 | 52 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 1621 | 2429 | 17 | 3H-GR-113808 | -3235 | 45 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 17 | 2429 | 17 | 3H-GR-113808 | -3235 | 45 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 5761 | 2429 | 17 | 3H-GR-113808 | -3235 | 45 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| CHEMBL263881 | 2429 | 17 | 3H-GR-113808 | -3235 | 45 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| DB04829 | 2429 | 17 | 3H-GR-113808 | -3235 | 45 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 2543 | 3707 | 68 | 3H-GR-113808 | -281 | 32 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | 3H-GR-113808 | -281 | 32 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | 3H-GR-113808 | -281 | 32 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | 3H-GR-113808 | -281 | 32 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | 3H-GR-113808 | -281 | 32 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 108182 | 4131 | 22 | 3H-RS 57639 | -1 | 16 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 245 | 4131 | 22 | 3H-RS 57639 | -1 | 16 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| CHEMBL18041 | 4131 | 22 | 3H-RS 57639 | -1 | 16 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| None | 216379 | 0 | UNDEFINED | -1122 | 11 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 243 | 3 | 1 | 4 | 2.7 | CCC1=CC2=C(O1)C=CC3=C2N(N=C3)CC(C)N | None | |||
| None | 217080 | 0 | UNDEFINED | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 394 | 5 | 1 | 4 | 5.1 | CC1=CC(=C(C=C1)OC)NC(=O)OC2CC3CCCC(C2)N3CC4=CC=CC=C4 | None | |||
| 1809 | 134 | 32 | 3H-GR-113808 | -109647 | 36 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 1809 | 134 | 32 | 3H-GR-113808 | -109647 | 36 | Mouse | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 1809 | 134 | 32 | 3H-GR-113808 | -46773 | 36 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-GR-113808 | -109647 | 36 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-GR-113808 | -109647 | 36 | Mouse | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-GR-113808 | -46773 | 36 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-GR-113808 | -109647 | 36 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-GR-113808 | -109647 | 36 | Mouse | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-GR-113808 | -46773 | 36 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 1220 | 187 | 55 | 3H-GR-113808 | -2511 | 44 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 31 | 187 | 55 | 3H-GR-113808 | -2511 | 44 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 7 | 187 | 55 | 3H-GR-113808 | -2511 | 44 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| CHEMBL56 | 187 | 55 | 3H-GR-113808 | -2511 | 44 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 2477 | 745 | 59 | 3H-GR-113808 | -1548 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| 36 | 745 | 59 | 3H-GR-113808 | -1548 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| 437 | 745 | 59 | 3H-GR-113808 | -1548 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| CHEMBL49 | 745 | 59 | 3H-GR-113808 | -1548 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| DB00490 | 745 | 59 | 3H-GR-113808 | -1548 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | |||
| 1150 | 3878 | 121 | 3H-5HT | -436 | 25 | Mouse | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | |||
| 125 | 3878 | 121 | 3H-5HT | -436 | 25 | Mouse | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | |||
| CHEMBL6640 | 3878 | 121 | 3H-5HT | -436 | 25 | Mouse | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | |||
| DB08653 | 3878 | 121 | 3H-5HT | -436 | 25 | Mouse | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | |||
| 44208932 | 140707 | 7 | UNDEFINED | -89125 | 36 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 475 | 5 | 1 | 3 | 6.8 | Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 | None | |||
| CHEMBL381689 | 140707 | 7 | UNDEFINED | -89125 | 36 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 475 | 5 | 1 | 3 | 6.8 | Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 | None | |||
| None | 216322 | 0 | 3H-GR-113808 | -331 | 6 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 390 | 4 | 1 | 4 | 3.2 | C1CN(CCN1CCN2C3=CC=CC=C3NC2=O)C4=CC=C(C=C4)C(F)(F)F | None | |||
| None | 216450 | 0 | Functional | -660 | 28 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 322 | 5 | 2 | 3 | 4.1 | CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl | None | |||
| None | 216450 | 0 | UNDEFINED | -660 | 28 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 322 | 5 | 2 | 3 | 4.1 | CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl | None | |||
| 108182 | 4131 | 22 | 3H-GR-113808 | 1 | 16 | Mouse | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 245 | 4131 | 22 | 3H-GR-113808 | 1 | 16 | Mouse | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| CHEMBL18041 | 4131 | 22 | 3H-GR-113808 | 1 | 16 | Mouse | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 107 | 141 | 121 | 3H-5HT | -257 | 30 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1833 | 141 | 121 | 3H-5HT | -257 | 30 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| CHEMBL8165 | 141 | 121 | 3H-5HT | -257 | 30 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 3035240 | 215978 | 0 | 3H-GR-113808 | 1 | 4 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 359 | 3 | 2 | 4 | 2.6 | COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl | None | |||
| 4595 | 176715 | 106 | 3H-GR113808 | -3 | 15 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 293 | 2 | 0 | 4 | 3.1 | Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O | None | |||
| CHEMBL46 | 176715 | 106 | 3H-GR113808 | -3 | 15 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 293 | 2 | 0 | 4 | 3.1 | Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O | None | |||
| 240 | 944 | 43 | 3H-GR-113808 | -8 | 24 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 2769 | 944 | 43 | 3H-GR-113808 | -8 | 24 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 44279790 | 944 | 43 | 3H-GR-113808 | -8 | 24 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 660 | 944 | 43 | 3H-GR-113808 | -8 | 24 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| CHEMBL1729 | 944 | 43 | 3H-GR-113808 | -8 | 24 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| CHEMBL560739 | 944 | 43 | 3H-GR-113808 | -8 | 24 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| DB00604 | 944 | 43 | 3H-GR-113808 | -8 | 24 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 107 | 141 | 121 | 3H-GR-113808 | -257 | 30 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1833 | 141 | 121 | 3H-GR-113808 | -257 | 30 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| CHEMBL8165 | 141 | 121 | 3H-GR-113808 | -257 | 30 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 5 | 139 | 72 | 3H-GR-113808 | -288 | 54 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5 | 139 | 72 | 3H-GR-113808 | -117 | 54 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-GR-113808 | -288 | 54 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-GR-113808 | -117 | 54 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-GR-113808 | -288 | 54 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-GR-113808 | -117 | 54 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-GR-113808 | -288 | 54 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-GR-113808 | -117 | 54 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 240 | 944 | 43 | 3H-GR-113808 | -8 | 24 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 2769 | 944 | 43 | 3H-GR-113808 | -8 | 24 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 44279790 | 944 | 43 | 3H-GR-113808 | -8 | 24 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 660 | 944 | 43 | 3H-GR-113808 | -8 | 24 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| CHEMBL1729 | 944 | 43 | 3H-GR-113808 | -8 | 24 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| CHEMBL560739 | 944 | 43 | 3H-GR-113808 | -8 | 24 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| DB00604 | 944 | 43 | 3H-GR-113808 | -8 | 24 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 108182 | 4131 | 22 | 3H-5HT | -1 | 16 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 245 | 4131 | 22 | 3H-5HT | -1 | 16 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| CHEMBL18041 | 4131 | 22 | 3H-5HT | -1 | 16 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 108182 | 4131 | 22 | 3H-GR-113808 | -1 | 16 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 108182 | 4131 | 22 | 3H-RS 57639 | -1 | 16 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 245 | 4131 | 22 | 3H-GR-113808 | -1 | 16 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 245 | 4131 | 22 | 3H-RS 57639 | -1 | 16 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| CHEMBL18041 | 4131 | 22 | 3H-GR-113808 | -1 | 16 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| CHEMBL18041 | 4131 | 22 | 3H-RS 57639 | -1 | 16 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 130946 | 202758 | 2 | UNDEFINED | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 328 | 2 | 1 | 5 | 2.0 | CCn1c(=O)n(C(=O)NC2CC3CCC(C2)N3C)c2ccccc21 | None | |||
| CHEMBL62023 | 202758 | 2 | UNDEFINED | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 328 | 2 | 1 | 5 | 2.0 | CCn1c(=O)n(C(=O)NC2CC3CCC(C2)N3C)c2ccccc21 | None | |||
| 3035240 | 215978 | 0 | 3H-GR-113808 | -1 | 4 | Mouse | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 359 | 3 | 2 | 4 | 2.6 | COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl | None | |||
| 108182 | 4131 | 22 | 3H-5HT | -1 | 16 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 245 | 4131 | 22 | 3H-5HT | -1 | 16 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| CHEMBL18041 | 4131 | 22 | 3H-5HT | -1 | 16 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 5 | 139 | 72 | 3H-GR-113808 | -117 | 54 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-GR-113808 | -117 | 54 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-GR-113808 | -117 | 54 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-GR-113808 | -117 | 54 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 152 | 364 | 29 | 3H-GR-113808 | -89 | 18 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | |||
| 2107 | 364 | 29 | 3H-GR-113808 | -89 | 18 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | |||
| CHEMBL275854 | 364 | 29 | 3H-GR-113808 | -89 | 18 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | |||
| 107 | 141 | 121 | 3H-GR-113808 | -389 | 30 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1833 | 141 | 121 | 3H-GR-113808 | -389 | 30 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| CHEMBL8165 | 141 | 121 | 3H-GR-113808 | -389 | 30 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 5 | 139 | 72 | 3H-GR-113808 | -117 | 54 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-GR-113808 | -117 | 54 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-GR-113808 | -117 | 54 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-GR-113808 | -117 | 54 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 240 | 944 | 43 | 3H-GR-113808 | -11 | 24 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 240 | 944 | 43 | 3H-RS 57639 | -8 | 24 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 2769 | 944 | 43 | 3H-GR-113808 | -11 | 24 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 2769 | 944 | 43 | 3H-RS 57639 | -8 | 24 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 44279790 | 944 | 43 | 3H-GR-113808 | -11 | 24 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 44279790 | 944 | 43 | 3H-RS 57639 | -8 | 24 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 660 | 944 | 43 | 3H-GR-113808 | -11 | 24 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 660 | 944 | 43 | 3H-RS 57639 | -8 | 24 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| CHEMBL1729 | 944 | 43 | 3H-GR-113808 | -11 | 24 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| CHEMBL1729 | 944 | 43 | 3H-RS 57639 | -8 | 24 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| CHEMBL560739 | 944 | 43 | 3H-GR-113808 | -11 | 24 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| CHEMBL560739 | 944 | 43 | 3H-RS 57639 | -8 | 24 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| DB00604 | 944 | 43 | 3H-GR-113808 | -11 | 24 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| DB00604 | 944 | 43 | 3H-RS 57639 | -8 | 24 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 57174031 | 215940 | 0 | 3H-GR-113808 | -8 | 19 | Mouse | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | |||
| None | 216011 | 0 | 3H-RS 57639 | -2 | 5 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 367 | 2 | 1 | 6 | 2.4 | CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl | None | |||
| 57174031 | 215940 | 0 | 3H-5HT | -33 | 19 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | |||
| 3035240 | 215978 | 0 | 3H-GR-113808 | -2 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 359 | 3 | 2 | 4 | 2.6 | COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl | None | |||
| None | 216011 | 0 | 3H-GR-113808 | 1 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 367 | 2 | 1 | 6 | 2.4 | CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl | None | |||
| 108182 | 4131 | 22 | 3H-GR-113808 | -1 | 16 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 245 | 4131 | 22 | 3H-GR-113808 | -1 | 16 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| CHEMBL18041 | 4131 | 22 | 3H-GR-113808 | -1 | 16 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 258 | 3567 | 31 | 3H-5HT | -1 | 7 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| 258 | 3567 | 31 | 3H-GR-113808 | -1 | 7 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| 5191 | 3567 | 31 | 3H-5HT | -1 | 7 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| 5191 | 3567 | 31 | 3H-GR-113808 | -1 | 7 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| CHEMBL287045 | 3567 | 31 | 3H-5HT | -1 | 7 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| CHEMBL287045 | 3567 | 31 | 3H-GR-113808 | -1 | 7 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| 108182 | 4131 | 22 | 3H-GR-113808 | 1 | 16 | Mouse | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 245 | 4131 | 22 | 3H-GR-113808 | 1 | 16 | Mouse | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| CHEMBL18041 | 4131 | 22 | 3H-GR-113808 | 1 | 16 | Mouse | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 5 | 139 | 72 | 3H-RS 57639 | -117 | 54 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-RS 57639 | -117 | 54 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-RS 57639 | -117 | 54 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-RS 57639 | -117 | 54 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 57174031 | 215940 | 0 | 3H-GR-113808 | -6 | 19 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | |||
| 5 | 139 | 72 | 3H-5HT | -117 | 54 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-5HT | -117 | 54 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-5HT | -117 | 54 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-5HT | -117 | 54 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 130 | 3500 | 47 | 35S-GTPGammaS | -562 | 13 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 3378093 | 3500 | 47 | 35S-GTPGammaS | -562 | 13 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| CHEMBL281350 | 3500 | 47 | 35S-GTPGammaS | -562 | 13 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| None | 216011 | 0 | 3H-GR-113808 | -2 | 5 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 367 | 2 | 1 | 6 | 2.4 | CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl | None | |||
| None | 216011 | 0 | 3H-ZACOPRIDE | -2 | 5 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 367 | 2 | 1 | 6 | 2.4 | CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl | None | |||
| 108182 | 4131 | 22 | 3H-GR-113808 | 1 | 16 | Mouse | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 245 | 4131 | 22 | 3H-GR-113808 | 1 | 16 | Mouse | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| CHEMBL18041 | 4131 | 22 | 3H-GR-113808 | 1 | 16 | Mouse | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| None | 215973 | 0 | 3H-GR-113808 | 4 | 2 | Mouse | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 336 | 1 | 2 | 4 | 1.9 | CN1C2CCC1CC(C2)NC(=O)N3C4=CC=CC=C4NC3=O.Cl | None | |||
| 107 | 141 | 121 | 3H-GR-113808 | -457 | 30 | Mouse | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1833 | 141 | 121 | 3H-GR-113808 | -457 | 30 | Mouse | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| CHEMBL8165 | 141 | 121 | 3H-GR-113808 | -457 | 30 | Mouse | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 3035240 | 215978 | 0 | 3H-GR-113808 | 1 | 4 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 359 | 3 | 2 | 4 | 2.6 | COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl | None | |||
| 240 | 944 | 43 | 3H-5HT | -8 | 24 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 2769 | 944 | 43 | 3H-5HT | -8 | 24 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 44279790 | 944 | 43 | 3H-5HT | -8 | 24 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 660 | 944 | 43 | 3H-5HT | -8 | 24 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| CHEMBL1729 | 944 | 43 | 3H-5HT | -8 | 24 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| CHEMBL560739 | 944 | 43 | 3H-5HT | -8 | 24 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| DB00604 | 944 | 43 | 3H-5HT | -8 | 24 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 258 | 3567 | 31 | 3H-RS 57639 | -1 | 7 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| 5191 | 3567 | 31 | 3H-RS 57639 | -1 | 7 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| CHEMBL287045 | 3567 | 31 | 3H-RS 57639 | -1 | 7 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| 3035240 | 215978 | 0 | 3H-5HT | 1 | 4 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 359 | 3 | 2 | 4 | 2.6 | COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl | None | |||
| 57174031 | 215940 | 0 | 3H-GR-113808 | -33 | 19 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | |||
| 3035240 | 215978 | 0 | 3H-GR-113808 | -2 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 359 | 3 | 2 | 4 | 2.6 | COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl | None | |||
| 3035240 | 215978 | 0 | 3H-GR-113808 | 1 | 4 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 359 | 3 | 2 | 4 | 2.6 | COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl | None | |||
| 3035240 | 215978 | 0 | 3H-RS 57639 | 1 | 4 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 359 | 3 | 2 | 4 | 2.6 | COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl | None | |||
| None | 216011 | 0 | 3H-GR-113808 | -1 | 5 | Mouse | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 367 | 2 | 1 | 6 | 2.4 | CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl | None | |||
| 152 | 364 | 29 | 3H-5HT | -89 | 18 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | |||
| 2107 | 364 | 29 | 3H-5HT | -89 | 18 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | |||
| CHEMBL275854 | 364 | 29 | 3H-5HT | -89 | 18 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | |||
| 3035240 | 215978 | 0 | 3H-5HT | 1 | 4 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 359 | 3 | 2 | 4 | 2.6 | COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl | None | |||
| 108182 | 4131 | 22 | 3H-GR-113808 | -2 | 16 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 245 | 4131 | 22 | 3H-GR-113808 | -2 | 16 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| CHEMBL18041 | 4131 | 22 | 3H-GR-113808 | -2 | 16 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 240 | 944 | 43 | 3H-GR113808 | -11 | 24 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 2769 | 944 | 43 | 3H-GR113808 | -11 | 24 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 44279790 | 944 | 43 | 3H-GR113808 | -11 | 24 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 660 | 944 | 43 | 3H-GR113808 | -11 | 24 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| CHEMBL1729 | 944 | 43 | 3H-GR113808 | -11 | 24 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| CHEMBL560739 | 944 | 43 | 3H-GR113808 | -11 | 24 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| DB00604 | 944 | 43 | 3H-GR113808 | -11 | 24 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 119376 | 1841 | 48 | 3H-5HT | -2 | 26 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| 247 | 1841 | 48 | 3H-5HT | -2 | 26 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| CHEMBL33884 | 1841 | 48 | 3H-5HT | -2 | 26 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| 119376 | 1841 | 48 | 3H-RS 57639 | -2 | 26 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| 247 | 1841 | 48 | 3H-RS 57639 | -2 | 26 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| CHEMBL33884 | 1841 | 48 | 3H-RS 57639 | -2 | 26 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | |||
| 108182 | 4131 | 22 | 3H-GR-113808 | 1 | 16 | Mouse | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 245 | 4131 | 22 | 3H-GR-113808 | 1 | 16 | Mouse | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| CHEMBL18041 | 4131 | 22 | 3H-GR-113808 | 1 | 16 | Mouse | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 107 | 141 | 121 | 3H-5HT | -257 | 30 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1833 | 141 | 121 | 3H-5HT | -257 | 30 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| CHEMBL8165 | 141 | 121 | 3H-5HT | -257 | 30 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 108182 | 4131 | 22 | 3H-5HT | -1 | 16 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 245 | 4131 | 22 | 3H-5HT | -1 | 16 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| CHEMBL18041 | 4131 | 22 | 3H-5HT | -1 | 16 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 5 | 139 | 72 | 3H-GR-113808 | -288 | 54 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-GR-113808 | -288 | 54 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-GR-113808 | -288 | 54 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-GR-113808 | -288 | 54 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 107 | 141 | 121 | 3H-RS 57639 | -257 | 30 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1833 | 141 | 121 | 3H-RS 57639 | -257 | 30 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| CHEMBL8165 | 141 | 121 | 3H-RS 57639 | -257 | 30 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 108182 | 4131 | 22 | 3H-5HT | -1 | 16 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 245 | 4131 | 22 | 3H-5HT | -1 | 16 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| CHEMBL18041 | 4131 | 22 | 3H-5HT | -1 | 16 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 1809 | 134 | 32 | 3H-5HT | -46773 | 36 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 1809 | 134 | 32 | 3H-GR-113808 | -46773 | 36 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-5HT | -46773 | 36 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-GR-113808 | -46773 | 36 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-5HT | -46773 | 36 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-GR-113808 | -46773 | 36 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 240 | 944 | 43 | 3H-GR-113808 | -5 | 24 | Mouse | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 2769 | 944 | 43 | 3H-GR-113808 | -5 | 24 | Mouse | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 44279790 | 944 | 43 | 3H-GR-113808 | -5 | 24 | Mouse | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 660 | 944 | 43 | 3H-GR-113808 | -5 | 24 | Mouse | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| CHEMBL1729 | 944 | 43 | 3H-GR-113808 | -5 | 24 | Mouse | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| CHEMBL560739 | 944 | 43 | 3H-GR-113808 | -5 | 24 | Mouse | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| DB00604 | 944 | 43 | 3H-GR-113808 | -5 | 24 | Mouse | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 5 | 139 | 72 | 3H-GR-113808 | -117 | 54 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-GR-113808 | -117 | 54 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-GR-113808 | -117 | 54 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-GR-113808 | -117 | 54 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 107 | 141 | 121 | 3H-5HT | -257 | 30 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1833 | 141 | 121 | 3H-5HT | -257 | 30 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| CHEMBL8165 | 141 | 121 | 3H-5HT | -257 | 30 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 107 | 141 | 121 | 3H-GR-113808 | -257 | 30 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1833 | 141 | 121 | 3H-GR-113808 | -257 | 30 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| CHEMBL8165 | 141 | 121 | 3H-GR-113808 | -257 | 30 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1782 | 2518 | 84 | 3H-GR-113808 | -25 | 22 | Mouse | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| 241 | 2518 | 84 | 3H-GR-113808 | -25 | 22 | Mouse | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| 4168 | 2518 | 84 | 3H-GR-113808 | -25 | 22 | Mouse | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| CHEMBL86 | 2518 | 84 | 3H-GR-113808 | -25 | 22 | Mouse | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| DB01233 | 2518 | 84 | 3H-GR-113808 | -25 | 22 | Mouse | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| 107 | 141 | 121 | 3H-GR-113808 | -257 | 30 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1833 | 141 | 121 | 3H-GR-113808 | -257 | 30 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| CHEMBL8165 | 141 | 121 | 3H-GR-113808 | -257 | 30 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 235 | 2564 | 42 | 3H-GR-113808 | -4 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | None | |||
| 5311299 | 2564 | 42 | 3H-GR-113808 | -4 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | None | |||
| CHEMBL286136 | 2564 | 42 | 3H-GR-113808 | -4 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | None | |||
| None | 216011 | 0 | 3H-GR-113808 | -2 | 5 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 367 | 2 | 1 | 6 | 2.4 | CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl | None | |||
| 4595 | 176715 | 106 | None | -3 | 15 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 293 | 2 | 0 | 4 | 3.1 | Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O | None | |||
| CHEMBL46 | 176715 | 106 | None | -3 | 15 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 293 | 2 | 0 | 4 | 3.1 | Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O | None | |||
| 107 | 141 | 121 | 3H-GR-113808 | -389 | 30 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 107 | 141 | 121 | 3H-GR-113808 | -257 | 30 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1833 | 141 | 121 | 3H-GR-113808 | -389 | 30 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1833 | 141 | 121 | 3H-GR-113808 | -257 | 30 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| CHEMBL8165 | 141 | 121 | 3H-GR-113808 | -389 | 30 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| CHEMBL8165 | 141 | 121 | 3H-GR-113808 | -257 | 30 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 57174031 | 215940 | 0 | 3H-GR-113808 | -33 | 19 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | |||
| 57174031 | 215940 | 0 | 3H-RS 57639 | -33 | 19 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | |||
| 1809 | 134 | 32 | 3H-RS 57639 | -46773 | 36 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-RS 57639 | -46773 | 36 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-RS 57639 | -46773 | 36 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 240 | 944 | 43 | 3H-GR-113808 | -5 | 24 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 2769 | 944 | 43 | 3H-GR-113808 | -5 | 24 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 44279790 | 944 | 43 | 3H-GR-113808 | -5 | 24 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 660 | 944 | 43 | 3H-GR-113808 | -5 | 24 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| CHEMBL1729 | 944 | 43 | 3H-GR-113808 | -5 | 24 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| CHEMBL560739 | 944 | 43 | 3H-GR-113808 | -5 | 24 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| DB00604 | 944 | 43 | 3H-GR-113808 | -5 | 24 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 107 | 141 | 121 | 3H-GR-113808 | -457 | 30 | Mouse | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1833 | 141 | 121 | 3H-GR-113808 | -457 | 30 | Mouse | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| CHEMBL8165 | 141 | 121 | 3H-GR-113808 | -457 | 30 | Mouse | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 2780 | 110529 | 36 | 3H-GR-113808 | -41 | 10 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 373 | 5 | 2 | 4 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1 | None | |||
| CHEMBL325109 | 110529 | 36 | 3H-GR-113808 | -41 | 10 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 373 | 5 | 2 | 4 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1 | None | |||
| None | 216011 | 0 | 3H-GR-113808 | -1 | 5 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 367 | 2 | 1 | 6 | 2.4 | CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl | None | |||
| 57174031 | 215940 | 0 | 3H-GR-113808 | -33 | 19 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | |||
| 5 | 139 | 72 | 3H-GR-113808 | -288 | 54 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5 | 139 | 72 | 3H-GR-113808 | -154 | 54 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-GR-113808 | -288 | 54 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-GR-113808 | -154 | 54 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-GR-113808 | -288 | 54 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-GR-113808 | -154 | 54 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-GR-113808 | -288 | 54 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-GR-113808 | -154 | 54 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 1782 | 2518 | 84 | None | -25 | 22 | Mouse | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| 241 | 2518 | 84 | None | -25 | 22 | Mouse | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| 4168 | 2518 | 84 | None | -25 | 22 | Mouse | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| CHEMBL86 | 2518 | 84 | None | -25 | 22 | Mouse | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| DB01233 | 2518 | 84 | None | -25 | 22 | Mouse | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| 1782 | 2518 | 84 | None | -11 | 22 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| 241 | 2518 | 84 | None | -11 | 22 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| 4168 | 2518 | 84 | None | -11 | 22 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| CHEMBL86 | 2518 | 84 | None | -11 | 22 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| DB01233 | 2518 | 84 | None | -11 | 22 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| 5 | 139 | 72 | 3H-5HT | -117 | 54 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-5HT | -117 | 54 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-5HT | -117 | 54 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-5HT | -117 | 54 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 258 | 3567 | 31 | 3H-GR-113808 | 1 | 7 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| 258 | 3567 | 31 | 3H-GR-113808 | -1 | 7 | Mouse | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| 5191 | 3567 | 31 | 3H-GR-113808 | 1 | 7 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| 5191 | 3567 | 31 | 3H-GR-113808 | -1 | 7 | Mouse | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| CHEMBL287045 | 3567 | 31 | 3H-GR-113808 | 1 | 7 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| CHEMBL287045 | 3567 | 31 | 3H-GR-113808 | -1 | 7 | Mouse | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| 57174031 | 215940 | 0 | None | -6 | 19 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | |||
| 119584 | 2595 | 102 | None | -1 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | None | |||
| 1848 | 2595 | 102 | None | -1 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | None | |||
| 242 | 2595 | 102 | None | -1 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | None | |||
| CHEMBL60889 | 2595 | 102 | None | -1 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | None | |||
| DB11675 | 2595 | 102 | None | -1 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | None | |||
| 2780 | 110529 | 36 | None | -20 | 10 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 373 | 5 | 2 | 4 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1 | None | |||
| CHEMBL325109 | 110529 | 36 | None | -20 | 10 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 373 | 5 | 2 | 4 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1 | None | |||
| 240 | 944 | 43 | 3H-GR-113808 | -11 | 24 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 2769 | 944 | 43 | 3H-GR-113808 | -11 | 24 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 44279790 | 944 | 43 | 3H-GR-113808 | -11 | 24 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 660 | 944 | 43 | 3H-GR-113808 | -11 | 24 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| CHEMBL1729 | 944 | 43 | 3H-GR-113808 | -11 | 24 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| CHEMBL560739 | 944 | 43 | 3H-GR-113808 | -11 | 24 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| DB00604 | 944 | 43 | 3H-GR-113808 | -11 | 24 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| None | 216011 | 0 | 3H-GR-113808 | 1 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 367 | 2 | 1 | 6 | 2.4 | CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl | None | |||
| None | 216011 | 0 | 3H-GR-113808 | -2 | 5 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 367 | 2 | 1 | 6 | 2.4 | CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl | None | |||
| 57174031 | 215940 | 0 | None | -8 | 19 | Mouse | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | |||
| 57174031 | 215940 | 0 | None | -33 | 19 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | |||
| 240 | 944 | 43 | None | -5 | 24 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 2769 | 944 | 43 | None | -5 | 24 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 44279790 | 944 | 43 | None | -5 | 24 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 660 | 944 | 43 | None | -5 | 24 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| CHEMBL1729 | 944 | 43 | None | -5 | 24 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| CHEMBL560739 | 944 | 43 | None | -5 | 24 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| DB00604 | 944 | 43 | None | -5 | 24 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 240 | 944 | 43 | None | -11 | 24 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 2769 | 944 | 43 | None | -11 | 24 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 44279790 | 944 | 43 | None | -11 | 24 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 660 | 944 | 43 | None | -11 | 24 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| CHEMBL1729 | 944 | 43 | None | -11 | 24 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| CHEMBL560739 | 944 | 43 | None | -11 | 24 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| DB00604 | 944 | 43 | None | -11 | 24 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 258 | 3567 | 31 | 3H-GR-113808 | -1 | 7 | Mouse | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| 5191 | 3567 | 31 | 3H-GR-113808 | -1 | 7 | Mouse | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| CHEMBL287045 | 3567 | 31 | 3H-GR-113808 | -1 | 7 | Mouse | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| 5 | 139 | 72 | 3H-5HT | -117 | 54 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-5HT | -117 | 54 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-5HT | -117 | 54 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-5HT | -117 | 54 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5 | 139 | 72 | 3H-GR-113808 | -154 | 54 | Mouse | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-GR-113808 | -154 | 54 | Mouse | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-GR-113808 | -154 | 54 | Mouse | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-GR-113808 | -154 | 54 | Mouse | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 240 | 944 | 43 | 3H-GR-113808 | -8 | 24 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 2769 | 944 | 43 | 3H-GR-113808 | -8 | 24 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 44279790 | 944 | 43 | 3H-GR-113808 | -8 | 24 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 660 | 944 | 43 | 3H-GR-113808 | -8 | 24 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| CHEMBL1729 | 944 | 43 | 3H-GR-113808 | -8 | 24 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| CHEMBL560739 | 944 | 43 | 3H-GR-113808 | -8 | 24 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| DB00604 | 944 | 43 | 3H-GR-113808 | -8 | 24 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| None | 216011 | 0 | 3H-5HT | -2 | 5 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 367 | 2 | 1 | 6 | 2.4 | CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl | None | |||
| 108182 | 4131 | 22 | 3H-GR-113808 | -1 | 16 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 108182 | 4131 | 22 | 3H-RS 57639 | -1 | 16 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 245 | 4131 | 22 | 3H-GR-113808 | -1 | 16 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 245 | 4131 | 22 | 3H-RS 57639 | -1 | 16 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| CHEMBL18041 | 4131 | 22 | 3H-GR-113808 | -1 | 16 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| CHEMBL18041 | 4131 | 22 | 3H-RS 57639 | -1 | 16 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 240 | 944 | 43 | None | -8 | 24 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 2769 | 944 | 43 | None | -8 | 24 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 44279790 | 944 | 43 | None | -8 | 24 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 660 | 944 | 43 | None | -8 | 24 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| CHEMBL1729 | 944 | 43 | None | -8 | 24 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| CHEMBL560739 | 944 | 43 | None | -8 | 24 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| DB00604 | 944 | 43 | None | -8 | 24 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
| 135526515 | 217725 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 301 | 7 | 4 | 3 | 2.8 | CCCCCNC(=N)NN=CC1=CNC2=C1C=C(OC)C=C2 | None | |||
| 243 | 3202 | 91 | None | 12 | 34 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | |||
| 3052762 | 3202 | 91 | None | 12 | 34 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | |||
| 3502 | 3202 | 91 | None | 12 | 34 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | |||
| CHEMBL117287 | 3202 | 91 | None | 12 | 34 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | |||
| DB06480 | 3202 | 91 | None | 12 | 34 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | |||
| 108182 | 4131 | 22 | 3H-GR-113808 | -1 | 16 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 245 | 4131 | 22 | 3H-GR-113808 | -1 | 16 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| CHEMBL18041 | 4131 | 22 | 3H-GR-113808 | -1 | 16 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 57174031 | 215940 | 0 | 3H-GR-113808 | -8 | 19 | Mouse | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | |||
| 1782 | 2518 | 84 | 3H-GR-113808 | -25 | 22 | Mouse | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| 241 | 2518 | 84 | 3H-GR-113808 | -25 | 22 | Mouse | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| 4168 | 2518 | 84 | 3H-GR-113808 | -25 | 22 | Mouse | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| CHEMBL86 | 2518 | 84 | 3H-GR-113808 | -25 | 22 | Mouse | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| DB01233 | 2518 | 84 | 3H-GR-113808 | -25 | 22 | Mouse | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | |||
| 1809 | 134 | 32 | 3H-GR-113808 | -46773 | 36 | Rat | 5.0 | pKi | = | 5.0 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-GR-113808 | -46773 | 36 | Rat | 5.0 | pKi | = | 5.0 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-GR-113808 | -46773 | 36 | Rat | 5.0 | pKi | = | 5.0 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 3035240 | 215978 | 0 | 3H-GR-113808 | -1 | 4 | Mouse | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 359 | 3 | 2 | 4 | 2.6 | COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl | None | |||
| 1809 | 134 | 32 | 3H-GR-113808 | -109647 | 36 | Mouse | 5.0 | pKi | = | 5.0 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-GR-113808 | -109647 | 36 | Mouse | 5.0 | pKi | = | 5.0 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-GR-113808 | -109647 | 36 | Mouse | 5.0 | pKi | = | 5.0 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 57174031 | 215940 | 0 | 3H-ZACOPRIDE | -33 | 19 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | |||
| 53354764 | 3064 | 34 | None | 1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 22974325 | |||
| 9059 | 3064 | 34 | None | 1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 22974325 | |||
| CHEMBL2152922 | 3064 | 34 | None | 1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 22974325 | |||
| DB12675 | 3064 | 34 | None | 1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 22974325 | |||
| 121881 | 3490 | 27 | None | 11 | 14 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10646498 | |||
| 121881 | 3490 | 27 | None | 11 | 14 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10683202 | |||
| 121881 | 3490 | 27 | None | 11 | 14 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 11030734 | |||
| 121881 | 3490 | 27 | None | 11 | 14 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 9349523 | |||
| 256 | 3490 | 27 | None | 11 | 14 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10646498 | |||
| 256 | 3490 | 27 | None | 11 | 14 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10683202 | |||
| 256 | 3490 | 27 | None | 11 | 14 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 11030734 | |||
| 256 | 3490 | 27 | None | 11 | 14 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 9349523 | |||
| CHEMBL68131 | 3490 | 27 | None | 11 | 14 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10646498 | |||
| CHEMBL68131 | 3490 | 27 | None | 11 | 14 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10683202 | |||
| CHEMBL68131 | 3490 | 27 | None | 11 | 14 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 11030734 | |||
| CHEMBL68131 | 3490 | 27 | None | 11 | 14 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 9349523 | |||
| 250 | 3386 | 8 | None | 2818 | 12 | Human | 10.5 | pKi | = | 10.5 | Binding | Guide to Pharmacology | 502 | 10 | 1 | 7 | 5.0 | COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC | 15351779 | |||
| 250 | 3386 | 8 | None | 2818 | 12 | Human | 10.5 | pKi | = | 10.5 | Binding | Guide to Pharmacology | 502 | 10 | 1 | 7 | 5.0 | COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC | 9351641 | |||
| 5311416 | 3386 | 8 | None | 2818 | 12 | Human | 10.5 | pKi | = | 10.5 | Binding | Guide to Pharmacology | 502 | 10 | 1 | 7 | 5.0 | COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC | 15351779 | |||
| 5311416 | 3386 | 8 | None | 2818 | 12 | Human | 10.5 | pKi | = | 10.5 | Binding | Guide to Pharmacology | 502 | 10 | 1 | 7 | 5.0 | COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC | 9351641 | |||
| CHEMBL69733 | 3386 | 8 | None | 2818 | 12 | Human | 10.5 | pKi | = | 10.5 | Binding | Guide to Pharmacology | 502 | 10 | 1 | 7 | 5.0 | COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC | 15351779 | |||
| CHEMBL69733 | 3386 | 8 | None | 2818 | 12 | Human | 10.5 | pKi | = | 10.5 | Binding | Guide to Pharmacology | 502 | 10 | 1 | 7 | 5.0 | COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC | 9351641 | |||
| 1782 | 2518 | 84 | None | -25 | 22 | Mouse | 6.0 | pKi | = | 6 | Binding | Guide to Pharmacology | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 8946946 | |||
| 241 | 2518 | 84 | None | -25 | 22 | Mouse | 6.0 | pKi | = | 6 | Binding | Guide to Pharmacology | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 8946946 | |||
| 4168 | 2518 | 84 | None | -25 | 22 | Mouse | 6.0 | pKi | = | 6 | Binding | Guide to Pharmacology | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 8946946 | |||
| CHEMBL86 | 2518 | 84 | None | -25 | 22 | Mouse | 6.0 | pKi | = | 6 | Binding | Guide to Pharmacology | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 8946946 | |||
| DB01233 | 2518 | 84 | None | -25 | 22 | Mouse | 6.0 | pKi | = | 6 | Binding | Guide to Pharmacology | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 8946946 | |||
| 240 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10646498 | |||
| 240 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10683202 | |||
| 240 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 11030734 | |||
| 240 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 11218067 | |||
| 240 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 7796807 | |||
| 240 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 9349523 | |||
| 2769 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10646498 | |||
| 2769 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10683202 | |||
| 2769 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 11030734 | |||
| 2769 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 11218067 | |||
| 2769 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 7796807 | |||
| 2769 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 9349523 | |||
| 44279790 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10646498 | |||
| 44279790 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10683202 | |||
| 44279790 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 11030734 | |||
| 44279790 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 11218067 | |||
| 44279790 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 7796807 | |||
| 44279790 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 9349523 | |||
| 660 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10646498 | |||
| 660 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10683202 | |||
| 660 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 11030734 | |||
| 660 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 11218067 | |||
| 660 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 7796807 | |||
| 660 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 9349523 | |||
| CHEMBL1729 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10646498 | |||
| CHEMBL1729 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10683202 | |||
| CHEMBL1729 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 11030734 | |||
| CHEMBL1729 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 11218067 | |||
| CHEMBL1729 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 7796807 | |||
| CHEMBL1729 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 9349523 | |||
| CHEMBL560739 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10646498 | |||
| CHEMBL560739 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10683202 | |||
| CHEMBL560739 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 11030734 | |||
| CHEMBL560739 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 11218067 | |||
| CHEMBL560739 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 7796807 | |||
| CHEMBL560739 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 9349523 | |||
| DB00604 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10646498 | |||
| DB00604 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10683202 | |||
| DB00604 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 11030734 | |||
| DB00604 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 11218067 | |||
| DB00604 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 7796807 | |||
| DB00604 | 944 | 43 | None | -11 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 9349523 | |||
| 234 | 661 | 0 | None | -1 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 342 | 2 | 1 | 5 | 2.6 | CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)n1c(=O)n(c2c1cccc2)C(C)C | 9351641 | |||
| 5311029 | 661 | 0 | None | -1 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 342 | 2 | 1 | 5 | 2.6 | CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)n1c(=O)n(c2c1cccc2)C(C)C | 9351641 | |||
| 11842633 | 3981 | 21 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 18415081 | |||
| 11842633 | 3981 | 21 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 22959244 | |||
| 8425 | 3981 | 21 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 18415081 | |||
| 8425 | 3981 | 21 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 22959244 | |||
| CHEMBL2087337 | 3981 | 21 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 18415081 | |||
| CHEMBL2087337 | 3981 | 21 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 22959244 | |||
| 45275554 | 3312 | 0 | None | 6 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | 492 | 9 | 3 | 6 | 3.7 | COc1cc(N)c(cc1C(=O)NCC1CCN(CC1)CC[C@@H](c1ccc(cc1)F)OC(=O)N)Cl | 25316608 | |||
| 8427 | 3312 | 0 | None | 6 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | 492 | 9 | 3 | 6 | 3.7 | COc1cc(N)c(cc1C(=O)NCC1CCN(CC1)CC[C@@H](c1ccc(cc1)F)OC(=O)N)Cl | 25316608 | |||
| CHEMBL3544975 | 3312 | 0 | None | 6 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | 492 | 9 | 3 | 6 | 3.7 | COc1cc(N)c(cc1C(=O)NCC1CCN(CC1)CC[C@@H](c1ccc(cc1)F)OC(=O)N)Cl | 25316608 | |||
| DB12798 | 3312 | 0 | None | 6 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | 492 | 9 | 3 | 6 | 3.7 | COc1cc(N)c(cc1C(=O)NCC1CCN(CC1)CC[C@@H](c1ccc(cc1)F)OC(=O)N)Cl | 25316608 | |||
| 235 | 2564 | 42 | None | -4 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10683202 | |||
| 235 | 2564 | 42 | None | -4 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10821780 | |||
| 235 | 2564 | 42 | None | -4 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 11030734 | |||
| 235 | 2564 | 42 | None | -4 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 12801225 | |||
| 235 | 2564 | 42 | None | -4 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 9603189 | |||
| 5311299 | 2564 | 42 | None | -4 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10683202 | |||
| 5311299 | 2564 | 42 | None | -4 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10821780 | |||
| 5311299 | 2564 | 42 | None | -4 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 11030734 | |||
| 5311299 | 2564 | 42 | None | -4 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 12801225 | |||
| 5311299 | 2564 | 42 | None | -4 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 9603189 | |||
| CHEMBL286136 | 2564 | 42 | None | -4 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10683202 | |||
| CHEMBL286136 | 2564 | 42 | None | -4 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10821780 | |||
| CHEMBL286136 | 2564 | 42 | None | -4 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 11030734 | |||
| CHEMBL286136 | 2564 | 42 | None | -4 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 12801225 | |||
| CHEMBL286136 | 2564 | 42 | None | -4 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 9603189 | |||
| 11961293 | 3769 | 19 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 23756062 | |||
| 8426 | 3769 | 19 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 23756062 | |||
| CHEMBL2402904 | 3769 | 19 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 23756062 | |||
| DB12725 | 3769 | 19 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 23756062 | |||
| 119376 | 1841 | 48 | None | -1 | 26 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10646498 | |||
| 119376 | 1841 | 48 | None | -1 | 26 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 11030734 | |||
| 119376 | 1841 | 48 | None | -1 | 26 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 11218067 | |||
| 119376 | 1841 | 48 | None | -1 | 26 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 15351779 | |||
| 119376 | 1841 | 48 | None | -1 | 26 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 9349523 | |||
| 119376 | 1841 | 48 | None | -1 | 26 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 9351641 | |||
| 119376 | 1841 | 48 | None | -1 | 26 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 9603189 | |||
| 247 | 1841 | 48 | None | -1 | 26 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10646498 | |||
| 247 | 1841 | 48 | None | -1 | 26 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 11030734 | |||
| 247 | 1841 | 48 | None | -1 | 26 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 11218067 | |||
| 247 | 1841 | 48 | None | -1 | 26 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 15351779 | |||
| 247 | 1841 | 48 | None | -1 | 26 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 9349523 | |||
| 247 | 1841 | 48 | None | -1 | 26 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 9351641 | |||
| 247 | 1841 | 48 | None | -1 | 26 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 9603189 | |||
| CHEMBL33884 | 1841 | 48 | None | -1 | 26 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10646498 | |||
| CHEMBL33884 | 1841 | 48 | None | -1 | 26 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 11030734 | |||
| CHEMBL33884 | 1841 | 48 | None | -1 | 26 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 11218067 | |||
| CHEMBL33884 | 1841 | 48 | None | -1 | 26 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 15351779 | |||
| CHEMBL33884 | 1841 | 48 | None | -1 | 26 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 9349523 | |||
| CHEMBL33884 | 1841 | 48 | None | -1 | 26 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 9351641 | |||
| CHEMBL33884 | 1841 | 48 | None | -1 | 26 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 9603189 | |||
| 257 | 3493 | 13 | None | -1 | 3 | Human | 10.2 | pKi | None | 10.2 | Binding | Guide to Pharmacology | 474 | 6 | 1 | 6 | 3.3 | CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N | 11218067 | |||
| 5311423 | 3493 | 13 | None | -1 | 3 | Human | 10.2 | pKi | None | 10.2 | Binding | Guide to Pharmacology | 474 | 6 | 1 | 6 | 3.3 | CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N | 11218067 | |||
| CHEMBL114112 | 3493 | 13 | None | -1 | 3 | Human | 10.2 | pKi | None | 10.2 | Binding | Guide to Pharmacology | 474 | 6 | 1 | 6 | 3.3 | CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N | 11218067 | |||
| 248 | 1842 | 0 | None | -2 | 2 | Human | 10.3 | pKi | None | 10.3 | Binding | Guide to Pharmacology | 427 | 8 | 2 | 6 | 1.7 | COc1[nH]c2c(c1C(=O)OCC1CCN(CC1)CCNS(=O)(=O)C)cc(cc2)F | 9349523 | |||
| 248 | 1842 | 0 | None | -2 | 2 | Human | 10.3 | pKi | None | 10.3 | Binding | Guide to Pharmacology | 427 | 8 | 2 | 6 | 1.7 | COc1[nH]c2c(c1C(=O)OCC1CCN(CC1)CCNS(=O)(=O)C)cc(cc2)F | 9351641 | |||
| 4284721 | 1842 | 0 | None | -2 | 2 | Human | 10.3 | pKi | None | 10.3 | Binding | Guide to Pharmacology | 427 | 8 | 2 | 6 | 1.7 | COc1[nH]c2c(c1C(=O)OCC1CCN(CC1)CCNS(=O)(=O)C)cc(cc2)F | 9349523 | |||
| 4284721 | 1842 | 0 | None | -2 | 2 | Human | 10.3 | pKi | None | 10.3 | Binding | Guide to Pharmacology | 427 | 8 | 2 | 6 | 1.7 | COc1[nH]c2c(c1C(=O)OCC1CCN(CC1)CCNS(=O)(=O)C)cc(cc2)F | 9351641 | |||
| CHEMBL471233 | 1842 | 0 | None | -2 | 2 | Human | 10.3 | pKi | None | 10.3 | Binding | Guide to Pharmacology | 427 | 8 | 2 | 6 | 1.7 | COc1[nH]c2c(c1C(=O)OCC1CCN(CC1)CCNS(=O)(=O)C)cc(cc2)F | 9349523 | |||
| CHEMBL471233 | 1842 | 0 | None | -2 | 2 | Human | 10.3 | pKi | None | 10.3 | Binding | Guide to Pharmacology | 427 | 8 | 2 | 6 | 1.7 | COc1[nH]c2c(c1C(=O)OCC1CCN(CC1)CCNS(=O)(=O)C)cc(cc2)F | 9351641 | |||
| 248 | 1842 | 0 | None | 2 | 2 | Mouse | 10.6 | pKi | None | 10.6 | Binding | Guide to Pharmacology | 427 | 8 | 2 | 6 | 1.7 | COc1[nH]c2c(c1C(=O)OCC1CCN(CC1)CCNS(=O)(=O)C)cc(cc2)F | 8946946 | |||
| 4284721 | 1842 | 0 | None | 2 | 2 | Mouse | 10.6 | pKi | None | 10.6 | Binding | Guide to Pharmacology | 427 | 8 | 2 | 6 | 1.7 | COc1[nH]c2c(c1C(=O)OCC1CCN(CC1)CCNS(=O)(=O)C)cc(cc2)F | 8946946 | |||
| CHEMBL471233 | 1842 | 0 | None | 2 | 2 | Mouse | 10.6 | pKi | None | 10.6 | Binding | Guide to Pharmacology | 427 | 8 | 2 | 6 | 1.7 | COc1[nH]c2c(c1C(=O)OCC1CCN(CC1)CCNS(=O)(=O)C)cc(cc2)F | 8946946 | |||
| 108182 | 4131 | 22 | None | -2 | 16 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 7796807 | |||
| 108182 | 4131 | 22 | None | -2 | 16 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 9351641 | |||
| 108182 | 4131 | 22 | None | -2 | 16 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 9603189 | |||
| 245 | 4131 | 22 | None | -2 | 16 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 7796807 | |||
| 245 | 4131 | 22 | None | -2 | 16 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 9351641 | |||
| 245 | 4131 | 22 | None | -2 | 16 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 9603189 | |||
| CHEMBL18041 | 4131 | 22 | None | -2 | 16 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 7796807 | |||
| CHEMBL18041 | 4131 | 22 | None | -2 | 16 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 9351641 | |||
| CHEMBL18041 | 4131 | 22 | None | -2 | 16 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 9603189 | |||
| 152 | 364 | 29 | None | -208 | 18 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 15466450 | |||
| 152 | 364 | 29 | None | -208 | 18 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 7796807 | |||
| 2107 | 364 | 29 | None | -208 | 18 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 15466450 | |||
| 2107 | 364 | 29 | None | -208 | 18 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 7796807 | |||
| CHEMBL275854 | 364 | 29 | None | -208 | 18 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 15466450 | |||
| CHEMBL275854 | 364 | 29 | None | -208 | 18 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 7796807 | |||
| 152 | 364 | 29 | None | -89 | 18 | Rat | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 8813606 | |||
| 152 | 364 | 29 | None | -89 | 18 | Rat | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 9225293 | |||
| 2107 | 364 | 29 | None | -89 | 18 | Rat | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 8813606 | |||
| 2107 | 364 | 29 | None | -89 | 18 | Rat | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 9225293 | |||
| CHEMBL275854 | 364 | 29 | None | -89 | 18 | Rat | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 8813606 | |||
| CHEMBL275854 | 364 | 29 | None | -89 | 18 | Rat | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 9225293 | |||
| 107 | 141 | 121 | None | -389 | 30 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10646498 | |||
| 107 | 141 | 121 | None | -389 | 30 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10683202 | |||
| 107 | 141 | 121 | None | -389 | 30 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 11030734 | |||
| 107 | 141 | 121 | None | -389 | 30 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 11218067 | |||
| 107 | 141 | 121 | None | -389 | 30 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 9349523 | |||
| 107 | 141 | 121 | None | -389 | 30 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 9603189 | |||
| 1833 | 141 | 121 | None | -389 | 30 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10646498 | |||
| 1833 | 141 | 121 | None | -389 | 30 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10683202 | |||
| 1833 | 141 | 121 | None | -389 | 30 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 11030734 | |||
| 1833 | 141 | 121 | None | -389 | 30 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 11218067 | |||
| 1833 | 141 | 121 | None | -389 | 30 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 9349523 | |||
| 1833 | 141 | 121 | None | -389 | 30 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 9603189 | |||
| CHEMBL8165 | 141 | 121 | None | -389 | 30 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10646498 | |||
| CHEMBL8165 | 141 | 121 | None | -389 | 30 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10683202 | |||
| CHEMBL8165 | 141 | 121 | None | -389 | 30 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 11030734 | |||
| CHEMBL8165 | 141 | 121 | None | -389 | 30 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 11218067 | |||
| CHEMBL8165 | 141 | 121 | None | -389 | 30 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 9349523 | |||
| CHEMBL8165 | 141 | 121 | None | -389 | 30 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 9603189 | |||
| 244 | 3314 | 0 | None | -5 | 3 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 10683202 | |||
| 244 | 3314 | 0 | None | -5 | 3 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 11030734 | |||
| 244 | 3314 | 0 | None | -5 | 3 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 11218067 | |||
| 244 | 3314 | 0 | None | -5 | 3 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 7796807 | |||
| 244 | 3314 | 0 | None | -5 | 3 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 9351641 | |||
| 244 | 3314 | 0 | None | -5 | 3 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 9603189 | |||
| 3086547 | 3314 | 0 | None | -5 | 3 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 10683202 | |||
| 3086547 | 3314 | 0 | None | -5 | 3 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 11030734 | |||
| 3086547 | 3314 | 0 | None | -5 | 3 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 11218067 | |||
| 3086547 | 3314 | 0 | None | -5 | 3 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 7796807 | |||
| 3086547 | 3314 | 0 | None | -5 | 3 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 9351641 | |||
| 3086547 | 3314 | 0 | None | -5 | 3 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 9603189 | |||
| 108182 | 4131 | 22 | None | -1 | 16 | Rat | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 8813606 | |||
| 108182 | 4131 | 22 | None | -1 | 16 | Rat | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 9225293 | |||
| 245 | 4131 | 22 | None | -1 | 16 | Rat | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 8813606 | |||
| 245 | 4131 | 22 | None | -1 | 16 | Rat | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 9225293 | |||
| CHEMBL18041 | 4131 | 22 | None | -1 | 16 | Rat | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 8813606 | |||
| CHEMBL18041 | 4131 | 22 | None | -1 | 16 | Rat | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 9225293 | |||
| 5 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10646498 | |||
| 5 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10683202 | |||
| 5 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10821780 | |||
| 5 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 11030734 | |||
| 5 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 11218067 | |||
| 5 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 15351779 | |||
| 5 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 15466450 | |||
| 5 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9349523 | |||
| 5 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9351641 | |||
| 5 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9603189 | |||
| 5202 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10646498 | |||
| 5202 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10683202 | |||
| 5202 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10821780 | |||
| 5202 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 11030734 | |||
| 5202 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 11218067 | |||
| 5202 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 15351779 | |||
| 5202 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 15466450 | |||
| 5202 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9349523 | |||
| 5202 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9351641 | |||
| 5202 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9603189 | |||
| CHEMBL39 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10646498 | |||
| CHEMBL39 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10683202 | |||
| CHEMBL39 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10821780 | |||
| CHEMBL39 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 11030734 | |||
| CHEMBL39 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 11218067 | |||
| CHEMBL39 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 15351779 | |||
| CHEMBL39 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 15466450 | |||
| CHEMBL39 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9349523 | |||
| CHEMBL39 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9351641 | |||
| CHEMBL39 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9603189 | |||
| DB08839 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10646498 | |||
| DB08839 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10683202 | |||
| DB08839 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10821780 | |||
| DB08839 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 11030734 | |||
| DB08839 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 11218067 | |||
| DB08839 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 15351779 | |||
| DB08839 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 15466450 | |||
| DB08839 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9349523 | |||
| DB08839 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9351641 | |||
| DB08839 | 139 | 72 | None | -288 | 54 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9603189 | |||
| 119584 | 2595 | 102 | None | -1 | 5 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | 10646498 | |||
| 1848 | 2595 | 102 | None | -1 | 5 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | 10646498 | |||
| 242 | 2595 | 102 | None | -1 | 5 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | 10646498 | |||
| CHEMBL60889 | 2595 | 102 | None | -1 | 5 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | 10646498 | |||
| DB11675 | 2595 | 102 | None | -1 | 5 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | 10646498 | |||
| 107 | 141 | 121 | None | -457 | 30 | Mouse | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 8946946 | |||
| 1833 | 141 | 121 | None | -457 | 30 | Mouse | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 8946946 | |||
| CHEMBL8165 | 141 | 121 | None | -457 | 30 | Mouse | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 8946946 | |||
| 260 | 3869 | 54 | None | -38 | 5 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 11218067 | |||
| 260 | 3869 | 54 | None | -38 | 5 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 9349523 | |||
| 2775 | 3869 | 54 | None | -38 | 5 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 11218067 | |||
| 2775 | 3869 | 54 | None | -38 | 5 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 9349523 | |||
| 656665 | 3869 | 54 | None | -38 | 5 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 11218067 | |||
| 656665 | 3869 | 54 | None | -38 | 5 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 9349523 | |||
| CHEMBL56564 | 3869 | 54 | None | -38 | 5 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 11218067 | |||
| CHEMBL56564 | 3869 | 54 | None | -38 | 5 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 9349523 | |||
| DB11699 | 3869 | 54 | None | -38 | 5 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 11218067 | |||
| DB11699 | 3869 | 54 | None | -38 | 5 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 9349523 | |||
| 108182 | 4131 | 22 | None | 1 | 16 | Mouse | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 8946946 | |||
| 245 | 4131 | 22 | None | 1 | 16 | Mouse | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 8946946 | |||
| CHEMBL18041 | 4131 | 22 | None | 1 | 16 | Mouse | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 8946946 | |||
| 260 | 3869 | 54 | None | -19 | 5 | Rat | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 8813606 | |||
| 2775 | 3869 | 54 | None | -19 | 5 | Rat | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 8813606 | |||
| 656665 | 3869 | 54 | None | -19 | 5 | Rat | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 8813606 | |||
| CHEMBL56564 | 3869 | 54 | None | -19 | 5 | Rat | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 8813606 | |||
| DB11699 | 3869 | 54 | None | -19 | 5 | Rat | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 8813606 | |||
| 107 | 141 | 121 | None | -257 | 30 | Rat | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 7796807 | |||
| 107 | 141 | 121 | None | -257 | 30 | Rat | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 8813606 | |||
| 107 | 141 | 121 | None | -257 | 30 | Rat | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 9225293 | |||
| 1833 | 141 | 121 | None | -257 | 30 | Rat | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 7796807 | |||
| 1833 | 141 | 121 | None | -257 | 30 | Rat | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 8813606 | |||
| 1833 | 141 | 121 | None | -257 | 30 | Rat | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 9225293 | |||
| CHEMBL8165 | 141 | 121 | None | -257 | 30 | Rat | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 7796807 | |||
| CHEMBL8165 | 141 | 121 | None | -257 | 30 | Rat | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 8813606 | |||
| CHEMBL8165 | 141 | 121 | None | -257 | 30 | Rat | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 9225293 | |||
| 244 | 3314 | 0 | None | -1 | 3 | Mouse | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 8946946 | |||
| 3086547 | 3314 | 0 | None | -1 | 3 | Mouse | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 8946946 | |||
| 244 | 3314 | 0 | None | 1 | 3 | Rat | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 8813606 | |||
| 244 | 3314 | 0 | None | 1 | 3 | Rat | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 9225293 | |||
| 3086547 | 3314 | 0 | None | 1 | 3 | Rat | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 8813606 | |||
| 3086547 | 3314 | 0 | None | 1 | 3 | Rat | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 9225293 | |||
| 260 | 3869 | 54 | None | -15 | 5 | Mouse | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 8946946 | |||
| 2775 | 3869 | 54 | None | -15 | 5 | Mouse | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 8946946 | |||
| 656665 | 3869 | 54 | None | -15 | 5 | Mouse | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 8946946 | |||
| CHEMBL56564 | 3869 | 54 | None | -15 | 5 | Mouse | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 8946946 | |||
| DB11699 | 3869 | 54 | None | -15 | 5 | Mouse | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 8946946 | |||
| 5 | 139 | 72 | None | -154 | 54 | Mouse | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8946946 | |||
| 5202 | 139 | 72 | None | -154 | 54 | Mouse | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8946946 | |||
| CHEMBL39 | 139 | 72 | None | -154 | 54 | Mouse | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8946946 | |||
| DB08839 | 139 | 72 | None | -154 | 54 | Mouse | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8946946 | |||
| 129928 | 1329 | 0 | None | -5 | 2 | Mouse | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 331 | 2 | 1 | 6 | 1.9 | COc1ccc2c(c1)n(C(=O)OC1CC3CCC(C1)N3C)c(=O)[nH]2 | 8946946 | |||
| 246 | 1329 | 0 | None | -5 | 2 | Mouse | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 331 | 2 | 1 | 6 | 1.9 | COc1ccc2c(c1)n(C(=O)OC1CC3CCC(C1)N3C)c(=O)[nH]2 | 8946946 | |||
| CHEMBL1194556 | 1329 | 0 | None | -5 | 2 | Mouse | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 331 | 2 | 1 | 6 | 1.9 | COc1ccc2c(c1)n(C(=O)OC1CC3CCC(C1)N3C)c(=O)[nH]2 | 8946946 | |||
| 233 | 660 | 0 | None | -1 | 2 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 328 | 2 | 1 | 5 | 2.0 | CCn1c(=O)n(c2c1cccc2)C(=O)NC1CC2CC[C@@H](C1)N2C | 10683202 | |||
| 233 | 660 | 0 | None | -1 | 2 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 328 | 2 | 1 | 5 | 2.0 | CCn1c(=O)n(c2c1cccc2)C(=O)NC1CC2CC[C@@H](C1)N2C | 11030734 | |||
| 233 | 660 | 0 | None | -1 | 2 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 328 | 2 | 1 | 5 | 2.0 | CCn1c(=O)n(c2c1cccc2)C(=O)NC1CC2CC[C@@H](C1)N2C | 9603189 | |||
| 9929033 | 660 | 0 | None | -1 | 2 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 328 | 2 | 1 | 5 | 2.0 | CCn1c(=O)n(c2c1cccc2)C(=O)NC1CC2CC[C@@H](C1)N2C | 10683202 | |||
| 9929033 | 660 | 0 | None | -1 | 2 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 328 | 2 | 1 | 5 | 2.0 | CCn1c(=O)n(c2c1cccc2)C(=O)NC1CC2CC[C@@H](C1)N2C | 11030734 | |||
| 9929033 | 660 | 0 | None | -1 | 2 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 328 | 2 | 1 | 5 | 2.0 | CCn1c(=O)n(c2c1cccc2)C(=O)NC1CC2CC[C@@H](C1)N2C | 9603189 | |||
| 240 | 944 | 43 | None | -8 | 24 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 8813606 | |||
| 240 | 944 | 43 | None | -8 | 24 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 9225293 | |||
| 2769 | 944 | 43 | None | -8 | 24 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 8813606 | |||
| 2769 | 944 | 43 | None | -8 | 24 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 9225293 | |||
| 44279790 | 944 | 43 | None | -8 | 24 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 8813606 | |||
| 44279790 | 944 | 43 | None | -8 | 24 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 9225293 | |||
| 660 | 944 | 43 | None | -8 | 24 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 8813606 | |||
| 660 | 944 | 43 | None | -8 | 24 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 9225293 | |||
| CHEMBL1729 | 944 | 43 | None | -8 | 24 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 8813606 | |||
| CHEMBL1729 | 944 | 43 | None | -8 | 24 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 9225293 | |||
| CHEMBL560739 | 944 | 43 | None | -8 | 24 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 8813606 | |||
| CHEMBL560739 | 944 | 43 | None | -8 | 24 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 9225293 | |||
| DB00604 | 944 | 43 | None | -8 | 24 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 8813606 | |||
| DB00604 | 944 | 43 | None | -8 | 24 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 9225293 | |||
| 234 | 661 | 0 | None | -1 | 3 | Mouse | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 342 | 2 | 1 | 5 | 2.6 | CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)n1c(=O)n(c2c1cccc2)C(C)C | 8946946 | |||
| 5311029 | 661 | 0 | None | -1 | 3 | Mouse | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 342 | 2 | 1 | 5 | 2.6 | CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)n1c(=O)n(c2c1cccc2)C(C)C | 8946946 | |||
| 5 | 139 | 72 | None | -117 | 54 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 7796807 | |||
| 5 | 139 | 72 | None | -117 | 54 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8813606 | |||
| 5 | 139 | 72 | None | -117 | 54 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9225293 | |||
| 5202 | 139 | 72 | None | -117 | 54 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 7796807 | |||
| 5202 | 139 | 72 | None | -117 | 54 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8813606 | |||
| 5202 | 139 | 72 | None | -117 | 54 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9225293 | |||
| CHEMBL39 | 139 | 72 | None | -117 | 54 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 7796807 | |||
| CHEMBL39 | 139 | 72 | None | -117 | 54 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8813606 | |||
| CHEMBL39 | 139 | 72 | None | -117 | 54 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9225293 | |||
| DB08839 | 139 | 72 | None | -117 | 54 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 7796807 | |||
| DB08839 | 139 | 72 | None | -117 | 54 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8813606 | |||
| DB08839 | 139 | 72 | None | -117 | 54 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9225293 | |||
| 234 | 661 | 0 | None | 1 | 3 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 342 | 2 | 1 | 5 | 2.6 | CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)n1c(=O)n(c2c1cccc2)C(C)C | 9225293 | |||
| 5311029 | 661 | 0 | None | 1 | 3 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 342 | 2 | 1 | 5 | 2.6 | CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)n1c(=O)n(c2c1cccc2)C(C)C | 9225293 | |||
| 233 | 660 | 0 | None | 1 | 2 | Mouse | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 328 | 2 | 1 | 5 | 2.0 | CCn1c(=O)n(c2c1cccc2)C(=O)NC1CC2CC[C@@H](C1)N2C | 8946946 | |||
| 9929033 | 660 | 0 | None | 1 | 2 | Mouse | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 328 | 2 | 1 | 5 | 2.0 | CCn1c(=O)n(c2c1cccc2)C(=O)NC1CC2CC[C@@H](C1)N2C | 8946946 | |||
| 240 | 944 | 43 | None | -5 | 24 | Mouse | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 8946946 | |||
| 2769 | 944 | 43 | None | -5 | 24 | Mouse | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 8946946 | |||
| 44279790 | 944 | 43 | None | -5 | 24 | Mouse | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 8946946 | |||
| 660 | 944 | 43 | None | -5 | 24 | Mouse | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 8946946 | |||
| CHEMBL1729 | 944 | 43 | None | -5 | 24 | Mouse | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 8946946 | |||
| CHEMBL560739 | 944 | 43 | None | -5 | 24 | Mouse | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 8946946 | |||
| DB00604 | 944 | 43 | None | -5 | 24 | Mouse | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 8946946 | |||
| 258 | 3567 | 31 | None | -1 | 7 | Rat | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 9225293 | |||
| 5191 | 3567 | 31 | None | -1 | 7 | Rat | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 9225293 | |||
| CHEMBL287045 | 3567 | 31 | None | -1 | 7 | Rat | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 9225293 | |||
| 243 | 3202 | 91 | None | 12 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10646498 | |||
| 243 | 3202 | 91 | None | 12 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 11438309 | |||
| 3052762 | 3202 | 91 | None | 12 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10646498 | |||
| 3052762 | 3202 | 91 | None | 12 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 11438309 | |||
| 3502 | 3202 | 91 | None | 12 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10646498 | |||
| 3502 | 3202 | 91 | None | 12 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 11438309 | |||
| CHEMBL117287 | 3202 | 91 | None | 12 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10646498 | |||
| CHEMBL117287 | 3202 | 91 | None | 12 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 11438309 | |||
| DB06480 | 3202 | 91 | None | 12 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10646498 | |||
| DB06480 | 3202 | 91 | None | 12 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 11438309 | |||
| 135409453 | 3773 | 41 | None | -2 | 2 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10646498 | |||
| 135409453 | 3773 | 41 | None | -2 | 2 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 15466450 | |||
| 226 | 3773 | 41 | None | -2 | 2 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10646498 | |||
| 226 | 3773 | 41 | None | -2 | 2 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 15466450 | |||
| CHEMBL76370 | 3773 | 41 | None | -2 | 2 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10646498 | |||
| CHEMBL76370 | 3773 | 41 | None | -2 | 2 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 15466450 | |||
| 129928 | 1329 | 0 | None | 5 | 2 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 331 | 2 | 1 | 6 | 1.9 | COc1ccc2c(c1)n(C(=O)OC1CC3CCC(C1)N3C)c(=O)[nH]2 | 9351641 | |||
| 246 | 1329 | 0 | None | 5 | 2 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 331 | 2 | 1 | 6 | 1.9 | COc1ccc2c(c1)n(C(=O)OC1CC3CCC(C1)N3C)c(=O)[nH]2 | 9351641 | |||
| CHEMBL1194556 | 1329 | 0 | None | 5 | 2 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 331 | 2 | 1 | 6 | 1.9 | COc1ccc2c(c1)n(C(=O)OC1CC3CCC(C1)N3C)c(=O)[nH]2 | 9351641 | |||
| 132337 | 3543 | 15 | None | - | 1 | Mouse | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 8946946 | |||
| 238 | 3543 | 15 | None | - | 1 | Mouse | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 8946946 | |||
| CHEMBL34291 | 3543 | 15 | None | - | 1 | Mouse | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 8946946 | |||
| 258 | 3567 | 31 | None | -1 | 7 | Mouse | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 7498967 | |||
| 5191 | 3567 | 31 | None | -1 | 7 | Mouse | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 7498967 | |||
| CHEMBL287045 | 3567 | 31 | None | -1 | 7 | Mouse | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 7498967 | |||
| 182593 | 3395 | 6 | None | 2 | 2 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10683202 | |||
| 182593 | 3395 | 6 | None | 2 | 2 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 11030734 | |||
| 182593 | 3395 | 6 | None | 2 | 2 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 15351779 | |||
| 254 | 3395 | 6 | None | 2 | 2 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10683202 | |||
| 254 | 3395 | 6 | None | 2 | 2 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 11030734 | |||
| 254 | 3395 | 6 | None | 2 | 2 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 15351779 | |||
| CHEMBL83954 | 3395 | 6 | None | 2 | 2 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10683202 | |||
| CHEMBL83954 | 3395 | 6 | None | 2 | 2 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 11030734 | |||
| CHEMBL83954 | 3395 | 6 | None | 2 | 2 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 15351779 | |||
| 183782 | 3398 | 20 | None | 69 | 13 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10683202 | |||
| 183782 | 3398 | 20 | None | 69 | 13 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 11030734 | |||
| 237 | 3398 | 20 | None | 69 | 13 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10683202 | |||
| 237 | 3398 | 20 | None | 69 | 13 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 11030734 | |||
| CHEMBL85251 | 3398 | 20 | None | 69 | 13 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10683202 | |||
| CHEMBL85251 | 3398 | 20 | None | 69 | 13 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 11030734 | |||
| 119376 | 1841 | 48 | None | -2 | 26 | Rat | 8.6 | pKi | None | 8.6 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 9225293 | |||
| 247 | 1841 | 48 | None | -2 | 26 | Rat | 8.6 | pKi | None | 8.6 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 9225293 | |||
| CHEMBL33884 | 1841 | 48 | None | -2 | 26 | Rat | 8.6 | pKi | None | 8.6 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 9225293 | |||
| 236 | 3397 | 0 | None | - | 1 | Rat | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | 474 | 8 | 1 | 7 | 4.2 | COc1cc(N)c(cc1C(=O)OCC1CCN(CC1)CCCc1ccc2c(c1)OCCO2)Cl | 9225293 | |||
| 239 | 3397 | 0 | None | - | 1 | Rat | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | 474 | 8 | 1 | 7 | 4.2 | COc1cc(N)c(cc1C(=O)OCC1CCN(CC1)CCCc1ccc2c(c1)OCCO2)Cl | 9225293 | |||
| 5311417 | 3397 | 0 | None | - | 1 | Rat | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | 474 | 8 | 1 | 7 | 4.2 | COc1cc(N)c(cc1C(=O)OCC1CCN(CC1)CCCc1ccc2c(c1)OCCO2)Cl | 9225293 | |||
| CHEMBL1908857 | 3397 | 0 | None | - | 1 | Rat | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | 474 | 8 | 1 | 7 | 4.2 | COc1cc(N)c(cc1C(=O)OCC1CCN(CC1)CCCc1ccc2c(c1)OCCO2)Cl | 9225293 | |||
| 255 | 3489 | 21 | None | - | 1 | Human | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | 272 | 4 | 1 | 3 | 2.8 | O=C(c1c[nH]c2c1cccc2)OCCN1CCCCC1 | 11218067 | |||
| 3272300 | 3489 | 21 | None | - | 1 | Human | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | 272 | 4 | 1 | 3 | 2.8 | O=C(c1c[nH]c2c1cccc2)OCCN1CCCCC1 | 11218067 | |||
| CHEMBL1255781 | 3489 | 21 | None | - | 1 | Human | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | 272 | 4 | 1 | 3 | 2.8 | O=C(c1c[nH]c2c1cccc2)OCCN1CCCCC1 | 11218067 | |||
| 121881 | 3490 | 27 | None | -11 | 14 | Rat | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 9225293 | |||
| 256 | 3490 | 27 | None | -11 | 14 | Rat | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 9225293 | |||
| CHEMBL68131 | 3490 | 27 | None | -11 | 14 | Rat | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 9225293 | |||
| 29 | 792 | 0 | None | 1584 | 9 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 456 | 5 | 1 | 8 | 3.4 | Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1 | 12130738 | |||
| 9805719 | 792 | 0 | None | 1584 | 9 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 456 | 5 | 1 | 8 | 3.4 | Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1 | 12130738 | |||
| CHEMBL2027925 | 792 | 0 | None | 1584 | 9 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 456 | 5 | 1 | 8 | 3.4 | Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1 | 12130738 | |||
| 252 | 3342 | 3 | None | 1 | 2 | Mouse | 9.3 | pKi | None | 9.3 | Binding | Guide to Pharmacology | 332 | 6 | 1 | 4 | 2.7 | CCCCN1CCC(CC1)CNC(=O)c1cccc2c1OCCO2 | 11976337 | |||
| 44391713 | 3342 | 3 | None | 1 | 2 | Mouse | 9.3 | pKi | None | 9.3 | Binding | Guide to Pharmacology | 332 | 6 | 1 | 4 | 2.7 | CCCCN1CCC(CC1)CNC(=O)c1cccc2c1OCCO2 | 11976337 | |||
| CHEMBL182590 | 3342 | 3 | None | 1 | 2 | Mouse | 9.3 | pKi | None | 9.3 | Binding | Guide to Pharmacology | 332 | 6 | 1 | 4 | 2.7 | CCCCN1CCC(CC1)CNC(=O)c1cccc2c1OCCO2 | 11976337 | |||
| 249 | 2565 | 4 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10683202 | |||
| 249 | 2565 | 4 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10821780 | |||
| 249 | 2565 | 4 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 11030734 | |||
| 249 | 2565 | 4 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 15466450 | |||
| 249 | 2565 | 4 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 9603189 | |||
| 9905972 | 2565 | 4 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10683202 | |||
| 9905972 | 2565 | 4 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10821780 | |||
| 9905972 | 2565 | 4 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 11030734 | |||
| 9905972 | 2565 | 4 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 15466450 | |||
| 9905972 | 2565 | 4 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 9603189 | |||
| CHEMBL155917 | 2565 | 4 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10683202 | |||
| CHEMBL155917 | 2565 | 4 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10821780 | |||
| CHEMBL155917 | 2565 | 4 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 11030734 | |||
| CHEMBL155917 | 2565 | 4 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 15466450 | |||
| CHEMBL155917 | 2565 | 4 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 9603189 | |||
| 10404587 | 3390 | 5 | None | - | 1 | Mouse | 9.5 | pKi | None | 9.5 | Binding | Guide to Pharmacology | 333 | 6 | 0 | 5 | 3.1 | CCCCN1CCC(CC1)COC(=O)c1cccc2c1OCCO2 | 11976337 | |||
| 251 | 3390 | 5 | None | - | 1 | Mouse | 9.5 | pKi | None | 9.5 | Binding | Guide to Pharmacology | 333 | 6 | 0 | 5 | 3.1 | CCCCN1CCC(CC1)COC(=O)c1cccc2c1OCCO2 | 11976337 | |||
| CHEMBL130040 | 3390 | 5 | None | - | 1 | Mouse | 9.5 | pKi | None | 9.5 | Binding | Guide to Pharmacology | 333 | 6 | 0 | 5 | 3.1 | CCCCN1CCC(CC1)COC(=O)c1cccc2c1OCCO2 | 11976337 | |||
| 177336 | 3120 | 50 | None | 1412 | 2 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 11504648 | |||
| 177336 | 3120 | 50 | None | 1412 | 2 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 15466450 | |||
| 177336 | 3120 | 50 | None | 1412 | 2 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 9351641 | |||
| 225 | 3120 | 50 | None | 1412 | 2 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 11504648 | |||
| 225 | 3120 | 50 | None | 1412 | 2 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 15466450 | |||
| 225 | 3120 | 50 | None | 1412 | 2 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 9351641 | |||
| CHEMBL356359 | 3120 | 50 | None | 1412 | 2 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 11504648 | |||
| CHEMBL356359 | 3120 | 50 | None | 1412 | 2 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 15466450 | |||
| CHEMBL356359 | 3120 | 50 | None | 1412 | 2 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 9351641 | |||
| DB04873 | 3120 | 50 | None | 1412 | 2 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 11504648 | |||
| DB04873 | 3120 | 50 | None | 1412 | 2 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 15466450 | |||
| DB04873 | 3120 | 50 | None | 1412 | 2 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 9351641 | |||
| 119376 | 1841 | 48 | None | 1 | 26 | Mouse | 9.7 | pKi | None | 9.7 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 8946946 | |||
| 247 | 1841 | 48 | None | 1 | 26 | Mouse | 9.7 | pKi | None | 9.7 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 8946946 | |||
| CHEMBL33884 | 1841 | 48 | None | 1 | 26 | Mouse | 9.7 | pKi | None | 9.7 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 8946946 | |||